ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-HSA-1169091.2 Activation of NF-kappaB in B cells 5708 5709 1147 84433 5700 5701 5702 5704 5705 4790 5682 5683 4792 5684 4793 5685 4794 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5970 5695 7314 6500 3551 5687 5688 8517 5689 5966 8915 9861 8454 6233 7316 5579 10892 10213 6885 5706 23291 5707 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine 116285 348158 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors 6613 4306 2516 5914 10401 7341 7068 5241 7376 6256 7421 5465 8554 2099 7181 6095 367 4929 2908 51588 6612 9759 5468 7329 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 96%5685942 HDR through Homologous Recombination (HRR) 51750 54107 5888 80010 5889 7979 7311 7314 348654 7486 5981 5982 5983 3364 472 56655 672 675 84126 144715 83990 5810 7516 5932 7517 9156 5111 11073 80198 641 55732 79008 6117 5984 5985 5424 6119 5425 79728 6118 5426 5427 5429 5883 5884 116028 10635 10714 146956 1111 197342 83695 84464 10111 51426 57804 4361 7156 6233 5890 7316 5892 4683 580 23514 63979 10524 1763 545 PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 996 51434 51433 5347 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876384 Listeria monocytogenes entry into host cells 1500 1499 7314 30011 999 6457 867 10254 6714 6233 7316 9146 6456 4233 8027 6455 2060 7311 79872 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 96%187687 Signalling to ERKs 53358 7867 5900 7529 5603 5604 5605 6014 4893 6654 6016 3265 9261 2889 673 1399 1432 1398 5898 5899 4803 25759 5594 5595 6300 6464 10818 4914 5906 57498 5600 DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle 162417 445 435 1373 10166 5009 57407 383 HEME SIGNALING%REACTOME DATABASE ID RELEASE 96%9707616 Heme signaling 96764 113235 2033 3043 23643 3162 3040 571 6907 80205 335 51266 8648 338 10891 4862 7514 7975 10499 10498 79718 6604 4208 4209 7099 9575 4780 8204 64784 8841 9611 23411 9572 200186 6256 1387 23373 5465 23054 1386 5469 85441 6095 406 10743 10424 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 96%1168372 Downstream signaling events of B Cell Receptor (BCR) 5708 808 5709 5478 1147 5530 84433 5532 5700 10125 5701 5702 5704 5705 4790 5682 5683 4792 5684 4793 5685 4794 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5970 5695 7314 6500 3551 5687 5688 8517 5689 4893 5966 8915 3265 9861 8454 6233 7316 5579 4772 10892 4773 10213 25780 6885 5534 5706 2280 23291 5707 4775 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME%R-HSA-8862803.4 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 84290 5052 7001 4001 7531 8851 1020 351 2801 10018 993 994 356 995 831 823 824 826 6648 2309 3725 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport 23446 126969 204962 345274 80736 57153 60482 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 96%2644605 FBXW7 Mutants and NOTCH1 in Cancer 4851 9978 6500 8454 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373080 Class B 2 (Secretin family receptors) 7484 7483 30817 5741 2793 2792 2791 2790 7480 9340 7482 7481 2788 2787 796 2786 80326 797 2785 116 2784 2740 117 799 2783 6469 51764 94235 3375 1394 1393 54361 1392 55970 113091 79924 10266 5744 5745 10268 5746 10267 50846 90226 2692 2691 6608 133 54331 51384 114131 59345 2642 2641 7855 7976 976 8321 7473 8322 7472 89780 7475 7474 8325 7433 6344 7477 8326 7476 7432 6343 8323 7479 8324 7434 7478 8643 2782 7471 3549 84658 2778 2535 2015 2696 2695 7349 10681 11211 1604 5727 10203 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs 8452 5708 9462 5709 4763 64926 84078 5700 5701 8831 5702 399473 5704 10156 5705 161742 200734 5682 22821 5683 153090 8437 5684 5921 5922 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 9978 7314 5687 5688 5689 4893 3265 9861 6233 7316 10213 5706 5707 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%888568 GABA synthesis 2571 2572 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation 633 1464 1463 89944 10675 1462 2990 23553 3373 8372 112937 3074 3073 63827 1634 3425 79411 2720 411 3423 DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51434 51433 7027 1021 1019 595 1017 894 896 1871 898 1870 51343 6502 1616 9134 1028 1027 1026 546 7029 1869 5925 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702596 lestaurtinib-resistant FLT3 mutants 2322 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2500257 Resolution of Sister Chromatid Cohesion 891 983 5347 54908 6232 8655 25909 8379 9183 23047 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 113130 348995 348235 9126 5048 23421 57122 220134 57082 57405 147841 51143 6249 55746 7514 4085 9133 64105 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 1781 23122 23244 1780 79172 1778 81930 10735 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 5903 2491 5519 332 55143 23063 699 11243 10274 140735 3619 5515 11004 5516 5518 9212 25936 8243 11130 64946 79980 10726 79902 5885 5525 5526 55839 5527 5528 5529 55732 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME%R-HSA-9927426.2 Developmental Lineage of Mammary Gland Alveolar Cells 5617 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 96%5423599 Diseases of Mismatch Repair (MMR) 5395 4436 4437 4292 2956 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 96%388479 Vasopressin-like receptors 5020 551 5021 552 553 554 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 96%1483101 Synthesis of PS 9791 81490 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 96%351906 Apoptotic cleavage of cell adhesion proteins 9414 1499 1829 1828 999 7082 836 5317 1832 1830 100506658 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 5440 5441 8732 4331 8731 1022 2071 6829 2966 2965 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 96%2395516 Electron transport from NADPH to Ferredoxin 112812 2232 2230 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9608290 Defective MUTYH substrate processing COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 96%388841 Costimulation by the CD28 family 8331 7004 8337 7003 8334 7005 8335 2353 5062 10613 117145 100128731 192670 27161 8341 8463 8342 8347 8348 8345 91445 6048 26523 8340 10987 53632 2354 2475 91319 8338 4791 10956 85236 1499 8349 5879 6185 23112 23476 6184 57690 2932 192669 746 79109 1603 5781 2034 3123 3122 27248 3120 8370 3119 3118 146850 79139 151888 3115 2146 3113 998 5777 51009 4343 6400 3013 3127 3126 3125 55615 255626 23308 84061 5562 5563 6772 5564 6774 5565 3021 3018 2033 3017 3014 80380 3932 5571 7991 64223 474382 201595 10000 3703 8970 128312 27327 9020 3716 83439 55766 1650 8726 8968 10331 7532 23533 4780 3727 51176 7525 207 208 7409 653604 7415 1387 84661 8503 11091 25937 5133 8764 23512 1326 5928 5929 2534 1445 467 3725 9978 8452 1019 595 9861 8454 6233 7316 10213 5706 5707 5708 5709 5519 5700 5701 5702 5704 5705 4790 5682 5683 5515 5684 5516 5518 5685 5686 5717 5718 5719 8945 11047 5713 5714 5525 7979 5526 5690 5691 5527 5692 5528 5693 5529 5694 7311 5970 5695 7314 6500 5687 5688 5689 4297 1460 1459 1457 4609 5931 8405 915 10413 916 917 3091 4067 94239 9070 920 4613 11160 4751 9402 253260 57761 29126 142678 51422 3659 5294 5295 5296 5058 1493 5290 5170 5291 5293 54145 58505 940 941 942 6932 6934 58508 5063 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome 6872 22916 6874 6873 6908 4686 6827 6749 6881 6880 6883 6882 6884 8148 9150 6917 1025 51497 11198 6875 6878 83860 6877 8812 2959 2958 6879 2957 25920 54457 2961 2960 51224 6921 6924 7936 6923 7469 138474 904 905 5440 5441 8732 4331 8731 1022 2071 6829 2966 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 8178 129685 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%190872 Transport of connexons to the plasma membrane 2697 2706 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding 2793 2792 2791 2790 908 113457 6950 898 7203 7280 2788 26272 2787 6905 2786 83752 9134 26234 10693 2785 6468 10574 2784 10376 10694 6902 10576 2783 2629 10575 51764 80086 26190 94235 6904 26270 6903 9630 51807 6000 55970 22803 8787 7411 10381 10383 8786 10382 55294 112714 6774 55135 402 9628 7846 60 84790 54331 10471 1460 5201 1459 5202 59345 1457 6499 5082 84617 11328 10238 2767 26330 10517 1155 347733 84261 2769 7277 7157 22948 7278 63971 26985 26224 81027 79861 8841 54461 2776 10528 5203 5204 2782 8877 10564 10681 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 10762 8815 348995 79902 57122 55746 23279 79023 6396 9883 129401 9688 291 292 293 23225 3836 4927 3159 23165 11168 55706 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 96%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components 4085 9184 51529 7321 991 8881 64682 25906 701 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51434 51433 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) 1616 546 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 96%113507 E2F-enabled inhibition of pre-replication complex formation 23595 4998 891 4999 983 84515 5000 5001 23594 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 96%112303 Electric Transmission Across Gap Junctions 57369 56666 10052 84694 24145 INFLUENZA INFECTION%REACTOME DATABASE ID RELEASE 96%168255 Influenza Infection 23636 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 6230 6231 6234 9349 6235 6191 7040 6193 6192 6194 10898 1213 51121 1211 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 197259 3921 4736 6130 6133 6132 6135 6134 6137 6136 811 6232 6128 9636 6129 6142 6141 6144 6143 6146 6147 142 3304 821 6139 6138 6152 6155 6154 6157 6156 6159 6158 3320 2197 348995 23521 3837 140032 3838 3839 57122 5610 5611 6164 6166 6165 6168 6201 55746 7514 6167 8106 6203 6169 6202 23279 116832 79023 6160 6161 2633 402569 3840 3841 6396 3843 5901 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 2926 6209 6208 6188 6187 6223 6189 6222 5903 6224 6181 6218 6217 79902 7311 5440 5441 2963 2962 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 9883 129401 9688 293 23225 3836 4927 23165 55706 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 96%5633231 Defective ALG14 causes ALG14-CMS 199857 79868 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME%R-HSA-8939245.2 RUNX1 regulates transcription of genes involved in BCR signaling 1998 1997 640 861 5079 865 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism 60490 8034 8875 8876 5167 5168 8884 5169 2194 80025 284439 254552 80347 53354 79877 79646 60496 55229 79717 51248 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides 51296 6564 1497 121260 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript 23636 22916 5903 9972 9631 7175 11097 4686 23511 8086 8021 53371 8480 10762 79902 9785 6430 6432 6431 9984 10250 29107 22794 57187 51362 7919 199746 84324 84248 6427 6426 84321 6429 9939 6428 10212 728343 9877 51213 10189 84271 65109 80145 26097 8563 8683 10482 9775 9295 10921 10569 11338 2733 55110 79228 4116 7307 348995 57122 55746 23279 79023 6396 9883 129401 9688 23225 4927 23165 55706 FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9832991 Formation of the posterior neural plate 89780 5453 5015 6656 2253 6911 6657 2637 9839 25925 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis 26523 23405 8575 192669 7257 6895 7247 192670 27161 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels 7220 7442 7222 7224 7223 7226 7225 59341 79054 55283 26133 54795 8989 55503 4308 162514 255231 57192 51393 80036 56302 57113 29850 54822 140803 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells 3910 3911 3912 3913 3914 3915 2335 3918 284217 10319 3908 3909 7448 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME%R-HSA-164940.5 Nef mediated downregulation of MHC class I complex cell surface expression 8907 130340 3105 567 10053 1174 8905 162 55690 164 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 9424 3775 10089 PROTEASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9907900 Proteasome assembly 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 143471 389362 5686 5698 5717 5699 5718 56984 5719 51371 80227 11047 5710 5713 10197 5714 122706 7979 5711 5690 8624 5691 5715 5692 5716 5693 84262 5694 5696 9491 5695 23198 5720 5721 5687 5688 5689 9861 10213 5706 5707 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation 5708 5709 1147 84433 5700 10125 5701 7321 5702 5704 5705 4790 5682 5683 4792 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5970 5695 7314 6500 7322 3551 997 5687 10454 5688 7334 8517 7335 5689 5588 7189 8915 10235 257397 115727 23118 4067 5170 9861 8454 6233 7316 10892 10213 6885 5706 23291 5707 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9856649.3 Transcriptional and post-translational regulation of MITF-M expression and activity 7531 1499 999 2932 7341 22797 6591 6195 51520 1615 5859 4140 4141 5594 5077 5595 7534 1908 7533 3376 3094 7965 1906 7329 9521 7545 5443 4157 7529 3065 1910 3815 27022 1435 5917 257 6926 3735 4161 9255 8600 4286 6663 2033 6662 5454 3397 7030 4160 6657 2058 4159 7942 10000 7514 89780 7532 51176 23411 1387 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209968 Thyroxine biosynthesis 1734 1733 389434 857 90527 6528 1735 7252 50506 53905 405753 51061 1081 7173 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 96%9748787 Azathioprine ADME 5879 64078 7498 7410 55270 3177 9153 3251 7172 7409 2030 3615 2944 3614 2987 10451 4830 2939 4831 8833 10057 2938 10257 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle 8452 23221 29766 6093 3183 55023 11329 56254 5930 71 9318 5756 4646 7431 9475 124540 23013 27316 3320 9352 3326 2873 79869 51138 1627 87 10250 908 7919 10574 10576 11140 6434 9886 8654 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA 84296 4171 51659 4172 4173 4174 4175 84515 4176 64785 8318 9837 NGF PROCESSING%REACTOME DATABASE ID RELEASE 96%167060 NGF processing 5045 5046 5125 4803 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer 7046 7048 7040 MTOR SIGNALLING%REACTOME%R-HSA-165159.9 MTOR signalling 192670 27161 26523 53632 2475 6194 23112 57690 51719 6794 192669 7248 29904 1975 55004 8649 1978 1977 5230 64121 92335 1981 7249 58528 10542 389541 28956 57521 10670 6009 5494 153129 4343 81617 84335 55437 10325 7529 5562 5563 5564 5565 5571 64223 10000 27327 207 51422 208 2280 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 96%5579007 Defective ACY1 causes encephalopathy 95 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 96%168799 Clostridium neurotoxicity 22987 112755 127833 9899 6843 9900 6844 6616 6857 6804 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME%R-HSA-5467333.3 APC truncation mutants are not K63 polyubiquitinated 324 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters 6569 142680 10568 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME DATABASE ID RELEASE 96%5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) 1147 3551 8517 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 96%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 2194 6256 5465 96764 3638 51360 3837 2224 2222 3157 6907 6667 80205 51128 4800 4801 8648 4802 6309 10654 9871 9632 57678 10499 10427 10498 6713 6319 79718 22937 6604 4597 79071 51141 1595 6721 1717 31 5901 32 9453 4047 4520 8720 1387 10802 3422 23054 4598 10484 5469 7108 85441 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 96%451308 Activation of Ca-permeable Kainate Receptor 808 2900 2899 2898 1742 2897 83988 1741 1739 2901 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME DATABASE ID RELEASE 96%8875360 InlB-mediated entry of Listeria monocytogenes into host cell 7314 30011 6457 867 10254 6233 7316 9146 6456 4233 8027 6455 2060 7311 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E 7314 6233 7316 7311 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5218859 Regulated Necrosis 92421 3002 355 27243 3553 128866 834 10211 10015 837 838 7332 8743 5071 83737 79643 841 356 51652 8737 329 11035 54205 2319 3606 8795 7186 8473 3660 10273 8797 57162 79792 7311 330 331 578 7314 1991 29082 8626 6386 91782 3552 25978 581 1687 3146 8717 197259 836 3320 7157 3659 6233 7316 11140 8772 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 96%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) 6584 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%8866376 Reelin signalling pathway 7436 5649 30011 2534 1600 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 96%8949613 Cristae formation 539 518 10476 10632 4580 9551 9556 25813 84833 10989 125988 521 522 139322 55735 8834 506 54927 509 440574 27109 79135 4508 4509 498 3313 84303 513 514 515 10651 516 517 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-HSA-110314.5 Recognition of DNA damage by PCNA-containing replication complex 54107 5981 5982 5983 56655 8451 7320 8450 56852 7398 5111 1642 57599 51514 6117 5984 7311 5985 5424 6119 9978 7314 5425 6118 5426 5427 10714 57804 6233 7316 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%5578775 Ion homeostasis 808 817 818 6263 6262 6588 6786 6543 6261 10768 3708 3709 1760 5566 476 477 478 7220 6546 53822 4842 6547 3710 53826 5350 10060 53828 7137 80228 480 1193 481 2281 482 483 486 487 488 444 489 84876 5348 5349 10345 3767 6717 490 491 492 493 815 816 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 51343 119504 6502 29882 246184 996 51434 51433 5925 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559583 Cellular Senescence 8331 8337 8334 51529 7321 8335 2353 8881 64682 25906 11065 8697 7324 192670 10393 29945 8341 27338 119504 8342 29882 8347 8348 246184 8345 996 51434 26523 51433 8340 8338 85236 8349 23112 7027 1021 1019 57690 3552 1017 192669 1871 898 9261 1870 51343 6195 1432 9134 8370 1027 1026 5594 7029 1869 5595 5925 2146 4343 5600 3013 7867 255626 6774 3021 3018 3017 3014 3397 474382 8970 128312 27327 55766 8726 8968 653604 6233 23512 7316 5928 4001 4790 6197 6196 8535 8091 23043 26277 79813 25913 7290 7295 3490 57634 3009 3725 3008 3007 3006 3005 648 4217 7311 4194 5970 8550 6015 7314 3024 25842 890 4193 1912 1911 10919 5608 54386 5609 80012 84733 6416 5601 5602 5606 2077 8290 23523 27287 6045 7013 65057 7014 5598 1032 1031 23135 1030 1029 3569 2114 2113 50488 9448 23466 3456 3576 5599 8900 472 29855 1051 57332 6667 5931 94239 7157 10111 4361 54145 4683 3159 10524 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 7027 1021 1019 595 1017 894 896 1871 898 1870 9134 1028 1027 1026 7029 1869 5925 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 96%9006115 Signaling by NTRK2 (TRKB) 5879 6714 4893 8851 6654 1020 3265 5781 7074 5295 4915 1795 4908 10817 5290 4909 5335 627 2904 2549 10818 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes 7975 1387 4851 2033 6667 374 596 4780 5154 1950 598 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation 6222 6224 6181 6218 6217 6230 6231 6234 9349 6235 6191 6193 7311 6192 6194 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 1938 6168 1937 6201 1936 6167 1933 6203 1917 6169 1915 6202 116832 6160 6161 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) 7249 7248 10000 207 208 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2691230.3 Signaling by NOTCH1 HD Domain Mutants in Cancer 4851 7314 9148 28514 182 54492 57534 102 54567 6868 142678 3714 6233 7316 7311 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%389357 CD28 dependent PI3K Akt signaling 55615 117145 3932 64223 10000 2475 9020 253260 23533 57761 79109 207 208 5294 5295 5296 8503 5290 5170 5291 146850 5293 1326 940 941 2534 942 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 96%191859 snRNP Assembly 23636 22916 5903 9972 9631 7175 11097 4686 23511 8086 8021 53371 8480 10762 79902 96764 348995 57122 55746 23279 79023 6396 50628 6632 10419 6628 51808 79084 79760 54960 9883 129401 6634 6633 9688 6636 6635 6637 25929 23225 10073 4927 79833 6607 23165 8487 11218 55706 1207 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives 5743 240 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels 3764 6833 10060 3767 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 96%174577 Activation of C3 and C5 721 727 629 717 718 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion 11181 6476 8513 8972 8544 2980 280 119548 27159 1118 3938 278 2984 279 248 1056 2981 5406 5407 1208 5408 RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP 8894 8891 8892 1968 8890 1967 8893 1965 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69580.5 p53-Dependent G1 S DNA damage checkpoint 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 4194 5695 7314 890 5687 25946 4193 5688 57060 64326 5689 1017 11200 51230 898 9134 1027 1026 1029 8900 472 7157 9861 6233 7316 10213 5706 5707 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 96%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) 23443 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity 6502 7975 7314 9978 6500 8454 571 6233 7316 64839 7311 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids 8501 153201 6520 6541 123096 81539 8140 23657 55117 56301 11254 6512 6539 11136 6519 124935 54407 23428 92745 6511 6533 6510 206358 84889 120103 6509 55089 117247 340024 10991 6506 6505 54716 6507 9056 9057 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein 821 84061 100128731 11282 7841 29801 25921 253832 51201 7991 55741 11320 51125 201595 4247 51304 3703 4249 10610 6483 6482 6484 6487 4245 1650 6185 4124 6480 25834 6184 23193 256435 79844 2530 27090 746 11253 5589 1603 51114 58505 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 96%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 808 817 818 88 22843 1740 2906 9647 8536 2905 814 2904 2903 4747 2902 1742 1741 1739 815 816 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response 3569 1432 5045 79651 10769 6868 9332 3586 4627 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 96%168316 Assembly of Viral Components at the Budding Site 821 811 ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%9645460 ALPK1 signaling pathway 7314 10454 6233 7316 7189 6885 257397 80216 23118 7311 92610 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex 4085 9184 51529 7321 991 8881 64682 25906 701 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51434 51433 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway 8331 7004 8337 7003 8334 7005 8335 2353 192670 27161 8341 8463 8342 8347 8348 8345 26523 8340 53632 2475 8338 85236 8349 23112 57690 2932 192669 79109 5781 8370 2146 4343 3013 55615 255626 5562 5563 6772 5564 5565 3021 3018 3017 3014 5571 64223 474382 10000 8970 128312 27327 83439 55766 8726 8968 7532 51176 7525 207 208 653604 84661 11091 25937 23512 5928 5929 8178 129685 6872 6874 6873 6908 6827 6749 6881 6880 6883 6882 6884 8148 9150 6917 1025 51497 11198 6875 6878 83860 6877 8812 6879 25920 54457 51224 6921 6924 7936 6923 7469 138474 904 905 7157 7040 142 1998 1997 640 861 5079 865 25925 6657 7222 5588 7534 7533 5443 3065 3815 6662 1081 857 5045 6794 7248 55004 8649 64121 7249 58528 10542 389541 28956 57521 10670 6009 5494 153129 10325 6667 4800 4801 4802 57678 355 834 83737 54205 8795 10273 8797 8626 581 815 816 817 818 5566 8535 79813 7295 648 4194 8550 6015 890 4193 1912 1911 10919 5608 80012 84733 27287 6045 1030 1029 3569 23466 8900 1051 57332 627 2904 28514 182 10419 25946 57060 11200 51230 814 2903 10769 25904 168374 5816 29028 284459 3630 90317 155061 10650 2308 121274 55571 54487 284443 6910 155054 90589 147694 1482 80778 339488 6929 246175 147686 147687 90338 3654 100129842 4986 4988 64065 22869 90576 90333 6940 2100 285349 353355 81856 81857 1490 6938 100131980 79788 283337 4512 4513 4514 22835 3683 1263 2593 114787 80317 146540 84914 84924 57547 2104 57541 2103 2101 55367 3674 835 3676 3678 284252 839 90594 6720 90592 84911 146542 10628 80314 1024 843 604 847 4778 440077 84701 3458 1278 1277 6722 5875 4303 5876 4322 56242 57573 147657 57336 440073 10848 864 57335 50943 6750 3486 3484 23327 199704 632 389114 51123 7832 10013 637 84289 639 10014 11105 162655 146198 117608 405 4336 6515 10025 23309 7862 7621 2177 2176 892 650 51385 171392 7633 7874 148156 3276 23314 665 341947 79943 7626 10001 7625 11335 7627 3280 6790 126375 25942 374900 55762 79973 79733 5457 5458 7638 348327 7652 23774 29079 57711 5467 55778 10224 8738 91875 7422 163732 221785 374928 3066 200845 148103 3064 694 79755 55786 79759 140612 4149 158399 10432 7673 9612 169270 463 79744 9862 6595 6597 619279 6599 6598 30818 728957 94241 84449 117584 84441 7678 117581 8784 7692 7695 7694 5275 7697 7699 163227 163223 79088 84676 28984 84436 84671 8794 54807 8793 8312 163255 23269 59269 54811 55900 54815 5054 9656 9891 8317 11059 80095 9422 10172 9668 201514 84246 51564 94039 23019 115196 50484 23493 51333 9443 7022 7021 9861 9441 9442 8454 126070 6233 7025 7316 26974 5579 65988 10213 25888 9440 23468 5706 7020 728927 5707 23460 5708 51586 5709 23462 10398 9439 5700 10397 5701 10155 5702 286075 5704 1956 5705 4790 7039 5682 126068 5683 374879 127396 5684 2811 2810 5685 51592 55713 5686 10168 9464 5717 114907 5718 84838 5719 2821 11047 26152 26155 5713 163081 5714 9219 7979 5690 374655 5691 9477 5692 7296 5693 7057 5694 112950 57472 7311 7291 5970 5695 57474 91120 7314 6500 7050 169841 5687 83744 5688 163071 83746 5689 83741 390927 147837 1749 8396 7067 7341 7068 1514 5241 204851 1513 7376 84626 6256 7421 80264 5465 1750 29883 3930 2099 1515 7181 26149 6095 63934 367 57492 4929 163087 2908 79027 144348 9021 9759 5468 2625 3958 7329 2624 60436 2623 2516 84883 5914 2626 90075 7486 3726 79047 2877 5982 84874 5983 2874 3364 472 84870 80032 672 113835 93134 199692 84126 144715 163059 83990 23067 5810 9282 2891 28996 5932 92285 92283 9156 256051 5111 11073 5915 5916 641 2645 146713 143686 6117 51741 341359 5984 3977 5985 2648 6119 63970 349075 2660 6118 163049 1327 163051 4839 5883 163050 5884 654254 116028 900 901 51755 340252 1329 1111 30832 65243 83695 285676 4850 10111 1340 79891 4361 3516 4848 7156 2669 5892 1337 4849 4683 79898 580 5933 4602 5934 10524 1763 1339 4605 545 23619 1351 5888 65018 80010 1350 100287226 51529 1349 1107 7321 79885 8881 64682 1347 25906 1346 11065 388536 1345 8697 55215 7324 10393 10308 124411 29945 10781 27338 119504 10780 29882 4852 891 4853 246184 4854 10782 983 4855 996 65251 51434 1108 51433 162966 162967 162963 1121 4233 100289635 22974 388569 83933 388566 1499 388567 4869 388561 9099 5728 284309 6714 125965 284307 284306 400720 58500 10520 4878 10765 3562 55240 3559 1432 27165 3558 1378 147741 27166 253639 5594 7913 5595 10971 5978 5979 284370 115509 90233 5600 29117 57677 3329 22938 79230 7529 339327 339559 146434 26053 124446 353274 6601 6603 6602 6605 158431 57209 5770 91584 2033 7710 57693 387032 613227 27153 6907 27154 57459 133383 7700 7703 4435 10891 219749 10370 5300 7514 220992 51003 10498 5775 79718 7712 6604 442319 7711 4208 79818 10135 10138 266743 4221 148254 4697 8841 9611 51499 5305 23411 5308 9572 90827 1387 7728 2290 23429 1386 7743 5469 148266 148268 406 80818 2289 342926 23660 4773 56950 55869 6886 7733 54778 808 7738 9915 23439 730087 7752 7994 5052 7753 7001 2064 2063 441234 7531 54541 8851 1020 55634 51276 353088 10018 7745 56729 5325 7988 356 995 7748 136051 10127 8850 7761 6648 7760 2309 91975 3725 7762 114026 3164 339500 4004 4488 100129543 7755 4851 4005 317 9978 7757 55888 7770 8861 219578 7771 7773 8621 90874 162972 23410 161882 148213 3174 3172 148203 51058 196528 148206 7767 5105 55659 7766 7769 55657 7768 7528 6696 5366 730291 126231 55663 1392 579 55422 6446 6688 10794 10793 10795 7539 5371 7552 7551 9975 285267 9734 285268 4287 7556 255403 79862 348 9968 9969 7549 57615 90649 100131827 7561 7562 7565 7323 122809 7567 7566 7559 9739 8409 6241 94115 7571 7574 9997 7576 29959 51412 7568 80196 54925 8431 3549 7582 7101 25 7587 6498 7586 6497 6258 6257 7581 84108 9757 8427 7594 4086 7596 4087 4088 4089 9534 8445 7592 126382 84333 199777 53615 9540 7122 2572 64750 2571 4091 23368 4092 4094 85456 197320 84124 54715 5196 9794 9310 6046 9314 64769 25799 1820 440519 440515 54971 9337 162239 7027 7159 1021 181 1019 90809 595 54989 1017 152687 894 55835 896 10046 8239 898 86 8013 51343 79370 6502 8493 7161 1616 170960 9134 57343 1027 57103 1026 125919 147948 7029 147949 9358 1869 5925 170959 26048 55170 90390 80108 80110 221044 9125 6097 342132 285971 7182 6096 144455 1876 4904 1875 1874 26013 282890 344787 9377 8289 92595 55193 1643 27113 80139 168417 1649 2737 1647 2736 79175 133746 93474 2744 84527 387893 84765 58484 57154 83667 3845 133522 9167 121340 58491 58492 1437 1436 147923 27300 59348 147929 340385 8089 112858 8085 84775 3622 2539 2538 5519 332 5515 5516 5518 9212 5527 5395 4436 4292 100506658 7082 5440 5441 4331 1022 2071 6829 2966 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 4297 1460 1459 1457 4609 5931 10413 94239 9070 253260 51422 1493 5170 54145 6932 6934 58508 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF 808 10256 817 54518 818 8826 22866 7529 7450 3690 5604 5894 5605 5037 2243 7094 5908 369 283455 408 409 3845 6714 4893 3265 673 4140 5594 4296 5595 8315 2335 5245 3717 2244 1445 2266 5906 7414 815 3674 8844 816 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins 4048 240 3248 XENOBIOTICS%REACTOME DATABASE ID RELEASE 96%211981 Xenobiotics 1562 1573 9915 1551 54905 1549 1548 1559 1572 1571 64816 57491 196 1558 405 1557 1577 1555 1544 1565 1543 1576 1553 29785 IRON UPTAKE AND TRANSPORT%REACTOME%R-HSA-917937.6 Iron uptake and transport 7311 7314 6500 48 4891 245972 245973 30061 3163 10539 155066 9114 55240 51606 9550 94033 26234 4738 2512 79689 523 9429 525 526 527 528 529 8992 9843 90423 2495 127124 23545 51382 1356 533 534 535 7018 537 10312 3658 3934 50617 7037 7036 113235 3077 9296 55832 51310 3162 79901 57192 8454 6233 7316 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 96%69017 CDK-mediated phosphorylation and removal of Cdc6 5708 5709 5700 51529 5701 7321 5702 5704 8881 64682 5705 25906 11065 5682 8697 5683 7324 5684 10393 29945 27338 5685 119504 5686 29882 5717 5718 246184 5719 996 11047 51434 5713 51433 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 890 5687 5688 5689 1017 898 51343 9134 8900 990 9861 6233 7316 10213 5706 5707 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-HSA-1606341.4 IRF3 mediated activation of type 1 IFN 29110 147945 3661 23220 81030 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers 6549 10479 285195 23315 84679 6550 6553 389015 6548 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 96%1234158 Regulation of gene expression by Hypoxia-inducible Factor 1387 2033 25994 7422 2056 405 768 10370 2034 3091 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency 594 10295 1629 1738 593 COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-HSA-8948216.4 Collagen chain trimerization 91522 1297 1296 1295 1294 1293 1292 1291 1290 1305 1303 1302 1301 1289 1300 1288 1287 85301 1308 1307 1278 84570 1277 1306 50509 1286 1285 256076 1284 1282 1281 169044 1280 81578 80781 255631 1299 1310 57642 1298 340267 7373 131873 136227 LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism 5566 9388 26119 27329 338328 319 81693 255738 51129 10577 9619 7311 91289 10062 5034 7314 1213 4023 5045 8029 5046 1211 19 5125 160 161 1071 116519 163 2 23491 29116 57552 4018 7436 7376 8435 213 336 337 4864 6646 3931 4547 26291 55908 3990 64788 1175 1173 341 3949 344 345 346 3069 84699 51599 5567 55911 5568 3988 51360 29801 348 51128 335 338 8720 6233 7316 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953080 MPS VII - Sly syndrome (CS DS degradation) 2990 NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration 48 3417 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 96%71387 Carbohydrate metabolism 5567 5568 5261 10090 8534 23729 64711 9061 9060 222537 337876 230 5260 2548 231 4969 27087 51084 29940 2542 10894 83592 6483 6120 6482 6484 2683 6487 3099 3098 54480 4060 55454 2799 10331 55576 30815 56548 22856 11041 729020 28 11285 2331 378884 2203 6007 60495 6006 8789 11046 5834 5836 5837 10057 9653 6383 10082 6385 2584 2582 808 130589 54020 6382 124872 10402 11261 2592 8692 7360 80201 10855 2588 3795 221914 9672 5631 9435 25796 166012 2239 960 284129 2597 64080 10861 5507 221823 22934 132158 3101 2132 2131 3340 387712 176 3339 178 8908 5634 1836 4669 347734 9334 9331 2023 2262 5091 26503 79586 55276 5230 2137 3906 2135 57214 2817 7167 5105 9469 9348 23563 90161 23324 2027 51363 2026 51000 26035 7957 92579 79369 6513 2719 5549 6652 92126 64579 126792 80146 55501 8703 8704 6888 8702 9917 8707 8708 8705 266722 5210 5211 4123 5213 10007 669 57818 26330 5207 5208 5209 9942 5223 5224 10690 3161 7086 283209 3038 3037 3036 4125 5214 113189 4126 50515 5232 9953 9951 9883 92370 129401 26007 9688 132789 9394 2998 2997 23225 2632 2992 4927 6677 5226 23165 5106 375790 55706 11081 64131 23636 64132 9972 9631 93010 7175 51181 2526 11097 2646 23511 10678 8086 8021 2525 2524 53371 8480 2523 10762 10317 216 9957 5236 9955 6448 9956 1462 8509 2990 2529 23553 2528 3373 135152 8372 2527 112937 5255 4166 3074 5256 3073 63827 5257 1634 26229 3425 55790 79411 51071 2720 4958 411 10327 3423 226 633 83440 1464 229 1463 89944 10675 348995 57122 55746 23279 79023 6396 2539 6233 2538 7316 5903 5519 5515 5566 5516 5518 2821 79902 5528 7311 7314 1514 2645 6548 INACTIVATION OF CDC42 AND RAC1%REACTOME DATABASE ID RELEASE 96%428543 Inactivation of CDC42 and RAC1 9353 5879 23380 57522 6091 9901 80728 998 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling 4908 4915 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 7314 7099 929 7187 9641 353376 148022 10010 10133 23643 29110 6233 7316 7311 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 96%71384 Ethanol oxidation 125 84532 126 127 128 217 55902 219 130 131 216 124 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 96%9706377 FLT3 signaling by CBL mutants 7314 867 6233 7316 2323 2322 7311 DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9657050 Defective OGG1 Localization TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 63976 4086 7350 1149 3065 83401 23090 4089 1107 1346 53615 1108 57459 5931 9219 8648 10891 54815 133522 3066 6256 5465 5928 57504 655 3192 9112 5468 64641 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins 5970 10401 10210 8517 5610 9641 51588 4792 6612 7341 4791 7329 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage 161823 4860 270 271 272 51292 132 3251 100 353 2766 1633 1716 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 96%5679096 Defective ABCG5 causes sitosterolemia 64241 64240 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 96%9683701 Translation of Structural Proteins 821 7841 2589 54956 143 2931 56965 83666 79668 84875 54625 10610 6483 6482 7311 6484 6487 7314 4245 6480 23193 256435 2932 27090 5589 7341 6233 7316 7329 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway 808 5530 5532 3708 3709 192670 27161 26523 1499 23112 2793 57690 2792 2791 192669 2790 7481 2788 2787 2786 2785 2784 2783 51764 94235 4343 55970 54331 59345 7855 7976 5145 27327 5578 8322 5592 5593 83439 5158 3710 5148 7474 51701 5330 5331 2780 23236 2775 51176 8323 2782 2535 4772 10681 6885 6932 5534 6934 815 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 3329 29028 284252 3815 2064 79047 1956 7039 2033 339488 348 4609 4435 51741 10370 1081 4869 7422 163732 4839 94115 83741 7341 10765 5308 8089 1387 7022 7021 2099 1026 7913 7528 7020 4605 7329 DEFECTIVE MAOA CAUSES BRUNS%REACTOME DATABASE ID RELEASE 96%5579012 Defective MAOA causes BRUNS 4128 ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9700645 ALK mutants bind TKIs 27436 6801 9451 4869 1213 2335 3092 57448 5495 5573 53335 238 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70688 Proline catabolism 58510 8659 5625 DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 96%73928 Depyrimidination 8331 3013 8337 8334 8335 255626 8341 3018 8342 3017 8347 26277 3014 8348 8345 25913 8340 474382 8970 128312 8338 85236 8349 94239 55766 54386 8370 8290 8930 55247 54145 23583 7013 252969 65057 4968 7014 79661 6996 4913 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME%R-HSA-168273.5 Influenza Viral RNA Transcription and Replication 23636 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 6230 6231 6234 9349 6235 6191 6193 6192 6194 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 142 6139 6138 6152 6155 6154 6157 6156 6159 6158 3320 2197 348995 23521 140032 57122 5611 6164 6166 6165 6168 6201 55746 6167 6203 6169 6202 23279 116832 79023 6160 6161 6396 3843 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 2926 6209 6208 6188 6187 6223 6189 6222 5903 6224 6181 6218 6217 79902 7311 5440 5441 2963 2962 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 9883 129401 9688 23225 4927 23165 55706 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) 92421 55048 89853 11267 27243 51028 155382 128866 137492 27183 93343 7251 51271 79720 84313 51510 51534 79643 51652 9146 8027 7311 7314 29082 10254 91782 25978 6233 7316 9525 51160 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 96%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 23466 26053 6601 861 84333 6603 6602 865 6605 57332 8535 8289 2033 55193 28996 1460 1459 1457 648 6015 6604 1912 10138 1911 80012 86 84733 51412 23429 196528 6045 57492 6595 6597 6599 6598 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-HSA-5389840.3 Mitochondrial translation elongation 64432 65003 64951 65005 65008 28977 90480 51081 7284 6150 55168 64949 28973 65080 51642 5018 54998 10573 11222 128308 51649 9553 64960 92259 63875 64963 64965 64968 55173 55052 64969 51373 26284 51650 60488 51253 51258 219927 29074 10102 56945 64975 28998 64976 79590 64979 64978 23107 28957 64928 7818 57129 51263 29088 51021 54534 51023 51264 51069 84545 85476 78988 122704 65993 64981 10240 64983 3396 26589 63931 6182 54460 6183 118487 51073 116540 740 124995 54148 116541 55037 29093 9801 51116 10884 54948 51318 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.5 G1 S DNA Damage Checkpoints 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 993 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 4194 5695 9978 7314 6500 890 5687 25946 4193 5688 57060 64326 2932 5689 1017 11200 51230 898 1432 1263 9134 1027 1026 5600 1029 8900 472 7157 1454 1452 79858 1111 9861 8454 6233 7316 10213 5706 23291 5707 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 7314 57154 7046 7048 50848 5590 387 23370 57530 56288 50855 6233 7316 7040 2280 7311 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function 611 VIRAL MESSENGER RNA SYNTHESIS%REACTOME%R-HSA-168325.6 Viral Messenger RNA Synthesis 2963 23636 2962 9972 5903 9631 5434 7175 5435 11097 5436 23511 5437 8086 5438 8021 5439 53371 8480 10762 5430 5431 5432 5433 348995 79902 57122 55746 23279 79023 6396 9883 129401 9688 5440 5441 23225 4927 23165 55706 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 96%5621575 CD209 (DC-SIGN) signaling 5970 4067 5894 5567 5062 5568 4790 4893 3265 5566 5971 5058 2033 3385 1387 3384 9252 30835 2534 5063 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E 56623 5147 200894 RHOG GTPASE CYCLE%REACTOME%R-HSA-9013408.2 RHOG GTPase cycle 9341 394 57580 396 26030 397 398 80005 5062 7879 5337 4722 10298 10652 3954 3998 9710 81839 10788 26084 26286 4698 3688 8997 6453 7984 2010 23344 143098 63916 3336 23141 23263 1794 1793 4983 3895 8987 55789 4162 7112 80728 9217 4168 9732 27237 23191 55004 81624 23592 11135 6811 1829 1969 55914 3930 998 7037 1795 857 7410 7409 5295 10451 6472 4296 7444 10424 7204 9743 2909 391 57584 392 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism 150379 2167 346606 8228 11343 646486 3991 5567 5499 64900 5568 646480 2713 2712 2710 5566 51099 150763 23175 5500 5346 10226 57678 857 9663 8694 392636 2173 2172 2171 2170 80168 84649 2820 116255 2169 5501 2168 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors 8089 1387 2033 7022 7021 339488 163732 83741 4435 51741 10370 7020 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 96%446205 Synthesis of GDP-mannose 3098 5372 5373 4351 29926 29925 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 3678 1147 5519 84290 3690 4790 6772 4792 5515 5518 5770 824 3688 826 5520 9780 302 3685 2767 10413 5747 5970 3551 8517 9641 2776 25 7414 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5688399.4 Defective ABCA3 causes SMDP3 21 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 7314 867 1956 4893 6654 3265 5295 3320 5290 5335 6233 2549 7316 6464 1950 11140 7311 SIGNALING BY ROBO RECEPTORS%REACTOME DATABASE ID RELEASE 96%376176 Signaling by ROBO receptors 5062 10298 1287 5879 6714 6654 998 5567 5568 23053 27 23708 8440 3670 6387 23032 4753 8453 4650 9423 2107 51466 4440 26986 1605 2935 56924 4690 9355 8022 7852 6092 26019 55740 1630 8829 56956 5576 9495 6655 10486 10487 57144 23767 22916 5216 5217 5532 7408 89884 4686 65110 6586 6585 3199 6921 9978 6923 8861 1981 2817 25 6230 6231 6234 9349 6235 6191 6193 6192 6194 9353 23380 57522 51121 6091 6227 9901 6229 80728 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 23332 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 5578 6201 6167 6203 6169 6202 116832 6160 6161 6175 23122 9045 6210 6176 6171 6170 6173 51065 9861 6205 6204 6233 6207 7316 6206 6209 10213 6208 6188 5706 6187 6223 5707 6189 5708 6222 5709 6224 6181 6218 5700 6217 5701 5702 5704 5705 5682 5683 5566 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 5689 22794 9939 65109 9775 10921 55110 4116 387 5058 5063 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis 10402 140838 29906 207063 6675 81849 51046 5973 51005 22845 55808 6489 64841 5476 10020 256281 79644 10825 55577 2673 8813 9945 2720 197258 8818 7264 338596 8790 55343 29880 10559 84620 2762 8869 5238 116150 55907 8128 57171 282969 26503 54187 80896 54344 79947 7903 4758 129807 4759 5372 5373 4351 29926 29925 10610 6483 6482 6484 6487 3098 6480 4597 256435 30815 27090 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry 6382 5045 3339 2719 221914 2262 9672 1514 7415 2239 2817 7113 59272 8829 26762 6383 10082 6385 375790 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 2353 595 1956 7039 207 208 1027 6722 5594 5595 374 2309 596 685 10000 1950 127933 255324 5747 2069 2002 7514 1839 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-HSA-209560.3 NF-kB is activated and signals survival 5970 4804 8878 7314 3551 4790 7189 4792 4803 6233 7316 3654 7311 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209905 Catecholamine biosynthesis 5409 7054 1644 1621 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022870 CS-GAG biosynthesis 633 1464 1463 54480 10675 55454 56548 22856 10090 55501 50515 79586 1462 166012 337876 9469 63827 1634 55790 51363 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%432720 Lysosome Vesicle Biogenesis 8907 27243 130340 8673 4074 10053 2647 1174 1777 8905 375 6844 162 1212 351 3312 164 10717 408 6845 8906 9179 23431 134829 157807 81567 1522 1785 11154 9829 9146 6456 1213 1211 2799 METHYLATION%REACTOME DATABASE ID RELEASE 96%156581 Methylation 29104 27430 57412 51504 4548 7172 4143 4144 1544 4552 9446 191 4837 1312 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176034.4 Interactions of Tat with host cellular proteins 1025 904 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 96%3656248 Defective HEXB causes GM2-gangliosidosis 2 3074 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME%R-HSA-392023.4 Adrenaline signalling through Alpha-2 adrenergic receptor 150 151 152 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112399 IRS-mediated signalling 117145 2549 5140 9965 4893 57761 6654 5289 2254 3265 2252 5781 2251 208 27006 8074 5295 2249 5296 2248 2247 2246 5290 152831 5170 8823 5291 8660 30849 2264 2255 2323 2322 54106 10818 9846 3667 8817 26281 DEFECTIVE ABCC2 CAUSES DJS%REACTOME%R-HSA-5679001.5 Defective ABCC2 causes DJS 1244 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions 3691 3910 3672 3911 3673 3912 22795 3339 3675 3655 4811 3679 3688 3913 80781 3914 3915 3918 284217 3685 10319 3908 3909 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-HSA-9616222.3 Transcriptional regulation of granulopoiesis 8331 8337 8334 8335 2672 3570 2313 861 688 1053 865 1050 8341 1441 8342 8347 8348 8345 8340 8338 85236 8349 7027 1019 1017 6256 8370 1026 7029 7913 1869 2624 3013 5914 255626 6688 1051 6774 3021 3018 2033 3017 3014 4297 4609 474382 8970 128312 94239 55766 8968 51176 653604 54145 4602 6886 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation 51529 7321 8881 64682 11065 8697 7324 10393 29945 27338 29882 246184 996 51434 51433 7322 997 7334 7335 29116 8453 54778 5930 6921 9978 6923 26272 26234 6468 26190 26270 55294 10517 7323 84261 23327 26224 54461 80196 8452 84078 7332 5071 83737 8651 64750 154881 23608 6478 7325 6477 131405 283807 221687 79654 51088 9616 90678 7318 10273 7317 56658 7319 10533 3093 22888 9870 7336 150726 10425 64718 118424 57630 23295 200845 55336 7327 7326 197131 9867 51343 7328 6502 4734 10422 54926 9520 65264 10193 10075 93611 127247 401036 79791 55585 57520 89910 51665 7337 51666 26091 55905 63891 63893 142686 991 57531 142685 55236 51676 142689 223082 22954 91694 10293 9666 51320 84676 80204 10616 7320 57542 51444 11146 135892 55008 6047 6049 23376 23014 57674 143279 25793 84231 11275 89122 57154 9320 11059 55819 64410 90025 222235 84937 140691 51465 54850 140456 140458 90933 140459 90135 25897 25898 9690 146330 9861 140460 8454 140461 6233 140462 7316 255488 114088 54620 23352 10213 868 5706 8916 23291 115290 5707 6737 5708 7704 5709 55958 8139 390594 5700 127544 5701 55284 5702 84961 5704 27246 5705 8924 122769 8925 5682 64320 5683 9354 81559 5684 55175 84708 5685 7174 27252 5686 5717 51130 5718 114907 642 5719 51132 26046 8945 11047 9903 5713 9246 5714 4591 25847 7979 158506 5690 92369 5691 55182 5692 126433 5693 26259 5694 64219 7311 7064 23304 5695 201456 7314 6500 80028 144699 899 5687 84861 5688 92912 10477 5689 26268 55070 90293 84727 92591 26263 26267 53339 10489 285231 89890 4012 9820 26235 26118 79176 26232 55521 84085 4008 9021 9817 51725 9039 26249 25831 8065 55658 140739 51619 9040 148581 79876 79754 84541 9730 154214 51191 151636 80176 23194 7428 9604 136371 10324 142678 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis 26270 22803 55294 6774 55135 6499 11328 10238 26330 10517 84261 7157 22948 63971 26985 26224 908 8841 54461 6950 898 7203 10528 26272 8877 83752 9134 10564 26234 10693 6468 10574 10694 10576 2629 10575 26190 DEGRADATION OF CRY AND PER PROTEINS%REACTOME%R-HSA-9932298.1 Degradation of CRY and PER proteins 5708 5709 5700 5701 7321 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 5187 8945 11047 8864 5713 8863 5714 1408 7979 1407 5690 5691 5692 5693 5694 7311 5695 9978 7314 6500 5687 5688 5689 26224 9861 8454 6233 7316 10213 5706 23291 5707 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622327 Postsynaptic nicotinic acetylcholine receptors 1137 1136 1146 1135 1134 1145 1144 89832 8973 1143 1142 1141 1138 55584 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 96%8874081 MET activates PTK2 signaling 3910 3911 3673 3912 3675 6714 3082 3688 3913 3914 3915 3918 4233 284217 10319 5747 3908 3909 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 7082 10207 2697 92359 64398 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190241 FGFR2 ligand binding and activation 2254 9982 2252 2251 143282 27006 83888 8074 2249 2248 2247 2246 8823 2255 8817 26281 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency 2937 SIGNALING BY TCF7L2 MUTANTS%REACTOME%R-HSA-5339700.5 Signaling by TCF7L2 mutants 1488 1487 6934 RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013423 RAC3 GTPase cycle 9341 55971 394 23092 57580 143872 347902 4810 397 55619 10787 85360 5062 7879 8936 5881 10152 10298 29 10652 64411 124056 3998 29127 9710 613 81839 51347 26050 3071 10163 28964 3688 22865 653361 23075 116984 2010 27035 23344 55114 143098 4952 10006 4983 23380 8987 55789 4162 7112 80728 4168 23191 55004 81624 2889 23592 11135 6510 1829 1969 55914 3930 998 7037 7074 27 857 182 7410 5295 5296 5058 8773 50508 395 1536 10811 1535 10458 7444 55843 10424 7204 10979 9743 9815 2909 4688 55845 57584 4689 392 9235 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 96%8949275 RUNX3 Regulates Immune Response and Cell Migration 3683 864 3676 865 6696 DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death 8331 8337 8334 84290 8335 5052 7001 4001 7531 8851 1020 351 2801 10018 8341 993 994 8342 841 356 8347 995 8348 8737 831 8345 11035 823 824 826 8340 6648 2309 3725 7186 23649 8338 5422 1789 1788 85236 1786 8349 5557 5558 708 1687 8717 197259 8370 2146 1029 3013 255626 3021 3018 3017 3014 474382 5931 8970 128312 94239 55766 8726 7157 8968 653604 23512 54145 5928 8772 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants 5156 DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963743 Digestion and absorption 11181 6476 8513 8972 8544 2980 280 119548 27159 1118 3938 278 2984 279 248 1056 2981 5406 5407 1208 5408 6523 6248 6514 6518 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance 6872 2963 2962 6874 2068 6873 5434 6908 5435 5436 5437 5438 5439 6881 2968 6880 2967 6883 404672 6882 5430 6884 5431 8148 5432 5433 902 6875 6878 83860 6877 2959 2958 6879 2957 54457 2961 2960 138474 5440 5441 4331 1022 2071 2966 129685 2965 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling 5335 2064 1956 1950 NEURODEGENERATIVE DISEASES%REACTOME%R-HSA-8863678.3 Neurodegenerative Diseases 84290 5052 7001 4001 7531 8851 1020 351 2801 10018 993 994 356 995 831 823 824 826 6648 2309 3725 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 96%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) 10568 DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME DATABASE ID RELEASE 96%5619081 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) 6531 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 23462 79885 3280 8850 9794 83933 7311 4851 9978 7314 6500 3066 5663 10046 5664 388585 55851 83464 23385 51107 26508 9612 9759 22938 3065 84441 1024 9734 2033 6907 4609 2648 9148 79718 28514 182 54492 57534 102 54567 6868 51564 3714 142678 8841 10013 9611 23493 10014 1387 3516 8454 6233 7316 55869 892 DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) 5002 PLUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164525.3 Plus-strand DNA synthesis 5478 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis 8907 130340 3105 567 10053 5062 1174 8905 375 162 55690 164 3932 1794 5879 920 160 161 163 51606 9844 3055 926 940 2534 1175 1173 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%191273 Cholesterol biosynthesis 6720 2224 2222 3157 6309 10654 6713 4597 1595 6721 1717 9453 4047 3422 4598 3930 7108 403313 1718 6307 50814 39 64801 10682 51478 91734 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function 2652 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) 4056 BIOFILM FORMATION%REACTOME DATABASE ID RELEASE 96%9931953 Biofilm formation 11045 4072 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 1351 1350 80010 1349 1107 2353 1347 1346 1345 55215 192670 27161 891 983 26523 1108 53632 1121 2475 22974 4869 9099 23112 5728 25946 57060 125965 57690 192669 11200 51230 79109 55240 1432 27165 27166 7534 10971 7533 5600 29117 4343 7529 3065 55615 124446 5562 5563 5564 5565 2033 613227 5571 27154 64223 57459 133383 10000 27327 5300 10498 7532 4697 207 51499 208 5305 1387 1386 5928 10769 56950 8178 129685 25904 6872 6874 6873 6908 7994 5052 6827 7001 6749 10650 6881 6880 7531 6883 54541 8851 55571 1020 6882 6884 8148 9150 6917 1025 5325 51497 11198 995 6875 6878 83860 246175 6877 8812 3725 6879 25920 54457 64065 51224 6921 6924 317 7936 6923 7469 138474 904 905 6794 7248 8621 4512 55004 8649 4513 4514 1263 64121 7249 58528 10542 389541 28956 57521 10670 6009 55367 153129 5366 835 10325 839 6446 5371 843 604 84701 5875 5876 10848 7157 3486 9997 7832 637 84289 80196 639 7862 2177 2176 355 7874 834 3276 8445 665 341947 53615 9540 23368 6790 85456 54205 79733 8795 5457 5458 8797 64769 23774 1820 54971 9337 8738 91875 7027 7159 8626 90809 1017 3066 55835 581 898 79370 7161 1616 9134 1027 57103 1026 7029 1869 9125 94241 117584 144455 1874 26013 9377 1643 28984 27113 8794 8793 1647 133746 2744 54815 387893 9656 58484 9891 83667 9167 147923 23019 50484 112858 3622 2539 6233 7316 5519 332 10397 5515 5516 2810 5518 9212 79813 2821 7295 26155 9219 5527 7296 57472 7311 5395 4194 8550 4436 7314 4292 890 4193 10919 5608 8396 204851 29883 5440 5441 4331 1022 2071 6829 2966 2965 1029 2963 2962 2068 5434 84883 5435 5436 7486 5437 5438 5982 5439 2877 5983 2968 8900 3364 2967 472 404672 5430 5431 672 5432 84126 5433 144715 902 83990 5810 5932 28996 1460 1459 9156 1457 5111 11073 5931 641 143686 6117 5984 5985 6119 63970 6118 1327 253260 5883 5884 116028 900 51422 51755 10419 1111 1329 83695 4850 10111 1340 5170 4361 4848 7156 1337 5892 4849 4683 580 5933 5934 10524 1339 1763 545 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 96%110381 Resolution of AP sites via the single-nucleotide replacement pathway 3980 5423 328 7515 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity 80010 7874 1107 8445 53615 6790 23368 983 1108 5457 5458 53632 2475 22974 23774 64769 54971 9099 91875 8626 7159 25946 90809 11200 1017 3066 51230 79109 7161 1616 1432 5600 29117 94241 3065 117584 55615 5562 5563 26013 5564 5565 2033 5571 64223 27154 57459 133383 10000 133746 5300 54815 387893 9891 207 208 5305 112858 3622 6233 7316 5928 56950 129685 6872 6874 6873 5519 6908 7994 6749 6881 6880 6883 8851 6882 1020 6884 5515 8148 5516 5518 9212 11198 79813 6875 6878 83860 6877 26155 9219 6879 5527 54457 7311 4194 8550 7314 890 4193 138474 10919 6794 5608 8396 204851 1263 1029 6446 7486 5982 5983 3364 8900 472 5371 672 84126 144715 83990 5810 5932 28996 1460 1459 9156 1457 11073 5931 641 6117 5984 5985 10848 6119 6118 7157 253260 5883 5884 116028 900 51422 10419 1111 84289 639 80196 83695 10111 5170 4361 7156 4683 580 7862 10524 1763 545 LEISHMANIA INFECTION%REACTOME%R-HSA-9658195.3 Leishmania infection 3553 10787 834 8936 718 10152 124056 3071 10163 3606 27035 63916 10006 4791 79792 1793 5879 3552 23191 1432 1398 9844 3055 5594 5595 998 5567 10093 5568 10092 10095 4210 10094 5025 10097 10096 1855 57105 111 10810 112 3162 113 114 115 2268 1857 1856 7454 7456 5747 2678 5027 64174 147179 10910 1511 3710 136 4907 2687 4620 2209 4650 346562 5575 7410 4641 1800 7525 10800 5573 2214 2212 7409 4651 4690 29108 644150 114548 26999 953 10451 5577 5336 4644 5613 79651 957 5576 10769 719 10109 9332 2534 8976 3586 4627 196883 6850 2771 808 2770 695 10552 2781 9051 2773 107 108 10768 71 109 3708 4790 51517 3709 5566 3326 7295 3725 5970 5045 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 94235 3569 55970 5599 10628 60 54331 5335 59345 917 4067 7474 6868 8324 2782 25 2778 10811 1535 10458 10681 55845 INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity 5708 5709 5700 5701 5702 5704 5705 11060 5682 8975 5683 81847 80243 5684 23252 5987 5685 8658 23608 80351 5686 5717 2444 5718 5719 11047 5713 5714 7979 5690 5691 10273 5692 5693 5694 7311 331 5695 7314 5728 5687 5688 5689 4734 1460 1459 1457 10000 207 208 9861 6233 7316 10213 5706 5707 ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells 3781 57053 3778 3779 55584 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 5395 5424 6119 4436 5425 4292 6118 2956 10714 57804 9156 5111 3978 6117 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism 10402 140838 29906 81849 51046 55808 6489 5476 10020 10825 2720 10610 6483 6482 6484 338596 6487 6480 10559 84620 256435 8869 30815 27090 55907 8128 26503 54187 80896 7903 4758 129807 4759 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling 639 1786 2033 3065 25942 3561 3066 29126 8841 6774 3091 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855204 Synthesis of IP3 and IP4 in the cytosol 808 5335 23007 27124 8867 4952 3633 3635 3636 9651 5332 5333 113026 84812 5330 3705 5331 5728 3706 51196 23236 3707 89869 122618 80271 5336 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 96%9673163 Oleoyl-phe metabolism 148811 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 96%9648025 EML4 and NUDC in mitotic spindle formation 80152 5903 2491 5519 332 55143 699 11243 140735 3619 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 79902 5347 5525 5526 55839 5527 5528 5529 140609 10783 91754 54908 6232 8655 25909 8379 9183 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 348995 348235 5048 23421 57122 220134 57082 57405 147841 51143 6249 7514 55746 4085 64105 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 1781 23122 1780 27436 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%427975 Proton oligopeptide cotransporters 51296 6564 121260 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B 4669 FERTILIZATION%REACTOME%R-HSA-1187000.4 Fertilization 347732 126123 2515 117155 79820 113177 928 2683 7783 378807 11085 49 7784 22917 100129669 157855 257062 117144 84329 284359 5016 6677 57828 8747 57829 8748 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission 2892 2890 27020 9177 8001 2774 80852 57576 2893 84254 5923 5924 28964 53632 5879 160 6714 4893 3265 6195 5594 5595 5567 5568 5562 5563 5564 5565 111 112 113 5571 114 3838 115 5578 5330 5331 23236 346562 5575 5573 88 22843 1740 2906 9647 8536 2905 814 5577 2903 4747 5613 2902 5579 5576 9495 196883 815 816 2771 808 817 2770 818 2773 107 108 109 4646 5566 6197 6196 4193 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 94235 55970 9463 3760 3761 2550 3084 3759 3359 55327 200909 3772 2562 2561 2560 2891 54331 2559 2558 2557 2904 59345 2556 2555 2554 2036 8973 26960 1143 3762 1142 3763 1141 3765 1138 3766 55584 3768 1137 27092 1136 7102 1146 2570 1135 23426 1134 2569 1145 4905 1144 2567 89832 2566 3773 8825 4900 51422 10645 55879 170572 10369 10368 5582 2782 8573 59283 5170 2743 2742 2900 2741 285242 2899 200959 2898 1742 320 27330 2897 83988 116443 10681 1741 116444 1739 23229 2901 64130 9568 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development 22938 3630 84441 2308 390874 256297 5080 6928 3280 6927 2033 50674 4821 4825 3170 8850 4760 3651 3175 389692 9794 3171 2645 222546 10000 3642 2648 4851 6514 10046 207 208 3174 1387 3516 2255 3375 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 96%209543 p75NTR recruits signalling complexes 4804 8878 7314 3551 7189 4803 6233 7316 3654 5584 8767 4615 7311 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade 2779 6295 5158 2782 1259 5148 1258 9187 2792 5145 6010 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%975871 MyD88 cascade initiated on plasma membrane 1147 5519 2353 4790 351 4792 5515 6197 6196 4793 5516 5518 841 8945 3725 7186 3654 8767 5528 4615 4791 57162 7311 5970 7314 6500 3551 84166 4205 10454 6285 7334 8517 6288 7335 11274 64127 7189 5608 6283 51295 257397 5609 3146 9261 51135 4214 23118 9683 6416 9684 5601 6195 7100 1432 5602 10392 5606 28512 79155 57161 79671 5594 177 5595 121457 246330 81793 5598 28511 3656 9097 2002 466 51231 5600 1849 7867 1848 1846 1845 5604 5599 7157 4208 9252 1386 8454 6233 7316 1326 6885 23291 80216 92610 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 6097 10499 10498 79718 1374 6604 6720 8204 8841 9611 96764 9572 6256 2033 1387 5465 23054 5469 85441 6095 6907 80205 8648 10891 SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 96%9669933 Signaling by kinase domain mutants of KIT 3815 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis 8331 3013 8337 8334 8335 255626 8341 3021 3018 8342 3017 8347 3014 8348 8345 8340 474382 5931 8970 23649 128312 8338 5422 1789 85236 1788 8349 94239 1786 55766 5557 5558 8726 8968 1687 653604 8370 23512 54145 5928 2146 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME%R-HSA-6802952.3 Signaling by BRAF and RAF1 fusions 10256 808 817 54518 818 8826 22866 7450 3690 5894 5037 2243 7094 5908 369 283455 408 10018 409 10533 6714 4893 3265 673 4140 5594 5595 5906 3674 7529 1185 5604 27044 5605 23164 8805 8546 57670 10827 10142 54845 56829 9444 9061 57085 9715 11044 55109 4000 22906 8087 55750 80853 2335 3717 2244 1445 2266 7414 815 8844 816 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium 57576 983 5347 6010 1258 55835 8655 10142 23332 22919 3320 5048 6991 64792 7840 6753 92104 9742 11064 23322 22994 22995 7283 27241 203068 55722 1453 54820 7532 9738 80776 79659 11190 5310 5311 261734 1781 23059 22920 95681 55212 51098 1778 117177 1069 28981 5577 403 51134 54801 9793 10540 51259 54806 4218 4735 79809 26160 11116 23265 92482 83657 150737 84902 84747 200132 83658 54930 7531 378 140735 60412 84100 5566 79959 54536 51668 5518 4867 2847 93323 9657 91147 22981 9371 55112 27077 80254 55755 10806 26146 85302 10121 10640 57539 11336 129880 89891 9662 149371 347240 11020 1262 55081 1260 22832 57787 6950 57545 7203 10733 80321 123016 55764 55125 55763 9814 3797 79738 8729 10694 8100 112752 10576 26005 115106 10575 166379 79441 55770 79600 26123 9702 79969 3842 5108 9321 50807 57560 55142 10383 22897 8195 10382 79598 5116 56912 80184 255758 11127 7846 6608 57728 51626 132320 6102 90410 8766 23354 146057 8481 582 583 54585 585 27031 121441 192668 79867 79989 7277 9727 55559 1454 22948 8636 4751 11258 84131 80173 54903 4957 10013 56623 5147 200894 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 96%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 10621 5434 6908 5435 5437 51082 84265 55703 112495 11128 51728 9533 9330 27297 661 2976 5440 10623 5441 2975 2972 2971 171568 55814 9328 9329 55718 10622 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 96%8941284 RUNX2 regulates chondrocyte maturation 3549 2736 865 9759 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 96%6811440 Retrograde transport at the Trans-Golgi-Network 9341 23647 22836 8774 8775 3482 79571 22796 9382 57589 10139 51560 143187 10618 60592 51209 25839 5870 9712 90196 10228 122830 84316 83548 400 63908 57511 60560 10466 9827 9367 8674 8677 8675 339122 6293 2800 51542 84342 738 91949 2803 7110 55275 10244 9648 4074 10226 4905 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins 11164 55270 56985 131870 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73776 RNA Polymerase II Promoter Escape 6872 2963 2962 6874 2068 6873 5434 6908 5435 5436 5437 5438 5439 6881 2968 6880 2967 6883 404672 6882 5430 6884 5431 8148 5432 5433 902 6875 6878 83860 6877 2959 2958 6879 2957 54457 2961 2960 138474 5440 5441 4331 1022 2071 2966 129685 2965 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6782315 tRNA modification in the nucleus and cytosol 152992 57604 51605 54517 93587 115708 90353 63892 57570 221078 54482 348180 127253 129450 23536 1787 55253 24140 55039 60487 54901 54802 2058 54888 54920 83480 10785 51504 113179 4234 112858 8270 134637 79691 81605 54974 55644 55621 51002 9836 84267 81890 84520 91801 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 96%430116 GP1b-IX-V activation signalling 7450 5894 7534 2812 2316 2815 2811 2814 5295 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 96%430039 mRNA decay by 5' to 3' exoribonuclease 25804 27258 23644 54464 51690 1656 196513 27257 167227 55802 11157 57819 80153 219988 23658 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane 23265 92482 84747 378 60412 84100 54536 2847 6010 10640 11336 129880 1258 149371 1262 1260 6950 7203 123016 55763 79738 8729 10694 10576 10575 166379 55770 79969 50807 8195 6608 6102 8766 582 583 6753 54585 585 27031 192668 9727 27241 22948 5310 5311 10013 55212 117177 56623 5147 403 200894 4218 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 96%174113 SCF-beta-TrCP mediated degradation of Emi1 5708 5709 5700 5701 991 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 6500 5687 5688 5689 26271 51343 9861 8454 6233 7316 10213 5706 5707 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME DATABASE ID RELEASE 96%9702518 STAT5 activation downstream of FLT3 ITD mutants 6777 6776 5292 1026 2322 9846 598 5781 50507 2885 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 1579 1545 113612 1558 8529 1559 1557 1544 1543 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression 8331 8337 8334 3276 8335 2353 192670 27161 8341 8342 8347 8348 8345 26523 8340 2354 8338 85236 8349 23112 57690 595 192669 200845 8370 4343 3013 3065 255626 3021 3018 2033 3017 3320 3014 9126 3838 474382 8312 8648 8970 4435 128312 27327 10499 10498 55766 6387 8968 3727 8204 653604 1387 10735 1386 5469 51523 1105 1509 23028 2288 5451 8202 23030 7764 1655 7090 3169 9166 6908 9687 23189 2494 7033 7392 10274 7039 7391 7031 861 10728 865 1025 3326 8243 8850 5885 2958 3725 2957 904 5241 2099 5440 5441 7528 2625 2963 2962 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 6667 4609 596 57678 94239 54145 4602 10524 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373760 L1CAM interactions 3672 3912 3673 3688 6456 1463 5879 1213 1211 6386 160 161 163 6195 5594 5595 1175 1173 5604 5605 3685 7410 8829 3690 1956 8650 6197 24137 6196 6900 27255 11280 2048 3897 10752 8828 1759 1641 5962 1808 3785 4478 3786 3680 6708 6709 55800 8986 285643 6324 6323 1272 286 287 288 100133941 2596 51332 6711 6710 4897 6712 11313 6331 6330 6332 6335 6334 26052 214 6326 8506 6328 6327 6329 7430 4684 23114 3674 57698 57731 6336 3678 8515 10048 3312 1460 1459 1785 1457 5058 9252 3915 1742 27330 284217 1741 1739 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 96%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 22916 84967 6634 7884 4686 6636 134353 6635 6637 25888 6628 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation 8331 8337 8334 8335 861 192670 27161 8341 8342 8347 8348 4853 8345 4854 8850 4855 26523 8340 9794 3725 5584 8338 85236 4851 8349 1991 23112 7027 57690 595 192669 10046 1871 8370 7029 1869 4343 3013 22938 84441 255626 100996717 51548 1999 100996763 388677 3021 3018 2033 3017 3014 474382 8970 128312 27327 2648 94239 55766 7157 8968 653604 1387 3516 54145 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-HSA-5654687.4 Downstream signaling of activated FGFR1 23767 4893 6654 2254 23768 3265 23769 5781 2251 27006 5295 8074 2249 2248 2247 10817 5290 2246 5335 2549 2255 10818 26281 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702506 Drug resistance of FLT3 mutants 2322 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA 3030 33 3032 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation 3065 7994 1107 5371 53615 2033 27154 1108 57459 5931 9219 10000 23774 64769 5300 54815 7157 90809 3066 5608 8396 207 208 5305 84289 3622 5928 7862 29117 SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM 2963 22916 2962 5434 5435 4686 5436 5437 5438 5439 5430 5431 5432 5433 2263 2247 2246 5440 5441 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112315 Transmission across Chemical Synapses 28964 53632 5879 160 6714 4893 6531 3265 6511 6195 27165 5594 5595 6506 6505 6507 81539 5567 5568 5562 5563 6512 5564 6539 5565 54407 111 112 113 5571 114 115 346562 5575 88 22843 1740 2906 9647 8536 2905 814 5577 2903 4747 5613 2902 5576 9495 196883 2771 808 2770 2773 107 108 109 4646 60482 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 94235 55970 9463 3760 3761 2550 6844 3084 6616 3759 3312 6857 6804 3359 55327 200909 3772 2562 22999 2561 590 2560 54331 8541 2559 18 2558 2557 1103 59345 2556 43 2555 27163 2554 140679 7915 2036 8224 26960 3762 5864 3763 80331 3765 6854 3766 6853 1312 3768 8497 27092 8499 7102 10815 2570 10497 220074 23426 2569 6532 4905 773 2567 774 2566 777 3773 6529 8825 9256 4900 6540 10645 9254 781 55879 170572 782 783 10369 784 10368 785 5582 2782 8573 6538 59283 8500 2743 57030 2742 2752 2900 2741 6571 285242 6572 2899 200959 10550 2898 1742 320 6582 27330 6580 2897 83988 116443 55799 10681 1741 116444 23229 1739 2901 64130 9568 2892 2890 27020 9177 8001 2774 80852 57576 2893 84254 5923 5924 2572 2571 217 3838 2744 5578 5330 5331 23236 4128 5573 5579 815 816 817 818 5566 6197 6196 4193 2891 2904 8973 1143 1142 1141 1138 55584 1137 1136 1146 1135 1134 1145 1144 89832 51422 5170 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) 85015 8607 54107 9557 125476 10980 93973 29844 54891 79913 9318 50813 54617 10038 2067 10920 283899 83444 5886 5887 4798 2873 7507 10445 51138 7508 3978 10987 7311 9978 7314 7336 7334 7341 86 8554 4331 1022 2071 6612 7528 2966 7329 2965 6613 2068 3980 10401 142 5981 7515 5982 5983 2968 2967 404672 56655 902 60 1643 8451 8450 5111 1642 6117 5984 5985 5424 6119 5425 6118 5426 5427 10714 51426 1069 57804 6233 7316 8533 2073 2072 64708 54778 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 96%73929 Base-Excision Repair, AP Site Formation 8331 3013 8337 8334 8335 255626 8341 3018 8342 3017 8347 26277 3014 8348 8345 25913 4350 8340 474382 8970 128312 8338 85236 8349 94239 55766 54386 8370 8290 8930 55247 54145 23583 7013 252969 65057 4968 7014 79661 6996 4913 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism 5019 64064 56898 79611 54511 38 3158 65985 622 3155 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%5662702 Melanin biosynthesis 51151 4948 7299 7306 1638 DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication 8331 54107 8337 8334 51529 7321 8335 8881 64682 25906 11065 8697 7324 84515 5000 10393 29945 8341 5001 27338 23594 119504 8342 23595 29882 4998 8347 4999 8348 246184 8345 996 51434 51433 8340 23649 8338 5422 85236 8349 5557 5558 56652 246243 11232 5428 1017 5442 29935 10926 898 81620 92667 9941 51343 6502 2237 51053 9134 55388 8370 6742 23633 3013 255626 3021 3018 3017 3014 3837 474382 8970 128312 55766 8317 8968 653604 9861 8454 6233 7316 10213 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 3978 4172 5714 4173 7979 4174 5690 4175 5691 4176 5692 5693 64785 5694 8318 9837 7311 84296 4171 5695 9978 51659 7314 6500 890 5687 5688 5689 5981 5982 5983 8900 56655 990 5111 6117 5984 5985 5424 94239 6119 5425 6118 5426 5427 10714 57804 7156 54145 3836 1763 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants 3815 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 6222 6224 6218 6217 6230 6231 6234 6235 6191 6193 1965 8894 6192 6194 1968 6227 6229 6228 1975 1978 1977 3921 1981 1974 1973 8662 8663 8661 8666 8667 6232 8664 8665 27335 3646 51386 7458 8668 8669 10480 1964 2197 140032 6201 6203 6202 26986 6210 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 GSD 0%REACTOME%R-HSA-3858516.4 GSD 0 8908 2998 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654693 FRS-mediated FGFR1 signaling 4893 6654 2254 3265 5781 2251 27006 8074 2249 2248 2247 10817 2246 2255 10818 26281 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 51750 54107 5888 80010 5889 2067 8341 8342 8347 8348 8345 8340 85236 8349 7336 7334 1017 8370 255626 7468 29086 9025 51720 54962 63967 151987 84142 165918 7158 3018 5893 3017 5531 3014 9577 79184 8914 6047 8970 128312 9656 6233 7316 8924 3978 7979 7311 7314 890 8290 51588 7329 6613 348654 7486 5981 51548 5982 5983 3364 8900 472 56655 672 675 84126 144715 83990 5810 7516 5932 7517 9156 5111 11073 80198 641 55732 79008 6117 5984 5985 5424 6119 5425 79728 6118 5426 5427 5429 5883 5884 116028 10635 10714 146956 1111 197342 83695 84464 10111 51426 57804 25 4361 7156 54145 5890 5892 4683 580 23514 63979 10524 1763 2072 545 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 96%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 6097 6096 96764 2033 6907 80205 8648 10891 4862 10499 10498 79718 6604 4208 4209 9575 8204 64784 8841 9611 23411 9572 200186 6256 1387 23373 5465 23054 1386 5469 85441 6095 406 10743 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events 808 817 818 9630 107 5567 108 10768 109 5568 3708 84254 3709 5566 111 112 5580 113 5321 3838 114 156 115 5137 5153 5136 26960 2767 5578 5332 3710 2769 5330 5331 23236 5575 10645 5573 2776 5582 5577 814 5594 5613 5576 196883 815 816 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines 8331 3013 8337 8334 8335 3276 6601 6603 6602 6605 8289 55193 3014 474382 5931 10196 317772 54496 8338 92815 85235 8969 1788 94239 221613 55766 10498 55352 6604 8968 1019 595 86 10419 51412 653604 79084 8370 11091 196528 57492 6595 3717 55170 6597 6187 6599 6598 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 96%9665244 Resistance of ERBB2 KD mutants to sapitinib 3320 55914 2064 11140 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%R-HSA-3304351.4 Signaling by TGF-beta Receptor Complex in Cancer 4087 4088 4089 7046 7048 7040 2280 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 96%1679131 Trafficking and processing of endosomal TLR 1513 81622 7098 51284 1520 1515 5641 51311 1508 54106 7184 1514 INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166663 Initial triggering of complement 721 629 717 718 4153 2220 1401 1675 3004 712 78989 713 714 8547 715 10584 716 5648 2219 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-HSA-74751.5 Insulin receptor signalling cascade 3630 117145 2549 5140 9965 4893 57761 6654 5289 2254 3265 2252 5781 2251 208 27006 8074 5295 2249 5296 2248 2247 2246 5290 152831 5170 8823 5291 8660 5594 30849 5595 2264 2255 2887 2323 2322 6464 54106 10818 3643 9846 3667 8817 26281 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 96%9665249 Resistance of ERBB2 KD mutants to afatinib 3320 55914 2064 11140 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-HSA-1834949.6 Cytosolic sensors of pathogen-associated DNA 5591 10621 81844 1147 11277 9447 170506 51428 340061 3428 3665 4790 9208 6778 197358 4792 4793 8737 11035 4615 4791 7311 5970 1499 7314 3551 8517 148022 28512 5440 5441 28511 5434 5435 5437 22954 2033 29110 147945 3661 23220 81030 7098 51082 84265 55703 11128 51728 1387 9533 27297 661 4361 10623 6233 7316 171568 7520 1660 2547 55718 115004 10622 6737 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME%R-HSA-9909615.2 Regulation of PD-L1(CD274) Post-translational modification 8452 5708 5709 5700 5701 5702 5704 5705 10613 5682 100128731 5683 5684 5685 5686 5717 5718 91445 5719 6048 8945 11047 5713 10987 5714 53632 7979 5690 5691 91319 5692 5693 5694 10956 7311 5695 9978 7314 6185 6500 5687 6184 5688 1019 595 2932 5689 746 1603 27248 79139 51009 6400 84061 5562 5563 5564 5565 80380 1460 5571 1459 7991 1457 201595 8405 3703 3716 1650 11160 10331 4751 7532 29126 142678 51422 7415 9861 5133 8454 6233 7316 58505 10213 5706 5707 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 96%204005 COPII-mediated vesicle transport 2890 8774 8775 1294 7039 79090 10652 5265 2801 6399 3998 5861 23243 22870 2153 22872 2348 10175 5537 10972 9554 9117 63908 11196 64689 126003 55291 23256 1075 58485 254263 25956 55014 81562 51693 2157 122553 8615 966 10342 27095 149111 9919 81876 83696 10959 6811 10113 90411 10282 26984 9570 51399 89866 79748 7109 128637 10960 1522 51128 374 9871 9632 10427 4905 1453 6396 10802 10484 MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702600 midostaurin-resistant FLT3 mutants 2322 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9940951 Interaction of NuRD complexes with transcription factors 8331 8337 8334 8335 1107 53615 8341 8342 8347 8348 8345 8340 1108 9219 8338 85236 8349 3066 8370 5105 57504 8099 26038 55205 9112 6941 22806 22807 3013 57592 23613 3065 10263 7182 8932 255626 9640 7026 10320 152485 84295 3021 3018 3017 3014 474382 57459 5931 8970 128312 54815 94239 55766 8968 653604 2203 54145 2538 5928 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 96%5579030 Defective CYP19A1 causes AEXS 1588 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis 11343 10125 3708 3709 5581 5583 9162 8527 26090 8525 8526 57406 221955 5580 160851 1609 747 1608 1607 1606 139189 7222 3710 7225 5588 10235 57113 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 808 814 5566 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 6872 2963 2962 6874 2068 6873 5434 6908 5435 5436 5437 5438 5439 6881 2968 6880 2967 6883 404672 6882 5430 6884 5431 8148 5432 5433 902 6875 6878 83860 6877 2959 2958 6879 2957 54457 2961 2960 138474 5440 5441 4331 1022 2071 2966 129685 2965 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5658623 FGFRL1 modulation of FGFR1 signaling 2249 2248 2247 161742 2255 200734 53834 8817 27006 8074 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 96%444821 Relaxin receptors 122042 117579 6019 339403 59350 51289 3640 10022 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%9675136 Diseases of DNA Double-Strand Break Repair 5888 80010 5889 7486 5982 5983 3364 472 672 675 84126 144715 83990 5810 7516 5932 9156 11073 7979 641 6117 5984 5985 6119 79728 6118 5883 5884 116028 10635 83695 10111 4361 7156 5890 5892 4683 580 10524 1763 545 RHOB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013026 RHOB GTPase cycle 9341 70 394 23092 10395 57580 6093 10276 5099 9138 388 398 128239 10211 1729 11214 29 9475 29127 613 81839 2319 7984 23263 4983 55789 4162 80728 4168 81624 9414 55914 7037 857 6793 65124 4650 5585 5586 55160 7410 23002 23365 115557 9181 29941 85415 5295 1894 5296 4649 8773 6242 9754 2040 3728 54443 9748 9826 11113 90627 9743 64283 2909 9828 284119 57584 50650 392 9639 ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 96%428540 Activation of RAC1 8440 9353 5879 6091 5062 6654 10298 56924 4690 5058 6655 5063 57144 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events 695 57580 6093 10276 9138 388 11214 128272 26230 121512 29 5924 84904 9475 100271715 25791 89846 6915 54848 26084 22899 50649 5364 8874 8997 64857 6453 2768 7984 57449 389337 445328 2245 221472 55701 10672 23263 9459 146 389 147 148 2793 2792 2791 4168 2790 6654 27237 2788 2787 2786 2785 2784 2783 51764 94235 55970 7074 54331 59345 55160 7410 387 23365 23370 9181 7409 1894 2782 10451 9826 7204 10681 9828 6655 23229 50650 9639 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids 26063 1962 122970 215 11001 3295 30 10005 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease 5156 23189 4893 2803 6654 6772 3791 3265 6774 81608 2120 5295 51411 5296 6801 5290 5291 57599 S PHASE%REACTOME DATABASE ID RELEASE 96%69242 S Phase 54107 51529 7321 8881 64682 25906 11065 8697 7324 84515 5000 10393 29945 5001 27338 23594 119504 23595 29882 4998 4999 246184 996 51434 51433 23649 5422 5557 5558 7027 1019 595 2932 1017 898 81620 51343 6502 91768 2237 7465 51053 286826 9134 4149 114799 132660 1027 1026 91750 1163 5753 7029 1869 55957 157570 5925 23047 1875 1874 113130 9126 10000 207 208 23244 10735 9861 8454 6233 7316 5928 10213 5706 5707 5708 5709 5700 5701 5702 23063 5704 5705 10274 5682 5683 5684 993 5685 994 5686 5717 8243 5718 5719 11047 5713 3978 4172 5714 5885 4173 7979 4174 5690 4175 5691 4176 5692 5693 64785 5694 8318 9837 7311 84296 4171 5695 9978 51659 7314 6500 890 5687 5688 5689 4331 1022 5981 5982 5983 8900 56655 902 990 5111 4609 6117 5984 5985 5424 6119 5425 6118 5426 5427 10714 57804 5934 1763 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375280 Amine ligand-binding receptors 153 154 155 3358 3357 3356 1133 3355 1816 83551 1815 1814 1813 1812 134864 319100 134860 9038 1132 3354 1131 3352 3274 3351 3350 1129 1128 3269 11255 4935 146 147 148 150 151 152 9287 3363 3362 3361 3360 59340 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%5693532 DNA Double-Strand Break Repair 51750 54107 5888 80010 5889 10038 2067 8341 8342 8347 8348 8345 8340 85236 8349 7336 7334 11200 1017 2237 8370 3980 142 255626 7468 29086 7515 9025 51720 54962 63967 151987 84142 165918 7158 3018 5893 3017 5531 3014 9577 79184 8914 3838 6047 8970 128312 5536 22976 8314 55183 9656 27343 51035 2070 51567 7518 8467 9031 322 79840 55775 3981 9682 64421 27434 2140 2139 2138 10721 6233 7316 7520 2547 23030 5591 8924 3978 7979 7311 7314 890 7341 8290 51588 7329 6613 348654 7486 5981 51548 5982 5983 5599 3364 8900 472 56655 672 675 84126 144715 83990 5810 7516 5932 7517 9156 5111 11073 80198 641 55732 79008 6117 5984 5985 5424 6119 5425 79728 6118 7157 5426 5427 5429 5883 5884 116028 10635 10714 146956 1111 197342 83695 84464 10111 51426 57804 25 4361 7156 54145 5890 5892 4683 580 23514 63979 10524 1763 2072 545 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9759475 Regulation of CDH11 Expression and Function 192670 27161 26523 6667 9839 51129 27327 1500 1499 23112 57690 192669 26508 2294 56978 3728 8728 64403 1495 27319 80332 1006 3224 3609 6615 4343 1009 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME%R-HSA-4341670.3 Defective NEU1 causes sialidosis 4758 5476 2720 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 5087 9787 22938 23129 23462 171558 23286 84441 10460 4904 1956 11060 6772 3280 2033 4854 8850 9794 1950 7311 2648 4851 7314 9148 28514 182 54492 57534 102 54567 5663 142678 3714 10046 5664 388585 55851 83464 23385 23493 51107 1387 26508 3516 2173 6233 7316 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS 8452 695 6093 3718 1107 3554 7297 3570 79685 8819 1901 10728 6773 53615 9475 3460 29760 3459 51185 973 3326 8737 23186 974 3454 3688 51742 10280 1108 10284 2342 9219 64426 25855 2339 5926 10362 51317 9978 30011 5045 23476 160 161 3066 163 6654 59272 2908 5978 57504 1175 9817 1173 9112 3676 3065 3320 29110 57459 5931 81030 476 477 478 53822 1312 54815 3716 53826 203068 51284 53828 4780 480 481 10800 482 483 7409 486 4690 3615 3614 5348 5133 5336 5349 5928 23028 54106 3717 2288 2280 6850 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs 8106 11051 22916 10978 10898 1479 51692 1478 1477 4686 23283 10914 53981 51585 29894 55339 81608 79869 8189 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662361.2 Sensory processing of sound by outer hair cells of the cochlea 5756 3781 57053 3778 3779 5962 4478 6709 6711 129446 25861 161497 124590 51168 11344 64072 4647 53904 494513 9750 259236 65217 23136 339768 117532 117531 7430 25794 283310 643226 340990 286262 375611 4354 10518 5357 53405 10083 64787 222662 83715 9132 389207 2059 140469 2934 2036 55584 4641 8573 4627 DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS 6440 IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME%R-HSA-9709275.2 Impaired BRCA2 translocation to the nucleus 7979 675 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR 374 1956 7039 685 1950 255324 2069 1839 POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764790 Positive Regulation of CDH1 Gene Transcription 11171 55810 687 3170 93986 6667 9839 5925 9314 7020 8289 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 2249 2247 2246 2260 2254 2251 26281 8074 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters 57468 6560 10723 6557 6559 6558 9990 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 96%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 2683 176 4060 5549 4969 4958 11081 2331 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage 3251 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA 5708 5709 5700 5701 3304 5702 5704 5705 5682 5683 3312 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 3315 5693 5694 7311 5695 7314 5687 5688 5689 26986 1981 9861 6233 7316 10213 5706 5707 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors 4481 2495 117156 81035 7184 1284 1282 78989 1281 2512 1278 1277 348 5648 335 811 338 286133 8685 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol 84335 1147 572 842 4193 2932 207 208 23608 1027 1026 7249 2931 10000 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME%R-HSA-9699150.3 Defective DNA double strand break response due to BARD1 loss of function 580 672 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 96%159424 Conjugation of carboxylic acids 10249 123876 341392 219970 92292 54988 116285 389396 348158 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013409 RHOJ GTPase cycle 9341 394 23092 57580 128239 85360 5062 7879 11060 10298 81839 28964 8874 143098 4952 4983 55789 7112 2697 55004 81624 11135 55240 6510 998 7037 7454 147179 857 23048 91010 57381 54874 5295 2631 5296 144402 5058 8773 8476 81704 2040 9497 3728 9578 23513 200894 7204 9743 9815 2909 8976 57584 5063 392 SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 6692 3249 4485 4486 10653 CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME%R-HSA-9833576.1 CDH11 homotypic and heterotypic interactions 1500 1499 3728 64403 1495 1006 1009 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%1614635 Sulfur amino acid metabolism 23743 51380 4507 2326 1036 875 58478 6821 635 84245 2806 2805 23474 339896 1491 51074 55256 1468 4357 84890 4143 4552 191 4548 7263 25828 58472 100131187 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 6222 6224 6181 6218 6217 53918 6059 6230 6231 6234 9349 6235 6191 6193 7311 6192 6194 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins 5591 3105 7321 56254 7332 7324 8341 8342 8347 8348 8345 92305 6596 8340 23168 9781 79577 51322 5195 80349 5192 7319 5193 7311 5194 85236 5828 123169 7314 51255 7322 7336 9646 257218 55829 7334 9810 118424 220441 54623 8915 79139 10670 255626 3018 3017 7320 56852 5111 8970 7323 7415 6233 7316 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 96%168138 Toll Like Receptor 9 (TLR9) Cascade 2353 841 7186 8767 4615 4791 57162 84166 4205 10454 7334 6285 7335 929 6288 11274 8411 7189 64127 80231 353376 6283 148022 3146 3663 51295 257397 51135 9261 64145 4214 23118 9683 9684 6195 1432 10392 28512 79155 57161 79671 5594 177 5595 121457 246330 28511 3656 9097 466 5600 51231 1849 7867 1848 1846 1845 5604 23643 4208 51284 7099 1386 8454 6233 7316 1326 6885 23291 80216 92610 1147 5519 3665 4790 351 4792 5515 6197 6196 4793 5516 5518 8945 3725 3654 5528 7311 5970 7314 6500 121260 3551 8517 5608 5609 6416 5601 5602 5606 5598 2002 5599 7157 5289 9252 30849 54106 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9918485 Dengue Virus Attachment and Entry 6382 2719 79876 55236 221914 9672 2239 7318 7317 10533 5045 3339 160 161 929 163 2262 7301 2621 5295 558 4360 22924 3921 440400 9076 30835 4061 51234 2817 10461 945 26762 3309 5627 6383 91937 10082 1175 11314 6385 1173 375790 9039 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 96%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 22949 4056 126410 240 1580 241 57834 246 2687 284541 1800 9261 4048 1579 8529 4051 2678 4363 64174 11283 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167243.5 Tat-mediated HIV elongation arrest and recovery 2963 2962 5434 5435 5436 5437 6827 5438 6749 5439 5430 5431 5432 9150 5433 6917 1025 51497 11198 25920 51224 6921 6924 7936 6923 7469 904 5440 5441 6829 8178 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway 4248 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME%R-HSA-9824585.3 Regulation of MITF-M-dependent genes involved in pigmentation 25924 8110 7391 3662 6601 8193 6603 26039 6602 6490 6605 5977 8289 6760 6663 5873 79083 9274 60 9275 2315 605 54843 4935 1499 7299 6604 7306 1638 51176 208 86 1432 4644 57492 6595 6597 6599 7020 6598 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 96%983712 Ion channel transport 1185 65125 63982 1187 23200 203859 476 1186 477 1184 478 1183 1182 53822 1181 133308 1180 79895 53826 57101 11059 5350 1179 479 53828 150159 51761 7439 480 51802 1193 22802 481 219931 2281 286410 482 9635 483 338440 486 57198 487 57194 488 1188 444 489 10786 285175 65266 5348 65268 5349 6233 65267 10345 7316 285335 495 6717 490 496 491 144453 492 10110 493 9914 10079 815 538 816 808 55107 817 818 94015 6263 57130 6262 23678 540 6588 28962 5205 5894 6261 55515 40 41 266675 23400 374868 54831 23120 55129 50636 9311 161003 259232 84239 7809 23250 284525 196527 57719 57205 1831 344905 10396 6340 51248 7311 80727 148229 27032 7314 57578 121601 51076 53373 6337 6339 6338 245972 245973 155066 9114 51606 9550 523 525 526 527 528 529 8992 90423 127124 23545 51382 533 6446 534 535 537 10312 50617 9296 7220 7442 7222 7224 7223 7226 7225 59341 79054 55283 23327 26133 54795 8989 55503 4308 162514 255231 57192 51393 80036 56302 57113 29850 2040 54822 140803 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-3232118.9 SUMOylation of transcription factors 1029 6613 7157 10401 4193 6670 3090 668 7341 4286 7158 7022 7021 8554 51588 6612 9112 7329 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 3329 4869 4839 7020 4605 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function 5888 80010 5889 7486 472 672 675 83990 7516 5932 9156 7979 641 79728 116028 10635 10111 4361 7156 5890 5892 4683 580 10524 1763 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination 6222 6224 6181 6218 6217 6230 6231 6234 9349 6235 6191 6193 7311 6192 6194 51121 6227 6229 6228 11224 200916 6122 6124 327 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 29104 23708 6203 6169 6202 51504 116832 6160 6161 2107 6175 9045 2935 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat 2963 22916 2962 2068 5434 5435 4686 5436 5437 6827 5438 6749 5439 2968 2967 404672 5430 5431 5432 9150 5433 6917 1025 902 51497 11198 8812 25920 51224 6921 6924 7936 6923 7469 904 905 5440 5441 4331 1022 2071 6829 8178 2966 2965 LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5632681 Ligand-receptor interactions 2619 3549 6469 50937 50846 64399 5727 91653 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69109 Leading Strand Synthesis 5424 5425 5557 5558 5981 5982 5983 10714 57804 5111 23649 5422 5984 5985 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 96%1483166 Synthesis of PA 5338 10554 253558 5319 10555 8443 22925 200879 64600 5337 23259 23171 100137049 84895 254531 150763 79888 149998 2819 30814 5321 248 57678 8399 374986 5320 137964 5322 26279 283748 201164 81579 84803 55326 2820 80821 56894 56895 51205 ASSEMBLY OF THE HIV VIRION%REACTOME%R-HSA-175474.3 Assembly Of The HIV Virion 55048 5478 89853 7314 5045 155382 137492 93343 7251 51271 79720 9397 6233 7316 7311 51160 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility 2064 1729 1956 387 3084 9542 51072 10718 145957 685 1950 2069 1839 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) 22987 9899 6843 9900 6844 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity 51085 79602 6794 9370 5563 51094 51422 5565 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression 3673 1729 192670 27161 891 25942 26523 5347 4233 1499 999 7299 23112 7306 1638 57690 595 1017 192669 86 1432 1026 6595 6597 3094 6599 6598 4343 3065 25924 8110 3662 6601 8193 6603 26039 6602 6490 6605 5977 6760 8289 2766 6663 5873 79083 5454 9274 9275 2315 605 54843 201595 10891 4935 27327 5054 83439 6604 51176 208 23411 4644 7020 7391 994 3978 4174 4171 9114 51606 9550 523 526 57492 527 528 529 8992 1029 533 672 60 6657 23405 596 597 6909 634 7837 5829 1000 10085 427 6935 727936 7015 79444 4308 6932 6934 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602571 TRAF3 deficiency - HSE 7098 7187 148022 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 23462 79885 3280 8850 9794 83933 7311 4851 9978 7314 6500 3066 5663 10046 5664 388585 55851 83464 23385 51107 26508 9612 9759 22938 3065 84441 1024 9734 2033 6907 4609 2648 9148 79718 28514 182 54492 57534 102 54567 6868 51564 3714 142678 8841 10013 9611 23493 10014 1387 3516 8454 6233 7316 55869 892 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis 5434 5435 5436 5437 5438 5439 5430 5431 5432 5433 3320 221400 122402 55124 84944 54456 143689 11022 91646 54514 4603 113802 8468 9271 56165 136991 5440 5441 201164 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112412 SOS-mediated signalling 8660 4893 6654 3265 3667 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876493 InlA-mediated entry of Listeria monocytogenes into host cells 1500 1499 7314 999 6233 6714 7316 79872 7311 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin 5708 5709 5700 51529 5701 7321 5702 5704 8881 64682 5705 25906 11065 5682 8697 5683 7324 5684 10393 29945 27338 5685 119504 5686 29882 5717 5718 246184 5719 996 11047 51434 5713 51433 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 5689 991 9861 9232 6233 7316 10213 5706 5707 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9613829 Chaperone Mediated Autophagy 7314 1915 3312 5116 10013 3320 3043 3326 10226 1080 6233 200894 8100 6035 7316 2670 123 1068 3920 11315 7311 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 96%5661231 Metallothioneins bind metals 4495 4496 4499 4489 4501 4502 4504 84560 4490 4493 4494 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair 55247 4968 79661 4913 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters 83439 1499 864 4609 8313 51176 6932 6934 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle 92421 23636 9972 9631 27243 7175 11097 128866 23511 8086 8021 10015 53371 8480 1104 10762 8815 1234 5902 4836 79643 51652 29082 91782 25978 2237 348995 57122 55746 7514 23279 79023 7518 6396 5901 3981 7852 6233 7316 7520 5905 2547 9525 8178 129685 51160 6872 55048 22916 89853 5903 5478 6874 6873 6908 155382 4686 137492 27183 6827 6749 93343 6881 7251 6880 51271 6883 79720 6882 6884 51510 8148 51534 9150 6917 1025 51497 11198 6875 6878 83860 6877 8812 3978 79902 2959 2958 6879 2957 25920 54457 2961 2960 7311 51224 6921 6924 7314 5045 7936 6923 7469 138474 904 905 5440 5441 8732 4331 8731 1022 2071 6829 2966 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 9397 920 23327 9883 129401 9688 23225 3836 4927 3159 23165 11168 55706 DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) 60482 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME DATABASE ID RELEASE 96%9820962 Assembly and release of respiratory syncytial virus (RSV) virions 3320 3326 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 96%210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 2752 81539 6506 6507 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA 167227 207 5393 11340 22894 23016 1432 8570 23404 5073 51010 54512 51013 7534 56915 118460 5600 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 96%418889 Ligand-independent caspase activation via DCC 26060 842 836 1630 1613 1612 23604 219699 9500 90249 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 84661 9070 11091 8085 5929 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation 1029 5519 117584 7874 6446 55615 8900 472 5515 5516 5518 983 64223 10000 2475 5527 7311 4194 7314 7157 9099 890 4193 253260 1017 11200 51230 900 79109 207 208 80196 1616 5170 6233 7316 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate 6888 7086 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 96%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 6382 3339 2719 221914 2262 9672 2239 2817 6383 10082 6385 2132 375790 2131 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 96%68877 Mitotic Prometaphase 891 983 5347 85378 64151 10426 10592 29922 27229 9918 23397 440145 80097 55835 10051 4926 114791 27175 653784 10844 54908 6232 8655 25909 8379 9183 23047 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 10142 23332 79003 55055 81565 22919 3320 113130 348995 348235 9126 5048 23421 57122 220134 57082 7840 57405 147841 51143 6249 11064 55746 7514 4085 22994 9133 22995 64105 7283 401541 23279 203068 79023 55722 10403 1453 54820 7532 9738 80776 701 11190 54821 6396 378708 1781 23122 23244 95681 1780 27436 79172 1778 81930 1069 10735 55920 5577 84643 3796 54801 9793 10540 91687 57551 79682 5905 1783 5501 83540 11116 80152 5903 2491 5519 332 55143 23063 699 11243 54930 7531 10274 140735 3619 5566 5515 79959 11004 5516 5518 9212 25936 93323 8243 11130 64946 22981 79980 10726 79902 5885 80254 5525 55755 5526 10806 55839 5527 5528 10121 5529 9662 140609 10783 10733 91754 80321 55125 9814 115106 79441 9702 5108 55142 10383 22897 10382 5116 80184 7846 1460 1459 1457 23354 8481 55732 121441 7277 55559 1454 8636 4751 11258 84131 4957 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 96%5668599 RHO GTPases Activate NADPH Oxidases 5879 5590 5289 124056 5880 1432 6279 50508 6280 5580 1536 10811 653361 5594 30849 1535 5595 27035 5579 4688 5578 4689 5300 5600 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 96%3248023 Regulation by TREX1 11277 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA 6296 35 1892 3033 142827 CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) 8331 285051 3013 8337 8334 8335 255626 8341 3021 3018 8342 3017 8347 3014 8348 8345 8340 474382 8970 128312 8338 85236 8349 94239 55766 8968 10765 653604 8370 54145 200424 29128 5927 359787 124512 23135 57379 7403 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.1 Defective FV causes thrombophilia 5624 2153 5627 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation 10621 5434 5435 5437 51082 84265 55703 11128 51728 9533 27297 661 5440 10623 5441 171568 55718 10622 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 96%933541 TRAF6 mediated IRF7 activation 64135 3442 3441 3440 23586 80143 3456 84282 3665 57506 3452 3451 3449 3448 3446 3445 3444 2033 3443 7706 29110 3661 7186 89122 9641 7189 10010 1387 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 96%9772573 Late SARS-CoV-2 Infection Events 55107 3276 100128731 55129 50636 196527 57719 7311 7314 5045 6185 121601 6184 2932 746 1603 7341 7113 59272 7329 821 84061 11282 7841 29801 6733 2589 25921 6732 253832 54956 51201 7991 143 55741 2931 63982 11320 56965 51125 83666 201595 4247 79668 203859 84875 51304 3703 4249 54625 10610 6483 6482 6484 6487 4245 1650 4124 57101 6480 25834 1452 23193 256435 79844 2530 27090 11253 5589 51114 338440 6233 7316 58505 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 96%4719377 Defective DPM2 causes CDG-1u 54344 8813 8818 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 96%937041 IKK complex recruitment mediated by RIP1 7323 330 7314 1147 7322 3551 7321 7099 7334 8517 929 7335 7189 353376 148022 8737 23643 329 11035 6233 7316 7311 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9820960 Respiratory syncytial virus (RSV) attachment and entry 6382 5045 3339 2719 7099 929 1956 221914 2262 9672 23643 2239 4691 3480 2817 1524 5878 5868 5869 6383 10082 6385 375790 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 96%110330 Recognition and association of DNA glycosylase with site containing an affected purine 8331 3013 8337 8334 8335 255626 8341 3018 8342 3017 8347 26277 3014 8348 8345 25913 4350 8340 474382 8970 128312 8338 85236 8349 94239 55766 54386 8370 8290 55247 54145 7013 65057 4968 7014 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-HSA-8847453.3 Synthesis of PIPs in the nucleus 90809 8396 5305 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 96%1480926 O2 CO2 exchange in erythrocytes 6521 606495 51167 3043 51700 759 3040 51706 760 762 358 6005 POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels 3764 6833 9424 3775 10089 3751 10060 3752 3754 3755 3756 131096 56659 3757 3758 3770 338567 9196 27012 27133 10021 27094 3780 3782 3783 3767 26251 27345 3776 3777 51305 3790 348980 57657 170850 3784 10242 3787 3788 7881 83795 23416 9312 93107 23415 169522 54207 50801 3737 3738 56479 3739 610 3781 81033 3736 3778 90134 3779 3750 3748 3749 3785 89822 3741 3786 3742 8514 3743 3744 3745 3746 3747 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 94235 55970 3760 3761 2550 9132 3759 3772 54331 59345 3762 3763 3765 3766 3768 3773 2782 10681 9568 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction 808 3672 10398 5062 7094 302 5829 7169 7168 493829 10174 8291 25802 4629 58498 2983 2982 93408 859 3693 10580 7170 5058 7171 2977 301 10627 217 29895 140465 800 8912 8913 8911 309 4636 103910 7414 4637 8654 4638 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 5782 3320 55914 2064 4893 6464 6654 11140 3265 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 3559 1493 3558 3458 50943 1378 8784 861 4773 865 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 3030 37 3032 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 96%4793954 Defective MOGS causes CDG-2b 7841 DEFECTIVE GALE CAUSES EDG%REACTOME%R-HSA-5609977.5 Defective GALE causes EDG 2582 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation 7314 1147 6500 3551 5604 8517 4790 6416 79155 8945 8454 6233 1326 7316 23291 7311 NEF AND SIGNAL TRANSDUCTION%REACTOME%R-HSA-164944.6 Nef and signal transduction 1794 5879 9844 3932 3055 5062 2534 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins 4853 4854 4855 7057 4851 145173 57188 2591 143662 79695 10417 118430 10418 170689 171019 54437 3955 9510 9037 4582 5199 4583 7058 4584 4585 4586 200958 157869 29954 727897 56667 29071 9507 80070 10585 140766 9508 9509 10071 94025 339366 221981 79875 81794 140453 55901 11041 4588 4589 81792 1605 55624 283463 9719 56999 56913 11093 394263 11173 11096 11095 11174 9215 80731 170690 54507 170692 92949 170691 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 96%397795 G-protein beta:gamma signalling 695 55970 54331 59345 10000 9459 5330 5331 2793 23236 2792 23533 2791 2790 387 207 208 5294 2788 2787 5058 2782 2786 5170 2785 146850 2784 2783 10681 998 51764 94235 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants 2263 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification 8574 22977 124975 2686 95 91703 2687 4257 4258 4259 246181 1800 1577 1544 2678 1576 1553 64174 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events 6915 8997 146 147 148 4893 5588 6654 10235 3265 6195 5594 5595 1908 1906 3358 1910 3357 11343 3356 1133 57105 1131 1128 3269 4935 10800 8503 695 10125 351 5332 2793 2792 2791 2790 2788 2787 2786 301 2785 2784 2783 51764 94235 1839 9630 55970 54331 59345 2642 2641 2767 2769 2776 2782 10681 4295 7200 7201 431704 56413 5031 5032 6003 1909 6004 94233 2798 2797 2796 1907 5028 84432 5029 1902 6375 1241 2693 84109 10874 29933 222545 10887 5724 10886 257313 5731 5737 6288 64407 387129 2911 2358 846 2915 8111 8477 2922 5996 5997 5998 5999 6846 2925 10161 6863 183 185 623 624 4314 10287 56923 6870 8490 2151 23566 2150 2149 2147 6865 2829 2828 6866 6869 353299 885 886 887 2837 347148 9002 57121 338557 5580 3814 156 10911 2840 2846 594857 64106 3827 129521 128674 5578 2867 2865 2864 2863 3710 2862 5330 60675 5331 4922 4923 23236 2869 8620 680 27334 84634 3060 5367 23620 3062 3061 10316 4828 4829 26575 2520 9170 84539 1956 3708 3709 6197 6196 2847 5020 551 5021 552 553 5598 5581 5583 9162 8527 26090 8525 8526 57406 221955 160851 1609 747 1608 1607 1606 139189 7222 7225 115557 5295 5296 57113 5290 7204 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 96%202433 Generation of second messenger molecules 3127 3126 7408 3125 5062 5335 3932 915 7454 916 917 920 9402 51466 3123 4690 3122 5058 3120 3119 3118 55740 5336 3937 3115 7535 27040 3113 9398 2533 3702 5063 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 96%975155 MyD88 dependent cascade initiated on endosome 2353 841 7186 8767 4615 4791 57162 84166 4205 10454 7334 6285 7335 929 6288 11274 7189 64127 353376 6283 148022 3146 51295 257397 51135 9261 4214 23118 9683 9684 6195 1432 10392 28512 79155 57161 79671 5594 177 5595 121457 246330 28511 3656 9097 466 5600 51231 1849 7867 1848 1846 1845 5604 23643 4208 51284 7099 1386 8454 6233 7316 1326 6885 23291 80216 92610 1147 5519 3665 4790 351 4792 5515 6197 6196 4793 5516 5518 8945 3725 3654 5528 7311 5970 7314 6500 3551 8517 5608 5609 6416 5601 5602 5606 5598 2002 5599 7157 9252 54106 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.3 Defective F8 cleavage by thrombin 7450 2157 2147 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9759811 Regulation of CDH11 mRNA translation by microRNAs 23112 26523 57690 192669 192670 27161 27327 4343 1009 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization 5296 4067 5290 5170 5291 6654 2534 9846 7462 6850 5295 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress 1029 1021 1019 SUCCINYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9853506 Succinyl-CoA Biosynthesis 4967 92259 1738 1743 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism 64087 152926 26275 549 56922 3712 594 10295 1629 1738 593 1892 38 SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants 808 10256 817 54518 818 8826 22866 7529 7450 3690 5604 5894 5605 2243 7094 5908 369 283455 408 409 6714 4893 3265 673 4140 5594 5595 2335 3717 2244 1445 2266 5906 7414 815 3674 8844 816 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 96%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 4851 9978 6500 8454 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 96%69091 Polymerase switching 5424 5425 5557 5558 5981 5982 5983 10714 57804 5111 23649 5422 5984 5985 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 8331 8337 10398 8334 8335 3276 861 192670 865 2811 8341 8342 8347 8348 25942 8345 8850 26523 8340 5196 7057 8338 85236 8349 23112 57690 5588 192669 8013 161882 8370 55170 3674 4343 3013 2623 3065 255626 3021 4778 3018 2033 23067 3017 3014 4297 474382 8970 128312 27327 94239 55766 9070 8968 9739 653604 84661 11091 8085 54145 23309 5929 9757 58508 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer 4087 4088 4089 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression 639 7157 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 96%9762292 Regulation of CDH11 function 1500 1499 3728 8728 64403 1495 80332 1006 51129 1009 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 7314 7098 10454 6233 7316 7189 6885 257397 148022 23118 7311 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69186 Lagging Strand Synthesis 5424 6119 5425 5557 5558 6118 5981 5982 5983 10714 2237 57804 5111 3978 23649 6117 5422 1763 5984 5985 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants 1499 5519 1452 139285 2932 5515 324 5516 5518 8312 5525 5526 5527 5528 5529 REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL 4067 867 7525 2889 29760 7409 5295 5296 1399 1398 8503 5290 3055 5291 5293 2534 6850 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 2155 79697 89978 1819 83475 285362 64122 23210 8460 1984 79642 2677 2159 55854 2158 25870 8858 8459 51611 4733 65094 340075 91433 411 23463 79672 6194 410 412 5045 79831 84864 414 2157 415 92715 6228 416 51389 285381 120526 22901 153642 100137047 2621 347527 55239 56648 1725 1802 1801 6132 5627 5624 2147 11338 6157 1938 2107 632 444 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR 4804 4803 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450520 HuR (ELAVL1) binds and stabilizes mRNA 5580 1994 8125 8741 8021 6418 5578 7514 HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation 1984 56648 1725 83475 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 96%9694493 Maturation of protein E 7314 6233 7316 7311 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade 731 27202 710 732 930 721 975 727 733 629 2147 735 717 81494 718 3078 3075 1370 1191 3426 1369 722 725 728 729 1991 966 712 713 714 1378 715 716 3080 4179 719 5627 1361 1380 10877 1604 10878 730 7448 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856828 Clathrin-mediated endocytosis 9341 1601 2017 84251 10980 3482 50813 10920 10618 26119 6453 10987 9146 6456 4952 8027 6455 2060 8674 30011 1213 6457 1211 867 10254 160 161 163 185 1175 1173 3949 154 10093 10092 10094 6869 10097 10096 156 5878 1129 5868 1856 5869 338 3092 6233 7316 10109 8976 10552 1956 9318 7039 408 409 2873 51138 1759 8867 7311 7314 551 554 4738 26052 685 255324 2069 1839 8673 127833 4074 7018 6844 1212 3312 6857 6845 7037 23208 9185 9856 8301 1785 115548 1861 374 9829 55738 5286 915 27348 1950 23149 29924 917 26130 8322 85439 29763 51429 9892 7474 920 50618 22905 2580 382 25977 3267 23396 9026 29988 23048 273 274 58513 54874 157 950 143425 22848 29993 8218 8871 9322 1080 6572 4036 286749 3575 90019 55707 8533 11252 112574 29978 64708 29979 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 96%1614517 Sulfide oxidation to sulfate 1468 6821 7263 23474 58472 100131187 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones 8331 8337 440689 8334 8335 1107 79685 8819 53615 8341 8342 8347 8348 23186 8345 51742 8340 1108 10284 9219 64426 25855 5926 8338 10362 51317 83933 85236 8349 3066 8370 9612 5978 57504 9112 3013 3065 255626 2874 3018 3017 6907 57459 5931 8970 317772 128312 92815 85235 54815 8969 221613 79718 8968 8841 9611 653604 5928 23028 55869 MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 96%9856872 Malate-aspartate shuttle 79751 83733 8402 8604 10165 4190 2806 4191 2805 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9692912 SARS-CoV-1 targets PDZ proteins in cell-cell junction 64398 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 96%177135 Conjugation of benzoate with glycine 10249 219970 92292 116285 389396 348158 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription 23460 65018 4087 4088 3630 4089 2308 10018 2810 56729 356 4852 114907 25942 8850 7295 6648 2309 9314 181 57060 6794 3066 23410 694 1027 1026 5105 7534 10971 2908 5443 7529 3065 6720 10628 604 847 2033 91584 84676 4287 27113 1649 4303 1647 4800 4801 2645 10000 4802 10891 10370 857 2660 3484 7532 901 207 208 23411 1387 2290 2538 5934 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint 5708 5709 5700 5701 5702 5704 5705 5682 5683 63943 51512 5684 5685 5686 3320 22919 5717 891 3326 5718 5719 983 11047 5713 5714 5347 7979 5690 5691 5692 5693 5694 7311 9133 5695 7314 7157 5687 5688 5689 9861 1026 6233 7316 10213 5706 5707 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex 92421 27243 29082 128866 91782 25978 5289 8678 23479 79643 81631 7405 51652 30849 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 96%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) 56606 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%774815 Nucleosome assembly 8331 80152 8607 8337 2491 8334 8335 8341 8342 8347 55320 8348 8345 201254 51773 64946 55355 11339 8340 387103 54069 55839 8338 85236 8349 4869 8370 3013 1060 255626 55166 1058 79019 3018 3017 3014 23421 474382 5931 57082 8970 128312 94239 55766 64105 401541 8467 378708 79172 54145 91687 5928 79682 VIRUS ASSEMBLY AND RELEASE%REACTOME%R-HSA-168268.5 Virus Assembly and Release 821 811 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 96%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 8331 3013 8337 8334 8335 255626 8341 3021 3018 8342 3017 8347 3014 8348 8345 8340 474382 23081 354 3817 8970 128312 8338 85236 8349 10499 94239 55766 8968 5585 653604 8370 54145 367 23028 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839126.4 FGFR2 mutant receptor activation 2963 22916 2962 5434 5435 4686 5436 5437 5438 5439 5430 5431 5432 5433 2263 2254 2252 2251 27006 8074 2249 2248 2247 2246 8823 5440 5441 2255 8817 26281 PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9033241 Peroxisomal protein import 7321 5264 5195 5189 1384 5192 23600 5193 7311 3155 283927 5194 1610 5828 54677 7314 390916 7322 8528 26063 4843 1962 51 122970 8540 5190 11001 3295 5191 54363 30 10901 10005 51179 8239 8310 219743 373156 2053 570 83752 3416 55825 51268 8309 6342 1891 55670 10965 189 196743 4358 54469 26061 8443 3417 847 7323 6233 7316 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%R-HSA-982772.3 Growth hormone receptor signaling 4067 2690 5618 2689 2688 1442 8835 6868 6772 6774 8651 5770 6777 6776 8660 5594 5595 3717 3667 9021 5777 1154 5617 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112307 Transmission across Electrical Synapses 57369 56666 10052 84694 24145 INFECTIOUS DISEASE%REACTOME DATABASE ID RELEASE 96%5663205 Infectious disease 8331 8337 8334 8335 5062 100128731 8341 8342 8347 8348 8345 8340 2475 8338 4791 85236 8349 5879 5034 6185 23476 6184 160 161 2932 746 163 79109 1603 81608 5781 8370 2146 1175 998 1173 5777 3013 3069 55615 255626 5567 84061 5568 6772 3018 3017 3932 7991 64223 201595 10000 3703 8970 128312 3716 1650 8726 8968 7518 7532 7525 207 3981 208 7409 653604 7415 5133 23512 5928 6383 2534 10082 6385 8178 129685 6872 22916 6382 6874 6873 6908 4686 3718 6827 6749 3554 7297 6881 79685 6880 6883 8819 1901 6882 6773 6884 221914 3460 8148 9672 29760 9150 6917 3459 1025 51185 973 51497 11198 23186 2239 974 6875 3454 6878 51742 83860 6877 10280 8812 10284 2342 2959 64426 2958 6879 25855 2339 2957 25920 5926 54457 10362 51317 2961 8189 2960 11051 51224 6921 10978 1479 6924 3339 7936 51692 1478 6923 1477 7469 23283 138474 904 10914 53981 905 51585 2697 29894 55339 2023 2262 2817 2719 60 9883 129401 26007 9688 291 292 293 23225 3836 4927 3159 23165 375790 11168 55706 23636 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 8815 6230 23168 6231 79577 6234 9349 6235 6191 80349 7040 6193 6192 6194 10898 123169 1213 51121 9646 1211 6227 6229 929 6228 54623 11224 7187 9641 200916 6122 6124 6123 6125 7301 2621 25873 140801 558 4360 197259 3921 22924 4736 440400 6130 9076 6133 4061 6132 51234 10461 6135 6134 945 6137 3309 5627 6136 57504 811 91937 11314 6128 9636 3192 6129 9112 6142 6141 6144 6143 6146 6147 142 3304 821 6139 6138 6152 6155 6154 6157 6156 6159 6158 3320 2197 23521 2589 3837 54956 140032 143 3838 2931 3839 5610 63982 56965 5611 83666 6164 79668 6166 84875 203859 6165 54625 6168 6201 6167 8106 5593 6203 6169 6202 116832 57101 6160 6161 2633 402569 3840 3841 3843 5901 6175 5573 9045 338440 6210 6176 6171 6170 6173 51065 6205 6204 6207 6206 2926 6209 6208 6188 6187 6223 9525 51160 6189 55107 55048 6222 89853 6224 11267 6181 51028 6218 155382 6217 137492 27183 93343 7251 51271 861 79720 84313 51510 51534 55129 50636 2194 7284 196527 57719 121601 9785 6430 6432 6431 10250 51362 199746 6427 6426 6429 6428 10189 8683 9775 9295 10921 11338 7307 9397 1452 30835 7448 8907 130340 3105 567 10053 7879 1174 8905 1104 162 1234 55690 5902 164 4836 3688 63916 1794 1793 7322 10454 7334 7335 7189 257397 23191 23118 7534 7533 64135 3442 3065 3441 3440 23586 5499 80143 84282 57506 3452 3451 3449 3448 3446 3445 3444 5500 3443 7706 6733 6732 4691 3480 1524 5878 5868 5869 5747 857 4650 7410 26986 4690 3615 3614 7852 10451 8829 5576 6093 3183 71 7431 9475 27316 3326 79869 8813 8818 5045 1977 5230 54344 1981 7113 59272 26762 57521 2002 1839 22987 112755 127833 9899 6843 9900 6844 375 6616 3312 6857 6804 6667 51128 9871 9632 1312 10427 22937 5289 10802 10484 30849 54106 92421 27243 3553 128866 834 10015 837 3570 83737 79643 51652 8737 11035 3606 7318 7317 79792 10533 29082 91782 3552 25978 2147 55236 476 477 478 57674 53822 89122 3710 53826 53828 480 481 482 483 486 5348 5349 23352 815 816 817 818 10768 3708 3709 5566 7295 9246 5609 6416 1994 9817 9039 3569 8065 3456 79876 5599 1191 51191 722 725 7428 5335 598 1938 1915 10207 6868 92359 64398 50628 6632 6628 79760 54960 6634 6633 10811 6636 1535 6635 10458 6637 25929 79833 6607 55845 8487 11218 440689 721 10787 8936 718 10152 124056 8678 23479 81631 7405 3071 10163 2984 27035 10006 4843 9844 3055 926 10965 11045 4072 5824 10421 55588 10093 91662 10092 22863 10095 27072 4210 285755 10094 80306 5025 57794 10097 317649 10096 22826 1855 22827 11282 57105 1052 7841 111 4318 29801 10810 6993 25921 112 11100 253832 113 23339 114 51201 10262 55741 115 54883 11320 2268 51125 90701 1857 11325 4247 1856 10236 7454 51304 55749 7456 4249 10610 64225 2678 4131 5027 6483 8974 64174 6482 23765 147179 6484 23524 6487 10910 54431 1511 4245 4124 10450 136 57703 6480 4907 684 2687 25834 689 4620 23193 11311 256435 2209 10465 79844 346562 5479 5575 2530 27090 54463 4641 53938 11253 1800 28972 10800 5589 5033 51114 2214 64601 2212 24148 4651 9868 29108 23020 644150 114548 85313 9879 26999 9410 953 9412 5577 9416 5336 10181 4644 5613 9685 51340 79651 957 23478 10769 719 5093 10109 9332 8976 5094 3586 196883 51593 4627 57461 6850 84844 2771 65082 2770 695 1982 1993 10552 27238 2781 400569 9051 8175 2773 283208 107 51726 108 51729 109 55090 51517 7097 7096 2634 23097 80273 112744 5987 51503 23601 55696 10992 10525 10527 5725 3978 10523 6837 4670 3654 84818 4666 10951 3107 3106 988 10134 6627 6629 220988 3134 3133 9908 81857 23450 23451 56949 5546 6638 10146 219541 3135 10594 6421 25820 550 115361 54797 10332 10333 6441 5356 3178 80824 79849 3181 3188 3187 3185 3184 3676 55666 9716 5119 10313 3191 928 3190 7555 57617 51639 10628 4057 8896 1024 163351 51645 6238 8672 23389 85437 9532 7353 10084 10291 9789 10294 23367 8449 11151 55823 11123 2923 10283 8241 25777 23350 10286 10285 9343 56259 26276 23327 9111 10945 10946 10949 10907 9360 60559 1654 27339 1665 4939 84991 3605 2521 83443 10025 892 3276 10001 8767 29079 3066 64127 10392 9612 9862 3656 54815 203068 84246 9443 9861 9441 9442 6233 7316 10213 9440 6885 5706 5707 5708 51586 5709 1147 9439 5700 5701 10155 5702 5704 1956 5705 4790 5682 5683 4792 5684 4793 2810 5685 5686 5717 5718 5719 8945 11047 5713 5714 9219 7979 5690 5691 9477 5692 7296 5693 5694 112950 7311 5970 5695 7314 6500 3551 5687 5688 8517 5689 7341 1514 55763 8729 2908 7329 2874 9282 1107 9382 1108 9146 6456 4233 8027 6455 2060 79872 1500 1499 30011 4869 999 6457 867 10254 6714 6654 1432 1398 5594 5595 10971 5978 22938 7529 5604 5605 2033 3043 23643 3162 3040 6907 57459 335 7514 51003 79718 54464 7099 4780 8841 9611 1387 5469 23028 2288 6886 2280 808 1655 5478 7531 10728 3725 9978 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 94235 55970 5371 54331 59345 9968 9969 7474 8324 29959 2782 25 2778 10681 8452 4088 4089 53615 2237 1616 1974 1973 5925 6232 90390 8655 4904 348995 57122 317772 51143 92815 55746 85235 8969 221613 23279 7098 79023 51284 51311 4153 6396 1781 1780 712 1778 716 5648 57551 3717 5905 7520 1783 1660 2547 5501 115004 5903 340061 3665 140735 79902 51606 7082 5440 5441 8732 4331 8731 1022 2071 6829 2966 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 1460 1459 29110 1457 3661 5931 81030 917 4067 920 4751 253260 5295 5170 58505 940 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME DATABASE ID RELEASE 96%3656237 Defective EXT2 causes exostoses 2 6382 3339 2719 221914 2262 9672 2239 2817 6383 10082 6385 2132 375790 2131 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 1997 861 865 3562 3977 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins 240 239 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 283 23405 60528 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%156584 Cytosolic sulfonation of small molecules 84836 6819 27284 445329 27233 6799 50512 6822 8460 54928 8459 6783 10380 391365 25830 6818 6817 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex 22916 4686 6827 6749 4298 6830 27125 55840 4300 85403 9150 55677 6917 1025 51497 11198 8812 23168 79577 25920 80349 51224 6921 123169 6924 7936 9646 6923 7469 904 905 54623 5440 5441 4331 1022 2071 6829 2966 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 8178 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 96%1300642 Sperm Motility And Taxes 378807 347732 117155 79820 157855 257062 117144 84329 57828 RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013419 RHOT2 GTPase cycle 55669 66008 89941 5910 9927 22906 80179 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%8875878 MET promotes cell motility 3910 3911 3912 3673 3675 5908 64759 3688 84951 2549 85440 4233 5747 5879 6714 3082 2889 1399 1398 3913 3914 3915 3918 284217 10319 5906 3908 3909 SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation 23636 9972 9631 7175 11097 23511 1107 8086 8021 23314 53371 8480 10762 6790 25942 7508 9189 197370 493861 9994 115426 57591 7690 4791 79677 1789 56160 1788 54780 1786 4869 10521 6672 205564 6304 10055 10054 51602 286053 3066 9641 25950 23137 4152 59343 29843 6294 7153 1616 7155 7150 8370 9612 9112 3065 142 10210 165918 4286 7158 5893 2033 348995 9126 57122 5610 8648 7703 10891 55746 10499 9656 23279 79023 7518 8204 6396 51564 59348 1387 7022 1069 10735 7021 3622 23512 6996 5905 23468 1655 5903 3183 332 55143 10155 8924 10274 3619 4792 8535 5987 9212 8243 79902 5885 648 5970 6015 4193 83746 1912 8517 1911 6670 3090 668 7341 80012 7068 84733 5241 7376 6256 7421 5465 8554 2099 7181 6095 6045 367 4929 2908 51588 6612 9759 5468 7329 1029 6613 4306 2516 5914 10401 7486 3190 5371 672 57332 7428 28996 5111 641 6117 7157 1487 9883 129401 9688 23225 4927 23165 11315 55706 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 96%5654708 Downstream signaling of activated FGFR3 4893 6654 2254 3265 5781 5295 8074 2249 2247 10817 5290 2246 5335 8823 2549 10818 8817 26281 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 96%9008059 Interleukin-37 signaling 5782 5775 4088 834 5781 6774 5780 5771 5783 5784 29110 26469 25930 84867 26095 8809 59307 27178 5777 10068 5778 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME DATABASE ID RELEASE 96%442729 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde 808 818 814 3838 84254 10645 816 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade 2353 8651 841 7186 8767 4615 4791 57162 84166 4205 10454 7334 6285 7335 929 6288 11274 7189 64127 6283 3146 51295 257397 51135 9261 4214 23118 9683 9684 6195 1432 6279 10392 6280 28512 79155 57161 79671 5594 177 5595 121457 246330 28511 59307 3656 9097 466 5600 51231 114609 1849 7867 948 1848 11213 1846 6271 1845 5604 23643 4208 7099 1386 8454 6233 7316 1326 6885 2244 2266 23291 80216 92610 695 1147 5519 2243 4790 7097 7096 351 4792 5515 6197 6196 4793 5516 5518 8945 3725 3654 5528 7311 5970 7314 6500 3551 8517 5608 5609 6416 5601 5602 5606 10333 5598 2002 5599 7157 9252 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease 9652 10767 115024 28960 5393 11340 22894 23016 23404 51010 54512 6499 51013 56915 118460 80349 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 96%3214841 PKMTs methylate histone lysines 63976 7468 64754 4790 84444 84787 83852 55729 121536 56979 79918 84193 23067 64324 2122 79813 6839 4297 55870 80854 51111 79723 9869 5931 54904 29072 4791 387893 5970 9070 8726 8968 9739 10919 653604 84661 8370 11091 8085 23512 5928 2146 5929 56950 9757 58508 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-HSA-1614558.10 Degradation of cysteine and homocysteine 51380 2326 1036 6821 2806 23474 339896 1491 1468 4357 84890 7263 25828 58472 100131187 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 96%1237112 Methionine salvage pathway 55256 4507 58478 84245 2805 51074 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME%R-HSA-9711123.6 Cellular response to chemical stress 1351 1350 1349 1347 1346 1345 81631 653361 5034 125965 2932 64839 213 5753 2168 23657 3417 5563 6774 96764 2033 3043 3162 613227 3040 571 6907 80205 10000 8648 7975 10499 10498 79718 6604 4780 4697 8841 207 208 9611 50507 7415 1387 114548 23054 5469 85441 2938 5052 7001 6648 4851 9978 4512 4513 4514 55666 8878 10628 847 6888 84701 7353 6667 7086 5226 25828 8452 341947 25942 54205 5584 6502 1026 9612 4363 9377 5580 475 6347 493869 140809 79400 4199 10072 30001 81502 83667 4097 10061 257202 9167 79594 1728 9588 2940 10935 27244 26043 2950 644 645 84181 9451 55620 6647 2729 9861 6649 8454 2730 2539 6233 8714 7316 318 2880 2878 10213 2876 10587 5706 2882 9973 5707 6737 538 343 5708 468 5709 5700 5701 5702 5704 139285 5705 4790 5682 5683 5684 5685 5686 5717 5718 5719 8945 11047 7295 5713 5714 7979 5690 5691 7296 5692 5693 5694 7311 5970 5695 7314 6500 5687 5688 5689 3163 6256 5465 9429 9817 1029 2877 672 1460 1459 1457 4609 374 596 5154 1950 598 79728 1327 1329 1340 1536 1535 1337 4688 1339 4689 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 96%9683686 Maturation of spike protein 7841 4245 23193 821 5589 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 2254 2252 5781 2251 27006 5295 8074 2249 2248 2247 5290 2246 8823 2549 2255 10818 8817 26281 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 96%187706 Signalling to p38 via RIT and RIN 4803 6014 6016 4914 673 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis 9043 1013 1496 4207 6925 4617 4618 663 4917 1002 4654 4656 4756 6929 1000 1499 4208 4205 4209 6938 5608 50937 1432 25 1495 6300 998 5600 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%199920 CREB phosphorylation 6195 9252 6197 9261 6196 466 DEVELOPMENTAL CELL LINEAGES%REACTOME%R-HSA-9734767.4 Developmental Cell Lineages 3910 3911 3912 7039 2252 2249 2247 3913 3914 374 3915 2335 2255 3918 1950 284217 10319 3908 3909 7448 5617 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 137872 728294 79944 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 8331 8337 8334 3276 8335 84333 192670 27161 83737 7122 8341 8342 8347 8348 25942 8345 26523 8340 5196 8338 85236 8349 23112 1021 6714 57690 595 5588 192669 894 200845 896 5781 86 8013 3562 7161 3559 8370 3558 1378 6595 55170 6597 6599 6598 4343 3013 3065 255626 26053 8784 6601 6603 5275 6602 6605 3021 8289 3018 2033 3017 55193 3014 474382 8312 8970 128312 27327 55766 6604 8968 10138 1437 653604 1387 84661 23429 11091 8085 9861 6233 7316 5579 5929 4773 10213 5706 6886 5707 5708 5709 10398 5700 5701 5702 5704 1998 5705 1997 640 5682 861 5683 5079 865 5684 2811 8535 5685 5686 5717 5718 5719 6929 8850 11047 5713 5714 7979 5690 5691 5692 7057 5693 4004 648 5694 7311 5695 4005 6015 7314 5687 5688 8861 1912 1911 5689 6938 80012 1514 84733 161882 100506658 1513 7082 196528 2099 1515 6045 4331 57492 1022 9021 2625 3958 3674 2624 2623 23466 6688 84870 5371 57332 4778 902 23067 3458 4297 28996 1460 1459 1457 10413 3977 57678 122809 94239 9070 50943 9739 51412 1493 25 54145 23309 4602 9757 58508 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%421270 Cell-cell junction organization 8331 8337 8334 8335 100128731 192670 27161 8341 8342 8347 8348 8345 50649 26523 8340 8338 51129 2060 79872 85236 1500 1499 8349 1793 5879 6185 999 23112 6184 6714 57690 192669 746 1603 6591 26508 8370 9844 5594 5595 2146 998 4343 3013 3065 255626 6774 3021 3018 6663 3017 7841 3014 474382 90701 3703 8970 128312 27327 3716 55766 1650 8726 8968 23193 7410 28972 5589 23411 653604 2294 56978 8728 64403 23512 1495 27319 5928 23028 23478 80332 1006 3224 3609 6615 1009 7764 7297 6929 5045 5046 288 6938 11171 55810 687 93986 9789 1785 6667 29954 10585 60559 283 3570 7122 329 3170 9314 5584 331 54971 3066 9076 5925 6597 117581 57531 821 8289 387893 84231 1520 1508 9861 6233 7316 3717 10213 5706 7020 7414 5707 5708 5709 1013 5700 127544 5701 5702 5704 5705 4790 1002 5682 5683 5684 5685 9069 5686 81607 5717 5817 5718 27085 5719 5818 5819 11047 57863 5713 137075 5714 94234 7979 24146 5690 9073 5691 9071 5692 9074 5693 9075 5694 84552 7311 23705 5970 7291 283106 5695 9080 7314 53842 1010 1008 5687 4193 1007 5688 1005 1004 5689 1366 1003 1365 1364 1001 1016 1514 1015 1012 51208 3572 7490 49861 10399 54737 221935 348262 23562 253559 149461 26285 80149 5315 7750 10009 3569 84612 60436 54549 7088 25945 9159 28513 5010 9855 10686 7074 1460 1459 1457 9839 4609 5931 1000 94239 6935 4613 50848 23396 10207 92359 64398 56288 50855 1488 1487 3728 54145 58505 9743 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex 7314 10454 7099 929 7189 353376 257397 148022 23118 23643 6233 7316 6885 3656 7311 INTERFERON SIGNALING%REACTOME%R-HSA-913531.6 Interferon Signaling 4261 10581 9830 7412 23650 4502 3105 10107 2635 567 4938 5229 3608 10346 10437 7324 388646 8678 4940 25939 4281 2537 103 8638 201254 8519 983 1965 5696 8894 4869 1968 7334 5781 3123 3122 3120 3119 3118 5594 5595 3115 3113 5777 3127 64135 3442 3126 3441 3125 3440 23586 57506 3452 3451 6772 3449 3448 6774 3446 3445 317649 3444 5770 3443 7706 54920 2316 5300 3716 684 2209 4690 5292 2289 3609 1982 71 7297 6773 2634 3460 3459 960 3454 2342 2339 3107 3106 5045 3134 3133 3135 1977 25820 115361 1981 4684 5371 163351 3312 8672 60 3458 7157 4939 8877 9883 129401 9688 23225 3836 4927 23165 2176 55706 23636 9972 9631 7175 11097 23511 834 8086 8021 53371 8480 10762 8651 4092 6059 3660 7318 6672 5724 11274 3663 4734 5771 1974 1973 3309 9636 3304 4904 3662 348995 3837 5580 3838 3839 5610 57122 5611 55746 23279 79023 2633 402569 3840 3841 6396 378708 5495 9451 6233 7316 3717 1660 815 816 6737 817 818 5903 1147 5519 5894 3665 5515 5516 2810 5518 79902 9246 5525 7311 7314 3551 8517 5608 7341 8554 9021 7329 9775 3456 24138 81603 79097 4600 51191 10410 11074 2317 55223 53840 91543 3430 5335 201626 3306 3305 3661 3664 3669 8575 3429 199990 6895 55120 10612 3437 55128 3434 3433 51447 91442 6041 1958 54739 10964 57697 117854 23321 80128 6622 3659 51127 10379 22926 9470 80233 7726 85363 2175 3383 10475 80263 2188 2187 3394 2178 4599 115362 23087 2189 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 96%2555396 Mitotic Metaphase and Anaphase 51529 7321 8881 64682 25906 11065 1104 8697 7324 10393 29945 27338 119504 29882 891 246184 7443 983 9798 996 51434 22933 51433 221496 200014 5347 2010 9700 260334 6683 347688 23141 23592 5520 7514 26271 4001 113457 7280 10376 80086 51807 10381 10383 10382 112714 7846 84790 84617 347733 7277 7278 81027 79861 9883 129401 9688 23165 55706 92421 23636 9631 27243 128866 23511 53371 8815 79643 51652 29082 91782 25978 54908 6232 8655 25909 8379 9183 23047 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 113130 348995 348235 3837 9126 5048 23421 57122 220134 57082 57405 147841 51143 6249 55746 4085 9133 64105 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 5901 1781 23122 23244 1780 79172 1778 81930 10735 9861 55920 84643 6233 3796 7316 9793 91687 57551 79682 10213 5905 5706 1783 5501 5707 83540 5708 80152 5709 5903 2491 5519 5700 332 5701 55143 5702 27183 23063 5704 699 5705 11243 10274 5682 140735 5683 3619 5515 11004 5684 5516 5518 5685 9212 5686 25936 5717 8243 5718 11130 5719 64946 79980 11047 10726 5713 79902 5714 5885 5525 7979 5526 5690 55839 5691 5527 5692 5528 5693 5529 5694 7311 5695 7314 5687 5688 5689 7341 3930 7329 3842 9232 TBC RABGAPS%REACTOME DATABASE ID RELEASE 96%8854214 TBC RABGAPs 7879 51560 81631 5870 8766 5878 5868 5869 374403 11021 9363 84958 23062 57465 23163 51762 79735 27342 382 83874 83452 4943 7248 11345 8408 9135 23637 10133 729873 338382 64786 125058 9230 54662 26088 26000 7249 55357 51256 57533 5867 128637 11337 4218 ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 96%1482788 Acyl chain remodelling of PC 10162 123745 79887 5319 255189 50640 50487 22925 151056 54947 64600 100137049 254531 79888 30814 5321 8399 5320 5322 26279 283748 81579 8398 129642 255043 8605 11145 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME%R-HSA-9022534.2 Loss of MECP2 binding ability to 5hmC-DNA MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 96%9636667 Manipulation of host energy metabolism 5230 2023 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 96%9627069 Regulation of the apoptosome activity 331 317 842 54205 5594 22900 5595 57099 55075 56616 51074 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling 841 356 355 843 8772 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation 10621 5434 6908 5435 5437 6621 55290 6619 7702 6618 10302 6617 51082 84265 55703 112495 11128 51728 9533 9330 27297 661 2976 5440 10623 5441 2975 2972 2971 171568 55814 5451 9328 9329 55718 10622 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 96%2428924 IGF1R signaling cascade 117145 8471 3481 3479 3480 2549 5140 9965 4893 57761 6654 5289 2254 3265 2252 5781 2251 208 27006 8074 5295 2249 5296 2248 2247 2246 5290 152831 5170 8823 5291 8660 30849 2264 2255 2323 2322 54106 10818 9846 3667 8817 26281 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 96%9819196 Zygotic genome activation (ZGA) 151871 7004 284355 7157 2033 1387 23318 390245 100288687 201516 79670 503627 503835 10413 55211 342900 100033411 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390650 Histamine receptors 3274 3269 11255 59340 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME DATABASE ID RELEASE 96%2033515 t(4;14) translocations of FGFR3 2261 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME%R-HSA-5362768.4 Hh mutants are degraded by ERAD 6400 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 10956 7311 5695 7314 84447 5687 5688 5689 7415 27248 9861 6233 7316 10213 6469 5706 51009 5707 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 96%429947 Deadenylation of mRNA 9125 25904 9775 55571 85456 5073 246175 23318 79670 57472 9337 10605 9924 255967 1975 26986 23019 1977 4850 29883 1981 1974 4848 1973 4849 SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000471 Scavenging by Class B Receptors 948 6280 5052 922 6288 284297 335 3146 338 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME%R-HSA-453279.6 Mitotic G1 phase and G1 S transition 54107 84515 5000 5001 23594 23595 4998 891 4999 983 23649 5422 5557 5558 7027 1021 1019 595 1017 894 896 29935 1871 10926 898 81620 1870 6502 91768 7153 7465 51053 286826 9134 55388 4149 1028 132660 1027 1026 91750 1163 5753 7029 1869 55957 5925 3065 1876 1875 1874 5520 10000 8317 1859 7298 28227 7083 207 26271 208 1719 9861 8454 6233 7316 5928 3717 10213 5706 5707 5708 5709 5519 5700 5701 5702 5704 5705 5682 5683 5515 5684 5516 993 5685 5518 5686 5717 5718 5719 11047 5713 4172 5714 4173 7979 4174 5690 4175 5691 4176 5692 5693 5694 8318 7311 4171 5695 7314 6500 890 5687 5688 5689 4331 1022 1032 1031 1030 1029 8900 56655 902 990 5111 4609 6117 4067 6119 6118 5426 5427 6241 25 5933 5934 4605 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux 344 346 2874 192670 27161 2033 64241 64240 26523 348 6907 8648 27327 9619 10062 79718 23112 19 57690 1071 192669 8841 9682 9611 80820 221656 7376 347 6256 10123 55818 9612 23028 6257 341 4343 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%500792 GPCR ligand binding 727 718 6915 146 147 148 9287 3363 3362 3361 3360 59340 153 2652 154 155 3358 3357 3356 1133 3355 1816 83551 1815 1814 1813 1812 134864 319100 134860 57105 9038 1132 3354 1131 3352 3274 3351 3350 1129 1128 3269 11255 4935 136 10800 719 1901 4986 4988 2550 6750 9568 6010 6288 6753 6347 2847 611 1234 4852 1908 1906 5443 4157 1910 4161 4160 4159 1524 7252 1081 6387 51083 7852 729230 1230 10663 1240 56670 338398 1238 1237 1236 1235 1233 1232 170589 4985 4987 5956 3792 5729 27198 27199 5726 5739 2587 5732 4886 351 5733 5734 4887 10850 4889 2359 1269 2357 1268 259289 2492 259287 259286 259285 3579 3577 2488 56477 5995 4543 4544 259294 259293 7484 259292 7483 259290 30817 5741 259296 2793 259295 2792 353164 2791 5660 2790 6751 5540 7480 6752 9340 5539 7482 116512 7481 2788 338442 2787 54886 643 796 2786 6755 80326 6754 301 8811 797 2785 151306 163404 116 2784 8843 5697 2740 256933 117 79948 799 2783 7504 54429 6469 80835 51764 80834 94235 3375 10692 1394 9934 1393 5473 54361 4142 1392 8862 55970 51052 9718 113091 79924 4283 10266 6346 5744 4158 5745 5368 10268 10563 5746 6351 10267 6352 6354 50846 90226 6357 2692 6356 2691 6348 6608 6349 5030 133 54331 6361 51384 6364 114131 6363 53829 59345 6366 2642 6367 2641 7855 6360 7976 1903 976 6373 6372 8321 6374 7473 6376 8322 6370 7472 89780 134 135 7475 5173 7474 8325 5179 7433 9890 6344 64748 150 7477 140 151 8326 51554 152 7476 58191 7432 8698 6343 7253 8323 2919 7479 2918 8324 2917 7434 2916 7478 2914 8643 53637 2913 2782 7471 2912 3549 2921 2920 84658 221391 2778 8484 2535 2015 11251 2696 23596 2695 186 7349 187 10681 83756 11211 165140 1604 50831 5727 50833 10203 50832 2826 50835 50834 50837 50836 50839 50838 2834 2833 4295 2832 7200 2831 7201 122876 50840 56413 1880 5031 57007 5032 283869 2841 1909 57486 2853 94233 2852 2798 10803 2797 2859 2796 50865 1907 1889 5028 5196 2861 84432 9034 5029 64805 1902 9283 6375 3972 1241 3973 2693 9290 84109 9294 10874 1325 29933 2532 222545 3627 10887 5724 10886 257313 5731 5737 387129 2911 2358 846 2915 8111 8477 2922 6846 2925 10161 6863 183 185 623 624 56923 6870 2151 23566 2150 2149 2147 6865 2829 2828 6866 6869 885 886 887 2837 347148 9002 57121 338557 3814 10911 2840 2846 594857 64106 3827 129521 128674 2867 2865 2864 2863 2862 60675 4922 4923 8620 680 27334 84634 3060 5367 23620 3062 3061 10316 4828 4829 9170 84539 5020 551 5021 552 553 554 27202 3576 728 51289 3640 10022 122042 117579 6019 339403 59350 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%205043 NRIF signals cell death from the nucleus 4804 8878 7314 5599 7189 5663 5664 55851 83464 23385 51107 4803 6233 23421 7316 7311 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764274 Regulation of Expression and Function of Type I Classical Cadherins 8331 8337 8334 8335 100128731 192670 27161 8341 8342 8347 8348 8345 3170 26523 8340 9314 8338 2060 79872 1500 85236 1499 8349 54971 999 6185 23112 6184 6714 57690 3066 192669 746 1603 6591 8370 5594 5595 5925 2146 6597 4343 3013 3065 255626 117581 821 3021 8289 3018 3017 7841 3014 474382 90701 3703 8970 128312 27327 387893 55766 1650 8726 8968 1520 23193 1508 28972 5589 23411 653604 9861 6233 23512 7316 1495 5928 23028 23478 10213 5706 7020 7414 6615 5707 7764 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 27085 5719 6929 11047 5713 5714 94234 7979 5690 5691 5692 5693 5694 7311 7291 283106 5695 7314 5045 5046 5687 4193 5688 288 5689 6938 1514 7490 10399 54737 348262 5315 7750 10009 60436 7088 9159 11171 55810 687 93986 1460 1459 9789 1785 1457 6667 9839 4609 5931 29954 10585 94239 6935 4613 23396 60559 1488 1487 3728 54145 58505 9743 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME%R-HSA-9931295.1 PD-L1(CD274) glycosylation and translocation to plasma membrane 3716 6185 1650 6184 10331 84061 29126 746 142678 100128731 1603 80380 5133 7991 58505 201595 3703 G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation 5443 5173 9630 2769 55970 2793 2792 2791 2790 2776 2788 2787 2782 2786 54331 2785 59345 2784 2783 10681 2767 51764 4988 94235 HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.7 Hyaluronan degradation 11261 3161 8692 55576 26503 2990 23553 3373 960 8372 57214 3074 3073 6677 10894 6548 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702632 sunitinib-resistant FLT3 mutants 2322 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022928 HS-GAG biosynthesis 26035 6382 2719 64579 9957 221914 9955 9672 64711 9956 8509 222537 2239 266722 2132 2131 3340 3339 2262 9953 9951 2137 2135 11046 9394 2817 9348 9653 90161 6383 10082 6385 375790 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 79947 116150 KILLING MECHANISMS%REACTOME%R-HSA-9664420.3 Killing mechanisms 1855 7474 5879 10811 1535 27035 5599 1857 3725 1856 8324 124056 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%5654688 SHC-mediated cascade:FGFR1 4893 6654 2254 3265 2251 27006 8074 2249 2248 2247 2246 2255 26281 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation 9341 3105 567 5698 5699 653361 4615 5696 5720 55176 5721 9902 6890 6892 6891 929 29927 6810 23480 50489 3146 10952 4360 6279 6280 811 114609 948 6271 23643 3685 1520 2209 7099 9861 6233 7316 10213 2244 2266 5706 5707 5708 5709 695 1147 5700 5701 5702 5704 5705 2243 5682 7097 5683 7096 5684 5685 5686 5717 5718 5719 11047 5713 5714 9554 7979 5690 5691 5692 5693 3107 5694 3106 7311 5695 7314 3134 3551 3133 5687 5688 8517 5689 1514 3135 3693 4012 1515 10333 8673 2923 8773 1536 1535 4688 4689 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME%R-HSA-5619035.3 Defective SLC17A5 causes Salla disease (SD) and ISSD 26503 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound 5756 3781 57053 3778 3779 5962 4478 6709 6711 129446 440699 25861 9381 161497 27445 124590 830 51168 832 11344 64072 8927 4647 9478 53904 776 494513 246213 9750 51475 259236 6855 65217 829 23136 339768 117532 117531 7430 25794 283310 643226 340990 286262 375611 4354 10518 5357 53405 10083 64787 222662 6844 83715 9132 6616 389207 6804 2059 140469 2934 2036 5864 80331 55584 6853 4641 9254 783 8573 490 4627 SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 7077 7076 3070 5914 3624 4088 3623 6925 4089 4617 4618 4654 192670 4656 27161 408 409 2033 6929 26523 6667 27327 7040 23112 4613 7046 7048 57690 6938 192669 5663 5664 55851 83464 23385 6256 51107 2247 7049 7042 83855 10755 4323 92 4325 4343 PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964208 Phenylalanine metabolism 5053 883 259307 5860 5092 80150 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 96%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) 6513 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs 4087 4088 3690 4089 9040 5499 7043 4052 4053 4054 25805 64750 23645 5500 3696 11171 4092 56937 9958 8425 3694 3688 9110 51377 8516 3685 10273 7040 7514 7311 7314 57154 5045 867 7046 7048 23327 3693 4738 6233 7316 7049 7042 2280 5501 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling 7314 9542 10193 6233 2064 7316 9101 10000 3084 207 208 7311 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963888 Chylomicron assembly 344 345 5034 336 337 348 4547 51128 335 338 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 130589 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression 8331 8337 8334 6908 8335 79685 8819 8341 8342 8347 8348 25942 8345 51742 8340 10284 64426 8338 1789 85236 1786 8349 3066 8370 5440 5441 4331 1022 2071 2966 2965 3013 2068 3065 5434 5435 8932 255626 5437 2968 2967 404672 3021 3018 902 3017 3014 474382 221830 29115 8970 7343 128312 25885 79595 9014 9015 94239 9013 55766 64425 7270 79101 8968 10849 11176 8467 30834 84172 51082 653604 9533 54145 23309 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 96%2214320 Anchoring fibril formation 1294 3914 7093 3918 7092 649 3909 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717329 lorlatinib-resistant ALK mutants 238 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME DATABASE ID RELEASE 96%9845621 Defective VWF cleavage by ADAMTS13 variant 11093 7450 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a 6484 6487 2589 6480 256435 27090 10610 6483 6482 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes 7157 1026 25946 57060 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress 817 23636 91582 5903 818 9972 9529 9631 10049 7175 3308 11097 23511 8086 8021 53371 7531 8480 10762 10728 3326 79902 2475 2932 9261 5594 3313 5595 3309 57521 84335 3304 472 3312 3320 2033 9532 348995 3306 64223 3305 57122 6117 55746 6119 1915 6118 23279 79023 6396 10808 3281 10013 27000 23411 26353 259217 7415 1410 1387 3297 116835 9883 129401 7266 9688 51182 573 3337 6767 23225 51501 57805 4927 2288 9531 22824 23165 6782 815 9530 816 55706 3310 545 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER 85015 6613 2068 9557 10401 142 2968 2967 10038 404672 2067 5886 902 5887 1643 8451 7507 8450 7508 1642 6117 7311 6119 9978 7314 7336 6118 7334 7341 8554 1069 6233 7316 4331 1022 2071 6612 2073 2072 2966 2965 54778 7329 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death 841 8737 23643 11035 7099 929 353376 148022 8772 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163358.7 PKA-mediated phosphorylation of key metabolic factors 5567 51085 5568 5566 5207 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) 6531 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 96%1169408 ISG15 antiviral mechanism 23636 1982 5903 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 7324 8678 9246 79902 7318 7311 7314 7334 11274 1977 25820 4734 1981 1974 1973 5595 9636 9775 23586 6772 4600 51191 8672 317649 2317 7706 348995 3837 5335 3838 3839 5610 3661 57122 5300 55746 3716 3434 23279 79023 402569 3840 3841 6396 5495 9470 9883 129401 9688 6233 7316 23225 3836 4927 4599 23165 55706 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 96%171007 p38MAPK events 1432 7867 5900 5898 5899 5603 6300 4893 3265 9261 5600 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) 6844 DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system 710 3818 2161 2147 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 96%156590 Glutathione conjugation 124975 2686 4257 79094 4258 26873 4259 2098 653689 27306 2941 79017 55748 2949 2948 2947 2946 221357 2954 2953 2952 494143 119391 9446 2678 10327 2687 2940 2950 373156 2937 2944 2729 2730 2939 2938 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 96%9956529 ASL variants cause argininosuccinate aciduria 435 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73864 RNA Polymerase I Transcription 8331 8337 8334 6908 8335 1107 53615 8341 11335 8342 8347 8348 8345 8850 8340 1108 2074 9219 54700 8338 85236 8349 3066 10919 8370 5440 5441 5595 4331 1022 57504 2071 9112 2966 2965 3013 2068 3065 5434 5435 8932 255626 5437 2968 2967 404672 3021 3018 902 3017 3014 474382 57459 5931 221830 8970 7343 128312 25885 54815 9014 2648 9015 94239 9013 55766 64425 7270 79101 8968 10849 30834 84172 51082 653604 9533 54145 5928 284119 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly 27158 51750 5424 10101 2068 51647 83990 22 64210 4682 9391 64428 57019 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions 11160 2260 9530 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation 2249 2247 2261 2246 8823 2254 8817 26281 8074 GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation 2770 55970 2774 2773 107 108 3760 109 3761 2550 3759 3772 111 54331 112 113 114 59345 115 3762 3763 3765 3766 3768 2793 2792 346562 2791 3773 2790 2788 2787 2782 2786 2785 2784 2783 10681 51764 196883 94235 9568 2771 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%8868773 rRNA processing in the nucleus and cytosol 5393 11340 22894 23016 23404 51010 54512 51013 56915 118460 4691 22803 51504 10528 6230 6231 6234 9349 6235 6191 6193 6192 6194 51121 6227 6229 6228 51602 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 1453 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 6222 6224 6181 6218 6217 7311 9188 23160 79897 92856 54913 5394 28987 8780 51096 5822 115939 114049 81875 57647 55226 90459 10199 8568 22984 11056 705 57418 10885 10171 23246 84916 27043 27042 23481 55127 84128 51202 55131 9790 81887 55813 27292 56902 84946 117246 83732 88745 55272 10969 10607 84135 51118 10813 55720 11102 11103 65083 1736 25879 54881 26168 27340 27341 79159 55623 51388 55505 9136 55759 134430 79707 1454 79050 4809 54555 4839 54433 26354 8602 9277 55651 2091 25926 10799 10557 10436 10438 55781 10556 23517 57050 51077 9724 10200 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 96%114604 GPVI-mediated activation cascade 388 3932 51266 4067 5879 23533 7410 5590 387 5781 5294 7409 5295 5296 5880 8503 5290 10451 5170 5291 146850 5336 3937 80739 27040 2207 2534 998 51206 391 5777 10630 6850 INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 96%6783783 Interleukin-10 signaling 3557 5743 3976 7076 3569 2208 7132 3553 7133 7850 3593 1435 3554 3592 3576 7297 3588 3587 6351 1234 6352 6774 6348 6349 6364 2357 6363 3606 6367 6347 3716 3627 5724 3552 1437 2919 2920 729230 3383 1230 941 942 3586 7124 1440 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%1222499 Latent infection - Other responses of Mtb to phagocytosis 4057 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 96%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 9978 7314 6500 5687 5688 2932 5689 4780 9861 8454 6233 7316 10213 5706 5707 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 96%76002 Platelet activation, signaling and aggregation 5099 388 5267 350 94121 8407 11069 10411 12 6915 14 5155 1 51097 23052 9749 135228 2768 54495 813 5175 7114 3671 66005 6814 10672 6813 7123 29106 83706 5879 10184 51571 967 9564 6714 5874 3699 7273 5588 54863 6654 2 81 10235 5768 7044 5781 22915 10490 29789 5880 197 213 1432 1398 51368 5552 22927 2162 146850 1072 2277 5594 7066 5595 7534 4352 10916 6464 6403 998 7078 5777 7873 5906 3273 1521 6414 308 3700 5340 11343 5341 5345 3959 54676 1893 259215 78991 6678 9948 6694 7424 5004 5770 7423 334 5919 55664 3481 3932 374354 3479 10447 5005 27154 335 2812 51266 2316 51706 5747 2815 2814 346562 23533 7410 207 88 7409 8503 10451 5336 10257 2534 1445 6850 10487 2771 808 2770 5216 5478 10125 2773 351 87 2793 2792 2791 5660 2790 2788 2787 2786 2785 2784 2783 51764 94235 3674 5473 9630 55970 928 54331 59345 2767 2769 7277 150 151 152 2776 5582 2782 10681 5028 5196 64805 7040 226 7422 6810 2621 3309 5627 7042 948 7076 2151 2149 2147 7043 139322 9002 5580 5321 3827 5578 5054 3710 1675 6647 3937 5579 27040 2244 2266 7414 54518 7450 3690 5894 2243 3708 7094 3709 5908 5265 2811 408 409 2153 7057 2157 710 7018 1191 5581 5583 9162 8527 26090 8525 8526 57406 221955 160851 1609 747 1608 1607 1606 1950 139189 7222 4067 7225 3082 5590 387 5294 5295 5296 57113 5290 5170 5291 2335 80739 2207 51206 3920 10630 391 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1971475 Glycosaminoglycan-protein linkage region biosynthesis 64131 64132 6382 2719 126792 80146 221914 9672 1462 9917 2239 135152 27087 63827 1634 26229 633 1464 1463 3339 10675 2262 11285 92370 2817 6383 10082 6385 375790 UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases 8331 5708 8607 5709 8337 125476 8334 5700 5701 93973 8335 5702 29844 5704 54891 5705 79913 5682 54617 5683 5684 283899 5685 83444 5686 4092 5717 4798 5718 5719 10445 11047 5713 5714 7979 8473 5690 5691 5692 8338 5693 7040 5694 7311 5695 7314 5687 7046 5688 7048 5689 86 4738 7528 3013 60 9958 114785 51377 3054 55252 55777 3607 7345 317772 7347 92815 221937 85235 123228 8969 8314 171023 221613 221656 9861 6233 7316 580 10213 5706 5707 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451307 Activation of Na-permeable kainate receptors 2898 2897 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 96%140179 Amine Oxidase reactions 4129 4128 196743 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants 2064 1956 4893 6654 3084 3265 5295 3320 55914 9542 5290 5335 10718 145957 2549 6464 685 1950 11140 2069 1839 CO-INHIBITION BY BTLA%REACTOME DATABASE ID RELEASE 96%9927353 Co-inhibition by BTLA 8764 151888 5781 5777 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9940465 ChAHP complex assembly 8331 3013 8337 8334 8335 255626 8341 11335 3018 8342 3017 8347 3014 8348 8345 8340 1108 474382 8970 10951 128312 8338 85236 8349 94239 22850 55766 23394 8968 653604 8370 54145 RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696273 RND1 GTPase cycle 9462 394 7037 81839 27316 9352 10817 2319 57449 56667 857 11180 5361 55789 94240 1362 22852 2886 27289 222584 55704 1832 22800 8502 23592 5295 11075 5296 91544 9231 1969 57579 57216 224 5783 667 9528 9928 10963 10818 2909 57498 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 96%428890 Role of ABL in ROBO-SLIT signaling 9353 25 6091 23332 10486 23122 10487 27 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674404 Sorafenib-resistant PDGFR mutants 5156 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding 55330 54885 152503 27243 26258 8907 8775 2804 130340 3482 84062 9698 10053 1176 1174 64746 8905 23557 162 351 164 10618 408 9146 6456 4952 1213 1211 6810 2512 8729 2495 8673 4074 2647 1777 8546 375 6844 1212 3312 10717 6845 7037 8906 9179 23431 134829 157807 81567 1522 8301 1785 11154 9829 5878 5286 51429 2580 2799 1362 25977 9026 8773 9685 7164 388552 7163 6272 286451 6643 27131 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 96%264870 Caspase-mediated cleavage of cytoskeletal proteins 841 836 839 840 2620 7431 118 4137 6709 28988 5339 2934 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis 10062 6256 5105 8204 6257 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p 440138 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 96%381119 Unfolded Protein Response (UPR) 468 51726 7094 118 5393 11340 22894 10130 23016 8570 58477 22872 23404 6745 10897 5073 10525 2081 51010 54512 153222 90993 51013 64764 56915 9797 118460 4189 5526 440 2673 10106 1388 1663 148327 1965 8894 9709 7466 3068 55062 1968 10954 1639 9695 30827 1054 116138 7709 56005 27230 81501 55033 9114 1200 2134 10113 6734 2137 10488 64061 2135 11015 9820 9570 3309 6464 811 37 84699 3576 100137049 1051 51360 4000 1649 2931 5611 4800 55738 4801 4802 6347 84447 3484 167227 7184 22926 8720 9451 467 6818 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production 57105 2687 1800 10800 2678 64174 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 993 5685 994 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 6500 7027 890 5687 5688 1019 595 5689 1017 898 51343 6502 91768 7465 286826 4149 9134 132660 1027 1026 91750 1163 5753 7029 1869 55957 4331 5925 1022 1875 1874 8900 902 4609 10000 207 208 9861 8454 6233 7316 5928 10213 5934 5706 5707 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME%R-HSA-5619115.5 Disorders of transmembrane transporters 23636 9972 9631 7175 6833 11097 2646 23511 8086 8021 53371 10613 8480 10762 56606 91445 6048 91319 10956 9187 19 6523 215 6514 6531 23443 6584 27248 5002 246213 79139 340024 6505 54716 6507 51009 9056 6400 153201 6520 11254 11136 6519 64241 348995 64240 57122 335 21 6005 55746 6521 3098 23279 6528 79023 10060 6396 7415 9861 6233 7316 3767 10213 5706 5707 5708 5709 5903 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 79902 5714 7979 5690 5691 5692 5693 5694 60482 7311 5695 7314 55343 5687 10559 5688 551 1836 5689 4891 552 553 554 30061 26503 26154 8647 9197 368 116085 5826 8671 6530 123041 10999 9843 6524 10599 7355 5172 55630 1356 1811 6513 10058 6566 9152 682 6575 5244 55788 28234 81031 55315 10568 283652 6569 6578 142680 6557 6559 2645 9990 10479 285195 11160 9883 129401 9688 1080 23225 4927 23165 1244 55706 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 96%72165 U12 Dependent Splicing 22916 4686 10992 6432 23450 6431 23451 10594 6427 6426 5440 5441 2963 2962 5434 5435 5436 5437 5438 4904 5439 51639 5430 5431 5432 5433 154007 85437 11066 8233 10081 79622 55599 10262 55954 11325 9343 10907 6632 6628 24148 23020 6634 9410 6633 83443 9416 6636 6635 6637 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) 3777 51305 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins 7097 7096 245913 245936 245937 245938 245939 503618 613210 613211 245930 503614 245932 245911 245934 503841 641517 117285 613209 400830 1673 140850 1672 245927 245928 245929 245940 55894 81623 100133267 729230 140881 644414 504180 1235 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME%R-HSA-5609975.6 Diseases associated with glycosylation precursor biosynthesis 130589 2592 116150 5236 22845 54344 79947 5373 4351 10020 79644 2673 8813 2584 2582 8818 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 96%9665250 Resistance of ERBB2 KD mutants to AEE788 3320 55914 2064 11140 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112122.3 ALKBH2 mediated reversal of alkylation damage 121642 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9702509 FLT3 mutants bind TKIs 2322 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181430 Norepinephrine Neurotransmitter Release Cycle 8497 8499 10815 10497 4128 9256 6844 6616 6857 6804 22999 8500 8541 6571 6582 6580 5864 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 96%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 633 1464 6382 1463 3339 10675 2719 126792 221914 2262 9672 1462 2239 2817 63827 1634 6383 10082 6385 375790 HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones 84678 7404 23210 80853 23081 84864 8968 9682 10765 653604 221656 55818 8370 22992 51780 23028 8242 5253 5927 23133 8284 23135 55693 23030 84159 7403 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 96%9918476 Assembly and Release of Dengue Virus Virions 4067 5045 4691 8729 9685 4904 10945 7251 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling 389 6093 4628 5879 79784 10398 10507 388 6237 3984 2064 3985 4629 387 27289 23365 9475 5364 9826 4233 2909 103910 4627 4637 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME%R-HSA-4717374.4 Defective DPM1 causes CDG-1e 54344 8813 8818 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 96%499943 Interconversion of nucleotide di- and triphosphates 25961 79077 1635 2745 56474 102157402 6240 51727 122481 1503 1841 203 204 221264 7295 26289 205 4832 4833 10201 158067 7296 6241 7298 50484 2987 4830 4831 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 96%5689877 Josephin domain DUBs 7415 5886 5887 4287 7314 6233 7316 126119 92552 5071 9929 7311 TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis 57678 346606 64900 2713 2712 2710 150763 23175 9663 8694 392636 80168 84649 116255 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III 92421 27243 51807 128866 27183 10381 10383 10382 112714 79643 51652 7846 84790 9798 221496 200014 84617 260334 6683 347688 347733 7277 29082 7278 91782 25978 81027 79861 113457 7280 10376 80086 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose 54344 8813 8818 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 96%168181 Toll Like Receptor 7 8 (TLR7 8) Cascade 2353 841 7186 8767 4615 4791 57162 84166 4205 10454 7334 6285 7335 929 6288 11274 7189 64127 80231 353376 6283 148022 3146 3663 51295 257397 51135 9261 4214 23118 9683 9684 6195 1432 10392 28512 79155 57161 79671 5594 177 5595 121457 246330 28511 3656 9097 466 5600 51231 1849 7867 1848 1846 1845 5604 23643 4208 51284 7099 51311 1386 8454 6233 7316 1326 6885 23291 80216 92610 1147 5519 3665 4790 351 4792 5515 6197 6196 4793 5516 5518 8945 3725 3654 5528 7311 5970 7314 6500 121260 3551 8517 5608 5609 6416 5601 5602 5606 5598 2002 5599 7157 9252 54106 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium 129880 92482 27241 22948 8195 84100 6950 7203 123016 55212 6608 2847 117177 79738 10694 582 10576 583 6753 166379 54585 10575 585 PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.6 PI3K AKT activation 5296 5290 5291 4803 8660 387 4914 3667 5295 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.5 Signaling by NOTCH1 23462 79885 8650 408 83737 409 3280 8850 9794 7089 83933 7311 92737 8788 4851 9978 7091 7314 113878 6500 1272 1840 3066 5663 10046 5664 388585 55851 83464 23385 51107 26508 9612 9759 22938 7088 3065 84441 1024 9734 2033 6907 4609 23220 26960 3091 2648 9148 79718 28514 182 54492 57534 102 54567 6868 51564 3714 142678 8841 10013 9611 23493 10014 1387 3516 8454 6233 7316 55869 892 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357956 TNFR1-induced NF-kappa-B signaling pathway 1147 7132 8737 10616 329 7186 330 331 3551 9099 27005 220213 10454 7185 8517 56957 7375 55072 81858 257397 1540 9825 8717 10133 23118 7128 10399 6885 7124 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C 5708 5709 5700 51529 5701 7321 5702 5704 8881 64682 5705 25906 11065 5682 8697 5683 7324 5684 10393 29945 27338 5685 119504 5686 29882 5717 5718 246184 5719 996 11047 51434 5713 51433 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 5689 51343 9861 6233 7316 10213 5706 5707 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 96%162588 Budding and maturation of HIV virion 92421 55048 5478 89853 27243 155382 128866 137492 27183 93343 10015 7251 51271 79720 51510 51534 79643 51652 7311 7314 29082 23327 91782 25978 6233 7316 9525 51160 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer 3002 3065 3726 3587 3662 192670 1051 6774 27161 891 26523 597 7291 6194 1786 9978 4869 6500 57690 192669 2305 5551 29851 6776 51530 8454 5594 5595 7535 5925 5777 4343 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism 56953 7378 4907 1807 151531 1890 1806 51733 84618 64902 30833 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-HSA-428930.4 Thromboxane signalling through TP receptor 9630 2769 55970 2793 2792 2791 2790 2776 2788 2787 6915 14 2782 2786 54331 2785 59345 2784 2783 10681 2767 51764 94235 10672 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%381042 PERK regulates gene expression 468 3576 1051 5393 11340 22894 23016 8570 23404 5073 51010 54512 1649 51013 56915 4800 118460 4801 4802 440 6347 1965 8894 9709 1968 3484 1054 167227 22926 9451 3309 467 RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway 9249 8854 64577 1592 157506 1381 220 5959 195814 57665 56603 10901 216 8608 340665 51109 124 126 127 112724 10170 8644 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling 9542 10718 145957 4893 685 6464 6654 3084 3265 2069 1839 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%2161517 Abacavir transmembrane transport 9429 6582 6580 6581 5243 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 7157 890 25946 144455 57060 1017 8900 898 9134 1027 1026 79733 1869 1820 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 96%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 3678 3339 3690 2697 207 781 782 783 59284 784 3688 24145 8912 9780 3685 6696 5027 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%2029485 Role of phospholipids in phagocytosis 5338 3710 2209 10768 3708 122618 5337 3709 5581 2214 2212 5295 5296 196051 23646 5290 84513 5335 5580 5291 5336 8398 6850 917 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 96%3304347 Loss of Function of SMAD4 in Cancer 4087 4088 4089 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%937042 IRAK2 mediated activation of TAK1 complex 7314 10454 6233 7316 7189 6885 257397 3656 23118 7311 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 96%2995383 Initiation of Nuclear Envelope (NE) Reformation 9133 4001 8815 5515 23592 5518 891 7443 3837 983 3930 22933 221496 5520 2010 23141 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 96%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 79658 5062 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 96%114452 Activation of BH3-only proteins 7529 5599 7531 140735 10018 2810 23368 27113 5533 90427 596 10000 572 7157 7027 8626 7159 7532 207 208 637 7161 7029 7534 1869 10971 7533 8655 5534 5366 SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702624 sorafenib-resistant FLT3 mutants 2322 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 96%9032500 Activated NTRK2 signals through FYN 1795 5879 627 2904 6714 4915 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-HSA-392451.5 G beta:gamma signalling through PI3Kgamma 55970 54331 59345 10000 2793 2792 23533 2791 2790 387 207 208 5294 2788 2787 2782 2786 5170 2785 146850 2784 2783 10681 51764 94235 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling 5478 4507 3593 3592 5062 7297 4001 5908 6648 4478 6627 5034 5721 6950 3572 5898 1072 3313 829 998 3181 3185 821 375 6772 6774 6845 6888 3458 9466 9987 654483 27250 302 1265 5306 9446 10148 9244 9049 3716 6775 149233 3936 4282 759 5055 3595 3594 246778 6175 6647 2939 3717 3586 DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 96%5609976 Defective GALK1 causes GALCT2 2584 AGGREPHAGY%REACTOME DATABASE ID RELEASE 96%9646399 Aggrephagy 7314 7334 7335 140735 5116 1781 5071 10013 1780 7415 3320 3297 1778 1080 6233 200894 8100 7316 1068 8655 51143 1783 11315 7311 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190370.4 FGFR1b ligand binding and activation 2248 2247 2246 2255 7049 10755 27006 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 96%912526 Interleukin receptor SHC signaling 3718 3561 3635 3636 3716 3563 3560 6654 1437 1439 1438 3568 3567 3562 5295 5296 3559 8503 3558 5290 5291 5293 6464 3717 9846 5777 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism 1727 1528 6513 119391 6515 9446 9962 9963 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 96%913709 O-linked glycosylation of mucins 114805 2650 168391 93010 192134 63917 117248 10678 51146 146712 51301 26290 50614 57452 79623 10164 9334 9331 2591 79369 143662 79695 118430 4582 4583 2589 4584 4585 4586 200958 727897 56667 29071 10610 6483 6482 6484 6487 10071 6480 94025 10331 256435 140453 27090 4588 4589 283463 8693 56913 2590 55568 394263 442117 374907 84002 11227 11226 374378 51809 64409 84752 140687 9245 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-HSA-8949215.3 Mitochondrial calcium ion transport 7419 6547 286097 3954 90550 8165 91689 6687 9512 10939 23203 55486 55013 80024 79568 221154 5245 11331 7417 30968 7416 10730 10367 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 96%1483248 Synthesis of PIPs at the ER membrane 55300 5297 8898 22908 6305 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 96%111452 Activation and oligomerization of BAK protein 578 637 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors 3320 10525 8578 811 10808 338 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a 6484 6487 2589 6480 256435 27090 10610 6483 6482 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME DATABASE ID RELEASE 96%5339562 Uptake and actions of bacterial toxins 808 22987 112755 5604 127833 5605 928 9899 6843 10015 9900 6844 6616 6857 6804 3320 3326 2984 7296 1938 5045 5609 6416 79849 1839 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 96%139853 Elevation of cytosolic Ca2+ levels 3710 7225 6786 5023 80228 5024 3708 9127 3709 5026 22953 5025 57113 84876 5027 7222 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 7157 332 7159 8626 10397 9540 604 79370 7161 23368 5875 5876 1121 64065 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 96%9012546 Interleukin-18 signaling 240 3606 8809 3565 27178 3596 10068 8807 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943965 CHD3, CHD4, CHD5 subfamily 8331 8337 8334 8335 1107 53615 8341 11335 8342 8347 8348 8345 8340 1108 9219 10951 8338 85236 8349 3066 7341 114825 125997 170394 8370 85509 5105 57504 8099 26038 55205 9112 6941 7329 22806 22807 3013 57592 23613 3065 10263 7182 8932 255626 9640 7026 10320 152485 84295 3021 3018 3017 3014 474382 57459 5931 8970 128312 54815 94239 55766 22850 23394 8968 653604 2203 54145 2538 5928 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins 8331 8337 8334 8335 1107 10155 53615 8341 155054 8342 8347 8348 8345 197320 65251 8340 1108 147686 9219 162967 162963 8338 25799 85236 8349 6940 3066 284306 8370 81931 91661 7767 125893 147658 57504 9112 7329 6613 3013 3065 55422 90075 255626 84911 10793 7695 55729 113835 3021 3018 3017 3014 57693 79862 9869 474382 57459 5931 7700 8970 128312 7562 54815 94239 55766 8968 9422 7576 340252 653604 285676 162655 54145 5928 7581 23468 INTERLEUKIN-7 SIGNALING%REACTOME%R-HSA-1266695.10 Interleukin-7 signaling 8835 3718 6774 8651 3561 3716 8968 3082 653604 5295 5296 6777 6776 8503 8660 54014 3575 5896 5897 85480 6597 3574 3667 64109 1154 KIDNEY DEVELOPMENT%REACTOME%R-HSA-9830369.1 Kidney development 6299 130497 79192 54361 2296 2668 10736 57526 2303 652 3237 3214 3975 5076 3955 5455 3207 6928 10406 255743 2018 2122 3227 3203 3400 2674 3688 26585 51316 8516 7849 1499 9353 7484 28514 182 7481 3172 2247 2138 7490 6092 5979 153572 2625 6495 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 8106 1977 10605 1981 1974 9775 23318 1973 129563 79670 1975 26986 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 96%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 5708 5709 5700 5701 5702 5704 5062 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 5689 9861 6233 7316 10213 5706 5707 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate 55825 11001 10478 5264 26061 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME%R-HSA-168275.6 Entry of Influenza Virion into Host Cell via Endocytosis 1213 1211 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956553 OTC main chain variants cause OTC deficiency 5009 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 96%1489509 DAG and IP3 signaling 808 817 818 107 5567 108 10768 109 5568 3708 84254 3709 5581 5566 111 112 5335 5580 113 3838 114 156 115 5137 5153 5136 26960 5578 3710 5575 10645 5573 5582 5577 814 5613 5576 196883 815 816 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME%R-HSA-5579026.4 Defective CYP11A1 causes AICSR 112812 2232 2230 1583 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%8849472 PTK6 Down-Regulation 5770 5753 6725 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 96%1630316 Glycosaminoglycan metabolism 64131 64132 93010 10678 9957 9955 6448 9956 1462 8509 2990 23553 3373 135152 8372 112937 4166 3074 3073 63827 1634 26229 3425 55790 79411 2720 4958 411 3423 633 1464 1463 89944 10675 10090 8534 64711 9061 9060 222537 337876 4969 27087 29940 10894 6483 6482 6484 2683 6487 54480 4060 55454 2799 10331 55576 56548 22856 11041 11285 2331 60495 11046 10057 9653 6383 10082 6385 6382 10402 11261 8692 10855 2588 221914 9672 9435 166012 2239 960 284129 10861 2132 2131 3340 176 3339 1836 4669 347734 9334 9331 2262 1514 26503 79586 2137 2135 57214 2817 9469 9348 23563 90161 51363 51000 26035 79369 2719 5549 92126 64579 126792 80146 55501 8703 8704 8702 9917 266722 6548 3161 3038 3037 3036 113189 50515 9953 9951 92370 9394 6677 375790 11081 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 96%9005895 Pervasive developmental disorders 808 3065 79718 25942 814 9612 6907 2874 8841 5566 9611 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol 6194 23160 92856 51602 51096 5822 115939 114049 57647 55226 10199 22984 11056 10885 10171 84916 27042 55127 84128 51202 9790 55813 27292 56902 88745 55272 10607 84135 51118 10813 11103 65083 1736 25879 27340 27341 6201 55623 55505 6203 9136 51504 134430 79050 4809 54555 4839 54433 8602 9277 55651 2091 25926 10528 10436 57050 51077 9724 6208 6187 DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME%R-HSA-9853846.1 Defective ANO6 does not expose PS, PE on the platelet membrane 196527 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 808 23265 7531 60412 54536 2810 9371 53632 6814 10640 11336 5879 149371 6810 55763 5898 4012 7534 10971 5867 7533 55770 7529 5563 6844 5564 5565 11127 5571 8766 57186 79058 57148 10890 5872 23216 6517 9882 51552 9847 7532 4641 207 51422 208 22920 8773 4644 4218 4627 TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 96%9839394 TGFBR3 expression 3070 5914 4088 6925 4089 4617 4618 4654 192670 4656 27161 2033 6929 26523 6667 27327 23112 4613 57690 6938 192669 6256 7049 83855 4343 GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70370 Galactose catabolism 130589 2592 231 5236 2584 2582 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 96%3359469 Defective MTR causes HMAG 4548 4552 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 96%433692 Proton-coupled monocarboxylate transport 6566 23539 682 9123 9194 133418 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 96%1433617 Regulation of signaling by NODAL 6997 93 6998 199699 9350 4838 10637 7044 55997 130399 92 91 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 96%1483196 PI and PC transport between ER and Golgi membranes 23760 LIPOPHAGY%REACTOME%R-HSA-9613354.4 Lipophagy 10226 5571 53632 123 5563 3312 5564 51422 5565 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME DATABASE ID RELEASE 96%9637687 Suppression of phagosomal maturation 7314 4843 26276 7879 51606 3837 6233 7316 9146 5868 11151 3836 7311 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 96%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 6299 6997 2247 6657 27022 5460 57167 7547 79923 2041 55211 6774 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation 51606 920 3932 160 161 375 163 1175 1173 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants 238 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 96%2559582 Senescence-Associated Secretory Phenotype (SASP) 8331 8337 8334 51529 7321 8335 2353 8881 64682 25906 4790 11065 8697 7324 6197 10393 6196 29945 8341 27338 8342 119504 8347 29882 8348 79813 8345 246184 996 51434 8340 3490 51433 3725 8338 7311 85236 5970 8349 7314 890 1021 1019 3552 1017 10919 51343 6195 8370 1027 1026 27287 5594 5595 5598 1032 1031 1030 1029 3013 3569 255626 3576 8900 1051 6774 3021 3018 3017 3014 474382 8970 128312 94239 55766 8968 653604 6233 54145 7316 DAG1 CORE M2 GLYCOSYLATIONS%REACTOME%R-HSA-8932504.1 DAG1 core M2 glycosylations 29954 146664 1605 55624 10585 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181429 Serotonin Neurotransmitter Release Cycle 8497 8499 10815 10497 9256 6844 6616 6857 6804 22999 8500 8541 6571 8224 5864 6854 6853 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 96%5696394 DNA Damage Recognition in GG-NER 8607 125476 10980 93973 142 29844 54891 79913 9318 50813 54617 10038 10920 283899 83444 5886 5887 1643 60 4798 8451 2873 10445 8450 51138 7508 10987 1642 7311 9978 7314 86 1069 6233 7316 8533 7528 64708 RHO GTPASES ACTIVATE PKNS%REACTOME DATABASE ID RELEASE 96%5625740 RHO GTPases activate PKNs 8331 8337 4628 10398 79784 8334 388 8335 7531 8341 2810 8342 8347 995 8348 8345 8340 23081 354 3817 8338 85236 8349 389 5879 4629 8370 7534 367 10971 7533 103910 4637 3013 7529 255626 3021 5500 3018 3017 3014 474382 8970 128312 10499 94239 55766 8968 5585 7532 5586 387 29941 653604 5058 5170 54145 23028 4660 94274 4627 4659 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD 152926 594 1629 1738 593 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 96%3371453 Regulation of HSF1-mediated heat shock response 23636 91582 5903 9972 9529 9631 10049 7175 3308 11097 23511 8086 8021 53371 7531 8480 10762 79902 2932 9261 5594 3313 5595 3309 3304 472 3312 9532 348995 3306 3305 57122 6117 55746 6119 6118 23279 79023 6396 10808 27000 23411 259217 3297 116835 9883 129401 7266 9688 51182 573 3337 6767 23225 51501 57805 4927 9531 22824 23165 6782 9530 55706 3310 545 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%449836 Other interleukin signaling 282618 3716 3603 6382 6809 146433 920 200081 5657 5803 1435 7297 3588 6810 6844 1436 6616 6804 1441 836 9235 163702 1440 6813 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 96%9610379 HCMV Late Events 92421 8331 55048 23636 89853 5903 9972 8337 11267 9631 27243 7175 440689 51028 8334 155382 11097 128866 137492 23511 8335 27183 8086 93343 8021 7251 53371 8480 51271 79720 10762 84313 8341 79643 8342 8347 51652 8348 8345 8340 79902 8338 85236 8349 29082 91782 25978 8370 3013 5119 255626 3190 3018 3017 1052 348995 57122 8970 317772 128312 92815 85235 55746 8969 221613 23279 8968 79023 6396 653604 9883 129401 9688 23225 4927 23165 51160 55706 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70921 Histidine catabolism 26 144193 57571 3067 3034 131669 3176 138199 10841 EICOSANOIDS%REACTOME DATABASE ID RELEASE 96%211979 Eicosanoids 66002 6916 126410 5740 1580 1579 1582 57834 284541 8529 4051 11283 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER 54107 3980 5981 7515 5982 5983 56655 3978 5111 6117 5984 7311 5985 5424 6119 7314 5425 6118 5426 5427 10714 51426 57804 6233 7316 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%196108 Pregnenolone biosynthesis 112812 2232 2230 6770 147323 83930 231 10948 706 134429 9256 1583 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport 5708 23460 5709 5700 5701 5702 5704 5705 10613 5682 5683 5684 5685 5686 5717 5718 91445 5719 6048 11047 5713 5714 7979 11194 22 5690 23456 5691 23457 91319 5692 10349 5693 89845 5694 9619 85320 10956 7311 1965 8894 5825 10347 5695 20 7314 23 1968 24 340273 5687 10350 5688 64137 215 23461 5689 10351 8504 225 27248 26154 79139 368 51009 4363 6400 10058 5824 5244 5243 64241 64240 335 21 10060 11160 7415 9861 6233 1080 8714 7316 3767 10057 10213 10257 5706 5707 1244 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451306 Ionotropic activity of kainate receptors 808 2900 2899 2898 1742 2897 83988 1741 1739 2901 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes 9134 1017 5925 898 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 96%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) 6505 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 96%216083 Integrin cell surface interactions 91522 3672 1297 3673 7412 3675 3690 3655 3679 2243 1305 1307 960 3688 5175 3680 7057 999 3339 7087 3791 3681 3682 3693 3684 22801 3683 3695 3371 83700 961 3687 3689 3386 58494 3381 1311 2200 6696 3674 3676 3678 8515 682 3696 3694 8516 3685 4060 50848 1286 1285 1284 3385 1282 3384 3383 80781 1299 2335 1298 2244 2266 375790 7448 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis 4086 4089 1107 1346 688 10001 53615 1050 1108 9314 51129 7040 29079 4023 1019 3066 896 9612 9862 57504 90390 168544 655 1879 3192 9112 3952 10974 64641 27332 63976 2167 7350 948 1959 1149 84498 83401 3065 9967 23090 55588 80306 96764 2033 5346 1052 6907 80205 57459 8648 10891 54815 51003 10499 10498 79718 6604 133522 84246 8841 9611 1387 9443 23054 9412 5469 9441 85441 9442 5928 9440 8202 51586 400569 9439 55090 4790 23097 6837 9219 9477 112950 5970 81857 7480 219541 6256 5465 54797 5105 5468 7026 1024 1051 23389 9282 9968 9969 5931 9370 6517 6721 7471 10025 7124 892 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-HSA-6803211.2 TP53 Regulates Transcription of Death Receptors and Ligands 23368 7161 355 7157 7159 8626 3486 8794 8795 8793 124446 8797 DISEASES OF GLYCOSYLATION%REACTOME%R-HSA-3781865.4 Diseases of glycosylation 5236 1462 4853 4854 4855 4166 3074 3073 63827 1634 26229 2720 4958 633 1464 1463 10675 79087 85365 29929 10195 79796 9526 56052 79053 1798 91869 9060 7841 5373 4351 4969 4247 2683 6487 4060 22856 11041 11253 1605 11285 2331 6383 10082 6385 2584 2582 130589 6382 199857 2592 79868 221914 9672 440138 22845 2239 5476 10020 79644 2673 8813 7057 2132 8818 2131 4851 176 3339 1836 116150 2262 54344 79947 4758 2817 9469 145173 57188 2591 143662 2719 79695 10417 5549 118430 10418 170689 171019 126792 54437 3955 9510 9037 4582 5199 4583 7058 4584 4585 4586 200958 157869 29954 727897 56667 29071 9507 80070 10585 140766 9508 9509 10071 94025 339366 221981 79875 81794 140453 55901 4588 4589 113189 81792 55624 283463 9719 56999 56913 11093 394263 11173 11096 11095 11174 9215 80731 170690 54507 170692 375790 92949 170691 11081 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias 6833 3767 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome 411 FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm 1499 4087 999 4088 2626 4089 8320 64321 6862 145258 83881 7852 2627 3170 6934 SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections 100128731 8678 23479 81631 7405 6185 23476 160 6184 161 2932 746 163 1603 5781 1175 1173 5777 84061 91662 22863 27072 6772 11282 7841 29801 25921 253832 23339 7991 51201 55741 11320 51125 201595 10000 4247 51304 3703 4249 10610 6483 6482 23765 6484 3716 6487 4245 4124 1650 6480 25834 684 23193 7532 11311 256435 79844 10465 5479 2530 27090 11253 207 5589 10800 208 51114 7409 64601 29108 7415 9868 114548 5133 5336 5928 6383 10082 5094 6385 6850 65082 695 6382 3718 3554 7297 79685 8819 7097 1901 7096 6773 221914 3460 9672 29760 3459 112744 51185 973 23186 2239 974 3454 51742 10280 10284 2342 64426 3654 84818 25855 2339 5926 3107 10362 3106 51317 3339 3134 3133 9908 2697 10146 2262 3135 2817 6441 3178 3676 2719 7555 57617 85437 23367 55823 11123 26276 9111 9360 9883 3605 129401 26007 9688 23225 4927 23165 375790 55706 23636 9972 9631 7175 11097 23511 3276 8086 8021 53371 8480 10762 6230 6231 6234 6235 8767 6191 6193 6192 6194 6227 6229 6228 3066 7187 64127 9641 10392 3921 57504 3656 9636 9112 821 3320 2197 2589 3837 54956 140032 143 3838 2931 56965 63982 83666 79668 203859 84875 54625 6201 54815 6203 6202 57101 203068 338440 6210 51065 6205 6204 6207 6233 6206 7316 6209 6208 6885 6188 5706 6187 6223 6189 55107 6222 6224 1147 6218 6217 4790 861 4792 2810 55129 50636 7284 196527 57719 9219 7311 5970 7314 121601 3551 8517 7341 1514 2908 7329 1452 3105 1107 567 3688 1108 30011 4869 10454 7334 7335 6654 7189 257397 23118 7534 10971 5978 7533 64135 3442 7529 3065 3441 3440 23586 80143 84282 57506 3452 3451 3449 3448 3446 3445 3444 3443 2033 7706 6733 6732 57459 857 4780 4690 3615 1387 3614 8829 23028 2288 2280 1655 5478 6093 7531 10728 9475 3326 9978 5045 7113 59272 26762 6667 51128 9871 9632 1312 10427 5289 10802 10484 30849 54106 92421 8452 27243 4088 128866 4089 834 3570 53615 83737 79643 51652 8737 11035 29082 91782 25978 5925 6232 348995 57122 476 477 478 55746 53822 89122 53826 23279 51284 79023 53828 51311 480 4153 481 6396 482 483 486 5348 5349 5648 3717 5903 340061 3665 79902 7082 9817 3456 7428 29110 3661 5931 81030 598 1915 10207 92359 64398 50628 6632 6628 79760 54960 6634 5170 6633 6636 6635 58505 6637 25929 79833 6607 8487 11218 MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%193993 Mineralocorticoid biosynthesis 1589 1585 3284 3283 3972 1081 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 96%9031525 LXRs regulate gene expression to limit cholesterol uptake 7376 10062 6256 6257 29116 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 96%181431 Acetylcholine binding and downstream events 1137 1136 1146 1135 1134 1145 1144 89832 8973 1143 1142 1141 1138 55584 SARS-COV-1-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9692914 SARS-CoV-1-host interactions 6222 5478 6224 6218 4088 6217 4089 834 340061 7531 4790 861 4792 83737 2810 11035 6230 6231 6234 6235 6191 6193 7311 6192 5970 6194 4869 7314 6227 6229 6228 7187 9641 7189 3921 6441 7534 10971 3178 7533 6232 3656 7329 64135 7529 23586 80143 57506 2033 2197 7706 3837 140032 3838 29110 6667 3661 598 11123 6201 6203 1915 6202 857 51284 684 9111 7532 10465 5479 64398 9360 6210 29108 9868 114548 26007 51065 5170 6205 6204 6233 6207 7316 6206 6209 6208 6188 5094 5706 6187 2280 6223 6189 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 96%392170 ADP signalling through P2Y purinoceptor 12 2770 55970 2773 2793 346562 2792 2791 2790 2788 2787 2782 2786 54331 2785 59345 2784 64805 2783 10681 51764 94235 2771 RRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72312 rRNA processing 5393 11340 22894 23016 23404 51010 54512 51013 56915 118460 4691 387338 54931 22868 26995 51335 81554 51106 9692 51001 55178 79922 3028 130916 84881 285367 29960 22803 51504 10528 60528 6230 6231 6234 9349 6235 6191 6193 6192 6194 51121 6227 6229 6228 51602 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 1453 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 6222 6224 6181 6218 6217 7311 9188 23160 79897 92856 54913 5394 28987 8780 51096 5822 115939 114049 81875 57647 55226 90459 10199 8568 22984 11056 705 57418 10885 10171 23246 84916 27043 27042 23481 55127 84128 51202 55131 9790 81887 55813 27292 56902 84946 117246 83732 88745 55272 10969 10607 84135 51118 10813 55720 11102 11103 65083 1736 25879 54881 26168 27340 27341 79159 55623 51388 55505 9136 55759 134430 79707 1454 79050 4809 54555 4839 54433 26354 8602 9277 55651 2091 25926 10799 10557 10436 10438 55781 10556 23517 57050 51077 9724 10200 GSD IV%REACTOME DATABASE ID RELEASE 96%3878781 GSD IV 8908 2998 2632 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9638630 Attachment of bacteria to epithelial cells 11045 4072 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME DATABASE ID RELEASE 96%9909620 Regulation of PD-L1(CD274) translation 23112 26523 57690 192669 29126 192670 27161 27327 4343 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669935 Signaling by juxtamembrane domain KIT mutants 3815 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) 54518 7450 10125 3690 2147 2243 7094 5908 2811 11069 10411 5770 2812 5747 2815 2814 150 9564 151 152 6714 6654 10235 207 1398 5170 7066 4352 2335 6464 2244 1445 2266 5906 6850 3674 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R 3481 3479 3480 4893 6654 3265 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%2682334 EPH-Ephrin signaling 6093 4628 10552 10398 79784 3984 3985 5062 71 9475 5921 25791 2048 28964 8874 1759 8997 6453 5879 1213 1211 160 6386 161 4629 163 5663 5664 3265 55851 83464 23385 51107 1969 10627 1072 998 1175 1173 103910 4637 10093 10092 10095 1212 10094 10097 7074 10096 60 4318 2904 5747 4067 8440 284656 102 7410 2045 2044 387 2043 7525 2042 1943 1942 1949 1948 1947 5058 1946 1945 10451 8218 1944 2051 2050 2049 2902 2047 2046 2041 285220 10109 64283 6383 2534 4313 8976 4627 5063 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME%R-HSA-9845323.1 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 8331 8337 8334 8335 1107 53615 8341 8342 8347 8348 8345 8340 1108 9219 8338 1788 85236 8349 3066 86 8370 57492 6595 57504 6597 6599 9112 6598 3013 3065 255626 8110 6601 8193 6603 26039 6602 6605 5977 6760 3021 8289 3018 3017 9274 60 3014 9275 605 474382 57459 5931 8970 128312 54815 94239 55766 6604 8968 143689 653604 54145 5928 29947 147646 90853 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH 8331 2208 8337 8334 8335 79885 192670 27161 8341 8342 5870 8347 4853 8348 4854 8345 4855 26523 8340 8338 83933 85236 8349 23112 57690 192669 5663 5664 388585 55851 83464 23385 51107 26508 8370 2173 7534 4343 6400 3013 22938 3065 255626 6772 3021 3018 2033 3017 3014 6907 474382 8970 128312 27327 6484 2683 6487 55766 79718 8968 8841 207 9611 653604 1387 55869 4192 2324 5087 9787 59 23129 5986 171558 4242 23286 10402 56983 10460 23509 11060 8650 8850 3725 4851 9978 5045 1272 100996717 51548 1999 100996763 388677 1024 3955 9734 26960 7157 10013 10014 892 3002 4088 83737 3280 9794 5584 7089 92737 8788 7091 113878 1991 1840 7027 595 3066 10046 1871 9612 7029 1869 84441 4904 51564 487 23493 488 489 9861 8454 6233 7316 10213 5706 5707 5708 5709 23462 5700 5701 5702 5704 5705 1956 861 5682 5683 408 5684 409 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 6500 5687 5688 5689 10959 9759 7088 4609 23220 1950 3091 2648 94239 9148 28514 182 54492 57534 102 54567 6868 142678 3714 3516 54145 P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis 4804 396 4803 4099 57142 4974 4168 84894 387 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME DATABASE ID RELEASE 96%5579022 Defective GGT1 causes GLUTH 2678 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 96%5657562 Essential fructosuria 3795 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 3030 35 1892 3033 3032 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) 6566 682 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) 2353 1108 2354 6456 1213 6457 1211 4205 160 161 6014 4893 6654 163 6016 3265 9261 2889 673 1399 6195 1432 1398 5898 5899 4803 25759 5594 5595 6300 5978 6464 10818 4914 1175 5906 1173 57498 466 5600 51231 53358 1849 7867 1959 1848 5900 1846 7529 1845 5603 5604 5605 6774 2033 3397 4208 4209 3727 1386 5519 7166 8851 6236 1020 2152 5515 6197 4066 6196 8941 5516 3398 5518 5607 429 10126 3399 8061 1759 10221 4664 4665 23237 1961 1960 7425 5528 6938 26052 116 117 5598 2002 6446 3726 4915 3400 5335 1785 6722 135 1958 387 5295 5296 9252 5290 5291 8660 3667 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation 7321 10987 7322 64326 2034 1154 8835 7347 123228 8453 4780 7415 11091 5929 9318 2873 51138 10537 55208 28952 23142 26094 6921 54939 9978 9655 23038 6923 140825 23369 54951 23363 54165 9306 149951 1161 80344 55827 23113 84259 56929 26272 79016 51122 54876 26234 50717 6468 83987 150684 8816 90864 170622 10116 64344 29099 79269 26190 51397 55884 26270 55527 23412 55666 8878 56995 28991 80067 123879 8883 122416 55294 7353 10238 10517 7323 84261 26224 54461 8533 64708 8452 10980 84078 50813 10920 154881 283807 51088 9616 150726 200845 55336 6502 1026 93611 127247 401036 79791 51665 51666 142686 142685 51676 142689 80204 1643 8451 57542 8450 1642 51514 23014 25793 10072 11275 64410 222235 79594 54850 140456 140458 26043 140459 90135 146330 9861 140460 8454 140461 6233 140462 7316 54620 10213 5706 23291 115290 5707 5708 7704 5709 55958 8139 390594 5700 332 5701 5702 84961 5704 139285 5705 122769 5682 5683 5684 55175 5685 27252 5686 5717 51130 5718 114907 5719 8945 11047 9903 5713 5714 7979 5690 92369 5691 5692 126433 5693 26259 5694 7311 5695 201456 7314 6500 80028 144699 899 5687 84861 5688 5689 26268 90293 84727 92591 26263 26267 53339 10489 285231 4738 89890 9820 26235 26118 79176 26232 84085 4008 9021 9817 51725 9039 26249 8065 140739 9040 79754 84541 672 80176 23194 7428 55832 136371 10324 25879 5931 3091 79728 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%110362 POLB-Dependent Long Patch Base Excision Repair 2237 5423 142 328 3978 8505 54936 10038 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576892 Phase 0 - rapid depolarisation 808 817 818 6336 59285 775 2259 29098 2258 2257 11280 59284 2256 55800 27092 6324 6323 9254 782 783 6331 6330 6332 6335 59283 6334 6326 6328 6327 6329 815 816 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME%R-HSA-4570464.4 SUMOylation of RNA binding proteins 23636 6613 9972 5903 9631 3183 7175 11097 23511 3190 8086 8021 53371 8480 10762 57332 8535 348995 79902 57122 7703 648 55746 6015 23279 79023 1912 51602 1911 6396 7341 80012 84733 9883 129401 9688 6045 23225 4927 23165 55706 7329 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia 64241 64240 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%1170546 Prolactin receptor signaling 2690 5618 2689 9978 6500 2688 1442 5781 6777 6776 8945 8454 3717 5617 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes 6888 1387 2033 4097 2539 7086 4780 5226 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells 4825 3651 3175 2255 390874 256297 6928 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 96%69239 Synthesis of DNA 54107 51529 7321 8881 64682 25906 11065 8697 7324 84515 5000 10393 29945 5001 27338 23594 119504 23595 29882 4998 4999 246184 996 51434 51433 23649 5422 5557 5558 1017 898 81620 51343 6502 2237 51053 9134 9861 8454 6233 7316 10213 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 3978 4172 5714 4173 7979 4174 5690 4175 5691 4176 5692 5693 64785 5694 8318 9837 7311 84296 4171 5695 9978 51659 7314 6500 890 5687 5688 5689 5981 5982 5983 8900 56655 990 5111 6117 5984 5985 5424 6119 5425 6118 5426 5427 10714 57804 1763 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%977068 Termination of O-glycan biosynthesis 143662 118430 4582 4583 4584 4585 4586 200958 727897 56667 10610 6483 6482 6484 6487 10071 94025 6480 256435 140453 27090 4588 4589 283463 394263 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination 10621 5434 5435 5437 51082 84265 55703 11128 51728 4781 9533 4782 6741 27297 4784 661 4774 5440 10623 5441 171568 55718 10622 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 96%140342 Apoptosis induced DNA fragmentation 3024 3146 3837 836 1677 1676 3148 3009 3836 3008 3007 3006 3005 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5685938 HDR through Single Strand Annealing (SSA) 5888 80010 7486 5982 5983 3364 472 2067 672 84126 144715 5893 83990 5810 5932 9156 3978 11073 641 6117 5984 5985 6119 6118 5883 5884 116028 83695 10111 25 4361 7156 4683 580 10524 2072 1763 545 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 96%416550 Sema4D mediated inhibition of cell attachment and migration 5879 5364 10507 6237 387 27289 4233 2909 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654733 Negative regulation of FGFR4 signaling 5515 5516 5518 10253 8569 7311 7314 867 9965 2254 5781 2251 8074 673 2249 2247 2246 152831 8823 6233 5594 7316 5595 2264 10818 8817 26281 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects 7027 1021 1019 595 1017 894 896 1871 898 1870 9134 1028 1027 1026 7029 1869 5925 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription 3065 1876 1875 1874 8900 4998 983 990 5111 5422 8318 7027 6241 7298 7083 26271 898 1719 81620 286826 132660 91750 7029 55957 1869 5928 5933 5934 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation 6692 3082 3249 4233 10653 3083 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9823739 Formation of the anterior neural plate 5453 5015 6656 6657 5460 2637 9839 79923 7546 5080 25925 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%73884 Base Excision Repair 8331 54107 8337 8334 8335 10038 8341 8342 8347 26277 8348 8345 25913 4350 8340 3978 8338 85236 8349 54386 2237 8370 8290 7013 65057 7014 3013 3980 5423 142 328 255626 5981 7515 5982 8505 5983 54936 56655 3018 3017 3014 5111 474382 8970 128312 6117 11284 5984 5985 5424 94239 6119 55766 5425 6118 5426 5427 10714 57804 8930 55247 54145 23583 252969 4968 79661 6996 4913 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 96%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 6487 176 4060 5549 4969 4958 11081 2331 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates 5888 80010 5889 348654 7486 472 672 675 83990 7516 5932 7517 9156 7979 80198 641 55732 79008 79728 116028 10635 146956 197342 84464 10111 4361 7156 5890 5892 4683 580 23514 63979 10524 1763 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids 126410 1573 1580 57834 1549 284541 66002 1572 1579 8529 131 1555 1565 4051 1553 11283 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function 5956 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels 170850 3784 3787 3788 7881 23416 9312 93107 23415 9132 169522 3737 3738 56479 3739 81033 3736 90134 3750 3748 3749 3785 3741 3742 3786 8514 3743 3744 3745 3746 3747 3751 3752 3754 3755 3756 131096 3757 9196 27012 27133 26251 3790 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME%R-HSA-9955542.1 CPS1 variants cause CPS1 deficiency 1373 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME DATABASE ID RELEASE 96%9818032 NFE2L2 regulating MDR associated enzymes 7975 1387 2033 10061 9429 8714 4780 4363 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly 3320 3843 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 54518 7450 3690 6714 2243 7094 6654 5908 2335 2244 5747 5906 2266 3674 INTERLEUKIN-9 SIGNALING%REACTOME%R-HSA-8985947.8 Interleukin-9 signaling 3716 6777 6776 3718 3561 6772 6774 3578 3581 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia 2538 DEPURINATION%REACTOME DATABASE ID RELEASE 96%73927 Depurination 8331 3013 8337 8334 8335 255626 8341 3018 8342 3017 8347 26277 3014 8348 8345 25913 4350 8340 474382 8970 128312 8338 85236 8349 94239 55766 54386 8370 8290 55247 54145 7013 65057 4968 7014 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 96%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 9133 891 983 5347 140609 10783 91754 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 96%68689 CDC6 association with the ORC:origin complex 23595 4998 4999 990 84515 5000 5001 23594 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 96%72200 mRNA Editing: C to U Conversion 27350 29974 164668 403314 200315 339 9582 10930 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655302 Signaling by FGFR1 in disease 11116 8805 9208 6772 6774 613 5335 2260 2549 11160 399687 4893 11052 6654 26127 2254 1523 3265 2251 8074 5295 2249 6777 6776 2247 2246 5290 10818 9846 9530 26281 7750 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 96%9793528 Ciprofloxacin ADME 213 9429 6580 9376 6579 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 96%156587 Amino Acid conjugation 10249 123876 341392 219970 92292 54988 116285 389396 348158 SDK INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373756 SDK interactions 54549 221935 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism 79018 51660 54994 10296 10048 10873 1737 347411 4200 4289 25874 25852 3948 80232 2875 2739 3945 54704 2954 7416 7311 4199 7314 1738 5162 5091 5163 5164 5165 5166 64795 23409 4750 64777 6233 8050 160287 7316 81889 92483 5160 5161 57546 55066 3939 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%1307965 betaKlotho-mediated ligand binding 152831 2264 9965 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 96%112313 Neurotransmitter uptake and metabolism In glial cells 2752 81539 6506 6507 REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 96%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 7314 7098 29110 6233 7316 7187 9641 148022 10010 10133 7311 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-HSA-1834941.5 STING mediated induction of host immune responses 5591 11277 51428 340061 3428 6778 197358 4361 29110 147945 3661 23220 7520 2547 115004 6737 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants 5156 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%5620916 VxPx cargo-targeting to cilium 23265 11336 1258 9727 149371 50807 1262 1260 378 5310 60412 5311 54536 117177 55763 8766 8729 4218 55770 6010 10640 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 96%2219530 Constitutive Signaling by Aberrant PI3K in Cancer 2064 1956 7039 118788 5155 5159 50852 4916 4233 5879 2100 5156 6714 5781 5880 2099 146850 685 2323 2322 10818 255324 2069 1839 930 3815 3084 4915 4908 9542 4909 3932 10718 627 145957 2549 374 1950 3082 23533 9965 2254 2252 2251 27006 7409 5294 8074 5295 2249 5296 2248 6801 2247 8503 2246 5290 152831 8823 5291 8660 5293 2264 940 2255 941 2534 942 9846 3667 391 8817 26281 SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT 3815 6772 6774 8651 4318 3932 7006 10019 1215 10076 10750 2242 2241 10603 5578 4067 5879 867 9402 4893 2886 9306 6654 7525 3265 5781 1111 7409 5295 5296 6777 6776 8503 5290 2887 3717 2534 9846 5777 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints 80010 51529 7321 8881 64682 25906 11065 8697 7324 51512 10393 29945 8341 27338 119504 8342 8347 29882 8348 891 246184 8345 983 996 51434 51433 8340 5347 85236 8349 25946 57060 7334 2932 64326 11200 51230 7465 1432 8370 7534 10971 7533 5600 7529 255626 3018 3017 3014 8970 128312 7514 7532 7531 993 995 4172 4173 4174 4175 4176 8318 4171 9978 1263 7157 84515 5000 5001 23594 23595 4998 4999 9088 7336 1017 10926 898 55388 9134 1027 1026 54908 6232 8655 25909 8379 9183 1063 1062 9184 1060 7468 991 151648 29086 55166 9025 1058 51720 79019 151246 63967 9735 84142 23332 79003 165918 7158 55055 81565 22919 9577 348995 79184 348235 5048 23421 57122 220134 57082 57405 147841 51143 6249 55746 4085 9656 9133 64105 8317 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 1781 23122 1780 79172 1778 81930 9861 55920 8454 84643 6233 3796 7316 9793 91687 57551 79682 10213 5905 5706 1783 23291 5501 5707 83540 5708 80152 5709 5903 2491 5519 5700 332 5701 55143 5702 5704 699 5705 11243 8924 5682 140735 5683 3619 5515 11004 5684 5516 2810 5518 5685 9212 5686 25936 5717 5718 11130 5719 64946 8945 79980 11047 10726 5713 79902 5714 5525 7979 5526 5690 55839 5691 5527 5692 5528 5693 5529 5694 7311 4194 5695 7314 6500 890 5687 4193 5688 5689 8290 51588 1029 7486 5982 5983 8900 3364 472 672 84126 144715 83990 5810 5932 990 9156 11073 641 6117 5984 5985 6119 6118 1454 1452 79858 5883 5884 116028 1111 83695 10111 4361 7156 54145 4683 580 10524 1763 545 INITIATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769735.1 Initiation of coagulation cascade 6382 3339 7450 2157 2719 2147 2155 2152 221914 2262 9672 2153 2239 2159 2158 2817 5627 6383 10082 6385 462 375790 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) 2720 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D 2799 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 10987 7979 5690 5691 5692 5693 5694 7311 5695 9978 7314 6500 5687 4751 5688 2932 5689 29126 9861 8454 6233 7316 10213 5706 5707 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 96%190873 Gap junction degradation 1601 1213 8218 1211 1759 1785 2697 1212 4646 1173 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation 8331 8337 8334 3630 8335 567 2243 351 5071 8341 8342 8347 6478 8348 8345 6477 8340 9246 8338 7045 5617 7311 9027 85236 793 23062 8349 10098 7314 23163 54959 5045 3339 4069 1471 325 9627 6288 9445 6653 23621 340348 3015 8239 6406 4878 55851 4240 83464 7276 23385 81619 796 51107 23555 8370 337 26088 3375 3013 255626 4057 3021 2934 3018 3017 3014 348 474382 335 8970 128312 8968 102 6622 653604 6233 54145 7316 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) 2997 2992 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling 57610 10048 200958 3082 4893 6654 4233 3265 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 10498 7157 7027 25946 3276 581 1874 2810 6790 2033 891 995 983 5111 7029 1647 5933 5934 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 96%5685939 HDR through MMEJ (alt-NHEJ) 2237 5893 10111 10721 3980 5932 4361 142 7515 4683 10038 675 MMR%REACTOME%R-HSA-5358508.3 MMR 5395 5424 6119 4436 5425 4437 4292 6118 2956 10714 57804 9156 5111 3978 6117 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390651 Dopamine receptors 1816 1815 1814 1813 1812 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000497 Scavenging by Class H Receptors 23166 55576 6678 338 DEFENSINS%REACTOME DATABASE ID RELEASE 96%1461973 Defensins 7097 7096 245913 245936 245937 245938 245939 503618 613210 613211 245930 503614 245932 245911 920 245934 503841 641517 117285 613209 400830 1673 140850 1672 245927 245928 245929 245940 55894 81623 100133267 728358 729230 140881 417 644414 1671 504180 1670 1668 5645 5646 1669 1235 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 6657 5460 79923 OPSINS%REACTOME DATABASE ID RELEASE 96%419771 Opsins 2652 94233 5956 221391 23596 6010 611 5995 10692 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) 116085 PEPTIDE HORMONE METABOLISM%REACTOME%R-HSA-2980736.5 Peptide hormone metabolism 23265 3630 60412 5080 54536 1215 9314 3972 2488 10640 1499 11336 5034 149371 2922 55763 2784 59272 183 1361 1066 2028 51764 3952 3798 55770 3799 1395 64924 5443 57393 2999 2688 3624 2626 3800 3623 619373 5122 7941 25924 4311 1363 290 6844 1360 83729 1359 6804 10159 1636 5873 5972 3626 3625 590 169026 1045 3479 338557 1522 5126 9789 139760 1803 43 2641 56605 7252 90701 1081 2864 1511 3670 94115 346562 28972 60559 2782 4644 1509 2695 23478 7349 6934 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME%R-HSA-165054.4 Rev-mediated nuclear export of HIV RNA 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 1104 10762 5902 348995 79902 57122 7514 55746 23279 79023 6396 5901 9883 129401 9688 23225 4927 5905 23165 55706 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 96%422085 Synthesis, secretion, and deacylation of Ghrelin 1395 2688 619373 3630 5122 7941 28972 60559 590 3479 9789 43 2641 90701 23478 7349 9314 3952 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU 5045 GSD IB%REACTOME%R-HSA-3229133.4 GSD Ib 2542 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD 2729 2730 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades 7321 2353 8651 841 8737 329 11035 7186 8767 4615 4791 57162 79792 330 7322 84166 4205 10454 7334 6285 7335 929 6288 7187 11274 8411 9641 7189 64127 80231 353376 6283 1687 148022 3146 3663 51295 257397 5781 10010 51135 9261 64145 10133 4214 23118 3684 9683 9684 6195 7100 1432 6279 10392 6280 28512 79155 57161 79671 3689 5594 177 5595 121457 246330 81793 28511 59307 3656 9097 466 5600 51231 114609 1849 7867 948 1848 11213 1846 6271 1845 5604 23643 4064 3929 671 338 9450 5775 81622 7098 4208 51284 1520 7099 5641 51311 1508 7184 1386 8454 5336 6233 7316 1326 6885 2244 2266 23291 80216 92610 695 1147 5519 3665 2243 4790 7097 7096 351 4792 5515 6197 6196 4793 5516 5518 8945 1759 3725 3654 5528 7311 5970 7314 6500 121260 3551 8517 5608 5609 1514 6416 1513 5601 5602 5606 26052 1515 10333 5598 2002 5599 29110 1785 3661 7323 7157 5289 9252 30849 54106 8772 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856825 Cargo recognition for clathrin-mediated endocytosis 9341 1601 84251 10980 3482 50813 10920 10618 26119 6453 10987 9146 6456 8027 6455 2060 8674 30011 1213 6457 1211 867 10254 160 161 163 185 1175 1173 3949 154 6869 156 1129 1856 338 6233 7316 1956 9318 7039 408 409 2873 51138 7311 7314 551 554 4738 685 255324 2069 1839 8673 127833 4074 7018 6844 1212 6857 6845 7037 23208 9185 9856 8301 115548 1861 374 915 27348 1950 23149 29924 917 8322 85439 9892 7474 920 50618 22905 25977 3267 29988 58513 157 950 143425 22848 8218 1080 6572 4036 286749 3575 90019 55707 8533 29978 64708 29979 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 96%1169092 Activation of RAS in B cells 10125 4893 25780 3265 PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling 8452 8331 7004 8337 7003 8334 7005 8335 2353 10613 100128731 192670 27161 8341 8463 8342 8347 8348 8345 91445 6048 26523 8340 10987 53632 2354 91319 8338 4791 10956 85236 1499 8349 6185 23112 23476 6184 1019 57690 595 2932 192669 746 1603 5781 2034 3123 3122 27248 3120 8370 3119 3118 79139 3115 2146 3113 5777 51009 4343 6400 3013 3127 3126 3125 255626 84061 5562 5563 6772 5564 6774 5565 3021 3018 2033 3017 3014 80380 3932 5571 7991 474382 201595 3703 8970 128312 27327 3716 83439 55766 1650 8726 8968 10331 7532 4780 3727 51176 653604 7415 1387 84661 11091 25937 9861 5133 8454 6233 23512 7316 5928 5929 10213 1445 5706 467 5707 5708 5709 5700 5701 5702 5704 5705 4790 5682 5683 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 3725 5690 5691 5692 5693 5694 7311 5970 5695 9978 7314 6500 5687 5688 5689 4297 1460 1459 1457 4609 5931 8405 915 10413 916 917 3091 94239 9070 920 4613 11160 4751 29126 142678 51422 3659 54145 58505 6932 6934 58508 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation 5442 64216 7019 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME DATABASE ID RELEASE 96%5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 8331 5087 8337 8334 8335 3199 8341 5080 8342 8347 8348 8345 8340 3725 8338 57472 85236 8349 6256 8370 5440 5441 2146 7528 7403 9125 3013 1959 5434 5914 5435 5436 255626 5437 5438 5439 3214 5430 5431 5432 5433 3021 3018 2033 3017 3014 5915 474382 5931 5916 7703 8970 128312 4211 22976 3200 9063 94239 55766 84962 9070 9935 8726 3211 8968 79447 3201 10664 3221 63925 3213 3212 5316 8841 9611 3233 3232 653604 3198 3231 1387 84661 23054 11091 8085 23512 54145 5928 5929 8202 58508 NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 1104 10762 348995 3837 79902 57122 55746 4869 23279 79023 6396 5901 9883 129401 9688 23225 4927 23165 55706 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels 3768 3761 3759 3770 PI METABOLISM%REACTOME DATABASE ID RELEASE 96%1483255 PI Metabolism 65977 59339 59338 51573 55697 9108 4534 55613 133121 80230 66036 284161 375775 5287 5288 93492 10908 8394 79153 8395 64419 54893 377 25816 5298 9896 27124 388121 8867 200576 4952 660 3635 81544 3636 54545 79626 55300 5297 8898 22908 5728 6305 90809 8396 5783 146850 5867 375 9110 5868 5286 51552 23533 23396 5289 5305 5294 5295 5296 8897 8776 8503 9107 5290 55361 23760 81846 56623 8871 5291 22874 5293 22876 30849 84725 57664 54477 51763 3631 126282 8821 7179 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome 58484 834 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 4067 2057 6777 6776 2056 8660 3717 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855167 Synthesis of pyrophosphates in the cytosol 170685 23262 11163 3705 9677 11165 64768 55190 9807 117283 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 96%9818035 NFE2L2 regulating ER-stress associated genes 468 7975 1387 2033 4780 SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 96%201451 Signaling by BMP 650 4086 3624 3623 4089 7321 64750 4091 4092 7323 57154 91851 9765 27302 4090 9241 4093 657 658 93 659 94 11167 9350 64388 2658 268 269 6497 7049 92 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 96%174403 Glutathione synthesis and recycling 124975 2686 2729 2687 2730 494143 79094 26873 79017 2678 55748 2937 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System 3764 6833 9424 3775 10089 26050 28964 22865 53632 5879 160 6714 4893 6531 3265 6511 6195 27165 5594 5595 6506 6505 6507 81539 5567 5568 5562 5563 6512 5564 6539 5565 54407 111 112 113 5571 114 115 3751 3752 3754 3755 346562 3756 5575 131096 56659 3757 3758 3770 88 22843 338567 9196 1740 2906 27012 9647 27133 8536 10021 27094 2905 3780 814 5577 3782 2903 3783 4747 5613 2902 26251 27345 3776 5576 3777 9495 51305 3790 196883 348980 57657 2771 808 170850 2770 3784 10242 3787 3788 7881 2773 83795 107 23416 108 9312 109 93107 23415 4646 169522 54207 50801 28988 3737 3738 56479 3739 610 3781 81033 3736 3778 90134 3779 3750 3748 3749 3785 89822 3741 3786 3742 8514 3743 3744 60482 3745 3746 3747 2793 2792 2791 2790 2788 2787 2786 2785 2784 23136 2783 51764 94235 55970 10313 127833 9463 3760 3761 2550 6844 3084 6616 9132 3759 3312 6857 6804 3359 55327 200909 3772 2562 22999 2561 590 2560 54331 8541 2559 18 2558 2557 1103 59345 2556 43 2555 27163 2554 140679 7915 2036 8224 26960 3762 5864 3763 80331 3765 6854 3766 6853 1312 3768 8497 27092 8499 7102 10815 2570 10497 220074 23426 2569 6532 4905 773 2567 774 2566 777 3773 6529 8825 9256 4900 6540 10645 9254 781 55879 170572 782 783 10369 784 10368 785 5582 2782 8573 6538 59283 8500 2743 57030 2742 2752 2900 2741 6571 285242 6572 2899 200959 10550 2898 1742 320 6582 27330 6580 2897 83988 116443 55799 10681 1741 116444 23229 1739 2901 64130 9568 2892 2890 27020 9177 8001 2774 80852 57576 10211 2893 84254 5923 5924 2572 2571 57369 56666 4916 10052 2319 84694 24145 81858 2911 2915 217 3838 2744 5578 5330 10060 5331 23236 4128 5573 3767 5579 815 816 817 818 5566 6197 6196 4193 22871 9066 57622 57502 79414 6812 9546 22839 11141 57669 58512 10611 91683 94030 57555 85358 9454 9455 347731 347730 9456 22829 22941 50944 8495 8496 26037 2891 5792 26045 2904 57596 2037 2035 9229 5789 8973 1143 26280 1142 9369 1141 54413 1138 84189 341359 55584 9378 1137 9379 1136 114798 1146 57497 1135 321 1134 84631 1145 78999 1144 139065 89832 80059 5802 51422 143425 5170 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose 7376 10062 6256 5346 6257 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 1582 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives 246 239 2877 242 59344 2876 2879 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73772 RNA Polymerase I Promoter Escape 8331 8337 8334 6908 8335 8341 11335 8342 8347 8348 8345 8340 54700 8338 85236 8349 8370 5440 5441 4331 1022 2071 2966 2965 3013 2068 5434 5435 255626 5437 2968 2967 404672 3021 3018 902 3017 3014 474382 221830 8970 7343 128312 25885 9014 9015 94239 9013 55766 64425 79101 8968 10849 30834 84172 51082 653604 9533 54145 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696264 RND3 GTPase cycle 29766 9462 394 6093 81839 27316 9352 8301 2319 57449 56667 3895 857 11180 55789 1362 22852 222584 7126 55704 390 1832 11188 8502 23592 54514 10970 5295 5296 91544 1152 9231 10505 1969 253980 1828 57216 5783 667 23513 2909 57584 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME DATABASE ID RELEASE 96%9665245 Resistance of ERBB2 KD mutants to tesevatinib 3320 55914 2064 11140 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 96%9036866 Expression and Processing of Neurotrophins 5045 5046 5125 4803 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 96%444473 Formyl peptide receptors bind formyl peptides and many other ligands 2359 301 2357 50865 6288 2358 351 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1432 5571 6300 53632 5563 5564 51422 10891 5565 5600 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 96%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 8924 8341 8342 8347 8348 8345 8340 7311 85236 8349 7314 7336 7334 11200 7341 8370 8290 51588 7329 255626 7468 29086 9025 51720 5599 472 672 84142 165918 7158 3018 3017 3014 9577 79184 8970 128312 5536 8314 9656 51035 2070 7157 8467 9031 322 9682 2140 2139 10111 2138 25 4361 6233 54145 7316 4683 580 10524 23030 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME%R-HSA-9865125.1 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD 594 1629 593 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME%R-HSA-9944971.2 Loss of Function of KMT2D in Kabuki Syndrome 84661 9070 11091 8085 5929 STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation 6777 6776 2323 2322 9846 5781 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 96%453276 Regulation of mitotic cell cycle 5708 5709 5700 51529 5701 7321 5702 5704 8881 64682 5705 25906 11065 5682 8697 5683 7324 5684 10393 29945 27338 5685 119504 9212 6790 5686 29882 5717 891 5718 246184 5719 983 996 8945 11047 51434 5713 51433 5347 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 6500 890 5687 5688 5689 1017 51343 6502 5925 9184 991 8900 4085 4751 701 26271 8556 9861 8454 9232 6233 7316 10213 5706 5707 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts 23636 22916 9972 5903 9631 7175 10482 11097 7884 4686 23511 8086 8021 53371 8480 10762 348995 79902 57122 55746 8189 10898 51692 23279 79023 53981 29894 6396 55339 81608 1977 9883 129401 9688 23225 4927 23165 10189 55706 SIGNALING BY INTERLEUKINS%REACTOME%R-HSA-449147.13 Signaling by Interleukins 3557 3566 5743 27177 240 3976 2208 3590 3589 7132 4312 7133 4692 7850 3593 8808 2353 3592 3598 3588 3597 5062 3587 6624 4215 2185 23529 90865 55540 5008 29949 4170 116379 53833 53832 55801 26525 59067 282617 11009 282616 50604 84868 50615 4791 50616 6813 386653 84639 58480 5034 3601 3600 3965 4843 64806 9173 5781 2162 3055 1072 998 5777 1154 8835 6772 6774 1052 4318 3932 23765 3716 1511 8968 7525 207 7409 653604 8503 1326 2534 3586 6850 80216 92610 6382 3718 3554 7297 2308 1901 6773 29760 112744 3561 3654 84818 3635 4988 3636 6627 6950 3181 3185 604 6888 3458 1278 7157 3605 4507 8767 4615 7040 84166 7422 4205 6285 6288 11274 64127 6283 51135 9683 9684 10392 5780 28512 5771 79155 5783 57161 79671 5784 177 26469 25930 121457 84867 246330 26095 8809 28511 3656 6597 59307 9097 27178 466 10068 5778 51231 1849 948 1848 11213 1846 1845 246 821 3662 3320 9466 9987 654483 27250 1265 5306 6347 10148 9244 9049 6775 149233 3936 4282 5055 3595 3594 246778 3563 3560 4128 1439 1438 3568 3567 6175 6647 9861 8454 6233 7316 10213 6885 5706 23291 5707 5708 5709 1147 5700 5701 5702 5704 5705 4790 5682 5683 4792 5684 4793 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5970 7291 5695 7314 6500 3551 5687 5688 8517 5689 3565 3596 8807 3572 6095 54014 5896 5897 85480 3574 64109 9021 2625 3726 6657 3977 6935 9252 3383 2335 79923 163702 282618 3911 3603 6809 146433 7412 200081 5657 5803 1234 3688 5721 867 10454 7334 7335 6654 7189 257397 9261 23118 2889 3684 3562 1399 3559 6195 1432 1398 3558 5898 3687 3689 5594 5595 7534 6464 5600 5443 7867 5604 1435 3162 302 5775 759 4208 2885 6777 6776 5292 729230 1386 1230 2939 4313 5451 6655 4985 5478 4001 7431 351 356 2357 6648 2309 3725 4478 9978 9655 301 2002 5782 8878 6844 375 6616 6351 3312 6352 6804 6845 6356 4582 6348 6349 6364 6363 6367 9446 3578 3581 2919 2247 2920 8660 9846 3667 3553 4088 834 3570 1441 8651 841 7006 3606 7186 57162 79792 3627 5724 3552 595 6810 3146 1026 829 3313 4314 6097 7076 3929 7184 1437 1436 3717 5519 332 6778 5908 5515 5566 6197 5516 6196 5518 5528 5608 5609 6416 5601 5602 5606 836 5598 3569 11141 3576 5599 3934 29110 4609 596 598 3091 4067 920 3082 5295 5296 5290 9180 10538 5291 54472 5293 133396 56300 27189 3575 1489 941 58985 942 132014 1271 1270 7124 27179 9235 1440 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 96%4641258 Degradation of DVL 8452 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 1855 5686 5717 5718 5719 11047 5713 5714 7979 1857 1856 5690 5691 5692 5693 5694 7311 5695 9978 7314 5687 5688 59349 23072 5689 9861 6233 7316 10213 5706 5707 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%177243 Interactions of Rev with host cellular proteins 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 1104 10762 5902 348995 3837 79902 57122 7514 55746 4869 23279 79023 6396 5901 9883 129401 9688 23225 4927 5905 23165 55706 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-HSA-3134973.3 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1499 1387 2033 3661 9208 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9012999 RHO GTPase cycle 55971 70 10395 23092 143872 10276 5099 347902 9138 4810 55619 388 10787 128239 85360 1729 8936 11214 5062 5881 128272 10152 26230 2185 29 121512 84904 64411 124056 29127 25791 613 89846 51347 26050 22899 3071 10163 50649 5364 28964 22865 8874 64857 653361 23075 57449 116984 27035 55114 2245 4952 10006 221472 55701 10672 9459 389 58480 5879 708 55200 399693 253959 23616 115703 139818 201176 57514 57636 6510 55219 55227 26092 124997 58504 1124 1123 10409 91452 114793 57679 998 114885 57569 27145 92799 57572 10602 752 55968 51133 55852 10144 64333 116985 25963 79834 9912 101059918 79822 23526 54438 157285 29062 9938 10810 23779 3932 51291 9824 56990 10435 83478 84681 7454 120 7456 84317 9644 23268 51306 147179 9411 94134 393 399 11180 51566 5361 84364 94240 171177 1362 148170 22852 23348 89839 2886 27289 23580 222584 84144 55704 2802 65992 22800 8502 7409 10160 11075 25894 91544 7415 55831 644150 51479 9231 57579 8503 54509 57216 26999 55717 224 10928 667 1730 9528 93663 9928 26049 10963 9590 57473 123720 80115 8976 158747 1445 57120 8153 57480 117289 84986 23129 343578 50619 157769 221178 257106 153478 114822 29984 11060 445582 152273 79180 80243 23074 23197 10134 2697 908 10574 10376 10576 60 23048 91010 57381 54874 2631 144402 8476 81704 9497 9578 23513 23229 8086 5924 85440 1213 23380 57522 9901 80728 29843 5783 3320 79658 9738 10250 7919 3930 5338 84612 9855 79598 387 23370 50855 54514 1080 200894 6472 7444 7204 9743 2909 391 57584 392 9341 394 57580 396 26030 397 398 80005 7879 5337 4722 10298 10652 3954 3998 9710 81839 10788 26084 26286 4698 3688 8997 6453 7984 2010 9146 23344 143098 8027 63916 3336 23141 23263 5825 1794 1793 4983 3895 8987 55789 10254 4162 6714 7112 9217 4168 6654 9732 27237 23191 81624 23592 2889 11135 6811 55240 5880 1969 55914 10818 57498 55075 27 8440 857 4650 7410 56924 4690 10451 10424 6655 11140 6434 9886 8654 57144 23221 29766 6093 3183 55023 11329 56254 5930 4001 71 9318 5756 4646 7431 9475 124540 23013 27316 9352 3326 2873 79869 51138 1627 87 6709 6711 55004 7170 7171 56667 4548 8452 9462 10211 2319 57630 8239 832 4580 25813 8776 4296 7535 8826 10726 23256 3163 1832 9414 1829 1828 537 7037 7074 1795 10817 8301 50618 6793 182 65124 5585 5586 55160 1629 23002 23365 115557 7126 9181 390 29941 11188 10970 85415 5295 1152 5296 1894 4649 10505 5058 253980 8773 6242 9754 5290 50508 2040 395 1536 3728 54443 9322 10811 9748 1535 10458 9826 55843 11113 10979 90627 64283 9815 4688 9828 284119 55845 4689 50650 9639 5063 9235 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 96%5657560 Hereditary fructose intolerance 229 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206307 MPS IIIA - Sanfilippo syndrome A 6448 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME%R-HSA-9768727.1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane 9159 821 100128731 7841 1460 9789 1459 1457 29954 90701 3703 10585 1499 283106 5045 1650 999 6185 5046 6184 23193 288 23396 746 28972 5589 1603 60559 3728 58505 23478 9743 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors 134 9934 135 136 140 27334 5031 5032 5030 53829 10161 2840 5028 2846 64805 5029 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes 9915 3630 4193 2353 10135 266743 8851 1020 1387 627 405 5594 2669 406 5595 10769 146713 5979 341359 440073 7514 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 5244 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B 26154 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 4121 10905 57134 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 3030 34 1666 1632 33 3032 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 96%8857538 PTK6 promotes HIF1A stabilization 120892 10457 5753 1956 3091 1839 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693616 Presynaptic phase of homologous DNA pairing and strand exchange 5888 80010 5889 7486 5982 5983 3364 472 672 675 84126 144715 83990 5810 7516 5932 9156 11073 7979 641 6117 5984 5985 6119 6118 5883 5884 116028 1111 83695 10111 4361 7156 5890 5892 4683 580 10524 1763 545 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 96%8876198 RAB GEFs exchange GTP for GDP on RABs 7879 57589 7531 51560 79090 6399 5861 51209 5870 22878 22879 221960 79890 2665 1121 80006 126003 2664 9827 11021 25782 9367 23682 57706 58485 10260 6764 11031 51762 23258 9909 51693 6305 79961 27342 116442 122553 5874 84315 60684 23011 8408 10981 27095 5866 84079 160518 81876 163259 83696 338382 126432 22930 22898 22931 54453 55667 27147 51399 3257 54734 51622 7109 79958 259173 57679 89781 201627 9610 163486 414918 201475 1122 51112 5873 5878 5868 5869 10000 5864 26130 10890 5872 51552 207 208 117177 81846 4218 GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation 2770 27020 2774 2773 107 108 109 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 94235 55970 3760 3761 2550 3759 3772 2562 111 2561 2560 54331 112 2559 113 2558 114 2557 59345 115 2556 2555 2554 3762 3763 3765 3766 3768 2570 2569 2567 2566 346562 3773 55879 2782 200959 10681 196883 23229 9568 2771 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) 6528 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%450294 MAP kinase activation 1147 5519 2353 4790 5515 6197 6196 5516 5518 8945 3725 3654 8767 5528 7311 7314 6500 3551 4205 10454 7334 8517 7335 64127 7189 5608 257397 5609 9261 23118 6416 5601 6195 1432 5602 10392 5606 79155 5594 5595 5598 3656 2002 466 51231 5600 1849 7867 1848 1846 1845 5604 5599 4208 9252 1386 8454 6233 7316 1326 6885 23291 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6785470 tRNA processing in the mitochondrion 3028 51095 60528 54931 9692 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation 5695 5720 5721 5687 5688 5689 5682 5683 5684 5685 5686 5698 5699 5690 5691 5692 5693 5694 5696 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 96%186763 Downstream signal transduction 6778 6772 6774 5921 5159 5155 5335 8440 5156 9564 6714 4893 2886 6654 3265 5781 2889 5295 4690 1399 5296 6777 6776 1398 5290 5291 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 96%167044 Signalling to RAS 53358 7867 5900 5603 4893 6654 3265 9261 1432 5898 5899 4803 25759 6300 6464 4914 5600 ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors 146 153 154 155 147 148 150 151 152 NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes 7975 1387 2033 4780 6347 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME%R-HSA-9917777.1 Epigenetic regulation by WDR5-containing histone modifying complexes 8331 8337 8334 8335 10001 1050 8341 8342 8347 8348 8345 10445 8340 79611 8473 51129 8338 29079 85236 8349 4023 51230 8370 9612 5925 9862 84649 90390 7403 3013 2167 948 11343 255626 3991 23175 3021 3018 2033 3017 5346 3014 6907 474382 3054 8648 8970 10891 128312 22976 51003 10499 84962 55766 79718 8968 79447 133522 4221 84246 8841 9611 23411 653604 1387 84661 9443 23054 11091 8085 5469 9442 5929 9440 8202 9439 2494 1020 8850 9477 30827 6256 10555 6871 55683 55689 57104 8800 284058 2874 729359 60481 1024 55617 7069 63924 91272 54934 23067 10474 9282 2180 4297 1810 51562 26993 26009 9968 29915 9969 9370 259282 112869 57325 84148 51105 22822 80335 57678 2648 94239 9070 6319 9739 5166 25 54145 10025 123 11168 9757 58508 892 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9971 9420 10499 1593 1581 1646 6718 1645 80270 1109 6256 1582 8648 8644 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME DATABASE ID RELEASE 96%9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 4067 2057 5335 2056 8660 5336 3717 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 96%5675482 Regulation of necroptotic cell death 355 10211 10015 7332 8743 5071 83737 841 3320 356 8737 329 11035 2319 8795 7186 8473 10273 8797 57162 7311 330 331 7314 6386 8717 197259 6233 7316 11140 8772 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 96%166016 Toll Like Receptor 4 (TLR4) Cascade 7321 2353 8651 841 8737 329 11035 7186 8767 4615 4791 57162 330 7322 84166 4205 10454 7334 6285 7335 929 6288 7187 11274 9641 7189 64127 353376 6283 148022 3146 51295 257397 5781 10010 51135 9261 10133 4214 23118 3684 9683 9684 6195 1432 6279 10392 6280 28512 79155 57161 79671 3689 5594 177 5595 121457 246330 28511 59307 3656 9097 466 5600 51231 114609 1849 7867 948 1848 11213 1846 6271 1845 5604 23643 4064 3929 671 9450 5775 4208 7099 1386 8454 5336 6233 7316 1326 6885 2244 2266 23291 80216 92610 695 1147 5519 3665 2243 4790 7097 7096 351 4792 5515 6197 6196 4793 5516 5518 8945 1759 3725 3654 5528 7311 5970 7314 6500 3551 8517 5608 5609 6416 5601 5602 5606 26052 10333 5598 2002 5599 29110 1785 3661 7323 7157 9252 8772 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity 11254 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis 5478 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173736 Alternative complement activation 629 718 1675 3004 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3359454 Defective TCN2 causes TCN2 deficiency 6948 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5675221 Negative regulation of MAPK pathway 1849 1848 1846 5519 7529 5604 5894 5605 5037 369 5515 5516 5518 5525 5526 5527 5528 5536 5529 7311 7314 4893 1852 152559 3265 1850 11221 5774 673 1844 1843 1847 4140 6233 5594 7316 5595 8315 6300 80824 8844 5778 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) 7100 4615 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%189451 Heme biosynthesis 213 7389 5498 1352 3145 7390 1371 9429 210 211 212 2235 1355 DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9920588 Dengue virus activates modulates innate and adaptive immune responses 64135 721 340061 57506 6773 1191 722 725 3320 23601 3326 7706 23168 335 79577 80349 8241 123169 9646 54623 9641 4153 1654 712 55763 716 23352 115004 7448 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 96%8964038 LDL clearance 1213 1211 51599 160 161 3988 163 23491 57552 8435 4864 6646 26119 1175 338 255738 1173 10577 3949 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 64750 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 5689 7855 1856 7976 8321 8322 57154 7474 8325 8324 50855 57216 9861 23513 2535 6233 7316 10213 144165 5706 5707 MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%5660489 MTF1 activates gene expression 1465 6620 4520 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins 1788 1786 6015 1912 1911 7341 80012 57332 84733 8535 6045 7703 648 1789 7329 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811436.2 COPI-independent Golgi-to-ER retrograde traffic 55860 51164 10671 636 23299 93661 5050 84516 5049 140735 51560 5870 2589 5321 5048 51143 25782 10121 1639 11258 1781 1780 830 22930 832 1778 2590 22931 829 10540 8398 8655 56894 1783 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9675108 Nervous system development 1297 7003 1293 388 1292 1291 5062 25791 1287 5364 28964 8874 389 5879 160 161 2932 163 5663 5664 5781 55851 83464 23385 51107 1072 1175 998 1173 5567 5568 10093 10092 10095 10094 10097 10096 4318 5361 2886 27289 7525 4651 8503 25937 2902 10109 6383 2534 8976 4627 22916 10552 23129 4686 6921 6923 2817 3674 3678 60 27330 375790 4628 79784 10507 6237 3984 3985 56896 22885 2676 2675 57556 5621 5623 971 148738 137970 64096 57211 57453 10371 5786 5788 6230 116986 6231 64218 6234 779 9349 3156 6235 56963 6191 84059 4359 6193 7402 6192 10570 6194 79966 9353 1213 57716 23380 57522 51121 54209 1211 5362 6091 9901 8633 6227 4155 80728 6229 9723 6228 11224 5365 3066 200916 5376 7305 6122 55558 6124 84448 6123 6125 1809 25873 59277 140801 220164 1821 1826 3921 4736 55816 6130 10154 6133 8482 6132 55715 6135 4902 6134 1400 6137 9260 6136 5909 80031 6597 6128 9048 9046 6129 1796 6142 285704 6141 3983 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 3320 2197 23521 140032 6164 6166 5306 6165 6168 5578 6201 6167 6203 6169 6202 116832 6160 6161 6175 9045 6210 6176 6171 6170 6173 51065 6205 9861 6204 6207 6233 6206 7316 6209 10213 6208 6188 5706 6187 6223 5707 6189 5708 6222 5709 6224 6181 6218 10398 5700 6217 5701 5702 5704 5705 1956 5682 5683 4756 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 5689 22794 9939 65109 2668 9775 10921 9855 55110 4116 5453 2674 7220 7222 7224 7223 7225 387 57113 9252 3915 2041 7204 284217 2909 3908 3912 10298 3688 8997 6453 6456 4233 219699 90249 1793 30011 6714 4893 5588 6654 3265 1969 6195 5594 5595 6464 5979 10818 53358 1959 5604 5605 6663 91584 5454 3685 5747 23053 27 23708 8440 3670 6387 23032 4753 8453 4650 9423 284656 2107 2045 7410 2044 51466 4440 2043 2042 26986 1943 1605 1942 2935 1949 56924 4690 1948 1947 9355 1946 8022 7852 1945 10451 1944 6092 2051 26019 2050 55740 2049 1630 2047 8829 2046 56956 285220 5576 4313 9495 6655 10486 10487 57144 23767 5216 5217 6093 5532 7408 89884 65110 6586 4099 2064 6585 3199 71 8851 1020 8650 24137 9475 6900 27255 11280 2048 3897 3326 10752 8828 1759 4664 1641 5962 4665 1808 3785 4478 3786 3680 6708 6709 55800 8986 285643 6324 9978 6323 1272 286 8861 287 288 4629 100133941 2596 51332 6711 6710 8128 4897 6712 11313 6331 6330 6332 7903 6335 10627 6334 1981 26052 214 6326 8912 8506 8913 6328 8911 6327 6329 7430 4684 103910 4637 23114 57698 57731 6336 8515 10048 1212 775 3312 9037 1785 1595 6721 782 783 784 785 25 8660 1742 9846 1741 1739 3672 3673 5921 6478 6477 2242 1463 6386 1600 7436 5649 776 6232 23332 23122 2887 3690 7094 5566 6197 6196 5598 85358 7074 5335 1460 1459 2904 1457 2549 10413 4067 102 23396 23365 1286 1285 5295 256076 1284 5296 1282 5058 5290 8218 5291 5293 1299 9826 64283 1298 131873 5063 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance 8331 51750 8607 8337 8334 8335 8341 8342 8347 55320 8348 8345 201254 51773 55355 11339 387103 8340 54069 23649 8338 5422 85236 8349 5557 4869 5558 1017 2237 1616 8370 546 80119 3013 55164 54921 63922 1060 10856 255626 80169 79075 55166 79991 1058 100134934 79019 3021 3018 3017 3014 23421 474382 57082 8970 128312 64105 55766 401541 8467 378708 79172 91687 5928 79682 80152 2491 23243 26277 25913 64946 5537 3978 55839 55291 890 54386 8290 5440 5441 7013 65057 7014 5434 5435 5436 5437 7486 5438 5981 5439 5982 5983 8900 5430 5431 5432 55135 5433 1736 5111 5931 641 6117 5984 5985 5424 55505 94239 6119 5425 6118 7015 54433 55651 10714 57804 54145 1763 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 96%9824443 Parasitic Infection Pathways 3553 10787 834 8936 718 10152 124056 3071 10163 3606 27035 63916 10006 4791 79792 1793 5879 3552 23191 1432 1398 9844 3055 5594 5595 998 5567 10093 5568 10092 10095 4210 10094 5025 10097 10096 1855 57105 111 10810 112 3162 113 114 115 2268 1857 1856 7454 7456 5747 2678 5027 64174 147179 10910 1511 3710 136 4907 2687 4620 2209 4650 346562 5575 7410 4641 1800 7525 10800 5573 2214 2212 7409 4651 4690 29108 644150 114548 26999 953 10451 5577 5336 4644 5613 79651 957 5576 10769 719 10109 9332 2534 8976 3586 4627 196883 6850 2771 808 2770 695 10552 2781 9051 2773 107 108 10768 71 109 3708 4790 51517 3709 5566 3326 7295 3725 5970 5045 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 94235 3569 55970 5599 10628 60 54331 5335 59345 917 4067 7474 6868 8324 2782 25 2778 10811 1535 10458 10681 55845 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN 5591 11277 51428 340061 3428 197358 4361 29110 147945 3661 23220 7520 2547 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.1 Aggregated β-amyloid induces FXII autocatalysis 2161 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors 3061 347148 10886 8620 64106 3060 84109 3062 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME%R-HSA-2995410.7 Nuclear Envelope (NE) Reassembly 92421 23636 9631 27243 128866 23511 27183 4001 53371 1104 8815 5515 79643 5518 51652 891 7443 983 9798 22933 221496 79902 200014 2010 260334 6683 347688 23141 29082 91782 25978 113457 7341 23592 7280 3930 10376 80086 25909 7329 51807 3842 10381 10383 10382 112714 7846 84790 348995 3837 5520 57122 84617 55746 347733 9133 7277 23279 79023 7278 81027 6396 79861 5901 9883 129401 9688 5905 23165 55706 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing 27350 103 29974 164668 403314 200315 339 9582 10930 104 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD 19 335 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 5395 5424 6119 4436 5425 4437 4292 6118 10714 57804 9156 5111 3978 6117 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception 338328 5406 1208 4023 336 337 3949 344 2652 345 346562 4641 6383 10082 4627 6385 6382 109 221914 9672 3781 2239 57053 3778 3779 2342 2339 3339 129446 2262 25861 161497 124590 51168 11344 64072 4647 53904 494513 9750 2817 259236 65217 23136 339768 117532 117531 25794 283310 643226 340990 286262 375611 4354 10518 5357 53405 2719 10083 64787 222662 83715 9132 3759 389207 2059 140469 2934 2036 1645 1109 8573 375790 2774 6010 2779 6295 1259 1258 9187 10170 8644 9249 157506 5959 56656 8608 120065 121275 51109 120066 283365 285440 5950 390883 390882 390649 5948 390648 5949 124538 388531 283111 5947 4991 4992 5145 4993 5578 442184 442185 442186 5158 79310 5148 79317 284433 5330 57101 341799 5957 219954 219952 121130 79541 79544 121364 125963 125962 4994 79549 4995 283694 121129 133060 219965 130075 219960 390431 390433 442361 390436 390437 390439 341418 79334 341416 79339 219959 219958 219957 219956 283162 138804 65055 138805 283160 138802 138803 390441 390442 390321 390201 390323 390445 390326 390327 144124 254973 144125 79324 10988 283159 7804 219968 127608 219865 6340 219986 219983 219982 390892 219981 401994 401993 401992 6337 285659 6339 1262 81309 6338 79473 1260 81797 390538 145226 7932 219858 219875 219874 219873 219870 390429 79346 79345 26188 81300 26189 50700 219869 347168 26716 286365 283093 283092 347169 138799 390113 3000 134083 391211 392309 54884 150681 338674 338675 340980 283189 219417 219438 219437 219436 64220 26707 9397 219432 219431 126541 338662 403282 403284 79823 127623 254879 283297 255725 219429 284383 219428 126370 219447 390271 390151 390152 391121 441308 390154 54795 390275 390155 441669 390157 390036 390037 611 390038 441670 158131 138882 138883 29850 138881 23538 390162 5475 219453 390167 390168 3292 347468 8630 219469 4035 219464 338751 391107 391109 338755 254786 254783 10798 390260 390261 219479 390142 219477 162998 4836 390264 391112 390144 390265 391114 219473 390148 79501 286362 390072 390195 390075 390197 390077 219487 390199 392376 390078 390079 219484 219482 392138 127385 24 143502 119764 119765 143503 5588 81050 390081 390082 390083 390084 6121 131890 26687 119749 402135 26689 219493 23173 81168 81285 9626 392391 81282 392390 504190 6011 1879 390174 390054 26533 256892 390058 26532 390059 26534 26658 151056 26539 26538 26659 26531 343173 390181 390061 343172 343171 343170 390063 441639 390064 389090 390066 390067 26664 343169 335 6017 81061 390190 338 390191 403274 127062 403277 403278 127069 127068 255022 127066 127064 403273 120787 119687 81099 119682 26529 441933 127059 26648 120775 120776 119678 9355 119679 53630 55937 390093 392392 403253 441608 403257 391189 26735 128371 26737 8590 128372 808 391190 196335 391192 5956 346525 391191 391194 391196 391195 5726 403244 128366 5756 128367 128368 128360 119774 119772 26740 403239 346517 9227 79490 81328 120586 259289 256148 5962 83875 259287 81696 259286 81697 259285 4478 8387 8388 8386 158835 6709 8383 81318 79482 81448 6324 81327 259293 81442 259292 132112 259290 393046 259296 8861 8390 259295 8392 2792 122742 26494 401427 6711 26493 26496 401667 401666 282775 122740 6330 401665 26497 6335 81470 81472 282770 341276 2784 6326 122748 127074 6328 341152 6327 256144 127077 54429 7430 283617 80835 51764 120796 80834 81469 119694 119695 26020 120793 81466 57016 282763 81341 343563 119692 2979 6844 387748 6616 2978 344892 6804 79290 79296 135924 79295 2986 26595 26476 284532 125958 348 442191 26246 442194 26248 442197 81127 5864 26245 80331 284521 119395 6853 135941 29967 26339 26338 135946 26219 135948 121214 26692 402317 26693 26333 26696 9254 26212 81399 26211 783 2914 81392 388761 2782 343406 26341 83756 50831 50833 50832 50834 50837 50836 50839 50838 50840 2911 440699 9381 7276 27445 830 832 8927 9478 776 246213 51475 6855 829 3710 490 55584 4036 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation 63976 4086 7350 1149 3065 83401 23090 4089 1107 1346 53615 1108 57459 5931 9219 8648 10891 54815 133522 3066 6256 5465 5928 57504 655 3192 9112 5468 64641 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%383280 Nuclear Receptor transcription pathway 6097 2516 5914 7182 6096 2063 126382 9975 5915 5916 3164 5467 2100 7067 9611 29959 7068 5241 9572 7376 3174 6256 3172 8431 7421 5465 7101 2099 5469 7181 9612 6095 7025 367 4929 6258 2104 6257 2103 2101 5468 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME DATABASE ID RELEASE 96%936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 7314 7099 929 3665 7187 9641 353376 148022 5781 10010 10133 23643 29110 6233 3661 7316 7311 VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 96%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) 54716 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-HSA-75105.12 Fatty acyl-CoA biosynthesis 11000 54898 5538 197322 83401 51703 6785 22880 9374 2182 3293 81616 2181 51495 60481 7923 109703458 2180 2194 79966 6319 79071 11001 31 9200 47 9524 64834 401494 23205 23305 79993 84869 253017 201562 51144 55301 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME%R-HSA-9709603.2 Impaired BRCA2 binding to PALB2 5888 79728 80010 5889 7486 116028 472 10635 672 675 83990 10111 7516 5932 4361 7156 9156 5890 5892 4683 580 641 10524 1763 ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 96%1482922 Acyl chain remodelling of PI 123745 79887 255189 5319 22925 64600 79143 8399 30814 5320 5322 5321 26279 283748 81579 8605 11145 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 96%1234174 Cellular response to hypoxia 5708 5709 5700 5701 7321 5702 5704 5705 5682 5683 5684 5685 126374 112399 5686 112398 5717 8994 5718 55662 5719 54583 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 6921 5695 9978 7314 7322 6923 7422 5687 5688 5689 2034 64344 2033 7428 10370 3091 7323 84962 25994 2056 8453 768 1387 9861 405 6233 7316 10213 5706 5707 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5676590 NIK-->noncanonical NF-kB signaling 5708 5709 1147 5700 5701 9040 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 4791 5694 9020 7311 5695 7314 6500 5687 5688 5689 5971 9861 8454 6233 7316 10213 5706 23291 9039 5707 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 96%5218900 CASP8 activity is inhibited 841 356 355 8737 8795 7186 8743 8797 8717 8772 RHOA GTPASE CYCLE%REACTOME%R-HSA-8980692.2 RHOA GTPase cycle 9341 70 394 23092 10395 57580 143872 10276 396 5099 26030 9138 397 8086 128239 10211 1729 11214 128272 5337 29 5924 10652 64411 3998 29127 25791 613 81839 22899 50649 8874 2319 8997 7984 116984 57449 55701 23263 5825 1794 4983 3895 57522 708 8987 55789 4162 7112 80728 9217 55200 4168 81624 57514 6811 57636 55219 55914 58504 91452 57569 55852 10144 64333 116985 25963 9912 79822 23526 79658 23779 51291 9824 83478 84317 9411 393 857 4650 7410 89839 65992 7409 10160 25894 55831 10451 93663 10424 117289 84986 6093 8826 343578 50619 257106 114822 80243 9475 23197 23256 10134 3163 9414 3930 537 7074 7037 6793 65124 5585 5586 55160 387 23002 23365 23370 115557 9181 91010 29941 85415 5295 5296 1894 4649 8773 6242 9754 2040 395 3728 54443 9748 9826 11113 7204 90627 9743 64283 2909 9828 284119 57584 50650 9639 392 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665686 Signaling by ERBB2 TMD JMD mutants 2064 1956 4893 6654 3084 3265 3320 55914 9542 5335 10718 145957 6464 685 1950 11140 2069 1839 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME%R-HSA-9022699.2 MECP2 regulates neuronal receptors and channels 5775 3065 3066 5770 2891 25942 114787 2904 2903 2289 6515 4233 4986 4988 7222 ACTIVATION OF PKB%REACTOME%R-HSA-165158.6 Activation of PKB 5170 57761 117145 208 PDGFR MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9674428 PDGFR mutants bind TKIs 5156 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855183 Synthesis of IP2, IP, and Ins in the cytosol 9108 66036 55586 3613 3612 51477 27124 3632 4952 8867 3628 3631 3633 8821 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 96%381426 Regulation of IGF Activity by IGFBP 3912 721 4312 718 10618 1462 813 354 3817 3485 255738 3483 51246 462 54757 8404 8542 29106 5034 3491 3489 3895 3488 1471 3487 64856 10117 3816 116519 1114 258 7857 10232 5768 5954 56955 4240 1758 2621 4241 197 3270 213 3371 265 336 401138 51156 5069 147111 51280 56975 60676 3956 2200 4924 3053 26085 8614 2519 375056 7076 5624 10272 174 5340 2999 80341 54972 4148 3698 2147 1435 84141 9210 11098 54587 4052 6694 334 3481 3479 11320 5611 335 3827 338 1511 4221 7184 5589 6383 4313 2266 2243 351 5265 10130 2153 3490 57719 7425 7466 91851 11167 6696 3569 1356 2719 57104 652 7018 348 1000 5179 3486 3484 102 10970 8074 8720 3913 3915 2335 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex 10980 7874 9318 50813 10920 6917 2873 7507 51138 2074 10987 7311 9978 7314 56949 1161 5440 5441 4331 1022 2071 2966 2965 2068 9716 5434 5435 5436 5437 5438 5439 2968 2967 91603 404672 5430 57654 5431 5432 5433 902 8451 8450 1642 10450 27339 6233 7316 8533 57461 64708 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication 8331 3013 8337 8334 8335 255626 5000 5001 8341 3021 23594 3018 8342 23595 3017 8347 4998 3014 8348 4999 8345 3837 8340 474382 8970 128312 8338 85236 8349 94239 55766 8968 653604 8370 23633 54145 3836 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 96%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 5557 5519 5558 7027 28227 5515 5516 5518 7029 1869 5925 23649 5422 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT 8452 8331 8607 8337 8334 8335 8313 8341 64750 8342 8347 8348 8345 8340 79577 8338 7089 85236 1499 331 8349 123169 7091 59349 2932 23072 8370 7534 6597 3013 3065 255626 9580 27121 79412 64321 3021 1855 83999 3018 2033 343637 3017 6662 1455 3014 27123 9736 83595 11197 10023 50964 474382 9101 1857 8312 54894 1856 8549 6423 6422 8970 6259 128312 6658 6659 7514 23401 8295 83439 55366 55766 284654 857 607 8968 90780 57680 56998 283149 4040 4221 51176 22943 4041 207 59352 208 25776 26108 653604 55553 440193 1387 84661 340419 84133 11091 6736 9861 6233 7316 5929 10213 5706 5707 5708 5709 7090 5519 5700 5701 5702 5704 139285 5705 5682 5683 81847 5515 5684 5516 5685 5518 8658 80351 5686 5717 8395 5718 5719 8945 11047 5713 5714 7979 5525 5690 5526 5691 5692 5527 5693 5528 5694 5529 7311 5695 9978 7314 7483 5687 5688 5689 8290 54361 7088 84870 324 1460 6657 1459 1457 4609 7855 8321 7473 8322 89780 94239 864 9070 7474 8325 1454 7015 1452 8323 7479 7478 1487 7471 2535 54145 6932 10524 6934 9757 SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells 8563 146433 1435 6772 6774 3635 3636 7311 4067 7314 3845 867 9402 6714 6654 1436 7525 5781 5295 5290 139716 3055 5291 5336 5293 6233 7316 6464 2534 9846 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 96%392517 Rap1 signalling 7529 10125 5894 5567 5568 5908 10235 5566 11069 10411 23108 6494 7534 5909 5906 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 1802 1801 92715 89978 51611 285381 120526 1938 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching 8440 6092 6091 6585 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 96%4420097 VEGFA-VEGFR2 Pathway 808 6093 3690 10787 5062 8936 10768 3708 117145 10152 3709 2185 5566 9475 5921 3071 10163 653361 2475 63916 10006 1500 1499 1793 5879 9564 4893 1003 79109 3265 3791 23191 9261 558 1432 1398 9844 25759 6300 998 5600 7867 5603 55615 5567 5568 3320 10810 5335 5580 64223 10000 3685 5747 3315 5578 5829 8440 3710 857 253260 7410 5590 57761 387 207 208 7409 5295 4690 5296 5058 8877 26999 5290 10451 5170 1536 3728 5291 1535 4846 10458 9047 1495 5579 6461 2534 4688 55845 4689 5063 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME%R-HSA-9933947.1 Formation of the non-canonical BAF (ncBAF) complex 6604 6601 6603 26039 6602 86 6760 9274 60 9275 605 23506 6595 65980 6597 29998 6599 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) 3425 REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity 7975 81502 3162 571 4780 FRUCTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70350 Fructose catabolism 229 26007 216 132158 3795 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 96%2132295 MHC class II antigen presentation 55860 51164 10671 8907 130340 93661 10053 84516 7879 1174 8905 162 10437 164 29127 6456 1213 1211 160 161 163 3123 3122 830 832 3120 3119 3118 829 3115 3113 1175 8655 1173 3798 3799 3127 1062 3126 3125 821 51143 1520 5641 1508 6396 1781 22920 1780 1778 81930 84643 3796 1509 10540 64837 1783 26153 147700 1512 1510 10112 1519 8722 9493 10120 3831 3832 3835 83547 140735 972 56992 24137 89953 11004 3112 3111 114876 3902 3109 22872 3108 1759 5476 9371 10121 1075 285643 1639 1514 6712 1513 3797 26052 1515 375 11127 1785 51128 9871 9632 10427 11258 10802 10484 REPRESSION OF WNT TARGET GENES%REACTOME%R-HSA-4641265.5 Repression of WNT target genes 1488 83439 1487 7090 7091 7088 3065 166 51176 6932 6934 7089 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 54898 2180 83401 9415 6342 3992 64834 215 3295 30 10005 60481 HOST INTERACTIONS OF HIV FACTORS%REACTOME%R-HSA-162909.3 Host Interactions of HIV factors 23636 9972 9631 7175 8907 130340 11097 23511 3105 567 8086 8021 10053 5062 1174 53371 8905 8480 1104 10762 162 55690 8815 164 5902 1794 4869 5879 160 161 163 9844 3055 926 1175 1173 348995 3932 3837 57122 55746 7514 23279 79023 6396 5901 9861 6233 7316 10213 2534 5905 5706 5707 5708 5709 5903 5478 5700 5701 5702 5704 5705 5682 5683 5684 5685 1025 5686 5717 5718 5719 8945 11047 5713 79902 5714 7979 5690 5691 5692 5693 5694 7311 6921 5695 9978 7314 6500 6923 5687 5688 904 5689 51606 8065 375 920 9883 129401 9688 291 292 293 940 23225 3836 4927 3159 23165 11168 55706 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins 4048 240 246 3248 RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 96%6802953 RAS signaling downstream of NF1 loss-of-function variants 4763 399473 161742 4893 200734 3265 EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation 6230 6231 6234 9349 6235 6191 8893 6193 1965 8894 6192 8891 6194 8892 1968 8890 51121 1967 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 1974 6133 1973 6132 8662 6135 8663 6134 8661 6137 8666 6136 8667 6232 8664 6128 8665 6129 27335 3646 6142 51386 6141 7458 6144 8668 6143 8669 6146 10480 6147 1964 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 26986 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 6222 6224 6181 6218 6217 1983 9669 7311 1975 1978 1977 1981 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME%R-HSA-168274.5 Export of Viral Ribonucleoproteins from Nucleus 23636 9972 5903 9631 7175 11097 23511 8086 3304 8021 53371 8480 10762 348995 79902 57122 7514 55746 23279 79023 6396 5901 9883 129401 9688 23225 4927 23165 55706 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399719 Trafficking of AMPA receptors 2892 817 2890 818 80852 9463 2893 4646 2891 2036 5578 27092 7102 23426 4193 4905 160 10369 10368 5582 59283 5579 1742 9495 1739 815 816 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor 7450 2157 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 96%6791465 Pentose phosphate pathway disease 6888 22934 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 96%69052 Switching of origins to a post-replicative state 5708 5709 5700 51529 5701 7321 5702 5704 8881 64682 5705 25906 11065 5682 8697 5683 7324 84515 5000 5684 10393 29945 5001 27338 5685 23594 119504 23595 5686 29882 4998 5717 4999 5718 246184 5719 996 11047 51434 5713 51433 4172 5714 4173 7979 4174 5690 4175 5691 4176 5692 5693 5694 7311 4171 5695 9978 7314 6500 890 5687 5688 5689 1017 898 81620 51343 6502 51053 9134 8900 990 9861 8454 6233 7316 10213 5706 5707 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%901042 Calnexin calreticulin cycle 6400 821 91445 6048 55741 80267 10299 10206 56886 2923 267 7844 10956 7311 55757 11236 7314 84447 9695 23193 11253 5589 6233 7316 811 51009 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME%R-HSA-9927418.2 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 374 7039 1950 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis 144233 57510 29102 5434 5435 5436 5437 5438 5439 192669 5430 54487 192670 5901 5431 27161 5432 5433 5440 26523 5441 23405 8575 6895 NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 96%9032759 NTRK2 activates RAC1 1795 5879 627 4915 ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9678110 Attachment and Entry 7415 7113 59272 1514 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema 710 3818 2161 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73857 RNA Polymerase II Transcription 8331 7004 8337 7003 8334 7005 8335 2353 192670 27161 8341 8463 8342 8347 8348 8345 26523 8340 53632 2475 8338 85236 8349 23112 57690 2932 192669 79109 81608 5781 8370 2146 4343 3013 55615 255626 5562 5563 6772 5564 5565 3021 3018 3017 3014 5571 64223 474382 10000 8970 128312 27327 83439 55766 8726 8968 7532 51176 7525 207 208 653604 84661 11091 25937 23512 5928 5929 8178 129685 6872 22916 6874 6873 6908 4686 6827 6749 6881 6880 6883 6882 6884 8148 9150 6917 1025 51497 11198 6875 6878 83860 6877 8812 2959 2958 6879 2957 25920 54457 2961 8189 2960 11051 51224 6921 10978 1479 6924 7936 51692 1478 6923 1477 7469 23283 138474 904 10914 53981 905 51585 29894 55339 7157 23168 79577 80349 7040 10898 123169 9646 54623 142 8106 1998 1997 640 861 5079 865 25925 6657 7222 5588 7534 7533 5443 3065 3815 6662 1081 857 79869 5045 6794 7248 55004 8649 64121 7249 58528 10542 389541 28956 57521 10670 6009 5494 153129 10325 6667 4800 4801 4802 57678 355 834 83737 54205 8795 10273 8797 8626 581 815 816 817 818 5566 8535 79813 7295 648 4194 8550 6015 890 4193 1912 1911 10919 5608 80012 84733 27287 6045 1030 1029 3569 23466 8900 1051 57332 627 2904 28514 182 10419 6628 51808 6634 6636 6635 6637 25946 57060 11200 51230 814 2903 10769 51593 25904 168374 5816 29028 284459 3630 90317 155061 10650 2308 121274 55571 54487 284443 6910 155054 90589 147694 1482 80778 339488 6929 246175 147686 147687 90338 3654 100129842 4986 4988 64065 22869 90576 90333 6940 2100 285349 353355 81856 81857 1490 6938 100131980 79788 283337 4512 4513 4514 22835 3683 1263 2593 114787 80317 146540 84914 84924 57547 2104 57541 2103 2101 55367 3674 835 3676 3678 284252 839 90594 6720 90592 84911 146542 10628 80314 1024 843 604 847 4778 440077 84701 3458 1278 1277 6722 5875 4303 5876 4322 56242 57573 147657 57336 440073 10848 864 57335 50943 6750 3486 3484 23327 199704 632 389114 51123 7832 10013 637 84289 639 10014 11105 162655 146198 117608 405 4336 6515 10025 23309 7862 7621 2177 2176 892 650 51385 171392 7633 7874 148156 3276 23314 665 4298 341947 6830 79943 27125 7626 55840 4300 10001 7625 85403 11335 55677 7627 3280 6790 126375 25942 374900 55762 79973 79733 5457 5458 7638 348327 7652 23774 29079 57711 5467 55778 10224 8738 91875 7422 163732 221785 374928 3066 200845 148103 3064 694 79755 55786 79759 140612 4149 158399 10432 7673 9612 169270 463 79744 9862 6595 6597 619279 6599 6598 30818 728957 94241 84449 117584 84441 7678 117581 8784 7692 7695 7694 5275 7697 7699 163227 163223 79088 84676 28984 84436 84671 8794 54807 8793 8312 163255 23269 59269 54811 55900 54815 5054 9656 9891 8317 11059 80095 9422 10172 9668 201514 84246 51564 94039 23019 115196 50484 23493 51333 9443 7022 7021 9861 9441 9442 8454 126070 6233 7025 7316 26974 5579 65988 10213 25888 9440 23468 5706 7020 728927 5707 23460 5708 51586 5709 23462 10398 9439 5700 10397 5701 10155 5702 286075 5704 1956 5705 4790 7039 5682 126068 5683 374879 127396 5684 2811 2810 5685 51592 55713 5686 10168 9464 5717 114907 5718 84838 5719 2821 11047 26152 26155 5713 163081 5714 9219 7979 5690 374655 5691 9477 5692 7296 5693 7057 5694 112950 57472 7311 7291 5970 5695 57474 91120 7314 6500 7050 169841 5687 83744 5688 163071 83746 5689 83741 390927 147837 1749 8396 7067 7341 7068 1514 5241 204851 1513 7376 84626 6256 7421 80264 5465 1750 29883 3930 2099 1515 7181 26149 6095 63934 367 57492 4929 163087 2908 79027 144348 9021 9759 5468 2625 3958 7329 2624 60436 2623 2516 84883 5914 2626 90075 7486 3726 79047 2877 5982 84874 5983 2874 3364 472 84870 80032 672 113835 93134 199692 84126 144715 163059 83990 23067 5810 9282 2891 28996 5932 92285 92283 9156 256051 5111 11073 5915 5916 641 2645 146713 143686 6117 51741 341359 5984 3977 5985 2648 6119 63970 349075 2660 6118 163049 1327 163051 4839 5883 163050 5884 654254 116028 900 901 51755 340252 1329 1111 30832 65243 83695 285676 4850 10111 1340 79891 4361 3516 4848 7156 2669 5892 1337 4849 4683 79898 580 5933 4602 5934 10524 1763 1339 4605 545 23619 1351 5888 65018 80010 1350 100287226 51529 1349 1107 7321 79885 8881 64682 1347 25906 1346 11065 388536 1345 8697 55215 7324 10393 10308 124411 29945 10781 27338 119504 10780 29882 4852 891 4853 246184 4854 10782 983 4855 996 65251 51434 1108 51433 162966 162967 162963 1121 4233 100289635 22974 388569 83933 388566 1499 388567 4869 388561 9099 5728 284309 6714 125965 284307 284306 400720 58500 10520 4878 10765 3562 55240 3559 1432 27165 3558 1378 147741 27166 253639 5594 7913 5595 10971 5978 5979 284370 115509 90233 5600 29117 57677 3329 22938 79230 7529 339327 339559 146434 26053 124446 353274 6601 6603 6602 6621 6605 158431 6619 57209 7702 5770 6618 10302 91584 2033 7710 6617 57693 387032 613227 27153 6907 27154 57459 133383 7700 7703 4435 10891 219749 10370 5300 7514 220992 51003 10498 5775 79718 7712 6604 442319 7711 4208 79818 10135 10138 266743 4221 148254 4697 8841 9611 51499 5305 23411 5308 9572 90827 1387 7728 2290 23429 1386 7743 5469 148266 148268 406 80818 2289 342926 23660 4773 56950 5451 55869 6886 7733 54778 808 7738 9915 23439 730087 7752 7994 5052 7753 7001 2064 2063 441234 7531 54541 8851 1020 55634 51276 353088 10018 7745 56729 5325 7988 356 995 7748 136051 10127 8850 7761 6648 7760 2309 91975 3725 7762 114026 3164 339500 4004 4488 100129543 7755 4851 4005 317 9978 7757 55888 7770 8861 219578 7771 7773 8621 90874 162972 23410 161882 148213 3174 3172 148203 51058 196528 148206 7767 5105 55659 7766 7769 55657 7768 7528 6696 5366 730291 126231 55663 1392 579 55422 84967 7884 6446 134353 6688 10794 10793 10795 7539 5371 7552 7551 9975 285267 9734 285268 4287 7556 255403 79862 348 9968 9969 7549 57615 90649 100131827 7561 7562 7565 7323 122809 7567 7566 7559 9739 8409 6241 94115 7571 7574 9997 7576 29959 51412 7568 80196 54925 8431 3549 7582 7101 25 7587 6498 7586 6497 6258 6257 7581 84108 9757 8427 7594 4086 7596 4087 4088 4089 9534 8445 7592 126382 84333 199777 53615 9540 7122 2572 64750 2571 4091 23368 4092 4094 85456 197320 84124 54715 5196 9794 9310 6046 9314 64769 25799 1820 440519 440515 54971 9337 162239 7027 7159 1021 181 1019 90809 595 54989 1017 152687 894 55835 896 10046 8239 898 86 8013 51343 79370 6502 8493 7161 1616 170960 9134 57343 1027 57103 1026 125919 147948 7029 147949 9358 1869 5925 170959 26048 55170 90390 80108 80110 221044 9125 6097 342132 285971 7182 6096 144455 1876 4904 1875 1874 26013 282890 344787 9377 8289 92595 55193 1643 27113 80139 168417 1649 2737 1647 2736 79175 133746 93474 2744 84527 387893 84765 58484 57154 83667 3845 133522 9167 121340 58491 58492 1437 1436 147923 27300 59348 147929 340385 8089 112858 8085 84775 3622 2539 2538 5519 332 5515 5516 5518 9212 5527 5395 4436 4292 65123 57508 80789 26173 55726 5452 55756 64859 26512 23248 25896 100506658 80237 79035 79664 29101 7082 22936 81556 55656 5440 79871 5441 23379 8732 54973 4331 92105 8731 55174 1022 57117 2071 55197 6829 84524 2966 58490 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 4297 1460 1459 1457 4609 5931 10413 94239 9070 253260 51422 1493 5170 54145 6932 6934 58508 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9865881 Complex III assembly 7384 7386 440957 7388 440567 2395 7381 728568 55245 10975 57128 4519 27089 29796 3954 90624 84300 617 150274 54902 790955 1537 3313 7385 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 96%5218921 VEGFR2 mediated cell proliferation 808 3710 10768 4893 5590 3708 3709 3791 3265 5921 8877 5170 5335 5580 5579 5578 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9608287 Defective MUTYH substrate binding SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR 10276 9138 727 388 718 11214 128272 26230 29 121512 84904 100271715 25791 89846 6915 54848 22899 50649 5364 8874 64857 2768 57449 389337 445328 2245 221472 55701 10672 9459 146 389 147 148 146850 9287 3363 3362 998 3361 3360 59340 153 2652 154 155 3358 3357 3356 1133 5567 3355 5568 1816 83551 1815 1814 1813 1812 134864 319100 134860 57105 9038 1132 111 3354 1131 112 3352 113 3274 114 3351 115 3350 1129 1128 10000 3269 11255 4935 136 23533 346562 5575 207 10800 208 7409 8503 814 5577 5613 719 196883 2771 2770 695 2781 2773 107 108 109 1901 4986 4988 5332 3678 9630 6000 8787 2550 8786 9628 26960 2767 2769 6750 10645 2776 5582 23229 9568 2774 84254 5924 6010 2779 6288 5533 3838 6753 6347 5578 5330 5331 2780 23236 5573 5579 1956 2847 7222 7225 387 23370 611 57113 7204 57580 1234 4852 26084 3688 8997 6453 7984 23263 6714 4893 5588 4168 6654 10235 27237 3265 6195 5594 5595 1908 1906 5443 4157 11343 1910 5499 4161 4160 4159 1524 7252 1081 6387 7410 51083 7852 729230 10451 1230 10663 1240 56670 338398 1238 5576 1237 1236 6655 1235 5534 1233 1232 808 170589 4985 4987 5530 6093 5956 5532 3792 10125 5729 27198 27199 5726 5739 2587 1020 5732 4886 351 5733 9475 5734 4887 10850 4889 2359 1269 2357 1268 259289 2492 259287 259286 259285 3579 3577 2488 56477 5995 4543 4544 259294 259293 7484 259292 7483 259290 30817 5741 259296 2793 259295 2792 353164 2791 5660 2790 6751 5540 7480 6752 9340 5539 7482 116512 7481 2788 338442 2787 54886 643 796 2786 6755 80326 6754 301 8811 797 2785 151306 163404 116 2784 8843 5697 2740 256933 117 79948 799 2783 7504 54429 6469 80835 51764 80834 94235 3375 10692 1839 1394 9934 1393 5473 54361 4142 1392 8862 55970 51052 9718 113091 79924 4283 10266 6346 5744 4158 5745 5368 10268 10563 5746 6351 10267 6352 6354 50846 90226 6357 2692 6356 2691 6348 6608 6349 5030 133 54331 6361 51384 6364 114131 6363 53829 59345 6366 2642 6367 2641 7855 6360 7976 1903 976 6373 6372 8321 6374 7473 6376 8322 6370 7472 89780 134 135 7475 5173 7474 8325 5179 7433 9890 6344 64748 150 7477 140 151 8326 51554 152 5140 7476 58191 7432 8698 6343 7253 8323 2919 7479 2918 8324 2917 7434 2916 7478 2914 8643 53637 2913 2782 7471 2912 3549 2921 2920 84658 221391 2778 8484 2535 2015 11251 2696 23596 2695 186 7349 187 10681 83756 11211 165140 1604 50831 5727 50833 10203 50832 2826 50835 50834 50837 50836 50839 50838 2834 2833 4295 2832 7200 2831 7201 122876 431704 50840 56413 1880 5031 57007 5032 283869 6003 2841 1909 57486 6004 2853 94233 2852 2798 10803 2797 2859 2796 50865 1907 1889 5028 5196 2861 84432 9034 5029 64805 1902 9283 6375 3972 1241 3973 2693 9290 84109 9294 10874 1325 29933 2532 222545 3627 10887 5724 10886 257313 5731 5737 64407 387129 2911 2358 846 2915 8111 8477 2922 5996 5997 5998 5999 6846 2925 10161 6863 183 185 623 624 4314 10287 1395 56923 6870 8490 2151 23566 2150 2149 2147 6865 2829 2828 6866 6869 353299 885 886 887 2837 347148 9002 57121 338557 5580 5321 3814 156 10911 5137 2840 5153 2846 594857 5136 64106 3827 129521 128674 2867 2865 2864 2863 3710 2862 60675 4922 4923 2869 8620 680 27334 84634 3060 5367 23620 3062 3061 10316 4828 4829 26575 2520 9170 84539 815 816 817 818 5519 10768 3708 3709 5515 5566 408 6197 5516 409 6196 5518 5528 5020 551 5021 552 553 554 5598 27202 3576 5581 5583 7074 9162 8527 26090 728 8525 8526 57406 221955 10636 160851 10888 1609 26086 747 10846 1608 50940 1607 84152 1606 85397 139189 8601 126006 51289 3640 8622 10022 5141 122042 5143 5144 117579 5138 6019 339403 5139 5151 59350 6001 6002 5150 53831 9560 55160 11245 23365 11250 115557 285601 9181 26166 5294 2838 5295 157 2843 5296 2848 1894 5058 29899 27115 5290 2854 5170 2850 2870 63940 9826 9828 50650 9639 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 96%5579031 Defective ACTH causes obesity and POMCD 5443 4158 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 96%2426168 Activation of gene expression by SREBF (SREBP) 96764 2194 2224 2222 3157 6907 6667 80205 4800 4801 8648 4802 6309 10654 57678 10499 10498 6713 79718 6319 6604 4597 79071 1595 6721 1717 31 32 9453 4047 4520 6256 1387 3422 5465 23054 4598 5469 7108 85441 NUCLEOTIDE CATABOLISM DEFECTS%REACTOME%R-HSA-9735786.3 Nucleotide catabolism defects 4860 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 64135 1147 89122 3551 23586 8517 84282 57506 843 841 8737 7706 8772 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.2 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 8331 8337 8334 8335 10001 1050 8341 8342 8347 8348 8345 8340 79611 51129 8338 29079 85236 8349 4023 8370 9612 5925 9862 84649 90390 7403 3013 2167 948 11343 255626 3991 23175 3021 3018 2033 3017 5346 3014 6907 474382 8648 8970 10891 128312 22976 51003 10499 84962 55766 79718 8968 79447 133522 84246 8841 9611 23411 653604 1387 84661 9443 23054 11091 8085 5469 9442 5929 9440 8202 9439 2494 1020 9477 6256 10555 57104 8800 2874 729359 60481 1024 7069 63924 9282 2180 9968 9969 9370 22822 57678 94239 9070 6319 5166 25 54145 10025 123 58508 892 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%2408522 Selenoamino acid metabolism 875 3176 1491 6230 6231 6234 9349 6235 6191 6193 6192 6194 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 51520 3921 1615 4736 6130 5859 6133 6132 4141 6135 6134 6137 6136 3376 6232 6128 7965 6129 9521 6142 6141 6144 6143 6146 6147 6139 5917 6138 6152 6155 3735 6154 9255 6157 6156 6159 9061 6158 9060 2197 23521 140032 2058 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 6222 6224 6181 6218 6217 7296 7311 4143 191 4837 11185 118672 22928 51091 51540 6301 27232 60678 79048 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins 240 246 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 96%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) 153201 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway 7086 5634 729020 23729 5631 6888 25796 55276 2539 64080 221823 22934 51071 5226 6120 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated 1499 5519 1452 139285 2932 5515 324 5516 5518 8312 5525 5526 5527 5528 5529 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis 6400 5708 5709 5700 5701 5702 5704 5705 10613 5682 5683 5684 5685 5686 5717 5718 5719 91445 6048 11047 5713 5714 7979 5690 5691 5692 91319 5693 5694 10956 7311 5695 7314 11160 5687 5688 5689 7415 27248 9861 1080 6233 79139 7316 10213 5706 51009 5707 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 96%159418 Recycling of bile acids and salts 9971 6555 10599 6554 10499 200931 123264 10998 80765 28234 6579 6256 570 213 8647 2172 8714 8648 SIGNALING BY RAS MUTANTS%REACTOME%R-HSA-6802949.5 Signaling by RAS mutants 808 10256 817 54518 818 8826 22866 7529 7450 3690 5604 5894 5605 5037 2243 7094 5908 369 283455 408 409 3845 6714 4893 3265 673 4140 5594 4296 5595 8315 2335 5245 3717 2244 1445 2266 5906 7414 815 3674 8844 816 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME DATABASE ID RELEASE 96%5218920 VEGFR2 mediated vascular permeability 808 55615 5062 117145 3320 64223 10000 2475 1500 1499 5879 857 253260 57761 7410 1003 79109 207 208 7409 5058 10451 5170 3728 4846 1495 5063 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5607761 Dectin-1 mediated noncanonical NF-kB signaling 5708 5709 1147 5700 5701 9040 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 4791 5694 9020 7311 5970 5695 7314 6500 5687 5688 5689 5971 9861 8454 6233 7316 10213 5706 23291 9039 5707 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013149 RAC1 GTPase cycle 9341 55971 394 23092 10395 57580 143872 396 347902 26030 4810 55619 397 10787 128239 80005 8936 5062 7879 128272 5337 26230 10152 29 10298 5924 10652 84904 64411 124056 29127 25791 9710 613 81839 51347 10788 22899 3071 50649 10163 28964 3688 8874 64857 653361 8997 85440 23075 7984 116984 2010 27035 55114 23344 143098 10006 10672 23263 9459 1794 1793 4983 5879 23380 3895 57522 55789 9901 4162 7112 80728 55200 4168 6654 9732 23616 23191 115703 81624 139818 23592 201176 11135 57514 6510 57636 1969 55914 58504 1124 1123 998 57679 57569 57572 752 10144 64333 116985 9912 23526 10810 9938 79658 51291 83478 7454 7456 27 51306 147179 9411 94134 393 857 4650 23348 7410 23580 84144 7409 10160 25894 56924 644150 8503 26999 10928 10451 6655 8976 57480 57144 117289 8826 50619 221178 257106 152273 80243 55004 3930 5338 9855 7074 7037 1795 182 5585 5586 23370 115557 11188 50855 5295 5296 1894 5058 8773 8476 5290 50508 81704 1536 10811 1535 10458 9826 7444 55843 11113 7204 10979 9743 9815 4688 2909 55845 57584 4689 9639 5063 392 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 96%5579013 Defective CYP7B1 causes SPG5A and CBAS3 9420 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69275 G2 M Transition 51400 51451 90381 79596 728642 63943 984 79866 51512 6790 55320 891 983 55355 5347 9088 22974 85378 10426 29922 27229 440145 1017 80097 55835 114791 10133 27175 2305 653784 51343 10844 7465 286826 132660 1026 91750 55957 8655 1063 151648 10142 23332 5500 2033 22919 3320 5048 5520 7840 11064 7514 22994 9133 22995 84962 7283 203068 55722 1453 54820 7532 9738 11190 28227 1781 95681 1778 1069 9861 5577 8454 6233 7316 54801 9793 10540 5928 10213 4218 5706 23291 5707 5708 11116 5709 5519 5700 5701 5702 5704 5705 54930 7531 5682 5683 5566 5515 5684 79959 5516 993 5685 5518 994 5686 995 5717 93323 3326 5718 5719 8945 22981 11047 5713 5714 7979 80254 5690 55755 5691 10806 5692 5693 5694 10121 7311 5695 9978 7314 80028 6500 9662 890 5687 5688 5689 10733 80321 55125 9814 4331 1022 115106 79441 9702 5108 55142 10383 22897 8900 10382 5116 80184 23194 902 7846 23354 8481 22822 121441 7277 7157 55559 1454 3161 8636 4751 11258 84131 4957 4659 4605 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs 22916 84967 6634 4686 6636 134353 6635 6637 25888 6628 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 96%5663220 RHO GTPases Activate Formins 388 1729 286205 3688 5347 57591 389 5879 23380 81624 54908 114793 6232 998 8655 25909 8379 9183 1063 1062 752 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 1855 81565 22919 348995 348235 5048 23421 57122 1857 220134 1856 57082 57405 147841 51143 6249 55746 7514 4085 64105 401541 23279 79023 10403 54820 80776 701 54821 51466 6396 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 5216 5903 5217 2491 5519 332 55143 699 11243 71 29984 140735 3619 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 79902 5525 5526 55839 5527 5528 5529 60 6722 387 23002 91010 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B 7314 51529 7321 991 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 996 51434 6233 51433 7316 7311 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 96%8978934 Metabolism of cofactors 808 3417 6697 57107 56997 3320 56910 2644 2643 84842 79934 51004 51805 57017 5805 23590 10229 27235 51117 84274 5593 48 207 1719 4846 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 96%9635486 Infection with Mycobacterium tuberculosis 567 7879 4057 7097 5987 3837 2931 9146 5868 11151 57674 7311 1511 7314 4843 26276 2023 51606 6421 4360 5230 6233 5594 7316 5595 3836 80824 PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576890 Phase 3 - rapid repolarisation 23704 9992 3784 23630 3753 3741 10142 3757 10008 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion 5879 5361 5362 3984 5062 55558 91584 5058 3320 3326 10371 1072 8829 2242 2534 5063 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190372 FGFR3c ligand binding and activation 2249 2247 2246 2591 8823 2254 8817 26281 8074 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 96%195258 RHO GTPase Effectors 8331 2017 8337 8334 388 10787 8335 128239 1729 5062 8936 10152 286205 124056 8341 8342 10788 8347 8348 3071 8345 10163 3688 653361 8340 5347 27035 23081 354 3817 10006 8338 85236 389 1499 8349 5879 3895 999 4771 54763 30851 9055 23191 81624 5880 1432 6279 6280 8370 1072 5594 5595 7534 10971 7533 114793 998 5600 3013 752 7529 255626 10093 10092 10095 10094 10097 10096 3021 5500 1855 3018 3017 3014 10810 474382 1857 1856 7454 2316 7456 5747 8970 128312 5300 7514 147179 10499 55766 8968 7532 51466 4221 653604 4690 644150 26999 9928 1495 23028 10109 8976 4627 57120 808 5216 695 6093 5217 10552 71 114822 29984 7531 51517 9475 995 4629 103910 4637 4638 60 6722 5289 91010 25 30849 1742 64130 4628 79784 3984 3985 57591 23380 1027 54908 6232 8655 25909 3798 3799 8379 9183 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 348995 348235 5580 5048 23421 57122 220134 57082 57405 147841 51143 6249 5578 55746 4085 64105 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 5579 57551 79682 5905 64837 1783 5501 147700 83540 80152 5903 2491 8826 5519 10398 332 55143 3831 699 11243 140735 3619 5515 89953 11004 5516 2810 5518 9212 25936 11130 64946 79980 10726 79902 5525 5526 55839 5527 5528 5529 367 94239 5585 5586 5590 387 23002 29941 85415 5058 6242 50508 5170 1536 10811 54145 1080 1535 10458 11113 4660 4688 391 94274 55845 4659 4689 5063 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 96%2046106 alpha-linolenic acid (ALA) metabolism 54898 2180 83401 9415 6342 3992 64834 215 3295 30 10005 60481 TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation 7077 23385 7076 51107 7049 5663 5664 4323 55851 83464 4325 TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism 150379 2167 8228 857 11343 646486 3991 5567 5499 5568 646480 5566 51099 5500 5346 10226 2173 2172 2171 2170 2820 2169 5501 2168 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) 948 1536 653361 1535 3685 4688 3693 4689 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 96%177504 Retrograde neurotrophin signalling 1213 1211 160 161 163 10126 26052 1759 4803 1785 6456 1175 4914 1173 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 7022 284252 7021 339488 79047 83741 7341 51741 7020 7329 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-HSA-9006931.7 Signaling by Nuclear Receptors 8331 8337 8334 8335 2353 192670 27161 8341 8342 8347 8348 8345 26523 8340 27329 2354 8338 9619 85236 10062 8349 23112 19 6714 57690 340481 1071 4893 1382 192669 858 4316 10901 3265 54659 29116 55625 5481 8370 2172 5594 2171 5595 341 4343 344 3013 346 3065 255626 3021 3018 2033 3017 5346 3014 4318 3480 6907 474382 10000 8648 5747 4435 8970 128312 5536 27327 7514 10499 10498 55766 6387 857 79718 8968 346562 3727 8204 8841 207 9682 208 9611 80820 653604 221656 347 1387 10123 55818 8503 1386 5469 51523 1105 2289 1509 23028 4313 2288 5451 8202 23030 7764 2771 808 1655 2770 7090 3169 9166 6908 9687 23189 2773 2494 7033 7392 7391 7031 10728 1025 3326 8850 2309 2958 3725 2957 2100 2793 904 2792 2791 2790 2788 2787 2786 2785 2784 5105 685 127933 2783 255324 51764 2069 7528 94235 2002 1839 55970 54331 6722 59345 348 6667 1903 57678 6319 5162 5163 5164 5165 2782 8877 5166 8050 6258 6257 5160 10681 5161 1737 3276 216 5467 595 200845 124 126 127 1027 9612 112724 10170 4314 8644 9249 8854 64577 1592 157506 1381 220 5959 195814 57665 56603 8608 340665 51109 3320 64241 64240 9126 3838 8312 6801 10735 4846 1956 10274 7039 861 865 8243 2194 5885 5241 7376 6256 2099 5440 5441 2625 2963 2962 5434 5914 5435 5436 5437 5438 5439 2874 5430 5431 5432 5433 4609 374 5915 596 5916 1950 94239 5590 1738 5295 5296 5290 5170 54145 4602 10524 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%1839124 FGFR1 mutant receptor activation 11116 8805 9208 6772 6774 613 2260 11160 399687 11052 26127 2254 1523 2251 8074 5295 2249 6777 6776 2247 2246 5290 9846 9530 26281 7750 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 51750 5888 80010 5889 7486 472 672 675 83990 7516 5932 7517 9156 7979 641 79728 116028 10635 10111 4361 7156 5890 5892 4683 580 10524 1763 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes 91522 1297 1296 1295 1294 1293 283208 1292 1291 1290 1305 1303 1302 1301 1289 1300 1288 1287 85301 1308 1307 84570 1306 5034 10491 23127 10536 871 5351 5352 8985 55214 64175 26577 5118 79709 1278 1277 8974 140766 9508 9509 7093 5479 7092 649 50509 5033 1286 1285 256076 1284 1282 1281 169044 1280 81578 80781 255631 1299 1310 57642 1298 340267 7373 131873 136227 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection 8907 130340 3105 567 10053 5062 1174 8905 1104 162 55690 1234 164 5902 4836 1794 4869 5879 160 161 163 9844 3055 926 1175 1173 3932 7514 7518 3981 7852 2534 8178 129685 6872 22916 5478 6874 6873 6908 4686 6827 6749 6881 6880 6883 6882 6884 8148 9150 6917 1025 51497 11198 6875 6878 83860 6877 8812 3978 2959 2958 6879 2957 25920 54457 2961 2960 51224 6921 9978 6924 5045 7936 6923 7469 138474 904 905 375 23327 9883 129401 9688 291 292 293 23225 3836 4927 3159 23165 11168 55706 92421 23636 9972 9631 27243 7175 11097 128866 23511 8086 8021 10015 53371 8480 10762 8815 79643 51652 29082 91782 25978 2237 348995 3837 57122 55746 23279 79023 6396 5901 9861 6233 7316 10213 7520 5905 5706 2547 9525 5707 51160 5708 55048 5709 89853 5903 5700 155382 5701 137492 5702 27183 5704 93343 5705 7251 51271 5682 79720 5683 51510 51534 5684 5685 5686 5717 5718 5719 8945 11047 5713 79902 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 6500 5687 5688 5689 51606 5440 5441 8732 4331 8731 1022 2071 6829 2966 2965 2963 2962 2068 8065 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 9397 920 940 DRUG RESISTANCE OF ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9700649 Drug resistance of ALK mutants 238 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID 1147 3551 8517 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 96%187024 NGF-independant TRKA activation 135 116 117 4914 4915 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling 9965 4893 6654 2254 3265 5781 2251 8074 2249 2247 10817 2246 152831 8823 2264 10818 8817 26281 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism 5019 64064 38 622 NUCLEOTIDE METABOLISM%REACTOME%R-HSA-15869.7 Nucleotide metabolism 25961 79077 1635 2745 56474 102157402 6240 25939 51727 122481 1503 1841 203 204 221264 7295 26289 205 4832 4833 10201 158067 7296 56985 131870 11164 56953 7378 1807 151531 1890 1806 51733 84618 7084 64902 93034 30833 9583 471 790 158 159 954 955 956 9615 5471 161823 5198 4860 270 8226 271 377841 272 7372 51292 7371 83549 132 54963 100 353 22978 10591 2766 57089 1633 122622 1716 978 1723 3704 10606 2618 4907 6241 7498 7298 55270 7083 3251 50484 3615 3614 2987 953 4830 4831 8833 957 CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation 6230 6231 6234 9349 2475 6235 6191 6193 1965 8894 6192 6194 1968 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 1649 8131 64223 201163 55846 23334 6164 440275 6166 144577 6165 23677 6168 84219 6201 10641 6167 81929 55364 6203 652968 6169 96459 6202 83667 116832 729438 6160 79726 6161 10985 154743 9681 57600 54468 6396 11133 27244 6175 9045 6210 6176 6171 6170 6173 1386 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 467 6223 6189 6222 468 6224 6181 6218 6217 440 7311 1054 245972 245973 55004 8649 155066 9114 51606 9550 64121 523 58528 10542 525 389541 526 28956 527 57521 528 10670 529 6009 8992 153129 90423 127124 10325 51382 533 534 10312 1051 9296 57761 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%140534 Ligand-dependent caspase activation 355 7099 929 353376 8743 148022 8717 841 356 8737 23643 8795 7186 8797 8772 RUNX3 REGULATES NOTCH SIGNALING%REACTOME DATABASE ID RELEASE 96%8941856 RUNX3 regulates NOTCH signaling 2648 864 4851 22938 182 84441 10046 3280 2033 1387 8850 3516 9794 HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963896 HDL assembly 29801 19 5567 5568 335 2 5566 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters 115584 114134 6526 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism 93010 79369 10402 10678 5549 2588 8534 8703 8704 9435 8702 112937 4166 3074 4969 3073 79411 2720 4958 6483 6482 6484 2683 6487 176 89944 4060 10331 2799 9334 11041 9331 2331 11046 9469 23563 11081 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 96%9937008 Mitochondrial mRNA modification 51001 81892 55149 55006 84881 285367 22868 26995 51335 81554 10128 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins 4048 240 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%156580 Phase II - Conjugation of compounds 84836 6819 27284 124975 445329 2686 27233 6799 4257 50512 4258 6822 4259 10327 54659 373156 2678 2687 2940 7172 2950 2944 23169 10 2729 9 10941 11046 2730 2939 133688 54490 79799 55347 2938 54658 54657 7358 7363 7365 7364 7367 7366 54600 54578 54577 79094 54576 26873 54575 7360 2098 574537 653689 54579 27306 167127 2941 10720 79017 55748 2949 2948 2947 8460 2946 221357 2954 2953 2952 494143 119391 8459 1544 116285 348158 80146 4143 4144 4552 9446 191 4837 1312 29104 27430 57412 51504 4548 10249 123876 341392 219970 92292 54988 389396 2937 54928 6783 10380 391365 25830 6818 6817 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%R-HSA-3656535.3 TGFBR1 LBD Mutants in Cancer 7046 7048 7040 2280 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%9690406 Transcriptional regulation of testis differentiation 6662 2516 6736 7490 2626 268 2254 1761 5730 50846 23414 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-HSA-110313.3 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 55666 54107 5981 5982 5983 56655 9100 5980 83932 10459 7706 11201 7353 51455 9768 124739 9246 5111 7318 6117 5984 7311 5985 5424 6119 7314 5425 6118 5426 5427 5429 10714 7415 25898 51426 57804 6233 7316 9636 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME DATABASE ID RELEASE 96%5336415 Uptake and function of diphtheria toxin 3320 3326 928 7296 1938 1839 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702998 linifanib-resistant FLT3 mutants 2322 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 96%964739 N-glycan trimming and elongation in the cis-Golgi 4121 10905 4245 79694 57134 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 96%9014826 Interleukin-36 pathway 84639 27177 8808 26525 56300 27179 PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 96%2160456 Phenylketonuria 5053 SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 96%1483191 Synthesis of PC 64900 79888 23175 56910 590 1460 1459 1103 1457 43 10390 9468 1120 126969 162466 204962 10809 80736 56994 1119 57153 5130 23446 84879 171586 58488 10400 9663 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190377 FGFR2b ligand binding and activation 2248 2247 2246 2255 9982 2252 143282 83888 27006 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9931269.1 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 5708 5709 5700 5701 5702 5704 5705 10613 5682 5683 5684 5685 5686 5717 5718 91445 5719 6048 11047 5713 5714 53632 7979 5690 5691 91319 5692 5693 5694 10956 7311 5695 7314 5687 5688 5689 27248 79139 51009 6400 5562 5563 5564 5565 5571 11160 29126 51422 7415 9861 6233 7316 10213 5706 5707 UNCOATING OF THE HIV VIRION%REACTOME%R-HSA-162585.3 Uncoating of the HIV Virion 5478 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) 4056 2948 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 96%4793953 Defective B4GALT1 causes CDG-2d 2683 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 96%5099900 WNT5A-dependent internalization of FZD4 7474 1213 1211 160 161 163 1212 409 5582 5579 1856 1175 1173 8322 5578 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8939902.4 Regulation of RUNX2 expression and activity 5708 650 5709 5700 5701 5702 5704 5705 5682 5683 865 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 10273 5692 5693 4488 5694 7311 7291 5695 9978 7314 6500 5687 5688 2932 5689 1749 6502 1750 2099 2908 2101 579 6772 59269 10891 57154 11059 133522 9861 8454 6233 7316 10213 5706 5707 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF 729238 PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME DATABASE ID RELEASE 96%9636383 Prevention of phagosomal-lysosomal fusion 7314 26276 6233 7316 7879 9146 5868 11151 7311 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 96%194306 Neuropilin interactions with VEGF and VEGFR 8828 2321 8829 3791 ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation 808 857 23576 114757 340481 80777 10434 207 4836 6697 3320 9397 4846 TNF SIGNALING%REACTOME%R-HSA-75893.10 TNF signaling 1147 7132 7321 7332 841 8737 329 7186 10273 7311 330 331 7314 7322 3551 9099 27005 10454 220213 7185 8517 56957 7375 84888 9641 55072 8408 25999 81858 1540 90268 257397 9261 9825 6610 8717 10133 7128 8887 23118 55512 8439 56928 10399 10616 29110 7323 6868 142678 6233 7316 6885 7124 9530 8772 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing 808 5593 3845 4893 5588 10434 3265 51114 402 9986 377630 81926 58489 5147 51104 2342 51125 2339 598 23463 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 96%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) 3566 1107 2353 79885 6778 53615 8535 4853 4094 8850 1108 9219 9794 3725 648 83933 4851 6015 6304 1912 1911 3066 5452 10046 3565 80012 3596 84733 9612 6045 51621 57504 6597 7528 9759 2625 9112 22938 2113 3065 84441 23466 3662 57332 9734 2033 4297 6907 57459 5931 54815 2648 9070 79718 4221 51564 8841 10013 3567 9611 6777 10014 1387 84661 6776 11091 3516 10538 5928 5929 4773 55869 5451 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190374 FGFR1c and Klotho ligand binding and activation 8074 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-HSA-3065679.3 SUMO is proteolytically processed 6613 205564 6612 7341 59343 29843 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 96%8877627 Vitamin E transport 7274 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9617828 FOXO-mediated transcription of cell cycle genes 4087 2660 857 4088 4089 57060 2308 901 694 2290 1027 1026 4303 2309 1647 9314 5934 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation 79587 51067 55699 124454 23395 27068 57038 92935 10352 54938 57505 2617 3735 5859 23438 57176 25973 55157 80222 10667 79731 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9648895 Response of EIF2AK1 (HRI) to heme deficiency 8894 468 1968 79094 1054 57761 1051 27102 22809 23645 1649 2887 440 467 1965 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 96%9930044 Nuclear RNA decay 22916 4686 22803 64895 5393 11340 23144 22894 1797 124245 23016 54439 11044 23404 91746 10179 84186 51010 54512 23211 64848 51013 56915 55596 196441 118460 64062 64282 80335 8106 5394 10438 23517 10200 51593 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 96%195399 VEGF binds to VEGFR leading to receptor dimerization 2324 7423 7422 2321 2277 3791 5228 7424 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 96%432142 Platelet sensitization by LDL 5519 5515 5781 5516 5518 1432 5321 2268 5525 5175 5526 7804 338 5527 5777 5528 5529 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME%R-HSA-9843970.1 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 8331 3013 8337 8334 8335 22880 255626 55729 8341 3021 3018 8342 3017 8347 3014 8348 79813 8345 10179 8340 474382 55596 9869 8970 128312 23272 8338 51535 85236 8349 94239 55766 8968 10919 653604 8370 23517 54737 54145 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%372708 p130Cas linkage to MAPK signaling for integrins 54518 7450 3690 9564 6714 2243 7094 5908 1398 2335 2244 5747 5906 2266 3674 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion 948 2182 2181 MEIOTIC RECOMBINATION%REACTOME%R-HSA-912446.7 Meiotic recombination 8331 8337 5888 8334 5889 8335 8341 8342 8347 8348 8345 8340 8338 85236 8349 4292 1019 1017 8370 8290 3013 255626 472 672 675 56979 3021 3018 3017 3014 5932 474382 641 55732 8970 128312 6117 11144 23626 94239 6119 29893 55766 27030 84057 6118 4438 8968 4439 653604 10111 4361 7156 54145 4683 63979 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME DATABASE ID RELEASE 96%9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK 1460 1457 406 9575 1020 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin 10272 4087 3624 4088 3623 4089 8928 10468 10589 130399 91 93 3625 5594 5595 7049 92 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 96%264876 Insulin processing 23265 64924 57393 3800 3630 5122 25924 1363 6844 60412 6804 54536 5873 169026 5126 56605 10640 11336 5034 149371 55763 4644 3798 55770 3799 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors 3358 3354 3357 3356 3352 3355 3351 3350 3363 3362 3361 3360 DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 96%9734779 Developmental Cell Lineages of the Integumentary System 374 7039 2255 1950 5617 ECM PROTEOGLYCANS%REACTOME%R-HSA-3000178.6 ECM proteoglycans 3910 3911 1297 3912 3673 3690 3679 1462 3688 63827 1634 3680 7040 633 1463 176 3339 3693 1758 3371 3687 3381 7042 1311 4684 3674 4148 7043 6678 3694 8516 3685 5054 4060 5802 54829 8785 4146 7143 4593 1605 7148 2331 63923 1834 1404 4038 3913 3915 1299 284217 1298 3908 375790 3909 7448 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters 79751 6532 83733 9152 55117 6529 6531 11254 6540 6538 57084 57030 6534 246213 6536 340024 6582 140679 6580 6530 54716 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 96%5579000 Defective CYP1B1 causes Glaucoma 1545 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 96%8941237 Invadopodia formation 8751 8728 8038 9644 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654719 SHC-mediated cascade:FGFR4 9965 4893 6654 2254 3265 2251 8074 2249 2247 2246 152831 8823 2264 8817 26281 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%381070 IRE1alpha activates chaperones 51726 7094 118 10130 58477 22872 6745 10897 10525 2081 9797 4189 5526 2673 10106 1663 7466 3068 55062 10954 1639 9695 30827 116138 7709 56005 27230 55033 9114 1200 2134 10113 6734 2137 64061 2135 11015 9820 9570 3309 6464 37 100137049 4000 2931 5611 55738 84447 6818 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI 6119 7314 6118 5981 5982 5983 5980 10459 11201 51455 5111 6233 7316 6117 5984 7311 5985 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73728 RNA Polymerase I Promoter Opening 8331 3013 8337 8334 8932 8335 255626 8341 3021 3018 8342 3017 8347 3014 8348 8345 8340 474382 8970 7343 128312 8338 85236 8349 94239 55766 8968 653604 8370 54145 5595 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%9006925 Intracellular signaling by second messengers 1107 117145 192670 27161 90865 5155 26523 1108 2475 4233 5879 23112 5156 5728 9173 6714 57690 2932 192669 7189 79109 5781 6591 5880 146850 5594 5595 5978 2146 10818 4343 3065 55615 3815 5567 5568 111 112 3932 113 114 115 64223 57459 10000 27327 8726 23533 5575 8841 207 208 5305 7409 8503 1386 814 5577 23512 5613 5928 23028 5576 2534 196883 6615 808 3630 107 2064 108 109 2308 11060 8975 81847 80243 23252 5987 8658 80351 2444 23186 2309 3725 3654 3164 2100 55004 8649 64121 7249 58528 10542 389541 28956 57521 685 10670 6009 255324 2069 153129 1839 84335 10325 6446 3084 5371 4303 26960 572 842 7157 9965 2254 10645 2252 2251 27006 8074 2249 2248 10014 5582 2247 2246 7101 152831 8823 8660 23035 2264 1822 2255 84232 23239 9846 3667 6199 8817 8870 26281 7874 84254 53615 23608 118788 5159 50852 4916 10273 4615 331 3066 51135 4734 1027 1026 2323 2322 57504 9112 2122 5580 3838 156 2931 5137 5153 5136 5578 54815 3710 51564 5573 6801 9861 6233 7316 3643 10213 5706 815 5707 816 5708 817 5709 818 1147 5519 5700 5701 5702 5704 5705 10768 1956 7039 3708 5682 3709 5683 5515 5566 5684 5516 8535 5518 5685 5686 8394 5717 5718 8395 5719 11047 5713 5714 5525 9219 7979 5526 5690 5691 5527 5692 5528 5693 5529 648 5694 7311 5695 6015 7314 5687 4193 5688 1912 1911 5689 8396 80012 84733 2099 6045 5468 930 23466 5581 57332 4915 4908 9542 4909 5335 1460 10718 627 1459 145957 1457 2549 374 5931 1950 1958 3082 253260 57761 23396 5294 5295 5296 5290 5170 5291 5293 57167 940 941 942 391 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 96%8982491 Glycogen metabolism 808 7957 7360 5261 5236 5260 2548 5255 5256 5257 5507 83592 7311 7314 178 8908 378884 6233 5834 2998 7316 5836 2997 5837 2632 2992 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674403 Regorafenib-resistant PDGFR mutants 5156 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation 1029 5519 117584 7874 6446 55615 8900 472 5515 5516 5518 983 64223 10000 2475 5527 7311 4194 7314 7157 9099 890 4193 253260 1017 11200 51230 900 79109 207 208 639 80196 1616 5170 6233 7316 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME%R-HSA-9937080.2 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 2249 2247 2255 1950 2252 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 96%70263 Gluconeogenesis 54020 92579 230 2821 2597 2542 26330 57818 226 387712 229 5223 5224 2023 5091 5232 2203 5230 8789 7167 5105 2538 2027 5106 2026 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades 5062 192670 27161 5155 983 26523 8997 4233 5879 23112 5156 6714 57690 4893 192669 5588 6654 3265 115727 5781 3562 673 3559 3558 4140 25759 5594 5595 6300 6464 5979 10818 998 5906 4343 53358 10602 5900 7529 5604 3815 5605 5567 5568 5500 10435 51125 5747 5536 27327 7514 3716 148170 51114 88 1740 2906 4747 2902 2534 25780 1445 8202 808 10125 3718 2064 7297 2308 2309 2342 3561 3725 2339 6708 6709 9978 10434 51332 6711 6710 8649 6712 9986 377630 81926 58489 51104 28956 80824 685 255324 4684 2069 3674 1839 57731 10048 3084 402 3315 9965 1852 2254 152559 2252 1850 2251 11221 5774 27006 1844 8074 2249 1843 2248 1847 2247 2246 152831 8823 8660 2264 2255 1742 3667 1741 1739 8817 23179 26281 8555 8682 8452 10642 9462 221002 4763 7010 64926 284 84078 2118 8831 5863 399473 22808 10156 161742 9693 3570 989 200734 22821 54756 5923 2676 153090 8036 5924 2675 8437 84292 57139 5921 5596 5922 5623 5597 5159 64096 5786 896 4902 2323 2322 9048 5778 1849 1848 1846 5593 3845 3563 3560 1437 1439 1438 3568 3567 9861 6233 3337 4296 7316 8315 5245 3717 10213 2244 5706 2266 815 5501 7414 5707 816 8844 5708 817 10256 5709 818 54518 8826 22866 5519 7450 5700 5701 3690 5702 5894 5037 5704 5705 2243 1956 7039 7094 5682 5908 369 5683 283455 5515 5566 408 5684 5516 409 5518 5685 5686 5717 5718 5719 11047 5713 5714 5525 7979 5526 5690 5691 5527 5692 5528 5693 5529 5694 23463 7311 8550 5695 7314 5687 5688 5689 5896 5897 3569 2668 10817 9542 2674 10718 145957 2904 4609 374 1950 598 3082 5295 5296 5058 8556 5290 5291 5147 2335 5063 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 96%9769740 Coagulation pathway 6382 7450 3818 5657 3690 2161 2155 2243 2152 351 221914 2811 9672 5197 7056 2153 2165 2160 2239 5270 2159 5104 2158 10544 6609 5196 196527 8858 57126 462 3339 2157 2262 51156 2162 2817 5627 3053 3674 5624 710 2149 2719 2147 2812 203859 3827 2815 2814 5054 11093 6383 2244 10082 2266 6385 375790 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619483 Activation of AMPK downstream of NMDARs 808 5571 5562 53632 5563 10645 5564 51422 5565 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 4067 5519 7525 207 5515 5781 208 5516 5518 1493 3932 5525 941 10000 5526 2534 942 5527 5528 5529 SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 96%1483226 Synthesis of PI 9600 1040 57605 83394 10423 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 96%5693537 Resolution of D-Loop Structures 51750 5888 80010 5889 348654 7486 472 672 675 83990 7516 5932 7517 9156 7979 80198 641 55732 79008 79728 116028 10635 146956 197342 84464 10111 4361 7156 5890 5892 4683 580 23514 63979 10524 1763 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency 26275 INTEGRATION OF PROVIRUS%REACTOME%R-HSA-162592.5 Integration of provirus 5478 7518 3836 8815 7520 3159 3981 2547 11168 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS 6439 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190373.6 FGFR1c ligand binding and activation 2249 2247 2246 7049 2254 10755 2251 26281 3730 8074 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels 3764 6833 55970 3760 3761 2550 3759 3772 54331 59345 3762 3763 3765 3766 3768 10060 2793 2792 2791 3773 2790 3758 3770 2788 2787 2782 2786 2785 2784 3767 2783 10681 51764 94235 9568 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression 5753 2908 27043 2034 3091 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition 6222 6224 6218 6217 1983 6230 6231 6234 6235 6191 6193 1965 8894 6192 6194 1968 6227 6229 6228 1975 1977 3921 1981 1974 1973 8662 8663 8661 8666 8667 6232 8664 8665 27335 3646 51386 7458 8668 8669 10480 1964 2197 140032 6201 6203 6202 6210 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 96%5654741 Signaling by FGFR3 2591 5515 5516 5518 10817 5335 2549 10253 8569 7311 7314 867 4893 6654 2254 3265 5781 8074 673 5295 2249 2247 2246 5290 8823 6233 5594 7316 5595 10818 8817 26281 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA 55289 54677 8309 3295 10005 8310 1384 23600 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9656255 Defective OGG1 Substrate Binding 4968 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism 6382 2719 5549 126792 221914 9672 1462 9060 2239 4166 3074 4969 3073 63827 1634 26229 4958 2132 2131 633 2683 6487 1464 176 1463 3339 10675 4060 1836 22856 113189 2262 11285 2331 2817 9469 6383 10082 6385 375790 11081 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade 5155 4233 5156 6714 4893 5588 6654 3265 115727 3562 673 3559 3558 4140 25759 5594 5595 6300 6464 5979 10818 5906 53358 5900 7529 5604 3815 5605 5500 51125 5747 5536 3716 51114 88 1740 2906 4747 2902 2534 25780 1445 808 10125 3718 2064 2342 3561 2339 6708 6709 9978 10434 51332 6711 6710 8649 6712 9986 377630 81926 58489 51104 28956 80824 685 255324 4684 2069 3674 1839 57731 10048 3084 402 9965 1852 2254 152559 2252 1850 2251 11221 5774 27006 1844 8074 2249 1843 2248 1847 2247 2246 152831 8823 8660 2264 2255 1742 3667 1741 1739 8817 23179 26281 8682 8452 9462 221002 4763 7010 64926 284 84078 8831 5863 399473 22808 10156 161742 9693 200734 22821 54756 5923 2676 153090 8036 5924 2675 8437 84292 57139 5921 5922 5623 5159 64096 5786 4902 2323 2322 9048 5778 1849 1848 1846 5593 3845 3563 3560 1437 1439 1438 3568 3567 9861 6233 4296 7316 8315 5245 3717 10213 2244 5706 2266 815 5501 7414 5707 816 8844 5708 817 10256 5709 818 54518 8826 22866 5519 7450 5700 5701 3690 5702 5894 5037 5704 5705 2243 1956 7039 7094 5682 5908 369 5683 283455 5515 408 5684 5516 409 5518 5685 5686 5717 5718 5719 11047 5713 5714 5525 7979 5526 5690 5691 5527 5692 5528 5693 5529 5694 23463 7311 5695 7314 5687 5688 5689 2668 10817 9542 2674 10718 145957 2904 374 1950 598 3082 5295 5296 5290 5291 5147 2335 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%8868766 rRNA processing in the mitochondrion 51001 55178 79922 3028 130916 84881 285367 29960 60528 387338 54931 22868 26995 51335 81554 51106 9692 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%5357801 Programmed Cell Death 5062 4836 1613 1612 23604 219699 9500 90249 26060 1499 999 708 5588 5594 5595 7534 10971 7533 7529 22900 57099 55075 56616 6774 23643 10000 5747 7099 7532 207 208 1630 11140 5534 6093 4001 7531 840 2620 118 7431 4137 28988 10018 5339 356 2339 6709 10134 317 5366 839 324 2934 1677 1676 3148 572 842 7157 637 3836 8772 92421 3002 355 27243 3553 128866 834 10211 10015 837 838 7332 8743 5071 83737 79643 51074 841 51652 23368 8737 329 11035 54205 2319 3606 8795 7186 8473 3660 10273 8797 57162 79792 330 51765 331 4976 578 8428 1991 22985 29082 10059 7027 7159 6304 8626 6386 115209 91782 929 3552 25978 581 353376 1687 148022 3146 8717 197259 7161 7029 1869 8655 63967 3320 27113 79658 3837 5533 5580 90427 9861 6233 7316 10213 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 140735 5683 5684 2810 5685 5686 5717 5718 5719 11047 5713 5714 3009 7979 3008 5690 3007 5691 3006 5692 660 3005 5693 5694 7311 5695 7314 3024 5687 5688 5689 1832 1830 100506658 9414 1829 1828 7082 836 5317 1029 5599 596 598 3659 PKR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9833482 PKR-mediated signaling 1147 5519 3608 5515 5516 5518 103 201254 983 9246 5525 1965 8894 4869 1968 3551 8517 5608 7341 25820 5771 9636 7329 3304 57506 6772 3312 6774 51191 7706 3306 54920 3305 5610 8575 5611 199990 6895 55120 91442 7157 57697 378708 6622 4690 80233 8877 2175 2188 2187 2178 1660 3609 2176 2189 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 96%210993 Tie2 Signaling 7010 284 285 2888 4893 2886 51378 6654 3265 5781 5295 5296 5290 5291 6464 9046 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%352238 Breakdown of the nuclear lamina 839 4001 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 96%189085 Digestion of dietary carbohydrate 27159 1118 3938 278 279 11181 6476 8972 280 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) 3553 7321 5062 841 4791 7322 997 10454 7334 7335 4893 7189 26253 64170 3265 50856 257397 64581 170482 23118 10462 93978 338339 5567 5568 2033 5580 9020 3710 29108 1387 9861 8454 5336 6233 7316 10892 4772 4773 10213 2534 6885 5534 5706 23291 6850 5707 4775 5708 808 5709 1147 5530 84433 5532 5700 5701 5702 5894 5704 5705 10768 3708 4790 5682 3709 5683 5566 4792 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5970 5695 7314 6500 3551 5687 5688 8517 5689 8915 9039 143662 9040 118430 4582 4583 4584 4585 4586 200958 727897 56667 4067 10071 94025 140453 4588 4589 283463 5971 3385 5058 3384 9252 394263 5170 30835 2207 5063 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit 6230 6231 6234 9349 6235 6191 6193 1965 8894 6192 6194 1968 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 1974 6133 1973 6132 8662 6135 8663 6134 8661 6137 8666 6136 8667 6232 8664 6128 8665 6129 27335 3646 6142 51386 6141 7458 6144 8668 6143 8669 6146 10480 6147 1964 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 6222 6224 6181 6218 6217 1983 9669 7311 1975 1977 1981 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi 6484 6400 2683 6487 4851 5986 4242 5045 10402 3955 487 10959 5870 488 4853 489 4854 4855 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 3030 34 51102 1892 3033 3032 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors 5624 2677 2159 2158 2147 2155 8858 632 5627 2621 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665230 Drug resistance in ERBB2 KD mutants 3320 55914 2064 11140 THE NLRP3 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844456 The NLRP3 inflammasome 5970 10910 9051 834 4790 10628 4210 351 29108 114548 3326 3162 7295 24145 4791 5027 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 5879 5361 5362 6237 9855 7094 23396 27289 55558 91584 10371 8829 2242 2534 DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) 340024 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME%R-HSA-9763198.2 Impaired BRCA2 binding to SEM1 (DSS1) 7979 675 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 96%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 9125 25904 9775 55571 27161 85456 246175 23405 57472 9337 10605 1975 26986 23019 1977 4850 678 29883 390748 1981 1974 54766 4848 1973 4849 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB 808 817 818 814 3838 84254 10645 815 816 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 96%9010553 Regulation of expression of SLITs and ROBOs 1287 6230 6231 6234 9349 6235 6191 6193 6192 6194 9353 51121 6091 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 23053 6201 6167 23708 6203 3670 6169 6202 23032 116832 6160 8453 6161 2107 4440 26986 6175 1605 9045 2935 6210 6176 9355 6171 8022 6170 6173 6092 51065 9861 26019 6205 6204 6233 6207 7316 6206 56956 6209 10213 6208 6188 5706 6187 6223 5707 6189 5708 6222 22916 5709 6224 6181 6218 5700 89884 6217 4686 5701 65110 5702 5704 6585 5705 3199 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 6921 5695 9978 7314 6923 5687 5688 8861 5689 22794 1981 9939 65109 9775 10921 55110 4116 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 96%9014843 Interleukin-33 signaling 9173 90865 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 96%380095 Tachykinin receptors bind tachykinins 6870 6865 6863 6866 6869 ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964540 Alanine metabolism 2875 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8931987 RUNX1 regulates estrogen receptor mediated transcription 57678 2099 8312 861 200845 865 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 96%400508 Incretin synthesis, secretion, and inactivation 2864 1499 3670 2626 5122 346562 28972 60559 5080 2782 2922 1045 338557 9789 139760 2784 1803 2641 2695 90701 23478 51764 6934 3952 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation 6222 6224 6181 6218 6217 6230 6231 6234 9349 6235 6191 6193 7311 6192 6194 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 1938 6168 6201 6167 6203 6169 1915 6202 116832 6160 6161 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9679514 SARS-CoV-1 Genome Replication and Transcription 1655 85437 7428 5925 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 96%77042 Formation of editosomes by ADAR proteins 103 104 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 96%173599 Formation of the active cofactor, UDP-glucuronate 23169 11046 7360 80146 7358 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 96%9022702 MECP2 regulates transcription of neuronal ligands 3065 1392 25942 6750 28514 627 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 23462 79885 3280 8850 9794 83933 7311 4851 9978 7314 6500 3066 5663 10046 5664 388585 55851 83464 23385 51107 26508 9612 9759 22938 3065 84441 1024 9734 2033 6907 4609 2648 9148 79718 28514 182 54492 57534 102 54567 6868 51564 3714 142678 8841 10013 9611 23493 10014 1387 3516 8454 6233 7316 55869 892 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants 5500 7529 5894 22808 8036 369 5501 673 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) 9630 2151 55970 2149 2147 408 409 9002 54331 59345 2768 2767 10672 2769 2793 2792 2791 2790 2776 2788 2787 2782 2786 2785 2784 5594 5595 2783 10681 51764 94235 SARS-COV-2 INFECTION%REACTOME%R-HSA-9694516.9 SARS-CoV-2 Infection 3105 567 100128731 8678 23479 81631 7405 6185 6184 10454 7334 7335 2932 746 7189 1603 257397 5781 23118 7534 10971 7533 5777 64135 3442 7529 3441 3440 23586 80143 84282 84061 57506 91662 22863 3452 27072 3451 6772 3449 3448 3446 3445 3444 11282 3443 7706 7841 29801 6733 6732 25921 253832 51201 23339 7991 55741 11320 51125 201595 10000 4247 51304 3703 4249 10610 6483 6482 6484 23765 3716 6487 4245 857 4124 1650 6480 25834 23193 256435 7532 11311 79844 2530 27090 11253 207 5589 51114 208 64601 9868 7415 1387 114548 8829 6383 10082 6385 65082 1655 6382 7297 7531 7097 7096 6773 221914 9672 112744 3326 2239 3454 3654 84818 3107 3106 5045 3339 3134 3133 9908 2697 10146 2262 3135 2817 7113 6441 59272 26762 2719 7555 57617 85437 23367 51128 55823 9871 9632 10427 26276 5289 10802 9883 3605 10484 129401 26007 9688 30849 23225 4927 23165 375790 55706 92421 23636 9972 9631 27243 7175 11097 128866 23511 3276 8086 8021 53371 8480 10762 79643 51652 6230 6231 6234 6235 8767 6191 6193 6192 6194 29082 6227 6229 91782 6228 7187 25978 9641 64127 10392 3921 5925 6232 3656 9636 821 3320 2197 348995 2589 54956 140032 143 3838 2931 63982 57122 56965 83666 79668 203859 84875 54625 6201 55746 6203 89122 6202 23279 57101 79023 51284 51311 6396 4153 338440 6210 51065 6205 6204 6233 6207 7316 5648 6206 6209 6208 6188 6885 6187 6223 6189 55107 6222 5903 6224 1147 6218 6217 340061 3665 2810 55129 50636 7284 79902 196527 57719 7311 7314 121601 3551 8517 7341 1514 7082 7329 3456 7428 29110 3661 1452 10207 92359 64398 50628 6632 6628 79760 54960 5170 6634 6633 6636 6635 58505 6637 25929 79833 6607 8487 11218 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9762293 Regulation of CDH11 gene transcription 26508 2294 56978 6667 9839 27319 3224 3609 6615 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling 5782 8065 2064 1956 3084 3320 9542 10718 145957 9101 10000 1950 10273 7311 7314 207 208 55914 10193 4145 6233 26469 7316 685 11140 2069 1839 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 96%3229121 Glycogen storage diseases 7314 7957 92579 8908 378884 2548 6233 2998 2538 2997 7316 2632 5507 2992 2542 7311 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 96%166187 Mitochondrial Uncoupling 7350 291 7352 7351 9016 9481 148811 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling 5881 192670 27161 64750 26523 1499 5879 1213 23112 1211 160 161 57690 192669 163 5880 4919 4920 1175 1173 81029 4343 1855 1857 1856 5145 6259 27327 5578 5592 5593 5158 83439 5148 3710 57154 51701 5330 5331 2780 23236 2775 51176 57216 9861 6233 7316 5579 4772 10213 6885 5534 5706 815 5707 5708 808 5709 5216 5530 5532 5700 5701 5702 5704 5705 3708 5682 3709 5683 5684 409 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 2793 2792 5689 2791 2790 7481 2788 2787 2786 2785 2784 2783 51764 94235 54361 55970 1212 54331 59345 7855 7976 8321 8322 7474 8325 387 23002 8323 8324 50855 5582 2782 7471 23513 2535 10681 6932 144165 6934 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610785 GLI3 is processed to GLI3R by the proteasome 5708 5709 5700 5701 5567 5702 5704 5568 5705 5682 5683 5566 5684 5685 5686 5717 5718 5719 8945 11047 5713 2737 5714 7979 5690 5691 5692 5693 5694 7311 5695 9978 7314 6500 5687 1452 5688 2932 5689 9861 8454 6233 7316 10213 5706 51684 5707 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5619113.4 Defective SLC3A1 causes cystinuria (CSNU) 11136 6519 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654700 FRS-mediated FGFR2 signaling 4893 6654 2254 3265 2252 5781 2251 27006 8074 2249 2248 2247 10817 2246 8823 2255 10818 8817 26281 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 96%8955332 Carboxyterminal post-translational modifications of tubulin 23287 254173 25941 374969 60509 79739 54839 158135 284076 10381 22846 10383 9654 10382 164395 123624 112714 26140 23093 83887 23170 79841 7846 91978 84276 84790 150465 79805 340351 84871 84617 260334 347688 347733 7278 81027 113457 7280 10376 25809 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660516 Synthesis of PIPs at the early endosome membrane 55300 8898 55697 4534 5289 55361 54893 9110 30849 22876 9896 5286 200576 3631 8821 54545 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME%R-HSA-5083627.3 Defective LARGE causes MDDGA6 and MDDGB6 9215 11041 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 96%9913351 Formation of the dystrophin-glycoprotein complex (DGC) 3910 3911 3912 137868 1756 6645 1838 1837 6641 6443 6640 7402 6442 6445 6444 3339 8082 54221 8910 1605 1821 3913 3914 3915 3918 284217 10319 3908 3909 375790 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) 9899 9900 6616 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 96%69278 Cell Cycle, Mitotic 8331 8337 8334 51400 8335 51451 90381 79596 728642 984 63943 79866 51512 8341 8342 8347 55320 8348 8345 55355 8340 23649 8338 5422 85236 8349 5557 5558 2932 91768 7465 286826 114799 8370 132660 91750 1163 5753 55957 157570 3013 255626 3021 3018 3017 3014 474382 10000 8970 128312 55766 8968 7532 207 208 653604 5577 5928 3978 113457 140609 10783 91754 7280 10376 80086 51807 10381 10383 10382 112714 7846 84790 84617 22822 347733 7277 7157 3161 7278 81027 79861 9883 129401 9688 23225 4927 23165 55706 23636 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 8815 84515 5000 5001 23594 23595 4998 6790 4999 10133 2305 7153 4149 10142 3320 3837 7840 5578 11064 22994 22995 8317 7283 203068 10776 55722 1453 79648 5862 9738 255919 84930 11190 2029 55844 5901 54892 23310 25836 95681 23383 27436 8548 23399 29781 1069 26003 9861 8454 6233 7316 54801 10540 5579 10213 4218 5706 23291 5707 5708 11116 5709 5700 5701 5702 27183 5704 5705 54930 5682 5683 5684 79959 5685 5686 5717 93323 5718 5719 22981 8945 11047 5713 5714 7979 80254 5690 55755 5691 10806 5692 5693 5694 10121 7311 5695 7314 6500 9662 5687 5688 5689 7341 10733 80321 55125 9814 3930 115106 79441 7329 9702 3842 5108 5981 5982 55142 5983 22897 56655 5116 80184 5111 23354 8481 55732 6117 5984 5985 121441 5424 6119 5425 55559 6118 1454 5426 8636 5427 11258 84131 4957 10714 57804 9232 5933 5934 4659 1763 4605 54107 51529 7321 8881 64682 25906 1104 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 7443 996 9798 22933 51434 51433 221496 5347 200014 2010 9700 260334 6683 347688 22974 23141 85378 64151 10426 10592 29922 27229 9918 23397 440145 80097 10051 4926 114791 27175 23592 653784 10844 9663 5594 3065 64900 23175 5500 2033 5520 7514 1859 7298 28227 7083 1719 26271 4001 7531 2801 993 994 3326 995 4172 4173 4174 4175 4176 64785 8318 9837 84296 4171 9978 51659 6241 25 92421 27243 128866 79643 51652 9088 29082 7027 1021 91782 1019 595 1017 25978 894 55835 896 29935 1871 10926 81620 898 1870 51343 2237 6502 51053 55388 9134 1028 1027 1026 7029 1869 5925 54908 6232 8655 25909 8379 9183 23047 1063 1062 9184 1060 991 151648 1876 55166 1058 1875 79019 1874 151246 9735 23332 79003 55055 81565 22919 113130 348995 348235 9126 5048 23421 57122 220134 57082 57405 147841 51143 6249 55746 387893 4085 9133 64105 84962 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 1781 23122 23244 1780 79172 1778 81930 10735 55920 84643 3796 9793 91687 57551 79682 3717 5905 1783 5501 83540 80152 5903 2491 10112 5519 332 55143 9493 23063 699 11243 10274 140735 3619 5515 5566 11004 5516 5861 5518 9212 25936 8243 11130 64946 79980 10726 79902 5885 5525 5526 64689 55839 5527 5528 5529 80028 890 8615 81876 8290 6418 4331 1022 1032 1031 1030 1029 8900 23194 902 1460 990 1459 1457 4609 4067 94239 4751 8556 54145 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope 6701 6704 643418 6703 3713 6706 6705 643394 63036 353134 43847 23254 353133 43849 353135 7051 353137 353139 126638 199834 353141 823 2312 149018 826 353140 353143 353142 1825 1824 1823 6698 353145 64065 353144 1041 7062 448835 5045 2125 5046 23581 1475 142910 6768 11005 5318 11202 147409 9333 1832 5493 1830 25818 5652 254910 1829 6699 1828 340654 5317 26085 8502 404203 3728 5266 4014 26239 6707 84648 353132 353131 6700 643414 11187 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764265 Regulation of CDH1 Expression and Function 8331 8337 8334 8335 100128731 192670 27161 8341 8342 8347 8348 8345 3170 26523 8340 9314 8338 2060 79872 1500 85236 1499 8349 54971 999 6185 23112 6184 6714 57690 3066 192669 746 1603 6591 8370 5594 5595 5925 2146 6597 4343 3013 3065 255626 117581 821 3021 8289 3018 3017 7841 3014 474382 90701 3703 8970 128312 27327 387893 55766 1650 8726 8968 1520 23193 1508 28972 5589 23411 653604 9861 6233 23512 7316 1495 5928 23028 23478 10213 5706 7020 7414 6615 5707 7764 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 27085 5719 6929 11047 5713 5714 94234 7979 5690 5691 5692 5693 5694 7311 7291 283106 5695 7314 5045 5046 5687 4193 5688 288 5689 6938 1514 7490 10399 54737 348262 5315 7750 10009 60436 7088 9159 11171 55810 687 93986 1460 1459 9789 1785 1457 6667 9839 4609 5931 29954 10585 94239 6935 4613 23396 60559 1488 1487 3728 54145 58505 9743 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation 8331 5087 8337 8334 8335 3199 8341 5080 8342 8347 8348 8345 8340 3725 8338 57472 85236 8349 6256 8370 5440 5441 2146 7528 7403 9125 3013 1959 5434 5914 5435 5436 255626 5437 5438 5439 3214 5430 5431 5432 5433 3021 3018 2033 3017 3014 5915 474382 5931 5916 7703 8970 128312 4211 22976 3200 9063 94239 55766 84962 9070 9935 8726 3211 8968 79447 3201 10664 3221 63925 3213 3212 5316 8841 9611 3233 3232 653604 3198 3231 1387 84661 23054 11091 8085 23512 54145 5928 5929 8202 58508 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9609507 Protein localization 7321 8604 10165 5621 2010 5264 27235 5195 5189 1384 5192 23600 3155 5193 283927 5825 5194 1610 5828 54677 390916 7322 8528 26063 4843 1962 122970 51 8540 215 5190 11001 5191 3295 54363 30 23480 8504 10005 10901 225 51179 10952 8239 8310 9381 219743 373156 2053 6811 570 3416 55825 51268 8309 6342 498 1891 3313 55670 10965 91452 189 196743 4358 10651 54469 516 26061 3329 4580 5824 25813 3417 5009 506 54927 3162 9868 6233 7316 351 80273 9512 23203 7416 7311 7314 27230 83752 2671 100272147 9218 10531 400916 6901 8266 5827 56942 92609 197257 29928 8799 51142 51025 51024 819 134266 2395 8443 79145 54543 3421 9804 29090 10245 6844 9409 26519 6804 7485 26515 26517 847 7917 617 150274 51287 11264 439 50 1537 10452 90639 51608 10063 26521 10478 10469 26520 100188893 100287932 54332 1678 7323 401505 84269 56993 1431 6449 131474 131118 84896 388753 10440 4714 291 293 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane 11116 84902 7531 54930 5566 79959 5518 4867 93323 9657 91147 983 22981 5347 27077 80254 55755 10806 85302 10121 9662 347240 55835 22832 57787 57545 10733 80321 55125 9814 26005 115106 8655 79441 79600 26123 9702 5108 55142 10383 22897 10382 79598 10142 5116 23332 80184 3320 22919 7846 132320 5048 8766 23354 146057 8481 7840 11064 121441 23322 22994 79867 22995 7283 7277 55559 203068 1454 8636 55722 4751 11258 1453 7532 54820 84131 9738 80776 54903 11190 4957 1781 261734 95681 1778 117177 1069 5577 51134 9793 54801 10540 51259 54806 4218 4735 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME%R-HSA-5655799.4 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) 30061 9843 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 113612 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity 60436 22938 23439 3065 4087 4088 4089 142 7321 64750 51592 4092 7311 7323 7314 7050 23327 8239 9611 25937 9612 6498 6233 5594 7316 5595 6497 5494 54778 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition 5347 26271 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 96%381038 XBP1(S) activates chaperone genes 37 51726 7094 100137049 118 10130 58477 22872 6745 10897 4000 10525 2931 5611 9797 55738 4189 5526 2673 10106 1663 7466 3068 55062 84447 10954 1639 9695 30827 116138 7709 56005 27230 55033 9114 1200 2134 10113 6734 2137 64061 2135 11015 9820 9570 6464 6818 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME%R-HSA-5657655.3 MGMT-mediated DNA damage reversal 4255 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%166662 Lectin pathway of complement activation 78989 8547 10584 5648 2219 4153 2220 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 5624 2159 2158 2147 2155 8858 632 5627 2621 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation 3716 3569 5605 5594 7297 3570 3717 5781 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling 4804 4803 6610 DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 96%3359467 Defective MTRR causes HMAE 4548 4552 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 96%425561 Sodium Calcium exchangers 808 6547 9187 6543 80024 6717 57419 123041 25769 6546 283652 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism 64087 152926 3028 26275 549 10249 56922 3712 594 10295 1629 1738 593 9673 36 586 587 27034 11112 4329 1892 38 1384 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-HSA-418592.5 ADP signalling through P2Y purinoceptor 1 9630 2769 55970 2793 2792 2791 2790 2776 2788 2787 2782 1432 2786 54331 2785 5321 59345 2784 5028 2783 10681 2767 51764 94235 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022854 Keratan sulfate biosynthesis 93010 79369 10402 10678 5549 8534 8703 8704 9435 8702 4166 4969 4958 6483 6482 6484 2683 6487 176 4060 10331 9334 11041 9331 2331 11046 9469 23563 11081 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 96%380612 Metabolism of serotonin 217 4128 SELECTIVE AUTOPHAGY%REACTOME%R-HSA-9663891.5 Selective autophagy 65018 140735 7332 5071 81631 55669 9927 53632 7417 7416 7311 7419 7314 7322 7334 7335 8408 2034 10133 8100 8655 8878 54543 9804 5563 472 3312 5564 5116 5565 3320 10226 1460 10452 5571 1459 29110 1457 100188893 51143 7323 51001 401505 56993 51422 1781 10013 1780 9868 7415 1778 3297 9140 9474 6233 84749 1080 200894 7316 84557 139341 123 4077 1068 5830 79065 1783 11315 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 96%597592 Post-translational protein modification 8331 8337 1294 8334 8335 100128731 8341 8342 8347 8348 8345 91445 6048 135228 8340 10987 813 338328 255738 8338 4791 10956 85236 8349 29106 5034 6185 6184 5874 116519 746 5768 1603 2034 22915 213 197 336 8370 79139 51009 6400 3013 154 255626 84061 6694 3018 3017 334 7991 114785 3054 201595 55252 55777 3703 3607 8970 7345 128312 7347 221937 123228 8314 2683 171023 3098 51035 1650 10331 7518 30815 11041 7415 11091 23512 5929 6383 124872 10402 2804 6881 9100 440138 10130 79694 64426 6921 7466 6923 1639 9695 9334 9331 113457 90268 26503 7280 26272 9986 26234 377630 11015 6468 10376 26190 26270 79369 2719 10381 10383 10382 55294 112714 8703 8704 7846 8702 60 84790 84617 10238 10517 347733 84261 7157 7278 26224 81027 54461 9883 129401 9688 23225 4927 23165 55706 23636 9972 9631 93010 7175 11097 23511 10678 8086 8021 2525 53371 8480 10762 92305 6596 23168 9781 79577 51322 126119 5195 92552 80349 7040 9929 5192 5193 5194 5828 6194 123169 51255 9646 27005 257218 55829 9810 220441 56957 6228 54623 7375 7187 9641 1540 7128 2621 4061 6132 5627 811 9112 25809 23287 254173 25941 374969 60509 79739 10210 142 54839 821 158135 4248 284076 22846 9654 164395 123624 6157 26140 23093 83887 5873 23170 79841 91978 84276 2589 150465 79805 340351 84871 5610 5611 5862 8693 2590 55568 442117 374907 84002 11227 11226 374378 51809 6996 64409 6187 84752 140687 9245 114805 2650 168391 192134 63917 199857 117248 51146 79868 146712 51301 26290 50614 57452 79623 10164 8875 8876 57719 7417 7416 7419 6670 3090 668 652 9804 11338 10890 1000 5872 51552 387 3913 1080 84749 3915 2335 146664 115827 11315 64284 161725 4978 22854 503542 3912 100287327 55593 27076 3105 148789 2350 10617 7879 84920 8313 2109 93624 10652 57799 10868 57559 3998 10869 5865 143471 376267 389362 22818 5698 1043 5699 26286 80328 56984 22820 51371 83844 80227 84932 5710 1048 10197 79589 122706 6975 5711 10600 8624 146183 5715 23326 5716 79931 84262 54872 5696 8934 9491 10026 23198 161357 5720 3895 1087 5721 100287178 7322 29089 997 419 10454 4122 7334 23556 420 349667 7189 8733 432 433 55768 8724 284098 6811 100287144 11316 3371 683 23770 6314 91833 80740 349633 100287364 9609 326624 2200 94005 79091 53942 152330 11070 5624 5277 5279 64135 3065 254013 79087 249 85365 5283 130576 29929 23586 10195 251 1435 79796 84282 5281 57506 23275 9526 401258 56052 5067 79053 347517 1798 91869 93183 8581 7007 4286 360226 11019 221143 7706 11014 5372 2813 5373 4351 100287513 27247 29926 2822 29925 5878 55288 5868 401447 5869 80235 9487 9488 9486 1081 146760 7070 50863 51715 9276 84628 23032 53916 53917 1315 8453 1314 646627 2107 113829 387787 80055 2653 84892 1605 100287238 100287478 120071 728386 57403 57646 100287205 257194 100287441 2218 1368 2215 100288520 401409 144245 58530 22944 100287404 55031 10966 57695 284348 3183 154064 26958 25862 56254 79812 128869 140838 390243 9318 54764 29906 207063 55611 51014 6675 81849 23423 7512 51046 5973 266727 51005 51272 22845 5329 4253 55808 2873 55647 6489 64841 353091 51138 5476 25837 10020 137797 256281 219333 79644 78990 10825 55650 55577 51299 7425 2673 79609 10537 8813 84197 55208 9945 84196 197258 28952 9960 8818 23627 23142 7264 26094 64377 338596 10318 54939 8790 9655 170384 55343 5045 23038 4045 140825 29880 55432 10559 10329 23369 7046 84620 729920 54951 7048 116372 23363 2762 54165 8869 4062 5238 115273 9306 149951 23172 116150 55907 1161 51651 80344 8128 9761 8434 55827 57171 282969 372 23113 84259 54187 84101 80896 381 56929 79016 54344 142684 51122 79947 9527 54876 7903 7369 4758 9545 50717 129807 83987 392188 4759 150684 399818 8816 171169 90864 54965 170622 196483 10116 64772 10670 64344 54732 29099 51227 79269 51226 51397 8000 55884 23358 55527 54742 23412 8878 84132 145173 56995 123904 28991 57188 80124 2591 80067 84720 143662 123879 83871 79695 8883 645836 10417 57111 122416 118430 10942 10418 147719 170689 375 29761 171019 83639 54437 3312 79147 645402 324 9510 129080 9037 51601 4582 51604 5199 84992 4583 84750 7058 2517 4584 151194 4585 1522 8078 4586 728419 200958 8073 51128 157869 114803 29954 4706 727897 27314 56667 29071 9507 9871 80070 9632 10585 140766 10427 27430 9508 9509 10071 94025 4597 339366 221981 79875 81794 140453 55901 4588 4589 81792 55624 283463 8074 8720 9719 10802 56999 56913 11093 10484 394263 11173 11096 11095 11174 9215 80731 170690 54507 170692 92949 170691 1737 7332 5071 154881 8737 6478 329 283807 51088 7186 9616 8473 7317 462 7319 330 3093 7336 1471 150726 118424 55336 7327 7326 4240 7328 54926 65264 93611 127247 401036 79791 51665 51666 63891 142686 2147 142685 55236 51676 142689 80204 8451 57542 7320 8450 56852 1642 57599 51514 23014 3827 25793 11275 89122 64410 222235 54850 140456 140458 140459 90135 444 146330 140460 140461 140462 54620 115290 1743 7704 55958 8139 390594 55284 84961 139285 2155 8924 122769 79697 89978 1819 83475 285362 64122 55175 8535 23210 8460 27252 1984 51130 79642 2677 2159 55854 2158 9903 377 3490 25870 8858 8459 51611 4733 92369 65094 340075 126433 91433 648 26259 23463 4194 79672 410 412 6015 201456 80028 79831 84864 144699 890 414 899 415 4193 84861 92912 92715 1912 416 10477 1911 51389 26268 91851 285381 120526 90293 22901 84727 153642 80012 92591 100137047 26263 84733 347527 26267 53339 55239 10489 56648 1725 285231 89890 1802 11167 1801 9820 26235 26118 6045 79176 26232 84085 4008 9817 51725 9039 1029 26249 3569 8065 140739 9040 79754 8900 84541 57332 80176 23194 7428 136371 10324 374 55738 1938 1915 102 10970 1487 440689 721 718 90865 8678 248 1789 1788 1786 64326 3416 1154 5423 8835 11282 7841 55741 11320 4247 4249 10610 6483 6482 6484 6487 4245 4124 6480 25834 84364 23193 256435 2530 27090 11253 5589 9868 114548 3630 8975 81847 23252 5987 57134 4121 8658 80351 10905 23682 11031 116442 23011 10981 22931 54734 55666 201475 1122 3190 57104 10474 7353 5875 4303 5876 2923 3486 3484 4905 10945 632 55860 51164 2890 10671 7874 93661 23314 84516 6790 25942 9189 197370 493861 9994 115426 8767 57591 7690 79677 56160 54780 10521 6672 205564 6304 10055 10054 51602 3066 286053 11274 25950 200845 64127 23137 4152 59343 29843 6294 7153 7155 10392 7150 79155 9612 9097 8312 9656 10072 1453 79594 9738 51564 26043 7022 1069 7021 9861 8454 6233 7316 10540 10213 6885 4218 23468 5706 23291 5707 5708 5709 5700 5701 10155 5702 5704 5705 7039 5682 378 5683 4792 5684 5685 5686 5717 114907 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 7057 5694 10121 7311 5970 5695 7314 6500 5687 5688 8517 83746 5689 8915 7341 7068 5241 7376 6256 7421 5465 8554 2099 7181 8729 6095 367 4929 2908 51588 6612 9021 9759 5468 2625 7329 6613 4306 2516 5914 10401 7486 672 28996 8766 5111 79823 641 6117 2648 79728 11258 580 8774 8775 1107 7321 22796 9382 11065 51560 7324 10618 51209 27338 25839 5870 983 83548 63908 9146 57511 260334 1121 10466 347688 8027 11021 9367 9363 339122 4869 51762 9099 5728 10254 84342 91949 83452 338382 9230 5867 2033 335 7703 8648 338 10891 10499 84447 4780 4221 8204 221656 1387 808 1655 351 2801 993 8850 6708 6709 9978 286 287 288 51332 6711 6710 6712 7528 6696 57731 5371 4287 348 5864 7323 5179 8533 1604 64708 8452 8607 4086 125476 4087 84078 10980 4088 93973 4089 29844 54891 79913 50813 54617 10920 283899 64750 83444 5886 1462 5887 4798 4092 10445 7508 3972 2720 411 51246 54757 8404 8542 3491 3488 3487 64856 10117 1114 258 7857 10232 8239 5954 86 56955 1758 830 6502 4241 832 3270 1616 265 401138 51156 1026 147111 51280 829 56975 3956 4924 3053 8655 8614 2519 375056 7076 10272 174 80341 54972 4148 3698 991 29086 84141 9210 51720 11098 54587 63967 4052 84142 165918 7158 5893 9577 1643 9958 348995 79184 9736 9126 51377 57122 9101 10196 317772 51143 92815 55746 85235 8969 221613 8295 23279 79023 7184 6396 1781 59348 1780 1778 10735 3622 5905 1783 2266 5591 5903 332 55143 2243 10274 140735 3619 79090 408 5265 409 6399 5861 23243 9212 22870 2153 8243 22872 2348 10175 5537 79902 10972 5885 9554 80267 9117 11196 10299 64689 10206 56886 126003 267 55291 7844 23256 1075 55757 11236 58485 254263 25956 55014 81562 51693 2157 122553 8615 966 10342 27095 149111 9919 81876 83696 10959 10113 90411 4738 10282 26984 9570 51399 89866 79748 7109 128637 10960 1356 7018 55832 2230 4609 25879 5931 3091 1629 58505 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination 4508 4509 64432 65003 64951 65005 65008 28977 90480 51081 6150 55168 64949 28973 65080 51642 5018 54998 10573 11222 128308 51649 9553 64960 92259 63875 64963 64965 64968 55173 55052 64969 51373 4512 26284 4513 51650 4514 60488 51253 51258 219927 29074 56945 64975 28998 64976 79590 64979 64978 23107 28957 64928 7818 57129 51263 29088 51021 54534 51023 51264 51069 84545 78988 4519 122704 65993 64981 10240 64983 3396 26589 63931 6182 54460 6183 118487 51073 116540 740 54516 124995 9617 54148 84340 116541 4540 55037 29093 4541 9801 4535 4536 51116 10884 4537 54948 4538 51318 4539 92399 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses 64135 8065 3442 3441 3440 23586 3456 7297 57506 3452 3451 6773 3449 3448 3446 3445 3444 2033 3443 7706 3454 3661 5610 7311 3716 6921 9978 7314 6923 1387 6233 7316 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1483206 Glycerophospholipid biosynthesis 114879 114882 85465 5920 5337 79143 56910 248 9600 1040 57605 83394 10423 9663 8694 8398 84649 2820 129642 255043 8605 11145 10162 123745 79887 255189 11343 50640 50487 151056 54947 64900 150763 23175 23646 5321 55750 10390 9468 126969 1120 204962 162466 10809 158835 80736 56994 1119 57153 5130 23446 84879 171586 58488 10400 122618 9791 81490 8399 374986 5320 137964 5322 26279 283748 201164 6901 81579 84803 55326 80821 56894 56895 51205 5338 10554 253558 5319 10555 8443 22925 200879 57104 64600 23259 23171 100137049 84895 254531 79888 3032 149998 3030 2819 30814 590 1460 1459 1103 1457 43 57678 8895 51365 56261 63874 57110 27132 283871 64850 9489 9362 55500 114971 55224 5833 154141 9926 23760 23761 54675 347516 23659 114884 80339 117245 8904 54979 8760 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential 3768 8645 56660 83795 60598 3761 56659 3759 54207 9424 50801 3770 3775 338567 10089 89822 3776 3777 51305 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks 10111 4361 3838 4683 472 10524 INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic 8774 8775 9321 9267 22796 9342 9382 9265 57589 9266 375 27128 250 143187 347517 10652 9950 27333 57134 25839 4121 51272 10905 10228 83548 63908 27314 57511 10466 9827 8675 4124 4905 84342 4122 11311 83452 91949 1523 6811 9527 9570 54734 9609 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 96%73943 Reversal of alkylation damage by DNA dioxygenases 54890 221120 51008 84164 10973 121642 79068 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling 9542 5290 10718 145957 685 3084 2069 5295 1839 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 96%9861559 PDH complex synthesizes acetyl-CoA from PYR 1737 8050 1738 5160 5161 5162 SURFACTANT METABOLISM%REACTOME%R-HSA-5683826.5 Surfactant metabolism 1512 10568 6569 6440 2627 51816 653509 51201 5222 1755 221395 29080 5029 643834 9476 29995 21 643847 6439 135 136 7270 729238 150 152 1439 1438 10970 6441 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) 3425 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects 1029 1021 1019 MATURATION OF REPLICASE PROTEINS%REACTOME%R-HSA-9694301.5 Maturation of replicase proteins 23479 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9603798 Class I peroxisomal membrane protein import 5194 5825 5828 51024 5824 84896 215 8504 225 9409 11264 55670 91452 5827 10478 5195 54332 8799 5193 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME%R-HSA-9726842.2 Gain-of-function MRAS complexes activate RAF signaling 5500 7529 5894 22808 8036 369 5501 673 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022923 DS-GAG biosynthesis 633 1464 1462 1463 10675 63827 92126 1634 29940 10090 113189 51363 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma 259 8542 213 3263 3043 3240 3250 3040 335 9332 3512 4035 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 96%109606 Intrinsic Pathway for Apoptosis 3002 7531 840 140735 4836 10018 2810 51074 841 23368 54205 79792 331 317 578 708 7027 8626 7159 581 1687 7161 836 5594 7029 5595 7534 1869 10971 7533 8655 5366 1029 7529 22900 5599 57099 55075 56616 6774 27113 5533 90427 596 10000 598 572 842 7157 7532 207 208 637 5534 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation 6230 6231 6234 9349 6235 6191 8893 6193 1965 8894 6192 8891 6194 8892 1968 8890 51121 1967 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 1974 6133 1973 6132 8662 6135 8663 6134 8661 6137 8666 6136 8667 6232 8664 6128 8665 6129 27335 3646 6142 51386 6141 7458 6144 8668 6143 8669 6146 10480 6147 1964 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 26986 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 6222 6224 6181 6218 6217 1983 9669 7311 1975 1978 1977 1981 DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9920951 Dengue virus modulates apoptosis 55615 253260 5289 22863 54463 79109 4792 8678 4793 1616 8737 64223 30849 57551 57521 2475 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811434 COPI-dependent Golgi-to-ER retrograde traffic 10112 8774 8775 26958 9493 3831 3832 3835 378 51014 56992 24137 23423 89953 11004 29127 5861 22818 26286 22820 377 9371 10972 9554 63908 285643 9585 55083 23046 55605 113220 3833 3834 90990 55850 23095 10749 372 81876 60561 55614 10959 381 146909 11316 6836 55582 23303 11015 3797 124602 53407 8729 64147 221458 662 51594 54732 547 51226 3798 3799 9183 1062 375 11127 11014 55738 9276 84364 1315 4905 1314 10945 22920 81930 84643 3796 64837 26153 147700 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins 57731 6336 11280 3897 3785 3786 6708 6709 55800 6324 6323 286 287 288 51332 6711 6710 4897 6712 6331 6330 6332 6335 6334 6326 6328 6327 6329 23114 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 2697 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380320 Recruitment of NuMA to mitotic centrosomes 11116 7531 54930 5566 79959 5518 93323 983 22981 5347 80254 55755 10806 10121 85378 10426 9662 29922 27229 440145 55835 80097 4926 114791 10733 27175 80321 653784 10844 55125 9814 115106 8655 79441 9702 5108 55142 10383 22897 10382 10142 5116 23332 80184 3320 22919 7846 5048 23354 8481 7840 11064 121441 22994 22995 7283 7277 55559 203068 1454 8636 55722 4751 11258 1453 7532 54820 84131 9738 11190 4957 1781 95681 1778 1069 5577 9793 54801 10540 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels 83795 89822 3776 3777 56659 54207 51305 9424 50801 3775 10089 338567 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 96%5693538 Homology Directed Repair 51750 54107 5888 80010 5889 10038 2067 8341 8342 8347 8348 8345 8340 85236 8349 7336 7334 1017 2237 8370 3980 142 255626 7468 29086 7515 9025 51720 54962 63967 151987 84142 165918 7158 3018 5893 3017 5531 3014 9577 79184 8914 6047 8970 128312 9656 10721 6233 7316 8924 3978 7979 7311 7314 890 8290 51588 7329 6613 348654 7486 5981 51548 5982 5983 3364 8900 472 56655 672 675 84126 144715 83990 5810 7516 5932 7517 9156 5111 11073 80198 641 55732 79008 6117 5984 5985 5424 6119 5425 79728 6118 5426 5427 5429 5883 5884 116028 10635 10714 146956 1111 197342 83695 84464 10111 51426 57804 25 4361 7156 54145 5890 5892 4683 580 23514 63979 10524 1763 2072 545 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism 5095 5096 4594 84693 166785 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation 3082 4233 MATURATION OF HRSV A PROTEINS%REACTOME DATABASE ID RELEASE 96%9828806 Maturation of hRSV A proteins 5045 5499 28972 60559 5500 3837 1460 9789 1459 1457 90701 23478 5501 7514 PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 891 983 991 5347 26271 51343 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery 2963 2962 5434 5435 5436 5437 6827 5438 6749 5439 5430 5431 5432 9150 5433 6917 1025 51497 11198 8812 25920 51224 6921 6924 7936 6923 7469 904 905 5440 5441 6829 8178 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production 8439 7132 10399 6610 7124 55512 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8963693 Aspartate and asparagine metabolism 443 2346 339983 10003 374569 8604 10165 2806 440 2805 339896 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription 60436 3065 4087 4088 4089 3726 4904 1875 1874 1024 1025 2033 4092 1278 6667 8812 4609 7311 5054 7314 5045 7050 7027 904 905 4221 25937 6233 5594 7029 7316 5595 5933 892 54778 1030 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation 3716 3569 983 5604 7297 5595 3570 3717 5781 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 96%442982 Ras activation upon Ca2+ influx through NMDA receptor 808 817 818 4893 5923 5924 3265 88 1740 2906 2904 4747 2902 1742 1741 1739 815 816 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 1029 1019 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere 5424 6119 5425 6118 7486 54386 10714 2237 26277 25913 57804 5111 3978 7013 65057 7014 641 6117 1763 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation 10062 7314 1213 1211 160 161 163 29116 7376 7436 6233 7316 1175 255738 1173 7311 LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis 695 10552 10787 8936 71 51517 10152 3071 10163 63916 10006 1793 5879 23191 1398 9844 3055 5594 5595 998 10093 10092 10095 10094 10097 10096 60 10810 2268 7454 7456 5747 917 4067 147179 4620 4650 7410 4641 7525 2214 7409 4651 4690 644150 26999 10451 25 4644 10458 10109 2534 8976 55845 4627 6850 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 96%9665233 Resistance of ERBB2 KD mutants to trastuzumab 3320 55914 2064 11140 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs 5743 4056 240 246 1559 3248 2948 2053 4048 1571 1558 239 1544 1565 1543 1576 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME DATABASE ID RELEASE 96%9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 1959 3912 7003 4099 6663 5453 5454 57211 4664 4665 10413 3156 84059 4359 7402 79966 57716 4155 1595 3066 6721 5376 1605 1821 25937 3915 6597 3908 SIGNALING BY ALK%REACTOME%R-HSA-201556.5 Signaling by ALK 3065 285016 3718 5803 389658 5764 6774 2033 25942 5335 3561 4609 3091 1786 4613 3066 29126 8841 238 5295 639 5296 5290 5291 10818 3667 5777 4192 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants 5519 1452 139285 2932 5515 324 5516 5518 8312 5525 5526 5527 5528 5529 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles 8815 3159 11168 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%73854 RNA Polymerase I Promoter Clearance 8331 8337 8334 6908 8335 1107 53615 8341 11335 8342 8347 8348 8345 8850 8340 1108 2074 9219 54700 8338 85236 8349 3066 10919 8370 5440 5441 5595 4331 1022 57504 2071 9112 2966 2965 3013 2068 3065 5434 5435 8932 255626 5437 2968 2967 404672 3021 3018 902 3017 3014 474382 57459 5931 221830 8970 7343 128312 25885 54815 9014 2648 9015 94239 9013 55766 64425 7270 79101 8968 10849 30834 84172 51082 653604 9533 54145 5928 CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 96%5607764 CLEC7A (Dectin-1) signaling 5708 808 5709 1147 5530 84433 5532 3553 5700 5701 7321 5702 5704 5705 10768 4790 3708 5682 3709 5683 4792 5684 5685 841 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 4791 5694 7311 5970 5695 7314 6500 7322 3551 997 5687 10454 5688 7334 8517 7335 5689 7189 8915 64170 257397 64581 23118 9039 9040 5580 9020 3710 29108 5971 5170 9861 8454 5336 6233 7316 4772 10892 4773 10213 6885 5534 5706 23291 6850 5707 4775 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 96%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 808 5593 3320 2644 2643 4846 5805 207 1719 6697 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%9022692 Regulation of MECP2 expression and activity 808 817 818 3065 2874 192670 5566 27161 9212 25942 28996 26523 6907 27327 79718 23112 57690 3066 192669 3064 8841 9611 2290 814 3930 9612 815 816 4343 NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway 835 1147 5603 834 837 83737 841 14 329 3654 8767 330 3551 842 10454 7334 8517 7335 7189 64127 5608 64170 257397 1540 23118 7128 1432 10392 6300 3656 6885 5600 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020958 Interleukin-21 signaling 3716 6775 6777 6776 3718 59067 3561 6772 6774 50615 COBALAMIN (CBL) METABOLISM%REACTOME%R-HSA-9759218.2 Cobalamin (Cbl) metabolism 4548 326625 27249 4552 25974 4594 166785 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses 23636 9972 9631 7175 11097 23511 3105 567 8086 8021 53371 8480 10762 8678 8767 10454 7334 7335 7187 9641 7189 64127 257397 5781 23118 10392 3656 5777 9636 64135 3442 3441 3440 23586 80143 84282 57506 91662 22863 3452 6772 3451 3449 3448 3446 3445 3444 3320 3443 7706 348995 3838 57122 55746 23765 3716 89122 23279 79023 51284 51311 6396 4153 9868 1387 114548 5648 6885 5903 1147 340061 7297 3665 7097 7096 6773 112744 3326 3454 79902 3654 84818 3107 3106 3134 3551 3133 9908 8517 10146 3135 6441 3456 7555 29110 51128 3661 23367 9871 9632 10427 5289 10802 9883 3605 10484 129401 26007 9688 30849 23225 4927 23165 55706 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate 22845 79947 4597 79644 116150 207063 57171 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-HSA-5607763.3 CLEC7A (Dectin-1) induces NFAT activation 808 5530 3710 5532 10768 3708 3709 4772 4773 5534 4775 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels 55970 3760 3761 2550 3759 3772 54331 59345 3762 3763 3765 3766 3768 2793 2792 2791 3773 2790 2788 2787 2782 2786 2785 2784 2783 10681 51764 94235 9568 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 96%69002 DNA Replication Pre-Initiation 8331 54107 8337 8334 51529 7321 8335 8881 64682 25906 11065 8697 7324 84515 5000 10393 29945 8341 5001 27338 23594 119504 8342 23595 29882 4998 8347 4999 8348 246184 8345 996 51434 51433 8340 23649 8338 5422 85236 8349 5557 5558 1017 29935 10926 81620 51343 51053 55388 8370 23633 3013 255626 3021 3018 3017 3014 3837 474382 8970 128312 55766 8317 8968 653604 9861 6233 7316 10213 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 4172 5714 4173 7979 4174 5690 4175 5691 4176 5692 5693 5694 8318 7311 4171 5695 7314 5687 5688 5689 56655 990 6117 94239 6119 6118 5426 5427 54145 3836 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 2249 2247 2261 2246 8823 2254 8817 26281 8074 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 1855 440193 1857 1856 CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli 8331 8337 8334 8335 2353 192670 8341 8342 8347 8348 8345 26523 8340 5175 2475 8338 85236 8349 5034 23112 57690 2932 192669 79109 3791 2034 213 8370 5753 2146 4343 3013 84699 55615 255626 5567 5568 3417 5563 6772 6774 3021 3018 3017 3014 64223 8131 201163 474382 55846 23334 10000 440275 8970 144577 128312 23677 84219 27327 10641 81929 55364 55766 652968 96459 8726 729438 8968 79726 10985 154743 9681 57600 54468 11133 207 208 653604 7415 23512 10963 5928 2534 467 118 10130 58477 6745 10897 2081 153222 90993 64764 9797 4189 440 10106 1388 1663 148327 9709 6921 7466 3068 55062 3339 6923 10954 1639 9695 30827 1054 2697 116138 7709 56005 27230 81501 55033 1200 2134 6734 2137 10488 64061 2135 11015 27102 22809 6888 2767 7157 7086 2776 9883 129401 9688 23225 4927 5226 3159 25828 23165 55706 23636 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 24145 6230 6231 6234 9349 6235 6191 6193 6192 6194 51121 115209 6227 6229 6228 11224 9641 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 3309 6136 811 6128 4363 6129 6142 6141 6144 6143 6146 6147 3304 6139 6138 6152 6155 6154 6157 6156 6159 6158 59284 3320 2197 23521 140032 2931 5611 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 6175 5573 9045 6210 6176 6171 6170 9451 6173 51065 6205 6204 6207 6206 6209 6208 6188 6187 6223 6189 538 6222 6224 6181 6218 6217 11331 30968 10730 100137049 59341 4493 4494 4495 4496 4499 4489 4501 4502 4504 84560 4490 5393 11340 22894 23016 8570 23404 5073 3688 51010 54512 51013 56915 118460 3336 7322 6195 2168 3397 5520 9780 302 3685 5747 8453 5576 2938 2324 3326 2673 55004 8649 64121 58528 10542 389541 8912 28956 57521 10670 64344 6009 153129 84335 8878 37 10325 3312 51360 6667 4800 4801 4802 4520 8720 54205 5029 3552 1670 3313 9812 27429 55466 3301 4899 9361 84962 815 816 6737 817 818 139285 5566 6197 6196 8535 8091 23043 26277 79813 25913 7290 7295 3490 57634 3009 3008 3007 3006 3005 648 4217 4194 8550 6015 3024 25842 890 4193 1912 1911 10919 5608 54386 5609 80012 84733 6416 5601 5602 5606 2077 8290 9820 23523 27287 6045 7013 65057 7014 5598 1032 1031 9817 23135 1030 1029 3569 2114 2113 50488 9448 23466 3456 3576 5599 8900 29855 1051 57332 7428 374 55738 596 5154 1950 598 1915 1536 1535 4688 4689 81631 653361 1965 8894 1968 64839 23657 111 112 113 114 115 5027 5575 114548 5577 196883 107 51726 108 109 10525 4512 4513 4514 55666 3678 10628 847 84701 9532 7353 10294 3484 10013 405 1465 6818 6620 55860 51164 10671 93661 84516 341947 25942 5584 7422 9612 4000 475 6347 493869 140809 79400 4199 10072 30001 81502 4097 10061 257202 79594 1728 9588 2940 10935 27244 26043 2950 644 645 84181 55620 6647 2729 9861 6649 8454 2730 8714 6233 318 7316 2880 10540 2878 10213 2876 10587 2882 5706 9973 5707 343 468 5708 5709 1147 5700 5701 5702 5704 5705 4790 5682 5683 4792 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 7296 5693 5694 10121 7311 5970 5695 7314 6500 3551 5687 5688 8517 5689 1003 5241 6256 5465 2099 6095 367 2908 4306 2877 472 672 3306 3305 6117 6119 79728 6118 1327 11258 1329 22926 10111 1340 4361 1337 4683 10524 1339 545 1351 1350 51529 1349 7321 8881 64682 1347 25906 1346 11065 1345 8697 7324 10393 29945 27338 119504 29882 246184 996 51434 51433 1499 125965 9261 1432 5594 5595 6464 5600 7867 3329 96764 113235 5770 2033 3043 23643 3162 3040 613227 571 6907 80205 335 51266 8648 338 10891 4862 10370 7514 7975 10499 10498 79718 84447 6604 4208 4209 7099 167227 9575 4780 8204 64784 4697 8841 9611 23411 50507 9572 200186 1387 23373 23054 1386 5469 85441 406 10743 2289 10424 2288 808 84290 5052 7001 4001 7531 10728 824 826 6648 2309 3725 4851 9978 2793 2792 2791 2790 23410 2788 2787 2786 2785 2784 2783 51764 94235 6696 55970 10266 133 54331 59345 7323 781 782 783 784 2782 25 2778 10681 10203 8452 126374 112399 112398 8994 55662 54583 7027 1021 1019 1017 1871 898 1870 51343 830 6502 832 9134 1027 1026 7029 829 1869 5925 6232 4323 8655 9377 23645 348995 5580 1649 57122 51143 55746 83667 23279 79023 9167 7184 6396 10808 3281 1781 27000 26353 1780 259217 1410 3297 1778 116835 7266 51182 573 2539 4846 3337 6767 51501 2887 57805 9531 22824 6782 1783 7414 9530 3310 91582 5903 9529 10049 3308 5519 3690 79094 7094 140735 5515 5518 22872 79902 5526 245972 245973 3163 155066 9114 51606 10113 9550 9570 523 9429 525 526 527 528 529 8992 90423 127124 51382 533 534 10312 9296 1460 1459 1457 4609 5931 10413 3091 94239 25994 2056 768 5586 253260 57761 5296 5290 5170 5291 5293 54145 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956522 OTC variants cause OTC deficiency 5009 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%R-HSA-180585.3 Vif-mediated degradation of APOBEC3G 5708 5709 8065 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 6921 5695 9978 7314 6923 5687 5688 5689 9861 6233 7316 10213 5706 5707 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-6807062.4 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) 7108 6720 1595 1718 6721 6307 50814 51478 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression 7004 7003 2626 7005 1490 4878 6910 8463 204851 1482 25937 28996 8850 10413 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 96%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 5708 5709 5700 51529 5701 7321 5702 5704 8881 64682 5705 25906 11065 5682 8697 5683 7324 5684 10393 29945 27338 5685 119504 9212 6790 5686 29882 5717 5718 246184 5719 996 11047 51434 5713 51433 5347 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 5689 51343 6502 5925 991 9861 9232 6233 7316 10213 5706 5707 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis 3615 158 122622 159 3614 10606 5471 2618 5198 8833 471 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 96%8851680 Butyrophilin (BTN) family interactions 11119 11118 696 30835 56244 11120 10385 7498 153579 10384 79908 5493 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 96%5610787 Hedgehog 'off' state 5708 5709 5700 5701 5702 107 5704 108 5705 109 5682 5683 8650 5566 5684 83737 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 57539 5695 9978 7314 6500 5687 5688 2932 5689 55081 55764 8100 51684 5567 5568 11127 6608 57728 111 112 113 114 115 2737 8481 2736 7289 374654 80199 9742 55811 23432 23322 2735 27152 1452 79659 5575 54903 5573 51098 9861 5577 2778 8454 6233 7316 5576 10213 5706 196883 79809 5727 5707 26160 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 96%168276 NS1 Mediated Effects on Host Pathways 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 10762 348995 3837 3838 3839 79902 57122 5610 55746 8106 10898 23279 79023 2633 402569 3840 3841 6396 197259 9883 129401 9688 23225 3836 4927 23165 9636 55706 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 96%8942233 Intestinal infectious diseases 2984 79849 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467348.4 Truncations of AMER1 destabilize the destruction complex 5519 1452 139285 2932 5515 324 5516 5518 8312 5525 5526 5527 5528 5529 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 808 2324 84290 107 108 109 7094 5566 824 826 24145 5029 5175 2475 1499 2793 2792 2791 2790 1003 79109 3791 2788 2787 2786 2785 2784 2783 51764 4323 94235 55970 55615 5567 10266 5568 111 133 54331 112 113 114 59345 115 64223 9780 2767 59341 5586 253260 5575 207 5573 2776 5296 2782 5290 5170 5577 5291 2778 5293 4846 5576 2534 10681 196883 7414 10203 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport 57127 51458 6005 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression 8331 8337 8334 6908 8335 8341 8342 8347 8348 8345 8850 8340 2074 8338 85236 8349 9188 23451 2932 8370 5440 5441 7913 3013 5434 5435 255626 5437 3021 3018 2033 3017 60 3014 474382 221830 8970 128312 25885 9014 2648 9015 94239 9013 55766 64425 10514 79101 8968 10849 8467 30834 9031 84172 51082 653604 9533 54145 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI 1591 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells 5087 6299 2516 4087 4089 63978 27022 84891 79727 6774 2034 6997 2247 6657 5460 57167 7547 79923 2041 64344 9314 55211 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9818749 Regulation of NFE2L2 gene expression 5970 7975 1387 4851 2033 4609 4790 4780 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 4851 7314 9148 28514 182 54492 57534 102 54567 6868 142678 3714 6233 7316 7311 DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) 10599 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196854 Metabolism of vitamins and cofactors 2350 6697 57107 56997 56910 2644 2643 84842 79934 51004 51805 26119 57017 338328 5805 23590 5406 81693 10229 27235 1208 51117 84274 4023 8029 336 683 337 3949 344 345 151056 3417 113235 335 338 4907 10135 207 1719 53630 55937 6383 10082 6385 808 6382 221914 9672 9227 2239 83875 3339 2262 5091 2817 7274 5826 26020 57016 6513 2719 55788 348 4552 9446 4837 29967 4548 1645 1109 6948 31 32 6515 375790 7276 5646 5096 4594 4363 166785 8644 5095 326625 27249 25974 51109 5950 3320 5948 54956 143 56965 83666 79668 5947 84875 54625 5593 25902 6470 83594 55328 23057 160428 9962 2694 9963 8566 1727 200895 1528 60386 441024 952 4522 4524 4846 6947 54 160728 80308 29914 23475 79581 128240 54981 55034 64087 5644 10840 55163 154807 56922 79001 27010 4338 55739 1504 349565 133686 55065 8034 3141 55191 8875 440387 8876 5167 27231 5168 10243 79178 8884 5169 316 2194 92014 80025 80704 284439 9390 93100 119391 254552 80347 64802 51293 53354 686 79877 79646 7804 10588 60496 65220 55229 6573 79717 113278 51248 27304 60490 81034 10797 55312 10560 48 54884 4036 6472 4035 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9703009 tamatinib-resistant FLT3 mutants 2322 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated 1499 5519 1452 139285 2932 5515 324 5516 5518 8312 5525 5526 5527 5528 5529 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function 9227 5947 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%71737 Pyrophosphate hydrolysis 64077 5464 27068 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 96%3296482 Defects in vitamin and cofactor metabolism 5095 64087 8029 4548 56922 326625 6948 27249 25974 55788 31 3141 5091 2694 51293 686 5826 4552 81693 5096 4594 166785 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria 808 7314 11045 4072 7322 2633 837 163351 2634 3043 115361 3040 6233 7316 7311 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5682910 LGI-ADAM interactions 27092 112755 4185 9211 163175 55203 8745 203190 53616 6804 10369 10368 59283 1742 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9715370 Miro GTPase Cycle 55669 66008 89941 5910 9927 22906 55288 80179 TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling 841 8795 8793 8743 843 8797 8837 8772 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression 2155 96764 6907 80205 8648 4862 5054 10499 10498 79718 6604 551 10135 9575 8553 28999 56938 6256 25819 1387 79365 5465 23054 5469 85441 406 CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 96%5690714 CD22 mediated BCR regulation 4067 973 974 933 5777 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors 7529 7532 7534 4303 2309 10971 2308 10000 207 208 2810 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 96%5578768 Physiological factors 2626 4311 4878 6910 204851 1482 25937 4880 28996 8850 4881 4882 10699 1066 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764302 Regulation of CDH19 Expression and Function 1500 6663 1499 3728 28513 1495 80149 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 96%75205 Dissolution of Fibrin Clot 5054 5340 5055 5345 5329 5270 6281 5271 302 5269 5327 5328 3273 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948011 CASP5 inflammasome assembly 838 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 96%211736 Stimulation of the cell death response by PAK-2p34 836 5062 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-HSA-1606322.3 ZBP1(DAI) mediated induction of type I IFNs 5970 1147 7098 3551 8517 4790 4792 148022 4793 8737 28512 11035 29110 147945 3661 23220 81030 28511 1660 4791 4615 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME DATABASE ID RELEASE 96%9636467 Blockage of phagosome acidification 51606 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 96%9007101 Rab regulation of trafficking 7879 57589 51560 81631 51209 5870 1121 9827 374403 9367 11021 9363 84958 23062 57465 23163 51762 79735 27342 83874 5874 83452 4943 11345 8408 9135 23637 10133 729873 338382 64786 125058 9230 54662 26088 26000 55357 51256 57533 5867 11337 57679 5873 5878 5868 10000 5869 207 208 117177 81846 4218 7531 79090 6399 5861 22878 22879 221960 79890 2665 80006 126003 2664 25782 23682 57706 58485 10260 6764 11031 23258 9909 51693 6305 79961 116442 122553 84315 60684 7248 23011 27095 10981 5866 84079 160518 81876 163259 83696 126432 22930 22898 22931 54453 7249 55667 51399 27147 3257 54734 7109 51622 79958 128637 259173 89781 201627 9610 163486 414918 201475 1122 51112 8766 5864 26130 10890 5872 51552 382 DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 96%9845622 Defective VWF binding to collagen type I 7450 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding 2793 2792 2791 2790 908 113457 6950 898 7203 7280 2788 26272 2787 2786 83752 9134 26234 10693 2785 6468 10574 2784 10376 10694 10576 2783 2629 10575 51764 80086 26190 94235 26270 9630 51807 6000 55970 22803 8787 7411 10381 10383 8786 10382 55294 112714 6774 55135 9628 7846 60 84790 54331 10471 1460 5201 1459 5202 59345 1457 6499 5082 84617 11328 10238 2767 26330 10517 347733 84261 2769 7277 7157 22948 7278 63971 26985 26224 81027 79861 8841 54461 2776 10528 5203 5204 2782 8877 10564 10681 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME%R-HSA-5579027.5 Defective CYP27B1 causes VDDR1B 120227 BASIGIN INTERACTIONS%REACTOME%R-HSA-210991.3 Basigin interactions 5478 6520 3675 4312 3655 4099 6566 8140 23657 682 56301 11136 3897 3688 857 23539 9123 481 23428 482 483 6693 9056 23759 9057 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 96%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 3024 7157 25842 4001 29855 8091 7290 23523 57634 3009 5925 3008 3007 3006 3159 3005 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654706 FRS-mediated FGFR3 signaling 4893 6654 2254 3265 5781 8074 2249 2247 10817 2246 8823 10818 8817 26281 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER 54107 7874 6917 3978 2074 7311 9978 7314 56949 1161 5440 5441 4331 1022 2071 2966 2965 2068 9716 5434 3980 5435 5436 5437 5981 7515 5438 5982 5439 5983 2968 2967 91603 404672 56655 5430 57654 5431 5432 5433 902 8451 8450 5111 1642 6117 5984 5985 5424 6119 5425 10450 6118 5426 5427 10714 27339 51426 57804 6233 7316 57461 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases 8497 8499 11141 114798 84631 94030 139065 5802 8495 26050 8496 8500 8541 5792 4916 22865 5789 26280 84189 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores 80152 5903 2491 5519 332 55143 699 11243 140735 3619 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 79902 5347 5525 5526 55839 5527 5528 5529 54908 6232 8655 25909 8379 9183 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 348995 348235 5048 23421 57122 220134 57082 57405 147841 51143 6249 7514 55746 4085 64105 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 96%426048 Arachidonate production from DAG 26090 57406 221955 11343 747 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding 51807 7411 10381 10383 10382 112714 7846 60 84790 10471 5201 5202 84617 347733 7277 22948 7278 81027 908 79861 113457 6950 7203 7280 5203 5204 10693 10574 10376 10694 10576 10575 80086 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670095.3 Inhibition of DNA recombination at telomere 8331 3013 8337 5434 8334 5435 5436 8335 5437 255626 5438 5439 5430 5431 8341 5432 3021 5433 3018 8342 3017 8347 26277 3014 8348 8345 25913 8340 474382 8970 128312 8338 85236 8349 94239 55766 54386 1616 8370 8290 5440 546 5441 54145 7013 65057 7014 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression 8331 23378 3013 8337 8334 6908 8335 255626 8341 3021 3018 8342 3017 8347 3014 8348 8345 6839 8340 474382 8970 128312 8338 9014 85236 9015 8349 9013 94239 55766 79101 8968 23411 653604 8370 54145 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones 1734 15 1733 5409 121278 389434 7054 438 857 1644 90527 1621 6528 1735 7166 7252 50506 53905 405753 51061 1081 7173 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 4067 3815 4893 6654 6772 7525 3265 6774 5295 5296 6777 6776 8503 5290 3932 3717 2534 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%438066 Unblocking of NMDA receptors, glutamate binding and activation 808 2892 817 2890 818 2893 88 1740 2906 2891 2905 2904 2903 4747 2902 1742 1741 1739 815 816 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660514 Synthesis of PIPs at the Golgi membrane 55300 5297 55697 22908 5289 375 5288 93492 55361 56623 377 30849 5298 9896 5286 200576 4952 7179 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema 3818 2161 2147 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) 50835 50834 50837 50836 50839 50838 5726 2550 50840 259289 259287 259286 259285 259294 222545 259293 259292 259290 259296 259295 353164 2911 2918 846 2917 2916 2915 2914 2913 2912 338398 83756 54429 80835 50831 80834 50833 9568 50832 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.4 Anti-inflammatory response favouring Leishmania parasite infection 808 2770 2781 2773 107 108 10768 109 3708 3709 5566 5045 2793 2792 2791 2790 2788 2787 1432 2786 2785 3055 2784 2783 51764 94235 3569 55970 5567 5568 57105 111 54331 112 5335 113 114 59345 115 2268 2678 917 64174 4067 3710 136 2687 2209 346562 5575 6868 7525 1800 10800 5573 2214 2212 2782 5577 2778 5336 5613 79651 5576 10769 9332 2534 10681 3586 196883 4627 6850 2771 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 96%164939 Nef mediated downregulation of CD28 cell surface expression 940 1173 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling 3718 5566 29760 7006 3561 3635 3636 3716 4067 867 3563 3560 6654 1437 1439 1438 7525 3568 5781 3567 2889 7409 3562 5295 1399 5296 6777 3559 6776 1398 8503 3558 5290 3055 5291 5293 7534 6464 3717 2534 9846 5777 6850 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 96%8981373 Intestinal hexose absorption 6523 6248 6514 6518 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 96%2871809 FCERI mediated Ca+2 mobilization 808 695 5530 5532 7294 10768 3708 3709 5335 7006 4067 3710 9402 7410 6654 7409 10451 5336 3937 4772 4773 5534 3702 6850 4775 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 96%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) 340024 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-HSA-8850843.6 Phosphate bond hydrolysis by NTPDase proteins 57089 954 955 953 956 377841 957 9583 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping 1855 7474 5879 10811 1535 27035 5599 1857 3725 1856 8324 124056 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 96%8939256 RUNX1 regulates transcription of genes involved in WNT signaling 50943 2099 8312 861 84870 865 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation 4194 7314 91875 7157 4193 10919 11200 472 26013 10419 2033 79813 6233 7316 133383 133746 56950 7311 387893 BINDING AND ENTRY OF HIV VIRION%REACTOME%R-HSA-173107.5 Binding and entry of HIV virion 5478 920 7852 1234 ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO 132884 2121 1452 23288 2622 84455 50937 408 50846 409 91653 2619 11127 6608 3549 156 6469 5727 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins 364 366 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 96%9660821 ADORA2B mediated anti-inflammatory cytokines production 2770 3569 2781 55970 2773 107 5567 108 109 5568 5566 111 54331 112 113 114 59345 115 136 2793 2792 346562 2791 5575 2790 5573 2788 2787 2782 2786 2785 5577 2778 2784 5613 5576 2783 10681 51764 196883 94235 2771 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 4851 28514 182 102 54567 6868 3714 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020558 Interleukin-2 signaling 3716 6777 3559 6776 3558 3932 3718 3561 3560 6464 2185 6850 MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis 841 197259 8737 11035 RAC2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013404 RAC2 GTPase cycle 9341 55971 23092 57580 143872 8826 396 50619 4810 55619 10787 85360 5062 7879 10152 10298 29 3998 29127 9710 613 81839 51347 26050 3071 10163 28964 3688 653361 23075 2010 23344 55114 143098 10006 23141 1794 1793 4983 8987 55789 4162 7112 80728 9217 4168 9732 23191 55004 81624 23592 11135 1829 5880 1969 55914 3930 998 5338 4580 25813 7037 7074 1795 857 51566 7410 23580 7409 5295 5296 5058 8503 5290 10451 1536 1535 7444 10424 7204 9743 9815 2909 4688 55845 57584 4689 392 WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL 1855 8395 1454 1460 1459 1457 1857 1856 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 96%211163 AKT-mediated inactivation of FOXO1A 2308 10000 207 208 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions 8331 8337 440689 8334 721 8335 9382 8678 8341 8342 8347 8348 8345 8340 2475 8338 85236 1499 8349 79109 81608 8370 3013 22938 64135 55615 5824 255626 10421 57506 22863 285755 57794 22826 3018 22827 3017 7706 4318 23643 6993 11100 10262 64223 54883 335 11325 10236 55749 8970 128312 23524 10450 57703 8968 7099 54463 53938 24148 653604 23020 85313 9879 9410 9416 10181 51340 6383 5093 10082 5094 6385 51593 6886 57461 84844 1655 22916 6382 1993 27238 3183 4686 8175 51729 6773 7431 221914 9672 80273 51503 27316 23601 55696 3326 10992 2239 79869 5725 10523 4670 988 8189 11051 10978 6627 1479 6629 51692 3339 220988 1478 1477 23283 23450 10914 53981 23451 51585 56949 5546 29894 55339 6638 2262 10594 550 2817 5356 3178 57521 3181 3188 3187 3185 3184 9716 3191 2719 3190 51639 8896 3312 51645 10084 10291 8449 10283 8241 23350 10286 10285 9343 56259 10946 5289 10949 10907 29959 1654 27339 1665 84991 2521 83443 30849 375790 10015 8737 23168 79577 80349 10898 123169 9646 54623 9641 1616 3192 6141 2147 4904 3320 317772 92815 85235 8106 8969 221613 4153 712 716 57551 23352 1660 815 816 115004 817 818 340061 4792 4793 2194 9785 6430 6432 6431 10250 51362 199746 7082 55763 6427 6426 1994 5440 6429 5441 8729 6428 10189 7329 2963 2962 8683 5434 5435 9775 5436 5437 9295 5438 10921 5439 11338 5430 1191 5431 5432 7307 722 5433 725 4751 253260 6632 6628 6634 6633 6636 6635 6637 7448 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) 9197 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription 7004 864 7003 25937 7005 1490 10413 8463 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 2353 8651 841 7186 8767 4615 4791 57162 84166 4205 10454 7334 6285 7335 929 6288 11274 7189 64127 6283 3146 51295 257397 51135 9261 4214 23118 9683 9684 6195 1432 6279 10392 6280 28512 79155 57161 79671 5594 177 5595 121457 246330 28511 59307 3656 9097 466 5600 51231 114609 1849 7867 948 1848 11213 1846 6271 1845 5604 23643 4208 7099 1386 8454 6233 7316 1326 6885 2244 2266 23291 80216 92610 695 1147 5519 2243 4790 7097 7096 351 4792 5515 6197 6196 4793 5516 5518 8945 3725 3654 5528 7311 5970 7314 6500 3551 8517 5608 5609 6416 5601 5602 5606 10333 5598 2002 5599 7157 9252 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling 3983 1793 5879 6714 9423 22885 84448 4690 1630 7204 998 8976 5747 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) 1356 30061 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%391903 Eicosanoid ligand-binding receptors 5729 5731 5737 5739 5732 10800 56413 5733 5734 6915 57105 11251 2840 165140 1241 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME%R-HSA-9664424.3 Cell recruitment (pro-inflammatory response) 3553 9051 834 718 4790 10628 4210 5025 3326 3162 7295 3606 4791 5027 79792 5970 10910 1511 4907 3552 29108 114548 953 957 719 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction 29766 89 7431 7125 8557 29767 7140 4606 4607 29765 1674 4621 7139 4624 4604 1756 4626 4703 7134 7111 7136 7135 7138 4632 4633 7169 4634 7168 4635 7137 7273 88 7170 7171 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-HSA-73933.4 Resolution of Abasic Sites (AP sites) 54107 3980 142 5423 328 5981 7515 5982 8505 5983 54936 10038 56655 4350 3978 5111 11284 6117 5984 5985 5424 6119 5425 6118 5426 5427 10714 2237 57804 8930 23583 252969 4968 79661 6996 4913 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4615885 SUMOylation of DNA replication proteins 23636 6613 9972 5903 9631 7175 332 11097 10401 55143 23511 8086 8021 53371 8480 10762 3619 9212 6790 348995 5111 79902 57122 55746 23279 79023 6396 7341 7153 7155 7150 9883 129401 9688 23225 4927 51588 5905 6612 23165 55706 7329 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 96%437239 Recycling pathway of L1 8650 6197 24137 6196 3897 1759 1785 5962 1808 6456 4478 8986 285643 1213 1211 160 161 163 6195 9252 26052 5594 27330 7430 1175 1173 57698 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events 6872 22916 6874 6873 6908 4686 6827 6749 4298 6881 6830 6880 27125 6883 55840 6882 6884 4300 8148 85403 9150 55677 6917 1025 51497 11198 6875 6878 83860 6877 8812 23168 2959 2958 79577 6879 2957 25920 80349 54457 2961 2960 51224 6921 123169 6924 7936 9646 6923 7469 138474 904 905 54623 5440 5441 4331 1022 2071 6829 2966 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 8178 129685 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora 378884 7314 7957 6233 2997 7316 5507 2992 7311 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%R-HSA-168333.5 NEP NS2 Interacts with the Cellular Export Machinery 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 10762 348995 79902 57122 7514 55746 23279 79023 6396 5901 9883 129401 9688 23225 4927 23165 55706 NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription 2324 2648 59 4851 22938 23462 4088 84441 10046 388585 3280 23493 2033 1387 4853 8850 3516 4855 9794 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 96%8849474 PTK6 Activates STAT3 55620 5753 6774 9021 SIGNALING BY RNF43 MUTANTS%REACTOME%R-HSA-5340588.4 Signaling by RNF43 mutants 89780 8325 4040 54894 7855 4041 8323 8322 INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME DATABASE ID RELEASE 96%5659898 Intestinal saccharidase deficiencies 3938 6476 CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 96%110331 Cleavage of the damaged purine 8331 3013 8337 8334 8335 255626 8341 3018 8342 3017 8347 26277 3014 8348 8345 25913 4350 8340 474382 8970 128312 8338 85236 8349 94239 55766 54386 8370 8290 55247 54145 7013 65057 4968 7014 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 96%2243919 Crosslinking of collagen fibrils 84171 4015 4016 4017 84695 7093 5118 7092 649 7837 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 96%9918432 Maturation of DENV proteins 283208 51726 100128731 4836 10525 10527 8813 8818 7311 5034 7314 6185 6184 746 1603 7341 54344 10965 3309 811 7329 821 84061 3837 9789 3838 7991 3839 5611 90701 335 201595 3703 2923 8974 7514 5593 54431 1650 22937 402569 3840 3841 28972 60559 5033 6233 7316 58505 3836 23478 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling 5708 5709 1147 84433 5700 5701 7321 5702 5704 5705 4790 5682 5683 4792 5684 5685 5686 5717 5718 50852 5719 8945 11047 5713 5714 7979 5690 5691 5692 8767 3635 5693 5694 7311 5970 5695 7314 6500 7322 3551 997 5728 5687 5688 7334 8517 7335 5689 5588 7189 8915 23118 3123 3122 3120 3119 3118 3115 3113 3127 3126 3125 3932 915 916 917 920 5295 5296 5290 5170 9861 5291 8454 6233 7316 10892 10213 6885 5706 23291 5707 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME DATABASE ID RELEASE 96%164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 8907 920 130340 3105 160 567 10053 161 1174 8905 162 163 375 55690 164 51606 3932 926 940 1175 1173 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription 1107 53615 8535 23186 1108 9219 3725 2475 648 6015 1912 1911 3066 55004 80012 8649 84733 6591 64121 58528 6045 5594 10542 5595 389541 28956 2146 5978 57521 57504 10670 6009 9112 5468 153129 10325 3065 23466 57332 2122 64223 57459 5931 54815 8726 7157 1958 51564 8841 10014 1386 7101 57167 23512 1822 5928 84232 23028 6615 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 9341 55860 23647 51164 22836 10671 8774 636 8775 23299 3482 93661 5050 79571 9267 22796 84516 9342 5049 9382 57589 9265 10139 9266 27128 51560 143187 10652 250 10618 9950 60592 29127 27333 51209 25839 5870 9712 22818 26286 90196 10228 122830 22820 84316 83548 400 63908 57511 60560 10466 9827 9367 8674 8677 8675 339122 6293 9585 2800 51542 55083 23046 84342 55605 4122 738 91949 113220 83452 3833 2803 7110 3834 90990 55275 55850 10244 9648 23095 10749 60561 55614 6811 830 146909 832 11316 6836 55582 23303 124602 53407 64147 221458 829 662 51594 9609 8398 547 8655 3798 3799 9183 1062 347517 10226 11014 2589 5321 5048 51143 9276 4124 84364 1315 11311 1314 1781 22920 1780 1778 2590 81930 84643 3796 10540 64837 1783 26153 147700 10112 26958 9493 3831 3832 3835 378 140735 51014 56992 24137 23423 89953 11004 57134 5861 4121 51272 10905 377 9371 10972 9554 10121 25782 285643 1639 372 81876 381 10959 22930 9527 22931 11015 3797 9570 8729 54734 54732 56894 51226 9321 4074 375 11127 55738 27314 4905 11258 10945 1523 ASPIRIN ADME%REACTOME%R-HSA-9749641.4 Aspirin ADME 7364 7367 7366 54600 54578 54577 54576 6566 574537 682 54579 167127 10720 1571 590 1558 1557 1565 1576 10249 123876 1559 341392 219970 8824 92292 54988 389396 348158 54659 213 10941 133688 8714 54490 79799 54658 1066 54657 7363 7365 1244 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%156711 Polo-like kinase mediated events 9133 1063 2305 993 7465 2033 286826 891 995 132660 91750 55957 5347 5928 9088 4605 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE 56261 8605 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702636.2 tandutinib-resistant FLT3 mutants 2322 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-HSA-3134975.4 Regulation of innate immune responses to cytosolic DNA 81844 7314 11277 51428 340061 22954 29110 6233 147945 3661 7316 23220 81030 7311 6737 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 96%5578996 Defective CYP27A1 causes CTX 1593 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function 145226 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159227 Transport of the SLBP independent Mature mRNA 23636 22916 9972 5903 9631 7175 10482 11097 4686 23511 8086 8021 53371 8480 10762 348995 79902 57122 55746 23279 79023 6396 1977 9883 129401 9688 23225 4927 23165 10189 55706 PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis 5634 221823 5631 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-HSA-210745.3 Regulation of gene expression in beta cells 3630 6514 2308 207 208 5080 3174 6927 4821 4825 3170 4760 3651 389692 3171 222546 2645 10000 3375 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 1605 55624 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 5209 5519 5567 5210 5568 5566 5515 5528 5207 5516 5208 5518 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 96%1474244 Extracellular matrix organization 91522 11131 3910 1297 23473 3911 1296 11132 3912 1295 4317 7412 1294 4312 4319 1293 5654 1292 4324 1291 4326 1290 4327 7177 1305 85007 1303 6650 1302 1088 1301 1289 147968 26254 1300 1288 50859 1287 780 85301 4237 5155 4238 1308 4239 1307 84570 2199 3688 2192 1306 388743 4921 80274 8754 5175 8076 3817 64386 101 5034 999 2 4316 5663 3791 7087 3681 3682 3684 10491 23385 23127 22801 10536 3695 871 3371 83700 5351 961 5352 3687 8985 55214 3689 64175 3386 26577 58494 3381 5118 79709 1311 2200 5340 6678 4318 3685 9644 8974 1511 4060 5479 5033 1605 2331 8728 1509 6383 4313 6385 6382 84290 283208 9672 5339 831 823 960 824 826 87 3680 176 5045 3339 3693 3683 4684 6696 3674 3676 3678 8515 682 9510 1278 1277 4322 9507 140766 9508 9509 54829 8785 4146 7143 4593 7148 63923 1834 1404 56999 8573 2247 4038 8751 11096 8038 11095 170690 170692 375790 3691 650 3672 3673 22795 3675 3655 4811 3679 1462 1215 63827 1634 7040 633 7402 1463 1991 59277 7276 1758 1821 5645 7042 655 4323 4314 4325 7077 7076 4148 7043 4052 4053 4054 3696 8425 3694 137868 8516 1756 6645 1838 1837 6641 5578 6443 6640 5054 6442 6445 6444 8082 54221 8910 1520 1508 7093 7092 649 2244 2266 5644 3818 3690 2243 1504 440387 7057 27302 1514 1513 836 1515 51399 652 5154 634 7837 9378 84171 4015 4016 4017 84695 50848 102 5802 10893 6868 92291 10516 50509 84467 1286 2202 1285 2201 256076 30008 1284 10753 1282 3385 8200 1281 3384 222663 169044 825 1280 827 81578 3383 80781 440854 3913 9313 3914 255631 726 3915 1299 2335 2006 1310 57642 977 3918 284217 4680 1298 5650 10319 340267 7373 4320 3908 131873 4321 3909 7448 164656 136227 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%109703 PKB-mediated events 5140 208 DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) 60482 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis 7314 7957 8908 7360 5236 378884 6233 2998 2997 7316 2632 5507 2992 7311 SENSORY PERCEPTION OF SALTY TASTE%REACTOME DATABASE ID RELEASE 96%9730628 Sensory perception of salty taste 255022 6337 6339 6338 6340 119395 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions 1297 2668 1293 1292 1291 775 2675 6900 5621 5623 1287 64096 2674 779 1463 8128 1286 1285 782 256076 783 1284 784 1282 785 7903 776 4902 1299 8912 8913 8911 1298 9048 4684 131873 375790 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall 7010 3675 284 4312 3655 1088 5197 7056 3688 10544 8795 57126 5196 1048 5175 7441 8797 440533 7040 3512 914 5670 5671 5672 5673 6401 90952 5675 140885 285 4973 2888 51378 5669 4893 5680 6654 8832 29802 3265 5781 23428 1084 5676 6402 3684 2621 5678 6404 1525 2734 83700 3543 961 83953 3687 120425 3689 4267 10461 2995 58494 2994 962 5627 6464 6403 2993 965 5777 9046 54210 55423 9056 83692 9057 51744 5624 6520 4072 8140 2147 23657 56301 11136 3932 8793 3685 338 857 4282 2886 481 7525 482 483 6383 2534 6385 5478 6382 3690 4099 972 9672 3897 960 3635 3683 2817 6693 23759 3676 3678 6566 9463 682 5335 634 4067 7102 23539 50848 9123 5295 5296 5290 5291 2335 2207 4680 51206 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-HSA-174430.6 Telomere C-strand synthesis initiation 5557 5558 80169 79991 100134934 54386 26277 25913 7013 65057 7014 23649 5422 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702590 gilteritinib-resistant FLT3 mutants 2322 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 96%1483213 Synthesis of PE 85465 64900 64850 23175 55500 55224 9663 5833 23761 10390 1120 162466 1119 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%416993 Trafficking of GluR2-containing AMPA receptors 2892 2890 7102 23426 160 4905 80852 9463 2893 5582 2891 5579 5578 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%R-HSA-174437.5 Removal of the Flap Intermediate from the C-strand 5424 6119 5425 6118 7486 54386 10714 2237 26277 25913 57804 5111 7013 65057 7014 6117 1763 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 10762 5371 5987 7428 348995 79902 57122 55746 23279 79023 4193 6396 7341 9883 129401 8554 9688 23225 4927 51588 23165 55706 7329 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654720 PI-3K cascade:FGFR4 9965 2254 5781 2251 5295 8074 2249 2247 5290 2246 152831 8823 2549 2264 10818 8817 26281 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8853383 Lysosomal oligosaccharide catabolism 4123 4125 23324 4126 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport 6583 6563 8170 55244 115286 146802 85413 6248 55356 861 6581 6584 5002 6582 6580 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1793185 Chondroitin sulfate dermatan sulfate metabolism 92126 10090 55501 1462 2990 166012 337876 23553 3373 8372 112937 3074 3073 63827 1634 29940 55790 3425 79411 2720 411 3423 633 1464 1463 54480 89944 10675 55454 56548 22856 113189 50515 79586 9469 51363 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 96%167826 The fatty acid cycling model 7350 7352 7351 9016 9481 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation 6862 2260 8320 6615 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 96%209563 Axonal growth stimulation 4804 396 4803 387 CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.10 Cell-Cell communication 8331 8337 8334 8335 100128731 2185 192670 27161 8341 8342 8347 8348 1308 8345 50649 3688 26523 8340 8338 51129 2060 9459 79872 85236 1500 1499 8349 1793 5879 6185 999 23112 6184 6714 57690 140885 192669 746 81 1603 5781 6591 26508 8370 961 9844 5594 5595 2146 998 5777 55423 4343 3013 3065 255626 23607 9863 2318 6251 4868 6774 55243 7016 3021 29780 3018 6663 54751 3017 7841 8935 3014 55742 84623 84063 3611 10326 474382 55679 90701 3987 2316 3703 5747 8970 128312 27327 3716 8440 55766 1650 8726 8968 23193 7410 28972 5589 88 23411 653604 4690 2294 667 56978 8728 64403 23512 1495 27319 5928 23028 23478 80332 1006 2534 3224 8976 3609 6615 1009 7764 7408 7297 5339 6929 87 6709 5045 5046 288 6938 6711 11171 55810 687 93986 9789 1785 6667 29954 10585 60559 8573 283 3691 3655 3570 7122 329 3170 9314 5584 331 54971 3066 7305 9076 5925 6597 117581 57531 821 8289 387893 84231 1520 1508 9861 6233 7316 3717 10213 2533 5706 7020 7414 5707 5708 5709 1013 8826 5700 127544 5701 5702 5704 5705 4790 1002 5682 5683 5684 5685 9069 5686 81607 5717 5817 5718 27085 5719 5818 5819 11047 57863 5713 137075 5714 94234 7979 24146 5690 9073 5691 9071 5692 9074 5693 9075 5694 84552 7311 23705 5970 7291 283106 5695 9080 7314 53842 1010 1008 5687 4193 1007 5688 1005 1004 5689 1366 1003 1365 1364 1001 1016 1514 1015 1012 51208 3572 7490 49861 10399 54737 221935 348262 23562 253559 149461 26285 80149 5315 7750 10009 3569 84612 60436 54549 7088 25945 9159 28513 5010 9855 10686 89 7074 1460 1459 1457 9839 4609 5931 5829 1000 94239 6935 4613 50848 23396 10207 92359 64398 56288 50855 5295 5296 1488 1487 5290 5291 3728 54145 3914 58505 10979 977 3918 9743 3909 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 96%180786 Extension of Telomeres 51750 8607 23243 26277 25913 5537 3978 23649 55291 5422 5557 5558 890 1017 54386 2237 7013 65057 7014 80119 55164 54921 63922 10856 7486 80169 5981 79075 5982 79991 5983 100134934 8900 55135 1736 5111 641 6117 5984 5985 5424 55505 6119 5425 6118 7015 54433 55651 10714 57804 1763 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 96%948021 Transport to the Golgi and subsequent modification 55860 51164 2890 10671 8774 8775 1294 93661 22796 84516 2525 9382 10652 3998 25839 22818 26286 22820 83548 63908 57511 10466 3972 84342 4122 91949 6811 830 832 11316 829 8655 11070 375056 4248 11282 11014 11320 4247 4249 9486 51143 1081 6484 2683 4245 9276 4124 6480 84364 25834 1315 1453 1314 2530 6396 1781 1780 1778 10540 1783 2804 26958 3630 7039 378 140735 79090 51014 5265 23423 2801 6399 51046 57134 5861 4121 51272 23243 22870 10905 2153 4253 22872 2348 10175 5537 377 79694 10972 9554 9117 11196 64689 126003 55291 6708 10121 6709 23256 1075 58485 64377 254263 338596 25956 55014 81562 1639 286 51693 2157 287 288 122553 8615 966 51332 10342 9334 27095 6711 9331 149111 6710 8128 9919 372 81876 6712 83696 381 10959 10113 9527 90411 10282 26984 11015 9570 51399 89866 8729 79748 7109 128637 54732 10960 51226 57731 375 8703 8704 8702 2517 1522 51128 374 55738 9871 9632 10427 4905 11258 10945 10802 10484 1604 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME%R-HSA-9825892.3 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 1029 83439 1499 3065 595 1017 51176 994 891 25942 1026 5347 4233 3094 6909 6932 6934 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-HSA-198933.9 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 7412 3105 567 718 8519 3688 999 54209 7305 7087 6402 3695 1525 926 120425 3689 3386 4267 945 11314 54210 909 22914 56253 56654 89858 910 911 912 4068 3803 3804 3805 3806 374383 2209 8778 925 10666 3802 285852 23547 2214 29121 10990 4345 10871 10870 3811 27180 3812 27181 353514 114836 124599 117157 2213 342510 3820 946 3821 3824 126014 100132285 340205 10219 146894 57823 10859 11024 11027 11026 959 135250 131450 9436 9437 259197 79168 29992 5817 29990 10225 89790 5819 4277 114132 51348 11126 11006 339390 100131439 9976 3107 100507436 3106 80329 79465 3903 3904 79865 3134 27036 3133 146722 10288 6614 196500 3135 3683 933 3676 930 975 915 916 917 81035 3385 3384 3383 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling 84335 6194 10325 29904 1975 55004 8649 1978 1977 64121 1981 58528 64223 10542 389541 28956 57521 2475 10670 6009 153129 2280 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.3 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 8331 8337 8334 8335 10001 1050 8341 8342 8347 8348 8345 8340 79611 51129 8338 29079 85236 8349 4023 8370 9612 5925 9862 84649 90390 7403 3013 2167 948 11343 255626 3991 23175 3021 3018 2033 3017 5346 3014 6907 474382 8648 8970 10891 128312 22976 51003 10499 84962 55766 79718 8968 79447 133522 84246 8841 9611 23411 653604 1387 84661 9443 23054 11091 8085 5469 9442 5929 9440 8202 9439 2494 1020 9477 6256 10555 57104 8800 2874 729359 60481 1024 7069 63924 9282 2180 9968 9969 9370 22822 57678 94239 9070 6319 5166 25 54145 10025 123 58508 892 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling 5708 5709 10642 5700 2118 5701 5702 5704 5062 5705 2308 989 5682 5683 192670 5566 27161 5684 5596 5597 5685 5686 5717 5718 5719 983 26523 8997 11047 5713 2309 5714 3725 7979 5690 5691 5692 5693 5694 7311 8550 5695 5879 7314 23112 5687 5688 57690 5689 192669 896 5896 5897 998 4343 10602 5567 5568 4609 10435 3315 27327 7514 148170 5058 8556 9861 6233 3337 7316 10213 5706 8202 5063 5707 8555 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME%R-HSA-5619052.4 Defective SLC9A9 causes autism 16 (AUTS16) 285195 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 96%5358346 Hedgehog ligand biogenesis 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 10956 7311 5695 5034 7314 5687 5688 5689 85455 55733 57758 2262 27248 147111 6469 51009 6400 50846 84447 6868 7415 3549 9861 6233 7316 10213 5706 5707 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 96%5625970 RHO GTPases activate KTN1 5879 3895 3831 387 998 89953 391 64837 3798 147700 3799 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 96%5637810 Constitutive Signaling by EGFRvIII 867 1956 4893 6654 3265 5295 3320 5290 5335 2549 6464 1950 11140 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias 1836 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) 11136 6519 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 96%2980766 Nuclear Envelope Breakdown 23636 9972 5903 9631 7175 11097 23511 8086 8021 4001 64900 53371 8480 10762 8815 23175 891 348995 7443 983 221496 79902 57122 5347 2010 5578 55746 9133 23279 79023 255919 6396 140609 10783 91754 23592 23399 9663 9883 129401 9688 23225 5579 4927 23165 55706 DEFECTIVE LFNG CAUSES SCDO3%REACTOME%R-HSA-5083630.4 Defective LFNG causes SCDO3 4851 4853 4854 4855 3955 GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones 3626 3625 3624 3623 94115 7252 3972 83729 2488 1081 PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer 118788 5155 5159 50852 4916 4233 2475 5879 5156 5728 6714 2932 79109 5781 5880 1027 1026 146850 2323 2322 10818 55615 3815 3932 64223 2931 10000 23533 207 208 7409 6801 8503 2534 1147 2064 1956 2308 7039 2309 3164 2100 4193 7249 2099 685 255324 2069 1839 84335 930 3084 4915 4908 4909 9542 10718 627 145957 2549 374 4303 1950 572 842 3082 253260 9965 2254 2252 2251 27006 5294 5295 8074 5296 2249 2248 2247 5290 2246 5170 152831 8823 5291 8660 5293 2264 940 2255 941 942 9846 6199 3667 8817 391 26281 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 96%1442490 Collagen degradation 91522 1297 4317 4312 4319 4324 4327 1305 1303 85007 1308 4318 1307 84570 1306 8754 4322 5045 1991 102 1508 6868 4316 1514 1513 80781 9313 1299 1310 1509 5645 1298 4313 4323 7373 4320 4321 4314 136227 164656 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%R-HSA-201722.7 Formation of the beta-catenin:TCF transactivating complex 8331 8607 7090 8337 8334 8335 8313 8341 8342 8347 8348 8345 8340 79577 8338 7089 85236 1499 8349 7091 123169 8370 8290 6597 3013 7088 3065 255626 3021 3018 2033 3017 3014 4609 474382 8970 128312 8295 83439 94239 864 55766 9070 607 8968 7015 90780 283149 4221 51176 26108 653604 1387 84661 11091 54145 5929 6932 10524 6934 9757 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-HSA-9006936.9 Signaling by TGFB family members 650 4086 4087 4088 4089 7321 192670 27161 64750 4091 4092 3688 26523 10273 7040 23112 7027 867 57690 192669 5663 5664 8239 55851 83464 23385 51107 9612 5594 7029 5595 7049 7042 83855 10755 4323 92 4325 4343 7077 7076 10272 22938 3070 3065 3624 3623 142 5499 4904 1875 1874 7043 4052 4053 4054 25805 23645 5500 2033 3696 56937 3625 9958 8425 3694 9110 51377 8516 3685 27327 7514 5054 57154 4221 9611 25937 6233 7316 2280 5501 54778 23439 6925 3690 4617 4618 4654 4656 408 409 51592 1025 6929 8812 7311 7314 7050 5045 7046 7048 904 905 6938 91851 9765 27302 4090 9241 3693 4093 657 6256 658 659 94 4738 11167 64388 2658 268 269 5494 1030 60436 5914 3726 9040 1024 11171 1278 6667 4609 7323 4613 8928 23327 10468 50848 10589 5590 387 23370 57530 56288 130399 50855 91 93 2247 9350 6498 6497 5933 892 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR 1956 7039 14 8874 9146 6456 8027 6455 2060 7311 30011 7314 6457 867 10254 6714 4893 6654 81610 3265 5781 10252 5796 26018 84985 55824 685 6464 998 255324 2069 1839 5782 5335 2549 374 10253 1950 29924 5829 102 6868 222584 58513 5774 5295 5290 6233 8038 7316 1445 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 96%1295596 Spry regulation of FGF signaling 7314 867 5515 5781 5516 673 5518 5594 6233 5595 7316 10253 8569 7311 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication 5557 5519 5558 7027 28227 84515 5515 5000 5001 5516 23594 5518 23595 4998 891 4999 983 7029 1869 5925 23649 5422 RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME 3704 4830 64078 4860 4831 132 9153 100 22978 55315 2030 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs 1571 1558 1559 1544 1565 1576 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME%R-HSA-9958825.1 Activation of STAT3 by cadherin engagement 5708 5709 127544 5700 5701 5702 5704 7297 5705 3570 4790 5682 5683 5684 5685 5686 5717 329 50649 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 79872 7311 1500 5970 1499 331 1793 5695 5879 7314 999 5687 5688 6714 5689 1514 3572 9844 998 3569 57531 9855 6774 7074 3716 84231 1520 7410 1508 9861 3728 6233 7316 1495 3717 10213 5706 7414 5707 1009 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 96%5663213 RHO GTPases Activate WASPs and WAVEs 695 10552 10787 10093 71 8936 10092 51517 10095 10152 10094 10097 10096 3071 60 10810 10163 7454 7456 5747 10006 147179 5879 23191 4690 644150 26999 25 5594 10458 5595 10109 998 8976 55845 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine 10249 123876 341392 219970 92292 54988 389396 348158 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943962 CHD6, CHD7, CHD8, CHD9 subfamily 8331 3013 8337 8334 8335 255626 8313 8341 3021 3018 8342 2033 3017 8347 3014 8348 27123 8345 3481 8340 80205 474382 8970 128312 8338 85236 7975 1499 8349 94239 55766 8968 57680 10664 1728 4780 653604 84181 1387 85409 8370 11091 79843 55636 54145 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 5888 80010 5889 7486 472 672 675 83990 7516 5932 9156 7979 641 79728 116028 10635 10111 4361 7156 5890 5892 4683 580 10524 1763 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion 2864 948 9630 2769 5330 5331 23236 2182 2181 2767 2776 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 96%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling 51284 7334 7335 3665 7189 3654 54106 51135 4615 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) 8331 7004 8337 7003 8334 7005 8335 2353 192670 27161 8341 8463 8342 8347 8348 8345 26523 8340 53632 2475 51129 8338 85236 8349 4023 23112 57690 2932 192669 79109 81608 5781 8370 2146 4343 3013 55615 255626 5562 5563 6772 5564 5565 3021 3018 3017 3014 5571 64223 3054 474382 10000 8970 128312 27327 22976 83439 55766 8726 8968 7532 8467 9031 51176 7525 207 208 653604 84661 11091 25937 23512 5928 5929 8178 129685 6872 22916 6874 6873 6908 4686 6827 6749 6881 79685 6880 6883 8819 6882 6884 8148 9150 6917 1025 51497 11198 6875 6878 51742 83860 6877 8812 10284 2959 64426 2958 6879 2957 25920 54457 2961 8189 2960 11051 51224 6921 10978 1479 6924 7936 51692 1478 6923 1477 7469 23283 138474 30827 904 10914 53981 905 51585 29894 55339 60 10179 55596 23272 51535 7157 11168 23168 79577 80349 7040 10898 123169 9646 54623 57504 9112 142 8110 8193 26039 5977 6760 3320 9274 9275 605 8106 5901 6996 1998 1997 640 861 5079 865 81931 91661 125893 147658 201164 10555 25925 6657 23405 8575 9370 7257 6895 7247 7222 221400 122402 55124 84944 54456 143689 11022 91646 54514 4603 113802 8468 9271 56165 136991 123 5588 7534 200424 29128 7533 84649 7403 5443 2167 3065 11343 3815 3991 23175 6662 5346 1081 857 29947 147646 90853 79869 5045 6794 7248 55004 8649 64121 7249 58528 10542 389541 28956 57521 10670 6009 5494 153129 10325 4781 4782 6741 4784 4774 6667 4800 4801 4802 57678 6319 5166 355 834 1050 83737 54205 8795 8473 10273 8797 8626 581 64216 7019 84962 10514 79447 815 816 817 818 5566 8535 79813 7295 648 4194 8550 6015 890 4193 1912 1911 10919 5608 80012 84733 27287 6045 1030 1029 23378 3569 23466 8900 1051 57332 627 2904 28514 182 10419 6628 51808 6634 6636 6635 6637 1789 1788 1786 25946 57060 11200 51230 814 2903 10769 51593 25904 168374 5816 29028 284459 3630 90317 155061 10650 2308 121274 55571 54487 284443 6910 155054 90589 147694 1482 80778 339488 6929 246175 147686 147687 90338 3654 100129842 4986 4988 64065 22869 90576 90333 6940 2100 285349 353355 81856 81857 1490 23451 6938 100131980 79788 283337 4512 4513 4514 22835 3683 1263 2593 114787 80317 80312 146540 22823 84914 2145 84924 340602 57547 5252 2104 26147 57541 3720 2103 10526 2101 7978 55367 54790 3674 100170841 835 3676 3678 284252 839 90594 6871 6720 55683 90592 55689 84911 57104 146542 8800 10628 284058 729359 80314 1024 60481 843 55617 604 7069 847 63924 4778 91272 440077 54934 84701 10474 3458 2180 1278 1810 1277 51562 6722 26993 5875 26009 4303 29915 259282 5876 4322 112869 57325 56242 57573 84148 147657 51105 22822 57336 440073 80335 10848 864 57335 50943 6750 3486 3484 23327 199704 632 389114 51123 7832 10013 637 84289 639 10014 11105 162655 146198 117608 405 4336 283 6515 60528 10025 23309 7862 7621 2177 2176 892 650 51385 171392 7633 7874 148156 3276 23314 665 4298 341947 6830 79943 27125 7626 55840 4300 10001 7625 85403 11335 55677 7627 3280 6790 126375 25942 374900 55762 79973 79733 5457 5458 7638 348327 7652 23774 29079 57711 5467 55778 10224 8738 91875 7422 163732 221785 374928 3066 200845 148103 3064 694 79755 55786 79759 140612 4149 158399 10432 7673 9612 169270 463 79744 9862 6595 6597 619279 6599 6598 30818 728957 948 94241 84449 117584 84441 7678 117581 8784 7692 7695 7694 55729 5275 7697 121536 7699 163227 163223 79088 84676 28984 6839 84436 84671 8794 54807 9869 8793 8312 163255 23269 59269 54811 55900 54815 5054 9656 9891 8317 11059 80095 9422 10172 9668 201514 84246 51564 94039 23019 115196 50484 23493 51333 9443 7022 7021 9861 9441 9442 8454 126070 6233 7025 7316 26974 5579 65988 10213 25888 9440 23468 5706 7020 728927 5707 23460 5708 51586 5709 23462 10398 9439 5700 10397 5701 10155 5702 286075 5704 1956 5705 4790 7039 5682 126068 5683 374879 127396 5684 2811 2810 5685 51592 55713 5686 10168 9464 5717 114907 5718 84838 5719 2821 11047 26152 26155 5713 163081 5714 9219 7979 5690 374655 5691 9477 5692 7296 5693 7057 5694 112950 57472 7311 7291 5970 5695 57474 91120 7314 6500 7050 169841 5687 83744 5688 163071 83746 5689 83741 390927 147837 1749 8396 7067 7341 7068 1514 5241 204851 1513 7376 84626 6256 7421 80264 5465 1750 29883 3930 2099 1515 54737 7181 26149 6095 63934 367 57492 4929 163087 2908 79027 144348 9021 9759 5468 2625 3958 7329 2624 6613 60436 2623 2516 84883 5914 2626 90075 7486 3726 79047 2877 5982 84874 5983 2874 3364 472 84870 80032 672 113835 93134 199692 84126 144715 163059 83990 23067 5810 9282 2891 28996 5932 92285 92283 9156 256051 5111 11073 5915 5916 641 2645 146713 143686 6117 51741 341359 5984 3977 5985 2648 6119 63970 349075 2660 6118 163049 1327 163051 4839 5883 163050 5884 654254 116028 900 901 51082 84265 51755 55703 340252 1329 1111 112495 30832 11128 51728 65243 83695 285676 9533 4850 10111 9330 27297 1340 661 79891 4361 3516 2976 10623 4848 7156 2669 2975 5892 1337 2972 4849 4683 2971 171568 79898 580 5933 55814 4602 9328 5934 10524 9329 55718 1763 1339 10622 4605 545 10621 23619 1351 5888 65018 80010 1350 100287226 51529 1349 1107 7321 79885 8881 64682 1347 25906 1346 11065 388536 1345 8697 55215 7324 10393 10308 124411 29945 10781 27338 119504 10780 29882 4852 891 4853 246184 4854 10782 983 4855 996 65251 51434 1108 51433 162966 162967 162963 1121 4233 100289635 22974 388569 83933 388566 1499 388567 4869 388561 9099 5728 284309 6714 125965 284307 284306 400720 58500 10520 4878 10765 3562 55240 3559 1432 27165 3558 1378 147741 27166 253639 5594 7913 5595 10971 5978 5979 284370 115509 90233 5600 29117 57677 3329 22938 79230 7529 339327 339559 146434 26053 124446 353274 6601 6603 6602 6621 55290 6605 158431 6619 57209 7702 5770 6618 10302 91584 2033 7710 6617 57693 387032 613227 27153 6907 27154 57459 133383 7700 7703 8648 4435 10891 219749 10370 5300 7514 220992 10499 51003 10498 5775 79718 7712 6604 442319 7711 4208 79818 10135 10138 266743 4221 148254 4697 8841 9611 51499 5305 23411 5308 9572 90827 1387 7728 2290 23054 23429 1386 7743 5469 148266 148268 406 80818 2289 342926 23660 4773 56950 5451 55869 6886 8202 7733 54778 808 7738 9915 23439 730087 7752 7994 5052 2494 7753 7001 2064 2063 441234 7531 54541 8851 1020 55634 51276 353088 10018 7745 56729 5325 7988 356 995 7748 136051 10127 8850 7761 6648 7760 2309 91975 3725 7762 114026 3164 339500 4004 4488 100129543 7755 4851 4005 317 9978 7757 55888 7770 8861 219578 7771 7773 8621 90874 162972 23410 161882 148213 3174 3172 148203 51058 196528 148206 7767 5105 55659 7766 7769 55657 7768 7528 6696 5366 730291 126231 55663 1392 579 55422 84967 7884 6446 134353 6688 10794 10793 10795 7539 5371 7552 7551 9975 285267 9734 285268 4287 7556 255403 79862 348 9968 9969 7549 57615 90649 100131827 7561 7562 7565 7323 122809 7567 7566 7559 9739 8409 6241 94115 7571 7574 9997 7576 29959 51412 7568 80196 54925 8431 3549 7582 7101 25 7587 6498 7586 6497 6258 6257 7581 84108 9757 8427 7594 4086 7596 4087 4088 4089 22880 9534 8445 7592 126382 84333 199777 53615 9540 7122 2572 64750 2571 4091 23368 4092 4094 10445 85456 197320 84124 54715 5196 79611 9794 9310 6046 9314 64769 25799 1820 440519 440515 54971 9337 162239 7027 7159 1021 181 1019 90809 595 54989 1017 152687 5442 894 55835 896 10046 8239 898 86 8013 51343 79370 6502 8493 7161 1616 170960 9134 57343 1027 57103 1026 125919 147948 7029 147949 9358 1869 5925 170959 26048 55170 90390 80108 80110 221044 9125 6097 342132 285971 7182 6096 144455 1876 4904 1875 1874 26013 282890 344787 9377 8289 92595 55193 1643 27113 80139 168417 1649 2737 1647 2736 221830 79175 29115 133746 7343 93474 25885 2744 79595 84527 9014 387893 9015 84765 9013 58484 64425 57154 7270 83667 79101 3845 10849 133522 11176 9167 30834 121340 84172 58491 58492 1437 1436 147923 27300 59348 147929 340385 8089 112858 8085 84775 3622 2539 2538 5519 332 5515 5516 5518 9212 2074 54700 5527 5395 144233 4436 57510 9188 29102 4292 65123 57508 80789 26173 55726 5452 55756 64859 26512 23248 25896 100506658 80237 79035 79664 29101 7082 22936 81556 55656 5440 79871 5441 23379 8732 54973 4331 92105 8731 55174 1022 57117 2071 55197 6829 84524 2966 58490 2965 2963 2962 2068 5434 5435 8932 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 4297 1460 1459 1457 4609 5931 10413 94239 9070 253260 51422 1493 5170 23517 54145 6932 6934 284119 58508 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 7157 1026 25946 57060 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease 11116 22916 4686 9208 613 4893 6654 3265 5440 5441 10818 7750 2963 2962 5434 5435 5436 5437 5438 8805 5439 6772 5430 5431 6774 5432 5433 2263 5335 2260 2549 2261 11160 399687 11052 26127 2254 1523 2252 2251 27006 8074 5295 2249 6777 2248 6776 2247 2246 5290 8823 2264 2255 9846 8817 26281 9530 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 96%9769726 Defects of Coagulation cascade 5624 7450 2157 2147 2243 2811 8460 2153 2160 2677 2159 2158 196527 8459 2812 5627 2244 2815 2266 2814 PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy 8878 7314 6233 84749 7316 4077 5830 472 2034 7311 81631 SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 96%9842640 Signaling by LTK in cancer 5296 5290 5291 5594 5595 6249 5295 NETRIN MEDIATED REPULSION SIGNALS%REACTOME%R-HSA-418886.3 Netrin mediated repulsion signals 137970 8633 1630 6714 9423 219699 5781 90249 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade 7321 2353 841 8737 329 11035 7186 8767 4791 330 7322 84166 4205 10454 7334 6285 7335 929 6288 7187 11274 9641 7189 64127 353376 6283 148022 3146 257397 5781 10010 9261 10133 23118 9683 9684 6195 1432 10392 28512 79155 79671 5594 177 5595 121457 28511 3656 9097 466 5600 51231 1849 7867 1848 1846 1845 5604 23643 4208 7099 1386 8454 6233 7316 1326 6885 23291 80216 92610 1147 5519 3665 4790 351 4792 5515 6197 6196 4793 5516 5518 8945 3725 3654 5528 7311 5970 7314 6500 3551 8517 5608 5609 6416 5601 5602 5606 5598 2002 5599 29110 3661 7323 7157 9252 8772 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC 7411 10381 10383 10382 7846 60 84790 10471 5201 5202 84617 347733 7277 22948 7278 81027 908 113457 6950 7203 7280 5203 5204 10693 10574 10694 10576 10575 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 96%1428517 Aerobic respiration and respiratory electron transport 1351 1350 79751 1349 83733 8402 8604 1347 10165 1346 4190 4722 4191 2109 1345 3954 4698 125965 613227 4697 148811 4512 23410 4513 5091 4514 28976 4728 4729 4720 10048 4723 4725 4726 25915 55572 4731 152100 93058 100996939 3420 116228 28958 55101 51300 1353 84701 374291 3419 3418 6389 55471 80775 54949 4706 2110 119559 6391 6390 6392 4540 2108 4541 122961 4535 51204 4536 285521 4537 6834 4538 84233 80219 25880 80224 51103 389203 284184 9997 4694 4695 4696 5162 2271 5163 79133 5164 57226 5165 51241 5166 126328 64795 8802 10131 23409 4750 8803 64777 291 55967 8801 8050 160287 55969 81889 81689 57001 92483 5160 644096 5161 1355 84987 57546 100303755 55066 55744 3939 55863 79018 54539 51660 91942 54994 90871 10296 23530 10873 3052 1737 29078 347411 100131801 4200 137682 192286 4289 25874 341947 751071 2806 25852 4705 2805 3948 4707 80232 4708 2875 4709 2739 135154 3945 4700 54704 4701 4702 4704 6341 79064 54205 4716 493753 4717 4718 4719 51079 38 4710 4711 4712 4713 4715 51295 27109 4508 4509 498 7352 7351 3313 9016 513 9481 514 515 516 517 539 7350 518 10476 10632 9551 9556 84833 521 522 9377 506 509 4199 9167 6233 7316 1743 4967 728294 79944 137872 2954 5018 7416 7311 7314 92259 7385 7384 7386 440957 7388 440567 2395 7381 3421 728568 55245 10975 29090 57128 4519 27089 29796 90624 84300 617 150274 54902 790955 50 1537 90639 10063 1431 25994 1327 1738 4714 1329 1340 1337 1339 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 29780 55742 87 3987 6251 5829 9459 7016 TYROSINE CATABOLISM%REACTOME%R-HSA-8963684.5 Tyrosine catabolism 3081 6898 3242 2954 2184 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling 2064 1956 4893 6654 3084 3265 9542 10718 145957 685 1950 2069 1839 IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) 7100 81793 51135 4615 GSD XV%REACTOME%R-HSA-3814836.4 GSD XV 2997 2992 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%R-HSA-1799339.4 SRP-dependent cotranslational protein targeting to membrane 6230 6231 6234 9349 6235 6191 6193 6192 6194 55176 6185 51121 6746 6748 6227 6747 6184 6229 6731 6228 29927 6730 11224 6729 200916 23480 6726 6122 6728 6124 10952 6727 6123 23471 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 90701 6164 6166 6165 6168 6201 6167 6203 6169 1650 6202 116832 6160 6161 28972 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 23478 6208 6188 6187 6223 6189 6222 6224 6181 6218 6217 58477 6745 7311 6734 9789 60559 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME DATABASE ID RELEASE 96%198725 Nuclear Events (kinase and transcription factor activation) 5519 2353 7166 8851 6236 1020 2152 5515 6197 4066 6196 8941 5516 5518 3398 429 3399 8061 10221 4664 1108 4665 23237 1961 2354 1960 7425 5528 6457 4205 6938 9261 6195 1432 5594 5595 5978 5598 2002 466 51231 5600 1849 1959 1848 1846 1845 6446 3726 2033 3397 3400 1785 6722 4208 1958 4209 3727 9252 1386 RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 96%5625900 RHO GTPases activate CIT 389 4628 5879 79784 10398 388 9055 4629 387 5500 1027 9928 1742 11113 4660 103910 4627 4659 4637 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 96%211897 Cytochrome P450 - arranged by substrate type 9915 66002 6916 1572 5740 1571 1582 64816 57491 196 1558 1557 1577 1555 1544 1565 1543 1576 1553 29785 1562 1573 1551 54905 1549 1548 1559 10858 1594 1584 6256 51302 5447 131 4051 120227 11283 126410 5443 1580 1592 57834 284541 56603 1588 340665 285440 112812 2232 2230 1589 1585 1583 8648 9971 9420 10499 1593 1581 1591 1595 1579 1545 113612 8529 405 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%5652084 Fructose metabolism 229 26007 231 6652 216 132158 3795 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production 5970 170506 3665 4790 1660 4791 4615 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.5 Cardiac conduction 8645 56660 60598 9424 3775 10089 10008 23704 9992 23630 3753 4878 30819 30820 80333 1066 30818 4311 10142 59284 476 477 478 6546 53822 4842 6547 3710 53826 5350 3751 10060 3752 53828 7137 80228 480 1193 56659 481 3757 2281 482 3770 483 338567 486 487 488 444 489 84876 25937 5348 5349 10345 3767 6717 490 3776 491 3777 492 51305 493 815 816 808 817 818 3784 6263 6262 6588 6786 6543 83795 6261 10768 3708 3709 1760 5566 54207 50801 6910 11280 1482 8850 3750 89822 3741 55800 6324 6323 204851 6331 6330 6332 6335 4880 6334 4881 4882 10699 6326 6328 6327 6329 6336 2626 3761 59285 775 3759 2259 29098 2258 2257 2256 28996 7220 3768 27092 9254 782 783 59283 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors 2865 2864 2853 338557 2867 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 96%9026527 Activated NTRK2 signals through PLCG1 4909 5335 627 4915 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%438064 Post NMDA receptor activation events 808 817 2890 818 107 84254 5923 5924 5566 6197 6196 28964 53632 5879 6714 4893 3265 6195 5594 5595 5567 5568 5562 5563 3084 5564 5565 2891 5571 3838 114 2904 5575 4900 51422 10645 5573 88 1740 2906 8536 2905 5170 5577 814 2903 4747 5613 2902 1742 27330 5576 1741 1739 815 816 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665737 Drug resistance in ERBB2 TMD JMD mutants 3320 55914 2064 11140 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-HSA-9034793.3 Activated NTRK3 signals through PLCG1 4908 4916 5335 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins 55048 89853 7314 155382 137492 93343 7251 51271 79720 9397 6233 7316 7311 51160 ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 96%187015 Activation of TRKA receptors 135 4803 116 117 4914 4915 NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9831926 Nephron development 3172 79192 54361 7484 7490 28514 182 3975 5455 3955 153572 6928 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 23385 51107 4854 4904 5663 5664 55851 83464 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK 55437 10325 5562 5563 5564 5565 5571 64223 53632 2475 51719 6794 7248 51422 55004 8649 64121 92335 7249 58528 10542 389541 28956 57521 10670 6009 5494 153129 81617 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%350054 Notch-HLH transcription pathway 22938 3065 84441 79885 9734 4853 4854 8850 4855 6907 9794 83933 2648 4851 79718 3066 51564 10046 8841 10013 9611 10014 1387 3516 9612 55869 9759 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation 10621 5434 6908 5435 5437 6621 55290 6619 7702 6618 4781 10302 4782 6617 6741 4784 4774 51082 84265 55703 112495 11128 51728 9533 9330 27297 661 2976 5440 10623 5441 2975 2972 2971 171568 55814 5451 9328 9329 55718 10622 TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules 79751 83733 8402 10613 56606 91445 6048 9388 26119 27329 338328 319 81693 91319 255738 51129 10577 10956 9619 1965 8894 91289 10062 5034 4023 1968 8029 19 6523 160 215 6248 161 1071 6514 116519 6531 163 2 23443 23491 29116 23428 92745 57552 6511 4018 6533 8435 6510 213 27248 206358 336 5002 337 84889 4864 120103 6509 6646 3931 55089 4547 117247 79139 26291 340024 10991 55908 6506 3990 6505 64788 1175 54716 1173 6507 51009 341 9056 3949 9057 6400 8501 344 6583 345 153201 6520 6563 346 6541 3069 8170 55244 123096 84699 81539 115286 51599 5824 5567 146802 8140 23657 85413 55911 55117 55356 84061 5568 56301 3988 11254 6512 6539 11136 6519 124935 54407 111 29801 112 113 7991 114 115 120 5575 115584 114134 6526 7415 23169 5577 11046 196883 107 108 109 118 284129 10861 114757 1836 347734 26503 26234 26154 9197 368 116085 8671 6530 123041 10999 6524 51000 10599 7355 5172 55630 1811 6513 10058 6566 9152 682 6575 5244 28234 81031 55315 402 283652 6578 57468 6560 10723 6557 6559 6558 9990 23327 57084 6534 9497 6536 291 292 6515 293 1468 1213 9187 1211 154091 155184 65010 81614 144195 80772 4645 159963 22841 4363 27173 84912 7922 66035 28231 55144 83850 1185 284111 376497 283375 23568 79815 6508 286256 6522 2039 6581 55974 5243 5304 353189 152519 64241 54896 64240 55867 89872 6527 65125 125206 64116 63982 1187 11309 23200 6561 222962 203859 1186 563 1184 115111 1183 55532 1182 6556 1181 57835 7781 133308 1180 4151 79895 7780 23507 11059 57101 1179 6574 6576 479 25800 150159 6568 51761 6567 7439 7779 51802 254428 22802 219931 91749 286410 5573 23516 4284 9635 338440 11182 57185 57198 57181 57194 1188 85414 10786 58157 285175 359 65266 9861 119 65268 93380 8454 65267 8714 6233 360 285335 7316 361 64849 495 362 496 10213 363 144453 10110 115019 5706 9914 23382 10079 84102 5707 538 343 28965 5708 55107 84230 23460 5709 94015 51228 348938 57130 23678 282679 5700 540 9356 5701 28962 56262 5702 5205 123606 5704 55515 200010 5705 40 389812 41 57488 861 5682 266675 3933 5683 23400 9498 374868 26266 5684 54831 80131 90550 23120 29986 55129 5685 8165 57380 91689 375318 50636 5686 6687 9311 56172 5717 8884 9512 161003 29985 5718 10939 259232 9154 5719 23203 84239 53919 55486 7809 57282 55013 11047 23250 83697 5713 80024 284525 1317 5714 79568 196527 9058 7979 57719 221154 1201 57205 5690 11331 5691 7417 1831 344905 5692 30968 5693 7416 10396 10730 5694 6340 51248 10367 7311 80727 7419 148229 27032 5695 51296 286097 57578 6564 7314 1497 6500 121601 121260 51076 5687 53373 5688 6337 6339 5689 6338 7376 8766 7220 7442 7222 7224 7223 7226 6517 7225 59341 79054 55283 23539 26133 54795 9123 9194 8989 55503 133418 4308 57419 162514 255231 25769 57192 51393 80036 56302 57113 29850 54822 140803 1080 3954 11194 23344 23456 23457 10349 89845 85320 5825 10347 20 23 24 340273 10350 64137 23461 10351 8504 225 55240 113235 3043 3162 3040 335 51706 760 338 762 21 358 6005 6521 606495 51167 51700 759 6528 64078 3177 9153 2030 347 10057 5576 10257 808 126969 204962 345274 80736 57153 60482 23446 55343 5045 5046 5125 10559 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 94235 55970 6446 375 10568 6569 142680 51360 54331 348 59345 51128 140679 6532 6529 6540 9376 6579 8720 2782 6538 57030 2778 6582 6580 10681 1244 6584 7436 246213 64924 169026 476 477 478 6546 53822 6547 57127 53826 51458 5350 10060 53828 480 1193 481 2281 482 483 486 487 488 444 489 5348 5349 10345 3767 84725 160728 6717 5245 490 491 492 493 815 816 817 818 6263 6262 6588 5894 6543 6261 5566 22 551 48 4891 245972 245973 554 30061 3163 10539 155066 9114 51606 9550 94033 4738 2512 79689 523 9429 525 526 527 528 529 8992 9843 90423 2495 127124 23545 51382 1356 533 534 535 7018 537 10312 364 3658 366 3934 50617 7037 7036 3077 9296 55832 51310 79901 84679 6550 6553 389015 6548 6549 10479 285195 23315 11160 29988 2040 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 96%194315 Signaling by Rho GTPases 55971 8331 70 2017 10395 23092 143872 8337 10276 5099 347902 8334 9138 4810 55619 388 10787 8335 128239 85360 1729 8936 11214 5062 5881 128272 10152 26230 2185 29 121512 84904 64411 286205 124056 29127 8341 25791 613 89846 8342 51347 26050 8347 22899 3071 8348 8345 10163 50649 5364 28964 22865 8874 64857 653361 8340 23075 57449 116984 27035 23081 55114 354 2245 3817 4952 10006 221472 8338 55701 10672 9459 85236 389 8349 58480 5879 708 4771 54763 30851 9055 55200 399693 253959 23616 115703 139818 201176 57514 57636 6510 55219 55227 8370 26092 124997 58504 1072 1124 1123 10409 91452 114793 57679 998 114885 57569 27145 92799 57572 3013 10602 752 55968 51133 55852 255626 10144 64333 10093 116985 10092 25963 10095 79834 9912 10094 101059918 79822 10097 3021 23526 10096 3018 54438 1855 3017 157285 3014 29062 9938 10810 23779 3932 51291 9824 56990 474382 10435 83478 1857 84681 1856 7454 120 8970 7456 84317 128312 9644 23268 51306 147179 9411 94134 55766 393 399 11180 51566 8968 5361 84364 94240 171177 1362 7532 148170 22852 23348 89839 2886 27289 23580 222584 84144 55704 2802 65992 22800 8502 7409 10160 653604 11075 25894 91544 7415 55831 644150 51479 9231 57579 8503 54509 57216 26999 55717 224 10928 667 1730 9528 93663 9928 26049 1495 10963 9590 57473 123720 10109 80115 8976 158747 1445 4627 57120 8153 57480 117289 695 84986 10552 23129 343578 50619 157769 221178 257106 153478 114822 29984 51517 11060 445582 152273 79180 80243 23074 23197 10134 2697 908 10574 10376 10576 60 6722 23048 91010 57381 54874 2631 144402 8476 81704 9497 9578 23513 23229 64130 4628 79784 8086 3984 3985 5924 85440 57591 1213 23380 57522 9901 80728 29843 5783 3320 79658 5578 9738 5579 10398 2810 10250 7919 3930 367 5338 84612 9855 79598 5590 387 23370 50855 54514 1080 200894 6472 7444 7204 9743 4660 2909 391 94274 4659 57584 392 9341 394 57580 396 26030 397 398 80005 7879 5337 4722 10298 10652 3954 3998 9710 81839 10788 26084 26286 4698 3688 8997 6453 7984 5347 2010 9146 23344 143098 8027 63916 3336 23141 23263 5825 1794 1499 1793 4983 3895 999 8987 55789 10254 4162 6714 7112 9217 4168 6654 9732 27237 23191 81624 23592 2889 11135 6811 55240 5880 1969 1432 55914 6279 6280 5594 5595 7534 10971 7533 10818 57498 5600 7529 55075 5500 2316 5747 5300 7514 27 10499 8440 857 4650 7410 4221 51466 56924 4690 10451 10424 23028 6655 11140 6434 9886 8654 57144 808 23221 5216 29766 5217 6093 3183 55023 11329 56254 5930 4001 71 7531 9318 5756 4646 7431 9475 124540 23013 27316 9352 3326 995 2873 79869 51138 1627 87 6709 4629 6711 55004 7170 7171 103910 4637 4638 56667 4548 5289 25 30849 1742 8452 9462 10211 2319 57630 8239 832 1027 54908 6232 8655 25909 3798 3799 8379 9183 1063 1062 9184 4580 1060 991 151648 25813 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 348995 348235 5580 5048 23421 57122 220134 57082 57405 147841 51143 6249 55746 4085 64105 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 1781 23122 1780 79172 8776 1778 81930 55920 84643 3796 4296 9793 91687 7535 57551 79682 5905 64837 1783 5501 147700 83540 80152 5903 2491 8826 5519 332 55143 699 3831 11243 140735 3619 5515 89953 11004 5516 5518 9212 25936 11130 64946 79980 10726 79902 5525 5526 55839 5527 5528 5529 23256 3163 1832 9414 1829 1828 537 7037 7074 1795 10817 8301 94239 50618 6793 182 65124 5585 5586 55160 1629 23002 23365 115557 7126 9181 390 29941 11188 10970 85415 5295 1152 5296 1894 4649 10505 5058 253980 8773 6242 9754 5290 50508 2040 5170 395 1536 3728 54443 9322 10811 54145 9748 1535 10458 9826 55843 11113 10979 90627 64283 9815 4688 9828 284119 55845 4689 50650 9639 5063 9235 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9034013 NTF3 activates NTRK3 signaling 4908 4916 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis 7376 10062 6256 6319 2194 27329 8204 6257 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 239 ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway 9341 5708 5709 695 1147 5700 5701 3105 567 5702 5704 2243 5705 7097 5682 7096 5683 5684 5685 5686 5698 5717 5699 5718 5719 11047 5713 9554 5714 7979 5690 5691 5692 5693 3107 4615 5694 3106 7311 5696 5695 7314 5720 55176 5721 3134 3551 3133 6890 5687 6892 5688 6891 8517 929 29927 5689 6810 23480 10952 3146 3135 6279 6280 10333 811 114609 948 6271 8673 23643 2923 7099 8773 9861 6233 7316 10213 2244 2266 5706 5707 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 96%9034015 Signaling by NTRK3 (TRKC) 6714 5802 4893 6654 581 3265 5295 4908 5290 4916 5335 5800 25920 3667 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432040 Vasopressin regulates renal water homeostasis via Aquaporins 55970 107 5567 108 109 5568 5566 111 54331 112 113 114 59345 8766 115 358 551 2793 2792 2791 5575 2790 554 5573 2788 2787 2782 2786 359 2785 5577 2778 2784 360 361 5576 2783 10681 4645 51764 196883 94235 22841 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants 2322 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes 468 1649 4800 3309 4801 7184 811 4802 22926 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints 80010 84515 51512 5000 8341 5001 23594 8342 23595 4998 8347 891 4999 8348 8345 983 8340 9088 85236 8349 7336 7334 11200 1017 10926 7465 55388 8370 7534 10971 7533 7529 255626 7468 29086 9025 51720 63967 84142 165918 7158 3018 3017 3014 9577 79184 8970 128312 9133 9656 8317 7532 9861 6233 7316 10213 5706 5707 5708 5709 5700 5701 5702 5704 8924 5705 7531 5682 5683 5684 2810 993 5685 5686 995 5717 5718 5719 11047 5713 4172 5714 4173 7979 4174 5690 4175 5691 4176 5692 5693 5694 8318 7311 4171 5695 7314 890 5687 5688 5689 8290 51588 7486 5982 5983 3364 8900 472 672 84126 144715 83990 5810 5932 990 9156 11073 641 6117 5984 5985 6119 6118 7157 5883 5884 116028 1111 83695 10111 4361 7156 54145 4683 580 10524 1763 545 MITOPHAGY%REACTOME DATABASE ID RELEASE 96%5205647 Mitophagy 8878 65018 54543 9804 7332 5071 81631 55669 9927 1460 10452 1459 29110 1457 7417 100188893 7416 7311 7323 401505 51001 7419 56993 7314 7322 7334 7335 8408 10133 9868 9140 9474 6233 7316 84557 139341 79065 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling 7321 2353 5062 7006 5879 7322 997 10454 7334 7335 4893 5588 7189 6654 10235 3265 257397 115727 4214 23118 5594 5595 3710 7410 7409 10451 9861 8454 5336 6233 7316 3937 10892 4772 4773 10213 2534 6885 5534 5706 3702 23291 7462 6850 5707 4775 5708 808 5709 695 1147 5530 84433 5532 5700 10125 5701 5702 5704 5705 10768 3708 4790 5682 3709 5683 4792 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 3725 5690 2206 5691 2205 5692 5693 5694 7311 5970 5695 7314 6500 3551 5687 5688 8517 5689 8915 5609 6416 5601 5602 7294 5599 5335 4067 9402 5295 5296 5058 5290 5170 5291 2207 9846 G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint 9133 7465 891 983 890 8900 9088 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade 2353 8651 841 7186 8767 4615 4791 57162 84166 4205 10454 7334 6285 7335 929 6288 11274 7189 64127 6283 3146 51295 257397 51135 9261 4214 23118 9683 9684 6195 1432 6279 10392 6280 28512 79155 57161 79671 5594 177 5595 121457 246330 28511 59307 3656 9097 466 5600 51231 114609 1849 7867 948 1848 11213 1846 6271 1845 5604 23643 4208 7099 1386 8454 6233 7316 1326 6885 2244 2266 23291 80216 92610 695 1147 5519 2243 4790 7097 7096 351 4792 5515 6197 6196 4793 5516 5518 8945 3725 3654 5528 7311 5970 7314 6500 3551 8517 5608 5609 6416 5601 5602 5606 10333 5598 2002 5599 7157 9252 STABILIZATION OF P53%REACTOME%R-HSA-69541.7 Stabilization of p53 1029 5708 5709 5700 5701 5702 5704 5705 5682 5683 472 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 4194 5695 7314 7157 5687 4193 5688 64326 5689 11200 51230 9861 6233 7316 10213 5706 5707 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 96%6806667 Metabolism of fat-soluble vitamins 344 26020 345 6382 154807 57016 79001 2719 151056 54884 51109 221914 9672 5950 9227 2239 5948 348 83875 338328 335 5406 7804 5947 338 1208 29967 3339 4023 1645 1109 2262 7276 336 337 53630 55937 2817 4036 7274 6383 29914 10082 6385 375790 4035 8644 3949 SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 96%1227986 Signaling by ERBB2 5782 8065 2064 1729 1956 3084 5581 3320 9542 5335 51072 5580 10718 145957 2549 9101 10000 1950 10273 5578 7311 7314 6714 4893 2886 6654 387 7525 3265 207 208 5295 55914 5290 10193 4145 6233 5753 26469 7316 6464 685 2534 11140 2069 1839 MRNA POLYADENYLATION%REACTOME DATABASE ID RELEASE 96%9770562 mRNA Polyadenylation 10898 81608 3192 5499 4904 57794 5500 22826 22827 10262 11325 10236 55749 8106 23524 9879 6233 10181 7316 5093 5094 6434 1660 51593 84844 1655 22916 3183 4686 8175 5930 27316 10992 79869 5725 10523 4670 9584 6631 10929 8189 7311 10772 11051 6625 6627 10978 6626 6629 1479 7314 135295 220988 51692 64852 1478 1477 10915 23283 6430 58517 23450 10914 6432 27336 23451 6431 53981 55660 51585 5511 29894 5514 55339 6638 51362 199746 6427 6426 5440 6429 5441 6428 3178 3181 3188 3187 3185 2963 3184 2962 5434 8683 5435 22803 5436 3191 5437 3190 9295 5438 5439 51639 11338 5430 5431 5432 64895 7307 5433 10291 8241 23350 10285 10946 6632 6628 1665 84991 6634 2521 6633 83443 6636 6635 6637 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) 2990 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME%R-HSA-9022538.2 Loss of MECP2 binding ability to 5mC-DNA 3065 25942 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9968551 Regulation of GBP-mediated host defense 5292 834 2633 2810 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis 293 7040 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding 5519 1452 139285 2932 5515 324 5516 5518 8312 5525 5526 5527 5528 5529 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation 808 1915 254013 2109 3312 7415 221143 151194 399818 79823 196483 10196 79609 6187 79091 1938 22944 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway 111 112 113 2774 114 107 115 108 109 196883 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 9061 9060 7296 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis 8443 8540 25979 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9022707 MECP2 regulates transcription factors 4208 54715 5468 PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling 5140 208 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844455 The NLRP1 inflammasome 596 598 22861 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 96%68949 Orc1 removal from chromatin 5708 5709 5700 5701 5702 5704 5705 5682 5683 84515 5000 5684 5001 5685 23594 23595 5686 4998 5717 4999 5718 5719 11047 5713 4172 5714 4173 7979 4174 5690 4175 5691 4176 5692 5693 5694 7311 4171 5695 9978 7314 6500 890 5687 5688 5689 1017 81620 6502 8900 990 9861 8454 6233 7316 10213 5706 5707 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance 983 5347 53632 1432 6300 5600 5563 5564 5565 96764 5571 6907 80205 3054 8648 10891 51106 10499 10498 79718 6604 4208 4209 7532 64784 8841 9611 9572 200186 1387 23373 23054 1386 814 5577 5469 85441 808 7531 6648 6950 23410 7203 10694 10576 10575 2101 7978 10383 10382 6608 7846 3418 7277 22948 10013 23409 211 57576 54205 6010 1258 56652 11232 55835 5442 440574 6742 27109 79135 4508 4509 55902 498 3313 84303 513 514 515 8655 10651 516 517 539 518 10476 10632 4580 9551 9556 25813 84833 10989 125988 521 522 10142 23332 139322 55735 8834 4899 506 54927 3320 22919 509 5048 6991 64792 7840 6753 92104 64216 9742 7019 11064 23322 22994 22995 7283 27241 203068 133522 55722 1453 54820 9738 80776 79659 11190 5310 5311 261734 1781 23059 22920 95681 55212 51098 1778 117177 1069 28981 403 51134 54801 9793 10540 51259 54806 4218 4735 79809 26160 11116 23265 92482 83657 150737 84902 84747 200132 83658 54930 378 140735 60412 84100 5566 79959 54536 51668 5518 4867 2847 93323 9657 91147 22981 9371 55112 27077 80254 55755 10806 26146 85302 10121 10640 57539 11336 129880 89891 9662 149371 347240 11020 1262 55081 1260 22832 57787 2551 57545 10733 84808 80321 23408 123016 2746 6256 23082 55764 55125 2747 5465 55763 9814 3797 79738 8729 8100 112752 26005 115106 166379 79441 55770 79600 26123 9702 79969 3842 5108 9321 50807 57560 55142 22897 8195 79598 5116 56912 80184 255758 11127 57728 51626 132320 6102 90410 8766 23354 146057 8481 582 583 54585 585 27031 121441 192668 79867 79989 9727 55559 1454 8636 4751 11258 84131 80173 54903 4957 51422 56623 5147 200894 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 5440 5441 8732 4331 8731 1022 2071 6829 2966 2965 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%446728 Cell junction organization 8331 8337 8334 8335 100128731 192670 27161 8341 8342 8347 8348 1308 8345 50649 3688 26523 8340 8338 51129 2060 9459 79872 85236 1500 1499 8349 1793 5879 6185 999 23112 6184 6714 57690 192669 746 1603 6591 26508 8370 9844 5594 5595 2146 998 4343 3013 3065 255626 2318 6251 6774 7016 3021 29780 3018 6663 54751 3017 7841 3014 55742 3611 474382 55679 90701 3987 2316 3703 8970 128312 27327 3716 55766 1650 8726 8968 23193 7410 28972 5589 23411 653604 2294 667 56978 8728 64403 23512 1495 27319 5928 23028 23478 80332 1006 3224 3609 6615 1009 7764 7408 7297 5339 6929 87 5045 5046 288 6938 11171 55810 687 93986 9789 1785 6667 29954 10585 60559 283 3691 3655 3570 7122 329 3170 9314 5584 331 54971 3066 9076 5925 6597 117581 57531 821 8289 387893 84231 1520 1508 9861 6233 7316 3717 10213 5706 7020 7414 5707 5708 5709 1013 5700 127544 5701 5702 5704 5705 4790 1002 5682 5683 5684 5685 9069 5686 81607 5717 5817 5718 27085 5719 5818 5819 11047 57863 5713 137075 5714 94234 7979 24146 5690 9073 5691 9071 5692 9074 5693 9075 5694 84552 7311 23705 5970 7291 283106 5695 9080 7314 53842 1010 1008 5687 4193 1007 5688 1005 1004 5689 1366 1003 1365 1364 1001 1016 1514 1015 1012 51208 3572 7490 49861 10399 54737 221935 348262 23562 253559 149461 26285 80149 5315 7750 10009 3569 84612 60436 54549 7088 25945 9159 28513 5010 9855 10686 7074 1460 1459 1457 9839 4609 5931 5829 1000 94239 6935 4613 50848 23396 10207 92359 64398 56288 50855 1488 1487 3728 54145 3914 58505 10979 977 3918 9743 3909 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism 6613 7421 2638 8029 1591 5641 4036 26119 51588 120227 1594 7329 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME%R-HSA-9636003.2 NEIL3-mediated resolution of ICLs 55247 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions 8935 961 10326 140885 7305 2185 2533 5747 5781 5777 55423 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME%R-HSA-8932505.1 DAG1 core M3 glycosylations 148789 29954 84197 84892 1605 10585 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay 25904 55571 5393 11340 22894 23016 23404 85456 5073 51010 54512 246175 51013 56915 118460 80349 57472 9337 1975 1977 1981 29883 1974 1973 9125 9652 9775 10767 115024 28960 23318 6499 79670 219988 23658 25804 27258 23644 54464 51690 10605 1656 9924 196513 255967 27257 167227 55802 11157 57819 80153 26986 23019 4850 4848 4849 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-HSA-420092.5 Glucagon-type ligand receptors 55970 2692 2691 54331 59345 2642 2641 7433 6344 2793 2792 2791 7432 2790 6343 9340 7434 2788 2787 2782 2786 2785 2778 116 2784 2740 2696 117 2695 2783 10681 51764 94235 DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 96%9734195 Defective APRT disrupts adenine salvage 353 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding 4913 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 96%4085023 Defective GFPT1 causes CMSTA1 2673 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 96%5603029 IkBA variant leads to EDA-ID 5970 1147 3551 8517 4790 4792 4791 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 96%9709570 Impaired BRCA2 binding to RAD51 5888 80010 7486 5982 5983 3364 472 672 675 84126 144715 83990 5810 5932 9156 11073 7979 641 6117 5984 5985 6119 6118 5883 5884 116028 83695 10111 4361 7156 4683 580 10524 1763 545 INHIBITION OF PKR%REACTOME%R-HSA-169131.8 Inhibition of PKR 5610 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764725 Negative Regulation of CDH1 Gene Transcription 8331 8337 8334 8335 8341 8342 8347 8348 8345 6929 8340 94234 8338 7291 85236 8349 3066 6938 6591 8370 7490 54737 5594 5595 348262 2146 6597 5315 7750 10009 60436 3013 7088 3065 255626 117581 3021 3018 3017 3014 9839 474382 5931 8970 128312 387893 94239 55766 6935 8726 8968 23411 653604 1488 1487 23512 54145 5928 23028 6615 7764 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163767.6 PP2A-mediated dephosphorylation of key metabolic factors 5519 51085 5515 5528 5207 5516 5518 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 96%9665246 Resistance of ERBB2 KD mutants to neratinib 3320 55914 2064 11140 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression 8331 8337 8334 6908 8335 1107 53615 8341 11335 8342 8347 8348 8345 8850 8340 1108 2074 9219 8338 85236 8349 9188 23451 2932 3066 10919 8370 5440 5441 7913 57504 9112 3013 3065 5434 5435 255626 5437 3021 3018 2033 3017 60 3014 474382 57459 5931 221830 8970 128312 25885 54815 9014 2648 9015 94239 9013 55766 64425 7270 10514 79101 8968 10849 8467 30834 9031 84172 51082 653604 9533 54145 5928 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9630221 Defective NTHL1 substrate processing 4913 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 96%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 1793 5879 9564 4893 387 3265 5921 1398 9844 5753 2909 63916 5829 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 96%417957 P2Y receptors 9934 5030 53829 10161 2840 5028 2846 27334 5029 64805 5031 5032 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis 231 6652 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%425407 SLC-mediated transmembrane transport 79751 83733 8402 56606 6523 6248 6514 6531 23443 23428 92745 6511 6533 6510 206358 84889 5002 120103 6509 55089 117247 26291 340024 10991 6506 6505 54716 6507 9056 9057 8501 153201 6583 6520 6563 6541 8170 55244 123096 115286 81539 146802 8140 85413 23657 55117 55356 56301 11254 6512 6539 11136 6519 124935 54407 6521 6528 64078 3177 9153 115584 114134 6526 2030 347 23169 11046 808 284129 10861 126969 204962 345274 80736 57153 60482 23446 55343 10559 1836 347734 26503 9197 116085 8671 6530 123041 10999 6524 51000 10599 7355 5172 55630 1811 6513 6566 9152 682 6575 28234 81031 55315 402 10568 283652 6569 6578 142680 57468 6560 10723 140679 6557 6559 6558 9990 6532 6529 6540 9376 6579 6538 57084 9497 6534 57030 6536 291 292 293 6515 6582 6580 1468 9187 6584 246213 154091 155184 65010 144195 159963 27173 84912 7922 64924 66035 28231 284111 376497 283375 23568 6508 286256 6522 6581 55974 353189 169026 55867 6527 125206 64116 11309 6561 222962 115111 6546 55532 6556 57835 6547 7781 7780 6574 6576 25800 6568 6567 7779 254428 91749 23516 11182 57181 85414 64849 160728 6717 115019 23382 84102 28965 9356 6543 200010 389812 861 3933 9498 26266 29986 29985 8884 9154 53919 57282 83697 80024 1317 9058 51248 51296 6564 1497 121260 551 4891 30061 9843 1356 84679 6550 6553 389015 6548 6549 10479 285195 6517 23315 23539 9123 9194 133418 29988 57419 25769 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 96%5358752 CTNNB1 T41 mutants aren't phosphorylated 1499 5519 1452 139285 2932 5515 324 5516 5518 8312 5525 5526 5527 5528 5529 SCN4%REACTOME%R-HSA-3282872.4 SCN4 92579 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559585 Oncogene Induced Senescence 1029 2114 2113 192670 3397 26523 6667 27327 7311 4194 7314 7157 23112 7027 1021 4193 1019 57690 192669 1871 1870 2077 6233 5594 7029 7316 5595 1869 5925 1032 1031 4343 1030 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 96%9821993 Replacement of protamines by nucleosomes in the male pronucleus 85236 8349 255626 8341 3021 8342 3018 8347 3017 8348 3014 8345 8370 132243 6732 10361 7290 5620 8340 54145 5619 8970 128312 124512 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation 808 5137 5153 5136 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9031628 NGF-stimulated transcription 1959 6446 3726 2353 7166 8851 6236 1020 2152 4066 8941 3398 2033 429 3399 3397 8061 3400 10221 4664 6722 1785 4665 1108 23237 1961 1960 2354 7425 6457 1958 4209 6938 3727 1386 5978 2002 466 C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine 103 104 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 96%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 29954 1605 10585 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways 808 567 7879 10015 837 7097 2634 5987 3326 2984 9146 6456 4233 7296 8027 6455 2060 79872 7311 1500 1499 30011 7314 999 5045 7322 6457 4843 867 10254 6714 2023 5609 6416 51606 6421 5230 4360 115361 5594 5595 80824 79849 1839 11045 4072 22987 112755 5604 928 127833 5605 9899 6843 9900 4057 6844 6616 163351 6857 6804 3320 3043 3837 3040 2931 5868 11151 1938 57674 1511 26276 2633 6233 7316 3836 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 96%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 1513 122809 1515 861 5275 865 9021 1514 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8931838 DAG1 glycosylations 10329 10559 729920 148789 113829 11041 79147 84892 1605 55624 120071 2218 9215 29954 146664 84197 9486 10585 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME%R-HSA-9005891.5 Loss of function of MECP2 in Rett syndrome 808 3065 79718 25942 814 9612 6907 2874 8841 5566 9611 ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 96%1482925 Acyl chain remodelling of PG 255189 5319 50487 22925 64600 100137049 254531 79888 8399 30814 5320 5322 9926 5321 26279 283748 54675 81579 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function 5959 6017 TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance 8331 51750 8607 8337 8334 8335 8341 23243 8342 8347 26277 8348 8345 25913 5537 8340 3978 23649 55291 8338 5422 85236 8349 5557 5558 890 1017 54386 2237 1616 8370 8290 5440 546 5441 7013 65057 7014 80119 3013 55164 54921 5434 63922 5435 10856 5436 7486 80169 255626 5437 5981 79075 5438 5982 79991 5439 5983 100134934 8900 5430 5431 5432 55135 5433 3021 3018 3017 3014 1736 5111 474382 641 8970 128312 6117 5984 5985 5424 55505 94239 6119 55766 5425 6118 7015 54433 55651 10714 57804 54145 1763 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME%R-HSA-167246.4 Tat-mediated elongation of the HIV-1 transcript 2963 22916 2962 2068 5434 5435 4686 5436 5437 6827 5438 6749 5439 2968 2967 404672 5430 5431 5432 9150 5433 6917 1025 902 51497 11198 25920 51224 6921 6924 7936 6923 7469 904 5440 5441 4331 1022 2071 6829 8178 2966 2965 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) 56659 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%198693 AKT phosphorylates targets in the nucleus 4303 2309 2308 10000 3164 6199 207 208 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones 468 8720 51360 1649 4800 3309 4801 7184 811 4802 22926 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control 7321 84164 10973 53918 6059 6230 6231 6234 9349 6235 6191 6193 6192 6194 7322 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 8453 6161 6175 9045 6210 6176 7415 6171 6170 25898 6173 51065 9861 6205 6204 6233 6207 7316 6206 6209 10213 6208 6188 5706 6187 6223 5707 6189 5708 6222 5709 6224 6181 6218 5700 6217 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 26046 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 6921 5695 9978 7314 6923 5687 5688 5689 90850 22980 9147 23008 55139 55666 7353 7323 GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9953170 GBP-mediated host defense 5045 2635 834 2633 71 5229 2634 2810 5292 60 115361 2342 2339 115362 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-HSA-6785807.8 Interleukin-4 and Interleukin-13 signaling 3566 5743 3911 240 3976 2208 7412 3553 7133 4312 4692 3593 3598 2353 3592 3597 6624 3570 8651 5008 4170 3688 3606 7040 58480 4843 7422 595 3552 6288 3684 2162 1026 3687 3689 4314 6097 5443 7076 948 246 3662 6772 6774 3320 1052 4318 3162 3929 6347 3716 149233 4128 7184 207 5292 3717 4313 5451 3586 4985 332 3718 7297 2308 6778 1901 7431 112744 356 2309 3561 4988 7291 9655 3565 3596 301 6095 9021 2625 3569 3726 3576 3934 3312 604 6356 4582 1278 6657 4609 6367 596 598 3091 6935 7157 3082 5295 2247 3605 10538 3383 79923 2335 7124 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME%R-HSA-190827.4 Transport of connexins along the secretory pathway 2697 2706 2705 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%381753 Olfactory Signaling Pathway 109 2774 56656 120065 121275 120066 283365 390883 390882 390649 390648 124538 283111 4991 4992 4993 442184 442185 442186 79310 79317 284433 57101 341799 219954 219952 121130 79541 79544 121364 125963 125962 4994 79549 4995 283694 121129 219965 130075 219960 390431 390433 442361 390436 390437 390439 341418 79334 341416 79339 219959 219958 219957 219956 283162 138804 65055 138805 283160 138802 138803 390441 390442 390321 390201 390323 390445 390326 390327 144124 254973 144125 79324 283159 219968 127608 219865 219986 219983 219982 390892 219981 401994 401993 401992 285659 1262 81309 79473 1260 81797 390538 7932 219858 219875 219874 219873 219870 390429 79346 79345 26188 81300 26189 219869 347168 26716 286365 283093 283092 347169 138799 390113 134083 391211 392309 150681 338674 338675 340980 283189 219417 219438 219437 219436 26707 219432 219431 126541 338662 403282 403284 127623 254879 283297 255725 219429 284383 219428 126370 219447 390271 390151 390152 391121 441308 390154 390275 390155 441669 390157 390036 390037 390038 441670 158131 138882 138883 138881 23538 390162 219453 390167 390168 347468 219469 219464 338751 391107 391109 338755 254786 254783 10798 390260 390261 219479 390142 219477 162998 390264 391112 390144 390265 391114 219473 390148 79501 286362 390072 390195 390075 390197 390077 219487 390199 392376 390078 390079 219484 219482 392138 127385 143502 119764 119765 143503 81050 390081 390082 390083 390084 26687 119749 402135 26689 219493 81168 81285 392391 81282 392390 504190 1879 390174 390054 26533 256892 390058 26532 390059 26534 26658 26539 26538 26659 26531 343173 390181 390061 343172 343171 343170 390063 441639 390064 389090 390066 390067 26664 343169 81061 390190 390191 403274 127062 403277 403278 127069 127068 127066 127064 403273 120787 119687 81099 119682 26529 441933 127059 26648 120775 120776 119678 9355 119679 390093 392392 403253 441608 403257 391189 26735 128371 26737 8590 128372 391190 196335 391192 346525 391191 391194 391196 391195 403244 128366 128367 128368 128360 119774 119772 26740 403239 346517 79490 81328 120586 256148 81696 81697 8387 8388 8386 8383 81318 79482 81448 81327 81442 132112 393046 8861 8390 8392 122742 26494 401427 26493 26496 401667 401666 282775 122740 401665 26497 81470 81472 282770 341276 122748 127074 341152 256144 127077 283617 51764 120796 81469 119694 119695 120793 81466 282763 81341 343563 119692 387748 344892 79290 79296 135924 79295 26595 26476 284532 125958 442191 26246 442194 26248 442197 81127 26245 284521 135941 26339 26338 135946 26219 135948 26692 402317 26693 26333 26696 26212 81399 26211 81392 388761 2782 343406 26341 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog 8452 83737 64750 79577 10956 5034 2932 27248 147111 51009 51684 6400 5567 5568 111 112 113 114 115 2737 156 2736 7289 374654 80199 9742 55811 23432 23322 2735 27152 57154 84447 79659 5575 5573 7415 51098 9861 5577 8454 6233 7316 5576 10213 5706 196883 79809 5707 26160 5708 5709 5700 5701 5702 107 5704 108 5705 109 5682 5683 8650 5566 408 5684 409 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 57539 5695 9978 7314 6500 5687 5688 5689 55081 85455 55733 57758 50937 2262 64399 91653 2619 55764 8100 6469 22873 25989 339745 132884 2121 23288 2622 84455 50846 11127 6608 57728 8481 8405 1452 54903 6868 3549 2778 5727 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection 3553 9051 834 718 4790 10628 4210 5025 3326 3162 7295 3606 4791 5027 79792 5970 10910 1511 4907 3552 29108 114548 953 957 719 HYDROLYSIS OF LPC%REACTOME DATABASE ID RELEASE 96%1483115 Hydrolysis of LPC 123745 79887 255189 5321 283748 56261 23659 100137049 8605 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors 727 718 1234 4852 1908 1906 5443 4157 1910 4161 4160 1524 4159 6387 51083 7852 729230 1230 10663 1238 719 1237 1236 1235 1233 1232 4985 4987 3792 2587 351 4886 4887 10850 4889 2359 2357 3579 4986 3577 4988 56477 5660 6751 5540 6752 5539 116512 643 6755 6754 301 8811 5697 256933 7504 5473 4142 8862 51052 9718 4283 6346 4158 5368 10563 6351 6352 6354 6357 6356 6348 6349 6361 6364 6363 6366 6367 6360 6373 6372 6374 6376 6370 5173 5179 6750 51554 58191 2919 2921 2920 8484 186 187 2826 2834 2833 4295 2832 7200 2831 7201 57007 283869 1909 57486 2852 10803 50865 1907 1889 5196 2861 84432 9034 9283 6375 2693 84109 10874 1325 2532 3627 10887 10886 257313 6288 387129 2358 2922 6846 2925 6863 183 185 623 624 56923 6870 2151 2150 2149 2147 6865 2829 6866 6869 885 886 887 2837 347148 9002 3814 10911 594857 64106 6347 6753 3827 129521 128674 2862 60675 4922 4923 8620 680 84634 3060 5367 23620 3062 3061 10316 4828 4829 84539 2847 5020 551 5021 552 553 554 27202 3576 728 51289 3640 10022 122042 117579 6019 339403 59350 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447041 CHL1 interactions 3672 3673 8515 10752 286 3688 8829 3312 27255 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 96%453274 Mitotic G2-G2 M phases 51400 51451 90381 79596 728642 63943 984 79866 51512 6790 55320 891 983 55355 5347 9088 22974 85378 10426 29922 27229 440145 1017 80097 55835 1871 114791 10133 27175 2305 653784 51343 10844 7465 286826 132660 1026 91750 1869 55957 8655 1063 151648 10142 23332 5500 2033 22919 3320 5048 5520 7840 11064 7514 22994 9133 22995 84962 7283 203068 55722 1453 54820 7532 9738 11190 28227 1781 95681 1778 1069 9861 5577 8454 6233 7316 54801 9793 10540 5928 10213 4218 5706 23291 5707 5708 11116 5709 5519 5700 5701 5702 5704 5705 54930 7531 5682 5683 5566 5515 5684 79959 5516 993 5685 5518 994 5686 995 5717 93323 3326 5718 5719 8945 22981 11047 5713 5714 7979 80254 5690 55755 5691 10806 5692 5693 5694 10121 7311 5695 9978 7314 80028 6500 9662 890 5687 5688 5689 10733 80321 55125 9814 4331 1022 115106 79441 9702 5108 55142 10383 22897 8900 10382 5116 80184 23194 902 7846 23354 8481 22822 121441 7277 7157 55559 1454 3161 8636 4751 11258 84131 4957 4659 4605 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 96%418457 cGMP effects 5593 5152 10242 5138 10335 3708 27094 3778 3779 10846 5153 27345 50940 5136 8654 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8932506 DAG1 core M1 glycosylations 29954 1605 55624 10585 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases 8331 4086 8607 8337 4087 100287327 440689 4088 7874 8334 4089 8335 8313 93624 8678 10868 90865 8341 64750 10869 8342 8347 6478 4092 8348 8737 8345 329 83844 8340 7186 9146 79589 10600 23326 8338 330 85236 8349 100287178 9099 27005 5728 10254 10454 7375 11274 7189 1540 8239 8724 6502 100287144 3416 23770 6314 91833 100287364 9097 3013 154 64135 63891 5423 991 255626 23586 63967 3018 3017 1643 9958 9736 100287513 55288 9101 401447 57599 8312 8970 317772 128312 92815 85235 8969 221613 8295 23032 79594 9738 100287238 100287478 9868 728386 57646 100287205 9861 100287441 6233 7316 100288520 10213 6885 5706 5707 100287404 5708 55031 5709 57695 5700 5701 25862 5702 5704 6881 5705 5682 55611 5683 8975 81847 4792 408 5684 409 9100 993 5685 8658 80351 5686 5717 5718 5719 11047 5713 219333 5714 7979 64426 5690 5691 7417 5692 5693 84196 7416 5694 9960 7311 4194 7419 5695 7314 890 5687 7046 4193 5688 8517 5689 51651 84101 9986 377630 392188 367 9817 2625 23358 84132 645836 9804 29761 8900 645402 10474 7353 8078 728419 4609 4303 3091 2648 27430 7157 1080 84749 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis 23460 5825 10347 20 10350 5824 64137 215 23461 8504 225 64241 64240 26154 335 10349 21 9619 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) 6559 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 96%6807505 RNA polymerase II transcribes snRNA genes 22916 6908 4686 6827 6880 6882 6884 1025 6878 6877 8812 2959 2958 2957 2961 2960 65123 57508 80789 26173 904 55726 905 51585 5452 55756 64859 26512 23248 25896 80237 79035 79664 29101 22936 81556 55656 5440 79871 23379 5441 54973 92105 55174 1022 57117 55197 6829 84524 58490 2963 2962 5434 5435 5436 5437 5438 5439 5430 6621 5431 5432 6619 5433 7702 6618 10302 6617 6667 51808 5451 51593 8178 129685 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 96%193692 Regulated proteolysis of p75NTR 4804 5970 23385 51107 4790 7189 6868 5663 5664 55851 83464 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111469 SMAC, XIAP-regulated apoptotic response 331 317 842 836 54205 840 56616 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes 91289 344 5045 4023 5046 84699 5125 116519 8720 51360 337 27329 26291 55908 338328 3990 64788 51129 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling 808 2770 2773 3276 2353 1956 7039 2309 2100 2793 6714 2792 595 340481 4893 2791 2790 858 4316 3265 55625 2788 2787 2786 1027 2785 2099 2784 5594 5595 685 127933 2783 255324 2069 51764 94235 2002 4314 1839 55970 3320 54331 4318 3480 59345 6722 374 596 1903 10000 1950 5747 7514 857 346562 5590 207 208 5295 5296 6801 2782 8877 8503 5290 5170 4846 4313 10681 2771 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 96%9013973 TICAM1-dependent activation of IRF3 IRF7 7314 7098 3665 7187 9641 148022 10010 10133 29110 6233 3661 7316 7311 MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing 10898 81608 3192 5499 4904 57794 5500 22826 22827 10262 11325 10236 55749 8106 23524 9879 6233 10181 7316 5093 5094 6434 1660 51593 84844 1655 22916 3183 4686 8175 5930 27316 10992 79869 5725 10523 4670 9584 6631 10929 8189 7311 10772 11051 6625 6627 10978 6626 6629 1479 7314 135295 220988 51692 64852 1478 1477 10915 9785 23283 6430 58517 23450 10914 6432 27336 23451 6431 53981 55660 9984 51585 5511 10250 29894 5514 55339 6638 22794 57187 51362 7919 199746 84324 84248 6427 6426 84321 5440 6429 5441 9939 6428 10212 3178 9877 51213 3181 10189 3188 84271 3187 65109 3185 80145 2963 3184 26097 2962 8563 5434 8683 5435 22803 5436 9775 3191 5437 3190 9295 5438 10921 5439 10569 51639 11338 55110 5430 79228 5431 4116 5432 64895 7307 5433 10291 8241 23350 10285 10946 6632 6628 1665 84991 6634 2521 6633 83443 6636 6635 6637 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9034864 Activated NTRK3 signals through RAS 4908 4916 4893 6654 3265 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME DATABASE ID RELEASE 96%9636249 Inhibition of nitric oxide production 3837 4843 3836 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 96%380108 Chemokine receptors bind chemokines 2826 2833 1234 57007 10850 10803 5196 9034 3579 6375 3577 56477 3627 643 6846 5473 4283 6346 3576 2829 10563 6351 6352 6354 6357 6356 6348 6349 6361 6364 6363 6366 1524 6367 6360 6373 6347 6372 6374 6376 6370 6387 51554 58191 2919 7852 2921 729230 2920 1230 10663 1238 1237 1236 1235 1233 1232 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis 5443 1586 6715 6716 3284 3283 79644 3293 3972 51144 1081 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 96%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 29954 1605 10585 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen 11093 7450 2812 2815 2811 2814 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate 8566 316 55163 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 1544 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME%R-HSA-9907570.1 Loss-of-function mutations in DLD cause MSUD3 DLDD 594 1629 1738 593 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 96%350864 Regulation of thyroid hormone activity 1734 1733 1735 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 96%171319 Telomere Extension By Telomerase 51750 55505 80119 8607 55164 7015 890 10856 54433 1017 8900 54386 55651 55135 23243 26277 25913 5537 1736 7013 65057 7014 55291 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) 5591 8924 8341 8342 8347 8348 8345 8340 85236 8349 7336 7334 8370 8290 51588 255626 7468 29086 9025 51720 472 672 84142 165918 7158 3018 3017 3014 9577 79184 8970 128312 22976 55183 9656 27343 51567 7518 79840 55775 3981 64421 27434 10111 4361 54145 4683 580 7520 10524 2547 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy 7879 80824 GASTRULATION%REACTOME%R-HSA-9758941.6 Gastrulation 7004 4087 4088 4089 5080 8463 3170 9794 1499 999 10046 5077 7545 22938 84441 8320 64321 6862 2033 145258 83881 2627 83439 51176 2043 1387 7852 7022 2294 7021 9861 10213 5706 7020 6615 5707 5708 5709 3169 5700 5701 5702 5704 5705 5682 5683 5684 5685 51592 5686 5717 5718 5719 8850 11047 5713 5714 7979 5690 5691 5692 5693 5694 4851 5695 5687 5688 5689 1749 9241 6469 130497 2296 2626 387332 2303 344022 652 134701 4487 5081 84667 3975 5076 343930 3955 145873 10683 25925 5453 5015 6656 2253 6911 6657 2260 2637 9839 7849 10413 7546 2648 89780 28514 8928 2249 2247 3549 3516 5460 79923 4602 6932 6934 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter 10621 5434 6908 5435 5437 6621 55290 6619 7702 6618 10302 6617 51082 84265 55703 11128 51728 9533 27297 661 5440 10623 5441 171568 55814 5451 55718 10622 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME%R-HSA-9842860.2 Regulation of endogenous retroelements 8331 8337 8334 22880 1107 8335 53615 8341 8342 8347 8348 8345 197320 65251 1108 8340 162967 162963 8338 25799 1788 85236 8349 284306 3066 86 8370 6595 57504 6597 6599 9112 6598 3013 3065 255626 8110 7695 6601 8193 6603 26039 55729 6602 6605 5977 6760 3021 8289 3018 3017 3014 9274 9275 57693 605 9869 474382 57459 7700 8970 128312 54815 55766 6604 8968 9422 653604 5928 29947 23468 147646 90853 10155 155054 79813 147686 9219 6940 10919 81931 91661 7767 54737 125893 147658 57492 7329 6613 55422 90075 84911 10793 113835 60 10179 79862 55596 5931 23272 7562 51535 94239 7576 143689 340252 285676 162655 23517 54145 7581 SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 96%9703465 Signaling by FLT3 fusion proteins 2804 9321 399687 4893 6654 6711 3265 50507 2120 5295 6777 6776 5292 5290 1026 9846 7750 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 96%397014 Muscle contraction 5062 9424 3775 10089 10008 23704 9992 23630 3753 7273 4878 302 3751 3752 56659 3757 3770 88 338567 25937 3776 3777 51305 8654 808 3784 29766 83795 54207 7431 50801 6910 11280 1482 8850 3750 89822 3741 55800 7169 6324 7168 6323 493829 10174 8291 25802 4629 58498 2983 2982 93408 859 3693 10580 7170 6331 7171 6330 2977 6332 301 6335 10627 6334 29895 140465 800 6326 8912 8913 6328 8911 6327 309 6329 4636 103910 4637 4638 6336 3761 59285 775 3759 2259 29098 2258 2257 2256 3768 27092 9254 782 783 59283 3672 8645 56660 60598 30819 30820 80333 217 1066 30818 4311 10142 59284 1756 476 477 478 6546 53822 4842 6547 3710 53826 5350 10060 53828 7137 80228 480 1193 481 2281 482 483 486 487 488 444 489 84876 5348 5349 10345 3767 6717 490 491 492 493 815 7414 816 817 818 6263 6262 10398 6588 6786 6543 6261 10768 3708 7094 3709 1760 5566 204851 4880 4881 4882 10699 2626 89 7125 8557 29767 7140 4606 4607 29765 28996 1674 4621 7139 4624 4604 4626 4703 7134 7111 7220 7136 7135 5829 7138 4632 4633 4634 4635 5058 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME%R-HSA-9865113.1 Loss-of-function mutations in DBT cause MSUD2 594 1629 1738 593 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME DATABASE ID RELEASE 96%8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 23112 26523 57690 192669 192670 27161 27327 4343 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9035034 RHOF GTPase cycle 9341 55971 394 1729 85360 7879 4001 445582 81839 60 87 23344 120 94134 23380 857 55789 65124 4162 4650 7112 80728 81624 29843 10160 5295 55240 5296 832 8773 8776 54509 26092 9497 1730 26049 9590 10409 9743 80115 57584 392 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-HSA-9734009.2 Defective Intrinsic Pathway for Apoptosis 1029 7157 708 84290 5052 7001 4001 7531 8851 1020 351 2801 10018 993 994 356 995 831 823 824 826 6648 2309 3725 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 96%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 89780 7474 54361 7483 4040 22943 4041 27121 79412 83999 27123 11197 50964 6423 6422 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import 8604 10165 80273 9512 23203 27235 7416 2671 100272147 10531 400916 498 3313 6901 56942 92609 10651 197257 516 29928 51142 3329 51025 4580 134266 2395 79145 54543 25813 3421 9804 29090 10245 26519 5009 26515 26517 617 506 51287 150274 54927 50 1537 10452 90639 10063 26521 10469 26520 100188893 100287932 1678 401505 84269 56993 1431 131474 131118 388753 10440 4714 9868 291 293 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport 1601 2017 84251 1294 29127 81631 26119 10987 53632 4952 6814 5879 160 5874 161 163 213 57679 1175 1173 3949 154 10093 10092 5563 6678 5564 10094 5565 10097 10096 5571 1129 10000 1856 4124 84364 2799 55576 1362 7532 11311 4641 207 208 4644 9685 7164 388552 10109 9332 7163 8976 6272 4627 286451 6643 27131 55330 54885 152503 10552 26258 2804 3630 84062 9698 1176 64746 23557 57134 4121 10905 10525 22878 22879 221960 79890 2665 8867 80006 2664 25782 23682 57706 10260 6764 11031 23258 9909 1639 79961 116442 84315 2697 60684 23011 2706 10981 5866 84079 160518 163259 126432 22930 22898 22931 54453 11015 55667 27147 3257 54734 51622 79958 259173 89781 201627 9610 163486 414918 201475 1122 51112 1278 1277 286133 8685 4481 117156 81035 4905 10945 23048 54874 55860 51164 2890 10671 636 23299 93661 5050 84516 5049 57369 10052 84694 1213 1211 6288 10133 811 948 8546 5873 3320 2589 1453 3092 22920 2590 117177 6233 7316 10540 4218 9525 51160 55048 89853 23265 11267 51028 155382 137492 27183 93343 7251 1956 51271 7039 79720 378 84313 60412 51510 51534 54536 2810 9371 10121 10640 7311 11336 7314 149371 6305 8578 55763 3797 8729 56894 2705 55770 9321 127534 219770 11127 125111 375519 2702 2701 2700 8766 2709 2707 2703 10804 57165 81025 57186 79058 57148 10890 5872 23216 6517 9882 51552 9847 11258 1080 4035 9341 23647 22836 8907 8774 8775 130340 3482 79571 22796 10053 1174 7879 9382 8905 57589 10139 162 51560 143187 10652 164 10618 3998 60592 51209 25839 5870 22818 9712 26286 90196 10228 22820 122830 84316 6453 83548 400 63908 9146 57511 6456 1121 60560 10466 8027 9827 6455 374403 2060 11021 9367 8674 9363 8677 84958 8675 23062 30011 339122 57465 23163 6293 6457 51762 2800 867 79735 51542 10254 84342 27342 738 4122 83874 91949 83452 2803 4943 11345 7110 55275 8408 10244 9135 23637 9648 729873 338382 6811 64786 125058 11316 9230 5898 54662 6280 26088 26000 55357 51256 57533 7534 10971 5867 11337 7533 9609 8398 11070 7529 347517 3043 10226 11014 3040 5878 5868 335 5869 338 9276 1315 922 1314 284297 808 26958 5052 7531 9318 4646 51014 351 23423 24137 2801 51272 4253 2873 51138 1759 6708 6709 285643 286 287 288 7248 51332 6711 6710 6712 372 381 9527 26052 7249 685 54732 255324 2069 51226 1839 57731 127833 8673 4074 2647 1777 6844 375 1212 3312 6857 10717 6845 8906 9179 23431 134829 157807 81567 1522 348 1785 11154 51128 9829 27314 5864 9871 8322 9632 10427 7474 1523 10802 10484 6572 8533 1604 64708 92421 27243 10980 128866 9267 9342 50813 9265 9266 27128 250 9950 10920 27333 79643 51652 3512 259 3263 8542 3240 3250 29082 9585 55083 23046 91782 55605 113220 6810 25978 3833 3834 90990 55850 3146 23095 10749 60561 830 55614 832 146909 6836 55582 23166 23303 124602 53407 64147 829 221458 662 51594 547 185 8655 3798 3799 9183 375056 1062 6869 5321 5048 156 51143 7184 6396 10808 1781 1780 78989 1778 81930 81846 84643 3796 5648 64837 1783 26153 147700 10112 9493 3831 3832 3835 140735 56992 79090 408 5265 89953 11004 409 6399 5861 23243 22870 2153 22872 2348 10175 5537 377 10972 9554 9117 11196 64689 126003 55291 23256 1075 58485 254263 25956 55014 81562 51693 2157 551 122553 8615 966 554 10342 27095 149111 9919 81876 83696 10959 10113 90411 4738 10282 7082 4012 26984 2512 9570 51399 89866 79748 7109 128637 10960 2495 7018 7037 23208 9185 9856 8301 115548 374 1861 55738 5286 915 1950 27348 23149 29924 917 26130 85439 29763 51429 9892 920 50618 22905 2580 382 25977 3267 23396 9026 29988 51422 273 274 58513 157 950 1284 1282 143425 22848 1281 8773 29993 8218 8871 9322 4036 286749 3575 90019 55707 11252 112574 29978 29979 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex 54107 56655 84515 5000 5001 23594 23595 4998 4999 990 4172 4173 4174 4175 4176 23649 6117 5422 8318 4171 6119 5557 5558 8317 6118 5426 5427 1017 29935 10926 81620 51053 55388 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 96%5250958 Toxicity of botulinum toxin type B (botB) 127833 6844 6857 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 96%1614603 Cysteine formation from homocysteine 875 1491 DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME DATABASE ID RELEASE 96%5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 23636 9972 5903 9631 7175 11097 2646 23511 8086 8021 53371 8480 10762 348995 79902 57122 2645 55746 23279 79023 6396 9883 129401 9688 23225 4927 23165 55706 SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants 83999 27123 22943 4041 27121 79412 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade 721 727 629 717 718 1991 966 1378 3080 4179 5627 1361 1380 10877 10878 730 731 27202 710 732 930 975 733 2147 735 81494 3078 3075 1370 1191 3426 1369 722 725 728 729 4153 2220 1401 1675 3004 712 78989 713 714 8547 715 10584 716 5648 2219 719 1604 7448 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 96%69190 DNA strand elongation 5981 5982 5983 84515 3978 5111 4172 4173 4174 4175 4176 23649 64785 6117 5422 8318 5984 9837 5985 5424 84296 4171 6119 5557 5425 51659 5558 6118 10714 2237 57804 1763 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway 64135 89122 23586 80143 3456 3665 84282 7187 57506 9641 2033 1387 7706 29110 3661 DEFECTIVE B3GALTL CAUSES PPS%REACTOME%R-HSA-5083635.4 Defective B3GALTL causes PpS 145173 57188 10417 10418 170689 171019 54437 9510 9037 5199 7058 157869 7057 9507 80070 140766 9508 9509 339366 221981 79875 81794 55901 81792 9719 56999 11093 11173 11096 11095 11174 80731 170690 54507 170692 92949 170691 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 96%450282 MAPK targets Nuclear events mediated by MAP kinases 1849 1848 1846 5519 1845 2353 5599 5515 6197 6196 5516 5518 3725 5528 4208 4205 9261 5601 6195 1432 5602 9252 1386 5594 5595 5598 2002 466 51231 5600 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body 4036 26119 6947 51293 6948 5826 55788 4363 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses 2990 3373 2799 4669 3425 2588 138050 2720 411 3423 6448 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency 7172 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 9971 9420 10499 1593 1581 10998 1646 6718 1645 80270 11001 1109 3295 10005 6256 570 1582 8309 8647 8648 8644 23600 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%R-HSA-2474795.5 Diseases associated with visual transduction 2652 5956 24 5959 145226 7276 611 64220 5950 9227 6017 5947 222236 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 96%1227990 Signaling by ERBB2 in Cancer 5782 2064 1956 4893 6654 3084 3265 5295 3320 55914 9542 5290 5335 10718 145957 2549 6464 685 1950 11140 2069 1839 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8849175 Threonine catabolism 10247 113675 10993 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex 3065 7027 1875 1874 993 7153 286826 4149 132660 91750 990 5111 7029 4609 55957 1869 5928 5933 5934 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-HSA-170670.5 Adenylate cyclase inhibitory pathway 2770 2774 2773 107 108 346562 109 111 112 113 114 115 196883 2771 TRANSLATION%REACTOME DATABASE ID RELEASE 96%72766 Translation 7321 8893 1965 8894 8891 8892 6185 1968 7322 8890 1967 6184 51520 1615 5859 4141 3376 7965 9521 5917 3735 9255 2058 90701 23708 1650 8453 2107 28972 26986 2935 7415 23478 58477 6745 6921 9978 6923 1975 4512 4513 4514 1978 1977 6734 1981 23438 57176 25973 55157 80222 10667 79731 79587 51067 55666 55699 124454 23395 27068 57038 92935 10352 54938 57505 2617 7353 9789 4706 54516 9617 84340 4540 4541 7323 29104 4535 4536 4537 4538 51504 4539 92399 60559 84164 10973 53918 6059 6230 6231 6234 9349 6235 6191 6193 6192 6194 55176 51121 6746 6748 6227 6747 6229 6731 6228 29927 6730 6729 11224 23480 6726 200916 6122 6728 6124 10952 6727 6123 23471 6125 25873 140801 3921 4736 6130 6133 4508 1974 6132 4509 1973 8662 6135 8663 6134 8661 6137 8666 6136 8667 6232 8664 6128 8665 6129 27335 3646 6142 6141 51386 7458 6144 8668 6143 8669 6146 6147 10480 1964 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 6175 9045 6210 6176 6171 6170 25898 6173 51065 9861 6205 6204 6233 6207 7316 6206 6209 10213 6208 6188 5706 6187 6223 5707 6189 5708 6222 5709 6224 6181 6218 5700 6217 5701 5702 5704 5705 5682 5683 5684 64432 65003 5685 64951 65005 5686 65008 5717 28977 5718 5719 90480 51081 26046 11047 7284 5713 6150 1983 5714 9669 55168 64949 7979 28973 5690 65080 5691 51642 5692 5018 5693 54998 5694 10573 7311 11222 5695 128308 51649 7314 9553 64960 5687 5464 92259 63875 5688 64963 64965 5689 64968 55173 55052 64969 327 51373 26284 51650 60488 51253 51258 219927 29074 10102 56945 64975 90850 28998 64976 22980 79590 9147 64979 23008 64978 55139 23107 28957 64928 7818 57129 51263 29088 51021 54534 51023 51264 51069 84545 85476 4519 78988 122704 65993 64981 10240 64983 3396 26589 63931 6182 54460 6183 118487 51073 116540 740 124995 54148 1938 116541 1937 55037 1936 29093 1933 9801 54471 1917 51116 7453 1915 10884 16 54948 8565 51318 91574 123263 833 10056 4528 4677 219402 51250 115416 3035 6897 2193 7407 6301 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-HSA-176187.4 Activation of ATR in response to replication stress 5982 5983 3364 63967 84515 5000 5001 993 84126 23594 144715 23595 4998 995 5810 4999 990 4172 4173 4174 4175 4176 6117 8318 5984 5985 4171 6119 8317 6118 5883 5884 1017 10926 1111 55388 545 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME%R-HSA-9931530.2 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 1454 5499 1453 1020 5500 5187 1460 8864 1459 8863 1457 1408 1407 5501 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF 10787 8936 5062 117145 10152 2185 5921 14 3071 10163 653361 2475 63916 10006 1500 1499 1793 5879 7422 9564 4893 79109 3265 3791 23191 9261 558 1432 1398 9844 25759 2277 6300 998 5600 7867 5603 55615 5567 5568 7424 7423 3320 10810 5580 64223 10000 3685 5747 5578 8440 3710 857 7410 207 208 7409 4690 26999 10451 4846 8829 1495 9047 5579 6461 2534 808 2324 6093 3690 10768 3708 3709 5566 9475 8828 2321 1003 5335 5228 3315 5829 253260 57761 5590 387 5295 5296 5058 8877 5290 5170 5291 1536 3728 1535 10458 4688 55845 4689 5063 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 96%888590 GABA synthesis, release, reuptake and degradation 10815 6529 6844 6540 6616 3312 6539 6857 6804 2572 2571 22999 6538 18 140679 7915 5864 80331 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702605 pexidartinib-resistant FLT3 mutants 2322 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME%R-HSA-9022537.2 Loss of MECP2 binding ability to the NCoR SMRT complex 79718 9612 6907 2874 8841 9611 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters 6521 57835 9497 57282 83697 9498 8671 6508 23382 6522 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-HSA-168928.12 DDX58 IFIH1-mediated induction of interferon-alpha beta 1147 55593 7321 3665 4790 351 4792 83737 4793 841 3326 8737 9246 7186 7318 4791 7311 5970 3093 7314 7322 3551 84166 6285 8517 6288 7187 9641 7189 6283 1540 3146 10010 7128 4214 8887 28512 79671 177 28511 9636 64135 3442 3441 3440 23586 80143 3456 84282 57506 3452 3451 3449 3448 843 51191 3446 3445 3444 3320 2033 3443 7706 29110 3661 5300 7323 89122 9868 1387 79132 54476 26007 54941 9140 9474 6233 7316 5094 8772 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation 2353 5062 5599 5335 3725 4067 5879 9402 4893 7410 6654 3265 5609 4214 7409 6416 5601 5058 5602 10451 5336 5594 3937 5595 6850 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins 23636 6613 9972 5903 9631 7175 11097 10210 23511 8086 8021 53371 8480 10762 348995 79902 57122 55746 23279 79023 6396 7341 9883 129401 9688 23225 4927 51588 23165 55706 7329 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 96%380994 ATF4 activates genes in response to endoplasmic reticulum stress 468 3576 1051 5393 11340 22894 23016 8570 23404 5073 51010 54512 1649 51013 56915 4800 118460 4801 4802 440 6347 9709 3484 1054 167227 22926 467 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME%R-HSA-168271.5 Transport of Ribonucleoproteins into the Host Nucleus 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 10762 348995 3837 79902 57122 55746 23279 79023 6396 9883 129401 9688 23225 3836 4927 23165 55706 MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME DATABASE ID RELEASE 96%9816359 Maternal to zygotic transition (MZT) 25904 8331 7004 8337 8334 8335 55571 27161 8341 8342 8347 8348 8345 85456 7290 246175 8340 8338 57472 85236 8349 9337 1975 10765 1977 8370 678 1981 29883 132243 390748 1974 54766 10361 5620 1973 5619 200424 29128 5927 359787 124512 23135 57379 7403 285051 9125 3013 9775 255626 3021 3018 2033 3017 3014 6732 23318 390245 23405 100288687 474382 129563 201516 79670 503627 8970 503835 10413 128312 55211 342900 100033411 8106 151871 94239 284355 55766 7157 10605 8968 26986 23019 653604 1387 4850 4848 54145 4849 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling 64135 55593 7321 23586 84282 57506 51191 83737 7706 29110 9246 3661 7318 5300 7311 7323 3093 7314 89122 7322 84166 7187 9641 1540 8887 7128 54476 54941 9140 79671 9474 6233 7316 5094 9636 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases 835 58484 7161 317 8738 7157 839 8626 834 472 843 55367 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC 60 10693 22948 10574 10694 10576 908 10575 6950 7203 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 96%194441 Non-coding RNA Metabolism 23636 22916 5903 9972 9631 7175 11097 4686 23511 8086 8021 53371 8480 10762 79902 96764 348995 57122 55746 23279 79023 6396 50628 6632 10419 6628 51808 79084 79760 54960 9883 129401 6634 6633 9688 6636 6635 6637 25929 23225 10073 4927 79833 6607 23165 8487 11218 55706 1207 RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9833110 RSV-host interactions 51586 6382 9439 400569 7297 55090 7097 6773 10001 221914 23097 8678 9672 8341 2239 3454 9246 6837 9477 112950 29079 7311 10134 6921 9978 7314 3339 6923 81857 929 219541 2262 25820 54797 10332 10333 2817 9862 90390 9636 8065 64135 3442 3441 3440 2719 23586 3456 55588 57506 3452 3451 3449 1024 80306 3448 51191 3446 3445 3444 23389 2033 3443 9282 7706 23643 1524 9968 5610 3661 9969 4131 3716 51003 7098 51284 7099 84246 4939 1387 9443 30835 5469 9441 9412 9442 6233 7316 10025 6383 9440 10082 6385 375790 892 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing 2963 22916 2962 5434 5435 4686 5436 5437 5438 5439 5430 5431 54845 5432 5433 5725 4670 23543 5440 80004 5441 7073 7072 3178 3187 3185 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex 6604 6601 6603 6602 6605 86 53335 5977 8289 6760 9274 60 9275 605 55274 64919 6597 6599 6598 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME%R-HSA-9933937.1 Formation of the canonical BAF (cBAF) complex 8110 8193 26039 6602 6605 86 5977 8289 6760 9274 60 9275 605 57492 6595 6597 6599 6598 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%73863 RNA Polymerase I Transcription Termination 2068 5434 6908 5435 5437 2968 2967 404672 902 221830 7343 25885 9014 9015 9013 64425 7270 79101 10849 30834 84172 51082 9533 5440 5441 4331 1022 2071 284119 2966 2965 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants 808 10256 817 54518 818 8826 22866 7529 7450 3690 5604 5894 5605 5037 2243 7094 5908 369 283455 408 409 3845 6714 4893 3265 673 4140 5594 4296 5595 8315 2335 5245 3717 2244 1445 2266 5906 7414 815 3674 8844 816 O-LINKED GLYCOSYLATION%REACTOME%R-HSA-5173105.10 O-linked glycosylation 93010 148789 10678 22915 23275 2589 9486 10610 6483 6482 6484 6487 6480 10331 256435 113829 27090 11041 84892 1605 120071 8693 2590 55568 442117 374907 2218 84002 11227 11226 374378 51809 64409 84752 140687 9245 114805 2650 168391 192134 63917 117248 51146 79812 146712 51301 26290 50614 57452 79623 10164 84197 7057 170384 10559 10329 729920 9334 9331 145173 57188 79369 2591 143662 79695 10417 118430 10418 170689 171019 79147 54437 9510 129080 9037 4582 5199 4583 84750 7058 4584 4585 4586 200958 157869 29954 727897 56667 29071 9507 80070 10585 140766 9508 9509 10071 94025 339366 221981 79875 81794 140453 55901 4588 4589 81792 55624 283463 9719 56999 56913 11093 394263 11173 11096 11095 11174 9215 80731 170690 146664 54507 170692 92949 170691 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9026519 Activated NTRK2 signals through RAS 4909 627 4893 6654 3265 4915 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%379716 Cytosolic tRNA aminoacylation 7453 16 8565 5464 833 5917 10056 4677 2617 3735 9255 3035 6897 2193 7407 51520 1615 5859 4141 2058 3376 6301 7965 9521 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 96%6798695 Neutrophil degranulation 240 4317 7133 1729 718 1088 8972 12 1118 3071 1 5175 64386 101 10577 5879 967 140885 161 4973 11001 6518 30 5663 5768 1084 6402 51411 23385 197 965 5777 84061 64333 10092 3417 10097 23526 5004 978 4318 6993 230 2548 5005 10326 2268 51125 2683 1511 10450 1650 684 2799 8778 2212 29108 7415 54509 27180 5834 5836 719 158747 126014 10855 11026 7097 2588 28988 23197 23601 2444 960 2665 3101 3107 3106 3903 11031 178 10288 3683 55276 22931 10694 84329 10576 10383 4057 847 2934 5211 5223 4125 4126 1654 6515 210 2992 55860 5049 5236 5788 57126 4718 51071 226 929 353376 7305 6283 6727 170482 338339 945 11314 948 3304 4860 272 353 5873 3320 353189 3837 5611 23200 1265 6556 79895 4282 203068 9588 2950 1727 9861 10213 5707 5708 5709 5701 5702 4790 5683 8876 5686 5717 5718 5719 2821 23250 5713 196527 1823 10396 5695 121260 5689 5023 327 9218 5315 3958 10555 79888 80184 51316 138050 634 10890 427 7226 51552 387 22875 374395 3920 10549 391 201294 1116 2204 1476 80301 932 8907 10875 820 3482 5657 2352 567 116844 26 387263 7879 10857 5337 3608 114790 124583 388698 963 388697 968 51209 83716 10788 5870 127829 4332 10493 160364 79930 9798 8804 23218 5553 5795 5787 5547 4353 25840 374403 56954 11322 5799 1794 23317 55754 8836 11333 8987 23406 64114 89777 57826 4893 566 6317 9961 8993 23191 4033 25801 3684 221 56888 55313 1432 8635 6279 683 10321 6280 1378 961 9725 8694 3687 10562 3689 441864 5594 6590 2171 84443 51646 5273 326624 54918 5036 29952 5906 199675 5284 154664 9522 9535 8560 6036 6278 6037 55 6286 25798 401258 25797 7130 6282 387921 383 10394 11240 175 150372 3043 11010 23593 10043 100049587 3916 51806 5878 222487 83858 5869 302 22918 3685 2717 1992 80142 8288 9145 57020 258010 1774 84766 2760 53916 3848 53917 84514 1315 79169 94103 26578 5912 5806 23071 84418 2896 3615 3614 4831 2215 1509 10487 5478 6093 56729 5329 3326 823 2357 5476 3579 3577 8514 6709 57153 317 51719 5660 8621 9761 55004 8649 4758 9545 28956 29099 23114 5473 23412 8673 6616 3312 5199 2517 81567 1522 976 5864 80331 8895 2919 47 84658 8904 1604 4257 9342 25852 2990 51816 3074 2720 411 79792 10533 3240 1991 5724 4069 1471 6386 2358 3146 7276 81619 6836 728358 10075 5645 5646 1669 8655 2519 7077 4311 290 10159 5580 671 51143 1520 1508 1675 8566 1778 6947 2219 23352 7520 2547 7414 3310 1512 8826 10120 340061 5908 5265 4048 79980 93100 1075 58485 410 966 3163 1832 1828 2512 5317 527 5269 5328 2495 51382 535 10312 3934 728 55832 1460 1143 1938 1915 6793 102 53831 10970 8773 2040 1536 3728 54472 1535 2207 4680 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 96%4570571 Defective RFT1 causes CDG-1n 91869 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport 83657 3842 150737 9321 57560 200132 57576 83658 140735 56912 51668 255758 11127 57728 51626 90410 9371 55112 6991 64792 26146 92104 9742 57539 79989 89891 11020 80173 55081 79659 23059 22920 55764 51098 3797 28981 8100 112752 8655 79809 26160 APAP ADME%REACTOME%R-HSA-9753281.3 APAP ADME 7366 124975 445329 2686 95 54600 54578 27233 54575 6822 55748 1571 2952 2678 2687 2950 2944 10 9 8714 9429 10057 6783 54658 10257 4363 6818 6817 1244 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 96%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) 1718 1717 6309 10682 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation 64432 65003 64951 65005 65008 28977 90480 51081 6150 55168 64949 28973 65080 51642 5018 54998 10573 11222 128308 51649 9553 64960 92259 63875 64963 64965 64968 55173 55052 64969 51373 26284 51650 60488 51253 51258 219927 29074 56945 64975 28998 64976 79590 64979 64978 23107 28957 64928 7818 57129 51263 29088 51021 54534 51023 51264 51069 84545 78988 122704 65993 64981 10240 64983 3396 26589 63931 6182 54460 6183 118487 51073 116540 740 124995 54148 116541 55037 29093 9801 51116 10884 54948 51318 123263 4528 219402 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins 6342 51 8540 3295 30 5264 219743 LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%5653890 Lactose synthesis 2683 3906 6513 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 96%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 2648 4851 22938 84441 10046 390874 6928 3280 2033 1387 50674 8850 3516 3175 9794 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 96%111931 PKA-mediated phosphorylation of CREB 808 107 5567 108 109 5568 5575 5566 5573 111 112 113 5577 114 115 5613 5576 26960 196883 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717319 brigatinib-resistant ALK mutants 238 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis 55330 54885 152503 26258 8907 8775 2804 130340 3482 84062 9698 10053 1176 1174 64746 8905 23557 162 164 10618 408 6456 4952 2512 2495 8673 2647 8546 375 6844 3312 10717 6845 7037 23431 81567 8301 1785 9829 5878 5286 51429 2580 1362 25977 9026 9685 7164 388552 7163 6272 286451 6643 27131 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963676 Intestinal absorption 6523 6248 6514 6518 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%352230 Amino acid transport across the plasma membrane 8501 153201 6520 6541 123096 81539 8140 23657 55117 56301 11254 6539 11136 6519 124935 54407 23428 92745 6533 6510 206358 84889 120103 6509 55089 117247 340024 10991 54716 9056 9057 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B 2677 2160 2159 2158 2157 2812 2815 2811 2814 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-HSA-606279.3 Deposition of new CENPA-containing nucleosomes at the centromere 8331 80152 8607 8337 2491 8334 8335 8341 8342 8347 55320 8348 8345 201254 51773 64946 55355 11339 8340 387103 54069 55839 8338 85236 8349 4869 8370 3013 1060 255626 55166 1058 79019 3018 3017 3014 23421 474382 5931 57082 8970 128312 94239 55766 64105 401541 8467 378708 79172 54145 91687 5928 79682 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME%R-HSA-5632927.2 Defective Mismatch Repair Associated With MSH3 4436 4437 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%9661070 Defective translocation of RB1 mutants to the nucleus 5925 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME DATABASE ID RELEASE 96%6791461 RPIA deficiency: failed conversion of RU5P to R5P 22934 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%975163 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation 7314 10454 7099 929 7189 353376 257397 148022 23118 23643 6233 7316 6885 3656 7311 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5213460 RIPK1-mediated regulated necrosis 355 10211 10015 7332 8743 5071 83737 841 3320 356 8737 329 11035 2319 8795 7186 8473 10273 8797 57162 7311 330 331 7314 6386 8717 197259 6233 7316 11140 8772 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72163 pre-mRNA splicing 22938 57794 22826 22827 10262 54883 11325 10236 55749 23658 25804 27258 23524 10450 51690 57703 10465 11157 53938 57819 11193 24148 24144 8899 23020 55100 85313 143884 9879 9410 23398 3550 9092 9416 55234 10181 8559 58509 51340 6936 59286 5093 79576 5094 51691 51593 6434 151903 57461 10713 84844 55702 1655 5411 22916 153527 60625 27238 3183 84811 11017 4686 8175 84950 9128 9129 51729 26017 7737 63932 9130 4236 79706 84081 25949 51503 27316 79171 55696 1659 10992 55094 79165 26121 5725 163859 10523 10284 79753 7536 4670 51747 51634 51759 988 6627 6629 220988 23450 23451 56949 5546 6638 10594 5356 3178 3181 3188 3187 3185 3184 9716 3191 3190 51639 8896 3312 51645 10084 10179 10291 8449 10283 8241 23350 10286 10285 9343 56259 10946 10907 9360 27339 1665 84991 2521 83443 22985 3192 4904 91603 1660 51428 9584 6631 10929 10772 6625 6626 135295 9785 10915 58517 6430 6432 27336 6431 55660 5511 10250 22794 51362 7919 199746 6427 6426 5440 6429 5441 9939 6428 10189 65109 23759 2963 2962 8683 5434 5435 9775 5436 5437 9295 5438 10921 5439 10569 11338 55110 5430 5431 4116 5432 7307 5433 4809 6632 6628 6634 6633 23517 6636 6635 6637 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 96%163125 Post-translational modification: synthesis of GPI-anchored proteins 4978 22854 503542 284348 154064 27076 2350 128869 390243 8875 7512 8876 266727 5329 1043 353091 80328 137797 248 135228 1048 338328 55650 51299 6975 146183 8813 54872 8818 23627 10026 161357 1087 4045 419 116372 4062 23556 420 349667 8733 10232 8434 284098 4241 54344 683 4061 171169 80740 54965 349633 94005 51227 53942 8000 152330 54742 5277 5279 123904 84720 249 5283 130576 251 10942 5281 147719 5067 83639 93183 8581 7007 51604 360226 84992 2813 2822 80235 9487 9488 146760 7070 50863 84628 646627 80055 257194 1368 2215 58530 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 96%9726840 SHOC2 M1731 mutant abolishes MRAS complex function 5500 7529 5894 22808 8036 369 5501 673 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus 10460 4904 1956 11060 4854 1950 7311 7314 9148 28514 182 54492 57534 102 54567 5663 142678 3714 5664 55851 83464 23385 51107 6233 7316 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism 283927 55289 54677 390916 26063 1962 122970 215 11001 3295 30 10005 51179 8310 55825 8309 91452 10478 5264 79777 1384 26061 23600 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 96%9757110 Prednisone ADME 7364 7367 213 1645 54659 3291 1576 3290 5243 866 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 96%3560796 Defective PAPSS2 causes SEMD-PA 9060 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013424 RHOV GTPase cycle 84612 8826 5062 79598 79834 10298 81839 9352 28964 8874 6709 8440 94134 1213 11180 55789 171177 9738 57630 6711 8239 50855 5295 56924 4690 7170 4649 5058 9231 7171 1969 667 4296 57473 9815 998 8976 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs 8331 3013 8337 5434 8334 5435 5436 8335 5437 255626 5438 5439 5430 27161 5431 8341 5432 3021 5433 3018 8342 3017 8347 3014 8348 8345 26523 8340 474382 8970 128312 8338 27327 85236 8349 94239 55766 8968 5901 653604 8370 5440 5441 54145 10526 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717326 crizotinib-resistant ALK mutants 238 NEPHRIN FAMILY INTERACTIONS%REACTOME%R-HSA-373753.5 Nephrin family interactions 8440 8826 23607 9863 6711 81 89 4868 88 55243 5295 4690 5296 8573 5290 84623 5291 84063 87 2534 8976 6709 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.7 Choline catabolism 501 23446 6583 55349 29958 1757 635 57153 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 96%5362798 Release of Hh-Np from the secreting cell 3549 147111 85455 6868 57758 6469 2262 50846 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 96%72689 Formation of a pool of free 40S subunits 6230 6231 6234 9349 6235 6191 6193 6192 6194 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 8662 6135 8663 6134 8661 6137 8666 6136 8667 6232 8664 6128 8665 6129 27335 3646 6142 51386 6141 6144 8668 6143 8669 6146 10480 6147 1964 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 6222 6224 6181 6218 6217 7311 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-5649702.4 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 3980 5423 7515 252969 4968 79661 11284 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG 8694 11343 57104 347516 84649 80339 158835 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9024909 BDNF activates NTRK2 (TRKB) signaling 627 4915 FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 96%217271 FMO oxidises nucleophiles 2326 2328 2327 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 96%937039 IRAK1 recruits IKK complex 1147 3551 57161 7334 8517 7335 246330 7189 3654 57162 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling 4734 7314 11059 6233 6714 7316 83737 7311 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 96%9703648 Signaling by FLT3 ITD and TKD mutants 4893 6654 3265 5781 50507 5295 2885 6777 6776 5292 5290 1026 2322 9846 598 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-HSA-110329.4 Cleavage of the damaged pyrimidine 8331 3013 8337 8334 8335 255626 8341 3018 8342 3017 8347 26277 3014 8348 8345 25913 8340 474382 8970 128312 8338 85236 8349 94239 55766 54386 8370 8290 8930 55247 54145 23583 7013 252969 65057 4968 7014 79661 6996 4913 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%428157 Sphingolipid metabolism 2524 2523 112937 6609 3074 3073 79411 2720 411 89944 9217 221 4363 8560 1455 2717 6483 6487 2760 30815 94103 84002 29906 81849 285362 79642 5476 25870 10825 340075 410 412 414 91012 415 23683 25865 416 80777 8869 5660 142891 340485 9334 53947 9331 9514 22901 29956 6610 153642 55331 388931 55512 347527 166929 165679 125981 79152 9517 4758 9218 55627 8706 4759 7357 9429 2583 204219 2581 253782 2629 171546 29095 56848 8611 8612 7368 5587 339221 57704 130367 123099 4074 259230 124976 56624 79603 8613 94101 10558 55304 10715 151742 64781 81537 57733 222 8705 2531 8879 5007 427 8877 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) 3423 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME%R-HSA-5083625.4 Defective GALNT3 causes HFTC 10071 94025 2591 143662 118430 140453 4588 4589 283463 4582 4583 394263 4584 4585 4586 200958 727897 56667 METABOLISM OF STEROIDS%REACTOME%R-HSA-8957322.4 Metabolism of steroids 6555 6554 200931 123264 10998 80765 3293 1582 6770 147323 83930 10948 26119 706 134429 3972 23600 8029 11001 3295 10005 10858 1594 1584 51302 570 213 8309 2172 403313 1718 6307 50814 39 64801 10682 51478 8644 91734 5443 96764 1589 3837 1585 3284 231 6907 3283 80205 8648 1081 10499 10498 79718 6604 1591 5641 5901 1387 23054 5469 85441 8714 114876 2194 79644 3291 3290 866 412 6256 7421 5465 2638 3930 8647 51588 120227 7329 10599 6613 1586 6715 6716 6720 1588 28234 112812 3638 2232 51360 2230 2224 2222 3157 6667 5007 26031 51128 9885 4800 9023 4801 1583 4802 3294 6309 51171 10654 51170 9871 441282 9632 114880 57678 9971 114881 10427 9420 114883 1593 6713 1581 6319 1646 22937 4597 6718 1645 79071 51141 80270 1109 1595 6721 9256 1717 31 32 9453 6579 4047 4520 8720 10802 3422 4598 10484 7108 4036 3292 51144 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%446652 Interleukin-1 family signaling 3557 240 27177 4088 3553 7850 8808 834 4215 90865 841 26525 3606 7186 8767 4615 4791 57162 79792 84639 84166 10454 9173 7334 6285 7335 3552 6288 11274 7189 64127 6283 3146 257397 5781 51135 23118 9683 9684 10392 5780 28512 79155 5771 5783 57161 5784 79671 177 26469 121457 25930 84867 246330 26095 8809 28511 59307 3656 5777 9097 27178 10068 5778 11213 5604 6774 5775 1511 9861 8454 6233 7316 1326 10213 6885 5706 23291 80216 92610 5707 5708 5709 1147 5700 5701 5702 5704 3554 5705 4790 5682 5683 351 4792 5684 4793 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 3654 5690 5691 5692 5693 5694 7311 5970 5695 9978 7314 6500 3551 5687 5688 8517 5689 5608 3565 3596 8807 6416 5782 11141 8878 5599 29110 7157 54472 56300 27179 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 96%9634635 Estrogen-stimulated signaling through PRKCZ 5170 5594 4893 5590 3265 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-HSA-191650.4 Regulation of gap junction activity 7082 2697 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 96%9830674 Formation of the ureteric bud 6299 9353 2296 2668 10736 2303 652 3237 5076 7481 3207 255743 2138 3227 6092 2674 3688 26585 8516 5979 6495 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity 5329 710 3818 708 3848 2161 2 3827 3273 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors 10848 54971 7157 7159 8626 25946 51230 207 208 7161 23368 5457 5458 10000 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 96%157858 Gap junction trafficking and regulation 1601 1212 4646 127534 219770 125111 375519 2702 57369 2701 10052 2700 1759 2709 1785 84694 2707 2703 10804 57165 81025 1213 1211 2697 2706 7082 8218 2705 1173 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK 57580 10276 9138 11214 128272 26230 121512 29 5924 84904 100271715 10018 25791 89846 54848 26084 22899 50649 8874 8997 64857 6453 7984 57449 389337 445328 2245 221472 55701 9500 10672 23263 9459 5879 4168 6654 27237 4803 4804 5599 7074 26574 572 55160 7410 23365 23370 9181 7409 1894 10451 9826 7204 9828 6655 23229 50650 9639 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 96%3359474 Defective MMACHC causes MAHCC 25974 GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking 1601 1212 4646 127534 219770 125111 375519 2702 57369 2701 10052 2700 1759 2709 1785 84694 2707 2703 10804 57165 81025 1213 1211 2697 2706 8218 2705 1173 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 6222 22916 6224 6181 6218 6217 4686 6230 6231 6234 9349 6235 6191 6193 7311 6192 6194 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 1981 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 23708 6203 6169 5976 6202 116832 6160 6161 2107 26986 6175 9045 2935 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 96%9686114 Activation of inflammatory caspases 808 3553 836 3606 837 838 1992 79792 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 96%190236 Signaling by FGFR 23767 22916 4686 161742 200734 5515 5516 5518 5725 4670 3730 7311 7314 867 4893 6654 3265 5781 673 5440 5594 5441 5595 7049 3178 10818 10755 3187 3185 2963 2962 5434 2591 5435 5436 5437 5438 5439 23768 5430 23769 5431 54845 5432 5433 10817 5335 2549 10253 8569 53834 9965 2254 9982 2252 143282 2251 27006 83888 8074 5295 2249 2248 2247 2246 5290 152831 23543 8823 80004 6233 7073 7316 2264 7072 2255 8817 26281 DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 5624 2153 5627 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%182218 Nef Mediated CD8 Down-regulation 51606 160 926 161 163 1175 1173 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion 1729 634 2766 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 96%204174 Regulation of pyruvate dehydrogenase (PDH) complex 1737 1738 5162 5163 5164 54704 5165 5166 2954 23409 8050 5160 5161 57546 55066 CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway 808 817 818 107 5567 108 109 5568 84254 5566 111 112 5580 113 3838 114 156 115 5137 5153 5136 26960 5578 5575 10645 5573 5582 5577 814 5613 5576 196883 815 816 SIGNALING BY RAS GAP MUTANTS%REACTOME%R-HSA-9753510.2 Signaling by RAS GAP mutants 3845 4893 3265 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 96%381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 2864 1499 5122 346562 28972 60559 5080 2782 2922 1045 338557 9789 139760 2784 1803 2641 90701 23478 51764 6934 3952 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease 4067 3815 4893 6654 6772 7525 3265 6774 5295 5296 6777 6776 8503 5290 3932 3717 2534 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 96%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 55971 8331 70 2017 10395 23092 143872 8337 10276 5099 347902 8334 9138 4810 55619 388 10787 8335 128239 85360 1729 8936 11214 5062 5881 128272 10152 26230 2185 29 121512 84904 64411 286205 124056 29127 8341 25791 613 89846 8342 51347 26050 8347 22899 3071 8348 8345 10163 50649 5364 28964 22865 8874 64857 653361 8340 23075 57449 116984 27035 23081 55114 354 2245 3817 4952 10006 221472 8338 55701 10672 9459 85236 389 8349 58480 5879 708 4771 54763 30851 9055 55200 399693 253959 23616 115703 139818 201176 57514 57636 6510 55219 55227 8370 26092 124997 58504 1072 1124 1123 10409 91452 114793 57679 998 114885 57569 27145 92799 57572 3013 10602 752 55968 51133 55852 255626 10144 64333 10093 116985 10092 25963 10095 79834 9912 10094 101059918 79822 10097 3021 23526 10096 3018 54438 1855 3017 157285 3014 29062 9938 10810 23779 3932 51291 9824 56990 474382 10435 83478 1857 84681 1856 7454 120 8970 7456 84317 128312 9644 23268 51306 147179 9411 94134 55766 393 399 11180 51566 8968 5361 84364 94240 171177 1362 7532 148170 22852 23348 89839 2886 27289 23580 222584 84144 55704 2802 65992 22800 8502 7409 10160 653604 11075 25894 91544 7415 55831 644150 51479 9231 57579 8503 54509 57216 26999 55717 224 10928 667 1730 9528 93663 9928 26049 1495 10963 9590 57473 123720 10109 80115 8976 158747 1445 4627 57120 8153 57480 117289 695 84986 10552 23129 343578 50619 157769 221178 257106 153478 114822 29984 51517 11060 445582 152273 79180 80243 23074 23197 10134 2697 908 10574 10376 10576 60 6722 23048 91010 57381 54874 2631 144402 8476 81704 9497 9578 23513 23229 64130 4628 79784 8086 3984 3985 5924 80179 55669 66008 89941 5910 9927 85440 57591 1213 23380 57522 9901 80728 29843 5783 3320 79658 22906 5578 9738 5579 10398 2810 10250 7919 3930 367 5338 84612 9855 79598 5590 387 23370 50855 54514 1080 200894 6472 7444 7204 9743 4660 2909 391 94274 4659 57584 392 9341 394 22836 57580 396 26030 397 398 80005 7879 5337 4722 10298 10652 3954 3998 9710 51209 81839 10788 26084 26286 4698 3688 8997 6453 7984 5347 2010 9146 23344 143098 8027 63916 3336 23141 9367 23263 5825 1794 1499 1793 4983 3895 999 8987 55789 10254 4162 6714 7112 9217 4168 6654 9732 27237 23191 81624 23592 2889 11135 6811 55240 5880 1969 1432 55914 6279 6280 5594 5595 7534 10971 7533 10818 57498 5600 7529 55075 5500 10226 55288 2316 5747 5300 7514 27 10499 8440 857 4650 7410 4221 51466 56924 4690 10451 10424 23028 6655 11140 6434 9886 8654 57144 808 23221 5216 29766 5217 6093 3183 55023 11329 56254 5930 4001 71 7531 9318 5756 4646 7431 9475 124540 23013 27316 9352 3326 995 2873 79869 51138 1627 87 6709 4629 6711 55004 7170 7171 103910 4637 4638 56667 4548 5289 25 30849 1742 8452 9462 10211 2319 57630 8239 898 832 1027 54908 6232 8655 25909 3798 3799 8379 9183 1063 1062 9184 4580 1060 991 151648 25813 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 348995 348235 5580 5048 23421 57122 220134 57082 57405 147841 51143 6249 55746 4085 64105 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 1781 23122 1780 79172 8776 1778 81930 55920 84643 3796 4296 9793 91687 7535 57551 79682 5905 64837 1783 5501 147700 83540 80152 5903 2491 8826 5519 332 55143 699 3831 11243 140735 3619 5515 89953 11004 5516 5518 9212 25936 11130 64946 79980 10726 79902 5525 5526 55839 5527 5528 5529 23256 3163 1832 9414 10489 1829 1828 537 7037 7074 1795 7428 10817 8301 94239 50618 6793 182 65124 5585 5586 55160 1629 23002 23365 115557 7126 9181 390 29941 11188 10970 85415 5295 1152 5296 1894 4649 10505 5058 253980 8773 6242 9754 5290 50508 2040 5170 395 1536 3728 54443 9322 10811 54145 9748 1535 10458 9826 55843 11113 10979 90627 64283 9815 4688 9828 284119 55845 4689 50650 9639 5063 9235 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9632700 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 1029 1021 1019 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis 1588 3294 3292 51171 51170 441282 CHD CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9937848 CHD chromatin remodelers 8331 8337 8334 1107 8335 8313 53615 11335 8341 8342 8347 8348 8345 1108 8340 23168 79577 80349 8338 85236 1499 8349 123169 9646 3066 54623 8370 57504 9112 3013 3065 7182 255626 3021 3018 2033 3017 22827 3014 27123 3481 10262 474382 80205 57459 11325 8970 128312 54815 7975 22850 55766 23394 8968 57680 10664 1728 4780 653604 84181 2203 1387 9879 11091 2538 1105 5928 84844 6925 8175 6749 4654 4656 11198 10992 6929 10523 9219 10951 6627 6629 23450 23451 6938 6638 7341 114825 125997 85409 170394 79843 85509 55636 5105 8099 26038 55205 7329 6941 22806 22807 57592 23613 10263 8932 9640 7026 10320 51639 152485 84295 10291 5931 94239 23350 10285 1106 10946 6632 6628 1665 84991 6634 6633 83443 6636 6635 54145 6637 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 96%380284 Loss of proteins required for interphase microtubule organization from the centrosome 11116 7531 54930 5566 79959 5518 93323 983 22981 5347 80254 55755 10806 10121 9662 55835 10733 80321 55125 9814 115106 8655 79441 9702 5108 55142 10383 22897 10382 10142 5116 23332 80184 3320 22919 7846 5048 23354 8481 7840 11064 121441 22994 22995 7283 7277 55559 203068 1454 8636 55722 4751 11258 1453 7532 54820 84131 9738 11190 4957 1781 95681 1778 1069 5577 9793 54801 10540 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion 9630 2769 5330 1131 5331 4082 23236 2767 2776 5578 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013700.2 NOTCH4 Activation and Transmission of Signal to the Nucleus 23385 51107 182 4855 102 7534 54567 5663 5664 55851 83464 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 96%3595174 Defective CHST14 causes EDS, musculocontractural type 633 1464 1462 1463 10675 63827 1634 113189 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013418 RHOBTB2 GTPase cycle 8452 23221 29766 3183 55023 11329 71 10250 5756 908 4646 124540 7919 27316 3320 9352 3326 10574 1627 87 10576 11140 6434 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 96%9764561 Regulation of CDH1 Function 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 27085 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 2060 79872 7311 1500 1499 5695 54971 7314 999 5687 4193 5688 6714 5689 1514 10399 1785 1520 1508 9861 3728 6233 7316 1495 10213 5706 7414 5707 VPU MEDIATED DEGRADATION OF CD4%REACTOME%R-HSA-180534.3 Vpu mediated degradation of CD4 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 6500 920 5687 5688 5689 9861 6233 7316 10213 5706 5707 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence 1029 1021 1019 NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 96%8956321 Nucleotide salvage 161823 4860 8226 270 271 272 51292 7371 7083 132 83549 3251 100 54963 353 2766 1633 1716 978 7378 151531 1890 7084 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer 4087 4088 7046 7048 7040 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport 51228 83850 84725 1201 57488 375 23344 80772 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME%R-HSA-5619085.4 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) 1811 ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 96%5662853 Essential pentosuria 51181 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1483249 Inositol phosphate metabolism 808 23636 5903 9972 9631 7175 11097 9108 23511 8086 8021 53371 8480 66036 10762 55586 3613 79902 3612 23007 51477 27124 3632 8867 4952 3628 3633 3635 3636 9651 5332 170685 5333 23262 113026 11163 84812 9677 3705 11165 5728 3706 64768 51196 55190 3707 89869 9807 117283 122618 80271 348995 5335 57122 55746 51447 5330 23279 5331 79023 253430 9562 23236 6396 9883 129401 9688 5336 23225 4927 3631 23165 8821 55706 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders 23636 5903 9972 9631 7175 11097 2646 23511 8086 8021 53371 8480 10762 56606 79902 60482 55343 9187 10559 551 6523 1836 4891 552 6514 553 554 6531 23443 30061 6584 26503 5002 246213 9197 340024 116085 6505 8671 54716 6530 6507 123041 9843 10999 9056 6524 10599 153201 7355 6520 5172 55630 1811 1356 6513 6566 9152 682 6575 11254 28234 81031 11136 6519 55315 10568 283652 6569 6578 142680 348995 57122 6557 6559 2645 9990 6005 55746 6521 10479 3098 285195 23279 6528 79023 6396 9883 129401 9688 23225 4927 23165 55706 TICAM1 DEFICIENCY - HSE%REACTOME%R-HSA-5602566.3 TICAM1 deficiency - HSE 7098 148022 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 96%3371571 HSF1-dependent transactivation 84335 817 818 3304 10728 3312 3281 26353 3320 2033 1410 1387 3297 3326 3306 64223 3305 3337 57521 2288 2475 815 816 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 4804 3065 4803 11108 3066 8841 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 96%189445 Porphyrin metabolism 10599 28234 3162 3163 644 645 213 7389 5498 1352 3145 7390 1371 9429 210 211 212 2938 54658 2235 1355 54657 4363 2168 1244 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism 6833 2182 2181 11069 10411 6514 776 5906 948 5567 5568 5563 5565 111 112 1131 113 114 115 5578 2864 3710 5330 5331 23236 5575 5573 5577 3767 26251 5576 9495 3790 196883 2771 2770 8826 5519 3630 107 108 10768 109 3708 3709 5566 5515 5516 5518 2194 5528 3745 3747 2793 2792 2791 6794 2790 2788 2787 2786 2785 2784 2740 2783 51764 94235 6812 10554 9630 55970 6513 6844 775 6616 6804 6888 54331 59345 51085 2642 79602 2641 9370 51094 2767 5207 2769 4082 150 773 7086 152 777 6945 6861 31 51422 32 9254 2776 783 784 2782 47 2778 10681 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors 56656 120065 121275 120066 283365 390883 390882 390649 390648 124538 283111 4991 4992 4993 442184 442185 442186 79310 79317 284433 341799 219954 219952 121130 79541 79544 121364 125963 125962 4994 79549 4995 283694 121129 219965 130075 219960 390431 390433 442361 390436 390437 390439 341418 79334 341416 79339 219959 219958 219957 219956 283162 138804 65055 138805 283160 138802 138803 390441 390442 390321 390201 390323 390445 390326 390327 144124 254973 144125 79324 283159 219968 127608 219865 219986 219983 219982 390892 219981 401994 401993 401992 285659 81309 79473 81797 390538 7932 219858 219875 219874 219873 219870 390429 79346 79345 26188 81300 26189 219869 347168 26716 286365 283093 283092 347169 138799 390113 134083 391211 392309 150681 338674 338675 340980 283189 219417 219438 219437 219436 26707 219432 219431 126541 338662 403282 403284 127623 254879 283297 255725 219429 284383 219428 126370 219447 390271 390151 390152 391121 441308 390154 390275 390155 441669 390157 390036 390037 390038 441670 158131 138882 138883 138881 23538 390162 219453 390167 390168 347468 219469 219464 338751 391107 391109 338755 254786 254783 10798 390260 390261 219479 390142 219477 162998 390264 391112 390144 390265 391114 219473 390148 79501 286362 390072 390195 390075 390197 390077 219487 390199 392376 390078 390079 219484 219482 392138 127385 143502 119764 119765 143503 81050 390081 390082 390083 390084 26687 119749 402135 26689 219493 81168 81285 392391 81282 392390 504190 1879 390174 390054 26533 256892 390058 26532 390059 26534 26658 26539 26538 26659 26531 343173 390181 390061 343172 343171 343170 390063 441639 390064 389090 390066 390067 26664 343169 81061 390190 390191 403274 127062 403277 403278 127069 127068 127066 127064 403273 120787 119687 81099 119682 26529 441933 127059 26648 120775 120776 119678 9355 119679 390093 392392 403253 441608 403257 391189 26735 128371 26737 8590 128372 391190 196335 391192 346525 391191 391194 391196 391195 403244 128366 128367 128368 128360 119774 119772 26740 403239 346517 79490 81328 120586 256148 81696 81697 8387 8388 8386 8383 81318 79482 81448 81327 81442 132112 393046 8861 8390 8392 122742 26494 401427 26493 26496 401667 401666 282775 122740 401665 26497 81470 81472 282770 341276 122748 127074 341152 256144 127077 283617 120796 81469 119694 119695 120793 81466 282763 81341 343563 119692 387748 344892 79290 79296 135924 79295 26595 26476 284532 125958 442191 26246 442194 26248 442197 81127 26245 284521 135941 26339 26338 135946 26219 135948 26692 402317 26693 26333 26696 26212 81399 26211 81392 388761 343406 26341 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C 138050 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-HSA-5654732.3 Negative regulation of FGFR3 signaling 7314 867 2254 5515 5781 5516 8074 673 5518 2249 2247 2246 8823 5594 6233 5595 7316 10253 8569 10818 8817 26281 7311 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-HSA-110357.3 Displacement of DNA glycosylase by APEX1 4350 8930 328 23583 4968 6996 4913 DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 96%9675135 Diseases of DNA repair 5888 80010 5889 7979 5395 4436 4437 4292 2956 7486 5982 5983 3364 472 672 675 84126 144715 83990 5810 7516 5932 9156 11073 641 6117 5984 5985 6119 79728 6118 5883 5884 116028 10635 83695 10111 4361 7156 55247 5890 5892 4683 4968 580 79661 10524 4913 1763 545 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%561048 Organic anion transport by SLC22 transporters 9356 55867 116085 9376 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 96%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) 28234 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 96%909733 Interferon alpha beta signaling 10581 3105 4938 7297 3665 2634 6773 4940 25939 8651 2537 103 8638 8519 3454 6059 3660 3107 3106 7311 5696 7314 3134 3133 11274 3663 5781 3135 9021 5777 9636 3442 3441 3440 3456 24138 3452 3662 3451 6772 3449 4600 3448 10410 3446 3445 3444 5770 3443 91543 3837 3430 5610 3661 3664 3669 3429 3437 3716 3434 3433 51447 6041 684 1958 54739 3659 10379 4939 6233 7316 3836 3394 4599 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 79661 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME%R-HSA-5624138.4 Trafficking of myristoylated proteins to the cilium 192668 6102 84747 403 27031 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes 5644 8029 6947 1504 5646 5826 55788 81693 2694 440387 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%6784531 tRNA processing in the nucleus 23636 5903 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 79902 10978 10898 1478 79897 54913 29894 51095 348995 11102 57122 55746 23279 79023 6396 11260 1653 5901 51367 10775 80746 10799 79042 10557 51493 10940 9883 339487 129401 79074 10556 9688 283989 283742 116461 60528 10248 23225 51637 4927 23165 55706 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation 1147 3551 57161 7334 8517 7335 246330 7189 3654 57162 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) 55630 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 96%5654228 Phospholipase C-mediated cascade; FGFR4 9965 2254 2251 8074 2249 2247 2246 152831 5335 8823 2264 8817 26281 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) 6520 9056 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%450302 activated TAK1 mediates p38 MAPK activation 7867 10454 7334 8517 7335 7189 64127 5608 257397 9261 23118 1432 10392 5606 3654 6885 3656 8767 5600 TCR SIGNALING%REACTOME DATABASE ID RELEASE 96%202403 TCR signaling 7321 5062 50852 5788 5795 8767 7322 997 5728 7334 7335 5588 7189 23118 3123 3122 3120 3119 3118 3115 3113 3127 3126 3125 3932 7454 51466 4690 9861 55740 8454 5336 6233 7316 3937 7535 10892 27040 10213 9398 6885 1445 2533 5706 3702 23291 5707 5708 5709 1147 84433 7408 5700 5701 5702 5704 5705 4790 5682 5683 4792 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 3635 5693 5694 7311 5970 5695 7314 6500 3551 5687 5688 8517 5689 8915 55824 5335 915 916 917 920 9402 5295 5296 5058 5290 5170 5291 26191 5063 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371599 Defective HLCS causes multiple carboxylase deficiency 5095 64087 56922 31 5096 3141 5091 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 96%176409 APC C:Cdc20 mediated degradation of mitotic proteins 5708 5709 5700 51529 5701 7321 5702 5704 8881 64682 5705 25906 11065 5682 8697 5683 7324 5684 10393 29945 27338 5685 119504 5686 29882 5717 891 5718 246184 5719 983 996 11047 51434 5713 51433 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 890 5687 5688 5689 9184 991 8900 4085 4751 701 9861 9232 6233 7316 10213 5706 5707 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-HSA-1660662.8 Glycosphingolipid metabolism 2524 2523 29906 81849 285362 79642 5476 112937 25870 6609 3074 3073 10825 79411 340075 2720 411 410 412 89944 414 415 416 8869 5660 9334 53947 9331 9514 22901 6610 153642 55512 347527 4758 55627 8706 4759 7357 2583 2581 2629 7368 339221 57704 4074 56624 64781 57733 8705 2717 6483 6487 427 2760 30815 84002 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 96%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome 10166 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 96%9945266 Differentiation of T cells 3566 1107 2353 79885 861 6778 53615 8535 4853 4094 8850 1108 9219 9794 8459 3725 648 83933 4851 6015 6304 1912 1911 3066 5452 10046 3565 80012 3596 84733 9612 6045 51621 57504 6597 7528 9759 2625 9112 22938 2113 3065 84441 23466 3662 57332 6348 9734 2033 3458 4297 6907 57459 5931 54815 6775 2648 864 9070 79718 3595 4221 51564 8841 10013 3567 9611 6777 10014 1387 84661 6776 11091 3516 10538 5928 4772 5929 4773 30009 55869 5451 7124 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage 1633 978 7378 151531 1890 8226 7084 7371 83549 7083 54963 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME%R-HSA-167290.4 Pausing and recovery of HIV elongation 2963 2962 5434 5435 5436 5437 6827 5438 6749 5439 5430 5431 5432 9150 5433 6917 1025 51497 11198 8812 25920 51224 6921 6924 7936 6923 7469 904 905 5440 5441 6829 8178 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 96%114294 Activation, translocation and oligomerization of BAX 581 637 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME DATABASE ID RELEASE 96%9846298 Defective binding of VWF variant to GPIb:IX:V 7450 2812 2815 2811 2814 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin 1956 4893 6654 3265 5578 4314 1839 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-HSA-6807878.2 COPI-mediated anterograde transport 55860 51164 10671 8774 8775 2804 26958 3630 93661 22796 84516 9382 378 140735 10652 51014 23423 2801 5861 25839 51272 22818 26286 2348 22820 377 10972 83548 63908 57511 64689 10466 6708 6709 10121 286 1639 287 84342 288 8615 91949 966 51332 6711 6710 6712 372 81876 830 10959 381 6811 832 11316 9527 10282 11015 9570 8729 829 54732 8655 51226 11070 57731 375 11014 55738 51143 9276 84364 1315 4905 11258 1314 10945 1781 1780 1778 10540 1783 1604 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 96%4086400 PCP CE pathway 5708 5216 5709 5700 5701 5702 5704 5705 5881 5682 5683 5684 409 64750 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 5879 7314 1213 1211 5687 160 5688 161 5689 163 7481 5880 4919 4920 1175 1173 81029 54361 1212 1855 1857 7855 1856 7976 8321 6259 5578 8322 57154 7474 8325 23002 387 8323 8324 50855 5582 7471 57216 9861 23513 2535 6233 7316 5579 10213 144165 5706 5707 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME%R-HSA-4755579.4 Defective SRD5A3 causes CDG-1q and KHRZ 79644 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase 23704 9992 3784 27092 23630 3753 59285 775 9254 10142 782 783 59284 59283 10008 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat 2963 22916 2962 2068 5434 5435 4686 5436 5437 6827 5438 6749 5439 2968 2967 404672 5430 5431 5432 9150 5433 6917 1025 902 51497 11198 25920 51224 6921 6924 7936 6923 7469 904 5440 5441 4331 1022 2071 6829 8178 2966 2965 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%450341 Activation of the AP-1 family of transcription factors 5601 1432 5602 1386 5594 2353 5595 5599 3725 5600 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855196 IP3 and IP4 transport between cytosol and nucleus 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 10762 348995 79902 57122 55746 23279 79023 6396 9883 129401 9688 23225 4927 23165 55706 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) 9187 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 96%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) 10479 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-HSA-2187335.6 The retinoid cycle in cones (daylight vision) 9249 2652 5956 5949 6017 158835 611 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d 10195 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619229 Activation of RAC1 downstream of NMDARs 808 5879 8536 28964 84254 10645 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 96%1236978 Cross-presentation of soluble exogenous antigens (endosomes) 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5698 5718 5699 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 5696 5695 5720 5721 9902 5687 5688 2209 5689 50489 4360 9861 10213 5706 5707 HIV TRANSCRIPTION INITIATION%REACTOME%R-HSA-167161.4 HIV Transcription Initiation 6872 2963 2962 6874 2068 6873 5434 6908 5435 5436 5437 5438 5439 6881 2968 6880 2967 6883 404672 6882 5430 6884 5431 8148 5432 5433 902 6875 6878 83860 6877 2959 2958 6879 2957 54457 2961 2960 138474 5440 5441 4331 1022 2071 2966 129685 2965 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2468052 Establishment of Sister Chromatid Cohesion 23047 8243 113130 114799 10735 9126 23063 5885 157570 10274 23244 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation 55970 107 5567 108 109 5568 5566 111 54331 112 113 114 59345 2642 115 2641 2791 5575 2790 5573 2788 2787 2782 2786 2785 5577 2778 2784 5576 2783 51764 196883 94235 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%435354 Zinc transporters 7781 64924 7922 7780 55630 25800 283375 7779 23516 29986 57181 29985 169026 64116 27173 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia 54658 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 96%167238 Pausing and recovery of Tat-mediated HIV elongation 2963 2962 5434 5435 5436 5437 6827 5438 6749 5439 5430 5431 5432 9150 5433 6917 1025 51497 11198 25920 51224 6921 6924 7936 6923 7469 904 5440 5441 6829 8178 FLT3 SIGNALING IN DISEASE%REACTOME DATABASE ID RELEASE 96%9682385 FLT3 signaling in disease 2804 9321 598 7311 7314 867 399687 4893 6654 6711 3265 5781 50507 2120 2885 5295 6777 6776 5292 5290 1026 6233 7316 2323 2322 9846 7750 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 96%389359 CD28 dependent Vav1 pathway 5058 5879 3932 5062 940 941 2534 942 998 7409 5063 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events 122876 5032 2852 3688 3972 3973 6714 387129 9287 3363 3362 3360 153 1395 5443 154 155 4157 5567 5568 1816 83551 4161 1812 134864 319100 134860 57105 9038 111 112 113 4160 114 3274 115 156 4159 5153 7252 594857 5136 1081 2863 136 2869 346562 5575 5573 5577 5576 196883 2771 170589 2770 2781 5729 2773 107 108 109 5739 5732 5566 408 409 5734 2492 2488 5741 551 2793 2792 2791 2790 554 9340 2788 2787 796 2786 797 2785 151306 116 2784 2740 117 799 2783 51764 94235 3375 1394 3678 1392 55970 113091 79924 10266 5744 4158 5745 10268 5746 10267 2692 2691 133 54331 10888 59345 2642 2641 10846 50940 3640 8622 5141 5143 122042 5144 117579 135 5138 6019 5139 5151 7433 59350 6344 5150 5140 53831 7432 7253 11245 6343 11250 285601 2838 7434 2843 157 2848 2782 27115 2854 2850 2870 2778 2696 2695 10681 10203 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 96%5693607 Processing of DNA double-strand break ends 80010 8924 8341 8342 8347 8348 8345 8340 7311 85236 8349 7314 7336 890 7334 1017 8370 8290 51588 7329 6613 7486 255626 7468 29086 9025 5982 51548 5983 51720 3364 54962 8900 472 63967 151987 672 84142 165918 84126 7158 144715 3018 83990 3017 5531 5810 3014 9577 79184 5932 8914 9156 11073 6047 641 8970 128312 6117 5984 5985 6119 9656 6118 5883 5884 116028 1111 83695 10111 4361 7156 6233 54145 7316 4683 580 10524 1763 545 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades 114609 695 948 1147 6271 2243 4790 7097 7096 4792 23643 4791 4615 5970 81622 7098 3551 51284 7099 8517 929 7187 148022 3146 51135 7100 6279 6280 10333 81793 2244 2266 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 96%71291 Amino acid and derivative metabolism 26 8604 144193 10165 57571 85007 3067 3034 131669 3176 138199 10841 1384 1610 8528 54363 51520 27165 1615 5859 120103 51268 1892 4141 189 3376 196743 7965 9521 6583 6520 8140 162417 445 5917 435 1373 10166 3735 6539 5009 57407 9255 383 9061 9060 2058 7252 50506 53905 405753 51061 1081 7173 1734 1733 389434 857 3028 90527 6528 1735 2653 7166 440 57153 501 23446 55349 29958 1757 2593 5409 7054 1644 1621 4143 4552 191 4837 4548 7157 10249 6538 6534 2752 8424 7263 123688 25828 57515 58472 55217 100131187 65263 23743 125061 51380 29920 4507 2326 5831 8564 1036 262 875 169355 58478 384 6821 5723 635 275 84245 51686 2806 548596 2805 23498 23474 113451 339896 2875 1491 1160 51582 51074 55256 10955 1468 1158 6723 4357 10157 84890 347735 6611 79814 8942 6230 56267 6231 6999 6234 284716 38 9349 89874 6235 57494 6191 112817 2731 6193 83884 3081 6192 6535 6194 51151 6898 9380 3242 63826 4948 7299 2184 256987 51121 51166 7306 1638 6303 6227 55526 6229 2628 6228 619189 11224 2639 200916 1428 6122 130013 6124 29968 6123 4947 6125 4942 25873 4946 140801 26227 223 3921 3620 4736 4953 6130 6133 6132 6135 6134 6137 6136 64902 6232 6128 6129 6142 6141 6144 443 6143 2346 6146 339983 6147 10003 5053 374569 883 259307 6139 5860 6138 5092 6152 80150 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 2744 6201 6167 6203 6169 6202 116832 6160 6161 1728 6470 6175 9045 6210 6176 6171 6170 58510 6173 8659 51065 9861 5625 6205 6204 6233 6207 6206 6209 10213 6208 6188 5706 6187 6223 5707 6189 1743 4967 5708 6222 5709 64087 6224 152926 6181 26275 6218 5700 549 6217 5701 56922 5702 3712 5704 5705 5682 5683 5684 5685 5686 5717 5718 2954 5719 11047 5713 5714 7979 5690 5691 7296 5692 5693 5694 7311 5695 5687 92259 5688 5689 23408 2746 2747 5827 15 121278 438 113675 10993 10247 594 10295 1629 1738 593 9673 36 1152 586 587 27034 11112 4329 11185 118672 22928 51091 51540 6301 27232 60678 79048 RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription 864 4088 4089 2309 10018 SIGNALING BY WNT IN CANCER%REACTOME%R-HSA-4791275.5 Signaling by WNT in cancer 5519 139285 5515 27121 5516 324 79412 5518 83999 8658 80351 27123 8312 54894 7855 5525 5526 5527 5528 8322 5529 89780 1499 8325 1452 2932 4040 22943 4041 8323 1488 1487 64840 6934 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3311021 SMAD4 MH2 Domain Mutants in Cancer 4087 4088 4089 HCMV INFECTION%REACTOME DATABASE ID RELEASE 96%9609646 HCMV Infection 92421 8331 23636 9972 9631 8337 27243 7175 440689 8334 11097 128866 23511 8335 8086 8021 53371 8480 10762 8341 79643 8342 51652 8347 8348 8345 3688 8340 8338 85236 8349 29082 91782 25978 1616 8370 9612 2146 8655 3013 255626 3018 3017 1052 348995 6907 57122 8970 317772 51143 128312 92815 55746 85235 8969 221613 79718 23279 8726 79023 8968 6396 8841 1781 9611 653604 1780 1778 23512 5928 1783 51160 55048 89853 5903 11267 51028 155382 137492 27183 10155 93343 7251 1956 51271 4790 79720 140735 84313 79902 10951 2002 5119 3190 2874 5371 5931 9883 129401 9688 23225 4927 23165 55706 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660499 Synthesis of PIPs at the plasma membrane 65977 59339 59338 4534 55613 80230 66036 5287 5288 8394 8395 64419 27124 8867 4952 660 3635 3636 55300 8898 5728 8396 5783 146850 5867 375 5868 5286 51552 23533 23396 5305 5294 5295 5296 8897 8776 8503 9107 5290 55361 81846 8871 5291 22874 5293 84725 57664 54477 51763 3631 8821 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation 6872 6874 6873 80010 6908 6749 8445 6881 6880 8851 6883 1020 6882 6884 8148 9212 6790 11198 6875 6878 83860 6877 26155 53632 6879 22974 54457 7311 4194 8550 7314 890 4193 138474 6794 1017 11200 204851 1432 1263 5600 94241 7486 5982 5983 5562 3364 5563 8900 472 5564 672 5565 84126 144715 83990 5810 5932 28996 1460 5571 1459 9156 1457 11073 641 6117 5984 5300 5985 6119 9891 6118 7157 5883 5884 116028 51422 1111 83695 10111 112858 4361 7156 6233 7316 4683 580 10524 1763 129685 545 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling 127124 23545 51382 533 534 535 7018 537 10312 50617 7037 7036 3077 9296 245972 245973 155066 57192 9114 55240 51606 9550 79689 523 525 526 527 528 529 8992 90423 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols 5443 9915 1588 285440 112812 2232 1582 2230 57491 1589 196 1585 1583 8648 9971 9420 10499 1593 1581 1595 10858 1584 6256 51302 1545 405 G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 3065 1875 1874 8900 993 983 990 5111 4609 7027 890 1017 1859 898 7153 286826 4149 9134 132660 91750 7029 55957 1869 5928 5933 5934 4605 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 96%9006927 Signaling by Non-Receptor Tyrosine Kinases 2064 1956 5921 120892 10457 63916 7311 1793 5879 7314 867 9564 1019 595 4893 1017 3265 898 2034 6421 1398 1027 9844 10657 10656 5753 202559 2908 685 9021 27043 2069 1796 1839 116985 3084 6774 5770 9542 10718 145957 1950 6725 3091 5829 387 207 55620 6233 7316 2909 DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 96%5579004 Defective CYP26C1 causes FFDD4 340665 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME DATABASE ID RELEASE 96%9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 23189 2803 3791 2120 51411 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 96%901032 ER Quality Control Compartment (ERQC) 6400 11236 7314 84447 9695 11253 91445 6048 6233 55741 7316 80267 10299 10206 56886 267 7844 51009 7311 10956 55757 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%5663202 Diseases of signal transduction by growth factor receptors and second messengers 3587 192670 27161 613 4170 5155 26523 2475 50616 10956 1786 5879 5156 57690 2932 192669 79109 5663 3791 5664 81608 388585 5781 2120 55851 51411 83464 23385 51107 27248 26508 146850 5777 51009 471 4343 6400 55615 6772 6774 9061 3932 64223 10000 23533 7525 207 208 7409 7415 8503 2534 3586 1445 4627 22916 2804 4686 7297 2308 8658 80351 2100 1639 55733 80824 3674 3084 1024 6238 2260 4303 572 842 7157 1852 1850 11221 10013 10014 6199 892 7175 22808 8036 3280 7040 6194 1213 3066 2305 5551 29851 51530 9612 2323 1849 1848 1185 84441 27044 23164 8805 8546 3662 57670 10827 10142 54845 56829 9444 57085 3320 9715 11044 55109 4000 22906 8087 55750 2931 80853 8312 3092 57448 51564 5495 5573 53335 238 23493 27436 6801 9451 9861 8454 6233 7316 10213 5706 5707 5708 11116 5709 1147 23462 5700 5701 5702 5704 5705 1956 7039 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 7291 5695 7314 6500 5687 5688 5689 2099 9759 7750 9321 3726 9542 10718 145957 597 2648 1452 833 3516 2335 391 79885 891 4233 83933 1499 4869 5728 867 6714 4893 2803 6654 3265 9648 673 5880 55914 4140 5594 5595 6464 10818 5906 22938 7529 3065 5604 3815 5605 5500 2033 6907 2261 79718 84447 8841 9611 50507 2885 6777 1387 6776 5292 55869 11140 2280 808 23189 2064 10018 8850 2309 3725 4478 3164 4851 9978 7046 7048 6711 7170 7171 7249 685 6469 255324 2069 1839 5782 84335 8878 50846 324 9734 2263 7855 8322 89780 8325 399687 9965 11052 26127 2254 8323 1523 2252 2251 27006 8074 2249 2248 2247 3549 2246 152831 8823 8660 2264 2255 9846 3667 8817 26281 3002 4763 4087 4088 4089 399473 161742 200734 118788 5159 50852 4916 9794 10533 10046 1027 64840 1026 80304 5925 2322 3799 27121 79412 83999 27123 54894 57599 57674 6249 3845 4040 22943 4041 4296 7535 8315 5245 3717 2244 2266 815 5501 7414 9530 816 8844 817 10256 818 54518 5903 8826 22866 5519 7450 3690 5894 5037 139285 3831 2243 9208 7094 5908 369 283455 5515 408 5516 409 5518 22872 5525 5526 5527 5528 5529 4193 10342 5601 5440 5441 4008 2963 2962 5434 930 5435 5436 5437 5438 5439 5599 1051 5430 5431 5432 5433 4915 4908 8496 10817 4909 5335 627 2549 4609 374 1950 598 1937 4067 9148 28514 11160 182 54492 57534 102 3082 253260 54567 6868 142678 3714 5294 5295 1488 5296 1487 5290 5170 5291 5293 940 941 942 6934 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA 10642 10644 10643 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375281 Hormone ligand-binding receptors 170589 2798 2797 2796 2492 7252 7253 122876 3972 2488 3973 1081 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669926 Nilotinib-resistant KIT mutants 3815 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 96%6814848 Glycerophospholipid catabolism 10908 79153 51573 133121 284161 375775 81544 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription 3280 3002 2033 4853 2208 3516 84441 9794 10046 388585 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%169893 Prolonged ERK activation events 7529 5604 5605 2889 673 1399 1398 4803 5594 5595 10818 4914 5906 57498 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME%R-HSA-5619068.5 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) 81031 RHOC GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013106 RHOC GTPase cycle 9341 394 23092 10395 57580 6093 8826 396 9138 128239 10211 1729 11214 29 9475 3998 29127 613 81839 2319 7984 55701 23263 5825 389 4983 708 55789 4162 7112 80728 9217 4168 399693 81624 9414 6811 55219 55914 3930 91452 114793 7037 857 6793 4650 5585 5586 55160 7410 23002 387 23365 115557 91010 29941 5295 6242 2040 3728 93663 54443 9748 9826 11113 90627 9743 64283 2909 9828 284119 57584 392 9639 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function 5888 80010 5889 7486 472 672 675 83990 7516 5932 9156 7979 641 79728 116028 10635 10111 4361 7156 5890 5892 4683 580 10524 1763 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation 10256 54518 8826 22866 7529 7450 3690 5604 5894 5605 5037 2243 7094 54756 5908 369 84292 283455 408 409 6714 4893 3265 8649 673 4140 5594 5595 28956 2335 2244 1445 2266 5906 7414 3674 8844 MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206290 MPS IV - Morquio syndrome A 2588 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769743.1 Amplification and propagation of coagulation cascade 5624 7450 2157 2147 2811 2153 2160 5270 2159 5104 2158 196527 2812 5627 3053 2815 2814 462 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 96%9605310 Defective Base Excision Repair Associated with MUTYH DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 1950 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase 51529 7321 991 8881 64682 25906 11065 8697 7324 10393 29945 27338 51343 119504 29882 8556 246184 996 51434 51433 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family 7781 64924 169026 7780 7779 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation 23112 5728 26523 57690 192669 192670 27161 27327 4343 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 96%74749 Signal attenuation 3630 8660 5594 5595 2887 6464 6654 3643 3667 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 96%4549349 Defective ALG2 causes CDG-1i 85365 RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696270 RND2 GTPase cycle 394 23129 23074 7037 81839 27316 157285 9352 10817 10726 56667 3895 857 11180 55789 22852 222584 7126 23048 2802 11188 8502 23592 10970 5295 5296 91544 9231 1969 253980 1828 55227 57216 224 5783 667 23513 9928 10818 2909 8153 57498 392 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin 6777 6776 8660 3717 3667 5781 6774 9021 3952 ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-HSA-418990.6 Adherens junctions interactions 8331 8337 8334 8335 100128731 192670 27161 8341 8342 8347 8348 8345 50649 26523 8340 8338 51129 2060 79872 85236 1500 1499 8349 1793 5879 6185 999 23112 6184 6714 57690 192669 746 1603 6591 26508 8370 9844 5594 5595 2146 998 4343 3013 3065 255626 6774 3021 3018 6663 3017 7841 3014 474382 90701 3703 8970 128312 27327 3716 55766 1650 8726 8968 23193 7410 28972 5589 23411 653604 2294 56978 8728 64403 23512 1495 27319 5928 23028 23478 80332 1006 3224 3609 6615 1009 7764 7297 6929 5045 5046 288 6938 11171 55810 687 93986 9789 1785 6667 29954 10585 60559 283 3570 329 3170 9314 331 54971 3066 5925 6597 117581 57531 821 8289 387893 84231 1520 1508 9861 6233 7316 3717 10213 5706 7020 7414 5707 5708 5709 1013 5700 127544 5701 5702 5704 5705 4790 1002 5682 5683 5684 5685 5686 81607 5717 5817 5718 27085 5719 5818 5819 11047 57863 5713 5714 94234 7979 5690 5691 5692 5693 5694 7311 23705 5970 7291 283106 5695 7314 1010 1008 5687 4193 1007 5688 1005 1004 5689 1003 1001 1016 1514 1015 1012 3572 7490 10399 54737 348262 253559 80149 5315 7750 10009 3569 60436 7088 25945 9159 28513 9855 7074 1460 1459 1457 9839 4609 5931 1000 94239 6935 4613 23396 1488 1487 3728 54145 58505 9743 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 7529 890 7532 7531 11200 8900 2810 1111 7465 891 995 983 7534 10971 7533 PTK6 REGULATES CELL CYCLE%REACTOME%R-HSA-8849470.2 PTK6 Regulates Cell Cycle 1027 1019 5753 595 1017 898 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-HSA-3249367.2 STAT6-mediated induction of chemokines 29110 340061 6778 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking 1601 2017 84251 1294 29127 81631 26119 10987 53632 4952 6814 5879 160 5874 161 163 57679 1175 1173 3949 154 10093 10092 5563 5564 10094 5565 10097 10096 5571 1129 10000 1856 4124 84364 2799 1362 7532 11311 4641 207 208 4644 9685 7164 388552 10109 7163 8976 6272 4627 286451 6643 27131 55330 54885 152503 10552 26258 2804 3630 84062 9698 1176 64746 23557 57134 4121 10905 22878 22879 221960 79890 2665 8867 80006 2664 25782 23682 57706 10260 6764 11031 23258 9909 1639 79961 116442 84315 2697 60684 23011 2706 10981 5866 84079 160518 163259 126432 22930 22898 22931 54453 11015 55667 27147 3257 54734 51622 79958 259173 89781 201627 9610 163486 414918 201475 1122 51112 4905 10945 23048 54874 55860 51164 2890 10671 636 23299 93661 5050 84516 5049 57369 10052 84694 1213 1211 10133 8546 5873 2589 1453 3092 22920 2590 117177 6233 7316 10540 4218 9525 51160 55048 89853 23265 11267 51028 155382 137492 27183 93343 7251 1956 51271 7039 79720 378 84313 60412 51510 51534 54536 2810 9371 10121 10640 7311 11336 7314 149371 6305 55763 3797 8729 56894 2705 55770 9321 127534 219770 11127 125111 375519 2702 2701 2700 8766 2709 2707 2703 10804 57165 81025 57186 79058 57148 10890 5872 23216 6517 9882 51552 9847 11258 1080 9341 23647 22836 8907 8774 8775 130340 3482 79571 22796 10053 1174 7879 9382 8905 57589 10139 162 51560 143187 10652 164 10618 3998 60592 51209 25839 5870 22818 9712 26286 90196 10228 22820 122830 84316 6453 83548 400 63908 9146 57511 6456 1121 60560 10466 8027 9827 6455 374403 2060 11021 9367 8674 9363 8677 84958 8675 23062 30011 339122 57465 23163 6293 6457 51762 2800 867 79735 51542 10254 84342 27342 738 4122 83874 91949 83452 2803 4943 11345 7110 55275 8408 10244 9135 23637 9648 729873 338382 6811 64786 125058 11316 9230 5898 54662 26088 26000 55357 51256 57533 7534 10971 5867 11337 7533 9609 8398 11070 7529 347517 10226 11014 5878 5868 5869 338 9276 1315 1314 808 26958 7531 9318 4646 51014 351 23423 24137 2801 51272 4253 2873 51138 1759 6708 6709 285643 286 287 288 7248 51332 6711 6710 6712 372 381 9527 26052 7249 685 54732 255324 2069 51226 1839 57731 127833 8673 4074 2647 1777 6844 375 1212 3312 6857 10717 6845 8906 9179 23431 134829 157807 81567 1522 1785 11154 51128 9829 27314 5864 9871 8322 9632 10427 7474 1523 10802 10484 6572 8533 1604 64708 92421 27243 10980 128866 9267 9342 50813 9265 9266 27128 250 9950 10920 27333 79643 51652 29082 9585 55083 23046 91782 55605 113220 6810 25978 3833 3834 90990 55850 23095 10749 60561 830 55614 832 146909 6836 55582 23303 124602 53407 64147 829 221458 662 51594 547 185 8655 3798 3799 9183 375056 1062 6869 5321 5048 156 51143 6396 1781 1780 1778 81930 81846 84643 3796 64837 1783 26153 147700 10112 9493 3831 3832 3835 140735 56992 79090 408 5265 89953 11004 409 6399 5861 23243 22870 2153 22872 2348 10175 5537 377 10972 9554 9117 11196 64689 126003 55291 23256 1075 58485 254263 25956 55014 81562 51693 2157 551 122553 8615 966 554 10342 27095 149111 9919 81876 83696 10959 10113 90411 4738 10282 7082 4012 26984 2512 9570 51399 89866 79748 7109 128637 10960 2495 7018 7037 23208 9185 9856 8301 115548 374 1861 55738 5286 915 1950 27348 23149 29924 917 26130 85439 29763 51429 9892 920 50618 22905 2580 382 25977 3267 23396 9026 29988 51422 273 274 58513 157 950 143425 22848 8773 29993 8218 8871 9322 4036 286749 3575 90019 55707 11252 112574 29978 29979 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 96%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 1798 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 96%5654736 Signaling by FGFR1 23767 161742 200734 23768 5515 23769 5516 5518 10817 5335 2549 10253 8569 53834 3730 7311 7314 867 4893 6654 2254 3265 5781 2251 27006 8074 673 5295 2249 2248 2247 2246 5290 6233 5594 7316 5595 7049 2255 10818 10755 8817 26281 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 857 7529 4088 4089 7532 7531 2810 2033 5170 6667 7534 10971 7533 5706 7329 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane 8898 55697 9108 4534 9110 30849 9896 66036 5286 5289 200576 RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013405 RHOD GTPase cycle 9341 394 23092 1729 7879 4001 29984 79180 3998 29127 81839 5364 1627 87 2010 23344 55114 8987 55789 4162 7112 80728 9217 81624 23592 55240 832 26092 3930 27145 101059918 84681 120 94134 857 5361 5295 56924 5296 144402 51479 9497 9590 7444 10424 123720 9743 2909 158747 57584 57144 392 ABACAVIR ADME%REACTOME DATABASE ID RELEASE 96%2161522 Abacavir ADME 161823 9429 5105 6582 6580 6581 22978 124 5243 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK 1956 4893 6654 3265 6197 6196 887 6195 2520 5594 5595 5598 5578 4314 1839 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428559 Proton-coupled neutral amino acid transporters 153201 206358 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951911.2 RUNX3 regulates RUNX1-mediated transcription 864 865 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer 374 1956 7039 685 1950 255324 2069 1839 FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 96%9758920 Formation of lateral plate mesoderm 3549 2294 2626 652 6469 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) 3373 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy 65082 7405 23339 26276 7284 11311 57617 55823 27072 64601 81631 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates 4056 2948 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling 344 213 345 9388 348 3931 1071 335 9619 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 2475 245972 245973 55004 8649 155066 9114 51606 9550 64121 523 58528 10542 525 389541 526 28956 527 57521 528 10670 529 6009 8992 153129 90423 127124 10325 51382 533 534 10312 9296 8131 64223 201163 55846 23334 144577 23677 84219 10641 81929 652968 96459 83667 729438 79726 154743 9681 57600 54468 6396 11133 27244 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%416700 Other semaphorin interactions 3672 23129 10507 54209 5361 5362 9723 5365 7305 57556 9037 971 91584 10154 8482 3688 5788 64218 80031 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9915355 Beta-ketothiolase deficiency 38 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%168256 Immune System 8331 7004 8337 7003 8334 7005 8335 2353 1729 5062 10613 117145 100128731 192670 27161 8341 8463 8342 8347 8348 8345 91445 6048 26523 8340 10987 53632 2354 2475 91319 8338 4791 10956 85236 8349 5879 6185 23112 4771 23476 6184 57690 11001 2932 192669 746 30 79109 1603 5781 2034 3123 51411 3122 27248 3120 8370 3119 3118 146850 79139 151888 3115 2146 3113 998 5777 51009 4343 6400 3013 3127 3126 3125 55615 255626 23308 84061 5562 5563 6772 5564 6774 5565 3021 3018 3017 3014 978 80380 3932 5571 7991 64223 474382 201595 10000 3703 8970 128312 27327 9020 3716 83439 55766 1650 8726 8968 10331 7532 23533 3727 51176 7525 207 208 7409 653604 7415 84661 8503 11091 25937 5133 8764 23512 1326 5928 5929 2534 1445 467 3609 3718 3554 7297 1901 6773 3460 29760 3459 973 974 3454 2342 2339 6921 6923 6950 8887 26272 26234 6468 10694 10576 26190 26270 10383 55294 2934 60 10517 84261 81035 842 7157 26224 54461 8877 9883 129401 9688 23225 3836 4927 23165 55706 23636 9972 4507 9631 7175 11097 23511 8086 8021 53371 8480 10762 6059 24145 57126 7040 1213 1211 26253 8411 64170 80231 3663 50856 64581 64145 170482 10462 93978 338339 4360 945 3309 5627 811 11314 9636 246 3304 821 3662 5873 3320 3837 3838 3839 5610 5611 23200 79895 2633 402569 3840 3841 6175 5266 538 640 8876 23250 196527 1823 10396 51248 121260 327 5493 5320 9218 5338 8563 10555 9775 79888 6657 8575 6895 634 7220 7226 427 6935 9140 9474 2335 3920 7448 3911 8907 55593 130340 4502 3105 567 10053 1174 8905 162 1234 164 5698 5699 5696 5720 5721 7322 997 10454 7334 7335 5588 7189 10235 257397 115727 23118 5880 6195 6279 683 6280 7534 326624 5443 64135 3442 3441 3440 23586 80143 1435 84282 57506 3452 401258 3451 3449 3448 8600 3446 3445 3444 3443 7706 5878 5869 759 53916 53917 1315 7498 7410 3615 3614 10451 2939 4831 2215 6093 5930 71 7431 5329 3326 8514 5045 51719 9761 55004 3693 8649 1977 301 1981 9545 28956 5782 143662 118430 6844 6616 6804 4582 5199 4583 2517 4584 4585 4586 200958 51128 727897 56667 9871 9632 10427 10071 94025 8895 140453 4588 4589 283463 10802 394263 10484 8904 8772 3553 4257 834 9342 837 838 7332 5071 83737 841 8737 329 11035 51816 3606 7186 3660 10273 57162 79792 330 3240 1991 5724 6386 3552 1687 2358 3146 6836 3313 4314 2147 11119 11118 696 7320 56244 11120 10385 153579 10384 79908 3827 4842 3710 80228 8566 84876 6947 3937 7535 27040 9398 2533 3702 815 7462 816 817 818 6786 10768 3708 3709 5566 6197 6196 7295 93100 410 5608 5609 6416 5601 5602 5606 933 8741 3080 4179 5269 5598 1361 1380 5328 10877 10878 730 731 27202 3569 710 732 7294 930 975 733 735 3456 81494 3576 5599 3078 3075 1370 1191 3426 1369 722 725 728 729 5335 596 598 1938 1915 102 6868 3575 4680 5743 240 4317 721 727 629 717 718 1088 8972 8678 1118 201254 64386 101 1965 8894 1968 4843 140885 4973 1084 6402 1525 120425 4267 965 54210 1154 2690 5618 2689 2688 1442 8835 22863 317649 1052 4318 6993 10326 51125 909 22914 56253 56654 89858 910 23765 911 912 4068 3803 10450 3804 684 3805 3806 374383 8778 925 10666 3802 5589 285852 23547 29121 10990 9868 4345 10871 10870 3811 27180 3812 27181 353514 114836 124599 117157 2213 5094 342510 3586 4627 3820 80216 946 92610 3821 3824 1982 126014 100132285 340205 10219 146894 57823 10859 11024 2308 11027 11026 7097 7096 959 135250 2634 131450 9436 9437 112744 259197 23601 79168 29992 29990 10225 89790 4277 114132 51348 11126 3654 11006 84818 339390 100131439 4988 9976 3107 100507436 3106 80329 79465 3903 6627 3904 79865 27036 3134 146722 3133 10288 6614 196500 3135 3683 25820 55824 115361 10333 3181 3185 835 3676 10628 4057 163351 843 604 8672 847 3458 1278 2923 23327 1654 4939 3605 6515 2176 4718 6672 7422 200845 6727 5780 5771 5783 5784 26469 25930 84867 26095 8809 6597 59307 27178 10068 5778 114609 948 11213 6271 8784 353189 84676 475 6347 6556 11059 9588 2950 6647 2810 5817 114907 2821 5819 2206 2205 7291 22861 1514 1513 3572 1515 9021 2625 5315 3958 3726 24138 81603 79097 4600 10410 11074 2317 55223 53840 91543 3430 201626 3306 3305 3664 3669 3429 199990 55120 138050 10612 3437 55128 3977 3434 3433 51447 91442 6041 1958 54739 10964 57697 117854 23321 80128 6622 51127 10379 22926 9470 80233 7726 79132 85363 54476 2175 54941 3383 10475 80263 2188 2187 3394 22875 2178 4599 374395 115362 10549 23087 201294 1116 2189 4261 2204 1476 10581 9830 80301 7412 932 23650 10875 820 10107 2352 2635 116844 4938 387263 5229 10857 3608 10346 114790 124583 10437 388698 388646 963 4940 388697 25939 4281 968 83716 2537 127829 103 8638 4332 8519 10493 160364 79930 9798 8804 23218 5553 5795 5787 5547 4353 25840 374403 56954 11322 5799 23317 55754 4869 8836 11333 5728 23406 64114 89777 57826 566 6317 9961 8993 4033 25801 221 3562 56888 55313 3559 8635 10321 3558 1378 9725 10562 441864 6590 84443 51646 5273 8398 54918 5036 29952 199675 5284 154664 9522 9535 8560 6036 6278 6037 55 6286 25798 25797 7130 6282 387921 10394 11240 5770 175 150372 11010 23593 10043 100049587 3916 51806 222487 83858 22918 2717 1992 80142 8288 9145 5300 57020 258010 1774 5775 84766 2760 3848 84514 79169 94103 26578 5912 5806 23071 84418 2896 729230 1230 2289 1235 54778 4985 56729 2357 3579 3577 317 5660 8621 5473 6351 5371 6352 6356 6348 6349 6364 6363 6367 7323 2919 80196 2920 25 26191 4088 64750 4092 3627 55176 9902 6890 6892 6891 29927 6810 23480 50489 10952 830 832 829 4982 27071 608 284266 8995 10673 7077 5068 6097 7076 23495 7293 7292 60401 117159 130120 64167 4904 1113 3347 3346 149954 55600 84174 51297 9966 140683 6039 3809 128178 3810 3813 3822 92747 114770 114771 6503 338324 115650 8718 8740 8744 8742 58484 8771 57154 8792 3845 51330 84659 51752 939 943 944 116842 1437 970 1436 128859 10578 4025 4055 4050 4049 57119 57115 10913 1896 3604 122665 3717 2244 2266 7414 3310 8826 3818 2161 5894 2243 5908 4048 245972 245973 3163 155066 9114 51606 9550 2512 523 525 526 527 528 529 8992 90423 2495 127124 23545 51382 533 534 535 10312 3934 50617 9296 55832 29110 147945 3661 23220 81030 2207 7124 1440 3557 3976 2208 7132 7133 7850 3593 3592 3588 3587 11069 10411 12 14 1 5175 10577 6813 5034 967 160 161 163 2 5768 29116 197 2162 1072 1175 1173 3273 5567 5568 3417 5004 230 5005 2548 2683 2799 5834 5836 6382 10855 2588 28988 960 3101 178 1639 55276 6888 245913 5211 245936 245937 245938 245939 503618 613210 613211 245930 503614 245932 5223 245911 245934 503841 641517 117285 613209 400830 1673 4125 140850 1672 245927 245928 4126 245929 245940 55894 81623 100133267 140881 26007 644414 504180 2992 3984 5236 51071 226 929 7187 9641 353376 1540 148022 10010 10133 7128 2323 4860 272 353 196051 23646 84513 9466 9987 654483 27250 1265 5306 10148 9244 9049 6775 149233 3936 4282 5055 3595 3594 246778 3563 4128 3560 1439 1438 5495 3568 3567 1727 9451 5023 3565 3596 8807 54014 5896 5897 85480 3574 64109 51316 10890 51552 387 5971 3385 3384 9252 30835 79923 391 163702 282618 9341 3603 6809 146433 200081 5657 5803 26 7879 5337 10788 3688 63916 1794 1793 8987 23191 7087 3684 3695 8694 961 3687 3689 3386 2171 302 3685 5747 27 8453 4650 51466 4690 55740 4313 6655 10487 7408 5476 9655 9306 4758 29099 2002 23412 8878 8673 375 3312 6845 81567 1522 1785 9446 3578 3581 5289 2247 8660 30849 54106 9846 3667 3570 25852 1441 8651 154881 23608 118788 6478 7325 50852 6477 131405 7006 283807 10019 221687 79654 51088 9616 90678 7318 7317 56658 7319 10533 3093 22888 9870 7336 4069 1471 150726 10425 64718 118424 57630 23295 55336 7327 3015 6406 7326 197131 9867 7276 7328 81619 4734 10422 54926 9520 728358 417 65264 10193 1671 1670 10075 1668 93611 127247 5645 401036 5646 1669 79791 55585 57520 3798 89910 3799 51665 7337 51666 26091 55905 63891 63893 142686 57531 4311 142685 55236 290 51676 142689 223082 22954 91694 10159 10293 9666 51320 80204 10616 57542 51444 11146 135892 55008 6047 4064 6049 3929 671 23376 23014 9450 57674 143279 25793 84231 11275 89122 9320 55819 64410 90025 222235 84937 140691 51465 54850 140456 140458 90933 140459 90135 25897 25898 9690 146330 140460 140461 140462 255488 114088 54620 23352 868 8916 115290 6737 7704 55958 8139 390594 127544 55284 84961 27246 8924 122769 8925 64320 9354 81559 55175 84708 7174 27252 51130 642 51132 26046 9903 9246 4591 25847 158506 92369 55182 126433 26259 64219 7064 23304 201456 80028 144699 899 84861 92912 10477 26268 55070 90293 84727 92591 26263 26267 53339 10489 285231 89890 4012 9820 26235 26118 79176 26232 55521 84085 4008 9817 51725 9039 26249 25831 11141 8065 55658 140739 51619 9040 148581 79876 79754 84541 9730 154214 51191 151636 80176 23194 7428 9604 136371 10324 1143 3082 10970 8773 9180 1536 10538 54472 1535 133396 10458 56300 27189 1489 58985 4688 132014 1271 55845 4689 1270 27179 9235 3566 27177 3590 3589 4312 4692 10787 8808 3598 8936 3597 6624 10152 4215 2185 23529 90865 55540 29127 5008 29949 4170 3071 116379 10163 53833 53832 55801 26525 653361 59067 282617 11009 282616 50604 84868 10006 50615 50616 386653 84639 58480 3601 3600 708 3965 64806 9173 6518 5663 23385 9844 3055 926 64333 10093 10092 10095 4210 10094 10097 23526 10096 10810 2268 7454 7456 5027 147179 10910 1511 4620 2209 4641 2214 2212 4651 29108 644150 114548 54509 26999 5336 4644 719 10109 8976 158747 6850 695 10552 9051 51517 23197 2444 3561 2665 3635 3636 11031 122618 22931 84329 210 55860 51164 10671 93661 84516 5049 5788 8767 4615 54209 84166 4205 6285 6288 11274 64127 7305 6283 51295 51135 4214 9683 9684 7100 10392 28512 79155 57161 79671 177 121457 246330 5909 81793 28511 3656 9097 466 51231 1849 1848 1846 1845 203068 22920 9861 8454 6233 7316 5579 10540 10892 10213 6885 5706 23291 5707 5708 5709 1147 84433 5700 5701 5702 5704 5705 4790 5682 5683 4792 5684 4793 5685 4794 5686 5717 5718 5719 8945 11047 9371 5713 5714 7979 5690 5691 5692 5693 5694 10121 7311 5970 5695 7314 6500 3551 5687 5688 8517 5689 5966 8915 7341 8554 3797 6095 7329 80184 11127 11258 51082 84265 55703 11128 51728 9533 27297 661 4361 10623 171568 55718 10622 10621 51529 3482 7321 8881 64682 11065 8697 7324 10393 29945 51209 27338 5870 29882 246184 983 996 51434 51433 6456 1499 30011 999 867 6714 4893 6654 3265 9261 2889 1399 1432 1398 5898 5594 5595 6300 6464 5906 5600 7867 7529 5603 5604 383 2033 3043 23643 3162 54920 2316 338 4208 7099 4780 2885 6777 6776 1387 5292 1386 1509 4772 4773 5451 25780 5534 2280 4775 808 5478 5530 5532 10125 4001 351 24137 10018 356 823 1759 6648 2309 3725 4478 6709 57153 285643 9978 6712 26052 4684 23114 976 5864 80331 47 84658 1604 8452 84078 2990 3074 2720 411 1019 595 51343 6502 1027 1026 1974 1973 2322 8655 2519 1062 80341 991 348995 5580 57122 51143 55746 81622 23279 7098 79023 51284 1520 5641 51311 1508 7184 4153 6396 378708 2220 1781 1401 1675 3004 712 1780 78989 713 1778 714 81930 8547 139716 715 23108 6494 84643 10584 3796 716 4846 5648 2219 2887 7520 64837 1660 1783 26153 2547 115004 147700 1512 5591 81844 1510 5903 11277 10112 9447 1519 5519 332 170506 8722 9493 51428 340061 10120 3831 3428 3665 3832 3835 9208 6778 83547 140735 972 197358 5515 56992 11004 5265 89953 5516 3112 5518 3111 114876 3902 3109 22872 3108 79980 79902 9554 5525 5526 5527 5528 5529 1075 5617 58485 966 1832 1828 836 5317 5440 5441 5434 5435 5437 5581 4297 1460 1459 1457 4609 5931 8405 915 10413 916 917 3091 4067 94239 9070 920 4613 6793 11160 4751 9402 53831 253260 57761 29126 142678 51422 3659 5294 5295 5296 5058 1493 5290 2040 5170 3728 5291 5293 54145 58505 940 941 942 6932 6934 58508 5063 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription 10621 5434 6908 5435 5437 6621 55290 6619 7702 6618 4781 10302 4782 6617 6741 4784 4774 51082 84265 55703 112495 11128 51728 9533 9330 27297 661 2976 5440 10623 5441 2975 2972 2971 171568 55814 5451 9328 9329 55718 10622 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 96%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 1387 5579 1437 861 865 3958 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system 3557 3566 5743 27177 240 3976 2208 3590 3589 7132 4312 7133 4692 7850 3593 8808 2353 3592 3598 3588 3597 5062 3587 6624 4215 2185 23529 90865 8678 55540 5008 29949 4170 116379 53833 201254 53832 55801 26525 59067 282617 11009 282616 50604 84868 50615 4791 50616 6813 1965 386653 8894 84639 58480 5034 3601 1968 3600 3965 4843 64806 9173 5781 3123 3122 3120 3119 3118 2162 3055 1072 3115 3113 998 5777 1154 2690 5618 2689 3127 2688 3126 3125 1442 8835 6772 6774 317649 1052 4318 3932 10000 9020 23765 3716 1511 8968 684 2209 7525 207 208 7409 653604 8503 5336 8764 1326 2534 3586 1445 3609 6850 80216 92610 1982 6382 3718 3554 7297 2308 959 1901 6773 2634 3460 29760 3459 112744 960 3454 2342 3561 3654 84818 2339 3635 4988 3107 3636 3106 6921 6627 6923 3134 3133 6950 3135 25820 115361 3181 3185 163351 604 8672 6888 60 3458 1278 7157 8877 4939 9883 3605 129401 9688 23225 3836 4927 23165 2176 55706 23636 9972 4507 9631 7175 11097 23511 8086 8021 53371 8480 10762 6059 8767 4615 7040 6672 84166 7422 4205 6285 6288 11274 7187 64127 6283 3663 51135 9683 9684 10392 5780 28512 5771 79155 5783 57161 79671 5784 177 26469 25930 121457 3309 84867 246330 26095 2323 8809 28511 3656 6597 59307 9097 27178 9636 466 10068 5778 51231 1849 948 1848 11213 1846 1845 246 3304 821 8784 3662 3320 3837 3838 9466 3839 5610 9987 5611 654483 27250 1265 5306 6347 10148 9244 9049 6775 149233 3936 4282 5055 3595 3594 246778 2633 3563 402569 3560 4128 3840 3841 1439 1438 3568 5495 3567 6175 9451 6647 9861 8454 6233 7316 10213 6885 5706 23291 5707 5708 5709 1147 5700 5701 5702 5704 5705 4790 5682 5683 4792 5684 4793 2810 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5970 7291 5695 7314 6500 3551 5687 5688 8517 5689 3565 7341 3596 8807 3572 8554 6095 54014 5896 5897 85480 3574 64109 9021 2625 7329 8563 9775 3726 24138 81603 79097 4600 10410 11074 2317 55223 53840 91543 3430 6657 201626 3306 3305 3664 3669 8575 3429 6895 199990 55120 10612 3437 55128 3977 3434 3433 51447 6935 91442 6041 1958 54739 10964 57697 117854 23321 80128 6622 51127 10379 22926 5971 9470 80233 7726 85363 9252 2175 3383 10475 80263 2188 2335 79923 2187 3394 2178 4599 115362 23087 2189 163702 4261 282618 10581 3911 3603 6809 9830 146433 7412 200081 23650 4502 3105 5657 10107 567 7321 2635 5803 4938 5229 3608 10346 1234 10437 7324 388646 4940 25939 4281 2537 103 8638 8519 983 3688 5795 5696 4869 5721 7322 867 10454 6714 7334 7335 4893 6654 7189 3265 257397 9261 23118 2889 3684 3562 1399 3559 6195 1432 1398 3558 5898 3687 3689 5594 5595 7534 6464 5600 5443 7867 64135 3442 3441 5604 3440 23586 1435 57506 3452 3451 3449 3448 3446 8600 3445 3444 5770 3443 7706 3162 54920 302 2316 5300 27 5775 759 4208 2885 4690 6777 6776 5292 729230 1386 1230 2939 2289 4313 5451 6655 4985 5478 4001 71 7431 351 10018 356 2357 6648 2309 3725 4478 9978 9655 5045 9306 1977 301 1981 4684 2002 5782 8878 6844 375 6616 5371 6351 3312 6352 6804 6845 6356 4582 6348 6349 6364 6363 6367 9446 3578 3581 7323 2919 2247 2920 8660 9846 3667 3553 4088 834 3570 1441 8651 841 4092 329 7006 10019 3606 7186 9616 3660 7318 57162 79792 330 3627 5724 3552 595 6810 3146 4734 1027 1026 1974 1973 829 3313 2322 4982 608 4314 8995 10673 6097 7076 23495 7293 7292 60401 4904 84174 9966 348995 128178 5580 57122 3929 6503 115650 8718 55746 8740 8744 8742 8771 8792 23279 51330 3845 79023 939 943 944 7184 1437 970 6396 1436 378708 4055 4050 4049 139716 10913 1896 3604 2887 3717 1660 815 816 6737 817 818 5903 5519 332 5894 3665 6778 5908 5515 5566 6197 5516 6196 5518 79902 9246 5525 5528 5617 5608 5609 6416 5601 5602 5606 836 8741 5598 9039 3569 11141 8065 9040 3456 3576 5599 3934 51191 5335 29110 4609 3661 596 598 3091 4067 920 9402 3082 6868 3659 5295 5296 5290 9180 10538 5291 54472 5293 133396 56300 27189 3575 1489 941 58985 942 132014 1271 1270 7124 27179 9235 1440 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%180336 SHC1 events in EGFR signaling 374 1956 4893 7039 685 6464 6654 1950 255324 3265 2069 1839 PHOSPHOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%1483257 Phospholipid metabolism 5337 56910 248 4952 5728 9663 8694 146850 5867 8398 84649 2820 129642 255043 8605 11145 10162 123745 79887 255189 11343 50640 50487 151056 54947 64900 150763 23175 5868 23533 5305 8503 10390 9468 126969 1120 27124 162466 204962 8867 10809 3635 158835 80736 56994 3636 1119 57153 5130 23446 84879 171586 58488 10400 122618 57104 375 3032 3030 590 1103 43 57678 8895 51365 56261 63874 5289 57110 27132 283871 64850 9489 9362 55500 114971 55224 5833 154141 9926 23761 54675 30849 347516 23659 114884 80339 117245 8904 54979 8760 114879 114882 85465 5920 79143 9600 1040 57605 83394 10423 90809 5783 23646 9110 5321 55750 8897 8776 9107 55361 81846 22874 22876 84725 57664 54477 51763 3631 126282 8821 7179 65977 59339 59338 51573 55697 9108 4534 55613 133121 80230 66036 284161 375775 5287 5288 93492 10908 8394 79153 8395 64419 54893 377 25816 5298 9896 388121 200576 660 81544 54545 79626 55300 5297 8898 22908 6305 9791 8396 81490 8399 374986 5320 137964 5322 26279 283748 201164 6901 81579 84803 55326 80821 56894 56895 51205 5338 10554 253558 5319 10555 8443 22925 200879 64600 23259 23171 100137049 84895 254531 79888 149998 2819 30814 1460 1459 1457 5286 51552 23396 5294 5295 5296 5290 5291 23760 56623 8871 5293 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion 2157 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 96%3781860 Diseases associated with N-glycosylation of proteins 2683 79087 199857 85365 29929 79868 10195 79796 9526 56052 79053 11253 1798 91869 440138 7841 4758 5476 4247 2720 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 9154 291 64078 292 293 23568 3177 222962 9153 55315 402 2030 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-HSA-375165.5 NCAM signaling for neurite out-growth 1297 1293 1292 1291 2675 6900 5621 5623 1287 64096 5786 779 6708 6709 1463 4893 51332 6654 6711 6710 3265 8128 6712 7903 776 5594 4902 5595 8912 8913 8911 9048 4684 57731 2668 775 2674 5747 1286 1285 782 256076 783 1284 784 1282 785 9252 1299 1298 2534 375790 131873 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME%R-HSA-5619046.4 Defective SLC26A4 causes Pendred syndrome (PDS) 5172 RHOQ GTPASE CYCLE%REACTOME%R-HSA-9013406.5 RHOQ GTPase cycle 9341 394 23092 10395 57580 8826 26030 128239 85360 5062 7879 11060 10298 81839 28964 8874 6453 55114 143098 4983 23380 55789 2697 55004 115703 81624 11135 55240 6510 998 10602 7037 54438 10435 857 23580 23048 144402 5058 8773 8476 2040 9497 3728 9578 9322 23513 1080 200894 9743 9815 2909 8976 23229 57120 57584 392 THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome 29108 9447 834 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 96%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 92421 27243 29082 128866 91782 25978 5289 8678 79643 81631 7405 51652 30849 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 96%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 331 317 842 836 54205 840 56616 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins 23636 5903 9972 9631 7175 11097 23511 8086 8021 8924 53371 10274 8480 10762 8535 8243 7508 79902 5885 197370 493861 648 79677 56160 54780 6015 6672 1912 1911 286053 23137 7341 80012 84733 8554 6045 51588 6612 7329 1029 6613 142 7486 5371 672 57332 165918 5893 348995 9126 57122 641 7703 6117 55746 9656 23279 79023 7518 6396 51564 9883 129401 10735 1069 9688 23225 4927 6996 23165 55706 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME DATABASE ID RELEASE 96%9827857 Specification of primordial germ cells 639 7022 7852 5460 342977 652 9139 79923 10630 8320 54790 64321 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%74752 Signaling by Insulin receptor 3630 117145 4893 245972 245973 6654 3265 5781 155066 9114 51606 9550 3416 523 5594 5595 525 526 527 2323 2322 6464 10818 528 529 8992 90423 127124 23545 51382 533 534 535 537 10312 50617 5770 9296 5792 2549 5140 9965 57761 5289 2254 2252 208 2251 27006 8074 5295 2249 5296 2248 2247 2246 5290 152831 5170 8823 5291 8660 30849 2264 1509 2255 2887 54106 3643 9846 3667 8817 26281 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702614 ponatinib-resistant FLT3 mutants 2322 METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids 5743 6555 6554 240 200931 123264 10998 80765 117145 26230 56910 248 26119 4952 5264 51129 1384 23600 283927 10062 54677 390916 26063 8029 19 1962 122970 215 8540 11001 116519 3295 30 10005 51179 8310 2053 570 213 336 55825 8309 6342 146850 403313 1718 10965 6307 91452 50814 39 64801 10682 26061 51478 91734 4056 5567 55588 5568 5563 80306 5565 231 2678 6483 64174 6487 2687 23533 30815 1800 8503 9412 54600 400569 55090 5730 23097 34 1666 1632 6837 10390 9468 1120 27124 8867 162466 10809 3635 56994 3636 1119 5130 84879 171586 58488 10400 81857 80777 122618 9334 9331 6610 219541 55512 54797 8647 2629 2101 10599 6720 57104 8800 5244 1024 28234 60481 7069 63924 23389 2180 8705 9971 9420 1593 1581 1646 6718 1645 80270 1109 8877 405 239 10025 211 23179 892 6822 2524 2523 10001 25942 6609 9600 1040 57605 83394 10423 29079 5467 55289 79966 10858 1594 1584 51302 51102 5783 9612 9862 4051 4363 8644 11283 22949 948 126410 1580 1149 241 83401 1374 57834 246 284541 376497 23646 3837 55750 4199 84246 5901 9443 9441 9442 8714 84002 2876 9440 51586 9439 2194 9477 7296 112950 55300 5297 8898 22908 6305 25979 8396 7376 6256 8399 7421 374986 5320 5465 2638 137964 5322 9218 3930 26279 6095 283748 201164 6901 81579 84803 55326 51588 80821 56894 56895 5468 7329 51205 6613 5338 10554 253558 1586 5319 6715 10555 6716 8443 22925 200879 64600 2877 23259 23171 2874 100137049 84895 254531 79888 149998 2819 30814 9282 10478 1583 427 51552 23760 56623 123 3292 5337 6916 5740 1582 6770 147323 83930 10948 706 134429 5728 9217 9261 221 9663 8694 6296 392636 35 2173 1892 2172 3033 142827 2171 5867 2170 80168 8398 84649 129642 2820 116255 255043 2169 8605 2168 11145 150379 10162 5443 2167 123745 79887 84498 346606 9967 8560 8228 255189 11343 50640 50487 646486 151056 3991 5499 54947 64900 646480 2713 2712 2710 51099 150763 23175 96764 5500 2033 5346 10226 11010 1589 1585 3284 6907 3283 80205 5868 335 8648 2717 10891 80142 4862 1081 51003 10499 10498 857 79718 6604 2760 9575 94103 8841 9611 5305 9572 1387 1579 23054 1545 5469 113612 8529 85441 406 8202 9915 29906 10728 81849 5476 79644 10825 126969 204962 79777 3291 80736 158835 3290 57153 866 23446 91012 23683 25865 8869 5660 142891 340485 53947 9514 29956 55331 388931 166929 165679 125981 79152 4758 9517 55627 4759 8706 7357 2583 204219 2581 253782 171546 29095 56848 8611 8612 37 7368 5587 339221 57704 130367 123099 4074 259230 124976 56624 79603 375 8613 94101 10558 55304 33 10715 3032 3030 151742 64781 3638 81537 51360 57733 590 2224 222 2222 2531 1103 3157 8879 6667 9968 5007 43 51128 9969 26031 9885 4800 4706 9023 4801 3294 4802 6309 51171 10654 51170 441282 9871 114880 9632 57678 114881 10427 114883 6713 6319 22937 4597 8895 79071 51365 51141 1595 56261 6721 63874 5289 1717 57110 9256 31 27132 32 283871 6579 64850 9453 4047 9489 4520 9362 55500 8720 114971 10802 55224 3422 5833 4598 9200 10484 47 154141 9926 9524 7108 23761 64834 54675 401494 30849 23205 347516 23305 23659 114884 79993 80339 6257 84869 253017 117245 8904 201562 51144 54979 55301 8760 114879 11000 114882 54898 5538 85465 197322 5920 51703 6785 22880 9374 2182 3293 81616 2181 51495 7923 109703458 79143 112937 64064 3074 56898 3073 79611 54511 38 79411 3158 3972 65985 2720 622 411 3155 5019 89944 90809 6584 183 5096 90390 4594 84693 166785 5095 4899 1455 5321 9110 1591 133522 5641 8897 8776 9107 55361 81846 22874 22876 84725 57664 54477 27063 158584 51763 3631 1376 1375 126282 58526 5501 8821 5742 7179 284486 65977 80221 59339 145482 59338 2274 51573 55697 873 2166 9108 4534 55856 55613 5444 133121 84188 788 80230 66036 5445 27306 284161 5446 5566 11332 375775 285362 345275 5287 80724 5288 3248 10449 2948 93492 114876 4048 84320 10908 247 8394 79642 414149 79153 1571 29923 8395 9536 64419 57491 54893 9415 84129 196 377 161247 1558 3992 25870 25816 50486 1557 5298 127281 9896 128486 388121 23597 1544 200576 55711 1565 660 27242 1543 1576 81544 641371 340075 54545 134526 79626 158833 1622 1573 410 27349 412 26027 29841 414 415 1559 416 9791 22901 81490 153642 347527 9429 120227 1588 112812 2232 2230 1460 1459 1457 5286 57761 242 23396 59344 2879 51422 5294 5295 5296 5290 8871 5291 5293 4036 SIGNALING BY RAS GTPASE MUTANTS%REACTOME%R-HSA-9753512.2 Signaling by RAS GTPase mutants 3845 4893 3265 SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions 10599 28231 9356 284111 8402 6566 682 28234 6578 353189 1468 53919 55867 9058 11309 126969 204962 345274 80736 57153 60482 23446 6576 551 23539 9123 6567 9194 133418 9376 6579 26503 160728 64849 116085 159963 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 96%5579028 Defective CYP17A1 causes AH5 1586 MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 96%1222449 Mtb iron assimilation by chelation 4057 DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o 54344 8813 8818 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes 6871 55683 55689 284058 55617 91272 23067 54934 10474 4297 1810 10445 8850 51562 26993 26009 3054 29915 259282 8473 112869 57325 84148 51105 22976 80335 2648 9070 9739 79447 30827 4221 51230 84661 11091 8085 23054 5929 11168 9757 58508 7403 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%74259 Purine catabolism 4907 9615 4860 7498 55270 22978 56985 131870 10591 11164 3704 84618 93034 30833 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME%R-HSA-210746.3 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 50674 4821 4760 3642 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 96%168176 Toll Like Receptor 5 (TLR5) Cascade 1147 5519 2353 4790 351 4792 5515 6197 6196 4793 5516 5518 841 8945 3725 7186 3654 8767 5528 4615 4791 57162 7311 5970 7314 6500 3551 84166 4205 10454 6285 7334 8517 6288 7335 11274 64127 7189 5608 6283 51295 257397 5609 3146 9261 51135 4214 23118 9683 6416 9684 5601 6195 7100 1432 5602 10392 5606 28512 79155 57161 79671 5594 177 5595 121457 246330 81793 5598 28511 3656 9097 2002 466 51231 5600 1849 7867 1848 1846 1845 5604 5599 7157 4208 9252 1386 8454 6233 7316 1326 6885 23291 80216 92610 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME%R-HSA-4549380.4 Defective ALG1 causes CDG-1k 56052 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME%R-HSA-9854311.2 Maturation of TCA enzymes and regulation of TCA cycle 122961 1431 2395 751071 57128 23410 135154 50 3418 6389 81689 54949 57001 38 644096 6391 6390 6392 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 96%9918487 Dengue Virus Genome Translation and Replication 1982 283208 51726 100128731 7431 4836 81631 2194 10525 10527 4666 8813 8818 7311 5034 7314 6185 6184 746 1603 7341 1977 54344 1981 1974 1973 10965 3309 811 7329 55666 3069 10313 9775 3304 821 84061 4904 3312 6238 8672 317649 9532 7353 3837 9789 3838 7991 10294 3839 5611 90701 335 201595 3703 2923 64225 8974 7514 5593 25777 54431 1650 54464 22937 689 402569 3840 3841 28972 26986 60559 5033 7415 6233 7316 58505 3836 23478 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs 8331 3013 8337 8334 8335 29086 10617 51720 672 84142 57559 2033 9577 79184 8850 114803 317772 8027 8338 92815 85235 7311 8969 221613 7314 23172 114548 6233 7316 580 10213 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development 3673 1729 192670 27161 891 25942 26523 5347 4233 1499 999 7299 23112 7306 1638 57690 595 2932 1017 192669 86 22797 6591 6195 1432 51520 1615 5859 4140 1026 4141 5077 5594 5595 7534 1908 7533 6595 3376 6597 3094 7965 6599 1906 6598 4343 9521 7545 5443 4157 7529 3065 1910 3815 27022 1435 25924 5917 257 8110 3662 6926 6601 8193 6603 3735 26039 6602 4161 6490 9255 6605 8600 5977 6760 8289 2766 4286 6663 5873 2033 79083 6662 5454 9274 3397 9275 2315 7030 605 4160 2058 54843 4159 7942 201595 10000 10891 4935 27327 7514 5054 83439 6604 7532 51176 208 23411 1387 4644 7020 7531 7391 994 3978 4174 4171 7341 9114 51606 9550 523 526 57492 527 528 529 8992 7329 1029 533 672 60 6657 23405 596 597 6909 634 7837 5829 1000 89780 10085 427 6935 727936 7015 79444 4308 6932 6934 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis 60490 80025 80347 53354 79877 79646 79717 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex 5708 7090 5709 5519 5700 5701 5702 5704 139285 5705 54764 5682 5683 5515 5684 5516 5685 5518 5686 5717 5718 166 5719 8945 11047 5713 5714 7979 5525 5690 5526 5691 5692 5527 5693 5528 5694 5529 7089 7311 1499 5695 9978 7091 7314 6500 5687 5688 2932 5689 7088 3065 324 10023 8312 23401 83439 1452 51176 1488 1487 9861 8454 6233 7316 10213 6932 5706 6934 5707 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 96%8934903 Receptor Mediated Mitophagy 1460 9140 1459 9474 1457 84557 139341 8408 81631 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events 2770 2781 55970 2773 107 108 109 5581 5583 353299 111 6004 54331 112 5580 113 114 59345 115 8601 5578 150 151 2793 152 2792 346562 2791 5588 2790 2788 2787 5582 2782 2786 26575 2785 5999 2778 2784 5579 2783 10681 51764 196883 94235 2771 10287 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 96%4793950 Defective MAN1B1 causes MRT15 11253 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139910 Activation of BMF and translocation to mitochondria 90427 5599 140735 SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo 7529 9113 23286 92597 154810 26524 55233 7531 51421 60485 6788 6789 261734 9414 7082 25937 836 1856 10413 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity 7314 30011 6457 867 10254 3082 26018 5770 5771 6233 7316 9146 9101 5795 6456 4233 8027 6455 2060 7311 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655332 Signaling by FGFR3 in disease 2261 4893 6654 2254 3265 5295 8074 2249 2247 5290 2246 5335 8823 2549 10818 8817 26281 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 96%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 6613 10055 10054 25950 6612 7341 7329 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) 4967 23530 2395 3421 751071 4191 57128 3420 135154 50 3419 3418 6389 54949 38 6391 6390 6392 122961 1431 92259 1738 23410 2271 8802 10131 8803 8801 81689 57001 644096 1743 SIGNALING BY LTK%REACTOME%R-HSA-9842663.1 Signaling by LTK 5296 5290 5291 285016 389658 6654 3667 4058 10188 5295 2885 ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins 920 728358 417 1671 1670 1668 5645 5646 1669 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation 1147 121260 3551 8517 80231 3663 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin 4067 2057 2056 23533 4893 6654 3265 5294 2889 7409 5295 1399 6777 6776 5290 5335 5291 8660 5293 5336 2549 6464 3717 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 96%9909396 Circadian clock 7321 6097 1374 6096 5499 96764 5500 2033 6907 80205 7942 8648 10891 4862 5054 10499 10498 79718 6604 4208 4209 1453 10135 9575 8204 64784 8841 9611 23411 9572 200186 1387 23373 23054 1386 9861 5469 8454 85441 6233 406 7316 10743 10213 5706 23291 5501 5707 5708 5709 5700 5701 5702 5704 2155 5705 5682 5683 1020 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 9978 7314 6500 5687 5688 551 5689 8553 5936 28999 56938 1628 6256 85457 25819 79365 150094 5465 6095 6720 4297 1460 5187 1459 8864 1457 8863 1408 1407 1454 26224 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation 64135 1147 23586 84282 4790 57506 4792 351 4793 7706 7186 4791 5970 89122 3551 6285 8517 6288 7189 6283 3146 4214 28512 177 28511 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 96%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 2864 3670 2626 5122 28972 60559 5080 9789 139760 1803 2695 90701 23478 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME DATABASE ID RELEASE 96%5619055 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) 123041 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) 808 178 8908 5261 5236 5260 5255 2548 5834 5256 5836 5257 5837 2992 83592 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins 1511 2999 4311 290 1360 1359 10159 1636 5972 1522 1215 59272 1509 183 1361 1066 2028 REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation 23112 26523 57690 266743 192669 192670 27161 27327 4343 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 96%442755 Activation of NMDA receptors and postsynaptic events 808 2892 817 2890 818 107 57576 2893 84254 5923 5924 5566 6197 6196 28964 53632 5879 6714 4893 3265 6195 5594 5595 5567 5568 5562 5563 3084 5564 55327 5565 2891 5571 3838 114 2904 26960 5575 8825 4900 51422 10645 5573 88 22843 1740 2906 8573 9647 8536 2905 5170 5577 814 2903 4747 5613 2902 320 1742 27330 5576 116443 1741 116444 1739 64130 815 816 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development 4086 23462 4089 23314 865 25925 3280 4091 4094 1277 2737 2736 10413 121340 6714 632 7525 8841 10013 23493 3549 10432 25937 25 5594 5595 367 5925 9759 221044 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME%R-HSA-8964539.5 Glutamate and glutamine metabolism 65263 29920 5831 883 2806 4942 2746 27165 2747 2752 284716 57494 2744 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 96%70171 Glycolysis 23636 5903 9972 9631 7175 5519 11097 2646 23511 8086 8021 53371 80201 8480 10762 5515 5566 5516 5518 2821 2597 79902 3101 5528 226 83440 387712 229 2023 5230 7167 2027 2026 5567 5568 348995 230 5210 57122 5211 2645 5213 10007 669 26330 5207 55746 5208 5209 3099 5223 3098 5224 23279 79023 283209 6396 5214 5232 9883 129401 132789 9688 23225 4927 23165 55706 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation 5045 5499 28972 3312 60559 5500 3320 3326 3837 1460 9789 1459 1457 90701 23478 5501 7514 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME%R-HSA-9854907.3 Regulation of MITF-M dependent genes involved in metabolism 10891 23411 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 96%418890 Role of second messengers in netrin-1 signaling 7224 7223 57113 7225 5335 1630 9423 5306 7220 7222 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 54464 3842 7529 167227 55802 9261 5393 11340 22894 23016 23404 7538 51010 54512 51013 56915 118460 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 96%983231 Factors involved in megakaryocyte development and platelet production 5889 55619 80005 29127 55669 25942 9927 10019 85440 3660 10603 1794 1793 5879 9585 55083 23046 55605 113220 1017 3833 3066 3834 9732 90990 23095 64145 139818 10749 91768 55614 830 146909 7465 832 55582 23303 124602 64147 221458 829 547 998 3798 3799 57572 1062 3442 3065 3441 3440 5567 5568 3452 3451 3449 3448 3446 3021 3445 3444 3443 3043 2627 5868 7975 4097 8968 11311 23348 5575 5573 22920 653604 81930 5577 84643 3796 23028 5576 3717 64837 23468 26153 147700 10112 9493 3831 3832 3835 1020 5566 56992 24137 89953 11004 23414 8165 23186 9371 10362 51317 285643 3705 161882 10938 55604 3797 221037 25970 11216 3046 3045 81928 23764 3048 2625 3047 50808 2624 30846 30845 2623 64780 140628 2626 3456 4778 1795 11127 7157 3659 81704 25 5890 4602 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis 808 54205 6648 56652 11232 5442 2551 23410 84808 23408 2746 23082 6256 2747 5465 6742 55902 2101 7978 96764 4899 506 3418 6907 80205 3054 8648 10891 64216 7019 51106 10499 10498 79718 6604 4208 133522 4209 64784 8841 9611 9572 200186 1387 23373 23054 23409 1386 5469 814 85441 211 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs 4048 5743 240 246 3248 DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 96%5579019 Defective FMO3 causes TMAU 2328 KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization 337959 112802 337963 337960 728224 100505753 440051 440050 728255 100507608 387273 51350 192666 254950 387266 387267 728318 353288 25984 440021 125115 100505724 388818 83899 83895 83897 83896 100533177 9119 147183 338785 440023 284827 653240 84616 100131902 85291 85290 85293 386684 386683 386685 85294 85280 319101 374454 386680 386682 386681 386677 3849 386679 386678 386672 386675 57830 386674 342574 85289 3846 85285 3860 3858 3859 3850 3851 3852 3853 3854 3855 3856 3857 439915 100132476 3861 643803 3866 3868 3848 8502 823 826 64065 5045 5046 26085 404203 5266 4014 26239 6707 84648 353132 353131 6700 643414 11187 6701 6704 643418 6703 3713 6706 6705 643394 63036 353134 43847 23254 353133 43849 353135 7051 353137 353139 126638 199834 353141 2312 149018 353140 353143 353142 1825 1824 1823 6698 353145 353144 1041 7062 448835 2125 23581 1475 142910 6768 11005 5318 11202 147409 9333 1832 5493 1830 25818 5652 254910 1829 6699 1828 340654 5317 728279 3880 3881 286887 3882 353323 337879 100288323 83902 54474 337882 337880 81850 81851 3872 3875 643812 140807 3890 3891 3892 353332 353333 121391 83901 83900 3883 3884 3885 3886 3887 3888 3889 728299 162605 337979 337978 337977 337976 337975 100132386 81870 81871 81872 140258 196374 8688 8689 8687 337969 3728 337967 337966 337974 337973 337972 337971 337970 144501 390792 387264 CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER 375056 2890 1294 7039 5265 3998 4253 2153 2348 10175 1522 10972 374 51128 9554 9871 9632 1075 254263 10427 81562 2157 966 149111 10959 6811 10113 10802 90411 10484 9570 79748 10960 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation 4508 4509 64432 65003 64951 65005 65008 28977 90480 51081 7284 6150 55168 64949 28973 65080 51642 5018 54998 10573 11222 128308 51649 9553 64960 92259 63875 64963 64965 64968 55173 55052 64969 51373 4512 26284 4513 51650 4514 60488 51253 51258 219927 29074 10102 56945 64975 28998 64976 79590 64979 64978 23107 28957 64928 7818 57129 51263 29088 51021 54534 51023 51264 51069 84545 85476 78988 4519 122704 65993 64981 10240 64983 3396 26589 63931 6182 54460 6183 118487 51073 4706 116540 740 54516 124995 9617 54148 84340 116541 4540 55037 29093 4541 9801 4535 54471 4536 51116 10884 4537 54948 4538 51318 4539 91574 92399 123263 4528 219402 51250 115416 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 96%202670 ERKs are inactivated 1849 1848 1846 5519 1845 5515 5516 5518 5594 5595 5598 5528 51231 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020933 Interleukin-23 signaling 6775 149233 5034 3594 3593 7297 3717 6774 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere 1616 546 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 96%1810476 RIP-mediated NFkB activation via ZBP1 5970 1147 7098 3551 8517 4790 4792 148022 4793 8737 28512 11035 81030 28511 1660 4791 4615 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 96%3371497 HSP90 chaperone cycle for SHRs 55860 51164 4306 10671 93661 3304 84516 140735 10728 3312 55466 3301 3320 3326 3306 10294 3305 51143 10121 1639 11258 1781 5241 1780 830 832 1778 3337 2289 367 10963 829 10540 2908 2288 8655 1783 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins 5708 5709 5700 51529 5701 7321 5702 5704 8881 64682 5705 25906 11065 5682 8697 5683 7324 5684 10393 29945 27338 5685 119504 9212 6790 5686 29882 5717 891 5718 246184 5719 983 996 8945 11047 51434 5713 51433 5347 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 6500 890 5687 5688 5689 1017 51343 6502 5925 9184 991 8900 4085 4751 701 26271 8556 9861 8454 9232 6233 7316 10213 5706 5707 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 96%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs 22868 9238 60493 NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 96%927802 Nonsense-Mediated Decay (NMD) 6230 6231 6234 9349 6235 6191 6193 6192 6194 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 23049 6158 23293 9887 2197 55181 23521 23381 55629 140032 56006 5520 6164 6166 6165 6168 6201 6167 23708 6203 6169 6202 116832 6160 6161 2107 55802 26986 6175 9045 2935 6210 6176 6171 6170 6173 51065 26019 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 6222 22916 6224 6181 6218 6217 4686 65110 5515 5518 7311 22794 1981 9939 65109 9775 10921 55110 4116 5976 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 55970 2793 2792 2791 2790 2788 2787 5058 2782 2786 54331 2785 59345 2784 2783 10681 998 51764 94235 9459 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669936 Sorafenib-resistant KIT mutants 3815 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors 1655 6613 10401 10210 10155 57332 8535 2033 25942 28996 8648 9994 7703 115426 10891 57591 7690 648 10499 6015 4869 10521 1912 1911 8204 4152 7341 80012 59348 84733 6294 1616 1487 1387 8554 3622 9612 6045 51588 6612 11315 7329 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 96%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) 6521 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 96%1474228 Degradation of the extracellular matrix 91522 11131 3911 1297 23473 3912 11132 4317 4312 4319 5654 4324 4811 4326 4327 7177 1305 85007 1303 6650 147968 26254 50859 1308 1307 84570 1306 388743 1215 80274 63827 8754 1634 3817 64386 101 999 1991 5663 2 4316 23385 5645 4323 4314 4325 7077 7076 5340 4318 1511 1520 1508 7093 7092 649 1509 4313 5644 3818 84290 1504 440387 831 823 960 824 826 176 5045 3339 1514 1513 836 1515 6696 682 9510 4322 9507 102 10893 6868 92291 10753 56999 222663 825 827 80781 440854 8751 11096 3914 9313 11095 3915 1299 726 1310 3918 1298 170690 5650 170692 7373 4320 4321 3909 136227 164656 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism 4860 100 3251 353 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels 55970 3760 3761 2550 3759 3772 54331 59345 3762 3763 3765 3766 3768 2793 2792 2791 3773 2790 2788 2787 2782 2786 2785 2784 2783 10681 51764 94235 9568 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS 51000 9061 9060 284129 1836 10861 347734 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 2053 1573 1545 1558 1559 1557 1544 1543 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions 1572 1571 1549 1548 1558 1559 1557 1555 1565 1553 29785 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling 6093 10552 3984 3985 10093 71 10092 10095 10094 9475 5921 10097 7074 10096 60 8997 2904 6453 5747 4067 5879 387 7525 3265 5058 1072 2902 6383 10109 2534 64283 998 8976 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 54107 10980 7874 9318 50813 2067 10920 6917 2873 7507 51138 3978 2074 10987 7311 9978 7314 56949 1161 5440 5441 4331 1022 2071 2966 2965 2068 9716 5434 3980 5435 5436 5437 5981 7515 5438 5982 5439 5983 2968 2967 91603 404672 56655 5430 57654 5431 5432 5433 902 8451 8450 5111 1642 6117 5984 5985 5424 6119 5425 10450 6118 5426 5427 10714 27339 51426 57804 6233 7316 8533 2073 8178 57461 2072 64708 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport 344 26020 345 6382 57016 2719 151056 54884 51109 221914 9672 5950 9227 2239 5948 348 83875 338328 335 5406 7804 5947 338 1208 29967 3339 4023 1645 1109 2262 7276 336 337 53630 55937 2817 4036 6383 10082 6385 375790 4035 8644 3949 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 96%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation 2353 841 7186 8767 4615 4791 57162 84166 4205 10454 7334 6285 7335 929 6288 11274 7189 64127 353376 6283 148022 3146 51295 257397 51135 9261 4214 23118 9683 9684 6195 1432 10392 28512 79155 57161 79671 5594 177 5595 121457 246330 28511 3656 9097 466 5600 51231 1849 7867 1848 1846 1845 5604 23643 4208 51284 7099 1386 8454 6233 7316 1326 6885 23291 80216 92610 1147 5519 4790 351 4792 5515 6197 6196 4793 5516 5518 8945 3725 3654 5528 7311 5970 7314 6500 3551 8517 5608 5609 6416 5601 5602 5606 5598 2002 5599 7157 9252 54106 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 1616 546 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-HSA-76005.4 Response to elevated platelet cytosolic Ca2+ 5099 5267 350 94121 8407 12 5155 1 51097 23052 9749 135228 54495 5196 813 5175 7114 3671 66005 7040 6814 6813 226 7123 29106 83706 10184 51571 967 7422 5874 3699 6810 7273 54863 2 81 5768 7044 22915 10490 2621 29789 197 213 51368 5552 22927 2162 1072 2277 3309 7042 10916 5627 6403 7078 7873 3273 1521 6414 7076 308 948 3700 5340 5341 5345 3959 54676 1893 259215 78991 7043 6678 9948 139322 6694 7424 5004 7423 334 5919 55664 3481 374354 3479 10447 5005 27154 335 2316 51706 3827 5578 5054 88 1675 6647 5579 10257 2244 2266 10487 7414 808 5216 5478 7450 3690 2243 7094 351 5265 2153 87 7057 2157 5660 3674 5473 710 928 7018 1191 1950 7277 3082 5582 2335 3920 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME%R-HSA-9924644.2 Developmental Lineages of the Mammary Gland 374 7039 2255 1950 5617 ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 96%9010642 ROBO receptors bind AKAP5 5532 6092 5567 5568 5576 9495 5566 5578 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602410 TLR3 deficiency - HSE 7098 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 96%9614657 FOXO-mediated transcription of cell death genes 65018 6794 2308 10018 604 2033 356 1387 27113 1649 4303 2309 4800 4801 4802 10370 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters 5172 1811 284129 1836 65010 10861 115019 115111 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 96%5669034 TNFs bind their physiological receptors 10673 23495 7132 7293 7133 7292 60401 8784 8600 9966 356 128178 8718 8740 8744 8771 939 943 944 970 4049 10913 1896 8764 3604 8741 4982 608 8995 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 96%168164 Toll Like Receptor 3 (TLR3) Cascade 7321 2353 841 8737 329 11035 7186 8767 4791 330 7322 84166 4205 10454 7334 6285 7335 6288 7187 11274 9641 7189 64127 6283 148022 3146 257397 10010 9261 10133 23118 9683 9684 6195 1432 10392 28512 79155 79671 5594 177 5595 121457 28511 3656 9097 466 5600 51231 1849 7867 1848 1846 1845 5604 7098 4208 1386 8454 6233 7316 1326 6885 23291 80216 92610 1147 5519 3665 4790 351 4792 5515 6197 6196 4793 5516 5518 8945 3725 3654 5528 7311 5970 7314 6500 3551 8517 5608 5609 6416 5601 5602 5606 5598 2002 5599 29110 3661 7323 7157 9252 8772 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 96%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 8452 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 1460 1459 11047 1457 5713 5714 7979 8405 5690 5691 5692 5693 5694 7311 5695 9978 7314 5687 5688 1019 7532 595 5689 29126 9861 6233 7316 10213 5706 5707 SIGNALING BY MAPK MUTANTS%REACTOME%R-HSA-9652817.2 Signaling by MAPK mutants 1849 1848 5594 1852 80824 1850 11221 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 96%9706374 FLT3 signaling through SRC family kinases 3932 3055 2323 2322 2534 6850 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) 6569 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) 338567 ADENOSINE P1 RECEPTORS%REACTOME%R-HSA-417973.3 Adenosine P1 receptors 134 135 136 140 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%8851907 MET activates PI3K AKT signaling 5290 2549 3082 4233 5295 NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism 954 955 956 9615 4860 377841 22978 25939 10591 57089 3704 4907 7498 55270 56985 131870 11164 56953 953 7378 1807 151531 1890 1806 957 51733 84618 64902 93034 30833 9583 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%392154 Nitric oxide stimulates guanylate cyclase 5593 4842 5152 10242 5138 10335 4843 3708 2983 2982 2977 27094 3778 3779 4846 10846 5153 27345 50940 5136 8654 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition 5054 1000 10085 3673 999 6935 727936 6657 201595 7837 5829 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 5888 80010 5889 7486 472 672 675 83990 7516 5932 9156 7979 641 79728 116028 10635 10111 4361 7156 5890 5892 4683 580 10524 1763 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME%R-HSA-9909505.2 Modulation of host responses by IFN-stimulated genes 64135 1147 3551 23586 10964 8517 51191 22926 2537 25820 9451 7706 9246 2289 3309 3429 7318 9636 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME DATABASE ID RELEASE 96%5658208 Defective SLC5A2 causes renal glucosuria (GLYS1) 6524 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610783 Degradation of GLI2 by the proteasome 5708 5709 5700 5701 5567 5702 5704 5568 5705 5682 5683 5566 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 2736 5690 5691 5692 5693 5694 7311 5695 9978 7314 6500 5687 1452 5688 2932 5689 9861 8454 6233 7316 10213 5706 51684 5707 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-HSA-5654716.3 Downstream signaling of activated FGFR4 9965 4893 6654 2254 3265 5781 2251 5295 8074 2249 2247 10817 5290 2246 152831 5335 8823 2549 2264 10818 8817 26281 CELL DIVISION%REACTOME%R-HSA-68884.6 cell division 23047 10112 9493 23063 10274 25836 23244 23383 8243 10735 9126 5885 5347 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation 7518 8815 7520 3159 3981 2547 11168 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME DATABASE ID RELEASE 96%5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) 9990 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME%R-HSA-5609978.5 Defective GALT can cause GALCT 2592 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation 22916 4686 6827 6749 4298 6830 27125 55840 4300 85403 9150 55677 6917 1025 51497 11198 8812 23168 79577 25920 80349 51224 6921 123169 6924 7936 9646 6923 7469 904 905 54623 5440 5441 4331 1022 2071 6829 2966 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 8178 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-HSA-983695.6 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 808 695 930 6786 10768 640 3708 3709 29760 973 118788 974 7220 4067 3710 30011 80228 6654 7409 5295 4690 933 84876 5336 5293 2534 27071 5777 6850 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis 8331 8337 5888 8334 5889 8335 4001 10274 8341 8342 8347 26277 8348 8243 8345 25913 8340 5885 8338 85236 8349 4292 1019 1017 54386 8370 8290 7013 65057 7014 7329 3013 255626 472 672 675 56979 3021 3018 3017 3014 5932 9126 3306 9985 27127 474382 10734 50511 641 93426 55732 8970 10388 128312 6117 23345 23224 11144 256126 23626 56158 25777 94239 6119 6847 29893 55766 644186 27030 23353 84057 6118 4438 8968 4439 653604 8468 10111 10735 4361 7156 54145 4683 63979 545 PROTEIN HYDROXYLATION%REACTOME%R-HSA-9629569.1 Protein hydroxylation 6194 79831 84864 6228 11338 2107 79697 51389 1819 6157 100137047 23210 55239 444 55854 6132 2158 4733 65094 91433 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface 475 6556 538 51248 PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation 808 107 5567 108 109 5568 5575 5566 5573 111 112 113 5577 114 115 5576 26960 196883 DEFECTIVE CYP21A2 CAUSES AH3%REACTOME DATABASE ID RELEASE 96%5579021 Defective CYP21A2 causes AH3 1589 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 96%8849468 PTK6 Regulates Proteins Involved in RNA Processing 6421 10657 10656 5753 202559 INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-HSA-8981607.3 Intracellular oxygen transport 4151 58157 114757 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%169911 Regulation of Apoptosis 5708 5709 5700 5701 5702 5704 5062 5705 5682 5683 5684 5685 5686 5717 5718 5719 79658 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 4976 5687 115209 5688 5689 9861 6233 7316 10213 5706 5707 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) 83795 89822 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 96%5683371 Defective ABCB6 causes MCOPCB7 10058 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins 3276 100128731 7311 7314 6185 6184 2932 746 1603 7341 7329 821 84061 11282 7841 29801 6733 2589 25921 6732 253832 54956 51201 7991 143 55741 2931 11320 56965 51125 83666 201595 4247 79668 84875 51304 3703 4249 54625 10610 6483 6482 6484 6487 4245 1650 4124 6480 25834 1452 23193 256435 79844 2530 27090 11253 5589 51114 6233 7316 58505 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 96%192823 Viral mRNA Translation 6222 6224 6181 6218 6217 6230 6231 6234 9349 6235 6191 6193 7311 6192 6194 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 5611 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 2926 6209 6208 6188 6187 6223 6189 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 96%2173782 Binding and Uptake of Ligands by Scavenger Receptors 2495 948 5052 6678 3320 3043 1278 10525 3040 1277 348 335 338 286133 3512 8685 259 4481 3263 8542 117156 3240 81035 3250 8578 55576 922 284297 6288 7184 10808 3146 1284 1282 213 78989 1281 23166 6280 2512 5648 811 9332 4035 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 96%5687613 Diseases associated with surfactant metabolism 6440 729238 653509 6441 1439 1438 21 6439 10568 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5654726.4 Negative regulation of FGFR1 signaling 5515 5516 5518 10253 8569 3730 7311 7314 867 2254 5781 2251 27006 8074 673 2249 2248 2247 2246 6233 5594 7316 5595 2255 10818 26281 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 6500 890 5687 5688 1019 595 5689 1017 898 6502 9134 1027 1026 1163 5753 8900 9861 8454 6233 7316 10213 5706 5707 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling 10276 9138 727 388 718 11214 128272 26230 29 121512 84904 100271715 25791 89846 6915 54848 22899 50649 5364 8874 64857 2768 57449 389337 445328 2245 221472 55701 10672 9459 146 389 147 148 146850 9287 3363 3362 998 3361 3360 59340 153 2652 154 155 3358 3357 3356 1133 5567 3355 5568 1816 83551 1815 1814 1812 134864 319100 134860 57105 9038 1132 111 3354 1131 112 3352 113 3274 114 3351 115 1129 1128 10000 3269 4935 136 23533 346562 5575 207 10800 208 7409 8503 814 5577 5613 719 196883 2771 2770 695 2781 2773 107 108 109 4986 4988 5332 3678 9630 6000 8787 2550 8786 9628 26960 2767 2769 6750 10645 2776 5582 23229 9568 2774 84254 5924 6010 2779 6288 5533 3838 6753 5578 5330 5331 2780 23236 5573 5579 1956 2847 7222 7225 387 23370 611 57113 7204 57580 1234 4852 26084 3688 8997 6453 7984 23263 6714 4893 5588 4168 6654 10235 27237 3265 6195 5594 5595 1908 1906 5443 4157 11343 1910 5499 4161 4160 4159 1524 7252 1081 6387 7410 51083 7852 729230 10451 1230 10663 56670 338398 5576 1237 1236 6655 1235 5534 1233 1232 808 170589 4985 4987 5530 6093 5956 5532 10125 5729 27198 27199 5726 5739 2587 1020 5732 4886 351 5733 9475 5734 4887 10850 4889 2359 1269 2357 1268 259289 2492 259287 259286 259285 3579 3577 2488 56477 5995 4543 4544 259294 259293 259292 259290 5741 259296 2793 259295 2792 353164 2791 5660 2790 6751 5540 6752 9340 5539 2788 338442 2787 643 796 2786 6755 6754 301 8811 797 2785 151306 116 2784 8843 5697 2740 256933 117 799 2783 54429 80835 51764 80834 94235 3375 10692 1839 1394 9934 5473 1392 8862 55970 113091 79924 4283 10266 6346 5744 4158 5745 5368 10268 10563 5746 6351 10267 6352 6357 2692 2691 5030 133 54331 6364 6363 53829 59345 6366 2642 2641 6360 1903 6373 6372 6374 6376 6370 134 135 5173 5179 7433 6344 150 140 151 152 5140 58191 7432 8698 6343 7253 2919 2918 2917 7434 2916 2914 53637 2913 2782 2912 2921 2920 221391 2778 8484 11251 2696 23596 2695 186 187 10681 83756 165140 50831 50833 10203 50832 2826 50835 50834 50837 50836 50839 50838 2833 4295 2832 7200 2831 7201 122876 431704 50840 56413 1880 5031 57007 5032 283869 6003 2841 1909 6004 2853 94233 2852 2798 10803 2797 2796 50865 1907 5028 5196 2861 84432 5029 64805 1902 9283 6375 3972 1241 3973 2693 9290 84109 9294 10874 1325 29933 222545 3627 10887 5724 10886 257313 5731 5737 64407 387129 2911 2358 846 2915 8111 8477 2922 5996 5997 5998 5999 6846 2925 10161 6863 183 185 623 624 4314 10287 1395 56923 6870 8490 2151 23566 2150 2149 2147 6865 2829 2828 6866 6869 353299 885 886 887 2837 347148 9002 57121 338557 5580 5321 3814 156 10911 5137 2840 5153 2846 594857 5136 64106 3827 129521 128674 2867 2865 2864 2863 3710 2862 60675 4922 4923 2869 8620 680 27334 84634 3060 5367 23620 3062 3061 10316 4828 4829 26575 2520 9170 84539 815 816 817 818 5519 10768 3708 3709 5515 5566 408 6197 5516 409 6196 5518 5528 5020 551 5021 552 553 554 5598 3576 5581 5583 7074 9162 8527 26090 728 8525 8526 57406 221955 10636 160851 10888 1609 26086 747 10846 1608 50940 1607 84152 1606 85397 139189 8601 126006 51289 3640 8622 10022 5141 122042 5143 5144 117579 5138 6019 339403 5139 5151 59350 6001 6002 5150 53831 9560 55160 11245 23365 11250 115557 285601 9181 26166 5294 2838 5295 157 2843 5296 2848 1894 5058 29899 27115 5290 2854 5170 2850 2870 63940 9826 9828 50650 9639 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine 51005 64841 5238 55577 2673 6675 9945 5973 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-HSA-5656169.2 Termination of translesion DNA synthesis 54107 5981 5982 5983 56655 9100 7706 11201 51455 9768 124739 9246 5111 7318 6117 5984 7311 5985 5424 6119 7314 5425 6118 5426 5427 5429 10714 51426 57804 6233 7316 9636 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation 7874 1107 53615 192670 27161 23608 26523 1108 2475 10273 331 23112 5728 57690 3066 192669 6591 4734 5594 5595 2146 5978 57504 9112 4343 3065 2122 64223 57459 10000 27327 54815 8726 51564 8841 207 208 1386 9861 6233 23512 7316 5928 23028 10213 5706 6615 5707 5708 5709 5700 5701 5702 5704 5705 11060 5682 5683 8975 81847 80243 5684 23252 8535 5685 5987 8658 80351 5686 5717 2444 23186 5718 5719 11047 5713 5714 9219 7979 3725 5690 5691 5692 5693 648 5694 7311 5695 6015 7314 5687 5688 1912 1911 5689 80012 55004 8649 84733 64121 58528 10542 6045 389541 28956 57521 10670 6009 5468 153129 10325 23466 5371 57332 1460 1459 1457 5931 7157 1958 10014 7101 57167 1822 84232 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 96%5632968 Defective Mismatch Repair Associated With MSH6 4436 2956 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking 857 115677 1785 4846 8976 HATS ACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%3214847 HATs acetylate histones 8331 8607 8337 440689 8334 8335 93624 8341 8342 8347 8348 8345 10445 8340 8473 23326 23774 64769 8338 85236 8349 51230 86 8370 6314 5077 3013 10856 255626 3018 2033 3017 27154 3054 8648 8970 317772 128312 92815 79595 85235 8969 10499 221613 8295 55167 8968 10933 23338 10943 9575 27097 56943 55578 9767 9643 9913 51147 653604 23522 117143 1387 8089 54556 56970 11091 11143 1386 6944 8464 55929 55250 79960 10902 55257 10629 339287 26610 23587 55140 54859 8520 8518 7994 6881 6880 6883 8850 57634 6871 55683 55689 284058 80314 54934 10474 60 1810 51562 26009 5931 112869 57325 84148 2648 84289 7862 10524 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 96%6811555 PI5P Regulates TP53 Acetylation 2033 7157 3622 90809 5608 8396 5305 5300 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 96%4839744 Signaling by APC mutants 5519 1452 139285 2932 5515 324 5516 5518 8312 5525 5526 5527 5528 5529 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM 10568 COX REACTIONS%REACTOME DATABASE ID RELEASE 96%140180 COX reactions 5742 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3645790.4 TGFBR2 Kinase Domain Mutants in Cancer 7046 7048 7040 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 96%3371511 HSF1 activation 7415 3320 6119 3326 3297 1915 6118 7531 10728 6117 10013 3281 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) 6005 METABOLISM%REACTOME%R-HSA-1430728.16 Metabolism 6555 6554 200931 123264 10998 80765 117145 26230 6697 57107 56997 56910 2644 2643 84842 79934 51004 51805 57017 5805 23590 10229 27235 51117 84274 26063 1962 122970 215 340481 11001 3295 30 10005 54659 146850 7084 93034 9583 471 790 158 159 954 955 956 9615 5471 5198 8226 377841 5563 7372 7371 83549 54963 5565 22978 10591 57089 122622 978 1723 3704 1131 10606 2618 10331 23533 207 8503 23169 10 9 10941 133688 54490 79799 55347 54658 54657 7358 7363 7365 7364 7367 7366 54600 54578 54577 54576 54575 574537 54579 167127 10720 5730 10390 9468 1120 162466 10809 56994 1119 5130 84879 171586 58488 10400 23576 114757 80777 10434 6610 55512 7274 2629 9630 27068 2767 26330 2769 7157 10249 123876 341392 219970 92292 54988 389396 2776 8877 9883 6534 129401 9688 291 23225 4927 7263 25828 23165 23179 58472 100131187 55706 23636 23743 9972 51380 4507 9631 2326 7175 1036 11097 23511 875 58478 8086 6821 8021 635 53371 84245 8480 2806 10762 2805 23474 339896 1491 51074 55256 1468 4357 84890 6609 6230 9600 6231 1040 6234 57605 9349 83394 6235 10423 6191 6193 6192 55289 6194 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 51102 3921 4736 6130 6133 6132 7352 6135 7351 6134 9016 6137 9481 6136 6128 4051 4363 6129 11283 6142 6141 22949 126410 6144 1580 6143 241 6146 57834 6147 246 284541 6139 6138 6152 6155 6154 6157 6156 6159 6158 3320 2197 23521 3837 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 5901 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6207 6206 6209 6208 6188 6187 6223 6189 6222 6224 6181 6218 6217 8034 8875 8876 5167 5168 8884 5169 2194 80025 284439 254552 80347 53354 79877 79646 60496 55229 79717 51248 60490 8399 374986 5320 137964 9218 5322 26279 283748 201164 6901 81579 5827 84803 55326 80821 56894 56895 51205 5338 10554 253558 5319 10555 8443 22925 3421 200879 64600 29090 23259 23171 100137049 84895 254531 79888 149998 2819 30814 9397 50 90639 51085 79602 10063 9370 51094 427 1431 4714 9673 36 586 587 27034 11112 4329 123 2350 2109 4836 51520 683 1615 5859 6296 35 4141 1892 3033 142827 3376 7965 9521 5443 5917 3735 9255 2058 5868 7252 50506 53905 760 405753 762 51061 1081 7173 1734 1733 389434 857 759 90527 6528 1735 7498 55270 2653 3251 7172 3615 2944 3614 2987 4830 2939 4831 26251 8833 10057 2938 3790 3326 3745 3747 6794 5230 37 95 6844 6616 6804 3638 51360 2224 2222 3157 6667 51128 4706 4800 4801 4802 6309 10654 4540 9871 4541 9632 4535 57678 4536 10427 6713 4537 4538 6319 22937 4597 79071 8895 51141 51365 1595 56261 6721 63874 1717 57110 31 27132 283871 32 64850 9453 9489 4047 4520 9362 55500 8720 114971 10802 55224 3422 5833 4598 154141 10484 9926 7108 23761 54675 347516 23659 114884 80339 117245 8904 54979 8760 8574 114879 114882 22977 85465 124975 5920 2686 91703 4257 4258 4259 246181 54205 6584 27109 4508 4509 498 3313 513 183 514 5096 515 4594 84693 516 166785 517 5095 539 443 518 2346 10476 10632 339983 10003 9551 374569 9556 84833 326625 27249 25974 521 522 4899 506 509 2864 3710 1591 25902 6470 83594 55328 23057 160428 2694 8566 200895 60386 441024 952 4522 4524 6947 3767 54 160728 80308 29914 23475 79581 128240 1743 54981 4967 55034 64087 5644 10840 152926 55163 26275 154807 549 79001 56922 27010 3712 4338 10768 55739 1504 3708 3709 349565 133686 55065 5566 285362 3141 55191 440387 27231 8460 10243 79642 79178 316 92014 80704 7295 9390 25870 93100 64802 51293 8459 686 10588 65220 340075 6573 113278 27304 81034 10797 410 412 55312 10560 64077 5464 414 415 416 22901 153642 347527 120227 15 121278 438 5335 5286 8824 23396 8871 4036 5743 240 6833 79751 83733 8402 8604 10165 4190 4191 85007 248 5406 1208 5264 1384 23600 283927 1610 54677 390916 8528 8540 54363 51179 8310 373156 2053 570 55825 51268 120103 8309 6342 10965 189 196743 26061 6583 6520 8140 55588 6539 80306 6483 6482 6484 6487 9412 400569 3630 55090 23097 6837 81857 4512 219541 4513 4514 2593 54797 2101 28976 4728 4729 4720 4723 4725 6720 4726 25915 55572 4731 152100 93058 1024 100996939 3420 116228 28958 55101 23389 51300 84701 1353 374291 3419 3418 6389 55471 80775 54949 2110 119559 6391 6390 6392 2108 122961 51204 285521 6834 84233 80219 25880 80224 51103 389203 284184 4694 4695 4696 2271 79133 57226 51241 126328 8802 10131 8803 55967 239 405 8801 55969 6515 10025 54928 81689 6783 57001 10380 644096 391365 84987 25830 100303755 6818 55744 6817 892 55863 84836 54539 6819 91942 90871 27284 23530 445329 3052 27233 6799 29078 100131801 50512 137682 6822 192286 341947 751071 4705 4707 4708 10001 4709 135154 4700 4701 4702 4704 6341 25942 79064 4716 493753 4717 4718 4719 51079 4710 4711 4712 4713 29079 4715 5467 3081 6898 3242 2184 10858 1594 1584 51302 5447 5783 9612 9862 948 376497 4199 1728 2940 84246 2950 644 50484 645 9443 2729 9441 9442 2730 8714 2876 9440 51586 9439 728294 79944 137872 2821 9477 7296 112950 25979 8396 1514 23408 2746 2747 2638 3930 1586 6715 6716 2877 2874 9282 2645 113675 10993 10247 51447 1327 1329 1340 1337 1339 1351 1350 1349 1347 1346 1345 25939 5728 125965 221 27165 5867 8398 129642 255043 8605 11145 10162 123745 79887 8560 255189 50640 50487 151056 54947 11010 613227 2717 80142 51003 2760 10135 94103 7298 4697 7083 1719 5305 9915 79777 3291 3290 866 501 55349 29958 1757 2328 2327 91012 23683 25865 142891 5660 340485 53947 9514 23410 29956 55331 388931 166929 165679 125981 79152 9517 55627 8706 5105 7357 2583 204219 2581 253782 171546 29095 56848 8611 8612 7368 5587 339221 57704 130367 123099 259230 124976 56624 79603 8613 94101 10558 55304 10715 151742 64781 81537 57733 222 2531 348 8879 5007 9968 9969 26031 9885 9023 3294 51171 51170 441282 114880 114881 114883 4082 253430 9562 6241 6945 6861 9997 6257 8424 123688 57515 55217 65263 125061 29920 5831 8564 262 169355 384 5723 275 51686 548596 23498 113451 1160 51582 10955 1158 6723 10157 347735 6611 79814 8942 56267 6999 284716 89874 57494 3972 112817 2731 83884 6535 9380 63826 256987 51166 6303 55526 90809 2628 619189 2639 1428 130013 29968 4947 4942 4946 26227 223 3620 4953 776 90390 5053 883 259307 5860 5092 80150 9377 9110 2744 133522 9167 2539 2538 27063 158584 1376 1375 58526 5742 284486 80221 145482 8826 2274 873 2166 79094 55856 5444 26873 84188 2098 653689 788 5445 27306 5446 2941 79017 11332 345275 55748 2949 80724 3248 2948 10449 2947 84320 4048 247 1572 2946 1571 414149 221357 64816 2954 29923 9536 2953 57491 84129 2952 196 161247 1558 494143 119391 1557 50486 1577 127281 1555 128486 1544 22 23597 1565 64210 55711 1543 4682 27242 1576 641371 9391 64428 134526 1553 29785 158833 57019 1562 27158 1622 1573 10101 27349 1551 51647 26027 29841 54905 1549 1548 1559 48 3163 9429 6548 25994 768 594 10295 1629 1738 593 11069 10411 26119 338328 81693 51129 10062 4023 8029 19 116519 23491 213 336 337 3949 344 345 5567 5568 3417 5261 10090 8534 23729 64711 9061 9060 222537 337876 230 5260 2548 231 4969 27087 51084 29940 2542 10894 83592 6120 2683 4129 3099 3098 54480 115677 4060 55454 2799 55576 30815 56548 22856 11041 729020 28 11285 2331 378884 2203 6007 60495 6006 8789 11046 5834 5836 5837 9653 6383 10082 6385 2584 2582 130589 54020 6382 124872 134147 10402 81894 11261 670 2592 218 8692 761 7360 80201 763 765 10855 766 2588 3795 11238 221914 2052 771 9672 314 5631 9435 23632 8639 25796 166012 13 51218 2239 874 960 51312 284129 2597 4835 64080 377677 10861 54996 5507 51070 221823 64757 440 22934 132158 3101 2132 2131 3340 387712 176 3339 178 8908 5634 1836 4669 347734 9334 9331 2023 2262 5091 26503 79586 55276 2137 3906 2135 57214 2817 8647 7167 9469 9348 5826 23563 90161 23324 2027 51363 2026 51000 10599 26035 7957 92579 79369 6513 2719 5549 6652 92126 64579 5244 126792 55788 80146 28234 55501 8703 8704 6888 8702 9917 8707 8708 8705 266722 5210 5211 4123 5213 10007 669 57818 5207 5208 5209 9942 5223 5224 10690 3161 7086 283209 3038 3037 3036 4125 5214 113189 4126 50515 5232 9953 9951 92370 26007 132789 9394 2998 2997 2632 2992 6677 5226 5106 375790 11081 64131 64132 93010 51181 2526 2646 10678 2525 2524 25961 79077 2523 10317 1635 216 2745 56474 9957 5236 102157402 9955 6240 6448 51727 122481 9956 8509 1503 2529 1841 203 2528 204 135152 221264 2527 26289 5255 205 4166 5256 4832 5257 4833 10201 26229 158067 55790 51071 4958 10327 226 83440 229 124 125 84532 126 56953 127 7378 128 217 1807 151531 55902 219 1890 130 1806 51733 131 84618 64902 30833 8644 7350 1149 1592 83401 161823 4860 270 271 272 56603 51292 340665 132 51109 100 353 2766 1633 1716 23646 54956 143 56965 83666 79668 84875 54625 5578 9049 5593 5330 5331 23236 4128 5573 9962 9963 1727 1528 58510 8659 5625 84002 5018 7416 55300 5297 8898 92259 22908 6305 10478 1583 51552 23760 56623 6472 26 144193 57571 5337 4722 3067 3034 131669 3954 3176 138199 10841 66002 6916 5740 1582 6770 4698 147323 83930 10948 706 134429 9217 9663 8694 392636 2173 2172 2171 2170 80168 84649 2820 116255 2169 2168 150379 2167 84498 346606 9967 8228 11343 646486 3991 5499 64900 646480 2713 2712 2710 51099 150763 23175 5500 5346 10226 1589 1585 3284 3283 3028 5576 9495 29906 7166 81849 5476 79644 10825 8869 4758 4759 5409 7054 1644 1621 4074 375 775 1785 4143 4144 4552 9446 191 4837 1312 29104 27430 57412 51504 4548 150 152 5289 6579 5162 5163 5164 5165 5166 64795 23409 4750 64777 30849 8050 160287 81889 92483 5160 5161 57546 55066 1244 3939 79018 51660 54994 10296 10873 1737 347411 4200 4289 25874 25852 3948 80232 2875 2739 3945 54704 7276 5646 1066 8897 8776 9107 55361 81846 22874 22876 84725 57664 54477 51763 3631 126282 8821 7179 65977 59339 59338 51573 55697 9108 4534 55613 133121 80230 66036 284161 375775 5287 5288 93492 10908 8394 79153 8395 64419 54893 377 25816 5298 9896 388121 200576 660 81544 54545 79626 170685 23262 11163 9677 11165 64768 55190 9807 117283 6812 242 59344 2879 2937 1152 4952 6514 403313 1718 6307 50814 91452 39 64801 10682 51478 91734 4056 111 112 113 114 115 2678 64174 4907 2687 5575 1800 953 5577 5336 957 8976 196883 2771 2770 107 108 109 34 1666 1632 23007 27124 8867 3633 3635 3636 9651 5332 5333 113026 84812 3705 3706 51196 3707 89869 122618 80271 148811 57104 8800 60481 7069 63924 2180 9971 9420 1593 1581 1646 6718 1645 80270 1109 6948 7389 5498 1352 3145 7390 1371 210 211 212 2235 1355 79966 51295 1374 285440 5950 5948 55750 5947 9861 6233 7316 10213 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 7804 5691 5692 5693 5694 7311 5695 7314 5687 5688 5689 116285 348158 7376 6256 7421 5465 6095 51588 5468 7329 6613 54884 83990 5424 3292 4035 51750 9261 56985 131870 11164 5906 162417 445 435 1373 10166 5009 57407 383 96764 113235 2033 3162 6907 80205 335 8648 338 10891 4862 10499 10498 79718 6604 9575 8841 9611 9572 1387 23054 1579 53630 55937 1545 5469 113612 8529 85441 406 8202 808 10728 9227 83875 126969 204962 158835 80736 57153 23446 2793 2792 2791 2790 2788 2787 2786 2785 2784 2740 2783 51764 94235 26020 10048 55970 57016 33 3032 3030 54331 590 1103 59345 43 2642 2641 29967 773 777 9256 9254 783 784 2782 6538 9200 47 9524 2752 2778 64834 401494 23205 23305 79993 10681 84869 253017 201562 51144 55301 11000 54898 5538 197322 51703 6785 22880 9374 2182 3293 81616 2181 51495 7923 109703458 79143 1462 2990 23553 3373 8372 55586 112937 64064 3074 3613 56898 3073 3612 79611 51477 63827 3632 1634 54511 38 3425 3628 79411 3158 65985 2720 622 411 3423 3155 633 5019 1464 51151 1463 4948 7299 89944 10675 7306 1638 6232 1455 348995 5321 57122 55746 23279 79023 5641 6396 4846 5501 5903 5519 5515 5516 5518 114876 9415 3992 79902 5528 9791 81490 7385 7384 7386 2068 440957 7388 440567 2395 7381 728568 55245 10975 57128 4519 1588 27089 29796 90624 84300 617 150274 112812 2232 54902 790955 2230 1537 1460 1459 1457 57761 51422 5294 5295 5296 5290 5291 5293 11185 118672 22928 51091 51540 6301 27232 60678 79048 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 96%9759476 Regulation of Homotypic Cell-Cell Adhesion 8331 8337 8334 8335 100128731 192670 27161 8341 8342 8347 8348 8345 3170 26523 8340 9314 51129 8338 2060 79872 1500 85236 1499 8349 54971 999 6185 23112 6184 6714 57690 3066 192669 746 1603 6591 26508 8370 5594 5595 5925 2146 6597 4343 3013 3065 255626 117581 821 3021 8289 3018 6663 3017 7841 3014 474382 90701 3703 8970 128312 27327 387893 55766 1650 8726 8968 1520 23193 1508 28972 5589 23411 653604 2294 9861 56978 8728 6233 64403 23512 7316 1495 27319 5928 23028 23478 80332 1006 10213 3224 5706 3609 7020 7414 6615 5707 1009 7764 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 27085 5719 6929 11047 5713 5714 94234 7979 5690 5691 5692 5693 5694 7311 7291 283106 5695 7314 5045 5046 5687 4193 5688 288 5689 6938 1514 7490 10399 54737 348262 80149 5315 7750 10009 60436 7088 9159 28513 11171 55810 687 93986 1460 1459 9789 1785 1457 6667 9839 4609 5931 29954 10585 94239 6935 4613 23396 60559 1488 1487 3728 54145 58505 9743 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 3030 37 34 51102 6296 35 1892 3033 142827 33 3032 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209931 Serotonin and melatonin biosynthesis 15 121278 438 1644 7166 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 96%4724289 Defective ALG6 causes CDG-1c 29929 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 96%3560801 Defective B3GAT3 causes JDSSDHD 633 1464 6382 1463 3339 10675 2719 221914 2262 9672 1462 2239 2817 63827 26229 1634 6383 10082 6385 375790 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 7314 867 6233 5753 7316 116985 207 1796 7311 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME%R-HSA-167242.4 Abortive elongation of HIV-1 transcript in the absence of Tat 2963 22916 2962 5434 7936 5435 4686 7469 5436 5437 6827 5438 5439 5430 5431 5432 9150 5433 51497 5440 5441 25920 6829 DNA DAMAGE BYPASS%REACTOME%R-HSA-73893.3 DNA Damage Bypass 55666 54107 5981 5982 5983 56655 9100 5980 83932 10459 7706 8451 11201 7353 7320 51455 8450 9768 56852 124739 9246 7398 5111 1642 57599 51514 7318 6117 5984 7311 5985 5424 6119 9978 7314 5425 6118 5426 5427 5429 10714 7415 25898 51426 57804 6233 7316 9636 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 96%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) 6775 6348 864 3458 3595 8459 861 4772 30009 7124 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693579 Homologous DNA Pairing and Strand Exchange 5888 80010 5889 7486 5982 5983 3364 472 672 675 84126 144715 83990 5810 7516 5932 7517 9156 11073 7979 641 6117 5984 5985 6119 79728 6118 5883 5884 116028 10635 1111 83695 10111 4361 7156 5890 5892 4683 580 10524 1763 545 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6791226 Major pathway of rRNA processing in the nucleolus and cytosol 5393 11340 22894 23016 23404 51010 54512 51013 6230 56915 6231 118460 6234 9349 6235 6191 6193 6192 6194 51121 6227 6229 6228 51602 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 4691 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 1453 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 6222 6224 6181 6218 6217 7311 9188 23160 79897 92856 54913 5394 28987 8780 51096 5822 114049 81875 57647 90459 10199 8568 22984 11056 705 57418 10885 10171 23246 84916 27043 27042 23481 55127 84128 51202 55131 9790 22803 81887 55813 56902 84946 117246 83732 88745 55272 10969 10607 84135 51118 10813 55720 11102 11103 65083 25879 54881 26168 27340 27341 79159 51388 9136 55759 134430 79707 1454 79050 4809 54555 26354 8602 9277 2091 10528 25926 10799 10557 10436 10438 55781 10556 23517 57050 51077 9724 10200 SARS-COV-2-HOST INTERACTIONS%REACTOME%R-HSA-9705683.4 SARS-CoV-2-host interactions 23636 9972 9631 7175 11097 23511 3105 567 8086 8021 53371 8480 10762 8678 81631 7405 6230 6231 6234 6235 6191 8767 6193 6192 6194 6227 10454 6229 7334 6228 7335 7187 9641 7189 64127 257397 5781 23118 3921 10392 7534 10971 7533 6232 3656 5777 9636 64135 3442 7529 3441 3440 23586 80143 84282 57506 91662 22863 3452 6772 27072 3451 3449 3448 3446 3445 3444 3320 3443 2197 7706 348995 140032 23339 3838 57122 10000 6201 55746 23765 3716 6203 89122 6202 857 23279 79023 51284 7532 11311 51311 6396 4153 207 208 64601 6210 9868 1387 114548 51065 6205 6204 6233 6207 6206 5648 6209 6208 6885 6188 6187 6223 6189 65082 6222 5903 6224 1147 6218 6217 340061 7297 3665 7531 7097 7096 6773 2810 112744 3326 3454 7284 79902 3654 84818 3107 3106 3134 3551 3133 9908 8517 2697 10146 3135 7082 6441 3456 7555 57617 29110 51128 3661 23367 55823 9871 9632 10427 26276 10207 5289 92359 64398 50628 6632 6628 10802 79760 9883 54960 3605 6634 5170 10484 129401 26007 6633 9688 6636 6635 30849 6637 25929 23225 79833 4927 6607 23165 8487 11218 55706 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 80152 5903 2491 5519 332 55143 699 11243 140735 3619 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 79902 5347 5525 5526 55839 5527 5528 5529 54908 6232 8655 25909 8379 9183 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 348995 348235 5048 23421 57122 220134 57082 57405 147841 51143 6249 7514 55746 4085 64105 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport 282679 107 108 109 5566 375318 551 2793 2792 2791 2790 554 2788 2787 2786 2785 2784 2783 4645 51764 94235 22841 55970 5567 5568 364 366 111 54331 112 113 89872 114 59345 8766 115 358 5575 5573 4284 2782 359 5577 2778 360 361 362 5576 363 10681 196883 343 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 96%5173214 O-glycosylation of TSR domain-containing proteins 145173 57188 10417 10418 23275 170689 171019 54437 9510 9037 5199 7058 157869 7057 9507 80070 140766 9508 9509 339366 221981 79875 81794 55901 81792 9719 56999 11093 11173 11096 11095 11174 80731 170690 54507 170692 92949 170691 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602415 UNC93B1 deficiency - HSE 81622 7098 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli 3688 24145 5029 5175 2475 1499 9641 79109 3791 4323 55615 5567 5568 6772 59284 5770 111 112 113 114 115 64223 5520 9780 302 3685 5747 5027 5575 207 5573 5577 4846 5576 2534 196883 7414 808 2324 1147 5519 84290 3690 107 108 109 7094 4790 5566 4792 5515 5518 824 826 5970 3339 3551 2793 8517 2792 2791 2697 2790 1003 2788 2787 2786 2785 2784 8912 2783 51764 94235 6696 3678 55970 10266 133 54331 59345 10413 2767 59341 253260 5586 781 2776 782 783 5296 784 2782 5290 5170 25 5291 2778 5293 10681 10203 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371598 Defective BTD causes biotidinase deficiency 686 INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes 5970 58484 10910 9447 9051 834 4790 10628 4210 22861 351 29108 114548 3326 3162 7295 24145 596 598 4791 5027 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription 5087 2648 9787 4851 22938 23129 23462 171558 23286 84441 6772 10046 388585 3280 23493 2033 1387 26508 4854 8850 3516 2173 9794 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 96%5666185 RHO GTPases Activate Rhotekin and Rhophilins 389 6242 388 54763 30851 114822 387 64130 85415 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 23460 5443 3065 4087 4088 3630 4089 6720 2308 56729 847 91584 4852 4287 84676 114907 25942 6648 4303 2309 2645 10891 3484 181 3066 23410 5105 2538 2908 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 96%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 8331 5708 5709 8337 8334 5700 5701 8335 5702 5704 5705 5682 861 5683 865 5684 8341 83737 5685 8342 8347 5686 8348 5717 8345 5718 5719 6929 11047 8340 5713 5714 7979 5690 5691 5692 4004 8338 5693 5694 7311 85236 4005 8349 5695 7314 5687 8861 5688 5689 6938 7161 8370 4331 1022 2625 2624 3013 2623 255626 6688 3021 3018 902 3017 3014 4297 474382 8970 10413 128312 94239 55766 8968 653604 9861 25 6233 54145 7316 10213 4602 5706 6886 5707 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467340.3 AXIN missense mutants destabilize the destruction complex 5519 1452 139285 2932 5515 324 5516 5518 8312 5525 5526 5527 5528 5529 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 23462 79885 3280 8850 9794 83933 7311 4851 9978 7314 6500 3066 5663 10046 5664 388585 55851 83464 23385 51107 26508 9612 9759 22938 3065 84441 1024 9734 2033 6907 4609 2648 9148 79718 28514 182 54492 57534 102 54567 6868 51564 3714 142678 8841 10013 9611 23493 10014 1387 3516 8454 6233 7316 55869 892 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 96%179409 APC-Cdc20 mediated degradation of Nek2A 9184 51529 7321 991 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51434 51433 7311 4085 7314 4751 701 6233 7316 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events 5950 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid 9249 8854 64577 5914 1592 157506 1381 1737 220 5959 195814 57665 56603 216 8608 340665 51109 5915 5916 5467 1382 1738 10901 5162 5163 124 5164 5165 6256 5166 126 127 8050 2171 6258 6257 5160 5161 112724 10170 8644 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis 8443 8540 84188 25979 55711 158835 158833 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-HSA-2173788.3 Downregulation of TGF-beta receptor signaling 4087 4088 5499 25805 64750 23645 5500 11171 4092 56937 9958 9110 51377 10273 7040 7514 7311 7314 57154 7046 7048 23327 6233 7316 5501 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9932444 ATP-dependent chromatin remodelers 8331 8337 8334 1107 8335 8313 53615 11335 8341 8342 8347 8348 8345 1108 8340 23168 79577 80349 8338 85236 1499 8349 123169 9646 3066 54623 86 8370 6595 57504 6597 6599 9112 6598 29117 3013 3065 7182 255626 8110 6601 8193 6603 26039 6602 6605 5977 6760 3021 8289 3018 2033 3017 55193 22827 3014 9274 27123 9275 3481 605 10262 474382 80205 57459 11325 8970 128312 54815 7975 22850 55766 23394 6604 8968 57680 10664 1728 4780 53335 653604 84181 2203 1387 9879 11091 2538 1105 5928 23506 65980 29998 84844 6925 8175 6749 4654 4656 11198 10992 6929 10523 9219 10951 6627 6629 23450 23451 6938 6638 7341 114825 125997 85409 170394 79843 85509 55636 196528 5105 57492 8099 26038 55205 7329 6941 22806 22807 57592 23613 10263 8932 9640 7026 10320 51639 152485 84295 60 10291 5931 94239 23350 10285 1106 10946 6632 51412 6628 1665 84991 6634 6633 83443 6636 6635 54145 6637 55274 64919 ACETYLATION%REACTOME DATABASE ID RELEASE 96%156582 Acetylation 10 9 NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717301 NVP-TAE684-resistant ALK mutants 238 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling 2064 1956 3084 5295 9542 5290 10718 145957 2549 685 1950 2069 1839 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 96%1237044 Erythrocytes take up carbon dioxide and release oxygen 6521 606495 51167 3043 51700 759 3040 51706 760 762 358 6005 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9033807 ABO blood group biosynthesis 2524 2523 28 DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance 1616 546 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA 8815 3159 11168 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 96%4641263 Regulation of FZD by ubiquitination 89780 7314 55366 8325 284654 4040 4041 8323 84870 59352 343637 340419 84133 6233 7316 9101 54894 7855 8549 8322 7311 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 96%8986944 Transcriptional Regulation by MECP2 808 817 818 5816 192670 54487 5566 27161 2572 2571 9212 25942 26523 54715 3654 4233 4986 4988 23112 5728 57690 3066 192669 3064 2593 114787 3930 9612 5468 4343 1392 3065 6446 2874 5770 2891 28996 627 6657 2904 6907 27327 7222 5775 79718 6750 28514 4208 8841 9611 2290 814 2903 4336 6515 2289 815 816 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME DATABASE ID RELEASE 96%5250989 Toxicity of botulinum toxin type G (botG) 6843 6844 6857 VITAMINS%REACTOME DATABASE ID RELEASE 96%211916 Vitamins 1592 1591 56603 340665 120227 1594 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351200 Interconversion of polyamines 6303 196743 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 96%9766229 Degradation of CDH1 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 27085 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 2060 79872 7311 1500 1499 5695 54971 7314 999 5687 4193 5688 6714 5689 1514 10399 1785 1520 1508 9861 3728 6233 7316 1495 10213 5706 5707 UREA CYCLE%REACTOME DATABASE ID RELEASE 96%70635 Urea cycle 7157 162417 384 445 435 1373 10166 5009 57407 383 23408 83884 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2122948.5 Activated NOTCH1 Transmits Signal to the Nucleus 8650 408 83737 409 23220 7311 92737 8788 4851 7314 113878 9148 28514 1272 1840 182 54492 57534 102 54567 6868 5663 142678 3714 5664 55851 83464 23385 51107 6233 7316 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-HSA-2299718.4 Condensation of Prophase Chromosomes 8331 3013 8337 8334 8335 255626 8341 3021 3018 8342 3017 8347 891 3014 8348 8345 983 8340 474382 5347 8970 128312 8338 387893 85236 8349 94239 55766 10592 8968 79648 10051 54892 23310 653604 8370 29781 8290 54145 6418 5925 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration 3678 9358 4322 10000 865 207 208 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies 56898 79611 54511 38 3158 65985 622 3155 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape 6872 2963 2962 6874 2068 6873 5434 6908 5435 5436 5437 5438 5439 6881 2968 6880 2967 6883 404672 6882 5430 6884 5431 8148 5432 5433 902 6875 6878 83860 6877 2959 2958 6879 2957 54457 2961 2960 138474 5440 5441 4331 1022 2071 2966 129685 2965 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 10762 8815 348995 79902 57122 55746 23279 79023 6396 9883 129401 9688 23225 3836 4927 3159 23165 11168 55706 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 96%75067 Processing of Capped Intronless Pre-mRNA 22916 84967 7884 4686 134353 79869 8189 8106 11051 10978 10898 1479 51692 1478 1477 23283 10914 53981 51585 29894 55339 81608 6628 6634 6636 6635 6637 25888 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) 8331 3013 8337 3065 8334 8335 1107 255626 53615 8341 11335 3021 3018 8342 3017 8347 3014 8348 8345 8340 1108 2074 474382 57459 5931 9219 8970 128312 8338 54815 85236 8349 94239 55766 7270 8968 3066 10919 653604 8370 54145 5928 57504 9112 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 808 5577 114 107 5567 5568 5613 5575 5576 5566 5573 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 96%2025928 Calcineurin activates NFAT 808 5478 5530 5532 4772 4773 5534 2280 4775 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) 3329 3304 207 23410 27429 22809 3301 847 4899 9361 3297 2099 1670 6648 3313 2309 3336 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 96%69416 Dimerization of procaspase-8 841 356 355 8737 8795 7186 8743 8797 8717 8772 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 96%8847993 ERBB2 Activates PTK6 Signaling 9542 10718 145957 5753 2064 1956 685 1950 3084 2069 1839 INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 96%877300 Interferon gamma signaling 4261 817 818 9830 7412 23650 10107 4502 3105 2635 567 5894 4938 3665 10346 10437 2634 388646 3460 4940 8651 3459 4281 4092 8638 960 3660 3107 3106 6672 3134 5724 3133 3663 5781 7341 3135 3123 3122 3120 115361 3119 8554 3118 5594 5595 3115 3113 9021 5777 4684 3127 3126 3125 4904 3662 81603 5371 79097 163351 11074 5770 55223 53840 7706 3458 5580 3661 3664 10612 55128 3716 2633 2209 117854 23321 80128 51127 3659 10379 4939 7726 85363 3383 10475 80263 3394 3717 115362 23087 815 816 6737 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%8856688 Golgi-to-ER retrograde transport 55860 51164 10671 8774 636 8775 23299 93661 5050 84516 5049 51560 29127 5870 22818 26286 22820 63908 9585 55083 23046 55605 113220 3833 3834 90990 55850 23095 10749 60561 55614 830 146909 832 11316 6836 55582 23303 124602 53407 64147 221458 829 662 51594 8398 547 8655 3798 3799 9183 1062 11014 2589 5321 5048 51143 9276 84364 1315 1314 1781 22920 1780 1778 2590 81930 84643 3796 10540 64837 1783 26153 147700 10112 26958 9493 3831 3832 3835 378 140735 51014 56992 24137 23423 89953 11004 5861 377 9371 10972 9554 10121 25782 285643 1639 372 81876 381 10959 22930 22931 11015 3797 8729 54732 56894 51226 375 11127 55738 4905 11258 10945 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 96%9615933 Postmitotic nuclear pore complex (NPC) reformation 23636 9631 3842 23279 23511 79023 53371 1104 6396 5901 7341 348995 9883 129401 3837 9688 79902 57122 5905 23165 25909 7329 55746 55706 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9635465 Suppression of apoptosis 6421 1511 2931 5594 5595 57674 5987 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196780 Biotin transport and metabolism 5095 64087 8884 56922 686 31 5096 32 3141 5091 51248 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters 10058 22 11194 23456 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 96%5545619 XAV939 stabilizes AXIN 8658 80351 SENSORY PERCEPTION OF TASTE%REACTOME DATABASE ID RELEASE 96%9717189 Sensory perception of taste 50834 50837 50836 50839 50838 5726 3759 50840 259289 259287 259286 259285 6340 119395 3710 6324 255022 259293 259292 5330 259290 259296 6337 259295 6339 54795 346562 6338 2911 2914 6330 2782 6335 29850 133060 2784 6326 6328 6327 83756 54429 80835 51764 50831 80834 50833 50832 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 96%9735869 SARS-CoV-1 modulates host translation machinery 6222 6224 6218 6217 2197 140032 6230 6231 6234 6235 6191 6201 6193 6192 6194 6203 1915 6202 6227 6229 6228 6210 3921 51065 6205 6204 6233 6207 6206 3178 6209 6208 6232 6188 6187 6223 6189 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication 3320 3326 COMPLEX IV ASSEMBLY%REACTOME%R-HSA-9864848.2 Complex IV assembly 1351 1350 1349 100131801 1347 192286 1346 341947 29090 152100 93058 1345 116228 9377 28958 84701 1353 6341 79064 90639 493753 10063 80775 51204 285521 6834 25994 80219 1327 9167 125965 389203 9997 4697 4512 4513 1329 4514 51241 1340 1337 55969 84987 1355 100303755 55744 1339 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function 1029 708 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 96%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes 6097 9575 8553 9572 5936 1628 1387 85457 150094 23373 4297 5187 8864 8863 6095 406 7942 1408 1407 4862 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 96%166786 Creation of C4 and C2 activators 4153 2220 1401 712 78989 713 714 8547 715 10584 716 5648 2219 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis 6484 6487 124872 10690 2526 10402 2525 2524 30815 2523 10317 28 6007 2529 8707 2528 6006 8708 8705 2527 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence 4171 7015 3978 4174 672 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions 3716 3976 3590 3589 7297 23529 5008 3572 9180 133396 1489 3717 1271 9244 1270 386653 3977 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways 70 8331 10395 10276 8337 5099 9138 8334 388 128239 8335 2353 1729 5062 11214 128272 117145 26230 121512 84904 192670 27161 100271715 286205 25791 8341 89846 6915 8342 8347 54848 22899 8348 50649 8345 5364 8874 64857 26523 8340 2768 57449 389337 53632 2354 445328 2475 2245 221472 8338 55701 10672 9459 10956 146 85236 389 8349 5879 147 148 23112 4771 54763 30851 9055 57690 340481 2932 192669 1382 858 79109 4316 54659 3791 55625 5781 5481 2034 27248 8370 146850 5753 2146 9287 3363 3362 998 3361 5777 3360 51009 4343 59340 6400 153 3013 154 155 3358 3357 3356 55615 1133 255626 3355 1816 83551 5562 5563 1815 6772 1814 5564 1813 6774 1812 5565 134864 319100 3021 134860 3018 9038 3017 1132 3014 3354 1131 3932 3352 5571 3274 3351 64223 3350 474382 1129 1128 10000 3269 8970 11255 128312 4935 5536 27327 3716 83439 55766 8726 8968 7532 23533 3727 51176 7525 207 208 9682 7409 653604 7415 84661 8503 11091 25937 23512 1495 5928 5929 2534 1445 6615 5087 9787 22916 23129 171558 6908 23286 4686 10460 3718 7297 1901 1025 23186 8812 2342 2958 2339 2957 25920 2321 904 905 10434 2697 84888 25999 908 90268 6610 8887 55512 8439 56928 9986 377630 81926 58489 51104 10574 10376 10576 9630 6000 8787 8786 402 9628 11171 60 5228 2767 3315 2769 572 842 7157 8928 10468 10589 23048 91010 2776 57381 54874 2631 8877 144402 8476 81704 9497 9578 23513 6692 8038 3249 23035 4485 1822 84232 4486 10653 23239 6199 8870 23179 8555 8682 10642 221002 7010 284 2118 5863 8086 22808 9693 989 54756 8036 84292 57139 5596 5597 79577 7040 3730 6194 123169 1213 1211 558 4145 4919 4920 81029 51684 142 3320 3838 861 865 2194 10250 50937 64399 91653 7919 2619 5338 9542 51072 10718 6657 145957 5829 7222 7225 7015 54514 57113 3913 1080 3914 3915 2335 2670 3918 284217 10319 3908 3909 3910 3911 3912 8313 1234 9500 7322 10454 5588 7189 10235 257397 115727 23118 8724 6591 5880 6195 6279 6280 4140 7534 1908 7533 1906 5443 4157 3065 1910 3815 4161 6662 3397 4160 3480 4159 1524 55288 7252 1081 857 53916 7410 10451 11140 6434 9886 8654 23221 29766 6093 3183 55023 11329 56254 5930 71 9318 54764 5756 4646 7431 9475 124540 23013 27316 9352 3326 2873 79869 51138 1627 87 5045 5046 5125 7046 7048 4629 51719 6794 7248 29904 1975 55004 3693 8649 1978 1977 7170 5230 7171 64121 301 92335 1981 7249 58528 10542 389541 28956 57521 10670 6009 5494 103910 4637 153129 4638 81617 5782 84335 55437 10325 2591 3955 324 7058 6667 200958 56667 57678 6319 1742 1741 1739 8772 3002 355 10211 4295 7200 7201 7332 431704 8743 56413 5031 83737 5032 6003 841 1909 6004 8737 94233 329 2798 2797 2796 2319 1907 5028 8795 84432 7186 5029 1902 6375 10273 1241 8797 2693 84109 330 10874 331 29933 222545 1991 10887 5724 10886 257313 5731 5737 64407 387129 581 2911 2358 846 8717 2915 8111 8477 2922 5996 5997 5998 5999 6846 2925 10161 6863 183 185 623 624 4314 10287 56923 6870 8490 2151 23566 4580 2150 2149 285016 25813 2147 389658 6865 5764 2829 2828 6866 6869 353299 885 886 887 2837 347148 9002 57121 338557 3814 10911 2840 2846 594857 7289 64106 374654 3827 129521 80199 128674 55811 2867 23432 2865 2735 2864 27152 2863 3710 2862 60675 4922 4923 2869 8620 680 27334 84634 3060 5367 23620 3062 3061 487 10316 488 4828 489 4829 26575 2520 9170 84539 7535 815 816 817 818 139285 10768 3708 3709 5566 6197 6196 8535 648 23463 8550 6015 4193 1912 1911 80012 8837 84733 8290 6045 5598 5327 1030 27202 3569 930 132884 23466 2121 23288 2622 3576 84455 5599 57332 7074 4915 1795 728 4908 10817 4909 5335 627 2904 8301 2549 374 596 1950 598 29924 50618 9148 28514 182 382 54492 57534 102 54567 23396 6868 3714 58513 157 9322 2017 727 718 23081 354 3817 10901 6510 3416 4318 51125 6484 6487 51114 88 1740 2906 814 4747 2902 4627 3630 2308 6929 5725 4670 3654 4986 4988 10134 2100 85455 6938 55733 57758 81610 10252 5796 26018 6421 84985 55824 3178 80824 3187 3674 3185 835 3678 1024 843 1278 6722 4303 864 6750 23327 10013 639 10014 892 650 7874 3276 80179 3280 55669 66008 89941 5910 25942 9927 64759 84951 85440 57591 5467 7422 3066 200845 29843 5771 5783 9612 26469 6597 5778 84441 2122 8793 8312 6347 54815 5054 11059 51564 23493 55620 23462 10398 6925 4617 4618 1956 7039 4654 4656 2810 51592 9219 5800 7057 7050 1003 8396 10399 3930 9021 22873 2625 25989 339745 60436 84612 7088 3726 9855 2874 84870 5915 5916 51741 2648 1958 23543 3516 80004 7073 7072 5933 4602 1107 79885 4852 4853 4854 4855 1108 5795 83933 23163 9099 5728 8408 3562 55240 3559 3558 5867 10971 5978 5979 22938 55075 5770 8471 3481 3479 57459 4435 5300 84447 4221 5305 80820 221656 347 10123 55818 51083 729230 1230 10663 1240 56670 2289 338398 1238 1237 1236 55869 1235 1233 54778 1232 170589 4985 4987 23439 5956 3792 5729 27198 27199 2064 5726 5739 2587 5732 4886 5733 5734 4887 10850 4889 2359 1269 2357 1268 8850 259289 2492 259287 259286 259285 3579 3164 3577 2488 56477 5995 4543 4544 259294 259293 259292 259290 259296 259295 353164 5660 6751 5540 6752 5539 116512 338442 54886 643 6755 6754 8811 151306 163404 5105 8843 5697 256933 79948 7504 54429 80835 7528 80834 6696 10692 9934 5473 4142 8862 51052 6446 9718 4283 6346 4158 5368 10563 6351 5371 6352 6354 6357 6356 6348 9734 6349 5030 6361 6364 6363 348 53829 6366 6367 6360 1903 6373 6372 6374 6376 6370 7323 134 135 26574 5173 5179 9890 64748 140 51554 11108 58191 8698 7253 2919 2918 2917 2916 2914 53637 2913 2912 2921 2920 7101 25 221391 8484 6498 11251 23596 6497 186 6258 187 83756 6257 165140 50831 50833 9757 50832 2826 50835 4086 50834 50837 4087 50836 4088 50839 4089 50838 2834 2833 2832 2831 122876 50840 53615 1880 57007 283869 64750 2841 4091 57486 2853 4092 2852 10803 2859 50865 1889 2861 5196 9034 9794 64805 9283 3972 3973 9290 9294 1325 2532 3627 10046 8239 832 64840 10657 10656 202559 7049 7042 83855 10755 4323 92 4325 7077 7076 3070 3624 3623 4904 1875 1874 7043 4052 4053 4054 25805 23645 3696 56937 9958 8425 3694 9110 51377 2737 8516 9101 2736 57154 3845 1437 3337 4296 8315 5245 3717 2244 2266 9530 7414 8844 10256 54518 8826 22866 7450 3690 5894 5037 2243 7094 5908 369 283455 408 409 9113 92597 154810 26524 55233 245972 51421 245973 60485 6788 6789 3163 4058 155066 10188 9114 51606 9550 4738 523 525 526 527 528 529 27043 8992 90423 127124 23545 51382 533 534 535 537 10312 50617 7037 9296 29110 23220 2056 1629 1738 1286 1285 256076 1284 1282 1299 1298 131873 7124 1297 2208 7132 1293 1292 1291 11069 10411 1287 14 5155 27329 9619 10062 5034 19 9564 160 161 1071 163 29116 1072 2277 1175 1173 341 344 346 5340 5567 5568 6678 7424 7423 2683 11180 5361 94240 1362 22852 2886 27289 222584 55704 22800 8502 11075 91544 9231 57579 57216 224 667 9528 9928 10963 10402 10608 79971 11033 27018 51699 9559 80310 55737 7059 3925 7060 8483 50999 1447 2262 4628 79784 3984 3985 216 7089 92737 8788 7091 113878 23380 57522 1840 27005 220213 9901 80728 7185 56957 7375 55072 9641 81858 1540 9825 10133 7128 124 126 127 2323 57504 112724 10170 9112 8644 9249 8854 64577 1592 157506 1381 220 5959 195814 57665 56603 8608 340665 51109 64241 64240 79658 5533 2931 5145 5578 5592 5593 5158 5148 51701 5330 5331 2780 23236 3563 2775 3560 1439 1438 3568 5573 3567 238 6801 5896 5897 2668 3400 2674 6725 1454 1452 50848 5590 387 23370 57530 56288 130399 50855 611 91 93 9252 9350 5147 200894 57167 6472 7444 7204 9743 4660 2909 94274 391 4659 57584 392 9341 394 57580 396 26030 397 398 5803 80005 7879 5337 4722 10298 10652 3954 3998 9710 81839 10788 26084 26286 4698 3688 8997 6453 7984 2010 23344 143098 63916 3336 23141 23263 5825 1794 1793 4983 3895 8987 55789 4162 7112 9217 4168 9732 27237 23191 81624 23592 11135 6811 1969 55914 2173 2172 2171 3952 1959 11343 5499 64321 5500 5346 10226 3685 5747 27 8440 6387 4650 51466 56924 4690 7852 8829 5576 4313 6655 4192 57144 2324 23767 59 5216 5986 5217 4242 56983 23509 4099 57142 4974 84894 7166 6236 2152 4066 8941 3398 5607 429 10126 3399 8061 10221 4664 4665 23237 1961 1960 7425 9306 685 127933 255324 2069 2002 1839 4804 8878 1212 1785 10253 8569 3083 4548 150 151 152 5140 9965 5289 2254 2252 2251 27006 5162 5163 8074 5164 2249 5165 2248 5166 2247 2246 152831 8823 8660 30849 8050 2264 2255 54106 9846 5160 3667 5161 8817 26281 3673 3675 1737 3570 8651 23608 118788 5159 50852 4916 7006 10019 1215 10076 10750 2242 2241 10603 57630 4734 57610 10193 3798 3799 1395 3625 10616 8776 8394 8395 2057 91851 9765 27302 4090 9241 4093 657 658 10489 659 94 11167 64388 2658 268 269 8065 9040 7428 5792 3082 5802 9982 7126 390 143282 11188 83888 10970 1488 1152 1487 10505 253980 8773 8556 50508 395 1536 10811 1535 10458 55843 10979 9815 4688 55845 4689 9235 55971 23092 143872 347902 4810 55619 10787 85360 8936 5881 10152 29 2185 64411 90865 124056 29127 613 51347 26050 3071 10163 28964 22865 653361 23075 116984 27035 55114 4952 10006 1786 58480 708 5156 9173 59349 23072 55200 399693 253959 5663 23616 5664 115703 388585 139818 55851 201176 83464 57514 23385 51107 57636 26508 55219 55227 9844 26092 124997 58504 1124 1123 10409 91452 114793 57679 114885 57569 27145 92799 2652 57572 10602 752 55968 51133 55852 10144 64333 10093 116985 10092 25963 10095 79834 9912 10094 101059918 79822 10097 23526 10096 54438 1855 157285 57105 29062 111 9938 10810 23779 112 51291 113 9824 114 56990 115 10435 83478 1857 84681 1856 7454 120 7456 84317 9644 23268 51306 9411 147179 94134 393 399 136 51566 84364 171177 148170 346562 23348 5575 89839 23580 84144 2802 10800 65992 10160 25894 55831 644150 51479 54509 26999 55717 10928 5577 1730 5336 93663 26049 9590 5613 57473 719 123720 80115 10109 8976 158747 196883 57120 8153 6850 57480 2771 117289 2770 695 84986 343578 10552 50619 2781 157769 221178 2773 257106 107 153478 108 114822 109 51517 29984 11060 445582 8975 152273 81847 79180 23074 80243 23197 23252 5987 8658 80351 2444 120892 10457 3561 5332 2550 3084 2562 2561 2560 2554 26960 2567 2566 1852 152559 10645 1850 11221 55879 5774 1844 1843 5582 1847 144165 23229 64130 9568 2774 84254 5923 5924 2676 2675 5623 64096 5786 5584 8767 4615 6010 2779 4205 6285 6288 51135 4902 9048 466 1796 51231 1849 1848 1846 1845 54845 22906 6753 9742 23322 9738 79659 261734 51098 9861 8454 6233 7316 5579 10213 6885 5706 79809 26160 5707 5708 5709 1147 5700 5701 5702 5704 5705 4790 5682 5683 4792 5684 5685 2847 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5970 57539 5695 7314 6500 3551 5687 5688 8517 5689 55081 5241 7376 55764 6256 2099 8100 367 2908 9759 5468 5914 79598 11127 57728 8481 54903 1111 10524 22836 7321 51209 5870 983 5347 9146 6456 4233 8027 6455 2060 9367 1500 1499 30011 999 6457 867 10254 6714 6014 4893 6654 6016 3265 9261 2889 673 1399 1432 1398 5898 5899 4803 25759 5594 5595 6300 6464 10818 4914 5906 57498 5600 53358 7867 5900 7529 5603 5604 5605 2033 6907 2316 8648 7514 10499 10498 79718 4208 4209 8204 8841 9611 2885 6777 6776 1387 1386 5469 51523 1105 1509 10424 23028 4772 2288 5451 25780 5534 8202 23030 2280 7764 1655 808 7090 5530 3169 5532 9166 9687 10125 23189 2494 7033 7392 4001 7391 7531 7031 8851 1020 10728 8650 351 10018 356 995 8828 1759 2309 3725 6708 6709 4851 9978 7484 1272 7483 30817 5741 2793 2792 2791 2790 51332 6711 7480 6710 9340 7482 6712 7481 2788 2787 796 2786 80326 797 2785 26052 116 2784 2740 117 799 2783 6469 4684 51764 94235 3375 57731 1394 1393 54361 1392 10048 55970 113091 79924 10266 100996717 51548 5744 1999 5745 10268 100996763 388677 5746 10267 23768 23769 50846 90226 2692 2691 6608 133 54331 51384 114131 59345 2642 2641 7855 7976 976 8321 7473 8322 7472 89780 7475 7474 8325 7433 6344 7477 8326 7476 7432 6343 8323 7479 8324 7434 7478 8643 2782 7471 3549 84658 2778 2535 2015 2696 2695 7349 10681 11211 1604 5727 10203 8452 9462 8607 4763 64926 84078 8831 399473 10156 161742 200734 22821 153090 8437 5921 5922 7027 1019 595 1017 896 1871 898 1027 1026 147111 7029 1869 2322 54908 6232 8655 25909 8379 9183 10272 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 9580 23332 79003 27121 55055 79412 83999 81565 343637 22919 1455 348995 27123 348235 9736 83595 5580 9126 5048 11197 5321 10023 23421 156 5137 50964 57122 5153 54894 220134 8549 5136 57082 57405 6423 147841 6422 51143 6259 6658 6249 55746 6659 23401 4085 8295 64105 55366 401541 284654 607 23279 90780 79023 10403 57680 56998 54820 80776 283149 701 4040 54821 22943 6396 4041 378708 59352 25776 1781 26108 23122 55553 1780 440193 340419 79172 84133 1778 6736 81930 10735 55920 84643 3796 4846 9047 9793 91687 6461 2887 57551 3643 79682 5905 64837 1783 5501 83540 147700 80152 5903 2491 5519 332 55143 699 3831 11243 10274 6778 140735 3619 5515 11004 89953 5516 5518 9212 25936 8243 11130 64946 166 79980 10726 79902 5885 5525 5526 55839 5527 5528 5529 23256 5020 551 5021 552 553 554 1832 9414 10959 1829 1828 7082 836 5440 5441 2963 2962 5434 5435 5436 5437 5438 5439 5430 5581 5431 5583 5432 9162 5433 8527 26090 8525 8526 57406 221955 1460 10636 160851 1459 1609 10888 1457 747 26086 4609 1608 10846 5931 1607 50940 84152 1606 8405 85397 139189 8601 53834 10413 126006 51289 3640 8622 5141 10022 3091 122042 5143 4067 117579 94239 5144 9070 5138 6019 339403 5139 4613 5151 59350 6793 6001 6002 65124 9402 5585 5150 5586 53831 253260 57761 9560 55160 23002 11245 29126 11250 142678 23365 285601 115557 51422 26166 9181 2838 5294 29941 2843 85415 5295 2848 5296 1894 5058 4649 29899 27115 6242 2854 5290 9754 2850 2040 5170 2870 3728 5291 63940 54443 5293 54145 9748 9826 11113 940 941 90627 64283 942 9828 6932 6934 284119 50650 5063 9639 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 96%168179 Toll Like Receptor TLR1:TLR2 Cascade 2353 8651 841 7186 8767 4615 4791 57162 84166 4205 10454 7334 6285 7335 929 6288 11274 7189 64127 6283 3146 51295 257397 51135 9261 4214 23118 9683 9684 6195 1432 6279 10392 6280 28512 79155 57161 79671 5594 177 5595 121457 246330 28511 59307 3656 9097 466 5600 51231 114609 1849 7867 948 1848 11213 1846 6271 1845 5604 23643 4208 7099 1386 8454 6233 7316 1326 6885 2244 2266 23291 80216 92610 695 1147 5519 2243 4790 7097 7096 351 4792 5515 6197 6196 4793 5516 5518 8945 3725 3654 5528 7311 5970 7314 6500 3551 8517 5608 5609 6416 5601 5602 5606 10333 5598 2002 5599 7157 9252 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures 3691 1297 1296 1295 1294 3655 1293 1292 1291 1290 1302 1301 1289 1300 5339 1287 85301 1306 4316 1514 1515 5118 4314 4318 1278 1277 4322 7837 84171 4015 4016 1520 4017 84695 7093 1508 7092 649 50509 1286 1285 256076 1284 1282 1281 1280 80781 3914 9313 255631 1299 3918 977 1298 131873 3909 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD 215 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 96%4641257 Degradation of AXIN 5708 5709 5700 5701 5702 5704 5705 8313 5682 5683 81847 5684 64750 5685 8658 5686 80351 5717 5718 5719 11047 5713 5714 8312 7979 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 5689 9861 6233 7316 10213 5706 5707 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels 3773 3758 3766 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 96%5689896 Ovarian tumor domain proteases 64135 80124 55593 7321 23586 84282 57506 54764 55611 324 23252 8737 7706 983 78990 79589 8767 79931 7311 10318 7314 89122 7157 55432 5728 8517 56957 7187 7189 64127 387 7128 7415 10392 79155 2099 6233 7316 161725 PLATELET DEGRANULATION%REACTOME%R-HSA-114608.5 Platelet degranulation 5099 5267 350 94121 8407 12 5155 1 51097 23052 9749 135228 54495 5196 813 5175 7114 3671 66005 7040 6813 226 7123 29106 83706 10184 51571 967 7422 5874 3699 7273 54863 2 81 5768 7044 22915 10490 2621 29789 197 213 51368 5552 22927 2162 1072 2277 3309 7042 10916 5627 6403 7078 7873 3273 1521 6414 7076 308 948 3700 5340 5341 5345 3959 54676 1893 259215 78991 7043 6678 9948 139322 6694 7424 5004 7423 334 5919 55664 3481 374354 3479 10447 5005 27154 335 2316 51706 3827 5054 88 1675 6647 10257 2244 2266 10487 7414 808 5216 5478 7450 3690 2243 7094 351 5265 2153 87 7057 2157 5660 3674 5473 710 928 7018 1191 1950 7277 3082 2335 3920 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956551 OTC leader sequence variants cause OTC deficiency 5009 OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling 808 2770 817 818 5530 5519 5532 2774 2773 107 108 10768 109 3708 84254 3709 1020 5515 5566 5516 5518 4988 5528 5332 2793 2792 2791 2790 2788 2787 2786 2785 2784 5594 2783 51764 94235 5443 9630 55970 5567 5499 5568 111 54331 112 5580 113 5533 3838 114 5321 59345 156 115 5137 5153 84152 5136 26960 2767 5578 5141 5143 5144 3710 2769 5173 5330 5331 23236 346562 5575 10645 5573 2776 5582 2782 5577 814 5613 5576 10681 5534 196883 815 2771 816 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 96%392518 Signal amplification 2770 9630 55970 2773 6915 14 54331 5321 59345 5028 64805 2767 10672 2769 2793 2792 346562 2791 2790 2776 2788 2787 1432 2782 2786 2785 2784 2783 10681 51764 94235 2771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation 9341 51529 3105 7321 567 8881 64682 11065 8697 7324 8678 10393 29945 27338 29882 5698 246184 5699 996 51434 653361 51433 5696 5720 5721 7322 997 7334 7335 29116 6279 6280 22863 23643 3685 8453 2209 7099 54778 695 5930 7097 7096 3107 3106 6921 9978 6923 3134 3133 3693 3135 26272 26234 6468 10333 26190 26270 8673 55294 51128 2923 9871 10517 9632 7323 10427 84261 23327 26224 5289 54461 80196 10802 10484 30849 8452 84078 7332 5071 83737 8651 64750 154881 23608 6478 7325 6477 131405 283807 221687 79654 51088 9616 90678 7318 10273 7317 56658 4615 7319 10533 3093 22888 9870 55176 7336 9902 150726 6890 10425 6892 64718 6891 118424 929 29927 57630 6810 23295 23480 200845 55336 50489 7327 10952 3146 7326 197131 9867 51343 7328 6502 4734 4360 10422 54926 9520 65264 10193 10075 93611 127247 3309 401036 79791 811 55585 57520 89910 51665 114609 7337 51666 948 26091 55905 6271 63891 63893 142686 991 57531 821 64167 142685 55236 51676 142689 223082 22954 91694 10293 9666 51320 84676 80204 10616 7320 57542 51444 11146 135892 55008 6047 6049 23376 23014 57674 143279 25793 84231 11275 89122 57154 9320 11059 55819 64410 90025 1520 51752 222235 84937 140691 51465 6396 54850 140456 140458 90933 140459 90135 25897 25898 9690 146330 9861 140460 8454 140461 6233 140462 7316 255488 114088 54620 23352 10213 2244 868 5706 8916 2266 23291 115290 5707 6737 5708 7704 5709 55958 1147 8139 390594 5700 127544 5701 55284 5702 84961 5704 27246 5705 2243 8924 122769 8925 5682 64320 5683 9354 81559 5684 55175 84708 5685 7174 27252 5686 5717 51130 22872 5718 114907 642 5719 51132 26046 8945 11047 9903 5713 9246 5714 9554 4591 25847 7979 158506 5690 92369 5691 55182 5692 126433 5693 26259 5694 64219 7311 7064 23304 5695 201456 7314 6500 80028 3551 144699 899 5687 84861 5688 92912 8517 10477 5689 26268 55070 90293 84727 92591 1514 26263 26267 53339 10489 285231 89890 4012 9820 1515 26235 26118 79176 26232 55521 84085 4008 9021 9817 51725 9039 26249 25831 8065 55658 140739 51619 9040 148581 79876 79754 84541 9730 154214 51191 151636 80176 23194 7428 9604 136371 10324 142678 8773 1536 1535 4688 4689 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 96%9936686 Aggregated β-amyloid interacts with fibrinogen 2243 2244 2266 ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399710 Activation of AMPA receptors 2892 2890 2891 2893 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 96%389356 CD28 co-stimulation 5519 55615 5062 117145 5515 5516 5518 3932 64223 5525 10000 5526 2475 5527 5528 5529 9020 4067 5879 9402 253260 23533 57761 7525 79109 207 208 5294 7409 5295 5296 5058 8503 1493 5290 5170 5291 146850 5293 1326 940 941 2534 942 998 5063 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation 6222 6224 6218 6217 6230 6231 6234 6235 6191 6193 1965 8894 6192 6194 1968 6227 6229 6228 1975 1977 3921 1981 1974 1973 8662 8663 8661 8666 8667 6232 8664 8665 27335 3646 51386 7458 8668 8669 10480 1964 2197 140032 6201 6203 6202 26986 6210 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 96%2514853 Condensation of Prometaphase Chromosomes 9133 891 64151 983 10592 1460 1459 1457 9918 23397 10051 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203754.3 NOSIP mediated eNOS trafficking 4846 51070 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors 2770 55970 2774 2773 107 108 3760 109 3761 2550 3759 3772 111 54331 112 113 114 59345 115 3762 3763 3765 3766 3768 2793 2792 346562 2791 3773 2790 2788 2787 2782 2786 2785 2784 2783 10681 51764 196883 94235 9568 2771 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.3 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 8331 8337 8334 8335 10001 1050 8341 8342 8347 8348 8345 8340 79611 51129 8338 29079 85236 8349 4023 8370 9612 5925 9862 84649 90390 7403 3013 2167 948 11343 255626 3991 23175 3021 3018 2033 3017 5346 3014 6907 474382 8648 8970 10891 128312 22976 51003 10499 84962 55766 79718 8968 79447 133522 84246 8841 9611 23411 653604 1387 84661 9443 23054 11091 8085 5469 9442 5929 9440 8202 9439 2494 1020 9477 6256 10555 57104 8800 2874 729359 60481 1024 7069 63924 9282 2180 9968 9969 9370 22822 57678 94239 9070 6319 5166 25 54145 10025 123 58508 892 SIGNALING BY PTK6%REACTOME%R-HSA-8848021.4 Signaling by PTK6 2064 1956 5921 120892 10457 63916 7311 1793 5879 7314 867 9564 1019 595 4893 1017 3265 898 2034 6421 1398 1027 9844 10657 10656 5753 202559 2908 685 9021 27043 2069 1796 1839 116985 3084 6774 5770 9542 10718 145957 1950 6725 3091 5829 387 207 55620 6233 7316 2909 APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 96%75153 Apoptotic execution phase 6093 5062 4001 840 2620 118 7431 4137 28988 5339 841 329 3009 3008 3007 2339 3006 660 3005 6709 10134 1499 51765 999 3024 8428 22985 6304 10059 5588 3146 1832 1830 100506658 9414 1829 1828 7082 836 5317 839 63967 324 2934 3837 5580 1677 1676 3148 5747 3836 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation 3678 3688 2335 4680 1088 634 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 993 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 9978 7314 6500 5687 5688 2932 5689 11200 1432 1263 5600 1454 1452 79858 1111 9861 8454 6233 7316 10213 5706 23291 5707 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System 8331 8337 8334 7133 8335 2353 1729 5062 8341 8342 12 8347 14 8348 1 8345 8340 5175 8338 4791 10577 85236 8349 5879 4771 967 161 11001 30 2 5768 5781 51411 197 8370 1072 998 5777 3273 3013 255626 5567 84061 5568 3417 3021 5004 3018 3017 3014 978 230 3932 2548 5005 474382 8970 128312 9020 2683 1650 8968 2799 7525 7409 653604 7415 5834 5836 1326 2534 10855 2588 28988 960 3101 178 8887 55276 10694 10576 10383 2934 60 245913 5211 245936 245937 245938 245939 503618 613210 613211 245930 503614 245932 5223 245911 842 245934 7157 503841 641517 117285 613209 400830 1673 4125 140850 1672 245927 245928 4126 245929 245940 55894 81623 100133267 140881 26007 644414 504180 2992 3984 5236 24145 57126 51071 226 929 7187 9641 8411 26253 353376 80231 64170 3663 50856 1540 148022 10010 64581 64145 170482 10133 7128 10462 93978 338339 945 5627 11314 9636 3304 4860 272 353 5873 3320 196051 23646 84513 3837 5611 23200 1265 79895 4282 1727 5266 538 8876 23250 196527 1823 10396 51248 121260 5023 327 5320 9218 5338 10555 79888 51316 634 10890 427 7226 51552 387 5971 3385 3384 9252 30835 9140 9474 3920 391 7448 8907 55593 5657 567 26 7879 5337 10788 63916 1794 1793 8987 7322 997 10454 7334 7335 5588 7189 10235 257397 23191 115727 23118 3684 5880 6195 6279 683 6280 961 8694 3687 3689 2171 326624 64135 3442 3441 3440 23586 80143 84282 57506 3452 401258 3451 3449 3448 3446 3445 3444 3443 7706 5878 5869 302 3685 5747 53916 53917 1315 4650 7410 4690 3615 3614 10451 4831 2215 10487 6093 71 5329 3326 5476 8514 51719 9761 55004 8649 4758 9545 28956 29099 2002 23412 143662 8673 118430 6616 3312 4582 5199 4583 2517 4584 81567 4585 1522 4586 1785 200958 727897 56667 10071 94025 8895 140453 5289 4588 4589 283463 394263 30849 54106 9846 8904 8772 3553 4257 834 9342 837 838 25852 83737 8651 841 8737 329 11035 7006 51816 3606 7186 7318 57162 79792 10533 330 3093 3240 1991 5724 4069 1471 6386 1687 2358 3015 3146 6406 7276 81619 6836 728358 417 1671 10075 1670 1668 5645 5646 1669 2147 4311 290 22954 10159 4064 3929 671 9450 3827 4842 89122 3710 8566 6947 3937 23352 3702 7462 6737 10768 3708 3709 5566 6197 6196 7295 9246 93100 410 5608 5609 6416 5601 5602 5606 3080 4179 5269 1361 5598 1380 5328 10877 10878 9039 730 731 27202 710 732 7294 930 975 9040 733 3456 735 81494 3078 5599 3075 1370 1191 3426 51191 1369 722 725 728 729 5335 596 1143 598 1938 1915 102 10970 8773 1536 54472 1535 10458 4680 4688 55845 4689 240 4317 721 727 629 10787 717 8936 718 10152 1088 8972 3071 1118 10163 653361 64386 10006 101 708 4843 140885 4973 6518 5663 1084 6402 23385 9844 3055 965 54210 64333 10093 10092 10095 4210 10094 10097 23526 10096 4318 10810 6993 10326 2268 51125 7454 22914 7456 5027 147179 10910 1511 10450 684 4620 2209 8778 4641 5589 2214 2212 4651 9868 29108 644150 114548 54509 26999 27180 5336 4644 124599 719 10109 8976 5094 158747 342510 4627 6850 80216 92610 3824 695 126014 100132285 10552 9051 51517 11026 7097 7096 9436 23197 23601 2444 3654 2665 3107 3106 3903 11031 3133 10288 122618 3683 22931 10333 84329 835 10628 4057 843 847 1654 6515 210 55860 5049 5788 4718 8767 4615 54209 84166 4205 6285 6288 11274 64127 7305 6283 6727 51295 51135 4214 9683 9684 7100 10392 28512 79155 57161 79671 177 121457 246330 81793 28511 3656 59307 9097 466 51231 114609 1849 948 1848 11213 1846 6271 1845 353189 475 6556 203068 9588 2950 9861 8454 6233 7316 10892 10213 6885 5706 23291 5707 5708 5709 1147 84433 5700 5701 5702 5704 5705 4790 5682 5683 4792 5684 4793 5685 5686 5717 5718 5719 8945 2821 11047 5713 5714 7979 5690 5691 2206 5692 2205 5693 5694 7311 5970 5695 7314 6500 3551 5687 5688 8517 5689 8915 22861 1514 1513 1515 5315 3958 80184 138050 51082 84265 55703 11128 51728 9533 79132 54476 27297 661 54941 4361 10623 171568 22875 374395 10549 201294 55718 10622 1116 10621 2204 1476 80301 932 10875 820 3482 2352 7321 116844 387263 10857 3608 114790 124583 388698 963 388697 968 51209 83716 5870 127829 4332 10493 160364 79930 9798 8804 23218 5553 5795 5787 5547 4353 374403 25840 56954 11322 5799 1499 23317 55754 8836 11333 23406 64114 89777 57826 4893 566 6317 6654 9961 3265 8993 9261 4033 25801 221 56888 55313 1432 1398 8635 10321 1378 9725 10562 441864 6590 5594 84443 5595 6300 51646 5273 8398 54918 5036 5906 29952 199675 5600 5284 154664 7867 9522 9535 8560 5603 6036 5604 6278 6037 55 6286 25798 25797 7130 6282 387921 10394 383 11240 175 150372 2033 3043 11010 23643 23593 3162 10043 100049587 3916 51806 222487 83858 22918 2717 1992 338 80142 8288 5300 9145 57020 258010 1774 5775 84766 2760 4208 3848 84514 7099 79169 94103 26578 5912 5806 23071 84418 2896 1387 729230 1386 1509 4772 4773 1235 5534 4775 808 5478 5530 5532 10125 351 56729 823 2357 1759 3725 3579 3577 6709 57153 317 5660 8621 26052 23114 5473 976 5864 80331 7323 2919 84658 47 25 1604 2990 3074 2720 411 830 829 8655 284266 2519 7077 5068 80341 117159 130120 1113 3347 3346 149954 55600 51297 140683 6039 3809 5580 3810 3813 3822 92747 114770 114771 338324 51143 58484 81622 7098 84659 51284 1520 5641 51311 1508 116842 7184 4153 2220 128859 10578 1401 4025 1675 3004 712 78989 1778 713 57119 714 57115 8547 715 10584 4846 716 122665 5648 2219 2244 7520 2266 1660 2547 7414 115004 3310 1512 5591 81844 11277 8826 9447 5519 170506 3818 2161 51428 5894 340061 10120 3428 3665 2243 9208 6778 5908 197358 5515 5265 5516 5518 4048 79980 5528 1075 58485 245972 966 245973 3163 1832 155066 9114 51606 9550 1828 836 2512 5317 5440 523 5441 525 526 527 528 529 8992 90423 2495 127124 23545 51382 5434 5435 533 5437 534 535 10312 3934 5581 50617 9296 55832 1460 29110 147945 3661 23220 81030 917 4067 920 6793 9402 53831 5295 5296 5058 5290 2040 5170 5291 3728 54145 2207 5063 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-5651801.3 PCNA-Dependent Long Patch Base Excision Repair 5424 6119 54107 5425 6118 5423 5426 328 5427 5981 5982 5983 56655 10714 2237 57804 5111 3978 6117 5984 5985 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%2565942 Regulation of PLK1 Activity at G2 M Transition 11116 7531 54930 79866 5566 79959 5518 6790 891 93323 983 8945 22981 5347 80254 55755 10806 10121 7311 7314 6500 9662 55835 10733 10133 80321 55125 9814 115106 8655 79441 9702 5108 55142 10383 22897 10382 10142 5116 23332 80184 5500 3320 22919 7846 5048 23354 8481 7840 11064 121441 22994 9133 22995 84962 7283 7277 55559 203068 1454 8636 55722 4751 11258 1453 7532 54820 84131 9738 11190 4957 1781 95681 1778 1069 5577 8454 6233 7316 9793 54801 10540 4218 23291 4659 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 96%9935598 FXIIa, PKa activate coagulation factors 2160 3818 2161 2158 2812 3827 2815 2811 2814 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 96%68952 DNA replication initiation 54107 5557 5558 5426 5427 56655 23649 5422 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism 7957 51181 92579 6476 2588 3795 6448 6888 2990 3938 3373 2548 5507 22934 3425 2542 138050 2720 411 7311 3423 229 7314 8908 2799 4669 378884 6233 2998 2538 7316 2997 2632 2992 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions 1601 1213 8218 1211 1759 1785 2697 1212 1173 SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL 54675 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions 2324 7423 7422 2321 2277 3791 5228 7424 ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 96%3371568 Attenuation phase 3304 10728 3312 3281 3320 2033 1387 3297 3326 3306 3305 3337 2288 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 96%68875 Mitotic Prophase 8331 23636 9972 9631 8337 7175 8334 11097 23511 8335 8086 8021 53371 8480 10762 8815 8341 8342 8347 891 8348 8345 7443 983 8340 221496 5347 2010 8338 85236 8349 10592 10051 4926 23592 8370 9663 5594 5925 3013 255626 64900 23175 3021 3018 3017 3014 348995 57122 474382 8970 128312 5578 55746 387893 9133 55766 23279 79023 8968 10776 79648 5862 255919 84930 2029 6396 55844 54892 23310 653604 8548 23399 29781 26003 5579 5903 5519 4001 5515 2801 5516 5861 5518 79902 64689 8615 140609 10783 81876 91754 8290 6418 94239 9883 129401 9688 54145 23225 4927 23165 55706 SEPARATION OF SISTER CHROMATIDS%REACTOME%R-HSA-2467813.4 Separation of Sister Chromatids 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51434 51433 5347 9700 54908 6232 8655 25909 8379 9183 23047 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 113130 348995 348235 9126 5048 23421 57122 220134 57082 57405 147841 51143 6249 55746 7514 4085 64105 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 1781 23122 23244 1780 79172 1778 81930 10735 9861 55920 84643 6233 3796 7316 9793 91687 57551 10213 79682 5905 5706 1783 5501 5707 83540 5708 80152 5709 5903 2491 5519 5700 332 5701 55143 5702 23063 5704 699 5705 11243 10274 5682 140735 5683 3619 5515 5684 11004 5516 5685 5518 9212 5686 25936 5717 8243 5718 11130 5719 64946 79980 11047 10726 5713 79902 5714 5885 7979 5525 5690 5526 5691 55839 5692 5527 5693 5528 5694 5529 7311 5695 7314 5687 5688 5689 9232 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%3000170 Syndecan interactions 3691 3673 6382 3690 3655 9672 3693 8573 3371 2247 3688 51399 87 6383 3685 7057 6385 7040 5578 7448 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression 6230 6231 6234 9349 6235 6191 6193 1965 8894 6192 6194 1968 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 1974 6133 1973 6132 8662 6135 8663 6134 8661 6137 8666 6136 8667 6232 8664 6128 8665 6129 27335 3646 6142 51386 6141 7458 6144 8668 6143 8669 6146 10480 6147 1964 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 26986 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 6222 6224 6181 6218 6217 7311 1975 1977 1981 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 96%5579017 Defective CYP11B1 causes AH4 1584 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling 7046 7048 7049 7042 10755 408 7040 409 DISEASES OF HEMOSTASIS%REACTOME DATABASE ID RELEASE 96%9671793 Diseases of hemostasis 5624 7450 2157 2147 2243 2811 8460 2153 11093 2160 2677 2159 2158 196527 8459 2812 5627 2244 2815 2266 2814 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 96%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV 594 1629 1738 593 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 117145 8471 3481 3479 3480 2549 8483 5140 9965 4893 57761 6654 5289 2254 3265 2252 5781 2251 208 27006 8074 5295 2249 5296 2248 2247 2246 5290 152831 5170 8823 5291 8660 30849 2264 2255 2323 2322 54106 10818 9846 3667 8817 26281 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins 5624 5045 2159 2158 2147 2155 8858 632 5627 2621 SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-HSA-5654699.3 SHC-mediated cascade:FGFR2 4893 6654 2254 3265 2252 2251 27006 8074 2249 2248 2247 2246 8823 2255 8817 26281 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 1593 10998 1646 6718 1645 80270 11001 1109 10858 51302 1582 8644 23600 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%264642 Acetylcholine Neurotransmitter Release Cycle 8497 8499 10815 10497 9256 6844 6616 6857 6804 22999 8500 8541 1103 6572 5864 60482 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432047 Passive transport by Aquaporins 282679 364 366 4284 375318 359 89872 360 361 362 363 358 343 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME%R-HSA-5659996.4 RPIA deficiency: failed conversion of R5P to RU5P 22934 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH 2678 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex 23439 4087 4088 3690 4089 7321 64750 51592 1025 4092 3688 8812 10273 7040 7311 7314 7050 5045 7027 867 7046 7048 904 905 8239 3693 4738 9612 5594 7029 5595 7049 7042 5494 1030 60436 22938 3065 142 3726 9040 5499 4904 1875 1874 7043 4052 1024 4053 4054 25805 23645 5500 2033 3696 11171 56937 9958 8425 1278 3694 9110 6667 51377 4609 8516 3685 7514 7323 5054 57154 23327 50848 5590 4221 387 23370 57530 9611 56288 50855 25937 6233 6498 7316 6497 5933 2280 5501 892 54778 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 96%5602498 MyD88 deficiency (TLR2 4) 114609 695 948 6271 7099 929 2243 7097 7096 3146 6279 23643 6280 10333 2244 2266 4615 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 4851 28514 182 102 54567 6868 3714 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) 246213 HYALURONAN METABOLISM%REACTOME DATABASE ID RELEASE 96%2142845 Hyaluronan metabolism 11261 3161 8692 55576 3038 3037 3036 26503 2990 23553 3373 960 8372 57214 3074 3073 10057 6677 10894 6548 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K 154807 79001 29914 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9028335 Activated NTRK2 signals through PI3K 4909 5290 627 2549 5295 4915 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 96%162658 Golgi Cisternae Pericentriolar Stack Reorganization 9133 5862 8615 2801 81876 5861 8548 891 983 26003 5594 5347 64689 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 96%9754119 Drug-mediated inhibition of CDK4 CDK6 activity 1021 1019 595 894 896 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs 3815 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion 2770 55970 775 111 54331 112 59345 150 2793 152 2792 2791 2790 9254 2788 783 2787 784 2782 2786 776 2785 2784 2783 10681 51764 94235 2771 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629597 Highly calcium permeable nicotinic acetylcholine receptors 1137 1136 1135 1134 8973 1143 1142 1141 1138 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%9637690 Response of Mtb to phagocytosis 7314 1511 4843 26276 7879 2023 5987 51606 6421 5230 3837 5594 6233 2931 5595 7316 9146 5868 11151 80824 3836 57674 7311 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 96%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 291 292 293 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME DATABASE ID RELEASE 96%5619063 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) 55315 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 51606 9550 427 533 523 526 527 528 529 8992 9114 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse 389 6093 4628 79784 10398 10507 388 3984 2064 3985 4629 387 27289 23365 9475 5364 9826 103910 4627 4637 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants 11116 399687 8805 11052 9208 26127 6772 1523 6774 5295 613 6777 6776 5290 9846 7750 IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 96%9732724 IFNG signaling activates MAPKs 3716 3458 5894 5594 5595 3717 3460 3459 SOMITOGENESIS%REACTOME DATABASE ID RELEASE 96%9824272 Somitogenesis 5708 5709 5700 5701 5702 5704 134701 5705 5682 5683 84667 343930 5684 3955 145873 10683 5685 5686 5717 5718 5719 6911 11047 5713 5714 7979 5690 5691 5692 5693 5694 1499 5695 4851 28514 5687 5688 5689 51176 2043 9861 3516 10213 5706 5707 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK 6119 7314 6118 5981 5982 5983 5980 10459 51426 51455 5111 6233 7316 6117 5984 7311 5985 RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events 2652 5956 24 5959 145226 7276 611 64220 5950 9227 6017 5947 222236 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 96%198753 ERK MAPK targets 1849 1848 1846 5519 1845 4208 4205 5515 6197 6196 5516 5518 6195 1432 9252 5594 5595 5598 5528 2002 51231 5600 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 96%2029482 Regulation of actin dynamics for phagocytic cup formation 695 10552 10787 3984 8936 71 51517 10152 3326 3071 10163 63916 10006 1793 5879 4771 23191 1398 9844 1072 5594 5595 998 10093 10092 10095 10094 10097 10096 3320 60 10810 7454 7456 5747 917 147179 4620 4650 2209 7410 4641 2214 7409 2212 4651 4690 644150 5058 26999 10451 25 4644 10458 10109 8976 55845 4627 6850 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196849 Metabolism of water-soluble vitamins and cofactors 2350 26119 81693 8029 683 5646 5096 4594 4363 166785 5095 326625 27249 25974 113235 54956 143 56965 83666 79668 84875 54625 4907 10135 25902 6470 83594 55328 23057 1719 160428 9962 2694 9963 8566 1727 200895 1528 60386 441024 952 4522 4524 6947 54 160728 80308 23475 79581 128240 54981 55034 64087 5644 10840 55163 56922 27010 4338 55739 1504 349565 133686 55065 8034 3141 55191 8875 440387 8876 5167 27231 5168 10243 79178 8884 5169 316 2194 92014 80025 80704 284439 9390 93100 119391 254552 64802 80347 51293 53354 686 79877 79646 10588 60496 65220 55229 6573 79717 113278 51248 27304 60490 81034 10797 55312 10560 5091 5826 6513 55788 4552 9446 4837 4548 6948 31 32 4036 6472 6515 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159230 Transport of the SLBP Dependant Mature mRNA 23636 22916 9972 5903 9631 7175 10482 11097 7884 4686 23511 8086 8021 53371 8480 10762 348995 79902 57122 55746 23279 79023 6396 1977 9883 129401 9688 23225 4927 23165 10189 55706 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 9125 25904 4869 9337 7157 55835 55571 7832 23019 5325 4850 1263 995 28984 85456 29883 4848 246175 4849 10769 57472 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) 22987 9899 6843 9900 6844 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 96%9700206 Signaling by ALK in cancer 3002 5903 7175 3831 7297 3587 192670 27161 4170 891 22872 26523 3725 4478 50616 7311 7291 6194 1786 9978 4869 7314 1213 6500 1639 4193 57690 192669 10342 9648 2305 5551 7170 5601 7171 29851 51530 1026 5594 5595 80304 5925 10818 4008 5777 471 3799 4343 8878 3065 3726 5599 3662 6772 1051 6774 6238 8496 10817 5335 597 57674 1937 7157 833 3092 57448 5495 5573 53335 238 2885 5295 5296 27436 6801 6776 9451 5290 5291 8454 6233 7316 7535 2335 3586 3667 4627 7414 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 3082 4233 6774 NUCLEOTIDE SALVAGE DEFECTS%REACTOME%R-HSA-9734207.3 Nucleotide salvage defects 100 3251 353 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%1280218 Adaptive Immune System 8331 7004 8337 7003 8334 7005 8335 2353 5062 10613 117145 100128731 192670 27161 11069 8341 10411 8463 8342 8347 8348 8345 91445 6048 26523 8340 10987 53632 2354 2475 91319 8338 4791 10956 85236 8349 5879 6185 23112 23476 6184 160 57690 161 2932 192669 746 163 79109 1603 29116 5781 2034 3123 3122 27248 3120 8370 3119 3118 146850 79139 151888 3115 2146 3113 1175 998 1173 5777 51009 4343 6400 3013 3127 3126 3125 55615 255626 5567 23308 84061 5568 5562 5563 6772 5564 6774 5565 3021 3018 3017 3014 80380 3932 5571 7991 64223 474382 201595 10000 3703 8970 128312 27327 9020 3716 83439 55766 1650 8726 8968 10331 7532 23533 3727 51176 7525 207 208 7409 653604 7415 84661 8503 11091 25937 5133 8764 23512 1326 5928 5929 2534 1445 467 29760 973 974 6921 6923 1639 26272 26234 6468 26190 26270 55294 10517 84261 81035 26224 54461 1213 1211 929 4360 945 3309 811 11314 821 640 5493 7220 3385 3384 30835 9341 8907 130340 3105 567 10053 7879 1174 8905 162 164 5698 5699 3688 5696 5720 5721 7322 997 7334 7335 5588 7189 10235 7087 23118 3695 6279 6280 3689 3386 7534 3685 8453 7498 51466 4690 55740 7408 5930 5476 3693 8673 375 1785 51128 9871 9632 10427 5289 10802 10484 30849 7332 5071 83737 8651 154881 23608 118788 6478 50852 7325 6477 131405 283807 221687 79654 51088 9616 90678 7318 10273 7317 56658 7319 10533 3093 22888 9870 7336 150726 10425 64718 118424 57630 23295 55336 3146 7327 7326 197131 9867 7328 4734 10422 54926 9520 65264 10193 10075 93611 127247 401036 79791 55585 57520 89910 3798 3799 51665 7337 51666 26091 55905 63891 63893 142686 57531 142685 55236 51676 142689 223082 22954 91694 10293 9666 51320 11119 80204 10616 11118 57542 696 7320 56244 51444 11146 11120 135892 10385 55008 153579 10384 6047 79908 6049 23376 23014 57674 143279 25793 84231 11275 89122 3710 9320 55819 64410 90025 222235 84937 80228 140691 51465 54850 140456 140458 90933 140459 90135 25897 25898 9690 146330 84876 140460 140461 140462 3937 255488 114088 7535 27040 54620 23352 9398 868 2533 8916 3702 115290 6737 7704 55958 8139 390594 127544 6786 55284 84961 27246 8924 10768 122769 3708 8925 3709 64320 5566 9354 81559 55175 84708 7174 27252 51130 642 51132 26046 9903 9246 4591 25847 158506 92369 55182 126433 26259 64219 7064 23304 201456 80028 144699 899 84861 92912 10477 26268 55070 90293 84727 92591 26263 26267 53339 10489 285231 933 89890 4012 9820 26235 26118 79176 26232 55521 84085 4008 9817 51725 9039 26249 25831 8065 55658 930 140739 975 51619 9040 148581 79876 79754 84541 9730 154214 51191 151636 80176 23194 7428 9604 136371 5335 10324 8773 1536 1535 4688 4689 718 8678 29127 653361 6402 1525 926 120425 4267 54210 22863 909 7454 22914 56253 56654 89858 910 911 912 4068 3803 3804 3805 3806 374383 2209 8778 925 10666 3802 285852 23547 2214 29121 10990 4345 10871 10870 3811 27180 3812 27181 5336 353514 114836 124599 117157 2213 342510 3820 946 6850 3821 3824 695 126014 100132285 340205 10219 146894 57823 10859 11024 11027 11026 7097 7096 959 135250 131450 9436 9437 259197 79168 29992 29990 10225 89790 4277 114132 51348 11126 11006 339390 100131439 3635 3107 9976 100507436 3106 80329 79465 3903 3904 79865 27036 3134 146722 3133 10288 6614 196500 3135 3683 55824 10333 3676 2923 23327 55860 51164 10671 93661 84516 5788 8767 4615 54209 200845 7305 5909 114609 948 6271 84676 11059 22920 9861 8454 6233 7316 10540 5579 10892 10213 6885 5706 23291 5707 5708 5709 1147 84433 5700 5701 5702 5704 5705 4790 5682 5683 4792 5684 4793 5685 4794 5686 5717 5817 114907 5718 5719 8945 5819 11047 9371 5713 5714 7979 5690 5691 5692 5693 5694 10121 7311 5970 5695 7314 6500 3551 5687 5688 8517 5689 5966 8915 1514 1513 3797 1515 9021 11127 11258 3383 7412 51529 7321 8881 64682 11065 10437 8697 7324 10393 29945 27338 29882 246184 8519 996 51434 51433 5795 6456 1499 30011 999 5728 4893 6654 3265 5906 7529 2033 23643 7099 4780 1387 1509 4772 4773 25780 5534 2280 4775 54778 808 5478 5530 5532 10125 24137 1759 3725 285643 9978 6712 26052 7323 80196 26191 8452 84078 64750 55176 9902 6890 6892 1019 6891 595 29927 6810 23480 50489 10952 51343 830 6502 832 829 27071 8655 1062 991 64167 51143 57154 1520 51752 5641 1508 6396 1781 1780 1778 81930 23108 84643 6494 3796 2244 64837 1783 2266 26153 147700 1512 1510 10112 1519 5519 8722 9493 5894 10120 3831 2243 3832 3835 83547 5908 140735 972 5515 56992 89953 11004 5516 3112 5518 3111 114876 3902 3109 22872 3108 9554 5525 5526 5527 5528 5529 1075 4297 1460 1459 1457 4609 5931 8405 915 10413 916 917 3091 4067 94239 9070 920 4613 11160 4751 9402 253260 57761 29126 142678 51422 3659 5294 5295 5296 5058 1493 5290 5170 5291 5293 54145 58505 940 941 942 6932 6934 58508 5063 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 1029 1021 1019 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs 5743 240 246 239 PHOSPHO-PLA2 PATHWAY%REACTOME%R-HSA-111995.3 phospho-PLA2 pathway 5321 5594 DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME%R-HSA-3656234.4 Defective HEXA causes GM2-gangliosidosis 1 3073 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants 5156 TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P 6888 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373076 Class A 1 (Rhodopsin-like receptors) 727 718 1234 6915 4852 146 147 148 1908 9287 3363 3362 3361 1906 3360 59340 153 2652 154 5443 155 4157 3358 1910 3357 3356 1133 3355 1816 83551 1815 1814 1813 4161 1812 134864 319100 134860 57105 9038 1132 3354 1131 3352 4160 3274 3351 1524 4159 3350 1129 7252 1128 3269 11255 4935 1081 136 6387 10800 51083 7852 729230 1230 10663 1240 56670 1238 719 1237 1236 1235 1233 1232 170589 4985 4987 5956 3792 5729 27198 27199 5739 2587 1901 5732 351 4886 5733 5734 4887 10850 4889 2359 1269 2357 1268 2492 3579 4986 3577 4988 2488 56477 5995 4543 4544 5660 6751 5540 6752 5539 116512 338442 54886 643 6755 6754 301 8811 151306 163404 8843 5697 256933 79948 7504 10692 9934 5473 4142 8862 51052 9718 4283 6346 4158 5368 10563 6351 6352 6354 6357 6356 6348 6349 5030 6361 6364 6363 53829 6366 6367 6360 1903 6373 6372 6374 6376 6370 134 135 5173 5179 9890 6750 64748 150 140 151 51554 152 58191 8698 7253 2919 53637 2921 2920 221391 8484 11251 23596 186 187 165140 2826 2834 2833 4295 2832 7200 2831 7201 122876 56413 1880 5031 57007 5032 283869 2841 1909 57486 2853 94233 2852 2798 10803 2797 2859 2796 50865 1907 1889 5028 5196 2861 84432 9034 5029 64805 1902 9283 6375 3972 1241 3973 2693 9290 6010 84109 9294 10874 1325 29933 2532 3627 10887 5724 10886 257313 5731 5737 6288 387129 2358 8111 8477 2922 6846 2925 10161 6863 183 185 623 624 56923 6870 2151 23566 2150 2149 2147 6865 2829 2828 6866 6869 885 886 887 2837 347148 9002 57121 338557 3814 10911 2840 2846 594857 64106 6347 6753 3827 129521 128674 2867 2865 2864 2863 2862 60675 4922 4923 8620 680 27334 84634 3060 5367 23620 3062 3061 10316 4828 4829 9170 84539 2847 5020 551 5021 552 553 554 27202 3576 728 51289 3640 10022 122042 117579 6019 339403 59350 611 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes 127124 23545 51382 533 534 535 10312 50617 9296 653361 4353 6556 4842 4843 245972 245973 155066 4025 9114 51606 5880 9550 1536 523 1535 4846 525 84329 526 527 528 4688 529 8992 4689 90423 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9754678.3 SARS-CoV-2 modulates host translation machinery 6222 6224 6218 6217 6230 6231 6234 6235 6191 6193 6192 6194 6227 6229 6228 3921 6232 2197 140032 6201 6203 6202 50628 6632 6628 6210 79760 54960 6634 51065 6633 6205 6636 6204 6233 6635 6207 6637 6206 25929 6209 79833 6208 6607 6188 8487 6187 6223 11218 6189 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME%R-HSA-9931512.1 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 1387 4297 406 9575 EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%3928664 Ephrin signaling 8440 5879 6386 5062 1949 1948 5058 2048 1947 28964 10627 8874 2051 2050 2049 2047 2534 5063 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation 176 89944 4060 2799 5549 2588 2331 112937 3074 3073 4969 79411 4958 2720 11081 MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 96%9022927 MECP2 regulates transcription of genes involved in GABA signaling 2571 2572 DEFECTIVE CUBN CAUSES MGA1%REACTOME DATABASE ID RELEASE 96%3359463 Defective CUBN causes MGA1 8029 81693 2694 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-HSA-8878159.4 Transcriptional regulation by RUNX3 5708 7004 5709 7003 5700 4088 7005 5701 4089 5702 5704 5705 5682 861 5683 865 5684 10018 64750 8463 5685 3280 5686 5717 5718 5719 8850 11047 5713 2309 5714 9794 7979 5690 6046 5691 5692 5693 7040 5694 7311 1499 4851 5695 7314 5687 4193 5688 6714 595 1490 5689 10046 3683 1026 463 9759 6696 1029 3676 22938 84441 2033 4609 10413 2648 83439 864 57154 3845 7157 182 51176 1387 25937 9861 3516 6233 7316 10213 6932 5706 6934 5707 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190239 FGFR3 ligand binding and activation 2249 2247 2246 2591 8823 2254 8817 26281 8074 ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism 5743 240 145482 873 2166 5444 27306 5445 10728 5446 5730 3248 4048 6916 247 5740 1582 9536 1558 1557 127281 1544 1543 158833 1573 1559 9261 2053 4051 4363 11283 8644 22949 4056 126410 1580 241 57834 246 284541 376497 2877 5321 2678 80142 64174 2687 242 59344 2879 1800 1579 1545 113612 239 8529 2876 158584 5742 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%1250196 SHC1 events in ERBB2 signaling 5782 2064 1956 4893 6654 3084 5581 3265 9542 5580 10718 145957 6464 685 1950 2069 5578 1839 MAPLE SYRUP URINE DISEASE%REACTOME%R-HSA-9865114.1 Maple Syrup Urine Disease 152926 594 1629 1738 593 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 96%141334 PAOs oxidise polyamines to amines 196743 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 96%5579014 Defective CYP27B1 causes VDDR1A 1594 SIGNALING BY EGFRVIII IN CANCER%REACTOME DATABASE ID RELEASE 96%5637812 Signaling by EGFRvIII in Cancer 867 1956 4893 6654 3265 5295 3320 5290 5335 2549 6464 1950 11140 MRNA CAPPING%REACTOME%R-HSA-72086.5 mRNA Capping 2963 22916 2962 2068 5434 5435 4686 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 5440 5441 8732 4331 8731 1022 2071 6829 2966 2965 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters 808 64924 7922 55630 1356 6543 283375 29986 283652 29985 169026 80024 1317 64116 84679 6550 6553 389015 6546 55532 6548 6556 6549 7781 6547 10479 285195 7780 23315 9187 25800 4891 7779 30061 254428 57419 25769 23516 57181 6717 123041 9843 84102 27173 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%210990 PECAM1 interactions 4067 5335 3932 3690 5175 2534 3685 7525 5781 5777 3635 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter 10621 5434 6908 5435 5437 51082 84265 55703 112495 11128 51728 9533 9330 27297 661 2976 5440 10623 5441 2975 2972 171568 55814 9328 9329 55718 10622 G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK 695 55970 2793 2792 2791 2790 2788 2787 2782 2786 54331 2785 59345 2784 2783 10681 51764 94235 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020591 Interleukin-12 signaling 5478 4507 3593 3592 5062 7297 4001 375 5908 6845 6888 3458 6648 9987 654483 27250 302 4478 1265 9446 5306 9049 6775 3716 6627 3936 5034 4282 5721 759 5055 3595 3594 6175 6950 5898 6647 1072 2939 3313 829 3717 3181 998 3586 3185 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters 6561 26266 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME DATABASE ID RELEASE 96%9837999 Mitochondrial protein degradation 384 4200 4722 4191 56910 6770 4719 51079 38 3158 4712 622 5019 4976 56652 115209 6742 4508 217 27166 498 1891 3033 219 3313 10965 5096 539 3329 10476 10632 522 27429 9377 506 9361 509 7019 3028 51499 4967 133686 5566 91689 6687 10939 23203 1632 221154 10730 54995 55173 5832 8192 10845 4512 4513 2746 197257 29928 7385 51142 55699 4723 4731 27089 26519 64983 3419 50 6182 3418 26520 4540 4541 4535 4536 51116 1431 1327 1629 10440 1738 4695 2271 5162 1329 5163 36 27034 8801 292 6472 293 211 5160 2235 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 96%198765 Signalling to ERK5 5607 5598 CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle 8331 8337 8334 51400 8335 51451 90381 79596 728642 984 63943 79866 51512 8341 8342 8347 55320 8348 8345 201254 51773 55355 11339 387103 8340 54069 23649 8338 5422 85236 8349 5557 5558 25946 57060 64326 2932 11200 51230 91768 7465 286826 114799 8370 132660 91750 1163 5753 55957 157570 3013 255626 3021 3018 3017 3014 9985 474382 27127 10734 10000 50511 93426 10388 8970 128312 23345 23224 256126 56158 6847 55766 644186 23353 8968 7532 8467 207 208 653604 5577 5928 3978 113457 140609 10783 91754 7280 1263 10376 80086 51807 10381 10383 10382 112714 55135 7846 84790 84617 22822 11144 23626 347733 25777 29893 27030 84057 7277 4438 7157 4439 3161 7278 81027 79861 9883 129401 9688 23225 4927 23165 55706 23636 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 8815 84515 5000 5001 23594 23595 4998 6790 4999 10133 2305 7153 4149 80119 55164 54921 63922 10856 80169 79075 79991 100134934 10142 56979 3320 3837 7840 5578 11064 22994 9656 22995 8317 7283 203068 10776 55722 1453 79648 5862 9738 255919 84930 11190 2029 55844 5901 54892 23310 25836 95681 23383 27436 8548 23399 29781 1069 26003 9861 8454 6233 7316 54801 10540 5579 10213 4218 5706 23291 5707 5708 11116 5709 5700 5701 5702 27183 5704 5705 54930 5682 5683 5684 79959 2810 5685 5686 5717 93323 5718 5719 22981 8945 11047 5713 5714 7979 80254 5690 55755 5691 10806 5692 5693 5694 10121 7311 5695 7314 6500 9662 5687 5688 5689 7341 10733 80321 55125 9814 3930 115106 51588 79441 7329 9702 3842 5108 7486 5981 5982 55142 5983 22897 3364 472 56655 5116 672 675 80184 84126 144715 83990 5810 5932 3306 9156 5111 23354 11073 8481 641 55732 6117 5984 5985 121441 5424 6119 5425 55559 6118 1454 5426 8636 7015 1452 5427 11258 79858 84131 5883 5884 116028 4957 10714 1111 83695 10111 8468 57804 4361 7156 9232 4683 580 5933 63979 5934 10524 4659 1763 4605 545 51750 54107 5888 80010 5889 51529 7321 8881 64682 25906 1104 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 983 7443 996 9798 22933 51434 51433 221496 5347 200014 2010 9700 260334 6683 347688 22974 23141 85378 64151 4869 10426 10592 29922 27229 9918 7334 23397 440145 80097 10051 4926 114791 27175 23592 653784 10844 1432 9663 5594 7534 10971 7533 5600 7529 3065 64900 23175 5500 2033 5520 7514 1859 7298 28227 7083 1719 26271 4001 7531 2801 993 994 3326 995 4172 4173 4174 4175 4176 64785 8318 9837 84296 4171 9978 51659 6241 25 92421 8607 27243 128866 79643 51652 9088 29082 7336 7027 1021 91782 1019 595 1017 25978 894 55835 896 29935 1871 10926 81620 898 1870 51343 2237 6502 51053 1616 55388 9134 1028 1027 1026 546 7029 1869 5925 54908 6232 8655 25909 8379 9183 23047 1063 1062 9184 1060 991 7468 151648 29086 1876 55166 9025 1058 1875 51720 79019 1874 151246 63967 9735 23332 84142 165918 79003 7158 55055 81565 22919 113130 9577 348995 79184 348235 9126 5048 23421 57122 220134 57082 57405 147841 51143 6249 55746 387893 4085 9133 64105 84962 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 1781 23122 23244 1780 79172 1778 81930 10735 55920 84643 3796 9793 91687 57551 79682 3717 5905 1783 5501 83540 80152 5903 2491 10112 5519 332 55143 9493 23063 699 8924 11243 10274 140735 3619 5515 5566 11004 5516 5861 5518 23243 9212 25936 8243 26277 11130 25913 64946 79980 10726 5537 79902 5885 5525 5526 64689 55839 5527 5528 55291 5529 4194 4292 80028 890 4193 8615 54386 81876 8290 5440 5441 6418 7013 65057 4331 7014 1022 1032 1031 1030 1029 5434 5435 5436 5437 5438 5439 8900 5430 5431 5432 5433 23194 902 1460 990 1459 1457 1736 4609 5931 55505 4067 94239 4751 54433 55651 8556 54145 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) 6514 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 96%162599 Late Phase of HIV Life Cycle 92421 23636 9972 9631 27243 7175 11097 128866 23511 8086 8021 10015 53371 8480 1104 10762 5902 4836 79643 51652 29082 91782 25978 348995 57122 55746 7514 23279 79023 6396 5901 6233 7316 5905 9525 8178 129685 51160 6872 55048 22916 89853 5903 5478 6874 6873 6908 155382 4686 137492 27183 6827 6749 93343 6881 7251 6880 51271 6883 79720 6882 6884 51510 8148 51534 9150 6917 1025 51497 11198 6875 6878 83860 6877 8812 79902 2959 2958 6879 2957 25920 54457 2961 2960 7311 51224 6921 6924 7314 5045 7936 6923 7469 138474 904 905 5440 5441 8732 4331 8731 1022 2071 6829 2966 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 9397 23327 9883 129401 9688 23225 4927 23165 55706 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855170 IPs transport between nucleus and cytosol 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 10762 348995 79902 57122 55746 23279 79023 6396 9883 129401 9688 23225 4927 23165 55706 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 96%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA 55526 1738 1743 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69273 Cyclin A B1 B2 associated events during G2 M transition 5519 51400 151648 51451 90381 79596 8900 5515 79866 5516 993 5518 994 902 891 55320 995 983 55355 5520 5347 9088 7514 9133 890 1017 28227 2305 51343 7465 4331 1022 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013425 RHOT1 GTPase cycle 66008 5910 22906 55288 80179 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation 3912 721 718 10618 1462 813 255738 51246 462 54757 8404 8542 29106 5034 3491 3895 3488 1471 3487 64856 10117 116519 1114 258 7857 10232 5768 5954 56955 4240 1758 2621 4241 197 3270 213 3371 265 336 401138 51156 147111 51280 56975 3956 2200 4924 3053 8614 2519 375056 7076 5624 10272 174 80341 54972 4148 3698 1435 84141 9210 11098 54587 4052 6694 334 11320 5611 335 3827 338 4221 7184 5589 6383 2266 2243 351 5265 10130 2153 3490 57719 7425 7466 91851 11167 6696 3569 1356 2719 57104 652 7018 348 1000 5179 3486 3484 102 10970 8074 8720 3913 3915 2335 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism 5743 11000 240 54898 5538 197322 51703 6785 22880 9374 2182 3293 81616 117145 2181 51495 7923 109703458 6916 5740 1582 5264 1384 23600 283927 55289 5467 54677 79966 390916 26063 1962 122970 215 11001 3295 30 10005 51179 8310 9261 6584 2053 51102 55825 6296 8309 35 1892 6342 3033 142827 10965 91452 5096 4051 4594 4363 84693 26061 11283 166785 8644 22949 5095 4056 126410 1580 241 83401 1374 57834 246 284541 376497 5563 5565 5321 2678 80142 64174 2687 1800 1579 1545 113612 8529 158584 2876 1376 1375 58526 5742 284486 80221 145482 873 2166 55856 5444 788 5445 27306 5446 10728 11332 5730 80724 3248 10449 84320 4048 247 414149 34 1666 1632 9536 2194 9415 84129 1558 3992 1557 127281 1544 23597 79777 1543 641371 134526 158833 1622 1573 27349 26027 58488 1559 6256 37 2877 60481 7069 33 3032 3030 2180 4706 10478 6319 79071 242 59344 31 2879 51422 9200 47 9524 64834 239 401494 23205 23305 79993 84869 253017 201562 51144 55301 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702620 quizartinib-resistant FLT3 mutants 2322 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME%R-HSA-3560783.4 Defective B4GALT7 causes EDS, progeroid type 633 1464 6382 1463 3339 10675 2719 221914 2262 9672 11285 1462 2239 2817 63827 1634 6383 10082 6385 375790 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-HSA-176408.6 Regulation of APC C activators between G1 S and early anaphase 5708 5709 5700 51529 5701 7321 5702 5704 8881 64682 5705 25906 11065 5682 8697 5683 7324 5684 10393 29945 27338 5685 119504 5686 29882 5717 891 5718 246184 5719 983 996 8945 11047 51434 5713 51433 5347 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 6500 890 5687 5688 5689 1017 51343 9184 991 8900 4085 701 26271 9861 8454 6233 7316 10213 5706 5707 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 96%445989 TAK1-dependent IKK and NF-kappa-B activation 1147 4790 4792 351 4793 841 7186 3654 8767 4791 7311 5970 7314 7157 3551 84166 10454 6285 7334 8517 6288 7335 11274 7189 64127 6283 257397 3146 23118 9683 9684 10392 28512 79671 6233 177 121457 7316 28511 3656 6885 9097 80216 92610 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 96%8964572 Lipid particle organization 1149 29923 161247 128486 345275 63924 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 96%399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 2892 817 2890 818 80852 9463 2893 4646 2891 2036 5578 27092 7102 23426 4193 4905 160 10369 10368 5582 59283 5579 1742 9495 1739 815 816 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression 30818 23112 57690 266743 192669 192670 27161 26523 6722 2908 5978 27327 4343 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 96%5676934 Protein repair 253827 51734 7295 22921 4482 5110 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint 80010 8924 7531 8341 2810 8342 8347 995 8348 891 8345 983 8340 85236 8349 7336 890 7334 11200 7465 8370 8290 7534 10971 7533 51588 7529 7486 255626 7468 29086 9025 5982 5983 51720 3364 8900 472 672 84142 165918 84126 7158 144715 3018 83990 3017 5810 3014 9577 79184 5932 9156 11073 641 8970 128312 6117 5984 5985 6119 9656 6118 7157 7532 5883 5884 116028 1111 83695 10111 4361 7156 54145 4683 580 10524 1763 545 DEFECTIVE CBLIF CAUSES IFD%REACTOME DATABASE ID RELEASE 96%3359457 Defective CBLIF causes IFD 2694 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate 5424 6119 5425 5557 5558 6118 10714 2237 57804 5111 23649 6117 5422 1763 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%9623433 LXRs regulate gene expression to control bile acid homeostasis 7376 10062 6256 9612 2172 6257 8648 54659 9611 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380259 Loss of Nlp from mitotic centrosomes 11116 7531 54930 5566 79959 5518 93323 983 22981 5347 80254 55755 10806 10121 9662 55835 10733 80321 55125 9814 115106 8655 79441 9702 5108 55142 10383 22897 10382 10142 5116 23332 80184 3320 22919 7846 5048 23354 8481 7840 11064 121441 22994 22995 7283 7277 55559 203068 1454 8636 55722 4751 11258 1453 7532 54820 84131 9738 11190 4957 1781 95681 1778 1069 5577 9793 54801 10540 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 96%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 29028 7422 3815 2064 94115 1956 7039 7022 7021 2099 7528 7020 1081 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein 3276 1452 2932 7341 6733 6732 54956 143 2931 56965 83666 79668 84875 54625 7329 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars 84912 51000 7355 55343 23169 10559 11046 347734 23443 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes 8720 10488 51360 84699 153222 90993 64764 81501 148327 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 96%8949664 Processing of SMDT1 286097 90550 91689 6687 9512 10939 23203 55486 55013 79568 221154 5245 11331 30968 10730 10367 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma 5335 374 1956 7039 685 1950 255324 2069 1839 PYROPTOSIS%REACTOME%R-HSA-5620971.6 Pyroptosis 92421 3002 27243 3553 128866 834 837 838 79643 51652 54205 3606 3660 79792 578 1991 29082 7157 8626 91782 3552 25978 581 1687 3146 3659 836 BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations 26 66002 6916 5740 1582 23491 54659 373156 196743 5443 1589 1585 8648 2678 64174 10499 4129 2687 1800 7172 2944 23169 1579 10 1545 9 113612 8529 11046 2939 10941 133688 54490 79799 55347 2938 54658 54657 7358 7363 7365 7364 7367 9915 7366 54600 134147 54578 54577 670 54576 54575 218 7360 574537 54579 167127 10728 10720 2052 314 8639 13 3326 874 4835 54996 64757 2328 2327 80777 95 80146 4143 4144 4552 9446 191 4837 1312 29104 9971 9420 27430 1593 57412 1581 51504 4548 10249 123876 341392 1595 219970 92292 54988 389396 405 54928 6783 10380 391365 25830 6818 6817 8574 84836 22977 6819 27284 124975 2326 445329 2686 91703 27233 6799 4257 50512 4258 6822 4259 246181 216 10327 10858 1594 124 125 1584 51302 84532 126 5447 127 128 217 55902 219 130 131 1066 4051 11283 126410 1580 1592 57834 284541 56603 340665 285440 9049 1591 4128 2940 2950 1727 2729 2730 5742 79094 26873 2098 653689 27306 2941 79017 55748 2949 2948 8460 2947 2946 1572 221357 1571 2954 64816 2953 57491 196 2952 494143 1558 119391 1557 1577 8459 1555 1544 1565 1543 1576 1553 29785 1562 1573 1551 54905 1549 1548 1559 116285 348158 6256 120227 1588 112812 2232 2230 1583 8824 2937 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins 6279 6280 6278 4057 338324 3934 HCN CHANNELS%REACTOME DATABASE ID RELEASE 96%1296061 HCN channels 610 10021 348980 57657 RAS GTPASE CYCLE MUTANTS%REACTOME%R-HSA-9649913.5 RAS GTPase cycle mutants 3845 4893 3265 PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-HSA-418360.3 Platelet calcium homeostasis 808 6786 6543 3708 3709 5025 6546 5027 7222 6547 3710 7225 5023 80228 5024 9127 5026 22953 487 488 57113 489 84876 6717 490 491 492 493 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 96%9674555 Signaling by CSF3 (G-CSF) 8065 7321 7297 6772 6774 1441 8651 9616 7311 7323 3716 4067 6921 7314 7322 6923 3845 5781 2885 6777 6776 3055 6233 7316 6464 3717 9846 9021 6850 1440 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases 1297 1293 10787 1292 2353 1291 1729 8936 5062 117145 10152 2185 1287 14 3071 5155 10163 8874 653361 2354 2475 10006 1786 5879 5156 160 9564 161 163 79109 5663 3791 5664 5781 55851 83464 23385 51107 3416 9844 5753 2277 1175 998 1173 5777 5340 55615 5567 5568 6772 6678 6774 7424 7423 4318 10810 3932 64223 10000 3727 2886 7525 222584 207 208 7409 8503 26999 1495 2534 1445 22916 3630 4686 3718 5725 3561 4670 10608 25920 11033 80310 7059 3925 2321 7060 8483 1447 6938 81610 10252 5796 26018 84985 55824 3178 3187 3185 3084 2562 2561 2560 6722 2554 5228 3315 2567 2566 55879 5774 639 8877 6692 8038 3249 4485 4486 10653 25942 64759 84951 85440 3730 1213 1211 7422 4205 6285 3066 558 5771 4145 26469 2323 466 51231 1849 1848 1846 1845 54845 3320 5578 11059 238 6233 7316 5579 1956 7039 5800 7057 7311 7314 1003 5241 2099 3726 9542 3400 51072 10718 145957 51741 5829 1958 5590 387 1111 9252 23543 3913 80004 3914 7073 3915 7072 2670 3918 284217 10319 3908 3909 3910 3911 3912 5803 3688 1108 5795 9146 6456 4233 8027 63916 6455 2060 1500 1499 1793 30011 23163 6457 867 10254 6714 6014 4893 6654 6016 3265 23191 9261 23118 2889 673 1399 6195 1432 1398 55914 5898 5899 4803 25759 5594 5595 5867 6300 5978 6464 10818 4914 5906 57498 5600 53358 7867 1959 5900 7529 3065 5603 5604 3815 5605 5770 2033 3397 8471 3481 3479 3480 3685 5747 8440 857 6387 53916 4208 4209 7410 8841 9611 2885 4690 6777 6776 1386 10451 8829 1509 11140 4192 808 2324 23767 6093 2064 8851 7166 1020 6236 2152 4066 9475 8941 3398 5607 429 10126 3399 8828 8061 10221 1759 4664 4665 23237 1961 1960 7425 5045 5046 5125 9306 26052 116 117 685 255324 2069 2002 6696 1839 5782 10048 2591 6446 23768 23769 7058 348 1785 200958 10253 8569 3083 135 5140 9965 5289 2254 2252 2251 27006 8074 2249 2248 2247 2246 152831 8823 8660 30849 2264 2255 1742 54106 9846 3667 8817 26281 3673 3675 161742 200734 5921 83737 8651 5159 4916 7006 10019 1215 10076 10750 2242 2241 10603 10273 581 4734 57610 10193 7049 2322 10755 285016 389658 5764 5580 9101 3710 4846 9047 6461 2887 3643 3717 5519 3690 10768 3708 6778 3709 5908 5515 5566 6197 5516 6196 5518 5528 245972 245973 4058 155066 10188 9114 51606 9550 523 5440 5441 525 526 527 528 5327 5598 529 8992 90423 2963 127124 2962 23545 8065 51382 5434 5435 533 5436 534 5437 535 5438 5439 537 10312 5430 5581 5431 50617 5432 7074 5433 4915 1795 4908 9296 10817 4909 5792 5335 627 2904 2549 4609 374 1950 10413 53834 29924 3091 4067 4613 382 9402 102 3082 253260 5802 57761 29126 6868 9982 143282 1286 58513 1285 83888 5295 256076 1284 5296 1282 5058 5290 5170 5291 1536 3728 1535 1299 10458 1298 4688 55845 4689 131873 5063 SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET 3910 3911 3912 3673 3675 5908 64759 3688 84951 85440 9146 5795 6456 4233 8027 6455 2060 7311 30011 5879 7314 23163 6457 867 10254 6714 4893 6654 3265 5781 2889 26018 1399 1398 57610 5771 5867 5906 10048 6774 5770 2549 200958 9101 3083 5747 53916 382 3082 5295 5290 3913 6233 3914 6692 3915 7316 3249 3918 284217 10653 10319 3908 3909 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 96%9028731 Activated NTRK2 signals through FRS2 and FRS3 10817 4909 627 4893 6654 10818 3265 5781 4915 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 819 6449 23480 6844 351 27230 10952 7485 6804 9381 5621 7917 6811 439 3162 9218 51608 8266 2010 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174411.6 Polymerase switching on the C-strand of the telomere 54921 63922 80169 5981 79075 5982 79991 5983 100134934 26277 25913 5111 23649 5422 5984 5985 5424 5557 5425 5558 54386 10714 57804 7013 65057 7014 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 1019 595 2932 5689 9861 6233 7316 10213 5706 5707 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME%R-HSA-9918449.1 Defective visual phototransduction due to STRA6 loss of function 64220 5950 7276 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 96%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) 2645 ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 96%9914355 Isovaleric acidemia 3712 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9828642 Respiratory syncytial virus genome transcription 3312 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 96%187042 TRKA activation by NGF 4803 4914 DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 8460 2157 8459 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide 23632 759 768 377677 761 763 765 766 760 11238 762 771 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9909438 3-Methylcrotonyl-CoA carboxylase deficiency 64087 56922 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 96%2408552 Methylation of MeSeH for excretion 11185 BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME%R-HSA-2466712.4 Biosynthesis of A2E, implicated in retinal degradation 222236 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) 6523 DRUG ADME%REACTOME DATABASE ID RELEASE 96%9748784 Drug ADME 124975 445329 2686 27233 6822 5879 54659 124 213 1066 4363 161823 4860 132 100 22978 6581 5243 3704 2678 2687 64078 7498 7410 55270 3177 9153 3251 7172 2950 7409 2030 3615 2944 3614 2987 10 10451 9 4830 10941 2939 133688 8714 4831 54490 8833 79799 10057 2938 10257 54658 54657 7363 7365 7364 7367 7366 54600 54578 54577 54576 5444 54575 574537 54579 167127 5446 10720 55748 1571 2952 1558 1557 1565 1576 3291 3290 866 1559 348158 9429 5105 10599 95 6566 682 28234 55315 590 10249 1645 123876 341392 219970 92292 8824 54988 389396 9376 6579 6582 6783 6580 6818 6817 1244 RUNX3 REGULATES WNT SIGNALING%REACTOME%R-HSA-8951430.3 RUNX3 regulates WNT signaling 83439 1499 864 595 4609 51176 6932 6934 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.5 Loss of Function of SMAD2 3 in Cancer 4087 4088 4089 7046 7048 7040 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9603381 Activated NTRK3 signals through PI3K 4908 5290 4916 6714 3667 5295 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly 3691 1308 667 3655 3914 3918 977 3909 5339 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 96%380615 Clearance of seratonin 6532 217 4128 CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle 5467 6256 1374 788 5563 1376 51422 1375 6584 58526 7069 5565 NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%8956320 Nucleotide biosynthesis 158 159 5471 5198 7372 3615 122622 3614 1723 10606 2618 8833 471 790 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6793080 rRNA modification in the mitochondrion 51001 55178 79922 130916 84881 285367 29960 387338 22868 26995 51335 81554 51106 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME%R-HSA-5619108.3 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) 10999 SIGNALING BY FGFR2%REACTOME%R-HSA-5654738.4 Signaling by FGFR2 22916 4686 5515 5516 5518 5725 4670 7311 7314 867 4893 6654 3265 5781 673 5440 5594 5441 5595 3178 10818 3187 3185 2963 2962 5434 5435 5436 5437 5438 5439 5430 5431 54845 5432 5433 10817 5335 2549 10253 8569 2254 9982 2252 143282 2251 27006 83888 8074 5295 2249 2248 2247 2246 5290 23543 8823 80004 6233 7073 7316 7072 2255 8817 26281 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%419408 Lysosphingolipid and LPA receptors 23566 9890 64748 8698 1901 54886 53637 57121 163404 9170 79948 1903 1902 9294 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 96%162791 Attachment of GPI anchor to uPAR 51604 10026 5329 128869 80055 8733 94005 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 96%5387390 Hh mutants abrogate ligand secretion 6400 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 50846 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 10956 7311 5695 7314 84447 5687 5688 5689 55733 7415 27248 3549 9861 6233 7316 10213 6469 5706 51009 5707 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%937061 TRIF (TICAM1)-mediated TLR4 signaling 7321 2353 841 8737 329 11035 7186 8767 4791 330 7322 84166 4205 10454 7334 6285 7335 929 6288 7187 11274 9641 7189 64127 353376 6283 148022 3146 257397 5781 10010 9261 10133 23118 9683 9684 6195 1432 10392 28512 79155 79671 5594 177 5595 121457 28511 3656 9097 466 5600 51231 1849 7867 1848 1846 1845 5604 23643 4208 7099 1386 8454 6233 7316 1326 6885 23291 80216 92610 1147 5519 3665 4790 351 4792 5515 6197 6196 4793 5516 5518 8945 3725 3654 5528 7311 5970 7314 6500 3551 8517 5608 5609 6416 5601 5602 5606 5598 2002 5599 29110 3661 7323 7157 9252 8772 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 96%163210 Formation of ATP by chemiosmotic coupling 539 518 10476 10632 9551 9556 84833 521 522 506 509 27109 4508 4509 498 513 514 515 516 517 SIGNALING BY GSK3BETA MUTANTS%REACTOME%R-HSA-5339716.5 Signaling by GSK3beta mutants 1499 5519 1452 139285 2932 5515 324 5516 5518 8312 5525 5526 5527 5528 5529 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME%R-HSA-9032845.3 Activated NTRK2 signals through CDK5 5879 627 8851 1020 7074 4915 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170984 ARMS-mediated activation 1398 7529 4803 4914 5906 57498 673 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-HSA-947581.2 Molybdenum cofactor biosynthesis 55034 10243 4338 27304 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing 8106 10898 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD 4143 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-HSA-174184.3 Cdc20:Phospho-APC C mediated degradation of Cyclin A 5708 5709 5700 51529 5701 7321 5702 5704 8881 64682 5705 25906 11065 5682 8697 5683 7324 5684 10393 29945 27338 5685 119504 5686 29882 5717 5718 246184 5719 983 996 11047 51434 5713 51433 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 890 5687 5688 5689 9184 991 8900 4085 701 9861 6233 7316 10213 5706 5707 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 96%5263617 Metabolism of ingested MeSeO2H into MeSeH 7296 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 96%8983711 OAS antiviral response 4939 8638 6041 6059 201626 23586 4938 2316 4940 VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways 8331 8337 8334 8335 5062 100128731 8341 8342 8347 8348 8345 8340 2475 8338 85236 8349 5879 5034 6185 23476 6184 160 161 2932 746 163 79109 1603 81608 5781 8370 2146 1175 1173 5777 3013 3069 55615 255626 84061 6772 3018 3017 3932 7991 64223 201595 10000 3703 8970 128312 3716 1650 8726 8968 7518 7532 207 3981 208 7409 653604 7415 5133 23512 5928 6383 2534 10082 6385 8178 129685 6872 22916 6382 6874 6873 6908 4686 3718 6827 6749 3554 7297 6881 79685 6880 6883 8819 1901 6882 6773 6884 221914 3460 8148 9672 29760 9150 6917 3459 1025 51185 973 51497 11198 23186 2239 974 6875 3454 6878 51742 83860 6877 10280 8812 10284 2342 2959 64426 2958 6879 25855 2339 2957 25920 5926 54457 10362 51317 2961 8189 2960 11051 51224 6921 10978 1479 6924 3339 7936 51692 1478 6923 1477 7469 23283 138474 904 10914 53981 905 51585 2697 29894 55339 2262 2817 2719 9883 129401 26007 9688 291 292 293 23225 3836 4927 3159 23165 375790 11168 55706 23636 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 8815 6230 23168 6231 79577 6234 9349 6235 6191 80349 7040 6193 6192 6194 10898 123169 1213 51121 9646 1211 6227 6229 929 6228 54623 11224 7187 9641 200916 6122 6124 6123 6125 7301 2621 25873 140801 558 4360 197259 3921 22924 4736 440400 6130 9076 6133 4061 6132 51234 10461 6135 6134 945 6137 3309 5627 6136 57504 811 91937 11314 6128 9636 3192 6129 9112 6142 6141 6144 6143 6146 6147 142 3304 821 6139 6138 6152 6155 6154 6157 6156 6159 6158 3320 2197 23521 2589 3837 54956 140032 143 3838 2931 3839 5610 63982 56965 5611 83666 6164 79668 6166 84875 203859 6165 54625 6168 6201 6167 8106 5593 6203 6169 6202 116832 57101 6160 6161 2633 402569 3840 3841 3843 5901 6175 9045 338440 6210 6176 6171 6170 6173 51065 6205 6204 6207 6206 2926 6209 6208 6188 6187 6223 9525 51160 6189 55107 55048 6222 89853 6224 11267 6181 51028 6218 155382 6217 137492 27183 93343 7251 51271 861 79720 84313 51510 51534 55129 50636 2194 7284 196527 57719 121601 9785 6430 6432 6431 10250 51362 199746 6427 6426 6429 6428 10189 8683 9775 9295 10921 11338 7307 9397 1452 30835 7448 8907 130340 3105 567 10053 1174 8905 1104 162 1234 55690 5902 164 4836 3688 1794 10454 7334 7335 7189 257397 23118 7534 7533 64135 3442 3065 3441 3440 23586 5499 80143 84282 57506 3452 3451 3449 3448 3446 3445 3444 5500 3443 7706 6733 6732 4691 3480 1524 5878 5868 5869 857 26986 4690 3615 3614 7852 8829 6093 3183 7431 9475 27316 3326 79869 8813 8818 5045 1977 54344 1981 7113 59272 26762 57521 2002 375 3312 6667 51128 9871 9632 1312 10427 22937 5289 10802 10484 30849 54106 92421 27243 128866 834 10015 3570 83737 79643 51652 8737 11035 7318 7317 10533 29082 91782 25978 2147 55236 476 477 478 53822 89122 53826 53828 480 481 482 483 486 5348 5349 23352 815 816 817 818 9246 1994 9817 9039 8065 3456 79876 1191 51191 722 725 7428 598 1915 10207 92359 64398 50628 6632 6628 79760 54960 6634 6633 6636 6635 6637 25929 79833 6607 8487 11218 440689 721 8678 23479 81631 7405 9844 3055 926 10965 5824 10421 55588 91662 22863 27072 285755 80306 57794 317649 22826 22827 11282 1052 7841 4318 29801 6993 25921 11100 253832 23339 51201 10262 55741 54883 11320 51125 90701 11325 4247 10236 51304 55749 4249 10610 64225 4131 6483 8974 6482 23765 6484 23524 6487 54431 4245 4124 10450 57703 6480 684 25834 689 23193 11311 256435 10465 79844 5479 2530 27090 54463 53938 11253 28972 10800 5589 5033 51114 64601 24148 9868 29108 23020 114548 85313 9879 9410 9412 9416 5336 10181 9685 51340 23478 5093 5094 51593 57461 6850 84844 65082 695 1982 1993 27238 400569 8175 283208 51726 51729 55090 7097 7096 23097 80273 112744 51503 23601 55696 10992 10525 10527 5725 3978 10523 6837 4670 3654 84818 4666 10951 3107 3106 988 10134 6627 6629 220988 3134 3133 9908 81857 23450 23451 56949 5546 6638 10146 219541 3135 10594 25820 550 54797 10332 10333 6441 5356 3178 3181 3188 3187 3185 3184 3676 55666 9716 5119 10313 3191 3190 7555 57617 51639 8896 1024 51645 6238 8672 23389 85437 9532 7353 10084 10291 9789 10294 23367 8449 55823 11123 2923 10283 8241 25777 23350 10286 10285 9343 56259 26276 23327 9111 10945 10946 10949 10907 9360 60559 1654 27339 1665 4939 84991 3605 2521 83443 10025 892 3276 10001 8767 29079 3066 64127 10392 9612 9862 3656 54815 203068 84246 9443 9861 9441 9442 6233 7316 10213 9440 6885 5706 5707 5708 51586 5709 1147 9439 5700 5701 10155 5702 5704 1956 5705 4790 5682 5683 4792 5684 4793 2810 5685 5686 5717 5718 5719 8945 11047 5713 5714 9219 7979 5690 5691 9477 5692 5693 5694 112950 7311 5970 5695 7314 6500 3551 5687 5688 8517 5689 7341 1514 55763 8729 2908 7329 2874 9282 1107 9382 1108 1499 30011 4869 6654 10971 5978 22938 7529 2033 23643 6907 57459 335 7514 51003 79718 54464 7099 4780 8841 9611 1387 5469 23028 2288 6886 2280 1655 5478 7531 10728 9978 5371 9968 9969 29959 8452 4088 4089 53615 2237 1616 1974 1973 5925 6232 90390 8655 4904 348995 57122 317772 51143 92815 55746 85235 8969 221613 23279 7098 79023 51284 51311 4153 6396 1781 1780 712 1778 716 5648 57551 3717 5905 7520 1783 1660 2547 5501 115004 5903 340061 3665 140735 79902 51606 7082 5440 5441 8732 4331 8731 1022 2071 6829 2966 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 404672 5430 5431 5432 5433 902 1460 1459 29110 1457 3661 5931 81030 4067 920 4751 253260 5295 5170 58505 940 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases 808 817 818 57130 6588 540 5205 23400 374868 23120 84239 23250 57205 344905 10396 51248 148229 27032 51076 23200 476 477 478 53822 79895 53826 5350 479 53828 51761 480 481 286410 482 483 486 57198 487 57194 488 489 5348 5349 6717 495 490 496 491 492 493 9914 10079 815 538 816 PACKAGING OF TELOMERE ENDS%REACTOME%R-HSA-171306.5 Packaging Of Telomere Ends 8331 3013 8337 8334 8335 255626 8341 3018 8342 3017 8347 26277 3014 8348 8345 25913 8340 474382 8970 128312 8338 85236 8349 94239 55766 54386 8370 8290 54145 7013 65057 7014 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%111465 Apoptotic cleavage of cellular proteins 6093 839 4001 840 63967 2620 118 7431 4137 28988 324 5339 2934 841 329 5580 2339 660 5747 6709 10134 1499 51765 8428 999 22985 6304 5588 1832 1830 100506658 9414 1829 1828 7082 836 5317 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism 6476 6916 4853 4854 3938 4855 81693 8029 1892 5443 79087 85365 29929 10195 162417 79796 445 9526 435 3417 1373 56052 10166 79053 1798 5009 57407 91869 383 9060 7841 1589 5373 1585 4351 2548 4969 4247 2542 2678 21 2683 6487 4060 2799 22856 11041 11253 1605 3251 11285 7172 2331 378884 23169 1545 113612 6383 54658 10082 54657 6385 2584 2582 130589 6382 2592 2588 3795 221914 9672 440138 22845 2239 5476 10020 79644 5507 2673 22934 8813 2132 2131 8818 4851 176 3339 729238 2328 8908 1836 4669 116150 2262 5091 54344 79947 4758 2817 6441 9469 5826 7957 145173 57188 95 92579 2591 143662 79695 2719 10417 5549 118430 4158 10418 170689 171019 126792 55788 54437 3955 9510 9037 10568 4582 6888 6440 5199 4583 7058 4584 4585 4586 200958 157869 29954 4143 727897 56667 4552 29071 9507 191 80070 10585 140766 9508 9420 1593 9509 10071 94025 4548 339366 221981 79875 81794 6948 140453 55901 31 4588 4589 81792 113189 55624 283463 9719 56999 56913 11093 394263 11173 11096 2998 11095 11174 2997 9215 2632 2992 80731 170690 54507 170692 375790 92949 170691 11081 51181 5236 6448 1462 2990 3373 653509 4166 3074 3073 63827 1634 26229 38 3425 2720 4958 411 6439 3423 633 1464 229 1463 10675 1594 1584 5096 4594 166785 5095 126410 5053 4860 326625 27249 56603 25974 340665 100 353 1591 4128 1439 1438 2694 2729 2730 6233 2538 7316 64087 152926 26275 549 199857 56922 3712 79868 26873 3141 51293 686 7057 7311 7314 120227 1586 1588 112812 2232 2230 1583 138050 594 10295 1629 1738 593 2937 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling 3716 3569 3976 3590 3589 867 7297 3570 6772 23529 5781 6774 5008 3572 9180 133396 1489 3717 1271 9021 9244 1270 386653 3977 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 96%9706369 Negative regulation of FLT3 7314 8835 867 9306 84174 10019 6233 7316 5795 2323 2322 6503 1445 7311 27 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME%R-HSA-9820448.2 Developmental Cell Lineages of the Exocrine Pancreas 3910 3911 3912 2252 2249 2247 3913 3914 3915 2335 2255 3918 1950 284217 10319 3908 3909 7448 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-HSA-2162123.6 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 5743 145482 873 27306 10728 5730 3248 6916 5740 1582 9536 127281 80142 8644 5742 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins 240 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death 598 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS 10071 94025 143662 118430 140453 4588 4589 283463 4582 4583 56913 394263 4584 4585 4586 200958 727897 56667 29071 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%75953 RNA Polymerase II Transcription Initiation 6872 2963 2962 6874 2068 6873 5434 6908 5435 5436 5437 5438 5439 6881 2968 6880 2967 6883 404672 6882 5430 6884 5431 8148 5432 5433 902 6875 6878 83860 6877 2959 2958 6879 2957 54457 2961 2960 138474 5440 5441 4331 1022 2071 2966 129685 2965 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111457 Release of apoptotic factors from the mitochondria 578 54205 581 1687 56616 79792 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111446 Activation of BIM and translocation to mitochondria 5599 8655 10018 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism 54898 2180 83401 9415 3992 64834 215 60481 DEFECTIVE MUT CAUSES MMAM%REACTOME%R-HSA-3359478.5 Defective MUT causes MMAM 4594 166785 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion 2770 8826 6833 3630 2182 10768 3708 3709 2181 5566 11069 10411 3745 3747 2793 2792 6514 2791 2790 2788 2787 2786 776 2785 2784 2740 2783 51764 5906 94235 6812 948 9630 55970 6513 5567 5568 6844 775 6616 6804 111 54331 112 1131 114 59345 2641 2767 5578 2864 3710 2769 5330 150 5331 4082 773 152 23236 777 5575 6861 9254 5573 2776 783 784 2782 5577 2778 3767 26251 5576 9495 10681 3790 2771 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2142789 Ubiquinol biosynthesis 57107 56997 56910 84842 79934 51004 51805 57017 23590 10229 27235 51117 84274 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 5644 8029 4548 326625 6948 1504 27249 25974 55788 2694 440387 4036 26119 6947 51293 5646 5826 4552 81693 4594 4363 166785 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome 10060 3767 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 96%1483148 Synthesis of PG 5338 114971 23646 201164 122618 5337 9489 8760 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events 808 817 818 107 5567 108 109 5568 84254 5566 111 112 5580 113 3838 114 156 115 5137 5153 5136 26960 5578 5575 10645 5573 5582 5577 814 5613 5576 196883 815 816 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 96%5674400 Constitutive Signaling by AKT1 E17K in Cancer 84335 1147 572 842 55615 4193 253260 2932 2308 79109 207 208 5170 1027 1026 7249 64223 2931 4303 2309 10000 3164 2475 6199 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9937850 NuRD complex assembly 8331 8337 8334 8335 1107 53615 8341 8342 8347 8348 8345 8340 1108 9219 8338 85236 8349 3066 7341 114825 125997 170394 8370 85509 5105 57504 8099 26038 55205 9112 6941 7329 22806 22807 3013 57592 23613 3065 10263 7182 8932 255626 9640 7026 10320 152485 84295 3021 3018 3017 3014 474382 57459 5931 8970 128312 54815 94239 55766 8968 653604 2203 54145 2538 5928 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 96%422475 Axon guidance 1297 1293 388 1292 1291 5062 25791 1287 5364 28964 8874 389 5879 160 161 2932 163 5663 5664 5781 55851 83464 23385 51107 1072 1175 998 1173 5567 5568 10093 10092 10095 10094 10097 10096 4318 5361 2886 27289 7525 4651 8503 2902 10109 6383 2534 8976 4627 22916 10552 23129 4686 6921 6923 2817 3674 3678 60 27330 375790 4628 79784 10507 6237 3984 3985 56896 22885 2676 2675 57556 5621 5623 971 148738 137970 64096 57453 10371 5786 5788 6230 116986 6231 64218 6234 779 9349 6235 56963 6191 6193 6192 10570 6194 9353 1213 23380 57522 51121 54209 1211 5362 6091 9901 8633 6227 80728 6229 9723 6228 11224 5365 200916 7305 6122 55558 6124 84448 6123 6125 1809 25873 59277 140801 220164 1826 3921 4736 55816 6130 10154 6133 8482 6132 55715 6135 4902 6134 1400 6137 9260 6136 5909 80031 6128 9048 9046 6129 1796 6142 285704 6141 3983 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 3320 2197 23521 140032 6164 6166 5306 6165 6168 5578 6201 6167 6203 6169 6202 116832 6160 6161 6175 9045 6210 6176 6171 6170 6173 51065 6205 9861 6204 6207 6233 6206 7316 6209 10213 6208 6188 5706 6187 6223 5707 6189 5708 6222 5709 6224 6181 6218 10398 5700 6217 5701 5702 5704 5705 1956 5682 5683 4756 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 5689 22794 9939 65109 2668 9775 10921 9855 55110 4116 2674 7220 7222 7224 7223 7225 387 57113 9252 3915 2041 7204 284217 2909 3912 10298 3688 8997 6453 6456 4233 219699 90249 1793 30011 6714 4893 5588 6654 3265 1969 6195 5594 5595 6464 5979 10818 53358 5604 5605 91584 3685 5747 23053 27 23708 8440 3670 6387 23032 4753 8453 4650 9423 284656 2107 2045 7410 2044 51466 4440 2043 2042 26986 1943 1605 1942 2935 1949 56924 4690 1948 1947 9355 1946 8022 7852 1945 10451 1944 6092 2051 26019 2050 55740 2049 1630 2047 8829 2046 56956 285220 5576 4313 9495 6655 10486 10487 57144 23767 5216 5217 6093 5532 7408 89884 65110 6586 2064 6585 3199 71 8851 1020 8650 24137 9475 6900 27255 11280 2048 3897 3326 10752 8828 1759 1641 5962 1808 3785 4478 3786 3680 6708 6709 55800 8986 285643 6324 9978 6323 1272 286 8861 287 288 4629 100133941 2596 51332 6711 6710 8128 4897 6712 11313 6331 6330 6332 7903 6335 10627 6334 1981 26052 214 6326 8912 8506 8913 6328 8911 6327 6329 7430 4684 103910 4637 23114 57698 57731 6336 8515 10048 1212 775 3312 9037 1785 782 783 784 785 25 8660 1742 9846 1741 1739 3672 3673 5921 6478 6477 2242 1463 6386 1600 7436 5649 776 6232 23332 23122 2887 3690 7094 5566 6197 6196 5598 85358 7074 5335 1460 1459 2904 1457 2549 4067 102 23396 23365 1286 1285 5295 256076 1284 5296 1282 5058 5290 8218 5291 5293 1299 9826 64283 1298 131873 5063 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors 5330 55970 5331 2793 23236 2792 2791 2790 2788 2787 2782 2786 54331 2785 59345 2899 2784 2783 10681 51764 94235 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases 410 412 414 415 416 22901 285362 153642 347527 79642 25870 340075 411 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME%R-HSA-9662001.3 Defective factor VIII causes hemophilia A 8460 7450 2159 2158 2157 2147 8459 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 5888 80010 5889 7486 5982 5983 3364 472 672 675 84126 144715 83990 5810 7516 5932 9156 11073 7979 641 6117 5984 5985 6119 79728 6118 5883 5884 116028 10635 83695 10111 4361 7156 5890 5892 4683 580 10524 1763 545 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 96%71240 Tryptophan catabolism 125061 6520 8564 51166 169355 8140 883 130013 23498 3620 120103 8942 56267 6999 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME%R-HSA-9617629.2 Regulation of FOXO transcriptional activity by acetylation 1387 2033 8850 7295 4303 2309 2308 10628 23410 23411 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling 2247 7049 10755 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%R-HSA-3656534.3 Loss of Function of TGFBR1 in Cancer 4087 4088 7046 7048 7040 2280 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters 6569 142680 6574 6568 6575 10568 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen 7450 2812 2815 2811 2814 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 96%3595177 Defective CHSY1 causes TPBS 633 1464 1462 1463 10675 63827 1634 22856 DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER 54107 2068 9557 142 5981 5982 5983 2968 2967 10038 404672 56655 2067 1643 8451 7507 8450 5111 1642 6117 5984 7311 5985 5424 6119 9978 7314 5425 6118 5426 5427 10714 51426 57804 6233 7316 2071 2073 2072 2966 2965 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%77387 Insulin receptor recycling 127124 23545 51382 533 3630 534 535 537 10312 50617 5770 9296 5792 245972 245973 155066 9114 51606 9550 3416 523 525 526 1509 527 3643 528 529 8992 90423 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency 6230 6231 6234 9349 6235 6191 6193 1965 8894 6192 6194 1968 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 1649 6164 440275 6166 6165 6168 6201 6167 55364 6203 6169 6202 116832 6160 6161 10985 6175 9045 6210 6176 6171 6170 6173 1386 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 467 6223 6189 6222 468 6224 6181 6218 6217 440 7311 1054 1051 57761 INTERLEUKIN-1 SIGNALING%REACTOME%R-HSA-9020702.4 Interleukin-1 signaling 3557 3553 7850 4215 841 7186 8767 4615 4791 57162 84166 10454 7334 6285 7335 3552 6288 11274 7189 64127 6283 3146 257397 51135 23118 9683 9684 10392 28512 79155 57161 79671 177 121457 246330 28511 3656 9097 11213 5604 9861 8454 6233 7316 1326 10213 6885 5706 23291 80216 92610 5707 5708 5709 1147 5700 5701 5702 5704 3554 5705 4790 5682 5683 351 4792 5684 4793 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 3654 5690 5691 5692 5693 5694 7311 5970 5695 9978 7314 6500 3551 5687 5688 8517 5689 5608 6416 8878 7157 54472 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 2549 3082 4233 5781 TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%9013957 TLR3-mediated TICAM1-dependent programmed cell death 841 8737 7098 11035 148022 8772 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME%R-HSA-9723905.2 Loss of function of TP53 in cancer due to loss of tetramerization ability 7157 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 875 4143 51540 27232 191 3176 4837 1491 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 96%114516 Disinhibition of SNARE formation 5582 6810 5579 5578 6814 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction 808 6382 5956 221914 4836 9672 9227 2239 83875 2342 338328 10988 5406 7804 2339 1208 158835 6010 2779 6295 1259 1258 4023 3339 9187 24 2792 5588 145226 2262 6121 131890 7276 336 4647 337 23173 2817 9626 50700 6011 10170 8644 3949 9249 344 2652 26020 345 3000 157506 57016 2719 151056 54884 5959 2979 8608 2978 51109 285440 2986 5950 64220 9397 5948 348 5949 388531 335 79823 6017 5947 338 5145 5578 29967 5158 5148 121214 5957 1645 1109 611 2782 53630 55937 5475 4036 3292 6383 10082 8630 6385 375790 4035 AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis 79814 113451 GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling 374 1956 4893 7039 685 6654 1950 255324 3265 2069 1839 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-HSA-446193.3 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 10402 199857 79868 140838 84920 29906 207063 6675 81849 51046 5973 440138 51005 22845 55808 6489 64841 5476 10020 256281 79644 10825 55577 2673 8813 9945 2720 197258 8818 7264 338596 8790 55343 29880 10559 84620 2762 8869 5238 116150 55907 8128 57171 282969 26503 54187 80896 54344 79947 7903 4758 129807 4759 79087 85365 29929 10195 79796 9526 56052 79053 1798 91869 5372 5373 4351 29926 29925 10610 6483 6482 6484 6487 3098 6480 4597 256435 30815 27090 144245 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 96%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA 6222 6224 6181 6218 6217 7321 84164 10973 6230 6231 6234 9349 6235 6191 6193 7311 6192 6194 7314 7322 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 90850 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 7323 6203 6169 6202 116832 6160 6161 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 7316 6206 6209 6208 6188 6187 6223 6189 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 96%400206 Regulation of lipid metabolism by PPARalpha 6822 26230 10001 25942 3158 51129 29079 10062 19 116519 336 9612 9862 183 90390 2168 948 84498 9967 1374 376497 55588 80306 96764 4899 2033 11010 6907 80205 335 8648 10891 4862 4199 51003 10499 10498 79718 6604 133522 9575 84246 8841 9611 9572 1387 9443 1579 23054 9412 5469 9441 85441 9442 406 27063 1376 9440 8202 9915 51586 2274 54600 400569 9439 55090 23097 34 57491 196 3992 50486 6837 9477 27242 7296 1543 112950 29841 81857 219541 7376 6256 5465 54797 6095 2101 5468 8800 2874 5244 1024 23389 9282 2180 2222 3157 6667 9968 9969 4800 4801 4802 9971 1581 57761 6721 4520 405 10025 211 123 6257 23179 892 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 23194 6790 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 9978 7314 80028 6500 5687 5688 5689 9861 8454 6233 7316 10213 5706 5707 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex 6604 6601 6603 6602 6605 86 55193 9274 60 9275 196528 605 55274 6595 6597 6599 6598 29117 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.3 Defective factor IX causes thrombophilia 2159 2158 2157 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins 5708 5709 5700 51529 5701 7321 5702 5704 8881 64682 5705 25906 11065 5682 8697 5683 7324 5684 10393 29945 27338 5685 119504 5686 29882 5717 891 5718 246184 5719 983 996 11047 51434 5713 51433 5347 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 890 5687 5688 5689 9184 991 8900 4085 4751 701 9861 9232 6233 7316 10213 5706 5707 DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 96%3359485 Defective CD320 causes MMATC 51293 6948 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME%R-HSA-5619078.3 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) 55343 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense 808 7314 115361 7322 2633 6233 7316 837 2634 163351 7311 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 96%5693606 DNA Double Strand Break Response 8924 8341 8342 8347 8348 8345 8340 7311 85236 8349 7314 7336 7334 11200 7341 8370 8290 51588 7329 255626 7468 29086 9025 51720 5599 472 672 84142 165918 7158 3018 3017 3014 9577 79184 3838 8970 128312 5536 8314 9656 51035 2070 7157 8467 9031 322 9682 2140 2139 10111 2138 25 4361 6233 54145 7316 4683 580 10524 23030 MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 96%1221632 Meiotic synapsis 8331 8337 8334 8335 4001 10274 8341 8342 8347 26277 8348 8243 8345 25913 8340 5885 8338 85236 8349 54386 8370 8290 7013 65057 7014 7329 3013 255626 672 3018 3017 3014 9126 3306 9985 27127 474382 10734 50511 93426 8970 10388 128312 23345 23224 256126 56158 25777 94239 6847 55766 644186 23353 8468 10735 54145 545 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 96%420597 Nectin Necl trans heterodimerization 23705 81607 5817 25945 5818 5819 57863 CARDIOGENESIS%REACTOME DATABASE ID RELEASE 96%9733709 Cardiogenesis 4086 23462 2626 4089 8320 6910 6862 9464 1482 2627 6722 4303 2648 1499 3670 4208 8861 51176 23493 9421 93649 11091 150572 57057 55897 6899 10524 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition 54107 84515 5000 5001 23594 23595 4998 891 4999 983 23649 5422 5557 5558 7027 1019 595 1017 29935 10926 898 81620 6502 91768 7465 51053 286826 9134 55388 4149 132660 1027 1026 91750 1163 5753 7029 1869 55957 5925 3065 1876 1875 1874 10000 8317 7298 28227 7083 207 26271 208 1719 9861 8454 6233 7316 5928 10213 5706 5707 5708 5709 5519 5700 5701 5702 5704 5705 5682 5683 5515 5684 5516 993 5685 5518 5686 5717 5718 5719 11047 5713 4172 5714 4173 7979 4174 5690 4175 5691 4176 5692 5693 5694 8318 7311 4171 5695 7314 6500 890 5687 5688 5689 4331 1022 8900 56655 902 990 5111 4609 6117 6119 6118 5426 5427 6241 5933 5934 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination 7978 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME%R-HSA-5619089.4 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) 9152 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance 3069 8029 335 81693 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes 25904 3276 55571 2810 5325 6790 995 891 85456 983 246175 79733 57472 1820 4869 9337 7027 890 25946 57060 1017 581 55835 898 1263 9134 1027 29883 1026 7029 1869 9125 144455 1874 8900 2033 28984 5111 1647 10498 7157 7832 23019 4850 4848 4849 10769 5933 5934 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 96%5357786 TNFR1-induced proapoptotic signaling 7132 841 8737 10616 329 29110 7186 330 331 9099 27005 220213 56957 7375 9641 55072 142678 81858 1540 9825 8717 10133 7128 7124 8772 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 96%5660526 Response to metal ions 4495 4496 4499 4489 4501 4502 4504 84560 4490 4520 4493 1465 4494 6620 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 330 10673 8742 8792 51330 7187 959 8600 4055 4050 4049 329 7186 115650 8740 9020 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 96%2473224 Antagonism of Activin by Follistatin 10272 3625 3624 10468 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 8826 55970 5567 5568 3708 3709 5566 11069 10411 111 54331 112 114 59345 2641 3745 3747 3710 2793 2792 2791 5575 2790 5573 2788 2787 2782 2786 2785 5577 2778 2784 26251 2740 5576 2783 9495 10681 51764 3790 5906 94235 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination 5591 7874 55284 3105 7321 56254 11065 7332 7324 8341 27338 8342 8347 8348 8345 92305 6596 8340 23168 9781 79577 51322 5195 7317 80349 5192 7319 5193 7311 5194 85236 3093 5828 123169 7314 51255 7322 7336 9646 997 29089 257218 55829 7334 92912 9810 118424 10477 220441 54623 8915 7327 90268 8239 7326 7328 54926 65264 79139 10670 255626 55236 3018 3017 7320 8078 56852 5111 8970 7347 7323 7415 6233 7316 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 96%9662360 Sensory processing of sound by inner hair cells of the cochlea 5756 3778 3779 5962 4478 6709 6711 129446 440699 25861 9381 161497 27445 124590 830 51168 832 11344 64072 8927 4647 9478 53904 776 494513 246213 9750 51475 259236 6855 65217 829 23136 339768 117532 117531 7430 25794 643226 286262 10518 5357 53405 10083 64787 222662 6844 83715 9132 6616 389207 6804 2059 140469 2036 5864 80331 6853 4641 9254 783 8573 490 4627 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 96%1566948 Elastic fibre formation 650 3678 3690 652 7043 4052 4053 4054 3696 4237 4238 4239 2199 8425 2192 3694 3688 8516 8076 3685 7040 5045 84171 4015 4016 4017 84695 27302 10516 84467 2202 3693 2201 30008 8200 2006 7042 2200 655 7448 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 96%448424 Interleukin-17 signaling 1147 5519 2353 4790 5515 6197 6196 55540 5516 112744 5518 8945 3725 84818 3654 8767 5528 7311 7314 6500 3551 64806 4205 10454 7334 8517 7335 64127 7189 5608 257397 5609 9261 23118 6416 5601 6195 1432 5602 10392 5606 79155 5594 5595 5598 3656 2002 466 51231 5600 1849 7867 1848 1846 1845 5604 5599 23765 4208 3605 9252 1386 8454 6233 7316 1326 27189 132014 6885 23291 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%R-HSA-110328.4 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 8331 3013 8337 8334 8335 255626 8341 3018 8342 3017 8347 26277 3014 8348 8345 25913 8340 474382 8970 128312 8338 85236 8349 94239 55766 54386 8370 8290 8930 55247 54145 23583 7013 252969 65057 4968 7014 79661 6996 4913 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559586 DNA Damage Telomere Stress Induced Senescence 8331 8337 8334 8335 4001 8341 8091 8342 8347 26277 8348 8345 25913 7290 8340 57634 3009 3008 3007 3006 3005 8338 85236 8349 3024 25842 890 1017 54386 898 9134 8370 8290 1027 23523 1026 7013 65057 5925 7014 3013 255626 8900 472 29855 3018 3017 3014 474382 8970 128312 94239 55766 7157 10111 4361 54145 4683 3159 10524 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants 3815 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 96%3238698 WNT ligand biogenesis and trafficking 54361 51384 79971 7473 7472 51699 9559 89780 7475 7474 55737 7484 7483 7477 50999 7476 7480 7479 7482 7481 8724 7478 7471 80326 64840 81029 RET SIGNALING%REACTOME DATABASE ID RELEASE 96%8853659 RET signaling 53358 2668 5567 85358 5568 2676 2675 5566 5623 64096 5335 2674 2549 5578 2886 6654 5781 5295 220164 5296 8503 5290 55816 5291 8660 5293 55715 4902 9260 2887 6464 5909 5979 5598 10818 9846 9048 9046 1796 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) 22949 4056 240 241 239 3248 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling 90865 118788 5155 5159 50852 4916 4233 4615 5879 5156 9173 6714 7189 5781 51135 5880 146850 5594 5595 2323 2322 10818 3815 3932 23533 207 5305 7409 6801 8503 3643 2534 5519 3630 2064 1956 7039 5515 5516 5518 8394 8395 5525 3654 5526 5527 5528 5529 2100 8396 2099 685 255324 2069 1839 930 3084 4915 4908 4909 9542 10718 627 145957 2549 374 1950 3082 23396 9965 2254 2252 2251 27006 5294 5295 8074 5296 2249 2248 2247 5290 2246 152831 8823 5291 8660 5293 2264 940 2255 941 942 9846 3667 8817 391 8870 26281 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes 835 94241 355 84883 332 839 10397 834 124446 10650 665 472 9540 843 604 23368 27113 8794 5875 8795 8793 5876 1121 8797 64065 63970 58484 317 8738 7157 3486 8626 7159 581 147923 51499 637 79370 55240 7161 1387 27166 55367 5366 PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 2254 5781 2251 27006 5295 8074 2249 2248 2247 5290 2246 2549 2255 10818 26281 DISEASE%REACTOME%R-HSA-1643685.19 Disease 8331 8337 8334 8335 5062 10613 100128731 192670 27161 8341 8342 8347 8348 8345 91445 6048 26523 8340 2475 91319 8338 4791 10956 85236 8349 5879 6185 23476 6184 215 57690 2932 192669 746 79109 3791 1603 81608 5781 2120 51411 27248 8370 146850 79139 2146 998 5777 471 51009 4343 6400 3013 55615 255626 84061 6772 6774 3021 3018 3017 3014 3932 7991 64223 474382 201595 10000 3703 8970 128312 3716 55766 1650 8726 8968 7518 7532 23533 7525 207 3981 208 7409 653604 7415 84661 8503 11091 23169 5133 23512 5928 5929 54658 2534 54657 1445 8178 129685 6872 22916 6874 6873 6908 4686 3718 6827 6749 3554 7297 6881 79685 6880 6883 8819 1901 6882 6773 6884 8148 3460 29760 9150 6917 3459 1025 51185 973 51497 11198 23186 6875 974 6878 3454 51742 83860 6877 10280 10284 8812 2342 2959 64426 2958 6879 25855 2339 2957 5926 25920 10362 54457 2961 51317 8189 2960 11051 51224 6921 10978 1479 6924 51692 7936 1478 6923 729238 1477 7469 138474 23283 904 10914 53981 905 51585 2697 29894 55339 6440 60 2260 6557 6559 9990 572 842 7157 9883 129401 9688 291 292 293 23225 3836 4927 6199 3159 23165 11168 55706 23636 9972 9631 7175 11097 23511 8086 22808 8021 53371 8480 10762 8815 8036 2160 23168 6230 6231 79577 6234 9349 6235 6191 80349 6439 7040 6193 6192 6194 10898 123169 1213 51121 9646 1211 6227 6229 6228 54623 11224 200916 6122 6124 6123 7301 6125 25873 2621 140801 558 197259 4360 3921 22924 4736 440400 9076 6130 6133 4061 51234 6132 10461 6135 6134 945 3309 6137 5627 6136 811 91937 11314 6128 9636 6129 6142 6141 126410 6144 6143 6146 6147 142 3304 821 6139 6138 3662 6152 6155 6154 6157 6156 6159 6158 3320 2197 23521 3837 140032 3838 3839 63982 5610 5611 6164 203859 6166 6165 6168 6201 6167 8106 6203 6169 6202 116832 57101 6160 6161 2633 402569 3840 3841 3843 5901 6175 9045 338440 6210 6176 6171 6170 6173 51065 6205 6204 6207 6206 2926 6209 6208 6188 6187 6223 6189 55107 6222 6224 6181 6218 6217 199857 79868 861 55129 50636 2194 196527 57719 121601 9785 6430 6432 6431 10250 51362 199746 6427 6426 6429 6428 10189 8683 9775 9295 10921 11338 7307 9397 9542 10718 145957 597 1080 2335 7448 8907 130340 3105 567 10053 1174 8905 1104 162 55690 1234 5902 164 4836 7322 10454 7334 7335 7189 257397 23118 5880 6279 6280 4140 1892 7534 7533 5443 5624 64135 3442 3065 3441 3815 3440 23586 80143 84282 57506 3452 3451 3449 3448 3446 3445 3444 3443 7706 6733 6732 4691 3480 1524 5878 5868 5869 6005 6521 857 6528 7410 3251 7172 3615 3614 10451 11140 6093 3183 71 7431 9475 27316 3326 79869 5045 7046 7048 1977 7170 5230 7171 1981 7249 57521 5782 84335 145173 95 57188 2591 22987 112755 143662 127833 79695 9899 10417 118430 6843 9900 10418 170689 6844 171019 6616 6857 54437 6804 3955 324 9510 9037 10568 4582 6569 5199 142680 4583 7058 4584 4585 4586 6667 200958 51128 157869 29954 727897 56667 29071 9507 9871 80070 9632 10585 140766 9508 10427 9509 10071 94025 22937 339366 221981 79875 81794 140453 55901 4588 31 4589 81792 55624 283463 9719 56999 10802 56913 11093 394263 10484 11173 11096 11095 11174 9215 80731 170690 54507 170692 92949 170691 8772 92421 3002 27243 3553 128866 834 10015 837 83737 79643 841 51652 8737 11035 653509 3606 7186 79792 29082 91782 3552 25978 1687 3146 8717 6584 5096 4594 166785 5095 2147 326625 27249 25974 57599 476 477 478 53822 3710 53826 1591 10060 53828 480 481 482 483 486 2694 5348 5349 3767 7535 815 816 817 64087 818 152926 26275 549 56922 3712 139285 10768 3708 3709 5566 3141 8460 2677 2159 7295 2158 51293 8459 686 4193 5609 6416 5601 1994 120227 1029 3569 710 930 3456 5599 1051 1191 722 4915 725 4908 10817 4909 5335 627 2549 374 1950 598 1938 1937 1915 9148 28514 182 54492 57534 102 54567 6868 3714 50628 6632 6628 79760 54960 6634 6633 6636 6635 6637 25929 79833 6607 8487 11218 440689 6833 721 718 6476 8678 23479 81631 7405 56606 3938 2984 4843 23443 340024 10965 6505 54716 6507 9056 153201 6520 5824 10421 55588 91662 22863 11254 27072 285755 11136 80306 57794 6519 317649 22826 22827 11282 1052 7841 4318 29801 6993 25921 11100 253832 51201 23339 10262 55741 54883 11320 51125 90701 4247 11325 10236 51304 4249 55749 10610 64225 4131 6483 8974 6482 6484 23765 23524 6487 4245 54431 4124 10450 57703 6480 684 25834 689 23193 11311 256435 10465 79844 5479 2530 27090 54463 53938 11253 5589 28972 5033 51114 64601 24148 9868 23020 85313 9879 9410 9412 814 9416 10181 9685 79651 51340 23478 10769 5093 9332 5094 3586 51593 4627 57461 84844 65082 1982 1993 27238 400569 8175 283208 51726 51729 2308 55090 7097 7096 2634 23097 80273 112744 51503 23601 55696 10992 10525 10527 5725 10523 6837 4670 3654 84818 4666 10951 3107 3106 988 10134 6627 6629 2100 220988 3134 3133 9908 81857 23450 23451 56949 5546 55733 6638 10146 219541 3135 10594 6421 25820 550 115361 54797 10332 10333 6441 5356 3178 80824 79849 3181 3188 3187 3674 3185 3184 3676 55666 9716 5119 10313 3191 3190 7555 57617 51639 10628 4057 8896 1024 163351 51645 6238 8672 23389 85437 9532 7353 10084 10291 9789 10294 4303 23367 8449 11151 55823 11123 2923 10283 8241 25777 23350 10286 10285 9343 56259 26276 9111 23327 10945 10946 10949 10907 9360 60559 10013 1654 27339 1665 10014 4939 84991 3605 2521 83443 10025 892 3276 10001 3280 25942 29079 3066 1594 1584 9612 9862 114609 948 6271 84441 8312 54815 84246 51564 23493 9443 2729 9441 9442 2730 9440 51586 23462 9439 10155 1956 7039 2811 2810 9219 9477 7296 7057 112950 7291 1514 7750 1586 3726 2874 9282 2645 138050 222236 2648 833 3516 1107 79885 4853 4854 4855 1108 83933 4869 5728 10971 5978 22938 57459 51003 2261 84447 55869 6886 5956 2064 8850 3164 2328 4158 5371 9734 9968 9969 29959 25 4087 4088 4089 53615 9794 10046 64840 246213 80304 90390 5053 4904 3845 8085 2538 4296 8315 5245 3717 2244 2266 9530 7414 8844 10256 54518 8826 22866 3818 7450 3690 2161 5894 5037 26873 2243 7094 5908 369 283455 408 409 4891 30061 51606 9843 1356 29110 3661 81030 10479 285195 594 10295 1629 1738 593 3587 5155 81693 5034 8029 19 160 161 163 1175 1173 3069 5567 5568 3417 9061 9060 2548 4969 2542 2683 3098 4060 2799 22856 11041 11285 2331 378884 6383 10082 6385 2584 2582 130589 6382 2804 2592 2588 3795 221914 9672 440138 2239 5507 22934 2132 2131 176 3339 8908 1639 1836 4669 2023 2262 5091 26503 26154 2817 8647 9197 9469 368 116085 5826 8671 6530 123041 10999 6524 10599 7355 5172 7957 55630 92579 1811 6513 10058 6566 2719 5549 9152 682 6575 5244 126792 55788 28234 81031 55315 283652 6888 6578 113189 26007 2998 2997 2632 2992 375790 11081 51181 2646 5236 6448 4166 26229 4958 229 929 7187 9641 148022 2305 5551 29851 51530 2323 57504 3192 9112 5959 4860 56603 340665 100 353 64241 64240 2589 54956 143 2931 56965 83666 79668 84875 54625 5593 4128 3092 1439 57448 1438 5495 5573 53335 238 27436 6801 9451 55247 4968 79661 4913 9525 51160 55048 89853 11267 51028 155382 137492 27183 93343 7251 51271 79720 84313 51510 51534 7284 1583 1452 611 30835 391 7879 6916 3688 63916 1794 1793 24 23191 55914 79087 85365 29929 5499 10195 79796 9526 56052 79053 1798 91869 5500 1589 5373 1585 4351 5747 21 4650 26986 1605 4690 7852 8829 5576 22845 5476 10020 79644 2673 8813 8818 55343 10559 116150 54344 79947 4758 7113 59272 26762 685 255324 2069 2002 1839 8878 375 3312 4143 4552 191 1312 4548 399687 11052 9965 26127 5289 1523 2254 2252 2251 27006 8074 2249 2248 2247 2246 152831 8823 8660 30849 2264 2255 54106 9846 3667 8817 26281 1244 3570 118788 5159 50852 4916 7318 7317 10533 7276 3799 55236 57674 89122 23352 9246 4008 9817 9039 8065 79876 51191 7428 8496 3082 10207 92359 64398 2937 1488 1487 10811 1535 10458 55845 10787 8936 10152 124056 613 4170 3071 10163 27035 10006 23649 5422 50616 1789 1788 1786 5557 5558 708 5156 6523 6514 6531 5663 5664 388585 55851 83464 23385 51107 26508 5002 9844 3055 926 2652 11045 4072 10093 10092 10095 4210 10094 5025 10097 10096 1855 57105 111 10810 112 113 114 115 2268 1857 1856 7454 7456 2678 5027 64174 147179 10910 1511 136 4907 2687 4620 2209 346562 5575 4641 1800 10800 2214 2212 4651 29108 644150 114548 26999 953 5577 5336 4644 5613 957 719 10109 8976 196883 6850 2771 2770 695 10552 2781 9051 2773 107 108 109 51517 5987 8658 80351 3978 928 3084 9420 1593 6948 1852 1850 11221 8767 4615 9187 64127 51135 7100 10392 81793 3656 1849 1848 1185 27044 23164 8805 8546 57670 10827 10142 54845 56829 9444 57085 5950 9715 11044 55109 4000 22906 8087 55750 80853 5947 203068 9861 8454 6233 7316 10213 6885 5706 5707 11116 5708 5709 1147 5700 5701 5702 5704 5705 4790 5682 5683 4792 5684 4793 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5970 5695 7314 6500 3551 5687 5688 8517 5689 145226 7341 55763 2099 8729 2908 9759 7329 9321 7486 5982 5983 3364 472 672 675 84126 144715 83990 64220 5810 7516 5932 9156 11073 641 6117 5984 5985 6119 79728 6118 5883 5884 116028 10635 83695 10111 4361 7156 5890 5892 4683 580 10524 1763 545 5888 80010 5889 51529 7321 8881 64682 9382 25906 11065 8697 7324 10393 29945 27338 119504 29882 891 246184 996 51434 51433 9146 6456 4233 8027 6455 2060 79872 1500 1499 30011 999 6457 867 10254 6714 2803 4893 6654 3265 9648 673 1432 1398 5594 5595 6464 10818 5906 7529 5604 5605 162417 445 435 1373 10166 5009 57407 383 2033 3043 23643 3162 3040 6907 335 6017 2812 2815 2814 7514 79718 54464 7099 4780 8841 9611 50507 2885 6777 6776 1387 5292 1545 5469 113612 23028 2288 2280 1655 808 5478 23189 84290 5052 7001 4001 7531 8851 1020 10728 351 2801 10018 993 994 356 9227 995 831 823 824 826 6648 2309 3725 4478 60482 4851 9978 2793 2792 2791 2790 6711 2788 2787 2786 2785 2784 2783 6469 51764 94235 55970 50846 2263 54331 59345 7855 8322 89780 7474 8325 8323 8324 2782 3549 2778 10681 8452 4763 399473 161742 200734 1462 2990 3373 3074 3073 63827 1634 38 3425 2720 411 3423 633 1464 1463 10675 7027 1021 1019 595 1017 894 896 1871 898 1870 51343 6502 2237 1616 9134 1028 1027 1026 1974 1973 546 7029 1869 5925 2322 6232 8655 27121 79412 83999 348995 27123 57122 54894 317772 51143 92815 6249 55746 85235 8969 221613 81622 23279 7098 79023 51284 51311 4040 22943 4153 6396 4041 1781 712 1780 1778 716 5648 57551 5905 7520 1660 1783 5501 2547 115004 5903 5519 340061 3831 3665 9208 140735 5515 5516 5518 2153 22872 79902 5525 5526 5527 5528 5529 5395 4436 4437 4292 2956 2157 551 552 553 10342 554 7082 5440 5441 8732 4331 8731 1022 2071 6829 2966 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 1588 404672 5430 5431 5432 5433 902 112812 2232 2230 1460 1459 1457 4609 5931 917 4067 94239 9070 920 11160 4751 253260 142678 5294 5295 5296 5290 5170 5291 5293 54145 58505 940 941 942 6934 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960519 CASP4-mediated substrate cleavage 3553 836 3606 837 79792 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME%R-HSA-8853884.3 Transcriptional Regulation by VENTX 1029 3569 51529 7321 8881 64682 4790 25906 11065 8697 7324 192670 1051 10393 29945 27338 119504 29882 79813 246184 996 26523 51434 51433 27327 5970 1499 7157 23112 57690 595 10919 192669 51176 1436 51343 27287 6934 4343 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 96%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) 7108 3930 1595 1718 6307 50814 1717 6309 10682 51478 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%71064 Lysine catabolism 501 10157 51166 51268 55526 2639 85007 1738 1428 89874 123688 1743 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 96%9769739 Regulation of clotting cascade 6382 7450 3818 5657 2161 2155 2152 351 221914 2811 9672 5197 7056 2153 2160 2239 5270 2159 5104 2158 10544 6609 5196 196527 8858 57126 462 3339 2157 2262 51156 2817 5627 3053 5624 710 2149 2719 2147 2812 203859 3827 2815 2814 5054 11093 6383 10082 6385 375790 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9656256 Defective OGG1 Substrate Processing 4968 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME DATABASE ID RELEASE 96%9634815 Transcriptional Regulation by NPAS4 30818 9915 3630 2353 8851 1020 192670 27161 627 6722 26523 146713 27327 341359 7514 440073 23112 4193 10135 57690 266743 192669 1387 405 2669 5594 406 5595 2908 5978 10769 5979 4343 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication 6742 7156 56652 246243 11232 5428 5442 92667 9941 COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation 3691 91522 1297 1296 1295 1294 3655 1293 283208 1292 1291 1290 1305 1303 1302 1301 1289 1300 5339 1288 1287 85301 1308 1307 84570 1306 5034 4316 1514 10491 23127 10536 871 5351 5352 8985 55214 1515 64175 26577 5118 79709 4314 4318 1278 1277 4322 7837 8974 140766 9508 9509 84171 4015 4016 1520 4017 84695 7093 1508 5479 7092 649 50509 5033 1286 1285 256076 1284 1282 1281 169044 1280 81578 80781 3914 9313 255631 1299 1310 3918 57642 977 1298 340267 7373 131873 3909 136227 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 96%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 1137 1136 1146 1145 1144 1143 1141 MET ACTIVATES RAP1 AND RAC1%REACTOME%R-HSA-8875555.2 MET activates RAP1 and RAC1 1399 1398 5879 85440 2549 3082 5908 4233 5906 2889 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%5661270 Formation of xylulose-5-phosphate 9942 51181 6652 51084 10327 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 96%8935964 RUNX1 regulates expression of components of tight junctions 7082 861 865 7122 100506658 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 96%8878166 Transcriptional regulation by RUNX2 650 4086 4089 23314 3280 4091 891 4094 983 10273 1019 6714 595 2932 581 8493 6502 10432 1026 5594 9358 5595 5925 221044 117581 6772 6662 2737 2736 10000 59269 10891 57154 11059 133522 121340 7525 8841 207 208 23493 25937 9861 8454 6233 7316 10213 5706 5707 5708 5709 23462 5700 5701 5702 5704 5705 5682 861 5683 865 5684 5685 5686 9464 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 4488 7311 7291 5695 9978 7314 6500 5687 5688 5689 1749 1750 2099 367 2908 9759 2101 3958 3678 579 25925 1277 4322 10413 632 10013 3549 25 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 96%74713 IRS activation 3630 8660 2887 3643 3667 REGULATION OF NF-KAPPA B SIGNALING%REACTOME DATABASE ID RELEASE 96%9758274 Regulation of NF-kappa B signaling 7314 1147 7157 3551 84166 8517 11274 7189 9683 9684 841 79671 6233 121457 7316 7186 9097 7311 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-HSA-446353.3 Cell-extracellular matrix interactions 7408 2318 6251 7016 29780 54751 55742 3688 3611 87 55679 3987 10979 2316 9459 5829 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 96%379397 Enzymatic degradation of dopamine by COMT 220074 4128 1312 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC 51807 10381 10383 10382 112714 7846 84790 84617 347733 7277 22948 7278 81027 908 79861 113457 6950 7203 7280 10693 10574 10376 10694 10576 10575 80086 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 96%3371378 Regulation by c-FLIP 841 356 355 8737 8795 7186 8743 8797 8717 8772 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190371 FGFR3b ligand binding and activation 2246 2254 8817 26281 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 96%9705462 Inactivation of CSF3 (G-CSF) signaling 8065 7321 7297 6772 6774 1441 8651 9616 7311 7323 3716 4067 6921 7314 7322 6923 6777 6776 3055 6233 7316 3717 9021 6850 1440 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway 4012 3134 3105 3133 1520 567 1515 3107 1514 3106 3135 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis 1723 7372 790 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%8874177 ATF6B (ATF6-beta) activates chaperones 8720 51360 3309 1388 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 96%75892 Platelet Adhesion to exposed collagen 4067 3672 3673 8515 7450 2811 11093 3688 2812 2207 2534 51206 2815 2814 REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 96%9861718 Regulation of pyruvate metabolism 79018 54994 10296 10048 1737 4289 25852 80232 54704 2954 7311 4199 7314 1738 5162 5163 5164 5165 5166 64795 23409 4750 64777 6233 8050 7316 5160 5161 57546 55066 3939 INTERLEUKIN-1 PROCESSING%REACTOME%R-HSA-448706.3 Interleukin-1 processing 5970 1511 3553 834 3606 3552 4790 4791 79792 KINESINS%REACTOME DATABASE ID RELEASE 96%983189 Kinesins 10112 1062 9493 3831 3832 3835 56992 24137 89953 11004 29127 11127 9371 285643 9585 55083 23046 55605 113220 3833 3834 90990 23095 10749 22920 55614 146909 55582 81930 23303 124602 3797 84643 3796 64147 221458 547 64837 26153 3798 147700 3799 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME%R-HSA-168330.5 Viral RNP Complexes in the Host Cell Nucleus 3304 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351202 Metabolism of polyamines 5708 5709 5700 262 5701 5702 5704 5705 5682 51686 5683 5684 113451 5685 51582 5686 5717 6723 5718 5719 6611 79814 11047 5713 5714 7979 5690 5691 5692 5693 5694 5695 6303 5687 5688 5689 1728 4947 4946 4953 9861 10213 196743 5706 5707 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME%R-HSA-5619104.4 Defective SLC12A1 causes Bartter syndrome 1 (BS1) 6557 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%446203 Asparagine N-linked glycosylation 8774 8775 1294 22796 9382 84920 100128731 10652 3998 25839 22818 26286 91445 6048 22820 83548 63908 57511 10466 10956 6185 84342 6184 4122 91949 746 1603 432 433 55768 6811 11316 79139 51009 11070 6400 79087 85365 29929 10195 79796 84061 9526 56052 79053 1798 91869 11282 7841 11014 5372 5373 4351 29926 7991 29925 55741 11320 201595 4247 3703 4249 10610 9486 6483 1081 6482 6484 2683 6487 3098 4245 9276 84447 4124 51035 1650 6480 84364 25834 1315 23193 256435 1314 30815 2530 27090 11253 5589 7415 144245 124872 10402 2804 3630 26958 140838 29906 207063 51014 6675 81849 2801 23423 51046 5973 57134 440138 51005 4121 51272 22845 10905 55808 4253 6489 64841 5476 10020 79694 256281 79644 10825 55577 2673 8813 6708 9945 197258 6709 8818 7264 64377 338596 8790 55343 29880 286 1639 10559 287 9695 84620 288 2762 8869 5238 51332 116150 9334 55907 6711 9331 9761 6710 8128 57171 372 6712 282969 26503 54187 381 80896 54344 9527 79947 7903 7369 4758 11015 129807 4759 64772 54732 51226 57731 375 8703 8704 8702 2517 1522 51128 2923 9871 9632 10427 4597 4905 10945 10802 10484 1604 55860 51164 2890 10671 93661 84516 2525 5887 3972 2720 830 832 829 811 8655 375056 821 4248 51143 1453 6396 1781 1780 1778 6233 7316 10540 1783 5700 199857 79868 7039 378 140735 79090 5265 6399 5861 23243 22870 2153 22872 2348 10175 377 5537 10972 9554 9117 80267 11196 10299 64689 10206 126003 56886 267 55291 23256 7844 10121 1075 55757 7311 11236 58485 254263 25956 7314 55014 81562 51693 2157 122553 8615 966 10342 27095 149111 9919 81876 83696 10959 10113 90411 10282 26984 9570 51399 89866 8729 79748 7109 128637 10960 374 55738 11258 58505 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling 3716 3569 3572 867 7297 3570 3717 6772 5781 6774 9021 SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL 4087 5045 4088 5046 4089 8928 10589 4838 10637 7044 55997 130399 91 6997 93 6998 199699 9350 5594 5595 2657 2309 92 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation 8331 3013 8337 8334 8335 255626 8341 3021 3018 8342 3017 8347 3014 8348 8345 8340 474382 8970 128312 8338 1789 85236 1788 8349 94239 1786 55766 8968 653604 8370 54145 29128 29947 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111461 Cytochrome c-mediated apoptotic response 331 317 842 22900 57099 55075 840 56616 51074 836 54205 5594 5595 REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 96%877312 Regulation of IFNG signaling 3716 5770 3458 8554 3717 7341 5781 5777 3460 9021 8651 3459 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) 6507 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 96%5654221 Phospholipase C-mediated cascade; FGFR2 2254 2252 2251 27006 8074 2249 2248 2247 2246 5335 8823 2255 8817 26281 CHD1 AND CHD2 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943411 CHD1 and CHD2 subfamily 8331 8337 8334 8175 6925 8335 6749 4654 4656 8341 8342 8347 8348 11198 8345 10992 6929 8340 10523 23168 79577 80349 8338 85236 6627 8349 6629 123169 9646 23450 23451 6938 54623 6638 8370 3013 255626 51639 3021 3018 3017 22827 3014 10291 10262 474382 11325 8970 128312 94239 23350 55766 10285 1106 8968 10946 6632 6628 653604 1665 84991 9879 6634 6633 83443 6636 6635 54145 1105 6637 84844 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling 9542 2064 2886 3084 DNA DAMAGE REVERSAL%REACTOME%R-HSA-73942.4 DNA Damage Reversal 54890 221120 51008 84164 10973 121642 4255 79068 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME%R-HSA-389977.4 Post-chaperonin tubulin folding pathway 347733 6903 7277 51807 7278 10381 10383 81027 10382 79861 113457 112714 7280 402 6905 7846 84790 10376 84617 6902 80086 1155 6904 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 96%5686938 Regulation of TLR by endogenous ligand 948 6271 51284 7099 929 2243 7097 7096 1687 3146 6279 23643 6280 10333 3929 2244 338 2266 79792 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells 4353 4025 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 96%1592389 Activation of Matrix Metalloproteinases 7077 7076 5644 5340 4317 3818 4312 4319 4324 4326 7177 1504 50859 440387 4318 1215 4322 3817 64386 1511 5045 1991 10893 4316 1513 80781 1515 5645 4313 4323 4320 4314 4325 INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion 55107 5045 121601 57101 338440 55129 50636 7113 63982 59272 196527 57719 203859 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654710 PI-3K cascade:FGFR3 2254 5781 5295 8074 2249 2247 5290 2246 8823 2549 10818 8817 26281 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 96%110312 Translesion synthesis by REV1 6119 7314 6118 5981 5982 5983 5980 10459 51455 5111 6233 7316 6117 5984 7311 5985 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) 551 554 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade 808 3000 2979 2978 4836 2986 9397 2342 10988 388531 79823 2339 5145 5578 6010 2779 6295 5158 1259 5148 1258 9187 5957 2792 5588 131890 2782 23173 5475 9626 6011 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%180689 APOBEC3G mediated resistance to HIV-1 infection 5478 8815 3159 11168 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 96%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 3417 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 96%111459 Activation of caspases through apoptosome-mediated cleavage 331 317 842 836 54205 840 EGFR DOWNREGULATION%REACTOME%R-HSA-182971.8 EGFR downregulation 5782 1956 7039 8874 374 9146 10253 6456 1950 8027 6455 29924 2060 7311 7314 30011 6457 867 10254 10252 58513 5774 5796 6233 7316 685 998 255324 2069 1839 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 96%8985586 SLIT2:ROBO1 increases RHOA activity 9353 6091 4650 387 VLDL CLEARANCE%REACTOME%R-HSA-8964046.2 VLDL clearance 7436 346 51599 55911 338 341 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE 57580 10276 9138 11214 128272 7531 26230 121512 29 5924 84904 100271715 10018 25791 89846 54848 26084 22899 50649 8874 8997 64857 6453 7984 57449 389337 445328 2245 221472 55701 9500 27018 10672 23263 9459 7311 5879 7314 4168 7189 6654 5663 27237 5664 55851 83464 23385 51107 836 4803 4804 835 8878 5599 7074 23421 26574 572 55160 7410 23365 23370 9181 7409 1894 10451 6233 7316 9826 7204 9828 6655 23229 50650 9639 COMPLEX I BIOGENESIS%REACTOME%R-HSA-6799198.5 Complex I biogenesis 54539 91942 90871 29078 137682 4722 4705 4707 4708 4709 4700 4701 4702 4704 4698 4716 4717 4718 4719 51079 4710 4711 5018 4712 4713 4715 51295 3313 28976 4728 4729 4720 4723 4725 4726 25915 55572 4731 100996939 55101 150274 51300 374291 55471 4706 119559 4540 4541 4535 4536 4537 4538 84233 25880 80224 51103 284184 4714 4694 4695 4696 79133 57226 126328 55967 55744 55863 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 96%9927020 Heme assimilation 3043 3040 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) 3373 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family 143662 118430 4582 4583 4584 4585 4586 200958 727897 56667 4067 10071 94025 140453 26253 4588 4589 50856 170482 283463 10462 93978 338339 394263 5336 2207 2534 6850 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME%R-HSA-5205685.9 PINK1-PRKN Mediated Mitophagy 8878 65018 54543 9804 7332 5071 81631 55669 9927 10452 29110 7417 100188893 7416 7311 7323 401505 51001 7419 56993 7314 7322 7334 7335 10133 9868 9140 9474 6233 7316 84557 79065 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%73762 RNA Polymerase I Transcription Initiation 2068 3065 5434 6908 5435 5437 1107 2968 2967 404672 53615 902 8850 1108 2074 57459 5931 9219 54700 221830 7343 25885 54815 9014 2648 9015 9013 64425 7270 79101 10849 30834 84172 3066 10919 51082 9533 5440 5441 4331 5928 1022 57504 2071 2966 9112 2965 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation 23462 121340 23314 6714 632 7525 8841 865 10013 25925 3280 23493 4094 25937 25 1277 5594 2737 5595 367 5925 10413 221044 PRIMITIVE STREAK FORMATION%REACTOME%R-HSA-9754189.5 Primitive streak formation 1499 4087 4088 4089 387332 8928 652 51176 8320 51592 6862 145258 83881 6657 5460 79923 6932 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease 5290 5335 2549 2264 4893 6654 10818 3265 5295 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins 28988 2911 81858 2915 22871 23136 9066 57502 6812 9546 22839 57669 58512 10611 91683 127833 57555 85358 9454 9455 347731 347730 6857 6804 9456 55327 22829 22941 50944 26037 26045 2904 57596 2037 2035 9229 2036 9369 54413 341359 9378 9379 321 80059 8825 1740 143425 2906 8573 2905 2903 2902 320 1742 1741 64130 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 96%420029 Tight junction interactions 84612 5010 10686 7122 9069 137075 24146 9073 5584 9071 9074 9075 84552 9080 53842 50848 10207 1366 92359 64398 1365 1364 56288 50855 51208 9076 49861 23562 149461 26285 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME DATABASE ID RELEASE 96%450531 Regulation of mRNA stability by proteins that bind AU-rich elements 5708 5709 5700 5701 5702 8021 5704 5705 5682 5683 5684 5393 11340 5685 22894 23016 5686 8570 5717 23404 5718 5073 5719 51010 54512 11047 51013 5713 56915 5714 118460 7979 5690 5691 5692 5693 5694 7311 5695 7314 5687 5688 5689 9261 1432 7538 1981 1994 8125 8741 7534 6418 677 5600 3842 7529 3304 3312 5580 3315 5578 7514 54464 167227 55802 207 26986 9861 6233 7316 10213 5706 5707 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 96%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 572 27113 90427 596 598 6774 10018 637 5366 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME%R-HSA-9723907.3 Loss of Function of TP53 in Cancer 7157 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9026357 NTF4 activates NTRK2 (TRKB) signaling 4909 4915 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 4067 2057 5290 2056 5291 8660 5293 2549 23533 3717 5294 5295 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis 695 10552 10787 8936 71 51517 10152 3071 10163 63916 10006 1793 5879 23191 1398 9844 3055 5594 5595 998 10093 10092 10095 10094 10097 10096 60 10810 2268 7454 7456 5747 917 4067 147179 4620 4650 7410 4641 7525 2214 7409 4651 4690 644150 26999 10451 25 4644 10458 10109 2534 8976 55845 4627 6850 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 96%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) 55253 55039 57570 9836 127253 129450 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS 1399 4067 2057 2056 8660 4893 6464 6654 3717 3265 2889 7409 DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 8029 81693 2694 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 96%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) 6575 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 5423 328 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation 808 817 818 5519 7529 5604 5894 5605 22808 8036 369 5515 5516 5518 5500 5525 5526 5527 5528 5529 6714 4893 3265 673 4140 4296 8315 5245 3717 815 5501 8844 816 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764260 Regulation of Expression and Function of Type II Classical Cadherins 28513 192670 27161 6663 26523 6667 9839 51129 27327 1500 1499 23112 57690 192669 26508 2294 56978 3728 8728 64403 1495 27319 80332 1006 3224 80149 3609 6615 4343 1009 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME%R-HSA-9652282.4 Drug-mediated inhibition of ERBB2 signaling 3320 55914 2064 11140 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 96%111463 SMAC (DIABLO) binds to IAPs 331 317 842 836 54205 840 56616 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020956 Interleukin-27 signaling 3716 3572 9466 821 246778 7297 3717 6772 6774 10148 9244 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 96%5083636 Defective GALNT12 causes CRCS1 10071 94025 143662 79695 118430 140453 4588 4589 283463 4582 4583 394263 4584 4585 4586 200958 727897 56667 DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions 3824 695 100132285 567 9436 23601 3809 5335 3932 100049587 3810 3813 10326 3822 22914 3107 3106 5879 54209 3133 9402 4893 7410 6654 7305 3265 5295 5296 5290 10451 5291 5336 3937 124599 2534 342510 54210 6850 284266 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding 126123 49 100129669 113177 928 284359 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 96%480985 Synthesis of dolichyl-phosphate-glucose 29880 256281 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8866423 VLDL assembly 5034 346 4547 338 341 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders 5708 5709 6833 5700 5701 5702 5704 5705 10613 5682 5683 5684 5685 5686 5717 5718 91445 5719 6048 11047 5713 5714 7979 5690 5691 91319 5692 5693 5694 10956 7311 5695 7314 19 5687 5688 215 5689 27248 26154 8647 79139 368 5826 51009 6400 10058 5244 55788 64241 64240 335 21 10060 11160 7415 9861 6233 1080 7316 3767 10213 5706 5707 1244 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170968 Frs2-mediated activation 1399 7529 5604 4803 5605 5594 5595 10818 5906 2889 673 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8941855 RUNX3 regulates CDKN1A transcription 864 4088 7157 1026 4089 463 7040 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 993 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 9978 7314 6500 5687 5688 2932 5689 11200 1432 1263 5600 1454 1452 79858 1111 9861 8454 6233 7316 10213 5706 23291 5707 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013148 CDC42 GTPase cycle 9341 394 23092 10395 57580 143872 396 26030 55619 397 398 128239 85360 5062 7879 128272 5337 29 121512 10298 5924 10652 64411 29127 25791 89846 613 81839 10788 26084 22899 26286 50649 28964 8874 64857 85440 6453 7984 116984 55114 2245 221472 10672 23263 9459 4983 23380 3895 57522 55789 9901 7112 80728 4168 27237 115703 81624 139818 201176 11135 57514 55240 124997 58504 1123 114793 998 57569 92799 57572 10602 752 51133 64333 116985 9912 101059918 23526 29062 79658 51291 56990 10435 83478 7454 7456 9644 23268 51306 147179 9411 393 857 84364 4650 148170 23348 7410 89839 23580 10160 25894 56924 644150 10928 10451 4296 8976 57480 57144 117289 8826 343578 50619 221178 257106 153478 80243 55004 3930 7074 7037 23002 23365 115557 23048 91010 50855 54874 5295 5296 1894 5058 144402 8773 8476 9754 81704 2040 3728 9578 23513 10458 9826 7204 90627 9743 9815 2909 23229 57584 9639 5063 392 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer 23439 4087 4088 4089 7321 64750 51592 1025 4092 8812 7311 7314 7050 5045 7027 904 905 8239 9612 5594 7029 5595 5494 1030 60436 22938 3065 142 3726 4904 1875 1874 1024 2033 1278 6667 4609 7323 5054 23327 4221 9611 25937 6233 6498 7316 6497 5933 892 54778 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%194002 Glucocorticoid biosynthesis 1584 5443 1586 1589 1585 3284 3283 3291 3290 866 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription 2735 2737 2736 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 96%170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 23636 9972 5903 9631 7175 11097 2646 23511 8086 8021 53371 8480 10762 348995 79902 57122 2645 55746 23279 79023 6396 9883 129401 9688 23225 4927 23165 55706 DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination 8331 8337 100287327 440689 55593 8334 7321 8335 10617 8313 93624 8678 10868 90865 8341 57559 10869 8342 8347 8348 8345 983 83844 8340 79589 9146 10600 8027 8338 23326 79931 85236 8349 9099 100287178 5728 10254 10454 7189 8724 100287144 3416 23770 6314 91833 100287364 154 3013 64135 5423 23586 255626 84282 57506 3018 2033 3017 7706 100287513 114785 55288 3054 55252 401447 55777 3607 7345 8970 7347 128312 221937 123228 8314 171023 23032 100287238 100287478 221656 9868 7415 728386 114548 57646 100287205 100287441 100288520 100287404 55031 57695 25862 6881 54764 55611 8975 81847 23252 9100 993 8658 80351 8850 219333 78990 64426 84196 9960 10318 55432 7046 7048 23172 51651 84101 9986 377630 392188 7528 23358 84132 80124 645836 29761 645402 324 60 10474 4287 7353 8078 728419 4303 114803 27430 7157 4086 8607 4087 125476 4088 7874 93973 4089 29844 54891 79913 54617 5071 283899 64750 83444 5886 5887 6478 4092 4798 8737 329 10445 7186 8473 126119 8767 92552 7040 9929 330 27005 56957 7375 11274 7187 64127 8239 1540 86 7128 6502 10392 79155 9097 63891 991 29086 51720 63967 84142 9577 1643 9958 79184 9736 51377 8312 9101 57599 317772 92815 85235 8969 221613 8295 89122 79594 9738 9861 6233 7316 10213 6885 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 4792 408 5684 409 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 7417 5692 5693 7416 5694 7311 4194 7419 5695 7314 890 5687 4193 5688 8517 5689 4738 2099 367 9817 2625 9804 8900 672 4609 3091 2648 387 1080 84749 580 161725 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events 808 2770 817 818 2774 2773 107 108 10768 109 3708 84254 3709 5566 5332 5594 9630 5567 5568 111 112 5580 113 3838 114 5321 156 115 5137 5153 5136 26960 2767 5578 3710 2769 5330 5331 23236 346562 5575 10645 5573 2776 5582 5577 814 5613 5576 196883 815 2771 816 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953078 MPS II - Hunter syndrome (CS DS degradation) 3423 FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 96%9830364 Formation of the nephric duct 130497 1499 57526 652 3214 3975 5076 10406 255743 2018 2122 2247 3203 3400 51316 7849 5979 2625 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4551638 SUMOylation of chromatin organization proteins 23636 5903 9972 9631 7175 11097 23511 1107 8086 8021 23314 53371 8480 10762 8535 79902 9189 648 6015 6304 83746 1912 1911 3066 7341 80012 84733 8370 8554 6045 6612 9759 7329 6613 3065 57332 348995 57122 7703 55746 23279 79023 6396 9883 129401 9688 23512 23225 4927 23165 23468 55706 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 96%5223345 Miscellaneous transport and binding events 84230 348938 55144 56262 123606 84061 79815 118 80131 2039 57380 5304 56172 152519 54896 7991 120 563 6005 57127 1497 51458 23507 57185 119 93380 81614 AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9612973 Autophagy 92421 65018 27243 128866 7332 8678 5071 79643 81631 7405 55669 51652 9927 53632 2475 10533 7322 29082 7334 91782 7335 25978 11345 8408 2034 10133 11337 8655 5562 5563 22863 5564 5565 3320 3043 10226 5571 64223 51143 51001 1781 9868 1780 7415 8897 1778 3297 6233 7316 1783 51160 55048 89853 155382 137492 93343 7251 51271 79720 140735 3326 64419 7417 7416 7311 7419 7314 55062 7248 55004 8649 64121 7249 58528 10542 389541 8100 28956 115201 57521 55054 10670 89849 6009 285973 56270 153129 55626 9776 23710 8878 84971 10325 440738 9821 60673 54543 11152 84938 9804 83734 64422 23192 472 26100 3312 5116 1460 10452 1459 29110 1457 100188893 7323 401505 1915 56993 5289 51422 10013 9140 9474 1080 200894 30849 84749 84557 6035 2670 139341 123 4077 1068 5830 3920 79065 11315 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 96%5654743 Signaling by FGFR4 5515 5516 5518 10817 5335 2549 10253 8569 7311 7314 867 9965 4893 6654 2254 3265 5781 2251 8074 673 5295 2249 2247 2246 5290 152831 8823 6233 5594 7316 5595 2264 10818 8817 26281 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357769 Caspase activation via extrinsic apoptotic signalling pathway 355 8743 841 356 8737 23643 8795 7186 1613 1612 23604 8797 219699 9500 90249 26060 842 7099 929 353376 148022 8717 836 1630 8772 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) 2720 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428643 Organic anion transport by SLC5 17 25 transporters 1468 8402 6576 160728 159963 26503 GSD II%REACTOME%R-HSA-5357609.5 GSD II 2548 2992 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 5708 468 5709 5700 5701 5702 5052 5704 5705 4790 5682 5683 5684 5685 5686 5717 5718 5719 8945 7295 11047 5713 5714 7979 5690 5691 7296 5692 5693 5694 7311 5970 4851 5695 9978 7314 6500 5687 5688 2932 5689 9429 9817 4363 1029 8878 23657 5563 3417 6888 2033 3162 571 6667 4609 374 596 5154 1950 598 6347 140809 4199 7975 4097 10061 7086 1728 4780 2940 1387 84181 2729 9861 6649 8454 2730 2539 6233 8714 7316 2938 10213 5226 5706 5707 REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 96%912694 Regulation of IFNA IFNB signaling 3716 3442 3441 3440 3456 7297 11274 3452 3451 6773 3449 5781 3448 3446 8651 3445 5770 3444 3443 3454 9021 5777 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 96%2129379 Molecules associated with elastic fibres 650 3690 652 7043 4052 4053 4054 3696 4237 4238 4239 2199 8425 2192 3694 3688 8516 8076 3685 7040 27302 10516 2202 3693 30008 8200 7042 655 7448 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%71262 Carnitine synthesis 223 6470 8424 55217 PTEN LOSS OF FUNCTION IN CANCER%REACTOME DATABASE ID RELEASE 96%5674404 PTEN Loss of Function in Cancer 5728 INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling 84639 11141 8808 5599 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5674499 Negative feedback regulation of MAPK pathway 5604 5894 5605 5594 5595 673 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination 22916 84967 7884 4686 134353 79869 8189 8106 11051 10978 10898 1479 51692 1478 1477 23283 10914 53981 51585 29894 55339 81608 6628 6634 6636 6635 6637 25888 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190322.3 FGFR4 ligand binding and activation 2249 2247 2246 152831 8823 2264 9965 2254 2251 8817 26281 8074 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA 80312 200424 6996 54790 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764560 Regulation of CDH1 Gene Transcription 8331 8337 8334 8335 8341 8342 8347 8348 8345 3170 6929 8340 94234 9314 8338 7291 85236 8349 3066 6938 6591 8370 7490 54737 5594 5595 348262 5925 2146 6597 5315 7750 10009 60436 3013 7088 3065 255626 117581 3021 8289 3018 3017 11171 55810 3014 687 93986 6667 9839 474382 5931 8970 128312 387893 94239 55766 6935 8726 8968 23411 653604 1488 1487 23512 54145 5928 23028 7020 6615 7764 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9024446 LXR-mediated signaling 344 346 2874 192670 27161 2033 5346 64241 64240 2194 26523 348 6907 27329 8648 27327 9619 10062 79718 6319 23112 19 57690 1071 192669 8204 54659 8841 9682 9611 29116 80820 221656 7376 347 6256 10123 55818 9612 2172 5105 23028 6257 341 4343 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) 5708 5709 5700 5701 5702 5704 5705 5682 51686 5683 5684 5685 51582 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 5695 5687 5688 5689 1728 4947 4946 4953 9861 10213 5706 5707 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) 4804 396 4099 57142 4974 4168 84894 387 DISEASES OF THE NEURONAL SYSTEM%REACTOME%R-HSA-9675143.3 Diseases of the neuronal system 2652 5956 24 5959 145226 7276 611 64220 5950 9227 6017 5947 222236 NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism 55739 349565 133686 55191 27231 92014 54956 9390 143 93100 64802 56965 83666 79668 84875 65220 54625 4837 4907 10135 83594 55328 23057 683 952 160728 23475 128240 54981 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME DATABASE ID RELEASE 96%9672387 Defective F8 accelerates dissociation of the A2 domain 2157 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle 8826 257106 5062 11060 79834 10298 4646 2185 81839 9352 28964 8874 9146 8027 6709 9459 8440 58480 23380 1213 50618 11180 55789 10254 6714 6711 8239 50855 5295 4690 5296 57514 5058 9231 1969 667 9815 998 5063 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 96%77289 Mitochondrial Fatty Acid Beta-Oxidation 5095 284486 80221 37 55856 117145 11332 33 80724 3032 10449 84320 3030 34 414149 1666 1632 84129 4706 23597 641371 134526 1622 27349 26027 58488 51102 6296 35 1892 3033 142827 10965 5096 4594 84693 166785 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling 4804 835 836 4803 7531 27018 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair 8331 51750 54107 8337 5888 80010 8334 5889 8335 55215 8341 8342 8347 8348 8345 201254 8340 10987 8338 85236 8349 29089 7334 11200 8370 3013 3980 5423 255626 328 7515 3018 3017 7706 3014 474382 8970 128312 5536 22976 8314 55183 27343 55766 51035 10450 2070 51567 7518 8467 9031 322 79840 55775 3981 9682 64421 27434 2140 7415 2139 2138 10721 23030 57461 8178 54778 9318 6917 9100 5980 83932 10459 11201 2873 51455 9768 51138 124739 3978 9978 56949 1161 7528 55666 9716 51548 8505 54936 64858 353497 22909 9937 60 7353 11284 7157 27339 25 121642 8533 2177 2073 2176 2072 64708 85015 8607 9557 125476 10980 7874 93973 29844 54891 79913 50813 54617 10038 2067 10920 283899 79068 83444 5886 54890 221120 5887 4798 51008 84164 7507 10973 10445 7508 4350 7318 7336 1017 86 2237 9636 142 7468 29086 9025 51720 54962 91603 63967 57654 151987 84142 165918 7158 5893 5531 9577 1643 8451 79184 7320 8914 8450 56852 3838 7398 1642 6047 57599 51514 9656 378708 25898 1069 8930 6233 55247 7316 23583 252969 4968 79661 6996 7520 4913 2547 5591 8924 26277 25913 9246 2074 7979 7311 5395 4436 4437 7314 4292 2956 890 54386 7341 8554 8290 5440 5441 7013 65057 4331 7014 1022 51588 6612 2071 2966 7329 2965 6613 2068 5434 10401 5435 348654 5436 7486 5437 5981 5438 5982 5439 5983 2968 5599 8900 3364 2967 472 404672 56655 5430 5431 672 5432 675 84126 5433 144715 902 83990 5810 7516 5932 7517 9156 5111 11073 80198 641 199990 55732 55120 79008 6117 5984 5985 5424 94239 6119 5425 91442 79728 6118 5426 5427 5429 5883 57697 5884 116028 10635 4255 10714 146956 1111 197342 83695 84464 80233 10111 51426 2175 57804 4361 7156 54145 5890 5892 2188 4683 2187 580 2178 23514 63979 10524 1763 545 2189 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 96%5578997 Defective AHCY causes HMAHCHD 191 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390648 Muscarinic acetylcholine receptors 1132 1131 1133 1129 1128 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 1956 83737 10608 11033 7311 7314 3925 6285 6714 1447 4893 6654 5663 5664 3265 55851 23118 83464 5241 23385 4734 51107 2099 685 6464 2069 1839 3084 6678 2562 2561 9542 2560 10718 348 145957 2554 1950 10413 51741 6387 11059 2567 2566 6868 9611 55879 5295 6776 5290 6233 7316 2670 1742 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 3030 1892 3033 33 3032 NEUROTRANSMITTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%112311 Neurotransmitter clearance 590 220074 6532 217 43 6582 4128 6531 6580 1312 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 96%3247509 Chromatin modifying enzymes 8331 8337 440689 8334 1107 8335 93624 8341 8342 8347 8348 8345 1108 8340 23081 8338 23326 4791 83933 85236 1788 8349 51230 10765 8370 6314 5077 5978 2146 5927 7403 3013 3065 255626 6601 6603 6602 6605 11240 3018 2033 3017 3014 6907 27154 57459 474382 3054 8648 8970 128312 10499 10498 55766 79718 6604 8726 55167 8968 10933 23338 9575 10943 27097 56943 55578 9767 8841 9643 9682 9611 9913 51147 653604 221656 23522 117143 1387 84661 55818 54556 56970 11091 11143 1386 6944 8464 55929 23512 55250 79960 5928 23028 10902 5929 55257 56950 10629 55869 339287 23030 26610 23587 55140 54859 8520 8518 7994 6881 79685 6880 6883 8819 23186 8850 51742 10284 64426 25855 5926 10362 51317 196528 6871 55683 55689 284058 80314 29943 54934 353238 60 23569 10474 51702 1810 51562 26009 112869 57325 84148 9739 51412 84289 22992 51780 8242 7862 5253 23133 8284 55693 9757 84159 84678 8607 7404 3276 53615 10445 8473 64769 23774 1019 595 3066 86 9612 6595 57504 55170 6597 6599 9112 6598 63976 10856 7468 64754 84444 84787 83852 55729 121536 56979 79918 8289 84193 64324 55193 2122 6839 55870 80854 51111 79723 9869 80853 54904 29072 10196 317772 54496 79595 92815 54815 85235 387893 8969 221613 8295 55352 8089 8085 3717 6187 4790 23210 79813 57634 9219 5970 84864 10919 54014 57492 23135 2874 23067 4297 5931 2648 94239 9070 10419 79084 10524 58508 SENSORY PERCEPTION OF SOUR TASTE%REACTOME DATABASE ID RELEASE 96%9729555 Sensory perception of sour taste 133060 3759 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins 4048 246 1544 1543 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358747.4 CTNNB1 S33 mutants aren't phosphorylated 1499 5519 1452 139285 2932 5515 324 5516 5518 8312 5525 5526 5527 5528 5529 REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling 4067 3815 867 9306 6654 7525 8651 3932 10019 2534 10603 5777 5578 VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.5 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) 54716 FANCONI ANEMIA PATHWAY%REACTOME%R-HSA-6783310.6 Fanconi Anemia Pathway 64858 2067 55215 353497 22909 84126 9937 201254 7398 80198 57599 199990 55120 79008 6117 7311 6119 7314 91442 6118 29089 57697 378708 146956 197342 84464 80233 2175 6233 7316 2188 2187 2178 2177 2176 2072 2189 545 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 993 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 6500 7027 890 5687 5688 1019 595 5689 1017 898 6502 91768 7465 286826 4149 9134 132660 1027 1026 91750 1163 5753 7029 1869 55957 4331 5925 1022 1875 1874 8900 902 4609 10000 207 208 9861 8454 6233 7316 5928 10213 5934 5706 5707 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 96%9914274 3-methylglutaconic aciduria 549 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 96%5578998 Defective OPLAH causes OPLAHD 26873 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855191 Synthesis of IPs in the nucleus 51447 253430 64768 9807 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid 119548 1056 5406 8513 5407 1208 5408 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-HSA-2142688.4 Synthesis of 5-eicosatetraenoic acids 4056 240 241 5444 2877 5445 2876 5446 2879 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173623 Classical antibody-mediated complement activation 712 713 714 715 716 1401 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species 5052 7001 2877 847 54205 7295 653361 6648 475 7296 493869 79400 30001 5034 257202 9588 10935 50507 2950 6647 1536 6649 1535 318 2880 2878 2876 4688 10587 25828 2882 4689 9973 538 343 G1 PHASE%REACTOME DATABASE ID RELEASE 96%69236 G1 Phase 1029 5519 1875 1874 5515 5516 5518 902 5520 7311 4067 7314 6500 7027 1021 1019 595 1017 894 896 28227 1871 898 1870 6502 9134 1028 1027 25 1026 8454 1163 6233 5753 7029 7316 1869 4331 5925 1022 3717 5933 1032 5934 1031 1030 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME%R-HSA-5619048.3 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) 4891 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 96%5579016 Defective UGT1A4 causes hyperbilirubinemia 54657 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 96%199418 Negative regulation of the PI3K AKT network 117145 90865 118788 5155 5159 50852 4916 4233 4615 5879 5156 5728 9173 6714 7189 5781 51135 5880 146850 5594 5595 2323 2322 10818 3815 3932 10000 23533 207 208 5305 7409 6801 8503 3643 2534 5519 3630 2064 1956 7039 5515 5516 5518 8394 8395 5525 3654 5526 5527 5528 5529 2100 8396 2099 685 255324 2069 1839 930 3084 4915 4908 4909 9542 10718 627 145957 2549 374 1950 3082 57761 23396 9965 2254 2252 2251 27006 5294 5295 8074 5296 2249 2248 2247 5290 2246 152831 8823 5291 8660 5293 23035 2264 940 2255 941 942 23239 9846 3667 8817 391 8870 26281 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) 10559 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 96%202427 Phosphorylation of CD3 and TCR zeta chains 3127 3126 920 3125 3123 3122 55824 3120 3119 3932 3118 5788 5795 3115 26191 3113 915 1445 916 917 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 5296 5290 5156 5291 4893 6654 6772 3265 6774 5295 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 96%9956514 ARG1 variants cause hyperargininemia 383 EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.3 Expression of NOTCH2NL genes 1991 100996717 100996763 388677 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation 10599 3163 28234 644 645 213 3162 9429 2938 54658 54657 4363 2168 1244 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones 5443 1586 6715 6716 3293 1588 112812 2232 2230 6770 1589 147323 1585 3284 83930 3283 231 10948 79644 706 134429 1583 3294 3972 51171 3291 51170 1081 3290 441282 866 412 9256 1584 3292 51144 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME DATABASE ID RELEASE 96%9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste 50834 50837 50836 50839 50838 5726 50840 259289 259287 259286 259285 119395 3710 6324 255022 259293 259292 5330 259290 259296 259295 54795 346562 2911 2914 6330 2782 6335 29850 2784 6326 6328 6327 83756 54429 80835 51764 50831 80834 50833 50832 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer 23462 79885 3280 8850 9794 83933 7311 4851 9978 7314 6500 3066 5663 10046 5664 388585 55851 83464 23385 51107 26508 9612 9759 22938 3065 84441 1024 9734 2033 6907 4609 2648 9148 79718 28514 182 54492 57534 102 54567 6868 51564 3714 142678 8841 10013 9611 23493 10014 1387 3516 8454 6233 7316 55869 892 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER 54107 7874 2067 6917 7507 2074 7311 9978 7314 56949 1161 5440 5441 4331 1022 2071 2966 2965 2068 9716 5434 5435 5436 5437 5981 5438 5982 5439 5983 2968 2967 91603 404672 56655 5430 57654 5431 5432 5433 902 8451 8450 5111 1642 6117 5984 5985 5424 6119 5425 10450 6118 5426 5427 10714 27339 51426 57804 6233 7316 2073 57461 2072 REPRODUCTION%REACTOME DATABASE ID RELEASE 96%1474165 Reproduction 8331 8337 5888 8334 5889 8335 8341 8342 8347 8348 8345 8340 8338 85236 8349 1019 1017 8370 3013 255626 8320 56979 64321 3021 3018 3017 3014 9126 9985 27127 474382 10734 50511 93426 10388 8970 128312 23345 23224 256126 2683 56158 6847 55766 644186 23353 8968 653604 7852 7022 10735 342977 9139 4001 10274 26277 8243 25913 5885 4292 54386 7783 378807 11085 49 7784 22917 8290 100129669 157855 257062 117144 7013 84329 65057 7014 284359 5016 57828 8747 54790 57829 7329 8748 347732 126123 2515 117155 79820 113177 928 652 472 672 675 5932 3306 641 55732 6117 11144 23626 25777 94239 6119 29893 27030 84057 6118 4438 4439 639 10111 8468 4361 5460 7156 54145 79923 4683 6677 63979 10630 545 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8941858 Regulation of RUNX3 expression and activity 1029 5708 5709 5700 5701 5702 5704 5705 5682 5683 865 5684 64750 5685 5686 2033 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 7040 5694 7311 5695 864 7314 57154 5687 4193 5688 6714 5689 9861 6233 7316 10213 5706 5707 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 96%198745 Signalling to STAT3 4803 4914 6774 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%2408557 Selenocysteine synthesis 6222 6224 6181 6218 6217 6230 6231 6234 9349 6235 6191 6193 7311 6192 6194 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 2197 23521 140032 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6233 6207 118672 6206 22928 51091 6209 6208 6188 6301 6187 60678 6223 79048 6189 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family 7922 57181 29985 55630 25800 64116 283375 23516 29986 27173 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 96%6802948 Signaling by high-kinase activity BRAF mutants 10256 54518 8826 22866 7529 7450 3690 5604 5894 5605 5037 2243 7094 5908 369 283455 408 409 6714 4893 3265 673 4140 5594 5595 2335 2244 1445 2266 5906 7414 3674 8844 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport 55860 51164 2890 10671 8774 8775 1294 93661 22796 84516 9382 10652 3998 25839 22818 26286 22820 83548 63908 57511 10466 84342 91949 6811 830 832 11316 829 8655 11070 375056 11014 51143 9276 84364 1315 1453 1314 6396 1781 1780 1778 10540 1783 2804 26958 3630 7039 378 140735 79090 51014 5265 23423 2801 6399 5861 51272 23243 22870 2153 4253 22872 2348 10175 5537 377 10972 9554 9117 11196 64689 126003 55291 6708 10121 6709 23256 1075 58485 254263 25956 55014 81562 1639 286 51693 2157 287 288 122553 8615 966 51332 10342 27095 6711 149111 6710 9919 372 81876 6712 83696 381 10959 10113 9527 90411 10282 26984 11015 9570 51399 89866 8729 79748 7109 128637 54732 10960 51226 57731 375 1522 51128 374 55738 9871 9632 10427 4905 11258 10945 10802 10484 1604 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN 64840 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME%R-HSA-5632987.2 Defective Mismatch Repair Associated With PMS2 5395 4292 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%391908 Prostanoid ligand receptors 6915 5729 11251 5731 5737 5739 5732 5733 5734 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 96%379401 Clearance of dopamine 220074 4128 6531 1312 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 96%68867 Assembly of the pre-replicative complex 8331 8337 8334 51529 7321 8335 8881 64682 25906 11065 8697 7324 84515 5000 10393 29945 8341 5001 27338 23594 119504 8342 23595 29882 4998 8347 4999 8348 246184 8345 996 51434 51433 8340 8338 85236 8349 81620 51343 51053 8370 23633 3013 255626 3021 3018 3017 3014 3837 474382 8970 128312 55766 8968 653604 9861 6233 7316 10213 5706 5707 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 4172 5714 4173 7979 4174 5690 4175 5691 4176 5692 5693 5694 7311 4171 5695 7314 5687 5688 5689 990 94239 54145 3836 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation 8682 3716 1849 3569 1848 1846 5604 5605 7297 3570 1852 1850 5781 11221 1844 1843 1847 983 5594 5595 80824 3717 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 96%5619060 Defective CP causes aceruloplasminemia (ACERULOP) 1356 30061 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%3296197 Hydroxycarboxylic acid-binding receptors 27198 8843 338442 MDK AND PTN IN ALK SIGNALING%REACTOME%R-HSA-9851151.1 MDK and PTN in ALK signaling 5803 5764 238 4192 PPARA ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-1989781.6 PPARA activates gene expression 6822 26230 10001 3158 51129 29079 10062 19 116519 336 9612 9862 183 90390 2168 948 84498 9967 1374 376497 55588 80306 96764 4899 2033 11010 6907 80205 335 8648 10891 4862 4199 51003 10499 10498 79718 6604 133522 9575 84246 8841 9611 9572 1387 9443 1579 23054 9412 5469 9441 85441 9442 406 27063 1376 9440 8202 9915 51586 2274 54600 400569 9439 55090 23097 34 57491 196 3992 50486 6837 9477 27242 7296 1543 112950 29841 81857 219541 7376 6256 5465 54797 6095 2101 5468 8800 2874 5244 1024 23389 9282 2180 2222 3157 6667 9968 9969 4800 4801 4802 9971 1581 57761 6721 4520 405 10025 211 123 6257 23179 892 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 96%72202 Transport of Mature Transcript to Cytoplasm 23636 22916 5903 9972 9631 7175 11097 4686 23511 8086 8021 53371 8480 10762 79902 8189 10898 51692 9785 6430 6432 6431 53981 9984 10250 29894 29107 55339 22794 81608 57187 51362 7919 199746 1977 84324 84248 6427 6426 84321 6429 9939 6428 10212 728343 9877 51213 10189 84271 65109 80145 26097 8563 8683 10482 7884 9775 9295 10921 10569 11338 2733 55110 79228 4116 7307 348995 57122 55746 23279 79023 6396 9883 129401 9688 23225 4927 23165 55706 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism 79178 60386 10560 80704 27010 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 96%5545483 Defective Mismatch Repair Associated With MLH1 5395 4292 GLYCOSPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9840310.3 Glycosphingolipid catabolism 339221 57704 4074 56624 285362 79642 57733 5476 112937 6609 3074 25870 3073 10825 2717 79411 340075 2720 411 410 412 427 89944 2760 414 415 416 5660 22901 6610 153642 55512 347527 4758 55627 4759 2581 2629 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion 2158 DEFECTIVE MPI CAUSES CDG-1B%REACTOME%R-HSA-4043916.4 Defective MPI causes CDG-1b 4351 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME DATABASE ID RELEASE 96%9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex 1387 4297 5187 1454 8864 1453 8863 406 9575 1408 1407 4862 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 96%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 3030 34 1892 3033 3032 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975578.5 Reactions specific to the complex N-glycan synthesis pathway 64377 4124 2517 2525 4122 2530 4247 3972 9486 1081 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665348 Signaling by ERBB2 ECD mutants 2064 1956 4893 6654 3265 5295 3320 55914 5290 5335 2549 6464 1950 11140 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 96%5627083 RHO GTPases regulate CFTR trafficking 1080 57120 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 96%4793952 Defective MGAT2 causes CDG-2a 4247 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%70326 Glucose metabolism 23636 5903 9972 54020 9631 7175 5519 11097 2646 23511 8086 8021 53371 80201 8480 10762 5515 5566 5516 5518 2821 2597 79902 3101 5528 226 83440 387712 229 2023 5091 5230 7167 5105 2027 2026 92579 5567 5568 348995 230 5210 57122 5211 2645 5213 10007 2542 669 26330 57818 5207 55746 5208 5209 3099 5223 3098 5224 23279 79023 283209 6396 5214 5232 2203 9883 129401 132789 9688 8789 2538 23225 4927 23165 5106 55706 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 96%428542 Regulation of commissural axon pathfinding by SLIT and ROBO 9353 6092 4753 6091 6586 6585 1630 6714 9423 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function 24 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702577 semaxanib-resistant FLT3 mutants 2322 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9692916 SARS-CoV-1 activates modulates innate immune responses 5478 64135 23586 834 340061 80143 4790 57506 861 4792 83737 7706 3837 11035 3838 29110 3661 11123 7311 5970 7314 51284 684 9111 10465 7187 5479 9641 7189 9360 29108 9868 114548 26007 6233 6441 7316 3656 5094 2280 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state 8452 5708 5709 5700 5701 5702 5704 5705 5682 5683 8650 408 5684 83737 409 64750 5685 5686 5717 5718 5719 11047 5713 5714 7979 79577 5690 5691 5692 5693 5694 7311 5695 9978 7314 5687 5688 5689 50937 64399 91653 2619 6469 22873 51684 25989 339745 132884 2121 23288 2622 84455 50846 11127 6608 156 2737 2736 8405 374654 23432 2735 57154 1452 3549 9861 6233 7316 10213 5706 5727 5707 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%418346 Platelet homeostasis 808 10242 5519 6786 6543 5739 3708 3709 5515 5516 5518 3778 3779 5525 5175 5526 7804 5527 5528 5529 4843 2793 5023 2792 5024 2791 2790 2983 9127 5026 2982 22953 5781 2788 2787 1432 2786 2977 2785 2784 2783 51764 5777 94235 5152 10335 55970 5025 54331 5051 5321 59345 2268 10846 5153 50940 5136 338 6546 5027 7222 4842 5593 6547 5138 3710 7225 80228 487 488 2782 57113 489 84876 27094 2778 4846 6717 27345 490 491 10681 492 493 8654 CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance 348 26119 3990 338 3949 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation 51586 9439 400569 55090 4790 688 10001 23097 1050 6837 9477 9314 51129 7040 112950 29079 5970 4023 1019 81857 7480 896 219541 6256 5465 54797 9612 5105 9862 90390 168544 1879 3952 5468 10974 27332 2167 1959 948 84498 9967 7026 55588 1024 1051 80306 96764 23389 2033 5346 9282 1052 6907 9968 80205 9969 9370 8648 10891 51003 10499 10498 6517 79718 6604 6721 84246 8841 9611 1387 9443 7471 23054 5469 9441 9412 85441 9442 10025 9440 8202 7124 892 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function 580 672 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%392851 Prostacyclin signalling through prostacyclin receptor 55970 2793 2792 2791 5739 2790 2788 2787 2782 2786 54331 2778 2785 59345 2784 2783 10681 51764 94235 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) 112755 6616 6804 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME%R-HSA-5579009.5 Defective CYP11B2 causes CMO-1 deficiency 1585 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) 3776 54207 50801 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 54107 142 5423 328 5981 5982 8505 5983 54936 10038 56655 3978 5111 6117 5984 5985 5424 6119 5425 6118 5426 5427 10714 2237 57804 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME DATABASE ID RELEASE 96%5619097 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) 142680 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9764562 Regulation of CDH1 mRNA translation by microRNAs 999 23112 4613 26523 57690 4609 192669 192670 27161 27327 4343 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 96%4839726 Chromatin organization 8331 8337 440689 8334 1107 8335 8313 93624 8341 8342 8347 8348 8345 1108 8340 23081 8338 23326 4791 83933 85236 1788 1499 8349 51230 10765 8370 6314 5077 5978 2146 5927 29117 7403 3013 3065 255626 6601 6603 6602 6605 11240 3021 3018 22827 2033 3017 3014 3481 6907 27154 10262 80205 57459 474382 3054 11325 8648 8970 128312 7975 10499 22850 10498 55766 23394 79718 6604 8726 55167 8968 10933 23338 9575 10943 27097 4780 56943 55578 9767 8841 9643 9682 9611 9913 51147 653604 221656 23522 2203 117143 1387 84661 55818 54556 9879 56970 11091 11143 1386 6944 8464 55929 23512 1105 55250 79960 5928 23028 10902 5929 55257 56950 10629 55869 339287 23030 26610 23587 84844 55140 54859 8520 8518 7994 8175 6749 6881 79685 6880 6883 8819 11198 23186 10992 6929 8850 51742 10523 10284 64426 25855 10951 5926 10362 51317 6627 6629 23450 23451 6938 6638 85409 79843 55636 196528 5105 6871 55683 55689 51639 284058 80314 29943 54934 353238 60 23569 10474 51702 1810 10291 51562 26009 112869 57325 84148 23350 10285 1106 9739 10946 51412 84289 1665 84991 83443 22992 51780 8242 7862 5253 23133 8284 55693 9757 84159 84678 8607 7404 3276 53615 11335 10445 23168 79577 8473 64769 80349 23774 123169 9646 1019 595 54623 3066 86 9612 6595 57504 55170 6597 6599 9112 6598 63976 7182 10856 7468 64754 84444 8110 84787 83852 8193 26039 55729 121536 5977 56979 79918 6760 8289 84193 64324 55193 2122 9274 6839 27123 9275 55870 605 80854 51111 79723 9869 80853 54904 29072 10196 317772 54496 79595 92815 54815 85235 387893 8969 221613 8295 55352 57680 10664 1728 53335 84181 8089 8085 2538 23506 65980 3717 29998 6187 6925 4790 4654 4656 23210 79813 57634 9219 5970 84864 10919 7341 114825 125997 170394 85509 54014 57492 8099 26038 55205 23135 7329 6941 22806 22807 57592 23613 10263 8932 9640 7026 10320 152485 84295 2874 23067 4297 5931 2648 94239 9070 6632 10419 6628 79084 6634 6633 6636 54145 6635 6637 55274 64919 10524 58508 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) 3098 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m 22845 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 96%3928663 EPHA-mediated growth cone collapse 4067 6093 4628 79784 10398 4629 387 7525 9475 25791 2534 103910 4627 4637 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects 1029 1021 1019 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome 27350 29974 164668 403314 200315 339 9582 10930 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 7321 9349 7322 51121 11224 200916 6122 6124 6123 6125 25873 140801 4736 6130 6133 6132 6135 6134 6137 6136 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 23521 6164 6166 6165 6168 6167 6169 116832 6160 8453 6161 6175 9045 6176 7415 6171 6170 25898 6173 9861 6233 7316 10213 5706 5707 5708 5709 6181 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 26046 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 6921 5695 9978 7314 6923 5687 5688 5689 22980 9147 23008 55139 55666 7353 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription 30818 6722 2908 5978 CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.8 Cilium Assembly 57576 983 5347 6010 1258 55835 8655 10142 23332 22919 3320 5048 6991 64792 7840 6753 92104 9742 11064 23322 22994 22995 7283 27241 203068 55722 1453 54820 7532 9738 80776 79659 11190 5310 5311 261734 1781 23059 22920 95681 55212 51098 1778 117177 1069 28981 5577 403 51134 54801 9793 10540 51259 54806 4218 4735 79809 26160 11116 23265 92482 83657 150737 84902 84747 200132 83658 54930 7531 378 140735 60412 84100 5566 79959 54536 51668 5518 4867 2847 93323 9657 91147 22981 9371 55112 27077 80254 55755 10806 26146 85302 10121 10640 57539 11336 129880 89891 9662 149371 347240 11020 1262 55081 1260 22832 57787 6950 57545 7203 10733 80321 123016 55764 55125 55763 9814 3797 79738 8729 10694 8100 112752 10576 26005 115106 10575 166379 79441 55770 79600 26123 9702 79969 3842 5108 9321 50807 57560 55142 10383 22897 8195 10382 79598 5116 56912 80184 255758 11127 7846 6608 57728 51626 132320 6102 90410 8766 23354 146057 8481 582 583 54585 585 27031 121441 192668 79867 79989 7277 9727 55559 1454 22948 8636 4751 11258 84131 80173 54903 4957 10013 56623 5147 200894 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 96%9937383 Mitochondrial ribosome-associated quality control 64432 65003 64951 65005 65008 28977 90480 51081 6150 55168 64949 28973 65080 51642 5018 54998 10573 11222 128308 51649 9553 64960 92259 63875 64963 64965 64968 55173 55052 64969 51373 26284 51650 60488 51253 51258 219927 29074 56945 64975 28998 64976 79590 64979 64978 23107 28957 64928 7818 57129 51263 29088 51021 54534 51023 51264 51069 84545 78988 122704 65993 64981 10240 64983 3396 26589 63931 6182 54460 6183 118487 51073 4706 116540 740 124995 54148 116541 55037 29093 9801 54471 51116 10884 54948 51318 91574 51250 115416 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling 5335 4803 4914 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 96%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P 6888 SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions 3672 23129 6093 4628 10398 79784 10507 6237 388 3984 2064 3985 5062 56896 7094 8851 1020 9475 57556 971 3326 5364 3688 10371 5788 1808 2242 64218 4233 10570 389 5879 54209 5362 9723 4629 2932 5365 7305 55558 1809 10154 8482 1072 1400 80031 103910 4637 9855 9037 3320 91584 5361 23396 27289 387 23365 5058 9826 8829 2534 2909 4627 5063 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 126410 CHYLOMICRON REMODELING%REACTOME%R-HSA-8963901.2 Chylomicron remodeling 344 345 336 4023 337 348 338328 335 116519 338 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%112310 Neurotransmitter release cycle 2572 2571 60482 6511 27165 6506 6505 6507 6844 6512 6616 3312 6539 6857 6804 55327 54407 22999 8541 18 1103 27163 140679 7915 8224 5864 2744 80331 6854 6853 8497 8499 10815 10497 4128 6529 8825 9256 6540 8573 6538 8500 57030 6571 6572 10550 320 6582 6580 64130 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation 808 857 115677 23576 114757 340481 80777 10434 207 4836 6697 3320 9397 1785 4846 51070 8976 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen 9562 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 2864 9630 2769 5330 5331 23236 2767 2776 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 5708 5709 5700 51529 5701 7321 5702 5704 8881 64682 5705 25906 11065 5682 8697 5683 7324 5684 10393 29945 27338 5685 119504 5686 29882 5717 5718 246184 5719 983 996 11047 51434 5713 51433 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 890 5687 5688 5689 9184 991 8900 4085 4751 701 9861 6233 7316 10213 5706 5707 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants 3815 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME%R-HSA-9916720.1 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 1892 M PHASE%REACTOME%R-HSA-68886.5 M Phase 8331 8337 8334 51529 7321 8335 8881 64682 25906 11065 1104 8697 7324 10393 29945 8341 27338 119504 8342 8347 29882 8348 891 246184 8345 7443 983 9798 996 51434 22933 51433 8340 221496 200014 5347 2010 9700 260334 6683 347688 8338 23141 85236 8349 85378 64151 10426 10592 29922 27229 9918 23397 440145 80097 10051 4926 114791 27175 23592 653784 10844 9663 8370 5594 3013 255626 64900 23175 3021 3018 3017 3014 5520 474382 8970 128312 7514 55766 8968 7532 26271 653604 5577 4001 7531 2801 113457 140609 10783 91754 7280 10376 80086 51807 10381 10383 10382 112714 7846 84790 84617 347733 7277 7278 81027 79861 9883 129401 9688 23225 4927 23165 55706 92421 23636 9972 9631 27243 7175 11097 128866 23511 8086 8021 53371 8480 10762 8815 79643 51652 29082 91782 25978 55835 5925 54908 6232 8655 25909 8379 9183 23047 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 10142 23332 79003 55055 81565 3320 22919 113130 348995 348235 3837 9126 5048 23421 57122 220134 57082 57405 7840 147841 51143 6249 5578 11064 55746 387893 4085 22994 9133 22995 64105 7283 401541 23279 203068 79023 10776 10403 55722 1453 79648 54820 9738 80776 5862 701 255919 11190 54821 84930 6396 2029 55844 378708 5901 54892 1781 23122 23310 23244 25836 95681 23383 1780 27436 8548 79172 23399 1778 29781 81930 10735 1069 26003 9861 55920 84643 6233 3796 7316 54801 9793 10540 91687 5579 57551 79682 10213 5905 5706 1783 5501 5707 83540 5708 11116 80152 5709 5903 2491 10112 5519 5700 332 5701 55143 9493 5702 27183 23063 5704 699 5705 11243 54930 10274 5682 140735 5683 3619 5515 5566 11004 5684 79959 5516 5861 5518 5685 9212 5686 25936 5717 8243 93323 5718 11130 5719 64946 22981 79980 11047 10726 5713 79902 5714 5885 5525 7979 80254 5526 5690 55755 55839 64689 5691 10806 5527 5692 5528 5693 5529 5694 10121 7311 5695 7314 9662 5687 5688 5689 8615 7341 81876 10733 80321 55125 8290 9814 3930 6418 115106 79441 7329 9702 3842 5108 55142 22897 5116 80184 1460 1459 1457 23354 8481 55732 121441 94239 55559 1454 8636 4751 11258 84131 4957 9232 54145 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975957.3 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6230 6231 6234 9349 6235 6191 6193 6192 6194 51121 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6232 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 23049 6158 23293 9887 2197 55181 23521 23381 55629 140032 56006 5520 6164 6166 6165 6168 6201 6167 23708 6203 6169 6202 116832 6160 6161 2107 55802 26986 6175 9045 2935 6210 6176 6171 6170 6173 51065 26019 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 6222 22916 6224 6181 6218 6217 4686 65110 5515 5518 7311 22794 1981 9939 65109 9775 10921 55110 4116 5976 GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly 2697 2706 127534 219770 125111 375519 2702 57369 2701 10052 2700 84694 2709 2707 2703 10804 57165 81025 2705 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%426496 Post-transcriptional silencing by small RNAs 23112 26523 57690 192669 192670 27161 27327 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus 100996717 100996763 388677 4853 7311 7314 9148 28514 1272 182 54492 57534 102 54567 5663 142678 3714 5664 55851 83464 23385 51107 6233 7316 4192 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 96%196299 Beta-catenin phosphorylation cascade 23401 1499 5519 1452 139285 2932 5515 324 5516 5518 10023 8312 5525 5526 5527 5528 5529 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 96%166020 Transfer of LPS from LBP carrier to CD14 929 3929 MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51434 51433 5347 54908 6232 8655 25909 8379 9183 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 348995 348235 5048 23421 57122 220134 57082 57405 147841 51143 6249 55746 7514 4085 64105 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 1781 23122 1780 79172 1778 81930 55920 84643 3796 9793 91687 57551 79682 5905 1783 5501 83540 80152 5903 2491 5519 332 55143 699 11243 140735 3619 5515 11004 5516 5518 9212 25936 11130 64946 79980 10726 79902 5525 5526 55839 5527 5528 5529 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE 10162 123745 79887 5319 255189 5920 50640 50487 22925 64600 100137049 254531 30814 5321 63874 57110 8399 5320 154141 5322 26279 283748 81579 8398 129642 117245 8605 54979 11145 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME%R-HSA-9656249.3 Defective Base Excision Repair Associated with OGG1 4968 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 96%196843 Vitamin B2 (riboflavin) metabolism 5167 55312 54 80308 55065 79581 113278 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 96%9754706 Atorvastatin ADME 10599 5444 5446 28234 54659 1576 5243 1244 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 96%9938206 Developmental Lineage of Mammary Stem Cells 2255 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 96%8951936 RUNX3 regulates p14-ARF 864 2033 3845 595 861 6046 865 9759 7040 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance 346 3069 51599 55911 3988 348 26119 335 81693 338 255738 10577 7311 10062 7314 1213 8029 1211 160 161 163 23491 29116 57552 8435 7436 7376 4864 6646 6233 7316 3990 1175 1173 341 3949 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%9637628 Modulation by Mtb of host immune system 4360 7314 567 6233 7316 7097 7311 WAX BIOSYNTHESIS%REACTOME%R-HSA-9640463.3 Wax biosynthesis 84188 55711 158835 158833 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System 114609 695 948 710 1147 6271 3818 2161 2147 2243 4790 7097 7096 4792 23643 4791 4615 5970 81622 7098 3551 51284 7099 8517 929 7187 148022 3146 51135 7100 6279 6280 10333 81793 2244 2266 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 6801 57599 81608 REGULATION OF TNFR1 SIGNALING%REACTOME%R-HSA-5357905.8 Regulation of TNFR1 signaling 1147 7132 7321 7332 841 8737 10616 329 29110 7186 10273 7311 7323 330 331 7314 7322 3551 9099 27005 220213 7185 8517 56957 7375 9641 84888 55072 142678 8408 81858 25999 90268 1540 9261 9825 8717 10133 8887 7128 56928 10399 6233 7316 7124 8772 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%6783984 Glycine degradation 4967 92259 275 1738 2653 2731 1743 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 5708 5709 5700 5701 5702 5704 5705 5682 5683 472 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 7314 7157 5687 5688 64326 5689 9861 6233 7316 10213 5706 5707 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) 6578 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 96%8953854 Metabolism of RNA 81608 57794 9238 60493 22826 23049 22827 23293 9887 55181 23381 55629 56006 10262 54883 11325 10236 55749 23524 10450 57703 10465 53938 207 10128 24148 81892 55149 23020 55006 85313 9879 9410 9416 10181 51340 5093 5094 51593 57461 84844 25904 22916 27238 4686 8175 51729 55571 51503 55696 10992 246175 5725 10523 10284 4670 988 8189 11051 10978 6627 1479 6629 220988 51692 1478 1477 23283 23450 10914 23451 53981 56949 51585 5546 29894 55339 6638 10594 5356 677 3178 3181 3188 3187 3185 3184 9716 51095 3191 22803 3190 51639 8896 51645 64895 23144 1797 124245 85437 154007 54439 11066 91746 8233 10081 10084 10179 55687 84186 79622 10291 87178 55599 23211 64172 64848 6499 55954 55596 79693 56339 196441 8449 64062 6832 64282 25996 25821 3315 57721 10283 9589 80335 8241 84705 23350 10286 10285 9343 56259 10946 10907 9360 10528 27339 1665 84991 9883 129401 2521 9688 83443 60528 23225 4927 23165 55706 23636 10642 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 6230 6231 6234 9349 6235 6191 80349 6193 6192 6194 10898 22985 51121 6227 6229 6228 51602 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 6132 6135 6134 6137 6136 6128 3192 6129 6142 6141 6144 6143 6146 9652 6147 10767 3304 115024 28960 6139 6138 104 6152 6155 6154 6157 6156 6159 6158 2197 11044 23521 140032 6164 6166 6165 6168 5578 6201 6167 8106 6203 6169 6202 116832 6160 6161 1453 5901 23019 6175 9045 6210 6176 6171 6170 6173 51065 6205 9861 6204 6207 6233 6206 7316 2926 6209 10213 6208 25888 6188 5706 6187 6223 5707 6189 5708 6222 5709 6224 6181 6218 5700 6217 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 9584 6631 5694 7311 10929 57472 10772 6625 5695 6626 7314 135295 64852 5687 9785 10915 58517 5688 6430 6432 27336 5689 6431 55660 5511 9984 5514 10250 29107 22794 57187 51362 7919 199746 84324 84248 6427 6426 29883 84321 6429 9939 6428 10212 728343 9877 51213 10189 84271 65109 80145 26097 8563 8683 3842 10482 9775 9295 10921 10569 11338 2733 55110 79228 4116 7307 1454 4839 4850 4848 4849 5393 11340 22894 103 23016 8570 23404 5073 51010 54512 51013 56915 118460 9261 113179 1432 4234 8270 134637 79691 81605 54974 55644 7534 55621 51002 9836 84267 81890 84520 5600 91801 152992 57604 22938 51605 54517 7529 93587 115708 90353 5499 63892 57570 221078 54482 348180 127253 129450 23536 1787 96764 55253 5500 24140 55039 60487 54901 4691 54802 54888 23318 2058 54920 387338 5520 83480 10785 54931 79670 22868 26995 51335 81554 219988 51106 7514 23658 9692 23708 51001 25804 27258 55178 79922 23644 3028 54464 10605 130916 51690 9924 1656 84881 255967 196513 285367 27257 29960 167227 2107 55802 11157 57819 26986 80153 2935 11193 24144 8899 55100 143884 23398 3550 26019 9092 55234 8559 58509 6936 59286 79576 6434 51691 151903 10713 55702 1655 5411 153527 60625 3183 84811 65110 11017 84950 5930 9128 9129 26017 7737 63932 9130 4236 79706 84081 25949 27316 79171 1659 55094 79869 79165 26121 163859 79753 7536 51747 51634 51759 1975 1977 1981 84967 7884 134353 3312 27350 29974 164668 5976 403314 51504 200315 339 9582 10930 11260 1653 51367 10775 80746 79042 51493 10940 339487 79074 283989 283742 116461 10248 51637 85456 9337 1974 1973 10644 10643 6232 9125 4904 91603 348995 5580 57122 55746 23279 79023 6396 112858 1660 5903 51428 5515 5518 79902 9188 23160 79897 92856 54913 5394 28987 8780 51096 5822 115939 114049 81875 57647 55226 90459 7538 10199 8568 22984 1994 5440 11056 8125 705 5441 8741 57418 6418 8732 10885 4331 8731 10171 1022 23246 84916 2071 6829 27043 27042 2966 23759 23481 2965 55127 2963 84128 2962 2068 51202 55131 5434 5435 9790 81887 5436 5437 55813 27292 5438 5439 56902 84946 2968 117246 2967 83732 404672 5430 88745 55272 5431 10969 5432 10607 5433 84135 902 51118 10813 55720 11102 11103 65083 1736 25879 54881 26168 27340 27341 79159 55623 51388 55505 9136 55759 134430 79707 79050 4809 54555 54433 26354 8602 9277 55651 50628 6632 2091 10419 25926 6628 10799 10557 51808 10436 79084 79760 10438 55781 54960 6634 10556 6633 23517 6636 57050 6635 51077 6637 9724 25929 10200 10073 79833 6607 8487 11218 1207 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) 551 552 553 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5668541 TNFR2 non-canonical NF-kB pathway 5708 5709 1147 7132 7133 5700 5701 5702 5704 5705 5682 959 5683 5684 5685 356 5686 5717 329 5718 5719 8945 11047 5713 5714 7186 7979 5690 5691 5692 5693 4791 5694 7311 330 5695 7314 6500 5687 5688 5689 7187 8741 4982 608 9039 8995 10673 23495 7293 7292 60401 9040 8784 8600 9966 128178 115650 8718 9020 8740 8744 8742 8771 8792 51330 939 943 944 970 4055 4050 5971 4049 10913 9861 1896 8454 3604 8764 6233 7316 10213 5706 7124 23291 5707 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 96%5690338 Defective ABCC6 causes PXE 368 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%4419969 Depolymerization of the Nuclear Lamina 4001 64900 255919 23592 23175 23399 891 9663 983 221496 2010 5579 5578 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6787450 tRNA modification in the mitochondrion 55006 3028 55687 54802 64172 79693 54931 25821 9692 84705 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 96%3359471 Defective MMAB causes MMA, cblB type 326625 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants 5296 5290 5156 5291 4893 6654 6772 3265 6774 5295 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins 4048 240 246 ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling 10256 808 817 54518 818 4763 8826 22866 7450 3690 399473 5894 5037 22808 2243 161742 7094 200734 5908 369 8036 283455 408 10018 409 10533 6714 4893 3265 673 4140 5594 5595 80824 5906 3674 1849 1848 7529 1185 5604 27044 5605 23164 8805 8546 57670 10827 10142 54845 56829 9444 9061 5500 57085 9715 11044 55109 4000 22906 8087 55750 80853 3845 1852 1850 11221 4296 8315 2335 5245 3717 2244 1445 2266 5501 7414 815 8844 816 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME%R-HSA-5632928.2 Defective Mismatch Repair Associated With MSH2 4436 4437 2956 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 96%2024096 HS-GAG degradation 6382 3339 2719 4669 10855 221914 2262 9672 1514 6448 2239 60495 2817 6383 3425 10082 6385 375790 3423 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME DATABASE ID RELEASE 96%5619072 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) 7355 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.3 Defective cofactor function of FVIIIa variant 2159 2158 2157 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling 107 5567 108 109 5568 5575 5566 5573 111 112 2778 113 5577 114 115 5576 196883 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 96%8984722 Interleukin-35 Signalling 3716 6775 3572 3595 9466 821 3592 7297 3717 6772 6774 10148 PROTEIN LIPOYLATION%REACTOME%R-HSA-9857492.1 Protein lipoylation 11019 2230 1737 27247 4706 1629 387787 2653 1743 51601 TGFBR1 KD MUTANTS IN CANCER%REACTOME%R-HSA-3656532.4 TGFBR1 KD Mutants in Cancer 4087 4088 7046 7048 7040 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism 161823 5105 22978 124 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling 1650 6285 6288 6283 351 3146 5589 830 5594 177 5595 829 3958 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960525 CASP5-mediated substrate cleavage 3553 836 3606 838 79792 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-HSA-75876.10 Synthesis of very long-chain fatty acyl-CoAs 11000 54898 83401 197322 51703 6785 79071 2182 3293 81616 2181 51495 60481 2180 9200 9524 64834 401494 23205 23305 79993 253017 201562 51144 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9818025 NFE2L2 regulating TCA cycle genes 4199 4780 3417 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair 85015 8607 54107 9557 125476 7874 10980 93973 29844 54891 79913 50813 54617 10038 2067 10920 283899 83444 5886 5887 4798 7507 10445 7508 10987 7336 7334 86 3980 142 7515 91603 57654 1643 8451 8450 1642 10450 1069 6233 7316 57461 8178 54778 9318 6917 2873 51138 3978 2074 7311 9978 7314 56949 1161 7341 8554 5440 5441 4331 1022 2071 6612 7528 2966 7329 2965 6613 2068 9716 5434 5435 10401 5436 5437 5438 5981 5439 5982 2968 5983 2967 404672 56655 5430 5431 5432 5433 902 60 5111 6117 5984 5985 5424 6119 5425 6118 5426 5427 10714 27339 51426 57804 8533 2073 2072 64708 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription 8331 7004 8337 7003 8334 7005 8335 2353 4790 8341 8463 8342 8347 8348 8345 8340 3725 2354 8338 4791 85236 5970 1499 8349 23476 2034 8370 2146 3013 255626 6772 6774 3021 3018 2033 3017 3014 4297 4609 474382 5931 8970 10413 128312 3091 83439 94239 55766 9070 8726 4613 8968 4780 3727 51176 3659 653604 1387 84661 11091 25937 23512 54145 5928 5929 6932 467 6934 58508 SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655253 Signaling by FGFR2 in disease 2963 22916 2962 5434 5435 4686 5436 5437 5438 5439 5430 5431 5432 5433 2263 5335 2549 4893 6654 2254 3265 2252 2251 27006 8074 5295 2249 2248 2247 2246 5290 8823 5440 5441 2255 10818 8817 26281 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 96%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) 6530 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation 2160 2158 2812 2815 2811 2814 GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling 2770 3678 2781 55970 2773 107 5567 108 109 5568 5566 111 54331 2852 112 113 3688 114 59345 115 2793 6714 2792 346562 2791 5575 2790 5573 2788 2787 2782 2786 2785 5577 2778 2784 5576 2783 10681 51764 196883 94235 2771 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) 5277 5279 84720 5283 23556 5281 93183 284098 84992 54965 55650 80235 9487 9488 51227 54872 8818 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654704 SHC-mediated cascade:FGFR3 2249 2247 2246 8823 4893 6654 2254 3265 8817 26281 8074 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions 3910 3691 3911 3912 3673 6382 3690 3655 9672 780 5155 3688 4921 87 7057 7040 7402 3339 3693 7276 59277 1821 3371 51399 137868 1756 5154 6645 3685 1838 1837 6641 5578 6443 6640 9378 6442 6445 6444 8082 54221 8910 1605 8573 2247 3913 3914 3915 3918 284217 6383 10319 6385 3908 375790 3909 7448 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 63970 94241 84883 7157 7159 8626 665 10650 581 472 147923 51499 637 55240 7161 23368 1387 27113 27166 5366 KW2449-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702569 KW2449-resistant FLT3 mutants 2322 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 96%69231 Cyclin D associated events in G1 1029 5519 1875 1874 5515 5516 5518 902 5520 7311 4067 7314 6500 7027 1021 1019 595 1017 894 896 28227 1871 898 1870 6502 9134 1028 1027 25 1026 8454 1163 6233 5753 7029 7316 1869 4331 5925 1022 3717 5933 1032 5934 1031 1030 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA 6790 22822 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome 1655 85437 7428 5925 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism 8612 125981 81537 222 130367 8879 340485 8613 55331 221 8611 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) 8671 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm 7004 1499 3169 4087 4088 8928 344022 51176 8463 6862 3170 6469 6932 10413 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria 572 7529 7532 7531 207 208 2810 637 5533 7534 596 10971 7533 10000 5534 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963898 Plasma lipoprotein assembly 344 345 5034 346 19 5567 5568 2 5566 336 29801 337 348 4547 51128 335 338 341 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 3002 2208 84441 100996717 100996763 388677 3280 2033 4853 9794 7311 7314 9148 28514 1272 182 54492 57534 102 54567 5663 142678 3714 10046 5664 388585 55851 83464 23385 51107 3516 6233 7316 4192 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME%R-HSA-174495.3 Synthesis And Processing Of GAG, GAGPOL Polyproteins 55048 89853 7314 155382 137492 93343 7251 51271 79720 9397 6233 7316 7311 51160 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME DATABASE ID RELEASE 96%9682706 Replication of the SARS-CoV-1 genome 1655 85437 7428 5925 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 96%5609974 Defective PGM1 causes CDG1t 5236 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8934593 Regulation of RUNX1 Expression and Activity 23112 1021 57690 6714 595 192669 861 894 5371 896 865 192670 5781 27161 26523 27327 4343 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME%R-HSA-5654227.4 Phospholipase C-mediated cascade; FGFR3 2249 2247 2246 5335 8823 2254 8817 26281 8074 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9969896 Lanosterol biosynthesis 6713 4597 9453 4047 3422 4598 2224 2222 3157 403313 39 10654 91734 DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME DATABASE ID RELEASE 96%9930449 Defective cleavage of FV variant at a.a.534 5624 2153 5627 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids 347 376497 389812 3933 286256 10999 28965 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 96%4687000 Defective MPDU1 causes CDG-1f 9526 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 96%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 4129 4128 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME%R-HSA-4720489.4 Defective ALG12 causes CDG-1g 79087 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 96%75944 Transcription from mitochondrial promoters 5442 64216 7978 7019 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress 8894 1968 115209 11331 27102 9812 30968 10730 1965 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway 10001 8678 8341 29079 929 9862 90390 9636 64135 3442 3441 3440 23586 5499 55588 57506 3452 3451 3449 80306 3448 3446 3445 3444 5500 2033 3320 3443 7706 23643 3837 4691 3480 1524 5610 5878 90701 5868 5869 4131 7514 3716 51003 7098 51284 7099 84246 28972 1387 9443 9412 5469 9441 9442 6233 7316 23478 6383 10082 9440 6385 5501 51586 6382 400569 9439 7297 1956 55090 7097 6773 221914 23097 9672 3326 2239 3454 9246 6837 9477 112950 7311 10134 6921 9978 7314 5045 3339 6923 81857 219541 2262 25820 54797 10332 10333 2817 8065 2719 3456 3312 1024 51191 23389 9282 1460 1459 9789 1457 9968 3661 9969 60559 4939 30835 10025 375790 892 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 96%1247673 Erythrocytes take up oxygen and release carbon dioxide 6521 3043 759 3040 760 762 358 6005 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 96%112126 ALKBH3 mediated reversal of alkylation damage 221120 51008 84164 10973 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 96%9759774 Diseases of mitochondrial beta oxidation 4594 166785 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression 8331 8337 8334 6908 8335 79685 8819 8341 8342 8347 8348 25942 8345 51742 8340 10284 64426 8338 1789 85236 1786 8349 3066 8370 5440 5441 4331 1022 2071 2966 2965 23378 3013 2068 3065 5434 5435 8932 255626 5437 2968 2967 404672 3021 3018 902 3017 3014 6839 474382 221830 29115 8970 7343 128312 25885 79595 9014 9015 94239 9013 55766 64425 7270 79101 8968 10849 11176 8467 30834 84172 51082 23411 653604 9533 54145 23309 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 96%425397 Transport of vitamins, nucleosides, and related molecules 51000 84912 7355 376497 389812 23568 3933 286256 55315 402 8884 9154 222962 51248 55343 10559 64078 347734 23443 3177 9153 2030 347 23169 291 11046 292 9197 293 10999 28965 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 96%9939291 Matriglycan biosynthesis on DAG1 120071 10329 10559 729920 2218 9215 113829 11041 79147 9486 1605 55624 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 96%202430 Translocation of ZAP-70 to Immunological synapse 3127 3126 920 3125 3123 3122 3120 3119 3932 3118 3115 7535 26191 3113 915 916 917 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 96%5660668 CLEC7A inflammasome pathway 5970 841 29108 3553 4790 10892 G2 PHASE%REACTOME DATABASE ID RELEASE 96%68911 G2 Phase 890 1869 1017 8900 1871 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding 9630 6000 55970 8787 8786 9628 54331 1460 1459 59345 1457 5082 2767 2769 22948 2793 2792 2791 2790 908 6950 2776 7203 2788 2787 2782 2786 10693 2785 10574 2784 10694 10576 2783 10681 10575 51764 94235 INHIBITION OF MEMBRANE REPAIR%REACTOME DATABASE ID RELEASE 96%9635644 Inhibition of membrane repair 9146 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 3084 6678 9542 10718 348 145957 10608 10413 51741 11033 6387 3925 6285 6714 1447 6868 5663 5664 9611 23118 55851 5241 83464 23385 51107 6776 2099 2670 685 2069 1839 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 8647 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 1029 1019 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-HSA-3301854.4 Nuclear Pore Complex (NPC) Disassembly 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 10762 891 348995 983 79902 57122 55746 9133 23279 79023 6396 140609 10783 91754 9883 129401 9688 23225 4927 23165 55706 TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166665 Terminal pathway of complement 731 729 732 727 733 735 1191 730 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells 1212 7074 2048 4318 1759 4067 5879 1213 1211 160 161 284656 102 7410 2045 2044 163 5663 2043 7525 5664 2042 1943 1942 55851 1949 83464 23385 1948 51107 1947 1969 1946 1945 10451 8218 1944 2051 2050 2049 2047 2046 285220 2041 2534 4313 1175 1173 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events 8331 23636 5903 9972 8337 9631 7175 440689 8334 11097 23511 8335 10155 8086 8021 1956 53371 4790 8480 140735 10762 8341 8342 8347 8348 8345 3688 8340 79902 10951 8338 85236 8349 1616 8370 9612 2146 8655 2002 3013 255626 2874 5371 3018 3017 348995 6907 57122 5931 8970 317772 128312 51143 92815 85235 55746 8969 221613 79718 8726 23279 8968 79023 6396 8841 1781 9611 653604 1780 1778 9883 129401 9688 23512 23225 5928 4927 23165 1783 55706 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 96%156588 Glucuronidation 7364 7367 7366 54600 54578 54577 54576 54575 7360 574537 54579 167127 10720 80146 54659 23169 11046 10941 133688 54490 79799 55347 54658 54657 7358 7363 7365 MASITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669924 Masitinib-resistant KIT mutants 3815 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle 8497 8499 10815 10497 9256 6844 6512 6616 6857 6804 6511 54407 22999 27165 8500 8541 57030 10550 6506 6505 5864 2744 6507 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 2677 2158 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-HSA-110320.3 Translesion Synthesis by POLH 55666 6119 7314 6118 5981 5429 5982 5983 7415 83932 25898 7353 5111 6233 7316 6117 5984 7311 5985 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%6787639 GDP-fucose biosynthesis 7264 8790 55343 2762 197258 282969 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation 4067 3055 2209 2268 2534 7525 2214 6850 2212 917 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism 3081 6898 3242 2954 2184 5053 883 259307 5860 5092 80150 MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling 1399 1398 23163 53916 382 2549 3082 5867 4233 LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling 5034 4547 1071 319 338 4018 MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation 81892 87178 2926 22868 6832 25996 9238 10128 60493 BIOSYNTHESIS OF MARESINS%REACTOME%R-HSA-9018682.3 Biosynthesis of maresins 2053 240 1571 1558 1559 1544 1565 1576 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation 79587 51067 55699 124454 23395 27068 57038 92935 5917 10352 54938 57505 3735 2617 9255 2058 7453 16 8565 5464 833 10056 4677 3035 6897 2193 7407 51520 1615 5859 4141 23438 57176 3376 25973 6301 55157 80222 7965 10667 9521 79731 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 96%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 5478 4507 5062 4001 375 5908 6888 3458 6648 9987 654483 27250 302 4478 1265 9446 5306 9049 6775 6627 3936 4282 5721 759 5055 6175 6950 5898 6647 1072 2939 3313 829 3181 998 3586 3185 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors 7022 10370 7020 5308 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 11116 7531 54930 5566 79959 5518 6790 93323 983 22981 5347 80254 55755 10806 22974 10121 9662 55835 10733 80321 55125 9814 115106 8655 79441 9702 5108 55142 10383 22897 10382 10142 5116 23332 80184 3320 22919 7846 5048 23354 8481 7840 11064 121441 22994 22995 7283 7277 55559 3161 203068 1454 8636 55722 4751 11258 1453 7532 54820 84131 9738 11190 4957 1781 95681 1778 1069 5577 9793 54801 10540 ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects 51529 7321 8881 64682 25906 11065 8697 7324 10393 29945 27338 119504 29882 246184 996 51434 51433 7027 1021 1019 595 1017 894 896 1871 898 1870 51343 6502 9134 1028 1027 1026 7029 1869 5925 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a 5373 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression 8452 8331 7004 8337 7003 8334 7005 8335 2353 10613 100128731 192670 27161 8341 8463 8342 8347 8348 8345 91445 6048 26523 8340 10987 53632 2354 91319 8338 4791 10956 85236 1499 8349 6185 23112 23476 6184 1019 57690 595 2932 192669 746 1603 2034 27248 8370 79139 2146 51009 4343 6400 3013 255626 84061 5562 5563 6772 5564 6774 5565 3021 3018 2033 3017 3014 80380 5571 7991 474382 201595 3703 8970 128312 27327 3716 83439 55766 1650 8726 8968 10331 7532 4780 3727 51176 653604 7415 1387 84661 11091 25937 9861 5133 8454 6233 23512 7316 5928 5929 10213 5706 467 5707 5708 5709 5700 5701 5702 5704 5705 4790 5682 5683 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 3725 5690 5691 5692 5693 5694 7311 5970 5695 9978 7314 6500 5687 5688 5689 4297 1460 1459 1457 4609 5931 8405 10413 3091 94239 9070 4613 11160 4751 29126 142678 51422 3659 54145 58505 6932 6934 58508 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 96%186797 Signaling by PDGF 1297 1293 1292 1291 6778 5921 1287 5155 5159 7057 80310 7059 5045 5156 7060 9564 6714 4893 6654 3265 5781 2889 1399 1398 5327 6696 5782 5340 6772 6774 7058 5335 8440 2886 1286 1285 256076 5295 4690 1284 5296 6777 1282 6776 5290 5291 1299 1298 131873 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation 2264 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654727 Negative regulation of FGFR2 signaling 5515 5516 5518 10253 8569 7311 7314 867 2254 2252 5781 2251 27006 8074 673 2249 2248 2247 2246 8823 6233 5594 7316 5595 2255 10818 8817 26281 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%419812 Calcitonin-like ligand receptors 796 133 797 79924 10266 799 10268 10267 3375 10203 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling 54518 7450 10125 3690 2243 7094 5908 11069 10411 5770 5747 9564 6714 6654 10235 207 1398 5170 2335 6464 2244 1445 2266 5906 6850 3674 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane 2157 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME%R-HSA-9629232.3 Defective Base Excision Repair Associated with NEIL3 55247 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 96%4720454 Defective ALG9 causes CDG-1l 79796 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME DATABASE ID RELEASE 96%9664323 FCGR3A-mediated IL10 synthesis 808 107 5567 108 10768 109 5568 3708 3709 5566 111 112 5335 113 114 115 2268 917 4067 3710 2209 5575 7525 5573 2214 2212 5577 3055 5336 5613 5576 2534 3586 196883 6850 PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-HSA-3215018.5 Processing and activation of SUMO 6613 205564 10055 10054 25950 6612 7341 59343 29843 7329 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 96%9793242 SUMOylation of nuclear envelope proteins 5905 7341 7329 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events 92421 1655 6382 27243 128866 2719 8678 221914 9672 23479 81631 79643 7405 85437 51652 7428 2239 5045 3339 29082 91782 25978 5289 2262 1514 7415 2817 30849 7113 8829 59272 26762 5925 6383 10082 6385 375790 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling 57580 10276 396 9138 4099 57142 4974 11214 128272 7531 4790 84894 26230 121512 29 5924 84904 4792 100271715 10018 25791 89846 54848 26084 22899 50649 8874 8997 64857 6453 7984 57449 389337 445328 3654 2245 5584 221472 8767 55701 9500 27018 4615 10672 23263 7311 9459 5970 5879 7314 3551 3066 4168 7189 6654 5663 27237 5664 6610 55851 83464 23385 51107 836 4803 4804 835 8878 3065 5599 7074 23421 26574 572 11108 55160 7410 6868 387 23365 23370 8841 9181 7409 1894 10451 6233 7316 9826 7204 9828 6655 23229 50650 9639 INTERLEUKIN-15 SIGNALING%REACTOME%R-HSA-8983432.5 Interleukin-15 signaling 3716 3601 3600 3718 3560 6654 6774 2885 6777 6776 3561 6464 9846 6655 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes 1351 1350 1349 5052 7001 1347 7531 1346 341947 54541 1345 192670 27161 2810 2821 54205 26523 7295 53632 2475 7296 23112 8626 5728 57690 125965 192669 7248 55004 4512 8649 4513 4514 27165 64121 57103 7249 58528 10542 7534 389541 10971 28956 7533 57521 10670 6009 153129 4343 10325 7529 2877 5562 5563 5564 5565 9377 84701 5571 613227 64223 10000 143686 2744 27327 83667 7157 1327 9167 7532 9997 4697 207 51422 208 1329 50484 1340 2539 1337 1339 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 96%380287 Centrosome maturation 11116 7531 54930 728642 984 5566 79959 5518 93323 983 22981 5347 80254 55755 10806 10121 85378 10426 9662 29922 27229 440145 55835 80097 114791 10733 27175 80321 653784 10844 55125 9814 115106 8655 79441 9702 5108 55142 10383 22897 10382 10142 5116 23332 80184 3320 22919 7846 5048 23354 8481 7840 11064 121441 22994 22995 7283 7277 55559 203068 1454 8636 55722 4751 11258 1453 7532 54820 84131 9738 11190 4957 1781 95681 1778 1069 5577 9793 54801 10540 SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers 8110 6601 8193 6603 26039 6602 6605 5977 8289 6760 55193 9274 60 9275 605 6604 86 53335 51412 196528 55274 57492 23506 64919 6595 65980 6597 29998 6599 6598 29117 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%212676 Dopamine Neurotransmitter Release Cycle 8497 8499 10815 10497 9256 8825 6844 6616 6857 6804 55327 22999 8573 8500 8541 6571 320 8224 5864 64130 6854 6853 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels 10242 3781 27094 3780 3778 3782 3779 3783 27345 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses 2892 2890 10211 2893 28988 26050 4916 22865 2319 2911 81858 2915 22871 23136 9066 57622 57502 79414 6812 9546 22839 11141 57669 58512 10611 10313 91683 94030 127833 57555 85358 9454 9455 347731 347730 6857 6804 9456 55327 22829 22941 50944 8495 8496 26037 8541 5792 26045 2904 57596 2037 2035 9229 2036 5789 26280 9369 54413 84189 341359 9378 8497 9379 8499 114798 57497 321 84631 78999 139065 80059 5802 8825 1740 143425 2906 8573 8500 2905 2903 2902 320 1742 1741 1739 64130 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717323 ceritinib-resistant ALK mutants 238 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013422 RHOBTB1 GTPase cycle 8452 6093 3183 11329 56254 5930 9318 10250 4646 7431 9475 23013 27316 9352 2873 79869 51138 10574 1627 10576 6434 9886 8654 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-HSA-2029480.3 Fcgamma receptor (FCGR) dependent phagocytosis 695 10552 10787 3984 8936 71 10768 5337 3708 51517 10152 3709 3326 3071 10163 63916 10006 1793 5879 4771 122618 23191 1398 9844 3055 1072 5594 5595 8398 998 5338 10093 10092 10095 5581 10094 10097 10096 3320 196051 23646 60 10810 84513 5335 5580 2268 7454 7456 5747 917 4067 147179 3710 4620 4650 2209 7410 4641 7525 2214 7409 2212 4651 5295 4690 5296 644150 5058 26999 5290 10451 25 5291 5336 4644 10458 10109 2534 8976 55845 4627 6850 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9615710 Late endosomal microautophagy 92421 55048 89853 27243 155382 128866 137492 93343 7251 51271 79720 3312 5116 79643 51652 3043 10226 7311 7314 29082 91782 25978 10013 1080 6233 200894 6035 7316 8100 123 1068 11315 51160 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447038 NrCAM interactions 8828 286 1742 1741 4897 1739 6900 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 96%192105 Synthesis of bile acids and bile salts 10998 114876 1582 5007 26031 9885 9023 8648 23600 114880 9971 114881 9420 10499 114883 1593 1581 1646 6718 1645 80270 11001 1109 3295 10005 10858 6256 570 51302 8309 8647 8644 DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) 10559 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 96%5576894 Phase 1 - inactivation of fast Na+ channels 30818 30819 30820 80333 3751 3750 3752 MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion 103 104 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9840309 Glycosphingolipid biosynthesis 6487 7368 2524 8869 30815 2523 9334 29906 9331 53947 9514 81849 64781 8705 8706 7357 84002 2583 6483 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 1137 1136 1135 1134 89832 8973 1143 1142 1141 1138 55584 APOPTOSIS%REACTOME%R-HSA-109581.6 Apoptosis 3002 355 5062 8743 4836 51074 841 23368 8737 329 54205 8795 7186 1613 1612 23604 8797 219699 9500 79792 90249 26060 51765 1499 331 4976 578 999 8428 22985 708 6304 10059 7027 8626 7159 115209 929 5588 581 353376 1687 148022 3146 8717 7161 5594 7029 1869 5595 7534 10971 7533 8655 7529 22900 57099 55075 56616 63967 6774 27113 23643 79658 3837 5533 5580 90427 10000 5747 7099 7532 207 208 9861 6233 1630 7316 10213 5534 5706 5707 5708 5709 6093 5700 5701 5702 5704 5705 4001 7531 5682 840 140735 5683 2620 118 7431 5684 4137 10018 28988 2810 5685 5339 356 5686 5717 5718 5719 11047 5713 5714 3009 7979 3008 5690 3007 5691 2339 3006 5692 660 3005 5693 5694 6709 7311 10134 5695 317 7314 3024 5687 5688 5689 1832 1830 100506658 9414 1829 1828 7082 836 5317 5366 1029 839 5599 324 2934 1677 1676 3148 596 598 572 842 7157 637 3836 8772 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer 7314 867 1956 4893 7039 6654 3265 5295 3320 5290 5335 6233 2549 374 7316 6464 685 1950 11140 255324 2069 7311 1839 SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions 2263 DARPP-32 EVENTS%REACTOME%R-HSA-180024.6 DARPP-32 events 808 5143 5144 5530 5532 5519 5567 5499 5568 5575 1020 5566 5515 5573 5516 5518 5577 5533 5576 84152 5534 5528 5141 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 96%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface 8547 5648 2219 2220 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%R-HSA-3323169.4 Defects in biotin (Btn) metabolism 5095 64087 56922 686 31 5096 3141 5091 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida 2683 11085 2515 7784 22917 5016 6677 8747 57829 7783 8748 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME%R-HSA-9958810.1 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) 1500 1499 1793 7314 5879 999 1520 6714 9855 7410 1508 7074 1514 50649 9844 3728 6233 1495 7316 998 7311 79872 1009 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) 22949 5743 4056 240 241 246 1559 3248 2948 2053 4048 1571 1558 239 1544 1565 1543 1576 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037629 Lewis blood group biosynthesis 6484 6487 124872 10690 2526 10402 2525 2524 30815 10317 2529 8707 2528 8708 8705 2527 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand 51284 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 8110 6601 8193 6603 26039 6602 6605 5977 8289 6760 9274 60 9275 605 6604 86 53335 51412 55274 57492 64919 6595 6597 6599 6598 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 96%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 1147 9447 9051 834 837 4790 351 83737 841 14 3326 329 7295 24145 3654 8767 4791 330 5970 3551 10454 7334 8517 7335 64127 7189 5608 64170 1540 257397 22861 7128 23118 1432 10392 6300 3656 5600 835 5603 10628 4210 3162 596 598 5027 58484 10910 842 29108 114548 6885 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 96%68882 Mitotic Anaphase 51529 7321 8881 64682 25906 11065 1104 8697 7324 10393 29945 27338 119504 29882 891 246184 7443 983 9798 996 51434 22933 51433 221496 200014 5347 2010 9700 260334 6683 347688 23141 23592 5520 7514 4001 113457 7280 10376 80086 51807 10381 10383 10382 112714 7846 84790 84617 347733 7277 7278 81027 79861 9883 129401 9688 23165 55706 92421 23636 9631 27243 128866 23511 53371 8815 79643 51652 29082 91782 25978 54908 6232 8655 25909 8379 9183 23047 1063 1062 9184 1060 991 151648 55166 1058 79019 151246 9735 23332 79003 55055 81565 22919 113130 348995 348235 3837 9126 5048 23421 57122 220134 57082 57405 147841 51143 6249 55746 4085 9133 64105 401541 23279 79023 10403 54820 80776 701 54821 6396 378708 5901 1781 23122 23244 1780 79172 1778 81930 10735 9861 55920 84643 6233 3796 7316 9793 91687 57551 79682 10213 5905 5706 1783 5501 5707 83540 5708 80152 5709 5903 2491 5519 5700 332 5701 55143 5702 27183 23063 5704 699 5705 11243 10274 5682 140735 5683 3619 5515 11004 5684 5516 5518 5685 9212 5686 25936 5717 8243 5718 11130 5719 64946 79980 11047 10726 5713 79902 5714 5885 5525 7979 5526 5690 55839 5691 5527 5692 5528 5693 5529 5694 7311 5695 7314 5687 5688 5689 7341 3930 7329 3842 9232 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 96%5627123 RHO GTPases activate PAKs 808 2017 4628 5879 79784 10398 4771 3984 5062 4629 5500 5058 2316 4660 998 103910 4627 4659 4637 5063 4638 RHOBTB3 ATPASE CYCLE%REACTOME%R-HSA-9706019.5 RHOBTB3 ATPase cycle 8452 7428 10489 22836 10226 9146 898 9367 51209 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 2249 2248 2247 2246 5335 2255 2254 2251 27006 26281 8074 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 96%1482798 Acyl chain remodeling of CL 3030 253558 5321 6901 8398 3032 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 96%1169410 Antiviral mechanism by IFN-stimulated genes 23636 9972 9631 7175 11097 23511 834 2635 8086 8021 4938 5229 53371 3608 8480 10762 7324 8678 4940 103 8638 201254 983 6059 7318 1965 8894 4869 1968 7334 11274 4734 5771 1974 1973 5595 9636 3304 23586 57506 6772 6774 317649 7706 348995 3837 3838 54920 3839 57122 5610 5611 2316 5300 55746 3716 23279 79023 2633 402569 3840 3841 6396 378708 5495 4690 5292 6233 7316 1660 3609 1982 5903 1147 5519 71 2634 5515 5516 2810 5518 9246 79902 2342 5525 2339 7311 7314 5045 3551 8517 5608 7341 1977 25820 115361 1981 7329 9775 3312 4600 51191 8672 2317 60 5335 201626 3306 3305 3661 8575 6895 199990 55120 3434 91442 6041 7157 57697 6622 9470 80233 4939 8877 9883 2175 129401 9688 2188 2187 23225 3836 2178 4927 4599 23165 115362 2176 2189 55706 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 96%71288 Creatine metabolism 6535 1152 1158 6538 2593 6534 2628 548596 6539 1160 ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%8939211 ESR-mediated signaling 8331 8337 8334 3276 8335 2353 192670 27161 8341 8342 8347 8348 8345 26523 8340 2354 8338 85236 8349 23112 6714 57690 595 340481 4893 192669 200845 858 4316 3265 55625 5481 8370 1027 5594 5595 4314 4343 3013 3065 255626 3021 3018 2033 3017 3320 3014 4318 9126 3480 3838 474382 8312 10000 8648 8970 5747 4435 128312 5536 27327 7514 10499 10498 55766 6387 857 8968 346562 3727 8204 207 208 653604 6801 1387 8503 10735 1386 5469 51523 4846 1105 2289 1509 23028 2288 4313 5451 8202 23030 7764 2771 808 1655 2770 7090 3169 9166 6908 9687 23189 2773 2494 7033 1956 7392 10274 7039 7391 7031 861 10728 865 1025 3326 8243 8850 2309 5885 2958 3725 2957 2100 2793 904 2792 2791 2790 2788 5241 2787 2786 2785 2099 5440 2784 5441 685 127933 2783 255324 51764 2069 7528 94235 2625 2002 1839 2963 2962 5434 55970 5435 5436 5437 5438 5439 5430 5431 5432 5433 54331 59345 6722 6667 4609 374 596 1903 1950 57678 94239 5590 5295 5296 2782 8877 5290 5170 54145 10681 4602 10524 P75NTR SIGNALS VIA NF-KB%REACTOME%R-HSA-193639.3 p75NTR signals via NF-kB 5970 4804 8878 7314 3551 4790 7189 4792 4803 6233 7316 3654 5584 8767 4615 7311 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 96%379398 Enzymatic degradation of Dopamine by monoamine oxidase 4128 1312 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects 1029 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 96%5626467 RHO GTPases activate IQGAPs 808 10788 1499 5879 8826 999 128239 1495 4221 998 6249 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression 891 5519 983 10776 84930 2029 55844 5515 5516 5518 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111448 Activation of NOXA and translocation to mitochondria 7157 7027 7029 1869 5366 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669934 Sunitinib-resistant KIT mutants 3815 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 96%8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 7022 1026 4609 7020 10765 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622323 Presynaptic nicotinic acetylcholine receptors 1137 1136 1146 1135 1134 1145 1144 8973 1143 1142 1141 1138 SIGNALING BY AXIN MUTANTS%REACTOME%R-HSA-4839735.5 Signaling by AXIN mutants 5519 1452 139285 2932 5515 324 5516 5518 8312 5525 5526 5527 5528 5529 CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948001 CASP4 inflammasome assembly 808 837 1992 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 96%3359473 Defective MMADHC causes MMAHCD 27249 25974 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 96%1638091 Heparan sulfate heparin (HS-GAG) metabolism 26035 6382 2719 64579 10855 9957 221914 9955 9672 64711 6448 9956 8509 222537 2239 266722 3425 2132 2131 3423 3340 3339 4669 2262 1514 9953 9951 2137 60495 2135 11046 9394 2817 9348 9653 90161 6383 10082 6385 375790 CYTOPROTECTION BY HMOX1%REACTOME%R-HSA-9707564.6 Cytoprotection by HMOX1 1351 1350 1349 1347 1346 341947 1345 25942 54205 125965 3163 4512 4513 4514 6256 213 5465 9612 5753 4363 2168 10628 6774 9377 96764 3043 84701 3162 3040 613227 571 6907 80205 8648 7975 10499 10498 79718 81502 6604 1327 9167 4780 4697 8841 9611 1329 644 645 1387 114548 55620 1340 23054 5469 85441 1337 1339 DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis 841 197259 8737 11035 7186 8717 8772 PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%1257604 PI3K AKT Signaling 1107 117145 192670 27161 90865 5155 26523 1108 2475 4233 5879 23112 5156 5728 9173 6714 57690 2932 192669 7189 79109 5781 6591 5880 146850 5594 5595 5978 2146 10818 4343 3065 55615 3815 3932 64223 57459 10000 27327 8726 23533 8841 207 208 5305 7409 8503 1386 23512 5928 23028 2534 6615 3630 2064 2308 11060 8975 81847 80243 23252 5987 8658 80351 2444 23186 2309 3725 3654 3164 2100 55004 8649 64121 7249 58528 10542 389541 28956 57521 685 10670 6009 255324 2069 153129 1839 84335 10325 6446 3084 5371 4303 572 842 7157 9965 2254 2252 2251 27006 8074 2249 2248 10014 2247 2246 7101 152831 8823 8660 23035 2264 1822 2255 84232 23239 9846 3667 6199 8817 8870 26281 7874 53615 23608 118788 5159 50852 4916 10273 4615 331 3066 51135 4734 1027 1026 2323 2322 57504 9112 2122 2931 54815 51564 6801 9861 6233 7316 3643 10213 5706 5707 5708 5709 1147 5519 5700 5701 5702 5704 5705 1956 7039 5682 5683 5515 5684 5516 8535 5518 5685 5686 8394 5717 5718 8395 5719 11047 5713 5714 5525 9219 7979 5526 5690 5691 5527 5692 5528 5693 5529 648 5694 7311 5695 6015 7314 5687 4193 5688 1912 1911 5689 8396 80012 84733 2099 6045 5468 930 23466 57332 4915 4908 9542 4909 1460 10718 627 1459 145957 1457 2549 374 5931 1950 1958 3082 253260 57761 23396 5294 5295 5296 5290 5170 5291 5293 57167 940 941 942 391 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 96%983705 B Cell Activation 5708 808 5709 695 5478 1147 5530 84433 5532 5700 10125 5701 6786 5702 5704 5705 10768 640 4790 3708 5682 3709 5683 4792 5684 4793 29760 5685 4794 118788 5686 973 5717 5718 974 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5970 5695 30011 7314 6500 3551 5687 5688 8517 5689 4893 5966 6654 8915 3265 933 27071 5777 930 7220 4067 3710 80228 7409 5295 4690 84876 9861 8454 5336 5293 6233 7316 5579 4772 10892 4773 10213 2534 25780 6885 5534 5706 2280 23291 6850 5707 4775 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA 8331 8337 8334 8335 192670 54487 27161 8341 8342 8347 8348 8345 26523 8340 8338 85236 144233 8349 57510 29102 23112 57690 192669 8370 5440 5441 201164 10526 3013 5434 5435 5436 255626 5437 5438 5439 5430 5431 5432 5433 3021 3018 3320 3017 3014 23405 474382 8575 7257 6895 8970 7247 128312 27327 94239 55766 8968 221400 122402 55124 84944 54456 5901 143689 11022 91646 54514 653604 4603 113802 8468 9271 56165 136991 283 54145 60528 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 7314 867 1956 4893 6654 3265 5295 3320 5290 5335 6233 2549 7316 6464 1950 11140 7311 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190242 FGFR1 ligand binding and activation 2254 2251 27006 8074 2249 2248 2247 2246 7049 2255 10755 26281 3730 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 96%69563 p53-Dependent G1 DNA Damage Response 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 4194 5695 7314 890 5687 25946 4193 5688 57060 64326 5689 1017 11200 51230 898 9134 1027 1026 1029 8900 472 7157 9861 6233 7316 10213 5706 5707 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis 3065 23112 79444 57690 192669 4308 192670 27161 5454 25942 26523 23405 596 597 3094 27327 4343 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 96%916853 Degradation of GABA 18 7915 STIMULI-SENSING CHANNELS%REACTOME DATABASE ID RELEASE 96%2672351 Stimuli-sensing channels 1185 65125 63982 1187 203859 1186 1184 1183 1182 1181 133308 1180 57101 11059 1179 150159 7439 51802 1193 22802 219931 2281 9635 338440 1188 444 10786 285175 65266 65268 6233 65267 10345 7316 285335 6717 144453 10110 808 55107 94015 6263 6262 23678 28962 5894 6261 55515 40 41 266675 54831 55129 50636 9311 161003 259232 7809 284525 196527 57719 1831 6340 7311 80727 7314 57578 121601 53373 6337 6339 6338 6446 7220 7442 7222 7224 7223 7226 7225 59341 79054 55283 23327 26133 54795 8989 55503 4308 162514 255231 57192 51393 80036 56302 57113 29850 2040 54822 140803 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 96%1839120 Signaling by FGFR1 amplification mutants PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling 344 345 84699 51360 9388 348 27329 338328 335 319 338 51129 9619 91289 5034 5045 4023 5046 5125 1071 116519 4018 8720 213 336 337 3931 4547 26291 55908 3990 64788 ANTIMICROBIAL PEPTIDES%REACTOME DATABASE ID RELEASE 96%6803157 Antimicrobial peptides 5657 820 7097 7096 51248 1991 4069 8993 6406 6279 6280 5320 728358 417 1671 1670 1668 5645 5646 1669 5068 80341 6278 6037 117159 130120 1113 4057 3347 3346 1191 3934 149954 55600 51297 140683 6039 245913 92747 245936 114770 245937 114771 245938 671 475 245939 338324 503618 613210 613211 6556 245930 503614 245932 1511 920 245911 245934 503841 84659 641517 117285 613209 400830 116842 1673 140850 128859 1672 10578 245927 245928 245929 245940 55894 57119 81623 100133267 57115 729230 140881 644414 5266 504180 122665 1235 538 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 96%4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 5519 139285 5515 5516 324 5518 1855 1455 10023 8312 7855 1857 5525 1856 5526 8321 5527 5528 5529 23401 89780 1499 857 1452 2932 4040 4041 7479 7478 7471 2535 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 96%111471 Apoptotic factor-mediated response 1029 331 578 317 842 708 22900 57099 55075 581 840 1687 56616 51074 836 54205 5594 5595 79792 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 96%174417 Telomere C-strand (Lagging Strand) Synthesis 54921 63922 7486 80169 5981 79075 5982 79991 5983 100134934 26277 25913 3978 5111 641 23649 6117 5422 5984 5985 5424 6119 5557 5425 5558 6118 54386 10714 2237 57804 7013 65057 7014 1763 SARS-COV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%9678108 SARS-CoV-1 Infection 92421 27243 4088 128866 4089 834 8678 83737 79643 81631 7405 51652 11035 6230 6231 6234 6235 6191 6193 6192 6194 4869 29082 6227 6229 91782 6228 2932 7187 25978 9641 7189 3921 7534 10971 5925 7533 6232 3656 64135 7529 23586 80143 821 57506 2033 7841 2197 7706 3837 2589 140032 54956 143 3838 2931 56965 83666 79668 84875 54625 10610 6483 6201 6482 6484 6487 6203 4245 6202 857 6480 51284 684 23193 256435 7532 10465 5479 27090 5589 6210 9868 29108 7415 114548 51065 6205 6204 6233 6207 7316 6206 6209 6208 6188 5094 5706 6187 2280 6223 6189 1655 6222 5478 6224 6218 6217 340061 7531 4790 861 4792 2810 7311 5970 7314 7341 1514 7113 6441 59272 3178 7329 85437 7428 29110 6667 3661 598 11123 1915 9111 5289 64398 9360 5170 26007 30849 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 96%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 857 7529 5170 7532 7534 7531 10971 7533 10000 207 208 2810 DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 96%4724325 Defective ALG8 causes CDG-1h 79053 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 96%72203 Processing of Capped Intron-Containing Pre-mRNA 81608 22938 5499 57794 5500 22826 22827 10262 54883 11325 10236 55749 23658 25804 27258 23524 10450 51690 57703 10465 11157 53938 57819 11193 24148 24144 8899 23020 55100 85313 143884 9879 9410 23398 3550 9092 9416 55234 10181 8559 58509 51340 6936 59286 5093 79576 5094 51691 51593 6434 151903 57461 10713 84844 55702 1655 5411 22916 153527 60625 27238 3183 84811 11017 4686 8175 84950 5930 9128 9129 51729 26017 7737 63932 9130 4236 79706 84081 25949 51503 27316 79171 55696 1659 10992 55094 79165 79869 26121 5725 163859 10523 10284 79753 7536 4670 51747 51634 51759 988 8189 11051 10978 6627 1479 6629 51692 220988 1478 1477 23283 23450 10914 53981 23451 51585 56949 5546 29894 55339 6638 10594 1977 5356 3178 3181 3188 3187 3185 3184 9716 22803 7884 3191 3190 51639 8896 3312 51645 64895 85437 154007 11066 8233 10081 10084 10179 10291 79622 55599 55954 8449 56339 57721 10283 9589 8241 23350 10286 10285 9343 56259 10946 10907 9360 27339 1665 84991 9883 129401 2521 9688 83443 23225 4927 23165 55706 23636 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 10898 22985 3192 4904 91603 348995 57122 55746 8106 23279 79023 6396 6233 7316 1660 5903 51428 79902 9584 6631 10929 7311 10772 6625 6626 7314 135295 64852 9785 10915 58517 6430 6432 27336 6431 55660 9984 5511 5514 10250 29107 22794 57187 51362 7919 199746 84324 84248 6427 6426 84321 5440 6429 5441 9939 6428 10212 728343 9877 51213 10189 84271 65109 23759 80145 2963 26097 2962 8563 8683 5434 5435 10482 9775 5436 5437 9295 5438 10921 5439 10569 11338 2733 55110 79228 5430 5431 4116 5432 7307 5433 4809 6632 6628 6634 6633 23517 6636 6635 6637 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037628 Rhesus blood group biosynthesis 6007 6006 DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 96%9734735 Defective ADA disrupts (deoxy)adenosine deamination 100 ICOS CO-STIMULATION%REACTOME%R-HSA-9927354.2 ICOS co-stimulation 5296 8503 5290 5291 146850 5293 23308 23533 5294 5295 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 96%2033519 Activated point mutants of FGFR2 2254 2252 2251 27006 8074 2249 2263 2248 2247 2246 8823 2255 8817 26281 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 96%9665251 Resistance of ERBB2 KD mutants to lapatinib 3320 55914 2064 11140 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%3769402 Deactivation of the beta-catenin transactivating complex 7090 7088 3065 9580 324 64321 6662 8945 83595 6657 6658 7089 7514 7311 6659 331 83439 1499 7314 7091 9070 607 90780 57680 56998 283149 4221 51176 207 25776 208 26108 55553 84661 1487 11091 6736 6233 7316 7534 5929 6932 6934 9757 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex 2963 22916 2962 2068 5434 5435 4686 5436 5437 6827 5438 5439 2968 2967 404672 5430 5431 5432 9150 5433 902 51497 25920 7936 7469 5440 5441 4331 1022 2071 6829 2966 2965 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT 3815 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72306 tRNA processing 23636 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 10898 113179 4234 8270 134637 79691 81605 54974 55644 55621 51002 9836 84267 81890 84520 91801 152992 57604 51605 54517 93587 115708 90353 63892 57570 221078 54482 348180 127253 129450 23536 1787 55253 24140 55039 60487 348995 54901 54802 54888 2058 54920 57122 83480 10785 54931 55746 9692 3028 23279 79023 6396 5901 55006 112858 5903 79902 10978 1478 79897 54913 29894 51095 11102 55687 64172 79693 25821 84705 51504 11260 1653 51367 10775 80746 10799 79042 10557 51493 10940 9883 339487 129401 79074 10556 283989 9688 283742 116461 60528 10248 23225 51637 4927 23165 55706 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs 246 239 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559580 Oxidative Stress Induced Senescence 8331 8337 8334 8335 2353 192670 8341 8535 8342 23043 8347 8348 8345 26523 7295 8340 3725 8338 648 4217 7311 4194 85236 8550 8349 6015 7314 23112 7027 1021 4193 1019 1912 57690 1911 192669 5608 1871 5609 9261 80012 1870 84733 6416 5601 1432 5602 5606 8370 6045 5594 7029 5595 1869 2146 1032 1031 23135 4343 1030 5600 1029 3013 7867 50488 9448 255626 23466 3456 5599 57332 3021 3018 3017 3014 474382 5931 8970 128312 27327 94239 55766 8726 7157 8968 653604 6233 23512 54145 7316 5928 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 96%418359 Reduction of cytosolic Ca++ levels 808 487 488 6547 489 6543 6717 490 491 492 493 6546 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 96%391906 Leukotriene receptors 57105 2840 10800 56413 1241 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 96%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 3105 567 821 64167 22863 8678 22872 51128 2923 3107 9871 3106 9632 10427 3134 6890 3133 6892 51752 6891 5289 6396 3135 10802 10484 30849 3309 811 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ 5826 55788 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME%R-HSA-5658034.4 HHAT G278V doesn't palmitoylate Hh-Np 3549 55733 6469 50846 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209952 Peptide hormone biosynthesis 3626 5443 3625 3624 3623 5122 94115 7252 3972 83729 2488 1081 DAP12 SIGNALING%REACTOME%R-HSA-2424491.4 DAP12 signaling 3824 695 567 5335 3932 3822 22914 5879 54209 3133 9402 4893 7410 6654 7305 3265 5295 5296 5290 10451 5291 5336 3937 2534 6850 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190375 FGFR2c ligand binding and activation 2249 2247 2246 8823 2254 2251 8817 26281 8074 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 96%194068 Bile acid and bile salt metabolism 6555 10599 6554 200931 123264 10998 80765 28234 114876 1582 5007 26031 9885 9023 8648 23600 114880 9971 114881 9420 10499 114883 1593 1581 1646 6718 1645 80270 11001 1109 3295 10005 6579 10858 6256 570 213 51302 8309 8647 2172 8714 8644 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 96%1912422 Pre-NOTCH Expression and Processing 8331 8337 5986 4242 8334 56983 10402 23509 8335 861 192670 27161 8341 8342 5870 8347 8348 4853 8345 4854 8850 4855 26523 8340 9794 3725 5584 8338 85236 4851 8349 5045 1991 23112 7027 57690 595 192669 10046 1871 10959 8370 7029 1869 4343 6400 3013 22938 84441 255626 100996717 51548 1999 100996763 388677 3955 3021 3018 2033 3017 3014 474382 8970 128312 27327 6484 2683 2648 6487 94239 55766 7157 8968 653604 487 488 1387 489 3516 54145 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade 808 3000 2979 2978 4836 2986 9397 2342 10988 388531 79823 2339 5145 5578 6010 2779 6295 5158 1259 5148 1258 5957 2792 5588 131890 2782 23173 5475 9626 6011 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle 5478 920 7518 1234 8815 3981 2237 7852 3978 3836 7520 3159 2547 11168 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME%R-HSA-162589.3 Reverse Transcription of HIV RNA 5478 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 96%3656225 Defective CHST6 causes MCDC1 176 4060 4166 5549 4969 4958 11081 2331 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 808 817 818 5923 5924 6197 6196 2904 4893 3265 88 1740 6195 2906 5170 4747 5594 2902 5595 1742 27330 1741 1739 815 816 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%1592230 Mitochondrial biogenesis 808 54205 6648 53632 56652 11232 5442 2551 23410 84808 23408 2746 23082 6256 1432 440574 2747 5465 27109 6742 79135 4508 4509 55902 498 3313 84303 6300 513 514 515 2101 10651 7978 516 517 5600 539 518 10476 10632 4580 9551 9556 25813 84833 10989 125988 5563 521 522 5564 139322 55735 5565 96764 8834 4899 506 54927 509 3418 5571 6907 80205 3054 8648 10891 64216 7019 51106 10499 10498 79718 6604 4208 133522 4209 64784 51422 8841 9611 9572 200186 1387 23373 23054 23409 1386 5469 814 85441 211 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 96%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) 283652 PI3K CASCADE%REACTOME DATABASE ID RELEASE 96%109704 PI3K Cascade 117145 2549 5140 9965 57761 5289 2254 2252 5781 2251 208 27006 8074 5295 2249 5296 2248 2247 2246 5290 152831 5170 8823 5291 8660 30849 2264 2255 2323 2322 54106 10818 9846 3667 8817 26281 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 96%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 55742 3688 3611 5829 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%192814 vRNA Synthesis 142 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME%R-HSA-5579032.4 Defective TBXAS1 causes GHDD 6916 NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling 3983 6586 6585 22885 4756 148738 6478 137970 6477 5335 57453 116986 5306 5747 7220 219699 56963 7222 90249 7224 7223 1793 5879 9353 7225 6091 8633 6714 9423 5588 5781 84448 4651 59277 4690 57113 1826 1630 7204 998 7430 8976 285704 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME%R-HSA-1362300.3 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 3065 7027 890 1875 1874 286826 132660 983 91750 7029 55957 1869 5928 5933 5934 4605 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-HSA-2470946.2 Cohesin Loading onto Chromatin 23383 23047 8243 10735 9126 23063 5885 10274 25836 23244 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions 5172 1811 6575 6508 9498 26266 6522 10568 6569 142680 57282 284129 57468 83697 6560 10723 10861 6557 6561 6559 6558 9990 115111 6521 57835 6574 6528 1836 6568 9497 65010 160728 8671 115019 23382 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events 727 718 1234 4852 6714 5594 3361 59340 2652 5443 5567 3355 5499 5568 1815 1814 111 1132 3354 112 113 3352 114 115 3351 1524 1129 6387 346562 5575 51083 7852 729230 1230 814 5577 10663 56670 5613 338398 719 5576 1237 1236 1235 5534 196883 1233 1232 2771 808 2770 4985 4987 5530 5956 5532 2781 2773 27198 107 27199 108 5726 109 2587 1020 351 4886 5733 4887 10850 4889 2359 1269 2357 1268 259289 259287 259286 259285 3579 4986 3577 4988 56477 5995 4543 5332 4544 259294 259293 259292 259290 259296 2793 259295 2792 353164 2791 5660 2790 6751 5540 6752 5539 2788 338442 2787 643 2786 6755 6754 301 8811 2785 2784 8843 5697 256933 2783 54429 51764 80835 94235 80834 10692 9934 5473 9630 8862 6000 55970 8787 4283 6346 5368 2550 8786 10563 6351 6352 6357 9628 5030 54331 6364 6363 53829 59345 6366 6360 1903 6373 26960 6372 2767 6374 6376 6370 134 5173 2769 5179 6750 150 140 151 152 58191 8698 2919 10645 2918 2917 2776 2916 2914 53637 2913 5582 2782 2912 2921 2920 221391 2778 8484 11251 23596 186 187 83756 10681 165140 50831 50833 9568 50832 2826 50835 50834 50837 50836 50839 2774 50838 2833 84254 2832 2831 431704 50840 1880 57007 283869 6003 2841 6004 2853 2852 10803 50865 5196 2861 64805 1902 9283 9290 6010 9294 10874 2779 1325 3627 6288 64407 2358 846 5996 5998 5999 183 623 624 10287 56923 8490 23566 353299 57121 5533 5580 5321 3838 156 5137 2840 5153 5136 6753 3827 129521 5578 3710 5330 5331 2780 23236 5573 5367 10316 26575 9170 84539 815 816 817 818 5519 10768 3708 3709 5515 5566 5516 5518 2847 5528 3576 728 10636 26086 84152 85397 8601 51289 126006 5141 10022 5143 5144 117579 339403 6001 6002 9560 26166 611 29899 63940 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription 1655 85437 7428 5925 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 96%3296469 Defects in cobalamin (B12) metabolism 8029 4548 326625 6948 27249 25974 55788 2694 51293 5826 4552 81693 4594 166785 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%8937144 Aryl hydrocarbon receptor signalling 9915 3326 57491 196 405 10728 9049 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%376172 DSCAM interactions 1826 57453 1630 9423 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME%R-HSA-9956520.1 ASS1 variants cause citrullinemia 445 57407 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions 6578 10599 353189 28231 53919 551 11309 6567 28234 6579 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 96%445144 Signal transduction by L1 3678 5879 3690 5604 5605 1956 7410 5058 3897 1460 3688 1459 5594 1457 5595 8829 3685 3680 4684 3674 FIBRIN FORMATION%REACTOME DATABASE ID RELEASE 96%9769733 Fibrin formation 5624 3690 2147 2243 2165 5270 2162 5104 3053 2244 2266 462 3674 HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis 5099 4312 55619 388 5267 350 1088 94121 8407 29127 11069 10411 6915 12 14 5155 1 51097 23052 9749 135228 2768 54495 813 5175 7114 3671 66005 7441 6814 10672 440533 914 6813 5670 7123 29106 5671 83706 5879 5672 5673 10184 6401 51571 4843 967 90952 5675 9564 5874 140885 4973 3699 5669 7273 5680 54863 2 8832 81 5768 29802 5781 23428 1084 7044 139818 5676 22915 10490 6402 91768 5678 29789 6404 213 7465 197 51368 1525 5552 2734 3543 22927 83953 2162 1072 120425 146850 2277 4267 7066 2995 4352 2994 962 10916 6403 2993 965 998 7078 5777 7873 54210 3273 55423 9056 1521 83692 9057 6414 51744 57572 308 6520 3700 5340 4072 5341 5345 5567 8140 3959 54676 23657 5568 1893 56301 259215 78991 6678 9948 6694 5025 11136 7424 3021 5004 7423 334 5919 55664 3932 374354 10447 5005 2268 5027 8968 11311 23533 346562 23348 5575 2886 7525 207 7409 88 653604 8503 5577 5336 6383 2534 10082 1445 6385 6850 2771 2770 6382 2773 221914 23414 9672 23186 2239 960 3778 3779 3635 10362 51317 3339 3705 2262 3683 2817 3674 3676 3678 9630 928 6566 2719 9463 682 4778 5051 2767 7102 2769 7277 7157 2776 5582 81704 375790 7010 284 55669 5197 7056 2165 2160 25942 9927 5270 5104 10544 6609 85440 57126 7040 226 7422 285 2888 51378 3066 64145 2621 10461 3309 5627 9046 948 8793 203859 5578 5593 5054 4282 5055 4097 5573 22920 6647 5579 23468 2811 8165 9371 196527 7804 7057 5023 5024 9127 5026 22953 3797 2625 2624 5152 10335 2623 2626 11127 634 7222 7225 23539 50848 9123 5590 387 57113 5890 2335 4602 3920 391 5889 5657 80005 3688 1048 1794 1793 6714 4893 5588 6654 9732 10235 3265 3684 5880 1432 1398 83700 961 3687 3689 5594 5595 7534 58494 6464 5906 5624 3442 3065 3441 11343 3440 3452 3451 3449 3448 3446 3445 3444 5770 3443 3043 2627 3481 3479 27154 5868 335 51266 302 2812 2316 3685 51706 5747 338 2815 2814 7975 857 7410 27094 10451 27345 5576 23028 10257 10487 8654 808 5216 5478 10242 10125 4099 5739 1020 2152 351 24137 5329 3897 87 285643 2793 2792 2791 5660 2790 2983 2982 161882 2788 2787 2786 2977 2785 2784 2783 51764 94235 5473 8515 55970 54331 59345 150 151 152 2782 11093 25 2778 10681 3672 3673 3675 3655 10019 5028 8795 5196 64805 3660 10603 8797 462 3512 9585 55083 23046 55605 113220 6810 1017 3833 3834 90990 23095 10749 830 55614 832 146909 55582 23303 51156 124602 64147 829 221458 7042 547 3053 3798 3799 7076 1062 2151 2149 2147 7043 139322 9002 5580 5321 5153 5136 3827 6546 4842 6547 3710 80228 481 482 483 1675 487 488 81930 489 84876 84643 4846 3796 3937 6717 27040 490 491 3717 2244 492 2266 64837 493 7414 26153 147700 54518 10112 5519 7450 3818 3690 2161 6786 9493 5894 6543 3831 2243 2155 3832 3708 3835 7094 3709 5908 972 5515 5566 56992 408 5265 89953 11004 5516 409 5518 2153 2159 2158 8858 5525 5526 5527 5528 5529 2157 10938 55604 221037 25970 11216 6281 3046 5271 3045 5269 5327 81928 5328 23764 3048 3047 6693 50808 23759 30846 30845 710 64780 140628 3456 7018 1191 5581 5583 9162 8527 26090 1795 8525 8526 57406 221955 5335 160851 1609 747 10846 1608 50940 1607 1606 1950 139189 4067 5138 3082 3659 5294 5295 5296 5290 5170 5291 80739 2207 4680 51206 10630 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME%R-HSA-4085011.4 Defective GNE causes sialuria, NK and IBM2 10020 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress 8331 8337 8334 8335 2353 192670 8341 81631 8342 8347 8348 8345 26523 653361 8340 2475 8338 1965 8894 85236 8349 5034 1968 23112 57690 2932 192669 64839 2034 213 8370 5753 2146 4343 3013 84699 255626 23657 3417 5563 6774 3021 3018 3017 3014 64223 8131 201163 474382 55846 23334 10000 440275 8970 144577 23677 128312 84219 27327 10641 81929 55364 55766 652968 96459 729438 8726 8968 79726 10985 154743 9681 57600 54468 11133 207 208 653604 7415 114548 23512 10963 5928 467 51726 118 10130 58477 6745 10897 10525 2081 153222 90993 64764 9797 4189 440 10106 1388 1663 148327 9709 6921 7466 3068 55062 6923 10954 1639 9695 30827 1054 116138 7709 56005 27230 81501 4512 4513 55033 4514 1200 2134 6734 2137 10488 64061 2135 11015 55666 10628 27102 22809 847 6888 84701 9532 7353 10294 7157 3484 7086 10013 9883 129401 9688 405 23225 4927 3159 5226 25828 23165 6818 55706 55860 23636 51164 9972 10671 9631 7175 11097 23511 93661 8086 8021 84516 53371 341947 8480 10762 25942 6230 6231 6234 9349 5584 6235 6191 6193 6192 6194 51121 7422 115209 6227 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 6130 6133 9612 6132 6135 6134 3309 6137 6136 811 6128 4363 6129 6142 6141 6144 6143 6146 6147 3304 6139 6138 6152 6155 6154 6157 6156 6159 6158 3320 2197 23521 4000 140032 2931 5611 6164 475 6166 6347 6165 493869 6168 140809 6201 79400 6167 4199 6203 10072 30001 6169 81502 6202 116832 4097 10061 6160 6161 257202 79594 1728 9588 2940 10935 27244 6175 26043 2950 9045 644 6210 645 6176 84181 6171 55620 6170 9451 6647 6173 51065 2729 6649 6205 9861 6204 8454 2730 8714 6207 6233 318 6206 7316 10540 2880 6209 2878 10213 6208 2876 10587 6188 5706 6187 2882 6223 9973 5707 538 343 6189 5708 6222 468 5709 6224 6181 6218 5700 6217 5701 5702 5704 5705 4790 5682 5683 5684 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 11331 5691 5692 7296 30968 5693 10730 5694 10121 7311 5970 5695 7314 6500 5687 5688 5689 5241 6256 5465 2099 6095 367 2908 4306 2877 100137049 472 672 3306 3305 6117 6119 79728 6118 1327 11258 1329 22926 10111 1340 4361 1337 4683 10524 1339 545 1351 1350 1349 51529 7321 8881 1347 64682 25906 1346 11065 1345 8697 7324 10393 29945 5393 11340 27338 22894 119504 23016 29882 8570 246184 23404 5073 996 51010 54512 51434 51013 51433 56915 118460 3336 7322 125965 9261 6195 1432 5594 5595 6464 5600 2168 3329 7867 96764 113235 2033 3043 3397 23643 3162 613227 3040 571 6907 80205 335 51266 8648 338 10891 4862 10370 7514 7975 10499 10498 79718 84447 6604 4208 4209 8453 7099 167227 9575 4780 8204 64784 4697 8841 9611 23411 50507 9572 200186 1387 23373 23054 1386 5469 85441 406 10743 2289 10424 2938 2288 5052 7001 4001 7531 10728 3326 6648 2309 3725 2673 4851 9978 55004 23410 8649 64121 58528 10542 389541 28956 57521 64344 10670 6009 153129 84335 8878 37 10325 3312 51360 6667 4800 4801 4802 7323 8720 8452 126374 112399 112398 8994 55662 54205 54583 7027 1021 1019 3552 1017 1871 898 1870 51343 830 6502 832 9134 1027 1026 7029 1670 829 3313 1869 5925 6232 8655 9812 27429 55466 9377 3301 4899 23645 9361 348995 5580 1649 57122 51143 55746 84962 83667 23279 79023 9167 7184 6396 10808 3281 1781 27000 26353 1780 259217 1410 3297 1778 116835 7266 51182 573 2539 3337 6767 51501 57805 2887 9531 22824 6782 1783 815 9530 816 3310 6737 817 91582 818 9529 5903 10049 3308 79094 139285 7094 140735 6197 6196 8535 8091 23043 26277 22872 79813 25913 7290 7295 3490 79902 57634 3009 5526 3008 3007 3006 3005 648 4217 4194 8550 6015 3024 25842 890 4193 1912 1911 245972 10919 5608 245973 54386 5609 3163 80012 155066 84733 6416 9114 5601 51606 5602 10113 9550 5606 2077 8290 9820 23523 9570 27287 523 6045 9429 525 7013 65057 526 527 7014 528 5598 1032 529 1031 9817 8992 23135 1030 90423 1029 3569 127124 2114 2113 51382 50488 533 9448 534 23466 3456 3576 5599 8900 10312 29855 1051 57332 7428 9296 1460 1459 1457 4609 374 5931 55738 596 5154 1950 598 3091 94239 1915 25994 2056 768 57761 1536 54145 1535 4688 4689 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 96%3359475 Defective MMAA causes MMA, cblA type 4594 166785 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646303.4 Evasion of Oncogene Induced Senescence Due to p14ARF Defects 1029 DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection 8331 8337 440689 8334 721 8335 9382 100128731 8678 4836 8341 81631 8342 8347 8348 8345 8340 2475 8338 85236 1499 8349 5034 6185 160 6184 161 163 746 79109 1603 81608 8370 10965 1175 1173 3013 22938 64135 3069 55615 5824 255626 10421 84061 57506 22863 285755 57794 317649 22826 3018 22827 3017 7706 4318 23643 6993 4691 11100 7991 10262 64223 54883 90701 201595 335 11325 10236 3703 55749 8970 64225 128312 8974 7514 23524 54431 1650 10450 54464 57703 8968 689 7099 54463 53938 28972 26986 5033 24148 653604 7415 23020 85313 9879 9410 9416 10181 9685 51340 23478 6383 5093 10082 5094 6385 51593 6886 57461 84844 1655 22916 1982 6382 1993 27238 3183 4686 8175 283208 51726 51729 6773 7431 221914 9672 80273 51503 27316 23601 55696 3326 10992 2239 10525 79869 10527 5725 10523 4670 4666 8813 988 8818 8189 11051 10978 6627 1479 6629 5045 51692 3339 220988 1478 1477 23283 23450 10914 53981 23451 51585 56949 5546 29894 55339 6638 2262 10594 1977 54344 550 1981 2817 5356 26762 3178 57521 3181 3188 3187 3185 3184 55666 9716 10313 3191 2719 3190 51639 8896 3312 51645 6238 8672 9532 7353 10084 10291 9789 10294 8449 2923 10283 8241 25777 23350 10286 10285 22937 9343 56259 10945 10946 5289 10949 10907 29959 60559 1654 27339 1665 84991 2521 83443 30849 3836 375790 10015 8737 23168 79577 7318 7317 80349 10533 10898 123169 9646 929 54623 9641 7301 2621 558 1616 4360 22924 3921 440400 9076 4061 1974 51234 1973 10461 945 3309 5627 811 91937 11314 3192 6141 3304 821 2147 4904 55236 3320 3837 3838 3839 5611 317772 92815 85235 8106 8969 5593 221613 402569 3840 3841 4153 712 6233 716 7316 57551 23352 1660 815 816 115004 817 818 340061 7251 4792 4793 2194 7311 7314 9785 6430 6432 6431 10250 7341 51362 199746 7082 55763 6427 6426 1994 5440 6429 5441 8729 6428 10189 7329 9039 2963 2962 8683 5434 5435 9775 5436 5437 9295 5438 10921 5439 79876 11338 5430 1191 5431 5432 7307 722 5433 725 4067 4751 253260 6632 5295 6628 6634 30835 6633 6636 6635 58505 6637 7448 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%389661 Glyoxylate metabolism and glycine degradation 4967 9380 1610 8528 92259 275 54363 2806 1738 2653 58510 8659 5827 189 64902 112817 27232 2731 1743 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 96%9834899 Specification of the neural plate border 89780 7545 83439 1499 652 4487 5081 1749 2249 7022 7021 6657 5460 2637 5077 4602 7020 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447043 Neurofascin interactions 1272 286 6386 1641 8506 4897 23114 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 96%5579015 Defective CYP26B1 causes RHFCA 56603 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME%R-HSA-9735763.2 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine 4860 MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%1632852 Macroautophagy 92421 65018 27243 128866 7332 8678 5071 79643 81631 7405 55669 51652 9927 53632 2475 10533 7322 29082 7334 91782 7335 25978 11345 8408 2034 10133 11337 8655 5562 5563 22863 5564 5565 3320 10226 5571 64223 51143 51001 1781 9868 1780 7415 8897 1778 3297 6233 7316 1783 140735 64419 7417 7416 7311 7419 7314 55062 7248 55004 8649 64121 7249 58528 10542 389541 8100 28956 115201 57521 55054 10670 89849 6009 285973 56270 153129 55626 9776 23710 8878 84971 10325 440738 9821 60673 54543 11152 84938 9804 83734 64422 23192 472 26100 3312 5116 1460 10452 1459 29110 1457 100188893 7323 401505 56993 5289 51422 10013 9140 9474 1080 200894 30849 84749 84557 139341 123 4077 1068 5830 79065 11315 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 96%8849932 Synaptic adhesion-like molecules 2892 2890 57497 10313 78999 10211 2893 5802 2906 5792 2905 2904 2903 2319 2902 1742 5789 57622 1741 79414 1739 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-9759785.2 Diseases of propionyl-CoA catabolism 4594 166785 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress 808 2324 1147 5519 3690 84290 107 108 109 7094 4790 4792 5515 5566 5518 3688 824 826 24145 5029 5175 2475 5970 1499 3551 2793 8517 2792 2791 2790 9641 1003 79109 3791 2788 2787 2786 2785 2784 2783 51764 4323 94235 3678 55970 55615 5567 10266 5568 6772 5770 111 133 54331 112 113 114 59345 115 64223 5520 9780 302 3685 10413 5747 2767 59341 5586 253260 5575 207 5573 2776 5296 2782 5290 5170 5577 25 5291 2778 5293 4846 5576 2534 10681 196883 7414 10203 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology 808 9070 3065 79718 2874 8841 5566 9611 84661 11091 25942 8085 814 9612 6907 5929 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-HSA-450321.4 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 10454 7334 8517 7335 5599 7189 64127 257397 5609 23118 6416 5601 5602 10392 3654 6885 3656 8767 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 96%196757 Metabolism of folate and pterines 81034 10797 10840 2350 25902 6470 1719 160428 113235 200895 441024 4522 4524 6472 10588 6573 DEATH RECEPTOR SIGNALING%REACTOME%R-HSA-73887.7 Death Receptor Signaling 57580 355 10276 396 7132 9138 7321 11214 128272 26230 7332 29 121512 5924 8743 84904 100271715 25791 89846 841 54848 26084 8737 22899 329 50649 8874 64857 8997 6453 8795 7984 57449 7186 389337 445328 2245 221472 5584 10273 8767 8797 55701 9500 4615 10672 23263 9459 330 331 5879 7322 9099 27005 10454 220213 7185 56957 7375 3066 4168 9641 7189 6654 55072 5663 8408 27237 81858 5664 1540 257397 8717 9261 9825 10133 55851 7128 23118 83464 23385 51107 4803 3065 10616 23421 8793 7410 8841 7409 10451 6233 7316 6885 6655 9530 1147 4099 57142 4974 7531 4790 84894 4792 10018 356 3654 27018 7311 5970 7314 3551 8517 84888 25999 90268 8837 6610 8887 55512 8439 56928 836 10399 4804 835 8878 5599 843 7074 29110 7323 26574 572 11108 55160 6868 387 142678 23365 23370 9181 1894 9826 7204 9828 23229 7124 50650 8772 9639 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX 2159 2158 2157 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450385.3 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 54464 7529 167227 55802 207 9261 5393 11340 22894 23016 23404 51010 54512 51013 56915 677 118460 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 96%9616333 Defective Base Excision Repair Associated with NTHL1 4913 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%8948747 Regulation of PTEN localization 331 4734 7314 7874 5728 6233 7316 5371 7311 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex 2963 22916 2962 2068 5434 5435 4686 5436 5437 6827 5438 5439 2968 2967 404672 5430 5431 5432 9150 5433 902 51497 25920 7936 7469 5440 5441 4331 1022 2071 6829 2966 2965 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) 24 157506 121214 5959 8608 145226 51109 6121 7276 285440 64220 5950 9227 4647 5949 6017 50700 3292 5947 8630 10170 6010 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 96%9761174 Formation of intermediate mesoderm 130497 2247 2296 2303 652 7849 3975 5076 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 96%380270 Recruitment of mitotic centrosome proteins and complexes 11116 7531 54930 728642 984 5566 79959 5518 93323 983 22981 5347 80254 55755 10806 10121 85378 10426 9662 29922 27229 440145 55835 80097 114791 10733 27175 80321 653784 10844 55125 9814 115106 8655 79441 9702 5108 55142 10383 22897 10382 10142 5116 23332 80184 3320 22919 7846 5048 23354 8481 7840 11064 121441 22994 22995 7283 7277 55559 203068 1454 8636 55722 4751 11258 1453 7532 54820 84131 9738 11190 4957 1781 95681 1778 1069 5577 9793 54801 10540 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%R-HSA-3642279.3 TGFBR2 MSI Frameshift Mutants in Cancer 7048 7040 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 96%111458 Formation of apoptosome 331 317 842 54205 5594 22900 5595 57099 55075 56616 51074 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway 5155 983 4233 5156 6714 4893 5588 6654 3265 115727 5781 3562 673 3559 3558 4140 25759 5594 5595 6300 6464 5979 10818 5906 53358 5900 7529 5604 3815 5605 5500 51125 5747 5536 3716 51114 88 1740 2906 4747 2902 2534 25780 1445 808 10125 3718 2064 7297 2342 3561 2339 6708 6709 9978 10434 51332 6711 6710 8649 6712 9986 377630 81926 58489 51104 28956 80824 685 255324 4684 2069 3674 1839 57731 10048 3084 402 9965 1852 2254 152559 2252 1850 2251 11221 5774 27006 1844 8074 2249 1843 2248 1847 2247 2246 152831 8823 8660 2264 2255 1742 3667 1741 1739 8817 23179 26281 8682 8452 9462 221002 4763 7010 64926 284 84078 8831 5863 399473 22808 10156 161742 9693 3570 200734 22821 54756 5923 2676 153090 8036 5924 2675 8437 84292 57139 5921 5922 5623 5159 64096 5786 4902 2323 2322 9048 5778 1849 1848 1846 5593 3845 3563 3560 1437 1439 1438 3568 3567 9861 6233 4296 7316 8315 5245 3717 10213 2244 5706 2266 815 5501 7414 5707 816 8844 5708 817 10256 5709 818 54518 8826 22866 5519 7450 5700 5701 3690 5702 5894 5037 5704 5705 2243 1956 7039 7094 5682 5908 369 5683 283455 5515 408 5684 5516 409 5518 5685 5686 5717 5718 5719 11047 5713 5714 5525 7979 5526 5690 5691 5527 5692 5528 5693 5529 5694 23463 7311 5695 7314 5687 5688 5689 3569 2668 10817 9542 2674 10718 145957 2904 374 1950 598 3082 5295 5296 5290 5291 5147 2335 KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway 8452 81631 5584 2932 64839 6502 1026 4363 23657 5563 3417 2033 3162 5580 571 10000 6347 140809 4199 7975 10072 83667 4097 10061 79594 1728 4780 2940 27244 207 26043 208 7415 84181 1387 9451 2729 9861 6649 2730 8454 2539 6233 8714 7316 2938 10213 5706 5707 6737 5708 468 5709 5700 5701 5702 5052 5704 139285 5705 4790 5682 5683 5684 5685 5686 5717 5718 5719 8945 7295 11047 5713 5714 7979 5690 5691 7296 5692 5693 5694 7311 5970 4851 5695 9978 7314 6500 5687 5688 5689 9429 9817 1029 55666 8878 672 6888 7353 1460 1459 1457 6667 4609 374 596 5154 1950 598 79728 7086 5226 REUPTAKE OF GABA%REACTOME DATABASE ID RELEASE 96%888593 Reuptake of GABA 6538 6529 6540 6539 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 96%5579020 Defective SLC35D1 causes SCHBCKD 23169 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle 9341 6093 396 55968 157769 397 398 5062 7879 55075 10298 9475 7037 81839 3932 1627 399 857 4548 1629 253959 55004 56924 7415 2631 6510 5058 55717 9497 2040 3728 9528 10376 7535 1445 114885 57144 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 96%9839406 TGFBR3 regulates activin signaling 3624 3623 7049 92 PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-HSA-212300.4 PRC2 methylates histones and DNA 8331 3013 8337 8334 8335 255626 121536 8341 3021 3018 8342 3017 8347 3014 8348 8345 8340 474382 5931 8970 128312 8338 1789 85236 1788 8349 94239 1786 55766 8726 8968 653604 8370 22823 2145 23512 54145 340602 5252 5928 2146 26147 3720 100170841 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 21 RAB GERANYLGERANYLATION%REACTOME DATABASE ID RELEASE 96%8873719 RAB geranylgeranylation 10966 7879 51560 57799 5861 51209 5865 5870 376267 55647 25837 84932 1121 11021 9367 23682 9363 8934 339122 11031 51762 116442 5874 83452 115273 23011 10981 81876 338382 142684 9230 22931 9545 54734 5867 9609 326624 201475 1122 83871 57111 401258 347517 5873 8766 8073 5875 5878 5868 5876 5869 27314 5864 10890 5872 51715 53916 53917 51552 5862 57403 401409 4218 115827 64284 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells 861 865 3958 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 96%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 7874 55284 7321 55236 11065 7332 7324 27338 7320 8078 7347 7317 7319 7311 3093 7314 7322 29089 997 92912 10477 90268 7327 8239 7326 7328 54926 65264 6233 7316 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 96%5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 7474 1213 1211 160 161 163 1212 2535 7855 4919 1175 4920 1173 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 96%9845619 Enhanced cleavage of VWF variant by ADAMTS13 11093 7450 RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-611105.8 Respiratory electron transport 54539 1351 91942 90871 1350 3052 79751 1349 29078 83733 100131801 8402 8604 137682 1347 192286 10165 1346 4190 341947 4722 4191 2109 4705 2806 1345 4707 2805 4708 3954 4709 4700 4701 4702 4704 6341 4698 79064 54205 4716 493753 4717 4718 4719 51079 4710 4711 4712 4713 4715 125965 51295 3313 9377 613227 9167 4697 5018 4512 4513 4514 7385 28976 7384 4728 7386 4729 440957 4720 7388 4723 440567 2395 4725 4726 7381 25915 728568 55572 55245 4731 29090 10975 152100 57128 93058 4519 27089 100996939 29796 116228 90624 28958 84300 55101 617 150274 51300 1353 84701 54902 374291 790955 1537 6389 90639 55471 80775 10063 4706 2110 119559 6391 6390 6392 4540 2108 4541 4535 51204 4536 285521 4537 6834 4538 25994 84233 80219 1327 25880 80224 51103 389203 284184 4714 4694 9997 4695 4696 1329 79133 57226 51241 126328 1340 10131 55967 1337 55969 84987 1355 100303755 1339 55744 55863 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 5708 2324 59 5709 23462 5700 4088 10460 5701 5702 5704 5705 5682 5683 5684 5685 3280 5686 4853 5717 5718 5719 8850 4855 11047 5713 5714 9794 7979 5690 5691 5692 5693 5694 7311 4851 5695 9978 7314 6500 5687 5688 5689 5663 10046 5664 388585 55851 83464 23385 51107 7534 22938 84441 2033 2648 182 102 54567 207 23493 1387 9861 3516 8454 6233 7316 10213 5706 5707 METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 96%9638482 Metal ion assimilation from the host 3043 3040 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%211945 Phase I - Functionalization of compounds 2326 26 216 66002 6916 5740 1582 23491 10858 1594 124 125 1584 51302 84532 126 5447 127 128 217 55902 219 130 131 196743 1066 4051 11283 5443 126410 1580 1592 57834 284541 56603 340665 285440 1589 1585 8648 9049 10499 4129 1591 4128 1727 1579 1545 113612 8529 5742 9915 134147 670 218 10728 2052 314 1572 8639 13 3326 1571 64816 874 57491 196 1558 4835 1557 1577 54996 1555 64757 1544 1565 1543 1576 1553 29785 1562 1573 1551 54905 2328 1549 2327 1548 1559 80777 6256 120227 1588 112812 2232 2230 1583 9971 9420 1593 1581 1595 8824 405 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 5888 1876 80314 672 11335 79813 5932 5931 23269 7703 648 6015 317 8317 8726 7027 8409 6241 83746 10138 1911 10919 80012 1111 4149 23429 6045 23512 7029 1869 5928 2146 23468 84108 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis 122961 112812 150274 2232 2230 51218 81894 51312 2395 81689 57128 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 96%1482801 Acyl chain remodelling of PS 10162 114879 123745 114882 255189 5319 22925 51365 64600 100137049 254531 8399 30814 5320 154141 5322 5321 26279 283748 81579 114884 11145 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-HSA-1660661.12 Sphingolipid de novo biosynthesis 5587 8560 123099 259230 124976 79603 94101 10558 55304 10715 151742 1455 2531 5007 91012 23683 94103 25865 9217 80777 142891 29956 388931 166929 165679 8877 79152 9517 9218 9429 204219 253782 171546 29095 4363 56848 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development 808 3065 79718 25942 814 9612 6907 2874 8841 5566 9611 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins 8331 8337 8334 8335 100128731 8341 8342 56910 8347 8348 8345 91445 6048 8340 10987 8338 4791 10956 85236 8349 6185 6184 746 1603 2034 8370 79139 51009 6400 3013 154 255626 84061 6774 3021 3018 3017 3014 7991 474382 201595 3703 8970 128312 8314 1650 51035 8968 10331 7518 653604 7415 11091 23512 5929 6881 9100 79694 64426 6921 6923 729238 908 113457 90268 6950 7203 7280 26272 6905 9986 83752 26234 377630 10693 6468 10574 10376 10694 6902 23438 10576 57176 25973 2629 55157 10575 80086 80222 10667 26190 6904 79731 79587 26270 6903 51067 55699 9630 124454 51807 6000 23395 27068 22803 8787 57038 92935 7411 10381 10352 10383 54938 57505 8786 10382 2617 55294 112714 55135 2934 402 6440 9628 7846 60 84790 10471 5201 5202 6499 5082 84617 11328 10238 2767 26330 10517 1155 347733 84261 2769 7277 7157 22948 7278 63971 26985 26224 81027 79861 54461 2776 10528 5203 5204 8877 10564 9883 129401 9688 292 293 23225 4927 23165 55706 23636 9972 9631 7175 11097 23511 8086 8021 53371 8480 10762 53918 6059 92305 6596 23168 6230 6231 9781 79577 6234 51322 9349 5195 6235 6191 80349 6439 5192 7040 5193 6193 5194 6192 5828 6194 4976 123169 51255 51121 9646 257218 115209 6227 55829 9810 6229 220441 6228 54623 11224 200916 6122 6124 6123 6125 25873 2621 140801 3921 4736 6130 6133 4061 6132 6135 6134 6137 5627 6136 811 6128 6129 25809 6142 23287 6141 254173 6144 25941 6143 6146 374969 60509 6147 79739 142 54839 158135 4248 821 25924 284076 6139 22846 6138 9654 6152 164395 6155 6154 123624 26140 6157 23093 6156 6159 83887 5873 23170 6158 79841 2197 91978 23521 84276 150465 79805 140032 340351 84871 5610 5611 6164 6166 6165 6168 6201 6167 6203 6169 6202 116832 6160 6161 5862 6175 9045 6210 6176 6171 6170 6173 51065 6205 6204 6207 6206 6209 6208 6188 6187 6223 6189 6222 6224 6181 6218 6217 199857 79868 8875 8876 57719 6670 3090 668 327 197257 29928 51142 9804 11338 26519 50 26520 1000 1431 10440 36 27034 3913 1080 84749 3915 2335 115827 11315 64284 161725 4978 22854 503542 3912 100287327 55593 27076 3105 148789 567 2350 10617 84920 8313 2109 93624 57799 10868 57559 10869 5865 143471 389362 376267 22818 5698 1043 5699 56984 80328 22820 51371 80227 83844 84932 5710 1048 10197 79589 122706 6975 5711 10600 8624 146183 5715 23326 5716 79931 84262 54872 5696 8934 9491 23198 10026 161357 5720 1087 5721 7322 100287178 29089 997 419 10454 4122 7334 23556 420 349667 7189 8733 432 433 55768 8724 284098 100287144 51520 11316 683 1615 5859 23770 6314 4141 91833 3033 80740 349633 100287364 9609 326624 3376 94005 79091 7965 53942 152330 9521 11070 5443 5624 5277 64135 5279 254013 3065 249 5283 130576 23586 251 1435 5917 84282 5281 57506 23275 401258 5067 3735 347517 93183 9255 8581 4286 7007 360226 11019 221143 7706 11014 2813 100287513 2058 27247 2822 5878 55288 5868 7252 401447 5869 80235 9487 9488 9486 1081 146760 7070 50863 51715 9276 84628 53916 53917 1315 1314 646627 113829 387787 80055 2653 84892 100287238 100287478 120071 728386 57403 57646 100287205 257194 100287441 2218 1368 2215 100288520 401409 144245 58530 22944 100287404 55031 10966 57695 284348 3183 154064 26958 25862 56254 79812 128869 390243 9318 54764 55611 51014 23423 7512 266727 51272 5329 4253 2873 55647 353091 51138 25837 137797 219333 78990 55650 51299 79609 84197 84196 9960 23627 64377 10318 170384 5045 4045 55432 10329 729920 7046 7048 116372 4062 115273 23172 51651 1975 9761 8434 372 1978 84101 1977 381 142684 9527 7369 1981 9545 392188 399818 171169 54965 196483 64772 10670 54732 51227 51226 8000 23358 54742 84132 145173 123904 80124 57188 2591 84720 143662 83871 79695 645836 10417 57111 118430 10942 147719 10418 170689 6844 29761 171019 83639 79147 54437 6804 645402 324 9510 129080 9037 51601 10568 4582 51604 6569 5199 84992 4583 84750 2517 7058 4584 151194 4585 8078 4586 728419 200958 8073 51128 114803 157869 4706 29954 727897 27314 56667 54516 29071 9617 9507 84340 4540 9871 80070 4541 9632 10585 4535 140766 4536 9508 10427 4537 9509 4538 10071 4539 94025 4597 339366 92399 221981 79875 81794 140453 55901 4588 4589 81792 55624 283463 8720 9719 56999 10802 56913 11093 394263 10484 11173 11096 11095 11174 9215 80731 170690 54507 170692 92949 170691 7332 5071 8737 84164 329 10973 51816 653509 5222 1755 221395 7186 5029 29080 8473 643834 9476 29995 643847 330 2922 4508 4509 498 3313 183 5096 539 10476 10632 2147 522 27429 506 9361 509 8451 7320 338557 8450 56852 1642 57599 51514 3827 2864 444 1743 4967 139285 2155 79697 89978 133686 1819 5566 83475 285362 64122 8535 23210 8460 1984 79642 2677 2159 55854 7295 2158 25870 3490 8858 8459 51611 4733 65094 340075 648 91433 23463 4194 79672 410 6015 412 79831 84864 5464 890 414 4193 415 1912 92715 1911 416 51389 285381 120526 22901 153642 80012 100137047 84733 347527 55239 56648 1725 1802 1801 6045 1361 1029 3569 8900 57332 374 55738 1938 1937 1936 1933 1917 1915 102 440689 721 718 4191 8678 248 354 3817 8893 1965 8894 8891 8892 1968 8890 1967 64326 3416 1891 10965 1154 2688 8835 11282 7841 51201 55741 11320 90701 4247 4249 10610 6483 6482 6484 6487 4245 4124 6480 25834 23193 256435 2530 27090 11253 5589 28972 9868 23478 3630 4512 4513 4514 6441 55666 4723 3190 4731 4057 7353 3419 3418 9789 5875 4303 5876 2923 3486 3484 10945 632 4695 60559 2271 8801 7874 23314 6790 25942 9189 4719 197370 493861 51079 9994 115426 4712 57591 7690 79677 56160 54780 10521 6672 6746 205564 6748 6304 6747 10055 6731 10054 6730 51602 6729 286053 3066 6726 25950 200845 6728 23137 6727 4152 23471 59343 29843 6294 7153 7155 7150 9612 8312 9656 10072 79594 51564 26043 7022 7021 23468 10155 7039 114907 7057 83746 2746 90850 22980 9147 23008 55139 9021 2625 2626 28996 2648 54471 7453 16 8565 1327 91574 123263 833 10056 4528 4677 219402 51250 6622 115416 3035 1329 6897 2193 7407 1107 260334 1121 347688 11021 9363 23062 4869 23163 9099 51762 5728 83452 4878 338382 9230 26088 27166 5867 3329 3481 3479 7703 84447 4221 51499 221656 8850 2488 7528 6696 5371 4287 348 7323 135 5179 94115 4086 4087 4088 4089 384 64750 4092 3972 9314 55176 29927 23480 8239 10952 86 830 832 829 7076 3624 3623 4052 9377 1643 9958 51377 9101 7270 59348 3622 2266 2243 408 409 4738 1356 7018 55832 25879 1629 1738 1294 135228 813 338328 255738 29106 5034 5874 116519 5768 22915 213 197 336 337 5340 6694 334 114785 3054 55252 55777 3607 7345 7347 221937 123228 171023 2683 3098 30815 11041 6383 124872 2804 10402 440138 10130 58477 6745 7466 3339 1639 9695 54995 5832 9334 8192 9331 10845 22921 4482 26503 5110 253827 6734 51734 11015 79369 2719 8703 8704 8702 93010 10678 2525 126119 92552 9929 27005 56957 7375 7187 9641 1540 7128 217 219 9112 10210 2589 1439 1438 8693 2590 55568 442117 374907 84002 11227 11226 374378 51809 64409 6996 84752 140687 9245 114805 2650 168391 192134 63917 117248 51146 146712 51301 26290 50614 57452 79623 10164 64432 65003 91689 64951 65005 6687 65008 28977 10939 90480 23203 51081 7284 6150 55168 221154 64949 28973 7417 65080 51642 5018 7416 10730 54998 10573 11222 7419 128308 51649 9553 64960 92259 63875 64963 64965 64968 55173 55052 64969 51373 26284 51650 60488 51253 51258 219927 29074 10102 56945 64975 28998 64976 79590 64979 64978 23107 28957 64928 7818 57129 51263 29088 51021 54534 51023 51264 652 51069 84545 85476 78988 122704 65993 64981 10240 64983 3396 26589 63931 6182 54460 6183 118487 51073 116540 740 124995 54148 116541 55037 29093 9801 10890 5872 51116 10884 54948 51318 51552 387 6472 146664 7879 4722 10652 3998 26286 6770 3895 6811 3371 2200 3952 79087 85365 29929 10195 79796 9526 56052 79053 1798 91869 2627 5372 5373 4351 29926 29925 21 23708 3670 3028 23032 8453 2107 26986 1605 2935 4313 140838 29906 207063 6675 81849 51046 5973 51005 22845 55808 6489 64841 5476 10020 256281 79644 10825 55577 7425 2673 10537 8813 55208 9945 197258 28952 23142 8818 7264 26094 338596 54939 8790 9655 23038 55343 140825 29880 10559 23369 84620 54951 23363 2762 54165 8869 5238 9306 149951 116150 55907 1161 8128 80344 55827 57171 282969 23113 84259 54187 56929 80896 79016 54344 51122 79947 54876 7903 50717 4758 83987 129807 150684 4759 8816 90864 59272 170622 10116 64344 29099 79269 51397 55884 55527 23412 8878 56995 28991 80067 123879 8883 122416 375 3312 1522 29104 27430 51504 150 152 5162 5163 8074 5160 1737 4200 154881 6478 6477 283807 1215 51088 9616 7317 462 7319 7045 9027 793 3093 10098 54959 7336 4069 1471 150726 325 9627 118424 9445 6653 23621 55336 340348 7327 3015 6406 7326 4240 7276 7328 81619 23555 54926 65264 93611 127247 401036 79791 1066 2028 3798 3799 51665 1395 51666 64924 57393 2999 3800 63891 619373 5122 142686 7941 4311 142685 55236 1363 290 51676 1360 142689 83729 1359 10159 1636 5972 3626 80204 3625 169026 1045 57542 5126 139760 1803 56605 23014 7019 25793 11275 89122 64410 222235 54850 140456 140458 140459 90135 25898 146330 140460 140461 140462 54620 115290 7704 55958 8139 390594 55284 84961 8924 122769 55175 27252 51130 26046 9903 377 9246 92369 126433 26259 201456 80028 144699 899 84861 92912 10477 26268 91851 90293 84727 92591 26263 26267 53339 10489 285231 89890 11167 9820 26235 26118 79176 26232 84085 4008 9817 51725 9039 26249 8065 140739 9040 79754 84541 80176 23194 7428 136371 10324 10970 1487 4312 90865 1789 1788 1786 55851 83464 23385 51107 5423 1511 136 84364 346562 114548 4644 8975 81847 23252 5987 57134 4121 8658 80351 10905 1632 23682 11031 116442 23011 10981 22931 54734 201475 1122 57104 10474 4905 211 2235 55860 51164 2890 10671 93661 84516 5080 8767 6288 11274 64127 10392 79155 9097 1453 9738 1069 9861 8454 6233 7316 10540 10213 6885 4218 5706 23291 5707 5708 23265 5709 5700 5701 5702 5704 5705 378 5682 60412 5683 4792 5684 54536 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 10121 10640 7311 5970 5695 11336 7314 6500 5687 149371 5688 8517 5689 8915 7341 7068 5241 7376 6256 7421 5465 55763 8554 2099 7181 6095 8729 367 4929 2908 51588 6612 9759 5468 55770 7329 6613 4306 2516 5914 10401 7486 672 8766 5111 79823 641 6117 79728 11258 580 8774 8775 7321 22796 9382 11065 51560 7324 10618 51209 27338 25839 5870 983 83548 63908 9146 57511 10466 8027 9367 1499 339122 10254 84342 91949 2033 335 8648 338 10891 10499 4780 8204 8841 1387 1509 1655 808 351 2801 993 6708 6709 9978 286 287 2793 288 2792 2791 2790 51332 6711 6710 6712 2788 2787 796 2786 2785 2784 2783 51764 94235 3375 57731 55970 54331 590 59345 43 2641 5864 2782 2695 7349 10681 8533 1604 64708 8452 8607 125476 84078 10980 93973 29844 54891 79913 50813 54617 10920 283899 83444 5886 1462 5887 4798 10445 7508 38 3485 3158 3483 2720 622 51246 411 54757 5019 8404 8542 3491 3489 3488 3487 64856 56652 10117 3816 1114 258 7857 10232 5954 898 56955 1758 4241 6502 3270 1616 265 9134 6742 401138 51156 1026 5069 1974 1973 147111 51280 8662 56975 8663 8661 60676 8666 3956 8667 4924 8664 3053 6232 8655 8665 26085 8614 27335 3646 2519 51386 375056 10272 7458 8668 174 8669 80341 10480 54972 4148 1964 3698 991 84141 29086 9210 11098 51720 54587 63967 84142 165918 7158 5893 9577 348995 79184 9736 9126 57122 10196 317772 51143 92815 55746 85235 8969 221613 8295 23279 79023 7184 6396 1781 1780 1778 10735 5905 1783 1512 5591 5903 332 55143 10274 140735 3619 79090 5265 6399 5861 23243 9212 22870 8243 2153 22872 2348 10175 5537 79902 1983 10972 5885 9554 9669 9117 80267 11196 10299 10206 64689 56886 126003 267 55291 7844 23256 1075 5617 55757 11236 58485 254263 25956 55014 81562 51693 2157 122553 8615 966 10342 27095 149111 9919 81876 83696 10959 10113 90411 10282 26984 9570 51399 89866 79748 7109 128637 10960 7385 4519 27089 2230 1460 1459 1457 4609 5931 3091 54145 58505 6301 6934 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 96%112308 Presynaptic depolarization and calcium channel opening 784 785 27092 773 774 777 55799 9254 781 782 783 10369 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives 5743 247 246 2877 2876 2879 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants 808 10256 817 54518 818 8826 22866 7529 7450 3690 5604 5894 5605 5037 2243 7094 5908 369 283455 408 409 3845 6714 4893 3265 673 4140 5594 4296 5595 8315 2335 5245 3717 2244 1445 2266 5906 7414 815 3674 8844 816 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9955693 NAGS variants cause NAGS deficiency 162417 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 96%5210891 Uptake and function of anthrax toxins 808 5045 5604 5605 10015 5609 6416 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 1616 546 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 96%3108232 SUMO E3 ligases SUMOylate target proteins 23636 9972 9631 7175 11097 23511 1107 8086 8021 23314 53371 8480 10762 6790 25942 7508 9189 197370 493861 9994 115426 57591 7690 4791 79677 1789 56160 1788 54780 1786 4869 10521 6672 6304 51602 286053 3066 9641 23137 4152 6294 7153 1616 7155 7150 8370 9612 9112 3065 142 10210 165918 4286 7158 5893 2033 348995 9126 57122 5610 8648 7703 10891 55746 10499 9656 23279 79023 7518 8204 6396 51564 59348 1387 7022 1069 10735 7021 3622 23512 6996 5905 23468 1655 5903 3183 332 55143 10155 8924 10274 3619 4792 8535 5987 9212 8243 79902 5885 648 5970 6015 4193 83746 1912 8517 1911 6670 3090 668 7341 80012 7068 84733 5241 7376 6256 7421 5465 8554 2099 7181 6095 6045 367 4929 2908 51588 6612 9759 5468 7329 1029 6613 4306 2516 5914 10401 7486 3190 5371 672 57332 7428 28996 5111 641 6117 7157 1487 9883 129401 9688 23225 4927 23165 11315 55706 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%75108 Activation of BID and translocation to mitochondria 841 3002 4836 637 SERINE METABOLISM%REACTOME DATABASE ID RELEASE 96%977347 Serine metabolism 10955 26227 63826 256987 347735 619189 5723 29968 57515 113675 10993 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%163765 ChREBP activates metabolic gene expression 10554 47 2194 51085 6945 31 32 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%8854691 Interleukin-20 family signaling 282618 3718 7297 3588 6772 6773 6774 29949 116379 53833 53832 55801 282617 11009 282616 50604 50616 6775 3716 5781 6777 6776 3717 58985 163702 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes 468 7975 5052 23657 1728 4780 2940 84181 2033 1387 3162 2729 6649 7295 571 2730 2938 7296 140809 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum 4851 4853 4854 56983 23509 4855 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%212165 Epigenetic regulation of gene expression 8331 8337 8334 1107 8335 8341 8342 8347 8348 8345 65251 1108 8340 162967 162963 8338 51129 1789 85236 1788 8349 1786 4023 2932 284306 51230 8370 7913 200424 29128 2146 84649 7403 3013 2167 3065 11343 255626 3991 6601 6603 6602 6605 23175 3021 3018 2033 3017 5346 3014 57693 6907 57459 474382 3054 7700 8648 8970 10891 128312 22976 51003 10499 55766 79718 6604 8726 8968 8467 9031 4221 8841 9611 23411 653604 1387 84661 23054 11091 5469 23512 5928 5929 29947 8202 147646 90853 6908 2494 79685 8819 1020 155054 8850 51742 147686 10284 64426 6940 30827 23451 80312 22823 7767 2145 340602 5252 26147 3720 54790 100170841 55422 6871 55683 55689 84911 57104 10793 8800 284058 729359 60481 1024 55617 7069 63924 91272 54934 60 10474 2180 1810 10179 51562 79862 26993 26009 9968 55596 29915 9969 259282 112869 57325 84148 23272 51105 7562 51535 22822 80335 57678 6319 9739 7576 5166 162655 25 10025 23309 7581 11168 9757 892 22880 53615 10001 1050 11335 25942 10445 197320 79611 8473 25799 29079 3066 86 9612 5925 9862 6595 57504 6597 90390 6599 9112 6598 948 8110 7695 8193 26039 55729 121536 5977 6760 8289 9274 6839 9275 605 9869 221830 29115 7343 25885 79595 54815 9014 9015 9013 64425 84962 7270 10514 79101 79447 10849 133522 11176 9422 30834 84172 84246 9443 8085 9442 9440 6996 23468 9439 10155 79813 2074 9219 9477 9188 10919 6256 81931 91661 54737 125893 5440 147658 5441 4331 57492 1022 2071 2966 7329 2965 23378 6613 2068 5434 5435 10555 8932 90075 5437 2968 2967 2874 404672 113835 902 23067 9282 4297 5931 9370 2648 94239 9070 51082 143689 340252 285676 9533 23517 54145 123 58508 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R 117145 8471 3481 3479 3480 2549 5140 9965 4893 57761 6654 5289 2254 3265 2252 5781 2251 208 27006 8074 5295 2249 5296 2248 2247 2246 5290 152831 5170 8823 5291 8660 30849 2264 2255 2323 2322 54106 10818 9846 3667 8817 26281 SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 96%166520 Signaling by NTRKs 2353 4916 1108 2354 6456 5879 1213 6457 1211 4205 160 161 6714 6014 4893 6654 163 581 6016 3265 5781 9261 2889 673 1399 6195 1432 1398 5898 5899 4803 25759 5594 5595 6300 5978 6464 10818 4914 1175 5906 1173 57498 466 5600 51231 53358 1849 7867 1959 1848 5900 1846 7529 1845 5603 5604 5605 6774 2033 3397 4208 4209 3727 1386 5519 7166 8851 6236 1020 2152 5515 6197 4066 6196 8941 5516 3398 5518 5607 429 10126 3399 8061 1759 10221 4664 4665 23237 1961 1960 5800 7425 25920 5528 5045 5046 5125 6938 26052 116 117 5598 2002 6446 3726 7074 4915 1795 4908 10817 4909 3400 5335 627 2904 1785 6722 2549 135 1958 5802 387 5295 5296 9252 5290 5291 8660 3667 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling 5708 5709 5700 10460 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 4855 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 5695 9978 7314 6500 5687 5688 5689 207 9861 8454 6233 7316 7534 10213 5706 5707 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 96%444257 RSK activation 6195 5170 5594 5595 27330 6197 6196 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%451927 Interleukin-2 family signaling 3718 6772 2185 6774 3932 59067 3561 84868 3635 50615 3578 3636 3581 6775 3716 3601 3600 3965 3563 3560 6654 1437 1439 1438 3568 3567 3562 2885 5295 5296 6777 3559 6776 8503 3558 5290 5291 5293 6464 3717 9846 6655 5777 6850 LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival 808 2770 2781 2773 107 108 10768 109 3708 3709 5566 5045 2793 2792 2791 2790 2788 2787 1432 2786 2785 3055 2784 2783 51764 94235 3569 55970 5567 5568 57105 111 54331 112 5335 113 114 59345 115 2268 2678 917 64174 4067 3710 136 2687 2209 346562 5575 6868 7525 1800 10800 5573 2214 2212 2782 5577 2778 5336 5613 79651 5576 10769 9332 2534 10681 3586 196883 4627 6850 2771 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 96%9609736 Assembly and cell surface presentation of NMDA receptors 817 818 57576 8825 88 55327 1740 2906 8573 2905 2904 2903 4747 2902 320 1742 116443 26960 1741 116444 1739 64130 815 816 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 96%5654696 Downstream signaling of activated FGFR2 4893 6654 2254 3265 2252 5781 2251 27006 5295 8074 2249 2248 2247 10817 5290 2246 5335 8823 2549 2255 10818 8817 26281 MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 96%9683610 Maturation of nucleoprotein 54956 143 2931 2932 56965 83666 79668 84875 54625 7341 7329 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) 22987 9899 9900 6616 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits 55970 3760 3761 2550 3759 3772 54331 59345 3762 3763 3765 3766 3768 2793 2792 2791 3773 2790 2788 2787 2782 2786 2785 2784 2783 10681 51764 94235 9568 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 96%975577 N-Glycan antennae elongation 6484 2683 338596 6480 25834 9334 9331 8128 51046 8703 8704 11282 8702 11320 4249 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 96%1266738 Developmental Biology 8331 337959 1297 7004 112802 8337 337963 7003 337960 728224 8334 100505753 1293 388 440051 1292 8335 2353 440050 1291 1729 728255 5062 100507608 387273 51350 192670 192666 27161 254950 8341 387266 25791 387267 8463 1287 8342 728318 8347 353288 25984 8348 440021 8345 125115 5364 100505724 8874 26523 388818 8340 83899 83895 83897 83896 100533177 9119 51129 8338 147183 338785 440023 85236 284827 8349 389 653240 5879 84616 100131902 4023 85291 23112 85290 85293 160 386684 57690 161 386683 2932 192669 386685 85294 163 85280 319101 7044 374454 5781 386680 2034 386682 386681 386677 3849 8370 386679 386678 386672 1072 386675 57830 386674 342574 2146 85289 3846 1175 998 85285 1173 3860 3858 4343 3859 3850 3013 3851 3852 3853 3854 3855 255626 5567 3856 3857 5568 439915 100132476 3861 643803 3866 6774 3868 3021 3018 3017 3014 474382 201595 10000 8970 128312 4935 27327 22976 83439 55766 8726 8968 5361 7532 2886 27289 51176 7525 207 208 8502 653604 84661 2138 8503 11091 25937 2294 23512 1495 5928 5929 6383 2534 6615 5087 22916 23129 4686 1761 5730 23414 6921 6923 9421 93649 150572 57057 2817 55897 6899 51621 2657 60 2260 7157 8928 10589 375790 4628 79784 10507 6237 3984 3985 6230 6231 6234 9349 6235 6191 7040 6193 6192 6194 9353 1213 23380 57522 51121 1211 6091 9901 6227 80728 6229 6228 11224 200916 6122 6124 6123 6125 25873 140801 3921 4736 678 390748 6130 6133 54766 6132 6135 6134 6137 6136 57504 655 6128 3192 6129 9112 6142 64641 6141 63976 6144 7350 6143 1149 6146 83401 6147 23090 25924 6139 6138 8110 3662 6152 6155 8193 6154 26039 6157 6490 6156 5977 6760 6159 2766 5873 6158 79083 3320 2197 9274 23521 9275 2315 605 140032 54843 6164 6166 6165 5306 6168 5578 6201 6167 6775 8106 6203 6169 6202 116832 6160 3595 6161 6175 3567 9045 6210 6176 6171 6170 6173 51065 6205 404203 5266 6204 4014 6207 6206 26239 6707 84648 6209 353132 6208 353131 6188 6700 6187 6223 643414 6189 11187 6701 6222 6704 6224 6181 643418 6703 6218 3713 6217 6706 6705 643394 63036 353134 861 43847 23254 353133 865 43849 353135 7051 353137 353139 126638 199834 353141 2312 149018 353140 353143 353142 1825 1824 1823 6698 353145 353144 1041 7062 448835 2125 23581 1475 142910 6768 11005 5318 11202 147409 22794 9333 50937 5493 3565 3596 25818 5652 254910 6699 340654 9939 153572 65109 6495 6299 130497 79192 2296 2668 10736 9775 57526 2303 10921 652 3237 3214 55110 3975 5076 5455 4116 3207 10406 25925 255743 5453 5015 2018 3227 6656 3203 2253 3400 6911 2674 6657 2637 26585 9839 51316 7849 23405 129563 9370 597 6909 634 7220 7837 5829 7222 1000 7224 7223 10085 427 6935 6517 7225 727936 7015 79444 387 4308 4838 10637 55997 130399 91 6997 93 6998 57113 9252 199699 9350 5460 3913 3914 57167 3915 7547 2335 79923 7204 3918 2041 284217 10319 2909 3908 3909 7448 3910 3911 3912 10298 3688 8997 6453 219699 90249 1793 5588 22797 6591 1969 6195 51520 1615 5859 4140 4141 5077 7534 1908 200424 29128 7533 5927 3376 359787 3094 168544 124512 7965 1879 1906 3952 57379 7403 10974 9521 285051 7545 27332 5443 2167 1959 4157 84498 3065 9967 1910 3815 27022 1435 5917 257 6926 3735 4161 9255 8320 8600 64321 4286 6862 6663 145258 6662 5346 5454 83881 2627 3397 6732 7030 4160 2058 4159 7942 3685 5747 23053 27 23708 8440 3670 6387 23032 4753 8453 4650 9423 284656 2107 7410 2045 2044 51466 4440 2043 26986 2042 1943 1605 1942 2935 1949 56924 1948 4690 1947 9355 1946 8022 7852 1945 10451 1944 6092 2051 26019 55740 2050 2049 1630 2047 8829 2046 56956 285220 5576 4313 9495 6655 10486 10487 57144 23767 5216 5217 6093 7408 89884 65110 6586 4099 6585 3199 71 9475 3326 4664 4665 4174 4171 5045 5046 4629 8128 1975 1977 7903 10627 1981 8912 8913 8911 64344 103910 4637 112755 1212 775 3312 3955 6804 9037 1785 7546 1595 6721 2254 2252 2249 2247 8660 1742 2255 9846 1741 1739 3672 3673 2672 3570 2313 688 1053 1050 1441 6478 6477 2242 6386 1600 7436 5649 4211 3200 9063 84962 9935 3211 79447 3201 63978 10664 84891 3221 79727 63925 3213 3212 5316 3233 3232 3198 3231 5566 6197 6196 8535 7290 8459 648 6015 4185 1912 9211 1911 163175 55203 5608 8745 203190 53616 80012 9241 84733 268 6045 5598 23135 1029 2113 23466 85358 1051 57332 7074 5335 2904 2549 374 596 1950 28514 182 102 23396 8218 10538 3566 28964 6514 5663 5664 55851 83464 23385 51107 55588 10093 10092 10095 10094 80306 10097 10096 1052 4318 4651 9412 4644 2902 10109 8976 4627 25904 10552 400569 3630 2308 55090 55571 23097 6910 1482 6929 246175 3978 6837 64065 81857 6938 219541 54797 3674 3678 1024 23389 3458 6722 4303 27092 864 10013 10369 10368 10014 59283 10025 27330 892 56896 22885 2676 10001 390874 2675 57556 256297 5621 5080 6928 5623 6927 3280 971 148738 50674 4821 137970 64096 25942 4825 57211 3170 4760 57453 3651 10371 5786 3175 389692 5788 116986 3171 64218 222546 3642 779 3156 56963 84059 29079 4359 7402 10570 79966 57716 54209 6304 5362 4205 8633 4155 9723 3066 5365 5376 7305 55558 84448 1809 59277 220164 1821 1826 55816 10154 8482 9612 55715 4902 1400 9260 9862 5909 6595 80031 6597 9048 9046 6599 1796 6598 285704 3983 948 84441 2122 54815 5054 84246 51564 23019 23493 9443 7022 7021 9861 9441 9442 6233 7316 10213 9440 5706 7020 5707 5708 51586 9043 5709 1013 23462 1496 10398 9439 5700 4207 6925 5701 4617 5702 4618 5704 663 1956 5705 4790 7039 4917 1002 5682 5683 4654 4656 4756 5684 5685 51592 5686 9464 5717 5718 5719 11047 5713 5714 9219 7979 5690 5691 9477 5692 5693 5694 112950 57472 7311 5970 5695 7314 5687 5688 5689 1749 7341 6256 5465 7490 29883 132243 10361 5620 5619 57492 9759 5468 2625 7329 2624 2516 5914 2626 387332 344022 9855 134701 4487 5081 84667 343930 672 145873 10683 9282 5915 5916 2645 2648 4850 3516 4848 4849 4602 10524 1107 79885 1346 891 4853 1108 5347 6456 4233 83933 1499 30011 999 6714 4893 6654 3265 10765 1432 5594 7913 5595 6300 6464 10818 5979 5600 53358 22938 7529 5604 5605 6601 6603 6602 6605 96764 91584 2033 23318 6907 390245 100288687 80205 57459 201516 79670 503627 7703 8648 503835 10891 55211 342900 100033411 7514 151871 10499 284355 51003 10498 79718 10605 6604 4208 3848 4209 4221 8841 9611 23411 6777 6776 1387 23054 5469 85441 4772 4773 5451 55869 6886 8202 3169 5532 2064 7531 7391 8851 1020 8650 24137 6900 27255 11280 994 2048 3897 10752 823 8828 1759 8850 826 1641 5962 2309 1808 3725 3785 4478 3786 3680 6708 6709 55800 8986 4851 285643 6324 9978 6323 7484 1272 286 287 8861 288 100133941 2596 51332 6711 7480 6710 4897 6712 7481 11313 6331 3174 6330 3172 6332 6335 6334 26052 214 6326 5105 8506 6328 6327 6329 7430 6469 4684 7528 23114 57698 3375 57731 6336 8515 54361 10048 6688 50846 6348 9734 9968 9969 89780 782 783 784 785 7471 3549 25 30009 4086 4087 4088 4089 53615 5921 4094 85456 9794 9314 1463 7299 9337 7306 7027 1638 1019 595 1017 896 10046 86 776 1026 1974 1973 7029 1869 6232 90390 26085 92 9125 23332 8289 8516 133522 23122 6736 8085 2887 3690 7094 6778 5617 5452 1832 1830 9114 51606 9550 1829 1828 5317 5440 523 5441 526 527 528 529 8992 5434 728279 5435 3880 5436 533 3881 5437 286887 5438 7026 3882 5439 353323 337879 100288323 5430 83902 54474 5431 5432 337882 5433 337880 81850 81851 3872 3875 643812 4297 1460 140807 1459 3890 1457 3891 3892 4609 353332 5931 353333 121391 10413 83901 83900 3883 3884 3885 4067 3886 94239 3887 9070 3888 3889 728299 162605 337979 337978 337977 337976 337975 23365 100132386 81870 1286 81871 1285 81872 5295 256076 1284 5296 140258 1282 196374 5058 8688 5290 8689 8687 337969 5291 3728 337967 5293 337966 54145 1299 9826 337974 337973 337972 64283 1298 337971 6932 337970 6934 144501 390792 131873 58508 7124 5063 387264 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 96%190704 Oligomerization of connexins into connexons 2697 2706 2705 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs 389 6093 4628 79784 10398 388 3984 3985 4629 387 9475 5500 5058 1072 4660 103910 4627 4659 4637 FORMATION OF PARAXIAL MESODERM%REACTOME DATABASE ID RELEASE 96%9793380 Formation of paraxial mesoderm 5708 5709 5700 5701 5702 5704 5705 5682 5683 5684 5685 5686 5717 5718 5719 8850 11047 5713 5714 9794 7979 5690 5691 5692 5693 5694 1499 4851 5695 5687 5688 5689 10046 9241 22938 84441 652 134701 84667 343930 3955 145873 10683 6862 2033 6911 2260 2648 89780 28514 51176 2043 1387 9861 3516 10213 5706 5707 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription 22938 23462 7088 3065 84441 79885 1024 3280 9734 2033 8850 6907 4609 9794 26960 7089 83933 3091 7311 2648 4851 9978 7314 7091 79718 6500 3066 51564 10046 8841 10013 9611 388585 23493 10014 1387 26508 3516 8454 9612 6233 7316 55869 9759 892 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle 6400 5700 821 5887 7841 91445 6048 55741 80267 10299 10206 56886 2923 267 7844 10956 7311 55757 11236 7314 84447 51035 9695 23193 11253 9761 5589 55768 7415 6233 79139 7316 64772 811 51009 HIV TRANSCRIPTION ELONGATION%REACTOME%R-HSA-167169.4 HIV Transcription Elongation 2963 22916 2962 2068 5434 5435 4686 5436 5437 6827 5438 6749 5439 2968 2967 404672 5430 5431 5432 9150 5433 6917 1025 902 51497 11198 25920 51224 6921 6924 7936 6923 7469 904 5440 5441 4331 1022 2071 6829 8178 2966 2965 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes 6827 2353 6749 55215 9150 6917 1025 51497 11198 8812 3725 25920 5395 51224 6921 4436 6924 4292 7936 6923 7469 904 905 8621 5440 5441 4331 1022 2071 6829 2966 2965 2963 2962 2068 5434 5435 5436 5437 5438 5439 2968 2967 472 404672 5430 672 5431 5432 5433 902 1643 9656 7157 51755 1111 1386 5892 2177 8178 2176 545 CELLULAR HEXOSE TRANSPORT%REACTOME DATABASE ID RELEASE 96%189200 Cellular hexose transport 66035 6517 6513 6523 200010 6514 29988 91749 81031 11182 55974 56606 85414 154091 6527 125206 155184 6515 26291 144195 6524 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 96%5688849 Defective CSF2RB causes SMDP5 6440 729238 653509 6441 1439 1438 6439 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex 6222 6224 6218 6217 6230 6231 6234 6235 6191 6193 1965 8894 6192 6194 1968 6227 6229 6228 3921 8662 8663 8661 8666 8667 6232 8664 8665 27335 3646 51386 8668 8669 10480 1964 2197 140032 6201 6203 6202 6210 51065 6205 6204 6233 6207 6206 6209 6208 6188 6187 6223 6189 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 96%168927 TICAM1, RIP1-mediated IKK complex recruitment 7323 330 7314 1147 7098 7322 3551 7321 7334 8517 7335 7189 148022 8737 329 11035 6233 7316 7311 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 96%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 5708 5709 5700 5701 7321 5702 5704 5705 5682 5683 5684 5685 126374 112399 5686 112398 5717 8994 5718 5719 54583 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 6921 5695 9978 7314 7322 6923 5687 5688 5689 2034 64344 7428 3091 7323 84962 8453 9861 6233 7316 10213 5706 5707 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139915 Activation of PUMA and translocation to mitochondria 23368 7161 27113 7157 7027 7159 8626 7029 1869 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME DATABASE ID RELEASE 96%9025094 Biosynthesis of DPAn-3 SPMs 5743 240 246 239 DASATINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669914 Dasatinib-resistant KIT mutants 3815 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 96%9620244 Long-term potentiation 808 817 2890 818 6714 3084 4900 88 1740 2906 2891 2905 2904 2903 4747 2902 1742 1741 1739 815 816 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 96%5579029 Metabolic disorders of biological oxidation enzymes 126410 95 1586 26873 56603 1588 340665 112812 6916 2232 2230 1589 1585 4143 1583 191 2678 9420 1593 2328 1591 4128 7172 1594 2937 1584 23169 2729 1545 113612 2730 54658 54657 120227 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates 126410 1580 1579 54905 64816 57834 113612 284541 8529 1565 4051 29785 ASP-3026-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717264 ASP-3026-resistant ALK mutants 238 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer 2261 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 96%8875513 MET interacts with TNS proteins 3688 64759 84951 3082 4233 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 96%451326 Activation of kainate receptors upon glutamate binding 808 55970 54331 59345 5330 5331 2793 23236 2792 2791 2790 2788 2787 2782 2786 2785 2900 2784 2899 2898 1742 2897 2783 83988 10681 1741 51764 1739 2901 94235 FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9607240 FLT3 Signaling 8835 10018 84174 3932 10019 2309 5795 10000 6503 27 7311 7314 867 9402 4893 9306 6654 3265 207 5781 208 5295 6777 6776 5290 1027 3055 6233 7316 2887 2323 2322 2534 9846 1445 6850 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 96%111996 Ca-dependent events 808 817 818 107 5567 108 109 5568 84254 5566 111 112 5580 113 5321 3838 114 156 115 5137 5153 5136 26960 5578 5575 10645 5573 5582 5577 814 5594 5613 5576 196883 815 816 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855229 IP6 and IP7 transport between cytosol and nucleus 23636 9972 5903 9631 7175 11097 23511 8086 8021 53371 8480 10762 348995 79902 57122 55746 23279 79023 6396 9883 129401 9688 23225 4927 23165 55706 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 96%69183 Processive synthesis on the lagging strand 5424 6119 5425 5557 5558 6118 10714 2237 57804 5111 3978 23649 6117 5422 1763 MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72172 mRNA Splicing 22938 57794 22826 22827 10262 54883 11325 10236 55749 23658 25804 27258 23524 10450 51690 57703 10465 11157 53938 57819 11193 24148 24144 8899 23020 55100 85313 143884 9879 9410 23398 3550 9092 9416 55234 10181 8559 58509 51340 6936 59286 5093 79576 5094 51691 51593 6434 151903 57461 10713 84844 55702 1655 5411 22916 153527 60625 27238 3183 84811 11017 4686 8175 84950 9128 9129 51729 26017 7737 63932 9130 4236 79706 84081 25949 51503 27316 79171 55696 1659 10992 55094 79165 26121 5725 163859 10523 10284 79753 7536 4670 51747 51634 51759 988 6627 6629 220988 23450 23451 56949 5546 6638 10594 5356 3178 3181 3188 3187 3185 3184 9716 3191 3190 51639 8896 3312 51645 85437 154007 11066 8233 10081 10084 10179 10291 79622 55599 55954 8449 10283 8241 23350 10286 10285 9343 56259 10946 10907 9360 27339 1665 84991 2521 83443 22985 3192 4904 91603 1660 51428 9584 6631 10929 10772 6625 6626 135295 9785 10915 58517 6430 6432 27336 6431 55660 5511 10250 22794 51362 7919 199746 6427 6426 5440 6429 5441 9939 6428 10189 65109 23759 2963 2962 8683 5434 5435 9775 5436 5437 9295 5438 10921 5439 10569 11338 55110 5430 5431 4116 5432 7307 5433 4809 6632 6628 6634 6633 23517 6636 6635 6637 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome 6714 1956 7039 5781 5295 55824 5290 2549 374 685 1950 1445 255324 2069 5829 1839 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 96%9603505 NTRK3 as a dependence receptor 4916 581 25920 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME%R-HSA-9927432.2 Developmental Lineage of Mammary Gland Myoepithelial Cells 374 7039 1950 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta 5330 55970 5331 2793 23236 2792 2791 2790 2788 2787 2782 2786 54331 2785 59345 2784 2783 10681 51764 94235 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME DATABASE ID RELEASE 96%9970672 FXIIa activates plasma kallikrein-kinin system 8331 3013 8337 710 8334 3818 2161 8335 255626 8341 3021 3018 8342 3017 8347 5329 3014 8348 8345 8340 474382 5547 8970 3827 128312 8338 85236 8349 708 8968 3848 2 3015 653604 8370 54145 3273 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 96%3065676 SUMO is conjugated to E1 (UBA2:SAE1) 6613 10055 10054 6612 7341 IRAK4 DEFICIENCY (TLR2 4)%REACTOME%R-HSA-5603041.4 IRAK4 deficiency (TLR2 4) 114609 695 948 6271 7099 929 2243 7097 7096 3146 51135 6279 23643 6280 10333 2244 2266 4615 SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants 5604 5605 5594 5595 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 96%5688890 Defective CSF2RA causes SMDP4 6440 729238 653509 6441 1439 1438 6439 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection 695 10552 10787 8936 71 51517 10152 3071 10163 63916 10006 1793 5879 23191 1398 9844 3055 5594 5595 998 10093 10092 10095 10094 10097 10096 60 10810 2268 7454 7456 5747 917 4067 147179 4620 4650 7410 4641 7525 2214 7409 4651 4690 644150 26999 10451 25 4644 10458 10109 2534 8976 55845 4627 6850 CRMPS IN SEMA3A SIGNALING%REACTOME%R-HSA-399956.3 CRMPs in Sema3A signaling 10570 5361 5362 2932 56896 8851 1020 55558 1809 91584 10371 1400 1808 8829 2242 2534 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 5624 2677 5045 2159 2158 2147 2155 8858 632 5627 2621 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 96%3595172 Defective CHST3 causes SEDCJD 633 1464 1462 1463 10675 9469 63827 1634 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME DATABASE ID RELEASE 96%9725370 Signaling by ALK fusions and activated point mutants 3002 5903 7175 3831 7297 3587 192670 27161 4170 891 22872 26523 3725 4478 50616 7311 7291 6194 1786 9978 4869 7314 1213 6500 1639 4193 57690 192669 10342 9648 2305 5551 7170 5601 7171 29851 51530 1026 5594 5595 80304 5925 10818 4008 5777 471 3799 4343 8878 3065 3726 5599 3662 6772 1051 6774 6238 8496 10817 5335 597 57674 1937 7157 833 3092 57448 5495 5573 53335 238 2885 5295 5296 27436 6801 6776 9451 5290 5291 8454 6233 7316 7535 2335 3586 3667 4627 7414 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 96%9665247 Resistance of ERBB2 KD mutants to osimertinib 3320 55914 2064 11140 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 96%168142 Toll Like Receptor 10 (TLR10) Cascade 1147 5519 2353 4790 351 4792 5515 6197 6196 4793 5516 5518 841 8945 3725 7186 3654 8767 5528 4615 4791 57162 7311 5970 7314 6500 3551 84166 4205 10454 6285 7334 8517 6288 7335 11274 64127 7189 5608 6283 51295 257397 5609 3146 9261 51135 4214 23118 9683 6416 9684 5601 6195 7100 1432 5602 10392 5606 28512 79155 57161 79671 5594 177 5595 121457 246330 81793 5598 28511 3656 9097 2002 466 51231 5600 1849 7867 1848 1846 1845 5604 5599 7157 4208 9252 1386 8454 6233 7316 1326 6885 23291 80216 92610 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610780 Degradation of GLI1 by the proteasome 5708 5709 5700 5701 5567 5702 5704 5568 5705 5682 5683 8650 5566 5684 83737 5685 5686 5717 5718 5719 8945 11047 5713 5714 7979 5690 5691 5692 5693 5694 7311 2735 5695 9978 7314 6500 5687 5688 5689 9861 8454 6233 7316 10213 5706 51684 5707 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 96%975576 N-glycan antennae elongation in the medial trans-Golgi 2525 4248 51046 8703 8704 11282 8702 2517 11320 4247 3972 4249 9486 1081 64377 6484 2683 338596 4124 6480 25834 4122 2530 9334 9331 8128 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript 23636 22916 9972 5903 9631 7175 10482 11097 4686 23511 8086 8021 53371 8480 10762 348995 79902 57122 55746 8189 10898 51692 23279 79023 53981 29894 6396 55339 81608 1977 9883 129401 9688 23225 4927 23165 10189 55706 SIGNALING BY WNT%REACTOME%R-HSA-195721.7 Signaling by WNT 8331 8337 8334 8335 8313 5881 192670 27161 8341 8342 8347 8348 8345 26523 8340 8338 85236 1499 8349 5879 23112 160 161 57690 59349 2932 23072 192669 163 8724 5880 8370 7534 1175 1173 4343 3013 3065 255626 64321 3021 1855 3018 2033 3017 6662 3014 474382 1857 1856 8970 128312 27327 7514 83439 55766 857 8968 4221 51176 207 208 653604 1387 84661 57216 11091 4772 5929 5534 808 5216 7090 5530 5532 54764 81847 8658 80351 79971 51699 9559 9978 55737 7484 7483 2793 50999 2792 2791 2790 7480 7482 7481 2788 2787 2786 80326 2785 2784 2783 51764 94235 54361 55970 1212 324 54331 51384 59345 7855 7976 8321 7473 8322 7472 89780 7475 864 7474 8325 7477 7476 8323 7479 8324 7478 5582 2782 7471 23513 2535 10681 144165 9757 8452 8607 64750 79577 7089 331 123169 7091 1213 1211 64840 4919 6597 4920 81029 9580 27121 79412 83999 343637 1455 27123 9736 83595 11197 10023 50964 8312 9101 54894 8549 6423 6422 5145 6259 6658 5578 6659 5592 23401 5593 5158 8295 5148 55366 3710 57154 51701 284654 607 5330 5331 90780 57680 2780 23236 56998 283149 2775 4040 22943 4041 59352 25776 26108 55553 440193 340419 84133 6736 9861 8454 6233 7316 5579 10213 6885 5706 815 5707 5708 5709 5519 5700 5701 5702 5704 139285 5705 3708 5682 3709 5683 5515 5684 5516 409 5518 5685 5686 5717 5718 8395 5719 166 8945 11047 5713 5714 5525 7979 5526 5690 5691 5527 5692 5528 5693 5529 5694 7311 5695 7314 6500 5687 5688 5689 8290 7088 84870 1460 6657 1459 1457 4609 94239 9070 1454 7015 1452 387 23002 50855 1488 1487 54145 6932 10524 6934