S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation ADI1 APIP MRI1 KYAT1 ENOPH1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1-1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A13;CYP2A6;CYP2A7-1 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) FADS2 ELOVL5 EHHADH-1 ELOVL2 HSD17B12 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation ACAT2 ACAT1 GCDH ECHS1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 INPP5B ITPKB ITPKC MINPP1 INPP5A BPNT2-1 SYNJ1 INPP5F IMPA1 IMPA2 INPP5D ITPKA INPP5J INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS;CBSL CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS RRM2-1 RRM1 DUT DTYMK NME4-1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 DDC TPH1 AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis SLC27A2 ACSBG2 FADS2 ACSM3 ACSL1 ACSM5 ACSBG1 ACSM4 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis GGT5 GSTM4 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 ACAT2 MVK ACAT1 GGPS1 IDI2 PMVK MVD HMGCR HMGCS2 HMGCS1-1 FDPS L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation GSTZ1 HGD TAT FAH HPD NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation ADH4 ADH1C;ADH1B;ADH1A LRTOMT ALDH3A2 ALDH2 MAOB MAOA COMT PNMT N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II NAGK GNPDA1 GNPDA2 AMDHD2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair GAPDH-1 NAXE NAXD URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PLCZ1 PPIP5K1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C IPMK INPPL1 SACM1L PTEN ITPK1 OCRL PLCB3 PLCB4 SYNJ2 PIK3CA INPP5B ITPKB PIK3C3 ITPKC PLCB1 MINPP1 PLCB2 PI4K2A INPP5A IPPK MTMR3 SYNJ1 PIK3R4 PIK3R3 PIK3R2 PIK3R1 INPP5D ITPKA PIK3R6 PIK3R5 INPP5J PLCG2 INPP5K PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH;LOC102724788 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT GPT2 ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing SLC27A4 CERS3 TGM1 ALOX12B CYP4F22 ALOXE3 PNPLA1 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD DHODH UMPS GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation GDA NT5C2 PNP-1 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis IMPA1 IMPA2 ISYNA1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) UQCRC1 NDUFS2 NDUFS1 UQCRC2 NDUFB9 NDUFB8 NDUFB7 UQCRB NDUFB10 NDUFB6 NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFA4L2 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A NDUFC2;NDUFC2-KCTD14 CYC1 NDUFV3 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA3 COX6C UQCRQ NDUFAB1 NDUFS5-1 COX7B NDUFA13 NDUFA11 NDUFA12 COX4I1 NDUFA10 COX6A1 COX7C UQCRFS1 COX8A SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis NME2 NME3 NME5 NME1 NME6 RRM2B NME7 RRM2-1 AK1 AK2 GMPS AK3 AK5 PFAS AK7 AK8 ATIC GUK1 PPAT AK4-1 ADSL PAICS IMPDH1 IMPDH2 ADSS1 RRM1 ADSS2 GART NME4-1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMRK1 NMNAT3 NMNAT2 NMNAT1 NMRK2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt ALDH5A1 GAD1 GAD2 ABAT GLUL GLUD1;GLUD2 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) UBIAD1 COQ3 COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis NME2 NME3 NME5 NME1 NME6 RRM2B NME7 GMPS RRM2-1 GUK1 IMPDH1 IMPDH2 RRM1 NME4-1 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 PSAT1 SHMT2 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME2 NME3 GUK1 DGUOK NME5 DCK NME1 NME6 NME7 NME4-1 AK5 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 DIO1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I CYP4X1 CYP2C9;CYP2C19 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 POR PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP-1 ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GGT5 GSTM3 GSTK1 GSTO2 GSTP1 MGST3 NAT8-2 MGST1 MGST2 GSTT1 GSTT2B;GSTT2 GSTM1;GSTM2-1 GSTA3;GSTA1 GSTA4 ANPEP GSTA3;GSTA5;GSTA1;GSTA2 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate MTHFD1 GART ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2-2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation NME2 NME3 NME5 NME1 NME6 NME7 CMPK1 DTYMK CMPK2 NME4-1 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis GPX4 ALOX15 ALOX12 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1A ATPAF2-2 ATP5MC2 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP6V1D ATP5MG ATP6V1C1 ATP6V1F ATP5ME ATP6V0A1 ATP5PF ATP6V1G1 ATP6V0B VPS9D1 ATP5PD ATP5PB ATP5F1C ATP5F1D ATP6V0E2;ATP6V0E1 ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation SHMT2 SHMT1 MTHFD1 MTHFD1L FPGS L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis PFAS PPAT GART PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis ACAT2 SQLE ACAT1 EBP KCNH7 SC5D DHCR24 DHCR7 LSS FDFT1 HMGCS1-1 FDPS IDI1 MVK GGPS1 IDI2 PMVK MVD HMGCR NSDHL HMGCS2 HSD17B7 LBR TM7SF2 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCS2 HMGCL BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation DCXR AKR1A1 CRYL1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PI4KA PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ACSS3 ACSS2 ALDH3A2 ALDH2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation DBT ACAT2 BCKDHB ACAT1 BCAT1 DLD ACADSB HSD17B10 BCAT2 BCKDHA ECHS1 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 B4GALNT1 ST3GAL6 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 BLVRA HMOX2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 ST8SIA2 ST8SIA3 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis PCYT1B PCYT1A PEDS1-UBE2V1;PEDS1 CHKA AGPAT1 GNPAT AGPS CHKB FAR1 PCYT2 FAR2 ETNK2 ETNK1 CEPT1 SELENOI L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) TDO2 KYNU AFMID KYAT3 ALDH8A1 IDO2 IDO1 AADAT DHTKD1 KYAT1 GOT2-1 HAAO KMO ACMSD ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A13;CYP2A6;CYP2A7-1 HSD17B1 CYP19A1 HSD17B3 HSD17B7 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 ACSL1 ACSM5 ACSM4 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 B3GALT4 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3GALT1 ST3GAL3 FUT6;FUT5;FUT3 FUT2 B3GALT5 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III AKR1B15;AKR1B10 AKR1B1 CYP2E1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT1A MAT2B MAT2A PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS NME4-1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2;ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis TBXAS1 PTGDS PTGR1-1 CBR1-1 PTGES PTGS2-2 PTGES3-1 PTGIS HPGD PTGES2 PTGR2 PTGS1 HPGDS 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation TPTE;TPTE2 INPP4A INPP4B SACM1L INPPL1 INPP5E PTEN OCRL SYNJ2 INPP5B MTMR3 SYNJ1 INPP5F INPP5D MTMR14 INPP5J INPP5K PIP4P2 PIP4P1 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis ELOVL4 TECR HSD17B12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis GPX4 ALOX5 ALOX15 ALOX12 EPHX3 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2E1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGES3-1 PTGIS HPGD PTGES2 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGR1-1 PTGES GGT5 GSTM4 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S EPHX3 CYP2J2-1 CYP2D6;LOC107987479;LOC107987478-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX15B DPEP2 LTA4H PTGS2-2 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI6 PADI3 PADI2 PADI4 PADI1 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 INPP5B ITPKB ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K3 IPPK PPIP5K1 IP6K2 PPIP5K2 IPMK IP6K1 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2-2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 BDH2 BDH1 OXCT1-1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3B2;ALDH3B1 ALDH1B1 PGM2 DERA ALDH3A1 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX5 ALOX15 ALOX12 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine BHMT BHMT2 MTR-1 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation CYP4X1 CYP2C9;CYP2C19 CYP2U1 CYP2S1 CYP1A2 MAOA CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 POR 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ALDH8A1 DHTKD1 ACMSD GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX1 GPX4 GSR GPX7 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT3 NMNAT2 NAMPT NMNAT1 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis CDS1 MBOAT7 MBOAT1 MBOAT2 ABHD5 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM AGPAT1 LPCAT4 GPAT4 LPCAT3 AGPAT5-1 GPAT3 GPAT2 CDS2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt BPGM MINPP1 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III HACL1 ALDH3A2 FA2H GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 G6PC3 PC GAPDHS PGK1 GAPDH-1 ALDOC ALDOB ALDOA PCK1 FBP1 FBP2 BPGM PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I ALDH3A2 ALDH2 AOC3 MAOB MAOA AOC2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE;RPEL1 TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II ELOVL7 TECR ELOVL1 HSD17B12 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) SLC27A2 ACSBG2 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 ACSL1 HSD17B12 ACSM5 ACSBG1 ACSM4 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle OPLAH CNDP2 GGT5 GGCT GCLC GSS GCLM UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 PGM2 PYGB MGAM HKDC1 PYGM PYGL PGM1 HK2 GCK HK1 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation DBT BCKDHB BCAT1 DLD ABAT BCAT2 ACAD8 ALDH6A1 HIBADH BCKDHA ECHS1 HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) ATE1 NAA20 NAA25 NTAQ1 APEH NTAN1 METAP1 METAP2 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2-2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1-1 GOT1L1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 PGM2 HKDC1 PGM1 HK2 GCK HK1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II TSEN2 C2orf49 TSEN54 RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage CDA TK2 TK1 TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis NME2 NME3 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 RRM2-1 RRM1 DUT DTYMK NME4-1 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA3;GSTA1 GSTA4 GSTA3;GSTA5;GSTA1;GSTA2 GSTP1 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation GDA NT5C2 PNP-1 XDH ADA NT5C3A NT5E IMPDH1 NT5C1A IMPDH2 NT5C1B;NT5C1B-RDH14 L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT1A MAT2B CBS;CBSL CTH AHCY MAT2A L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle MAT1A MAT2B ADI1 APIP MTAP MRI1 SRM KYAT1 MAT2A ENOPH1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A BPNT2-1 SYNJ1 INPP5F IMPA1 IMPA2 INPP5J INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMP2 ZFYVE16 BMPR2 BMPR1B ACVR2A SKI SMAD4 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP2 GGT5 LTA4H GSTM4 ALOX5 DPEP1 LTC4S PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B1;HSD3B2 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1;GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II XDH RBP4 RBP5 RBP1 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation ALDH3A2 MAOB MAOA COMT SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX15 ALOX12 EPHX3 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1-1 GOT1L1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHB LDHA;LDHC LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III ALDH3B2;ALDH3B1 ALDH1B1 ALDH3A2 ALDH2 MAOB MAOA SAT2 SAT1 ALDH3A1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKMT1A;CKMT1B CKM CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation DBT BCKDHB BCAT1 DLD MCCC2 AUH BCAT2 IVD HMGCL MCCC1 HMGCLL1 BCKDHA GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASRGL1 GOT1-1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation ADH1C;ADH1B;ADH1A ALDH3A2 ALDH2 MAOA SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK7 AK8 AK4-1 ADSL AK1 ADSS1 AK2 ADSS2 AK3 AK5 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde TDO2 KYNU AFMID IDO2 IDO1 HAAO KMO UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLD1 PLA2G6 PLB1 PLA2G2A-1 PLD3 PLD2 PLCZ1 OC90 JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLCE1 PLA2G2F PLA2G4F PLA2G2D PLA2G12A PLA2G2E PLA2G4D PLA2G4E PLCB3 PNPLA8 PLCB4 PLA2G4A PLCB1 PLCB2 PLCG2 PLCG1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis SQLE FDFT1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1-1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK1 PPCS COASY PPCDC PANK3 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation ALDOC TKFC ALDOB TPI1 SI ALDOA KHK PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage NME2 NME3 TK2 TK1 NME5 TYMS NME1 NME6 NME7 CMPK1 CMPK2 CDA DCK DTYMK NME4-1 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis PCYT1B PCYT1A CHKA CHPT1 CHKB CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization TDO2 ADH1C;ADH1B;ADH1A KYNU NMNAT3 AFMID NMNAT2 ALDH2 MAOB ALDH8A1 MAOA IDO2 IDO1 DHTKD1 TPH2 DDC TPH1 AANAT ASMT CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GCDH ECHS1 POR ACAT2 CYP4X1 ACAT1 CYP2C9;CYP2C19 CYP2U1 ALDH3A2 CYP2S1 CYP1A2 CYP1B1 QPRT NADSYN1 AKR1A1 HAAO KMO NMNAT1 ACMSD FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) SLC27A2 ACSBG2 HSD17B10 ACOX2 SCP2 EHHADH-1 ACOX1 ACAA1-1 HSD17B4 ACSBG1 HADH ECHS1 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine ALDH3A2 DDC MAOB AKR1A1 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 LARS2 GARS1 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I GNPDA1 GNPDA2 AMDHD2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage NME2 NME3 NME5 NME1 NME6 RRM2B NME7 RRM2-1 PNP-1 ADA APRT HPRT1 AK1 AK2 GMPS AK3 AK5 AK7 ADK AK8 GUK1 AK4-1 ADSL IMPDH1 IMPDH2 ADSS1 RRM1 ADSS2 NME4-1 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) SPTLC1 SPTLC3 DEGS1 KDSR CERS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP NME2 NME3 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 DCTD RRM2-1 RRM1 DTYMK NME4-1 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME2 CTPS2 NME3 CTPS1 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME4-1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine CHDH ALDH7A1 SHMT2 SHMT1 BHMT DMGDH TCA CYCLE%BIOCYC%PWY66-398 TCA cycle MDH1 DLD MDH2 FH IDH3G DLST CS SUCLA2 SDHC IDH3B OGDH SDHD SUCLG2 SDHA SUCLG1 SDHB ACO2 IDH3A N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 HADHA HADHB-1 ACSBG1 HADH ACAA2 ECHS1 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis SPTLC1 SPTLC3 DEGS1 KDSR CERS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C;ADH1B;ADH1A SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 FUT2 B3GALT5 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) ACAT2 TDO2 ACAT1 KYNU AFMID ALDH8A1 IDO2 IDO1 DHTKD1 HAAO GCDH KMO ECHS1 ACMSD PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT-1 CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I RBP4 RBP5 RBP1 SDR16C5 ALDH1A3 ALDH1A2 ALDH1A1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST3GAL4 ST3GAL3 B4GALT2 B4GALT3 ST8SIA2 FUT6;FUT5;FUT3 B4GALT1 FUT9 CHST1 FUT1 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME2 NME3 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME4-1 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPB1 UPP1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) FADS2 ELOVL5 FADS1 ACSM3 ACSL1 ACSM5 ACSM4 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis GCNT2 GCNT3 B3GNT2 B4GALT2 B4GALT3 B4GALT1 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis GPI TPI1 HK3 PGAM1 HKDC1 PGAM2 ENO1 ENO2 ENO3 HK2 GCK HK1 GAPDHS PGK1 GAPDH-1 ALDOC ALDOB ALDOA PKLR PFKL PKM PFKM PFKP BPGM HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS;CBSL CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis GCNT3 B3GNT2 B4GALT4 LALBA ST3GAL3 ST6GALNAC6 ST6GAL1 B4GALT2 FUT6;FUT5;FUT3 B4GALT1 FUT2 B3GALT5 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5C2 PNP-1 XDH NT5E IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle SLC25A20 CPT1C CPT1B CPT1A CPT2 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis TYR DCT TRPC1 TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) NDUFAB1 OXSM MCAT ACSF3 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 FUT2 B3GALT5 FUT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 HK2 GCK HK1 TREH LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX4 CYP2C9;CYP2C19 EPHX2 EPHX3 EPHX1 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RDH8 RLBP1 RPE65 DHRS3 DHRS4 RBP4 RBP2 RBP5 RDH12 DHRS9 RBP1 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B1;HSD3B2 HSD17B3 SRD5A2 SRD5A1 CYP17A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME2 NME3 GUK1 NME5 IMPDH1 NME1 NME6 IMPDH2 NME7 GMPS NME4-1 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis LIPC BCO1 PNLIP CES2 CES1 RDH8 DHRS3 DHRS4 RBP4 RBP2 RBP5 RDH12 DHRS9 RBP1 RDH11 RDH10 LRAT CES5A DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 GPX4 ALOX5 ALOX15 ALOX12 EPHX3 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 PIP5K1A PIP5K1B PIP5K1C CDIPT UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II GPI HK3 GALE HKDC1 PGM3 GNPNAT1 GNPDA1 UAP1 GNPDA2 HK2 GCK HK1 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I GOT1-1 CDO1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis SLC27A2 ACSBG2 ACOT2;ACOT1 ACOT4 ELOVL7 ELOVL6 ACSL1 HSD17B12 ACOT7 ACSBG1 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 HOGA1 GOT2-1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F3;CYP4F2;CYP4F12;CYP4F11 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) FADS2 ELOVL5 ELOVL2 HSD17B12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism SLC27A2 ACSBG2 PTGR1-1 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 ACSL1 ACSBG1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PGM2 PNP-1 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation CDA TYMP UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 PLCG1 PIP4P2 PIP4P1 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I SHMT2 SHMT1 MTR-1 ST20-MTHFS;MTHFS ALDH1L1 MTHFD2 MTHFD2L MTHFR MTHFD1 ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT1A MAT2B AHCY MAT2A ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP-1 ADA HPRT1 REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX5 GPX8 CAT GPX1 SOD2 SOD3 GPX7 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C2 PNP-1 XDH ADA NT5C3A NT5E NT5C1A NT5C1B;NT5C1B-RDH14 ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 AKR1B15;AKR1B10 CYP2E1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis SHMT1 TMLHE BBOX1 ALDH9A1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 ITPK1 OCRL SYNJ2 INPP5B ITPKB ITPKC INPP5A IPPK SYNJ1 INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX15B GPX4 ALOX5 ALOX15 ALOX12 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation LIPC PNPLA2 PNLIP LIPF LIPE DAGLA LIPG PNPLA3 PNPLA4 LPL CEL DAGLB CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2-1 NME2 NME3 NME5 NME1 NME6 RRM2B RRM1 NME7 NME4-1 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 TIGAR PFKFB4 PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) SHMT2 TYMS DHFR2;DHFR ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2-1 NME2 NME3 NME5 NME1 NME6 RRM2B RRM1 NME7 NME4-1 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT3 NMNAT2 QPRT NADSYN1 NMNAT1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1-1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) FADS2 ELOVL5 ELOVL7 ELOVL2 HSD17B12 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) GCNT2 GCNT3 ST6GAL2 ST3GAL4 B3GNT2 ST3GAL3 ST6GAL1 B4GALT2 B4GALT3 ST8SIA2 B4GALT1 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III ACSS3 ACSS2 ALDH3A2 ALDH2 ACSS1 CYP2E1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ACSS3 ADH1C;ADH1B;ADH1A ACSS2 ALDH3A2 ALDH2 ACSS1 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation DBT BCKDHB MCEE DLD PCCA PCCB MMUT BCKDHA LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 AOX1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FMO2 FMO3 FMO4 FMO5 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALM-2 GALK1 PGM2 GALE PGM1 GALT UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II GPI HK3 GFPT2 GFPT1 HKDC1 PGM3 GNPNAT1 UAP1 HK2 GCK HK1 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT GPT2 INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) ALDH7A1 AASS AADAT DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation HACL1 SLC27A2 ALDH3A2 ACSM1 PHYH-4 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis GGPS1 FDPS THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1;TYW1B TYW3 LCMT2 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I GDE1 PLAAT2 PLAAT5 ENPP2 PLA2G1B NAPEPLD PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ACAT2 ACAT1 ACADSB ACSM1 ECHS1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis TDO2 KYNU NMNAT3 AFMID NMNAT2 IDO2 IDO1 QPRT NADSYN1 HAAO NMNAT1 KMO LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation SLC27A2 ACSL3 ACSBG2 ACSL1 ACSBG1 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis DDHD1 DAGLA PLCB1 DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) N6AMT1 PNP-1 TRMT112 SLC34A2 SLC20A2 SLC20A1 AQP9 SLC2A1 LOC100509620;LOC112267859;AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I PGM2 PGM1 UGP2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2-2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB MPI GPI PMM1 PMM2 GMPPA CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) SHMT2 SHMT1 BHMT DMGDH SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis ALAD ALAS2 FECH ALAS1 UROD UROS CPOX HMBS PPOX PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation DBT BCKDHB SDSL DLD SDS BCKDHA GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP-1 HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS3 NOS1 ASL ASS1 NOS2 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation DBT BCKDHB MCEE DLD BHMT PCCA BHMT2 PCCB MTR-1 MMUT CDO1 SUOX AHCY MAT2A MAT1A GOT1-1 MAT2B CBS;CBSL CTH BCKDHA TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis ALAD ALAS2 ALAS1 UROS HMBS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 IDI2 PMVK MVD HMGCR HMGCS2 HMGCS1-1 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II FMO1 ADO PPCS ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis MOGAT3 PLPPR2 PLPPR3 MOGAT1 PLPPR4 DGAT2 DGAT1 PLPP4 MBOAT7 PLPP3 MBOAT1 PLPP2 MBOAT2 PLPP1 ABHD5 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 AGPAT5-1 GPAT3 GPAT2 AGPAT1 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 MINPP1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis DDC TH DBH PNMT 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1;TYW1B TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I FMO1 CSAD CDO1 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle GOT1-1 MDH1 MDH2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor NCOA1 MAP4K1 FOXO1-1 FOS RHOA PJA1 TGFBR2 NME1 TGFBR3 RBL2 KAT2B PPM1A ZEB2 ZEB1 TFDP1 RBL1 TFDP2 STRAP CRK CD44 ENG ROCK1 HDAC1 LEF1 MAPK8 FZR1 PARD6A STAMBPL1 YAP1-1 MAPK1 E2F5 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 MAPK14 PML SKI FKBP1A EIF3I CTNNB1 FOSB BCAR1 RB1 ATF2 SPARC ZFYVE9 UBE2D1 TGFBR1-1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC CDC27 SNIP1 AKT1 EP300 SOX9 BTRC MAP3K7 TGIF1-1 JUNB VPS39 SKP1 PDK1 NUP214 PRKCG MAP2K3 MEF2A DAXX MEF2C ANAPC7 PRKCB FOXH1 PRKCD RUNX2 CDC25A RBX1 AR EID2 ZFYVE16 PRKAR1B CCNE1 HGS EWSR1 ANAPC4 ANAPC5 TP53 ANAPC1 ATF3 KPNB1 PPP2R2A;PPP2R2D ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 PIK3R1 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SMAD2;SMAD3 SKIL SPTBN1 SNX6 MAP2K6 HSPA8 TRAP1 WWTR1 TGFB2 JUN SMAD4 CREBBP JUND TGFB1 SMURF2 SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 PTK2 SMAD7 DAB2 SNW1 CDK6 COPS5 CDK4 SP1 CDC16 CDK2 CDK1 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 CDKN1A CITED1 ARRB2 CTCF BRCA1 UBE2D3-1 ING2 XPO1 XPO4 SUMO1 HNF4A BDNF%IOB%BDNF BDNF FOXO3 SHC4 NTRK1 NTRK2 GSK3B IRS1 IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 MAPK8 AKT1 SHC1-1 MAPK1 MAPK3 CCR1%IOB%CCR1 CCR1 PXN ZAP70 GNA14 CCL4L2;CCL4L1;CCL4 CCL8 MAPK14 PTK2 CCL5 CCL23;CCL15 CCL3L1;CCL3L3;CCL3;CCL18 CCL16 CCL26 PRKCD PTK2B CCR1 CCL14 STAT1 SRC NFKB1 MAPK1 RELA CREB3 MAPK3 LEPTIN%IOB%LEPTIN Leptin PIK3R2 PIK3R1 KHDRBS1 ITGB5 SLC2A4 EGFR LEPR ITGAV JAK2 JAK3 SOCS7 PRKCE NCOA3 STAT3 RPS6 PTPN11 RPS6KB1 LEP PDE3A GRB2 MAPK1 MAPK3 MAPK14 PTK2 PRKCD SP1 IRS1 IRS2 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin STAT3 FOXO3 SHC1-1 ATXN2L STAT5B MAP2K2;MAP2K1 MAPK1 MPL GAB1 JAK2 MAPK3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor SOCS4 SOCS5 STAT5A LYN YES1 MTOR EPOR KITLG TEC FES ATF2 GRAP IL7R MAD2L1 CRK AKT1 MAPK8 EP300 MAPK1 MAPK14 PRKCB GSK3B PLCG1 RAF1 SHC1-1 STAT1 SRC RELA PIK3R2 PIK3R1 JAK2 JAK3 RPS6 JUN PTPN11 RPS6KB1 GRB2 STAT5B PTPRU SH3KBP1 WIPF1 CLTC CBLB CRKL SPRED2 GYS1 SPRED1 RPS6KA1 HRAS MATK PRKCA MITF FGR HCK DOK1 PIK3CA RASA1 KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SOS1 GRB7 WAS CSF2RB CBL SOCS1 INPP5D EIF4EBP1 ABL1 FYN SOCS6 CCR7%IOB%CCR7 CCR7 FOXO1-1 MAPK14 FOXO3 MTOR CCL21 ADRB2 GSK3B CFL1 CCR7 CCL19 PTK2B PLCG1 RPS6KB1 MAPK8 AKT1 MAPK1 RELA MAPK3 WNT%IOB%WNT Wnt RHOA YES1 GSK3A YWHAB CCND1 PPP2CB;PPP2CA CHD7 DIXDC1 ILK LEF1 PRKACA-1 AKT1 MAPK8 SOX1 CDH1 RAC1 RSPO1 MAP3K7 WNT5A AXIN1 KREMEN1 DKK1 PAX2 SFRP1 PRKCG SFRP2 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A PRKCB LRP1 CTNNB1 CTBP1 PRKCD LRP5 NLK MESD LRP6 GSK3B FRZB DVL1 DVL2 GPC3 DVL3 PIP5K1B WNT1 WNT2 WNT3 MARK2 WNT4 FZD1 TCF7L2 SMAD1 FZD3 GCKR FZD5 SETDB1 JUP FZD4 CSNK1A1 WNT3A FZD7 FZD6 FZD9 WNT7A FZD8 NFATC2 PPP1CA BCL9 APC PIN1 TCF4 JUN CDK6 PRKCA ARRB2 FAS%IOB%FAS Fas TRAF1 TRAF3 LCK TCP1 TOP1 CSNK2A1;CSNK2A3 MET PLEC PRKN GTF3C3 PARG SATB1 SRF USO1 XIAP GLRX CDC42 CD59 BID PAK2 DEDD ROCK1 EIF4B MBD4 CASP8AP2 DIABLO-1 CFLAR CASP5;CASP4 WEE1 NEDD4 MAPK1 EIF3J BAX MAPK3 FAS PTPN6 PKN2 PKN1 VIM GSK3B MAP2K2;MAP2K1 RASA1 FYN LYN CDC27 AKT1 RAC1 DAXX PRKCD CSNK1A1 PDCD6 CDK11A;CDK11B TIAL1 ARHGDIB MAP3K5 CAST UBE4B PSME3 CSNK2B BTK UBA7 MAX PRKDC STK4 STK3 DEDD2 RIPK1 FADD TIA1 EIF2AK2 BMX EIF2S1 STK24 BCL2 TPTEP2-CSNK1E;CSNK1E BCL2L1 NUMA1 FAF1 HSPB1 FASLG CASP9 CASP7 CASP8 AIFM1 CASP6 CASP10 CASP3 FASTK XPO5 CASP1 CASP2 DFFA RFC1 PARP1 RIPK2 ANXA4 MST1 TRAF2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin RHOA YES1 MTOR MET PLEC YWHAB AKT1 RAC1 VIM YWHAE RTKN ITGB4 PIK3CD LAMC2 LAMC1 PIK3CB PIK3CG PRKCD MYLK3 YWHAQ EPHB2 YWHAH AR IRS1 DSP IRS2 DST RPSA YWHAZ ITGA6 COL17A1 LAMA5 CD151 LAMA2 SHC1-1 LAMA3 PIK3R3 MST1R SRC NTN1 PAK1 ERBB2 CLCA1 SFN EIF4E PIK3R2 LAMB3 PIK3R1 LAMB2 BAD ERBIN LAMB1 EIF6 EGFR SMAD2;SMAD3 PTPN11 GRB2 PTK2 PRKCA PIK3CA CASP3 TP73 EIF4EBP1 ABL1 FYN NGF%IOB%NGF NGF ELK1 PRKCI CREB1 DNAJA3 SP1 FRS2 MAP2K2;MAP2K1 MAPK1 MAPK3 HEDGEHOG%IOB%HEDGEHOG Hedgehog DHH HHIP IHH GLI1 GLI3 GLI2 MED12 SHH CCNB1 GRK2 STK36 BOC PRKACA-1 SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 KIF27 MED6 MED23 CDK8 SMO GAS1 YWHAE CTNNB1 ARRB2 GM-CSF%IOB%GM-CSF GM-CSF STAT5A LYN YES1 TGFBR3 FES GSK3A AKT1 MAPK8 MAPK1 MAPK3 PTPN6 MAP2K3 MAPK14 BCAR1 GSK3B ELK1 MAPK9 PLCG1 RAF1 SHC1-1 STAT1 PXN PIK3R2 PIK3R1 BAD CREB1 JAK2 MAP2K6 STAT3 RPS6KB1 TGFB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 CSF2 SLC2A1 CRKL PARK7 IKBKB DPYSL2 RPS6KA2 RACK1 SPTAN1 PDIA3 PRKCA CHUK SYK VAV1 HCK HNRNPH1 PFN1 EZR STAM2 CSF2RA PRDX3 GANAB CCT5 CSF2RB SH2B2 CBL STAM NFKBIA PTPRC BCL3 CCR9%IOB%CCR9 CCR9 MSN CCR9 FOXO1-1 CD226 ITGB7 MAPK14 MADCAM1 GSK3B EZR RPS6KB1 MAPK8 AKT1 CDH1 CCL25 MAPK1 ITGA4 RDX MAPK3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK STAT5A MAPK14 BMX PTK2 NOS3 TIE1 DOK2 TEK FES NCK1 ELK1 GRB7 RAF1 AKT1 SHC1-1 STAT5B PAK1 MAP2K2;MAP2K1 MAPK1 MAPK3 CCR5%IOB%CCR5 CCR5 CCL4L2;CCL4L1;CCL4 STAT5A PIK3R1 CCL8 CCL5 CCL3L1;CCL3L3;CCL3;CCL18 CCL26 CCL13;CCL2 CCL11 C5AR1 AFP CCR5 CFL1 PSMA5 CD4 STAT3 AKT1 GRB2 MAPK1 MAPK3 PTPN6 MAPK14 IKBKB CHUK SYK PTK2B CCL14 NFKBIA STAT1 RELA IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha ZAP70 STAT5A FOXO1-1 MTOR MAP2K6 RPS6KA5 ERBB3 CRK STAT4 STAT6 STAT3 EIF4B JAK1 RPS6 IFNAR2 MAP2K4 RPS6KB1 AKT1 STAT2 PLA2G4A TYK2 ARHGAP30 STAT5B PRKCQ IFNAR1 MAP2K3 CRKL PRKCD VAV1 IRS1 IRS2 CBL NFKBIA STAT1 EIF4EBP1 TRAIL%IOB%TRAIL TRAIL CSNK2A1;CSNK2A3 CREB1 XIAP BID AKT1 DIABLO-1 CFLAR PRKDC MAP3K7 MAPK1 BEX3 BAX PRKAA1 MAPK3 TRADD RIPK1 TNFRSF11B FADD BCL10 CYCS-1 CHEK2 MAPK14 TNFSF10 IKBKG BAK1 CTSB MCL1 CTNNB1 APAF1 IRF5 ATM VDAC1 DAP3 CASP7 CASP8 AIFM1 CASP10 CASP3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP1 CASP2 CBL NFKBIA PARP1 SRC NFKB1 RELA TRAF2 NOTCH%IOB%NOTCH Notch KAT2B HDAC1 LEF1 EP300 MAPK1 MAPK3 SKP1 RBX1 GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 HEY1 POFUT1 SIN3A CCN3 CIR1 SKP2 PSENEN SMAD1 HES6 NFKB1 TLE1 RELA RING1 FBXW7 SAP30 CUL1 NCOR2 NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 NOTCH4 PSEN2 SMAD2;SMAD3 DTX1 FURIN JAK2 PSEN1 DLL1 DLL3 APH1A DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 STAT3 NCSTN APH1B SMAD4 HES1 HIVEP3 SPEN JAG2 JAG1 ITCH SNW1 M-CSF%IOB%M-CSF M-CSF STAT5A PIK3R1 STAT3 PTPN11 AKT1 GRB2 STAT5B CSF1R CSF1 INPPL1 ETS2 RIPK1 PSTPIP2 FADD GRAP2 MYO18A VIM TFE3 PTK2 GAB3 DNM1 PRKCD MITF CASP8 PTK2B SHC1-1 CBL INPP5D EGFR1%IOB%EGFR1 EGFR1 EPN3 ACTA2 ELF3 PEAK1 MYH9 DOCK1 GRB14-1 RALB MVP RGS16 ASAP1 ATP1A1 PDLIM1 MARVELD2 REPS2 MTA2 PDLIM4 SNCA EGF SPRY4 PPP2R3A HSPE1 TNIP1 SPRY3 SPRY2 SPRY1 ZPR1 STK11 MYC AKT1 TGIF1-1 PRKCG MAP2K3 PRKCB PRKCD ZFYVE16 HGS TP53 PXN PIK3R2 PIK3R1 SMAD2;SMAD3 JUN JUND CAV1 PTK2 DAB2 SP1 CDK2 CDK1 FOXO1-1 FOS RHOA CRK HDAC1 MAPK8 MAPK1 MAPK3 AP2B1 MAPK14 BCAR1 GSK3B IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 SHC1-1 STAT1 SRC NFKB1 RELA KHDRBS1 EGFR JAK2 STAT3 PTPN11 RPS6KB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 SH3KBP1 CLTC CBLB CRKL RPS6KA1 HRAS PRKCA DOK1 PIK3CA RASA1 KIT SOS1 GRB7 CBL SOCS1 EIF4EBP1 ABL1 FYN STAT5A LYN MTOR CFL1 GSK3A YWHAB CDH1 RAC1 ARHGEF4 CTBP1 JUP RIPK1 BCL2 CASP9 ANXA4 LCK MET PLEC CDC42 CD59 NEDD4 PTPN6 PKN2 VIM ITGB4 PIK3CD PIK3CB PIK3CG EPHB2 DSP YWHAZ COL17A1 PIK3R3 PAK1 ERBB2 BAD ERBIN PRKCI CREB1 FRS2 GRK2 DYRK1A RPS6KA2 VAV1 PFN1 STAM2 STAM NOS3 DOK2 NCK1 RPS6KA5 ERBB3 JAK1 STAT2 TYK2 PRKAA1 APP ITCH INPPL1 DNM1 USP6NL ATF1 ITSN2 RPL30 TFRC ARAF HNRNPR ENO1 ELK4 EPS8 GJA1 UBASH3B TFG MPRIP ANKS1A SCRIB KIAA1217 PRKAR1A PARD3 PRKD1 RBCK1 KRT6B;KRT6C;KRT6A SERPINB3;SERPINB4-1 IQGAP1 PRKCZ SLC5A5 LDHA ANTXR1-1 MYO6 PLCG2 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 SHB ENSA PLEKHN1 APPL2 APPL1 ANXA1 ANXA2 PGAM1 EPS15L1 PLSCR1 GPRC5A HNRNPA1-1 TKT PHLPP1 AHNAK HTT RPS27L SNX33 AP2S1 FLNB STX4 RPS2 LDLR DDX3X-1 GSN MCF2 HIPK3 DCBLD2 HIPK2 ABI1 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CDH3 CYSRT1 CDH2 TOM1 GRB10 MAP3K4 MAGI1 PIAS3 DYRK4-1 DYRK1B PRPF4B TOM1L1 TOM1L2 HAT1 PKP2 ADAM9 PKP4 PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG SOCS3 STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 MAP2K5 TNK2 PTPRE CDK5 PTPRA ACTB-1 ALB MAP3K14 RAB5A EIF4G1 BCAR3 ITGB1 CALCOCO2 PTEN PTPN23 PIK3C2B NCK2 SFPQ-1 ACP1 CCDC50 ACTR2 PDCD6IP ITGA3 PKM DSG2 SOS2 SLC25A6 CEBPA CEBPB PRKAA2 WBP2 SRI SLITRK6 CSK RBBP7 CTNNAL1 SH2B1 PTPN18 PTPN1 PPP1R14B PTPN12 BAIAP2 NECTIN1 ERRFI1 AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 RIN1 EPHA1 TLN1 EPHA2 SDC4 ASAP3-1 SDC3 PTTG1IP MYL12B RACGAP1 RALGDS SNX5 VASP INSR PTK6 SPART SMU1 SDC1 CALM1 CALM2 CC2D1A PTPRR HIP1 AP2A1 WASL PTPRK LIMD1 PTPRF OTUD6B GIT1 VAV3 RALBP1-1 MINK1 IL17RD VAV2 CTTN ARHGEF7 ALDOA ARHGEF5 CSTB NEDD9 PRKX SH3BGRL PDZD11 CDV3-1 MAP4K5 EPS15 MPZL1 UBB;UBC MAP3K2 GIT2 MAP3K3 MAP3K1 CAVIN1 CAVIN2 HUWE1 PLEKHA5 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL EPPK1 ESYT1 TJP2 SH3GL3 PRAG1 PEBP1 ARHGAP35 SH3GL2 PDGFRB KIRREL1 APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 SDCBP CALD1 CASKIN2 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 FLOT2 KLF11 PDPK1 LSR ARAP1 EPN1 EPN2 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor NCOA1 TOP1 KAT2B HDAC1 APPL1 FOXA1 CALR-1 CCNH BUB1B-PAK6;PAK6 AHR UXT CCND3 KAT5 ZMIZ1 ZMIZ2 PIAS4 DAPK3 PNRC1-1 GTF2F1 GTF2F2 CTNNB1 TLE5 PIAS1 GSN CDC25B CDC37 IL6ST SF1 GSK3B MDM2-2 HSP90B1 BRINP1 PRDX1 BAG1 LPXN PATZ1 XRCC6 POU2F1 UBE2I HSPA5 XRCC5 NONO SRC PIAS3 PA2G4 NR0B2 RELA CDK9 CDK7 RBAK RNF14 TGFB1I1 FHL2 EFCAB6 TRIM68 RAC3 NELFCD PELP1 NCOA2 HSP90AA1 NCOA6 EGFR PRMT1 NCOA4 ARNT ETV5 SENP1 SLC25A4 NCOA3 DDC TMF1 STAT3 COX5B RCHY1 RNF4 NR2C2 NR2C1 PSMC3IP NSD1 NSD2 NRIP1 FLNA SRY PTEN SPDEF SVIL RANBP9 GTF2H1 STUB1 VIP PARK7 RAN RACK1 CEBPA RB1 CCND1 AKT1 EP300 TGIF1-1 DAXX RUNX2 CDC25A AR CCNE1 SIN3A PXN NCOR2 PIK3R1 PPP1CA SMAD2;SMAD3 TCF4 CDK11A;CDK11B HSPA8 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 JUN SMAD4 CAV1 ESR1 SP1 HSPB1 CASP7 CASP8 CASP3 CASP1 BRCA1 PRKD1 PARP1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 STAT5A LYN CBLB FLT3 ATF1 GAB2 CREB1 ATF2 CEBPA STAT3 JUN AKT1 CBL MAPK1 GAB1 MAPK3 CD40%IOB%CD40 CD40 LCK LYN PIK3R1 MAPK14 PLCG2 IKBKB CHUK SYK FGR JAK3 MAPK9 STAT3 JUN MYC MAPK8 AKT1 NFKBIA MAP2K2;MAP2K1 MAPK1 FYN MAPK3 TNFSF3%IOB%TNFSF3 TNFSF3 TRAF3 TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA LTBR LTB JUN NFKBIA NFKB1 RELA TRAF2 ID%IOB%ID ID RB1 RBL2 SMAD2;SMAD3 CDK2 ELK4 RBL1 PAX5 ELK1 ELK3 PSMD4 MYOD1 ID1 ID4 ID3 HES1 ID2-1 MYF5 ATF3 TCF7L2 G-CSF%IOB%G-CSF G-CSF SYP SOD1 STAT5A LCK IL3RA LYN POM121;POM121C REL PRKCI SOCS3 JAK2 STAT3 JAK1 PTPN11 AKT1 TYK2 GRB2 STAT5B MAPK1 MAPK3 MAPK14 GAB2 TPTEP2-CSNK1E;CSNK1E RPS6KA1 CDK2 SYK HCK SHC1-1 CBL CSF3 CDKN1B INPP5D STAT1 CSF3R PLA2G1B FTH1 CISH EPO%IOB%EPO EPO STAT5A FOXO1-1 FOXO4 BAD FOXO3 SGK1-1 NOS3 MTOR H2BC21 EPOR HCLS1 BRAF JAK2 RPS6KA5 GSK3A STAT3 JUN PTPN11 AKT1 STAT5B MAP2K2;MAP2K1 MAPK1 MAPK3 GAB1 CRKL SYK VAV1 IRS2 RAF1 SH2B2 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma STAT5A PLCG2 SPI1 HOXA10 IFNGR1 MAPK11 EGFR IRF1 IRF2 IRF8 JAK2 CRK STAT6 STAT3 JAK1 MAPK8 AKT1 PLA2G4A PRKCQ MAPK1 MAPK3 MAPK14 CRKL CEBPB RAF1 CBL STAT1 TNFSF1%IOB%TNFSF1 TNFSF1 TRAF3 IKBKG TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA TNFRSF14 LTBR JUN AKT1 NFKBIA NFKB1 RELA TNFALPHA%IOB%TNFALPHA TNFalpha TRAF1 TRAF3 CSNK2A1;CSNK2A3 BID CFLAR PKN1 YWHAE CDC37 YWHAQ YWHAH BRINP1 YWHAZ UBE2I CDK9 CREB1 HSP90AA1 NR2C2 FLNA IKBKB TNFRSF1B RACK1 TNFRSF1A RELB NFKB2 CHUK TRAF5 SYK NFKBIA BCL3 REL RB1 RPL4 SMARCB1 RPS6KA5 RPL8 RPL6 DCAF7 PSMD6 PSMD7 TBK1 PSMD2 AKT1 AKT2 PSMD3 DPF2 BTRC PSMD1 MAP3K7 RPS11 RPS13 SMARCC1 SKP1 SMARCC2 TRADD PSMC2-1 CDC34 KCNQ1 TRIB3 IQGAP2 GLG1 IKBKG CRADD SMARCA4 NKIRAS1 NKIRAS2 PRKCD IKBKE RIPK3 ACTL6A COMMD1 AKAP8 TANK PSMB5 ELP1 LRPPRC KTN1 PSMC3 PSMC1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 MAP3K8 KPNA2 AZI2 FBXW7 KPNA3 CUL1 GTF2I UNC5CL FBXW11 USP2 TRPC4AP TXLNA FANCD2 MAPKAPK2 HDAC2 NUPR1 NSMAF FKBP5 COPB2 PSMD12 PSMD13 TNFRSF11A MAP2K6 RASAL2 BAG4 NLRP4 G3BP2 JUN MCC COPS3 CREBBP ALPL TAB3 TAB2 NFKBIE MAP3K11 NFKBIB HSP90AB1 MCM7 CAV1 TNFAIP3 PPP6C BCL7A PPP1R13L NFKBIZ YWHAG PEG3 TRAF7 TRAF4 RASA3 COPS5 POLR1A RPL30 TRAF6 POLR1B POLR1C POLR1D POLR1E MCM5 PFDN2 BIRC2 TAB1 USP11 MTIF2 HDAC6 TIFA POLR2H POLR2L SMARCE1 SPAG9 UBE2D3-1 RNF25 TNIP2 PRC1 GLB1 SUMO1 PDCD2 PRKCZ TBKBP1 HDAC1 MAPK8 MAPK1 MAPK3 UBE2D3;UBE2D2 MAPK14 PML DDX3X-1 MAPK9 STAT1 SRC NFKB1 RELA EGFR MAP2K5 PTPN11 RPS6KB1 MAP3K14 GAB1 DOK1 STAT5A YWHAB MARK2 MAP3K2 MAP3K3 MAP3K1 RIPK1 FADD FAF1 HSPB1 CASP7 CASP8 CASP10 CASP3 CASP2 TRAF2 GDNF%IOB%GDNF GDNF RET PXN CDC25C TH RPS6KA3 PTK2 MET BCAR1 CDK1 DOK1 CRK JUN PTK2B RPS6KB1 RAF1 NFKBIA MAP2K2;MAP2K1 FYN GAB1 TNFSF8%IOB%TNFSF8 TNFSF8 TRAF1 TRAF3 REL AKT1 RELB BCL3 NFKB2 MAPK1 TNFRSF8 NFKB1 RELA CXCR4%IOB%CXCR4 CXCR4 LCK ITK LYN ITGB2 RHOA PLCG2 ICAM1 LCP2 USP14 CXCR4 NCK1 GNAI1 GNA13 GRK6 VCAM1 FYB1 CCR5 LIMK1 CFL1 ESR2 CXCL12 ACKR3-2 CRK YWHAB STAT4 STAT2 RAC1 SDC4 MAPK1 MAPK3 PTPN6 MAP2K3 PRKCD BCAR1 GSK3B ELK1 PTK2B PLCG1 VAV2 STAT1 SRC NFKB1 RELA ZAP70 PXN PIK3R2 PIK3R1 BAD FOXO3 CREB1 EGFR JAK2 JAK3 HSPA8 STAT3 RPS6 PTPN11 RPS6KB1 STAT5B MAP2K2;MAP2K1 CBLB PTK2 CRKL IKBKB ATF1 RPS6KA2 CHUK VAV1 DOK1 RASA1 ARRB2 WAS CBL NFKBIA INPP5D PTPRC FYN CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 CABIN1 PRKACA-1 CHP1 JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS CALM3;CALM1 IL2 IL4 FOSL1 FKBP1A RCAN1 IL3 CD40LG IFNG IL2RA RCAN2 PTGS2-2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling IL5 COL1A2 CDK4 SP1 SP3 CDK2 DCP1A JUN FOS ATF2 CDKN1A ITGB5 CITED1 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A EP300 AKT1 SNIP1 TGIF1-1 NCOA1 PIAS4 IL10 NCOA2 PIAS3 MEF2C TGIF2 FOXH1 TFE3 FOXO1-1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A CREB1 RBL1 TFDP1 NCOR1 MYOD1 IRF7 ATF3 E2F4-1 DLX1 HDAC2 CEBPB CBFB HDAC1 MAX CTBP1 FOXG1 GATA3 FOXO4 FOXO3 RBBP4 GSC SMAD2;SMAD3 SAP18 RBBP7 NKX2-5 E2F5 SKIL HSPA8 ZBTB17 CDKN2B CREBBP SMAD4 IFNB1-4 VDR ESR1 SMAD7 SKI IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events CCL13;CCL2 CXCL9 IL23R IL24 ALOX12B PIK3R1 CD3E TNF MPO RELA SOCS3 IL18RAP STAT4 IL12B IL12RB1 JAK2 STAT5A NOS2 STAT1 ITGA3 STAT3 IL18 CXCL2;CXCL3;CXCL1-1 IL19 TYK2 NFKB1 NFKBIA IL6 CD4 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RANGAP1 RAN PIAS2 PIAS1 HDAC1 RANBP2 HDAC4 XPO1 UBE2I SUMO1 MDM2-2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events MAPK3 VAV3 MAP3K1 GSN SYK CHUK MMP2 MMP9 RHOA MAP3K14 BCAR1 CD44 PIK3R1 RELA NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 PIP5K1A MAPK1 PTK2B ITGAV RAC1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events MAPK3 ACVRL1 BMPR2 TGFBR1-1 ARRB2 ACVR1 SMAD1 TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA SMAD5 ACVR2B ACVR2A TGFBR2 PPP1CA TLX2 CSNK2B ID1 ENG FKBP1A SMAD4 MAPK1 SMAD7 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase MAPK3 RHOA BCAR1 PIK3R1 CREB1 RET GRB7 IRS1 SRC PRKACA-1 PIK3CA PXN IRS2 RAP1A JUN GRB10 HRAS PDLIM7 NCK1 GAB1 GFRA1 PTPN11 PRKCA FRS2 PTK2 DOK1 DOK4 GDNF DOK5 RASA1 DOK6 MAPK8 GRB2 SOS1 CRK SHANK3 MAPK1 SHC1-1 RAC1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events SDCBP MAPK3 CCL5 COL1A2 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 FGF19 COL4A4 COL7A1 COL6A2 COL6A1 TGFB1 COL5A2 COL4A3 COL4A6 SDC1 COL4A5 COL6A3 HPSE PPIB FGFR4 MET FGFR3 PRKACA-1 MAPK1 LAMA5 COL11A1 COL11A2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS RASA4;RASA4B HRAS SYNGAP1 LGALS1 RRAS PLCE1 PRKCB CALM3;CALM1 PRKCE PRKCA DAB2IP RASA2 NF1 KRAS RIN1 SOS2 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events IL5 COL1A2 SP1 COL1A1 PIK3R1 SOCS3 JAK2 STAT5A PIK3CA IL4 ITGB3 CD40LG PIGR SPI1 ETS1 MYB IL13RA2 JAK3 MYBL1 JAK1 IL13RA1 IL4R ARG1 GTF3A OPRM1 FCER2 AKT1 DOK2 IRF4 LTA RETNLB CCL11 IL10 ALOX15 THY1 IL2RG CBL TFF3-1 SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 MAPK14 PARP14 MTOR AICDA SELP RPS6KB1 BCL6 FES PTPN6 BCL2L1 CCL26 IRS1 CEBPB IRS2 GRB2 SHC1-1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K JAK1 MYC AKT1 PIK3R1 IL2RG RELA MTOR RPS6KB1 NFKB1 BCL2L1 PRKCZ SGMS1 UGCG PIK3CA TERT SMPD1 E2F1 HSP90AA1 RPS6 GAB2 LCK IL2RB FOXO3 BCL2 PTPN11 CALM3;CALM1 EIF3A IL2 IL2RA GRB2 SOS1 MYB SHC1-1 JAK3 RAC1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling MAP2K2;MAP2K1 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 NOS3 EGF BDNF NTRK3 IGF1 VEGFA PIK3R1 AFDN TEK JAK2 STAT1 IL6 PRKACA-1 PIK3CA NRAS IL2 KRAS IFNG IL2RA JAK3 JAK1 RHOA IL2RG IRS1 HRAS GAB2 LCK GAB1 IL2RB PTPN11 ARHGAP35 IGF1R FRS2 KDR IL6R PDGFRB LMO4 IFNGR1 NGF FRS3 IL6ST GRB2 SOS1 RAF1 SDC2 PDGFB GNAI3 SHC1-1 GNAI1 EGFR NTF4 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network EP300 NCOA1 RB1 CAMK2D CDKN1B NOTCH1 KDM1A MAML2 MAML1 GATA6 RUNX2 GATA4 JAK2 RBPJ ASCL1 GATA1 AR HIF1A GHR STAT3 YY1 HEY1 HEY2 NCOR1 RBBP8 MYOD1 HES1 SPEN HES6 TLE1 CD4 PARP1 GAA ARNT HDAC1 E2F1 NCOR2 PTF1A CTBP1 NEUROG3 KDR RCAN1 CREBBP MYB INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB8 ITGB7 ITGB6 ITGB3 ITGA4 ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGB5 ITGA7 ITGA6 ITGAV ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events RAB1A ERCC6L PPP2CB;PPP2CA BUB1B AURKA CDC14B PPP1CB GOLGA2 CDC20 RHOA PAK1 CCNB1 FZR1 PPP2R1A CLSPN FBXO5 ECT2 BTRC BUB1 CENPU NUDC BORA PPP1R12A FBXW11 ODF2 PLK1 TUBG1 CDC25C NDC80 CDC25B SGO1 CENPE TPX2 WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ TPT1 SPC24 ROCK2 INCENP BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events TP53 ATR CDK2 RBBP8 MRE11 PCNA PRKDC BRCA1 UBE2D3-1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 RAD51 CCNE1 FANCD2 EWSR1 ATM S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA GNAI3 GNAI1 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma NTRK1 YWHAE AKT1 GSK3B YWHAB CAMK2A AGAP2 PIK3R1 CCND1 YWHAQ EPB41L1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 BAD PDPK1 STAT5A PRKCD TRPV1 YWHAZ CAMK4 CREB1 SRC PIK3CA NRAS HRAS GAB1 FOXO3 KRAS NGF GRB2 SOS1 SHC1-1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 CD3E IL18RAP TGFB1 STAT4 CD86 STAT3 CD80 IL18 PRF1 CD3G CD3D MAPK9 TBX21 IL13 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 ETV5 IRF1 CD28 JUN HLA-DRA CD247 IL18R1 FOS IL2 PIAS2 IFNG IL2RA MAPK8 CREBBP AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling DES BIRC5 TACC1 NCAPD2 AURKA KIF2C VIM RHOA BUB1 NDC80 SGO1 KIF20A CUL3 NCAPG PEBP1 CDCA8 KLHL13 SMC4 CENPA NPM1-2 NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 INCENP RASA1 AURKC EVI5 AURKB CBX5 SEPTIN1 NSUN2 KIF23 PPP2R5D KLHL9 NCL-1 PSMA3 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events MAP2K2;MAP2K1 MAPK3 DAPK1-1 TRIO PITPNA RHOA WASL PAK1 CAMK2A NTN1 BCAR1 AGAP2 FYN PIK3R1 YES1 MYO10 UNC5A DCC PLCG1 UNC5B UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAPK1 RAC1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway MAPK3 GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA PLCG1 GNA13 S1PR4 CDC42 GNAI3 MAPK1 GNAI1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events MAP2K2;MAP2K1 PDE3B PIK3CG PIK3R6 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network WNT1 ELANE COL1A2 ZFHX3 CBX4 SP1 CDKN2A ATP2B1 SMARCA2 GSTM1;GSTM2-1 HIPK2 KITLG CDK6 MYF6 CCND1 TAB2 TAB1 ADA MPO CDKN1B GATA1 HES1 CD4 NRAS UBE2I KRAS PTGS2-2 SPI1 CDKN1A ETS1 MYB SIN3A MYC EP300 CCNB1 PIAS3 SLC25A3 LECT2 CLTA LYZ-1 YEATS4 NCOR1 ETS2 MYOD1 PPP3CA CA1 TRIM28 CASP6 ANPEP PIM1 CEBPB TOM1 RAG2 CD34 HRAS MAP3K7 PTCRA H2AZ2;H2AZ1 GATA3 PAX5 SND1 BCL2 CCNA1 MAF ADORA2B TFEC KIT MCM4 ZFPM1 MAD1L1 PPID HSPA8 BIRC3 CSF1R CEBPA CREBBP COPA CEBPD LEF1 IQGAP1 NLK MAT2A SKI EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling MAP2K2;MAP2K1 MAPK3 WASL PAK1 PIK3R1 ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 MAP4K4 DNM1 TF SYNJ1 GRB7 SRC PIK3CA PXN RAP1A NRAS HRAS NCK1 RRAS PTK2 KRAS RASA1 CDC42 GRB2 CRK MAPK1 SHC1-1 RAC1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAP3K1 SYK CHUK AKT1 PIK3R1 PDPK1 MAPK14 CLTC FAIM2 MAPK9 FASLG PIK3CB IKBKB CASP8 SRC CASP10 PIK3CA CASP3 SMPD1 RIPK1 FADD IKBKG BID MAP2K7 MAP2K6 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAPK8 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK4 PLK2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway MAP2K2;MAP2K1 MAPK3 KSR1 CRADD MAP3K1 SPHK2 EIF2AK2 MYC PAWR TRAF2 TNFRSF1A AKT1 EGF PRKRA MADD BAX IGF1 NSMAF RB1 TNF RELA BAD PRKCD MAP4K4 NFKB1 NFKBIA PRKCZ CASP8 SMPD1 RIPK1 FADD BID BCL2 ASAH1 TRADD BIRC3 PDGFA MAPK8 SMPD3 RAF1 CYCS-1 BAG4 AIFM1 MAPK1 CTSD EIF2A MAP2K4 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling SYK PRKN FYN BLK YES1 MAOB PARK7 PLD1 SLC6A3 KLK6 PLD2 UCHL1 GRK5 SNCA BAD LYN TOR1A PRKCD SNCAIP FGR HCK TH STUB1 CSNK2A1;CSNK2A3 PLCB2 SRC LCK FKBP1A PPP2R5D PTK2B ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway NFKB1 REL NFKBIA IKBKB SYK SRC PIK3CA LCK PIK3R1 ARRB2 RELA BTRC MAPK14 BCL3 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway RHOA ROCK1 PLD1 CDKN1B PLD2 PPP1R12A SRF PTEN PRKCZ SLC9A1 PARD6A CFL1 PIP5K1B PIP5K1C JUN CCN1 SH3GL2 ITGB1 SCAI MAP2K6 MAP2K3 LIMK2 RDX FOS LIMK1 MSN MRTFA MAPK12 CIT EZR DIAPH1 ROCK2 SLC9A3 ACTA1 MYL2 CDC42 PKN2 MAPK8 PKN1 TLN1 ATF2 F2RL2 PIP5K1A VCL MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B CDH2 LEPR CAPN1 PRLR CSN2-1 TXN CSK PTPN1 EGF INSR FER TRPV6 LEP PIK3R1 NOX4 SPRY2 LAT SOCS3 JAK2 STAT5A STAT3 TYK2 PIK3CA ITGA2B ITGB3 AKT1 RHOA BCAR1 FYN BLK YES1 CAV1 LYN STAT5B FGR HCK IRS1 SRC LCK DOK1 PDGFRB CSF1R GRB2 CRK PDGFB CSF1 SHC1-1 PRL YBX1 EGFR INS;INS-IGF2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events SDCBP MAPK3 FGF23 MMP2 CASK RHOA BAX FGF19 CXCL8 TNFRSF13B EPB41 LAMA1 TGFB1 LAMA3 KNG1 RACK1 CAV2 EPHB2 TRAPPC4 PRKCD FN1 FGFR4 FGFR3 CSF2 SRC PRKACA-1 CASP3 HRAS ITGB1 NF1 EZR ITGA2 RASA1 MAPK8 SDC2 MAPK1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway MAP2K2;MAP2K1 MAPK3 NRAS HRAS FOS PRKCB PRKCA KRAS BRAF RAF1 ELK1 MAP3K8 MAPK1 PTPN7 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network CDK4 CCND1 RB1 CXCL8 SOCS3 NOS2 HBG2;HBG1 HRK ACHE DUSP10 MAPK9 HES1 CSRP2 KAT5 IL6 RUVBL2 CCNA2-1 PDGFRA IL23A JUNB DUSP5 DUSP1 JUN DUSP8 SERPINB5 CUL3 POU2F1 DDIT3 JDP2 MACROH2A1 FOS PPARGC1A TGFB2 JUND MAPK11 COL24A1 GADD45A SELE NF1 IFNG MAPK8 PLAU ATF2 MAPK1 MAPK3 ARG1 EP300 MMP2 MAPK14 CREB1 TH ATF3 BCL2L1 CBFB BRCA1 BCL2 PRKCA ESR1 INS;INS-IGF2 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling EPHA3 VAV3 NGEF EPHA2 RHOA FYN BLK YES1 ROCK1 CBL PLCG1 EFNA5 LYN PIK3CG PIK3R6 FGR HCK SRC LCK CRKL EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 CRK EFNA1 EFNA3 EFNA2 CDK5 EPHA1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I TNF RELA GATA1 STAT3 YY1 NFKB1 NFKBIA PRKACA-1 NCOR2 RANBP2 HDAC4 XPO1 UBE2I SUMO1 RANGAP1 RAN SIN3B HDAC10 SIN3A HDAC11 CHD4 CHD3 EP300 TNFRSF1A SMG5 PRMT5 SIRT4 SIRT5 SIRT6 SIRT1 SIRT2 SIRT3 WDR77 BTRC PPARG FKBP3 HDAC5 HDAC3 GATA2 HDAC8 SAP30 NR2C1 HDAC9 KAT2B HDAC6 HDAC7 MTA2 MBD3 SMURF1 MBD2 NCOR1 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 HDAC1 MAX RBBP4 SAP18 RBBP7 ZFPM1 CREBBP SMAD7 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events PLD1 PLD2 ITGA3 CLTC CTNND1 SLC2A4 ASAP2 ADRB2 KLC1 PIP5K1C CDH1 CTNNA1 ITGB1 SPAG9 EXOC7 AVPR2 RALA-1 MAPK8IP3 TSHR DNM2 SCAMP2 NME1 ACAP1 BIN1 ITGA4 AGTR1 ITGA2 EXOC4 ITGA1 EXOC3 CPE ITGA10 CTNNB1 ITGA11 EXOC6 ITGA8 EXOC5 ITGA7 EXOC2 ITGA6 ARF6 ITGAV ITGA5 VAMP3 INS;INS-IGF2 ITGA9 EXOC1 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling ZFAND5 SGK1-1 SKP2 CSNK1G3 USP7 MST1 CDK2 CSNK1D YWHAE RBL2 CAT YWHAB CSNK1G2 CSNK1G1 RALB BCL2L11 YWHAQ CSNK1A1 SOD2 SFN FBXO32 CDKN1B G6PC1 YWHAG TPTEP2-CSNK1E;CSNK1E YWHAH YWHAZ MAPK9 FASLG IKBKB XPO1 MAPK10 GADD45A RAN MAPK8 CHUK EP300 AKT1 CCNB1 SIRT1 FOXO1-1 KAT2B PLK1 BCL6 FOXO4 RALA-1 FOXO3 CREBBP CTNNB1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway SPHK2 GNAO1 GNAZ GNA12 S1PR5 GNAI2 ABCC1 SPHK1 SGPP1 GNA13 GNA14 SGPL1 S1PR4 GNA15 GNA11 GNAQ S1PR1 S1PR3 GNAI3 S1PR2 GNAI1 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt CHUK YWHAE AKT1 GSK3B YWHAB YWHAQ SFN CDKN1B YWHAG YWHAH FOXO1-1 BAD PDPK1 YWHAZ MTOR GSK3A MAPKAP1 CASP9 AKT2 AKT3 BCL2L1 MLST8 RICTOR SRC SLC2A4 PRKACA-1 KPNA1 MAP3K5 TBC1D4 HSP90AA1 PRKDC FOXO4 FOXO3 RAF1 CDKN1A E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AKT1 RHOA PIK3R1 CCND1 AFDN RAP1B CTNND1 SRC PIK3CA CYFIP2 RAP1A PIP5K1C NCKAP1 CDH1 CTNNA1 WASF2 AP1M1 JUP KLHL20 TJP1 ENAH ITGAE TIAM1 DLG1 CTTN NME1 ABI1 ITGB7 RAPGEF1 CDC42 CTNNB1 VAV2 CRK IQGAP1 ARF6 RAC1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GRK2 SMO BOC GAS1 PIK3CA CDON AKT1 PIK3R1 TGFB2 ARRB2 LRPAP1 STIL DHH PTCH1 HHIP PTCH2 IHH LRP2 PTHLH GLI2 SHH HHAT POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK4 PLK3 PLK2 PLK1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 MAPK9 CYFIP2 JUN NCKAP1 WASF2 MAP2K7 MAP2K6 ABI1 RACGAP1 MAPK8 ATF2 PIP5K1A RAC1 MAP2K4 MAP3K1 WASF1-1 NCF1 NCF2 ARPC1B PAK1 ARHGAP5 BCAR1 ARHGDIA ACTR2 CYBB CYBA NOXO1 IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 ABI2 ARPC3 MAPK14 NOXA1 ACTR3-1 MAP3K11 NOX1 PLCB2 CFL1 PIP5K1B PIP5K1C CDH1 CTNNA1 MAP2K3 LIMK1 CTNNB1 CRK IQGAP1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 RPE65 GRK1 RDH12 GNAT2 RGS9BP GRK7 RDH5 GNB3 CNGB3 PDE6C LRAT CNGA3 GNB5 RGS9 LOC118142757;GUCA1A SLC24A2 GUCY2D PDE6H GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity APC VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 ARHGDIA ITSN1 PLCG1 ITSN2 DOCK6 BCAR3 NME1 ARHGEF25 DOCK9 ARHGAP1 RACGAP1 ARHGAP17 FGD1 CDC42 DOCK10 DOCK11 MCF2L VAV2 GIT1 FARP2 RALBP1-1 MCF2 DNMBP HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network SP1 FLT1 CITED2 EPO EP300 EPAS1 SLC2A1 POU5F1;POU5F1B ELOC-1 PGK1 VEGFA ELOB SIRT1 VHL HIF1AN EGLN1 EGLN3 EGLN2 SLC11A2 MMP14 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ELK1 ARNT KDR CREBBP ETS1 EFNA1 SERPINE1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity SMARCA2 GSK3B EGR1 RACK1 EHMT2 ZMIZ2 TRIM24 KLK3;KLK2 SMARCC1 SENP1 PDE9A TMPRSS2 KAT5 NR2C2 HOXB13 RCHY1 RXRB RXRA SRY JUN RXRG SPDEF POU2F1 SMARCE1 MAP2K6 NR0B1 APPBP2 DNAJA1-1 CARM1 MDM2-2 MAPK8 MAP2K4 NR3C1 EP300 NCOA1 SIRT1 NCOA2 FOXO1-1 GATA2 NR2C1 KAT2B MAPK14 AR HDAC7 REL SRC HDAC1 HSP90AA1 PKN1 CEBPA CREBBP PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway JAK1 SRF PIK3CA PDGFRA JUN PIK3R1 FOS CAV3 SHB PLCG1 SHF CRKL RAPGEF1 CAV1 GRB2 SOS1 ELK1 CRK SHC1-1 CSNK2A1;CSNK2A3 ITGAV SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events FGF23 SRC CASK FYN FGF19 CXCL8 CTTN PSENEN NCAN SDC3 PSEN1 PTN MC4R APH1A POMC NCSTN FGFR4 APH1B AGRP FGFR3 EGFR SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ELK4 TP53 RPS6KA4 RPS6KA5 MKNK1 EIF4EBP1 EIF4E MEF2A KRT8 PLA2G4A MITF USF1 KRT19 MAPKAPK3 MAPKAPK2 HBP1 MEF2C MAPKAPK5 RAB5A ATF6 NOS2 MAPK14 CREB1 SLC9A1 CEBPB JUN DDIT3 PPARGC1A MAPK11 PTGS2-2 ATF2 ATF1 ESR1 GDI1 HSPB1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events BCAR1 IGSF8 CD81 THBS2 DOCK1 THBS1 PRKACB-1 ADAM28 MDK FN1 CD14 YWHAZ JAM2 VCAM1 JAML PRKAR1B PRKAR1A PTPRA SRC PRKACA-1 PXN ITGB1 PTK2 ABI1 ITGA4 TLN1 SPP1 CRK GIT1 PTK2B ARF6 RAC1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network WNT1 LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 IGFBP4 RYK-1 FZD4 WNT3A FZD7 WNT7B FZD6 ATP6AP2 WNT5A KREMEN1 FZD9 FZD8 WNT7A KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network TIMP1 TP53 IL5 EDN1 COL1A2 ELF1 DMTF1 SP1 NTS CDKN2A MMP1 BAG1 PENK CCL13;CCL2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TCF7L2 AGT FOSL2 COPS5 CCND1 BCL2L11 FABP4 MAFG TRIP6 CXCL8 FOSB CDKN1B EGR1 HIF1A CSF2 IL6 JUNB DUSP1 JUN NFATC3 NFATC2 NFATC1 FOS JUND IL2 IL4 FOSL1 IFNG PLAU ATF2 ETS1 MYB NR3C1 MYC EP300 MMP9 IL10 TGFB1 GATA2 CREB1 TH ATF3 PTEN CDK1 CBFB CCN1 MAF ACTA1 CTNNB1 CRTC1 DMP1 MT2A ESR1 GJA1 NPPA IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events SDCBP IL5 PIK3CA PIM1 PIK3R1 PTPN11 CISH IL5RA CSF2RB LYN STAT5B JAK2 STAT5A GRB2 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling ARHGEF7 ARHGEF6 AURKA AKT1 GSK3B CCND1 RUVBL1 NCK2 ILKAP PPP1R12A TNS1 PPP1R14A GIT2 PPP1R14B PPP1R14C ACTN1 CREB1 RHOG PARVA PARVB CKAP5 ZEB1 LIMS4;LIMS1 PARVG RUVBL2 RICTOR NACA PARP1 CDC37 PXN ZYX TACC3 JUN SNAI1 HSP90AA1 ELMO2 LIMS2 XPO1 DIAPH1 ILK CDC42 CTNNB1 IQGAP1 RAC1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events CDH2 GSN PTPN1 RHOA FER PIK3R1 ROCK1 PLCG1 LRP5 CTNND1 PIK3CA PIP5K1C CTNNA1 GRIA2 DAGLA JUP DCTN1 MAPRE1-1 CNR1 PTPN11 CALM3;CALM1 KIF5B CAMK2G AXIN1 CTTN GAP43 DAGLB FGFR1 MYL2 CDC42 MAPK8 CTNNB1 GJA1 RAC1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor RARA RARB PPARA PPARD NCOA1 TNF PPARG TGFB1 RPS6KB1 RXRB RXRA NCOR2 RXRG BCL2 RARG THRB THRA FAM120B ABCA1 SREBF1 MED1 VDR NR1H2 NR1H4 NR1H3 NR4A1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A NCOR2 JUN HDAC4 NR0B1 MED1 CTSD MYC COL18A1 CHUK CALCOCO1 EP300 CD82 MPG SRA1 PHB2 NCOA1 DDX17 PDIA2 NCOA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR PGR TRIM59 NCOA7 TFF1 PRDM15 MTA1 SET-1 HSF2 NRIP1 APBB1 NCOR1 NDUFV3 ATP5PF XBP1 KLRC4;KLRC3;KLRC2;KLRC1 ABCA3 GREB1 C3-1 CEBPB POU4F1 NR0B2 HDAC1 ANP32A;ANP32D POU4F2 ESR2 SOD1 PCNA UBA3 EBAG9 BRCA1 LMO4 SMAD4 PRL ESR1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling ELF1 ANGPT1 NOS3 PIK3R1 TEK TNF RELA STAT5A FN1 ELK1 NFKB1 PIK3CA ITGB1 MAPK8 CDKN1A ETS1 MAPK1 ITGA5 RAC1 MAPK3 MMP2 AKT1 DOK2 PAK1 FYN PLD2 FOXO1-1 STAT5B MAPK14 RPS6KB1 FES GRB7 PXN NCK1 FGF2 F2 PTPN11 ELF2 GRB14-1 PLG PTK2 ANGPT4 ANGPT2 BMX AGTR1 TNIP2 RASA1 GRB2 CRK SHC1-1 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells MAP2K2;MAP2K1 TNFRSF9 CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD3E TNF STAT4 EGR1 BRAF ELK1 PTPN7 PRF1 CD3G CD3D MAPK9 FASLG JUNB JUN NRAS CD247 NFATC3 NFATC2 NFATC1 FOS PRKCB CALM3;CALM1 PRKCE IL2 FOSL1 KRAS IFNG IL2RA MAPK8 MAPK1 MAPK3 IL2RG HRAS IL2RB PRKCA TNFRSF4 B2M GZMH;GZMB-1 IFNAR2 RAF1 EOMES TNFRSF18 CD8A PRKCQ IFNAR1 EGR4 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase MAP2K2;MAP2K1 CAPN2 ARHGEF7 SH3GL1 ARHGEF11 ARHGEF28 ASAP1 PTPN21-1 ARHGAP26 KLF8 CCND1 PIK3R1 PLCG1 RAP1B NCK2 GIT2 BRAF ACTN1 MAPK9 PIK3CA JUN ITGB1 RRAS RAPGEF1 ROCK2 MAPK8 ETS1 ITGB5 MAPK1 ITGAV ITGA5 RAC1 MAP2K4 RHOA WASL PAK1 BCAR1 FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 MAPK8IP3 ARHGAP35 PTK2 BMX ACTA1 RASA1 GRB2 SOS1 TLN1 RAF1 CRK VCL ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMA1 LAMA3 LAMB3 LAMA2 ITGB4 LAMB2 LAMA5 LAMC2 ITGA6 LAMB1 LAMC1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway ATR BLM WDR48 BTRC CENPS-CORT;CORT;CENPS FAAP24 BRCA2 BRIP1 LOC105377022;FANCB CHEK1 FBXW11 USP1 ATRIP FAAP100 FANCI RFC5 RFC3 RFC4 FANCM RMI1 HES1 RFC2 TOP3A XRCC3 RPA1 RPA2 HUS1 PALB2 UBE2T RAD17 RAD1 MRE11 FAN1 RAD9A BRCA1 NBN TOPBP1 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 FANCD2 ATM VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms KRT5 POU2F2 IL1A ITCH TP63 CDKN2A AXL FASN RAB38 GSK3B FOSL2 COL5A1 HBP1 ADA SFN NOTCH1 BRCA2 RACK1 RUNX1 ITGA3 HES1 MRE11 TOP2A DLX5 RRAD STXBP4 MDM2-2 DLX6 TBXT SEC14L2 CCNB2 YAP1-1 PERP BDKRB2 KRT16;KRT14 HELLS TCF7L1 FBXW7 CEBPD IGFBP3 VDR ADRM1 WWP1 PPP2R5A NRG1 ATM CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis TNF PRF1 CASP9 CASP8 CASP10 PARP1 CASP3 RIPK1 BID BIRC2 TRADD SREBF1 CYCS-1 CRADD MAP3K1 GSN TRAF2 VIM TNFRSF1A APP NUMA1 MADD LMNB2 BAX LMNB1 PIDD1 CASP7 SLK CFL2 ARHGDIB CASP1 CASP2 SPTAN1 DFFB DFFA APAF1 GAS2 TOP1 SATB1 XIAP LMNA TFAP2A DIABLO-1 CASP5;CASP4 KRT18 CASP6 BCL2 LIMK1 PTK2 ACTA1 BIRC3 GZMH;GZMB-1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 TRIO ARHGDIA KALRN ELMO1 DOCK1 RASGRF2 ARHGAP9 RASGRF1 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 CHN1 DEF6 VAV1 TIAM2 BCR ARHGEF2 DOCK2 TIAM1 DOCK6 ABI1 ARHGEF25 ARHGAP1 RACGAP1 ARHGAP17 SOS1 VAV2 RALBP1-1 MCF2 RAC1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling MST1 MMP2 MMP9 RHOA THY1 TNF ROCK1 RAP1B JAM2 HCK SELP NFKB1 IL6 RAP1A ITGAM SELPLG ITGB2 LRP1 PLAT MST1R PLG AGER ICAM1 HMGB1-1 CCN2 APOB JAM3 PLAUR PLAU TLN1 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway MAPK3 RHOA PLD1 TIAM1 KALRN NME1 PLD2 PLAUR ARF1 RAB11A RAB11FIP3 PIP5K1A MAPK1 ARF6 RAC1 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells LAT2 MAP2K2;MAP2K1 HCLS1 LCP2 MS4A2 PLPP1 PLA2G1B KLRG1 PTPN13 FER PIK3R1 LAT RELA PLCG1 SPHK1 S1PR1 NFKB1 IKBKB PIK3CA DUSP1 JUN IKBKG MAP2K7 NFATC2 FOS PRKCB BTK MAPK8 MAPK1 MAP2K4 MAPK3 MAP3K1 SYK CHUK AKT1 PLA2G4A FYN CBL PAK2 PLD2 INPP5D LYN PXN VAV1 HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 GRB2 SOS1 RAF1 ITK WIPF1 SHC1-1 CBLB FCER1A FCER1G S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway MAPK3 GNAO1 GNAZ FLT1 GNA12 GNAI2 AKT1 CXCR4 RHOA VEGFA GNA13 GNA14 JAK2 GNA15 GNA11 GNAQ S1PR3 AKT3 SRC PDGFRB PDGFB GNAI3 MAPK1 GNAI1 RAC1 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling PTK2 ITGB7 ITGA4 PXN RHOA MADCAM1 ITGB1 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling MAP2K2;MAP2K1 NTF3 NTRK1 NTRK2 BDNF NTRK3 PRKCI DYNLT1 CCND1 MATK PIK3R1 SQSTM1 FAIM SHC2 SHC3 PLCG1 RGS19 MAGED1 NEDD4L RAP1B ABL1 NGFR ARHGAP32 RIT1 RIT2 EHD4 GIPC1 STAT3 DNAJA3 RHOG DNM1 RASGRF1 PRKCZ PIK3CA NRAS TIAM1 CRKL RAPGEF1 KRAS CDC42 MAPK1 RAC1 MAPK3 RHOA ELMO1 DOCK1 RAP1A HRAS GAB2 GAB1 PTPN11 FRS2 NGF RASA1 FRS3 GRB2 SOS1 MCF2L CRK SHC1-1 NTF4 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events SGK1-1 SYK RHOA FYN BLK PIK3R1 YES1 LAT PLCG1 INPP5D LYN PDPK1 PIK3CG PIK3R6 FGR HCK INPPL1 DAPP1 CYTH3 CYTH2 BLNK PIK3CB PLCG2 PTEN CYTH1 PLEKHA1 SRC PLEKHA2 PIK3CA ARAP3 ADAP1 RAP1A ZAP70 NRAS HSP90AA1 ARF5 HRAS LCK FOXO3 BTK KRAS ARF1 ITK ARF6 RAC1 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events MAPK3 PRLR ITCH FYN PIK3R1 TAB2 JAK2 STAT5B STAT5A NCOR1 PIK3CB PIK3CA ERBB4 ERBB2 LRIG1 WWOX NRG2 GRIN2B MDM2-2 EREG BTC ADAM17 NRG3 DLG4 YAP1-1 NRG4 NEDD4 HBEGF GRB2 MAPK1 SHC1-1 PRL WWP1 NRG1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events MAP2K2;MAP2K1 MAPK3 SYK CCL13;CCL2 PIK3R1 CISH CSF2RB INPP5D PRKACB-1 JAK2 LYN STAT5B STAT5A STAT1 YWHAZ STAT3 CSF2 IKBKB PRKACA-1 PIK3CA PIM1 NRAS HRAS GAB2 FOS PTPN11 KRAS CSF2RA OSM GRB2 IRF8 SOS1 RAF1 MAPK1 SHC1-1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta MAPK12 STMN1 PKN1 EEF2K MAP2K3 MAP3K20 MAP2K6 CCND1 MAPT SNTA1 MAPK13 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction LPP AQP3 LIMA1 EPHA2 MYO6 MGAT3 STX4 VASP HGF EGF PLEKHA7 RHOA CAMSAP3 KIFC3 IGF1 NECTIN2 AFDN ROCK1 ACTN1 MET CTNND1 ZYX CYFIP2 PIP5K1C NCKAP1 CDH1 CTNNA1 NCK1 ENAH IGF1R ABI1 DIAPH1 MYL2 EXOC4 EXOC3 CTNNB1 GIT1 EFNA1 VCL ARF6 EGFR AQP5 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 MAP2K2;MAP2K1 FLT1 NOS3 VEGFA PIK3R1 ROCK1 PLCG1 NCK2 PDPK1 PRKCD BRAF PRKACA-1 PIK3CA MAP2K6 PRKCB CALM3;CALM1 MAPK11 SHB ITGB3 NEDD4 CDC42 MAPK1 PTK2B ITGAV MAPK3 AKT1 RHOA HSP90AB1 FYN PTPRJ CDH5 MAPKAPK2 MYOF HGS CBL AKAP1 CAMKK2 PAK2 VTN PTPN2 CAV1 FBXW11 MAPK14 FES PTPN6 SRC PXN GRB10 HSP90AA1 CTNNA1 NCK1 MAP2K3 GAB1 PTPN11 PRKCA DNM2 KDR PTK2 ARF1 GRB2 RAF1 CTNNB1 VCL IQGAP1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation TP53 TAF4B SERPINI1 CDK4 PFKM EIF4G1 ID2-1 SLC2A1 RUVBL1 KAT5 RUVBL2 SNAI1 NPM1-2 FOSL1 NCL-1 BIRC5 MYC EIF4E EP300 MMP9 BAX CCNB1 EIF4A1 TFRC TRRAP ENO1 BMI1 GAPDH-1 MTA1 CCND2 KAT2A PEG10 UBTF RCC1 TK1 DDX18 CAD ACTL6A NME2 CDC25A SUPT3H PIM1 SUPT7L TERT BCAT1 PTMA HSP90AA1 MAX SHMT1 TAF9 RPL11 IREB2 ODC1 CDCA7 MTDH NBN HSPD1 PRDX3 SMAD2;SMAD3 LDHA NME1 MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 CREBBP HUWE1 SMAD4 EIF2S1 LIN28B GPAM POLR3D RIOX2 NDUFAF2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta DUSP16 PAK3 PRKG1 MAP3K3 PAK1 TRAF6 CCM2 RALB FYN MAP3K12 BLK YES1 TAB1 PAK2 LYN MAPK14 FGR HCK DUSP10 SRC RIPK1 DUSP1 DUSP8 MAP2K6 MAP2K3 LCK RALA-1 MAPK11 CDC42 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) MAP2K2;MAP2K1 EPO GSK3B KITLG FER PTPRO MATK PIK3R1 PIK3C2B SPRED2 SPRED1 GRAP2 MAP4K1 STAP1 SH2B3 SH2B2 BAD EPOR JAK2 PDPK1 TEC STAT5A SNAI2 STAT1 STAT3 PIK3CA CRKL MAPK8 MAPK3 AKT1 MITF CBL SOCS1 LYN RPS6KB1 PTPN6 PTEN GRB10 VAV1 HRAS GAB1 FOXO3 BCL2 PTPN11 DOK1 KIT GRB2 SOS1 RAF1 CREBBP SHC1-1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network MAPK9 PTCH1 BMP4 MAPK8 FGF7 GPC3 FURIN SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events BCAR1 VEGFA NOS2 FN1 VCAM1 TNC F13A1 SAT1 CSF2 TGM2 KCNJ15 VEGFC VEGFD ADAM2 SRC ADAM15 PXN ADAM12 ADAM8 PAOX ITGB1 CSF2RA SPP1 RAC1 ITGA9 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining DCLRE1C XRCC4 POLM PNKP PRKDC LIG4 DNTT APTX APLF POLL NHEJ1 XRCC6 XRCC5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) MAP2K2;MAP2K1 APC HGF PTPN1 PRKCI PIK3R1 PLCG1 RAP1B EGR1 NCK2 BAD PDPK1 MET INPPL1 AKT2 MLST8 PRKCZ PIK3CA JUN SNAI1 SH3KBP1 CRKL RPTOR RAPGEF1 DEPTOR AKT1S1 NUMB ARHGEF4 CDC42 RIN2 MAPK8 KPNB1 EPS15 ETS1 PAK4 MAPK1 RANBP9 RANBP10 MUC20 RAC1 MAP2K4 MAPK3 MAP3K1 EIF4EBP1 EIF4E AKT1 RHOA WASL PAK1 BCAR1 PTPRJ HGS CBL RAB5A PAK2 INPP5D PTPN2 MTOR SRC PARD6A PXN RAP1A CDH1 HRAS SH3GL2 CTNNA1 GAB2 NCK1 GAB1 PTPN11 PTK2 GRB2 SOS1 RAF1 CTNNB1 CRK F2RL2 SHC1-1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway MAPK3 GSN PTPN1 EGF WASL PAK1 PIK3R1 PLCG1 NCK2 STAT1 STAT3 PTPN6 PIK3CB SRC PIK3CA PIP5K1C NRAS HRAS NCK1 GAB1 PTPN11 PTK2 KRAS RASA1 GRB2 SOS1 TLN1 GNAI3 MAPK1 SHC1-1 GNAI1 EGFR PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events AKAP13 GRK3 SNX1 GNAO1 GNAZ GNG2 SNX2 GNA12 PRKCG GNAI2 VASP TRPC6 NOS3 F2R RHOA PLCB3 GNB1 ARHGEF1 ARHGDIA PLCB1 PIK3R1 ROCK1 GNA13 GNA14 GNA15 PRKCD GNA11 GNAQ DNM1 PLCB2 PIK3CA ZYX PRKCB F2 PRKCA DNM2 ROCK2 MYL2 PKN1 F2RL2 GNAI3 GNAI1 ARRB1 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events SDCBP CCL5 MMP9 CXCR4 RHOA SDC4 TFPI FGF6 CXCL12 TNFRSF13B LAMA1 LAMA3 THBS1 PRKCD MDK FN1 GIPC1 ACTN1 TNC ADAM12 ITGB1 FGF2 F2 FZD7 PRKCA DNM2 PLG PTK2 FGFR1 ITGA5 RAC1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway TP53 ATR SKP2 CSNK1G3 USP7 CDKN2A CDK2 CSNK1D GSK3B HIPK2 CSNK1G2 CSNK1G1 CSNK1A1 TPTEP2-CSNK1E;CSNK1E ABL1 CHEK1 PRKCD YY1 MAPK9 KAT5 CCNA2-1 RCHY1 MDM2-2 MAPK8 PPP2CB;PPP2CA EP300 AKT1 PRMT5 DYRK2 CSE1L SETD7 UBE2D1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A KAT2B MAPK14 DAXX RPL23 FBXO11 SMYD2-1 PPM1D PTPA COP1 E4F1 RPL5-1 TRIM28 TTC5 CCNG1 PIN1 MDM4 RPL11 CREBBP HUWE1 ATM CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes IL5 CDK4 ITCH PTPN1 IRF4 TNF CXCL8 PPARG EGR1 EGR2 CSF2 CREM FASLG TBX21 CASP3 DGKA JUNB SLC3A2 E2F1 JUN PTPRK BATF3 IKZF1 POU2F1 GBP2;GBP3;GBP1 NFATC3 GATA3 CTLA4 NFATC2 EGR3 NFATC1 FOS FOXP3 CALM3;CALM1 RNF128 IL2 MAF IL4 FOSL1 IL3 CD40LG IFNG IL2RA PTGS2-2 CBLB PRKCQ EGR4 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway MAPK3 GNAO1 GNAZ IRS1 GNA12 GNAI2 JUN RHOA PAK1 FOS CDH5 GNA13 GNA14 GNA15 MAPK14 MAPK8 GNA11 GNAQ ELK1 GNAI3 MAPK1 S1PR2 GNAI1 RAC1 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 PLCB3 GNB1 PLCB1 PIK3R1 PLCG1 AR CREB1 PLCB2 PLCG2 SRC PIK3CA HRAS FOS PELP1 GNRH1 PTK2 SHBG CDC42 RAF1 GNAI3 MAPK1 GNAI1 RAC1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events TP53 PLK3 CHEK2 CDC25C CCNE1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 COL1A2 DMTF1 SP1 CDKN2A MMP1 EP300 NOS3 MMP2 CCL13;CCL2 MMP9 FOSL2 CCND1 CXCL8 LAMA3 IL6 CCNA2-1 JUNB JUN NFATC3 NFATC2 ITGB4 NFATC1 JUND FOSL1 TXLNG THBD HMOX1 LIF USF2 PLAUR DCN MGP PLAU IVL ATF4 GJA1 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway TP53BP1 SMC1A TERF2 UBE2N YWHAB BLM ABL1 CHEK2 CDC25C COP1 RBBP8 TOP3A KAT5 TRIM28 CDC25A DCLRE1C RAD17 CTBP1 BID XRCC4 MRE11 RAD9A BRCA1 MDM2-2 NBN RAD50 MDC1 ABRAXAS1 RNF8 FANCD2 SMC3 UIMC1 ATM HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha CRADD TRAF1 CHUK TRAF2 TNFRSF1A MAP3K14 CASP7 TNF RELA CASP2 APAF1 DAXX CASP9 NFKB1 FASLG NFKBIA CASP8 CASP6 CASP3 MAP3K5 RIPK1 FADD CD247 BID MAP2K7 CFLAR BCL2 FAS TRADD BIRC3 MAPK8 CYCS-1 BAG4 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling IKBKB CHUK BGN LY96 IRAK4 TICAM1 RHOA IKBKG TIRAP TLR1 VCAN SAA2;SAA1 IRAK1 IRAK2 HSPD1 TLR6 TLR4 S100A9 MYD88 HMGB1-1 S100A8 TLR3 TLR2 CD14 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events JAK1 TNF TGFB1 STAT4 IL12B IL12RB1 EBI3 JAK2 IL27 STAT5A IL27RA IL12A STAT1 IL12RB2 STAT2 STAT3 IL18 TYK2 TBX21 IL6 IL1B IL17A GATA3 IL2 IFNG IL6ST P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling TP53 NTF3 NTRK1 MMP7 YWHAE BDNF TRAF6 PRKCI PIK3R1 BCL2L11 SQSTM1 IRAK1 MAGED1 MYD88 NGFR BAD FURIN PRDM4 ZNF274;ZNF74 SMPD2 CASP9 RIPK2 NSMCE3 MAPK9 MMP3 IKBKB OMG PRKCZ RHOC RHOB PIK3CA CASP3 MAG BEX3 MAGEH1 IKBKG RTN4 NDN LINGO1 SORT1 BEX2;BEX1 MAPK10 ADAM17 PSENEN BIRC2 PSEN1 APH1A MAPK8 CYCS-1 NCSTN APH1B RAC1 CHUK APP AKT1 RHOA ARHGDIA APAF1 PRKACB-1 XIAP DIABLO-1 CASP6 E2F1 PLG NGF BIRC3 SHC1-1 NTF4 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway APC LRP6 PIP5K1B GSK3B CUL3 FZD5 CSNK1G1 RANBP3 WNT3A KLHL12 NKD2 DVL1 AXIN1 DVL2 DVL3 PI4K2A CAV1 CTNNB1 GSK3A PPP2R5A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway CDH2 MAPK3 FGF23 AKT1 MMP9 CAMK2A PIK3R1 FGF19 SPRY2 CBL PLCG1 RUNX2 STAT5B PDPK1 STAT1 FGFR4 FGFR3 CTNND1 SRC PIK3CA JUN CDH1 GAB1 FOS PTPN11 FRS2 CTTN KLB FGFR1 FGF1 RPS6KA1 NCAM1 PLAUR IL17RD GRB2 PLAU SSH1 SOS1 SDC2 SPP1 FGFR2 PAK4 MAPK1 SHC1-1 PTK2B ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events ACVR1 SMAD1 FKBP1A SMAD9 SMAD5 SMAD4 AMHR2 AMH BMPR2 TLX2 BMP7 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDKN2A CDK6 CCND1 KDM1A KLK3;KLK2 TMPRSS2 CASP8 UBE2I CARM1 PIAS1 MED1 RANBP9 PTK2B HIP1 TGFB1I1 FHL2 UBE3A VAV3 RPS6KA3 CCND3 GSN ZMIZ1 PAWR NKX3-1 APPL1 AKT1 NCOA6 NCOA4 TGIF1-1 LATS2 CTDSP1 PIAS4 CTDSP2 MAK NCOA2 ZNF318 PIAS3 SNURF HNRNPA1-1 FKBP4 KDM3A TMF1 KDM4C-1 PRDX1 PATZ1 SVIL PA2G4 TCF4 AR CMTM2 NRIP1 SRF UBA3 PRKDC BRCA1 PELP1 XRCC6 XRCC5 CTNNB1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes AKT2 CTNND1 SRC PIK3CA ZYX VASP AKT1 RHOA CDH1 CTNNA1 JUP FYN PIK3R1 PLCG1 CTNNB1 CASR FMN1 PIP5K1A AJUBA EGFR RAC1 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events TIMP1 JAK1 MYC AKT1 MITF PIK3R1 PIAS3 SOCS3 FOXO1-1 JAK2 PRKCD MAPK14 STAT1 HCK STAT3 CRP HSP90B1 TNFSF11 TYK2 LBP A2M BCL2L1 MCL1 IL6 FGG PTPRE PIK3CA CEBPB IRF1 JUNB JUN VAV1 GAB2 MAP2K6 GAB1 FOS PTPN11 MAPK11 IL6R PIAS1 LMO4 GRB2 IL6ST SOS1 CEBPD RAC1 MAP2K4 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA3 EFNA5 EPHA2 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway ATR PPP2CB;PPP2CA CDK2 YWHAB PPP2R1A CLSPN BTRC BRCA2 CHEK1 FBXW11 ATRIP PLK1 YWHAZ CDC25C RFC5 RFC3 RFC4 RFC2 RPA1 CDC25A CCNA2-1 RPA2 SMARCAL1 HUS1 MCM7 CEP164 TIPIN RAD17 CDC6 RAD1 PPP2R2B TIMELESS RAD9A MCM2 MDM2-2 NBN TOPBP1 RAD51 FANCD2 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin APC LRP6 CSNK1D GSK3B FZD5 CSNK1A1 CUL1 WNT3A SKP1 DVL1 BTRC AXIN1 AXIN2 DVL2 TPTEP2-CSNK1E;CSNK1E DVL3 CTNNB1 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE AKT1 PTPN1 IGF1 BCAR1 PIK3R1 NCK2 RACK1 BAD PDPK1 PRKCD YWHAZ RPS6KB1 PRKCZ IRS1 PIK3CA PXN IRS2 GRB10 HRAS PTPN11 PRKD1 IGF1R PTK2 CRKL GRB2 SOS1 RAF1 CRK SHC1-1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K2;MAP2K1 MAPK3 IL1B MAP2K7 MAP2K3 MAP2K6 CALM3;CALM1 TNF ANTXR2 CASP1 ANTXR1-1 NLRP1 PGR VCAM1 IL18 MAPK1 MAP2K4 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods RPE65 GRK1 RDH12 RGS9BP RDH5 GNB1 LRAT GNB5 RGS9 LOC118142757;GUCA1A SLC24A1 GNGT1 SAG CNGA1 RHO PDE6B PDE6A GNAT1 CNGB1 GUCY2D GUCA1C FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network FOXM1 MAP2K2;MAP2K1 CENPB BIRC5 CKS1B SKP2 CDK4 NEK2 SP1 GAS1 MYC CDKN2A H2BC1 XRCC1 CDK2 EP300 MMP2 CENPF CCNB1 CCND1 RB1 BRCA2 CHEK2 PLK1 CDC25B GSK3A CCNA2-1 ETV5 CDK1 NFATC3 FOS CENPA CCNB2 AURKB CREBBP HSPA1A;HSPA1B CCNE1 LAMA4 ESR1 ONECUT1 TGFA IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GRK2 GNG2 PRKCG GNAI2 CXCR1 AKT1 PLCB3 GNB1 PLCB1 CXCL8 ARRB2 CBL PLD1 RAB5A GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 PRKCB PRKCE PRKCA ARRB1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions SPON2 ICAM2 ICAM3 ICAM4 F11R THY1 FGB FGA F10 GP1BA PROC TGFBI KNG1 VCAM1 FGG C3-1 CCN1 ITGAM ITGB2 PLAT ITGAL ITGAX ICAM1 CD40LG JAM3 PLAUR ITGAD PLAU INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport STX4 YWHAE AKT1 GSK3B INSR YWHAB PRKCI YWHAQ SFN YWHAG YWHAH ASIP PPP1R3A GYS1 LNPEP TRIP10 VAMP2 YWHAZ RHOQ AKT2 PRKCZ SLC2A4 TBC1D4 CALM3;CALM1 STXBP4 PPP1CC INS;INS-IGF2 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway MAP2K2;MAP2K1 PAG1 PIK3R1 AFDN RAP1B SPHK1 ABL1 NCK2 JAK2 STAT5A STAT1 S1PR1 STAT3 PIK3CB PIK3CA CYFIP2 NCKAP1 WASF2 MAP2K7 MAPK10 CTTN ABI1 RAPGEF1 ITGB3 MAPK8 MAPK1 ITGAV MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA EIF2AK2 RHOA ARPC1B PAK1 BCAR1 ARHGDIA PPP2R1A BLK PTPRJ ACTR2 ARPC4 ARPC5 PTPN2 BAIAP2 ARPC2 LYN ARPC3 ACTR3-1 FGR HCK SRF PTEN SRC RAP1A GRB10 HRAS PPP2R2B NCK1 GAB1 PTPN11 PRKCA DOK1 RASA1 GRB2 SOS1 CRK SHC1-1 CSK YWHAE PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PRKCD BRAF YWHAZ USP6NL ELK1 SLA ACTN4 SLC9A3R2 SLC9A3R1 RAB4A DOCK4 MAPK9 MYOCD ARAP1 ACTA2 SIPA1 JUN NRAS FOS PRKCE JUND KRAS VAV2 MYC PLA2G4A WASL FYN YES1 CBL RAB5A STAT5B PIK3CG PIK3R6 EPS8 PIN1 LCK LRP1 ARHGAP35 DNM2 PDGFRB RAF1 PDGFB IQGAP1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVR1 FKBP1A ACVRL1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway NECTIN2 PIK3R1 F11R AFDN RAP1B SRC PIK3CA PTPRM CLDN1 PVR RAP1A PIP5K1C CDH1 NECTIN3 CTNNA1 NECTIN1 PTK2 PDGFRB RAPGEF1 ITGB3 CDC42 CTNNB1 TLN1 VAV2 CRK PDGFB FARP2 IQGAP1 ITGAV RAC1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway MAP2K2;MAP2K1 PAG1 CSK TRAF6 PIK3R1 RELA MAP4K1 PDPK1 ELK1 DAPP1 BLNK NFKB1 PLCG2 NFKBIA IKBKB PIK3CA JUN IKBKG PPP3CB PPP3CC CARD11 NFATC1 FOS BCL2A1 BCL10 CALM3;CALM1 MALT1 BTK CD79B CAMK2G CD79A CD19 SH3BP5 CD72 IBTK PTPRC CD22 MAPK8 NFKBIB VAV2 ETS1 MAPK1 RAC1 MAPK3 POU2F2 MAP3K1 SYK CHUK AKT1 INPP5D LYN MAPK14 CSNK2A1;CSNK2A3 PPP3CA PTPN6 PTEN HRAS MAP3K7 DOK1 RASA1 GRB2 SOS1 RAF1 SHC1-1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity AKAP13 ARHGEF10 VAV3 FARP1 NGEF ARHGEF12 ARHGEF17 ARHGEF11 PLEKHG6 ARHGEF28 ARHGEF18 MYO9B TRIO NET1 RHOA DLC1 ARHGEF3 ARHGAP5 ARHGEF1 ARHGEF5 ARHGDIA ARHGDIB ECT2 CDKN1B ARHGAP9 ARAP1 ABR ARAP3 DEF6 VAV1 BCR ARHGEF2 ARHGAP35 ARHGEF25 ARHGEF15 ARHGDIG ARHGEF10L MCF2L VAV2 ARHGAP6 ARHGAP4 OPHN1 ARHGAP8;PRR5-ARHGAP8 MCF2 SRGAP1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin STXBP1 RAB3GAP2 STX1A VAMP2 CHRNA1 UNC13B RIMS1 SNAP25 SYT1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway SKP2 CCND1 NOTCH1 KDM1A MAML2 MAML1 RBPJ FURIN YY1 DNM1 RBBP8 SPEN ADAM12 NCOR2 IL4 PSENEN NUMB APH1A FBXW7 NCSTN EPS15 CDKN1A APH1B ITCH MYC EP300 CBL BTRC DNER ADAM10 NOTCH2 NOTCH3 ENO1 NOTCH4 DTX1 DLL1 DLL3 DLL4 MARK2 JAG2 NCOR1 JAG1 CNTN6 MYCBP-1 DLK1 MIB1 MFAP5 MFAP2 NEURL1 CNTN1 HDAC1 LNX1 CTBP1 PTCRA GATA3 CUL1 SKP1 RAB11A GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network MDK GPC2 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 JAK1 ELF1 CCND3 SP1 MYC LTA CDK6 PIK3R1 IL2RG STAT5B STAT5A CCND2 PRF1 FASLG BCL2L1 CCNA2-1 PIK3CA GAB2 LCK IL2RB FOXP3 BCL2 PTPN11 IL2 IL4 IL2RA GRB2 SOS1 SHC1-1 JAK3 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events MAP2K2;MAP2K1 MAPK3 AKT1 CHRNA1 PIK3R1 BAD JAK2 MTOR STAT3 MAPK9 PIK3CB SRC PRKACA-1 PIK3CA JUN NRAS DOCK7 HRAS PPP3CB ERBB3 ERBB2 CHRNE USP8 FOS NRG2 RNF41 PTPN11 NFATC4 MAPK10 NF2 KRAS CDC42 MAPK8 GRB2 SOS1 RAF1 MAPK1 SHC1-1 RAC1 NRG1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events PPP2CB;PPP2CA GNG2 PRKCG GNAI2 VASP AKT1 PLCB3 GNB1 PLCB1 PPP2R1A CXCL8 ARRB2 CBL RAB5A PLD2 ELMO1 GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 DOCK2 PRKCB PRKCA CXCR2 RAB7A RAB11A ARRB1 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC3 SDC1 SDC2 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions COL1A2 COL1A1 VEGFA SDC4 F11R COL4A1 THY1 FGB FGA LAMB1 COL4A4 VTN TGFBI SPHK1 COL4A3 COL4A6 THBS1 SDC1 COL4A5 FN1 TGFBR2 TNC FGG PVR CCN1 ITGA2B KDR HMGB1-1 PDGFRB ITGB3 IBSP EDIL3 PLAUR L1CAM PECAM1 PLAU CD47 SPP1 FBN1 PDGFB LAMA4 ITGAV LAMC1 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events MAP2K2;MAP2K1 CDK2 PIK3R1 CISH SOCS3 STAT5A STAT1 STAT3 MAPK9 PIK3CA JUN NRAS FOS PRKCB PRKCE IL2 MAPK11 KRAS IFNG IL2RA MAPK8 MAPK1 PTK2B JAK3 JAK1 MAPK3 MYC SYK DOK2 RHOA FYN MAPKAPK2 IL2RG SOCS1 STAT5B MAPK14 IRS1 IRS2 HRAS GAB2 LCK IL2RB BCL2 PTPN11 RASA1 GRB2 SOS1 RAF1 IKZF3 STAM2 SHC1-1 SOCS2 STAM GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC2 GPC3 GPC1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway NONO NR1D1 ATR NPAS2 ARNTL PER2 PER1 CRY2 CRY1 WDR5 CLOCK TIMELESS TPTEP2-CSNK1E;CSNK1E BHLHE40 CHEK1 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CCR5 IL1R1 CCL3L1;CCL3L3;CCL3;CCL18 CD3E RELB CCL4L2;CCL4L1;CCL4 HLX RELA GADD45B GZMA IL18RAP NFKB2 STAT4 GADD45G IL12B IL12RB1 JAK2 STAT5A NOS2 IL12A STAT1 IL12RB2 STAT3 IL18 CD3G CD3D RIPK2 TYK2 NFKB1 FASLG TBX21 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 IL1B HLA-DRA CD247 IL18R1 MAP2K6 FOS IL2 IL4 IFNG IL2RA ATF2 SPHK2 IL2RG SOCS1 STAT6 MAPK14 MTOR MAP2K3 LCK IL2RB RAB7A B2M GZMH;GZMB-1 EOMES CD8A BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions CCN1 MADCAM1 TGFBR1-1 VTN ITGB8 ITGB7 ITGB6 ITGA4 SDC1 EDIL3 PLAUR FN1 PLAU FBN1 VCAM1 ITGB5 ITGAV INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis COL1A2 COL1A1 COL3A1 COL2A1 IGF1 VEGFA COL5A1 F11R COL4A1 PIK3R1 COL4A4 ROCK1 COL7A1 CDKN1B COL6A2 COL6A1 COL5A2 COL4A3 PIK3C2A COL4A6 ADGRA2 SDC1 ANGPTL3 COL4A5 COL6A3 MFGE8 FN1 PI4KA PI4KB CASP8 PIK3CA ITGB3 ILK SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 RHOA BCAR1 CBL VTN TGFBR2 RPS6KB1 IRS1 SRC PXN HSP90AA1 FGF2 PTPN11 IGF1R KDR PTK2 EDIL3 CSF1R TLN1 VCL CSF1 COL11A1 COL11A2 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III FHL2 TP53 EP300 BAX HDAC4 FOXO4 SIRT1 FOXO3 SIRT2 PPARGC1A SIRT3 XRCC6 FOXO1-1 KAT2B CREBBP ACSS2 CDKN1A TUBB2B;TUBB2A HOXA10 H1-4 ACSS1 MYOD1 MEF2D RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling MAPK3 RARA RARB PRKCG EP300 AKT1 NCOA1 NCOA2 NCOA3 HDAC3 MAPK14 KAT2B NRIP1 CCNH CDK7 RBP1 MNAT1 PRKACA-1 RXRB CDK1 RXRA HDAC1 NCOR2 RXRG PRKCA RARG MAPK8 CREBBP MAPK1 VDR HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha TP53 NAA10 CDKN2A CUL2 ARNT HIF3A RBX1 HSP90AA1 OS9 ELOC-1 COPS5 ELOB VHL HIF1AN EGLN1 EGLN3 EGLN2 RACK1 HIF1A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network SP1 COL18A1 NKX3-1 EP300 DSCAM NCOA3 AP1B1 CDKN1B VTN TFF1 PRDM15 AR NRIP1 KLK3;KLK2 NDUFV3 ATP5PF XBP1 CEBPB JUN SERPINA1 POU2F1 CYP2C18-1 SOD1 C4BPB SFTPD BRCA1 GCG FOS NR2F2 PISD NFIA NFIB FOXA1 NFIC SCGB1A1 FOXA3 FOXA2 APOB CREBBP ESR1 SHH INS;INS-IGF2 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway RHOA CAMK2A YES1 TAB2 CSNK1A1 TAB1 ROCK1 ARRB2 PPARG MAPK9 PRKCZ CTHRC1 MAP3K7 FZD2 FZD5 NFATC2 MAPK10 FZD7 DVL1 DVL2 FZD6 DVL3 WNT5A CHD7 FLNA SETDB1 CDC42 DAAM1 MAPK8 ROR2 NLK RAC1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAO1 GNAZ GNG2 GNAI2 NOS3 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 IGF1 BCAR1 PLCB1 PIK3R1 GNA13 GNA14 GNA15 GNA11 GNAQ PLCB2 SRC PIK3CA NRAS HRAS ESR2 PELP1 MSN MAPK11 IGF1R KRAS ROCK2 HBEGF GNAL GRB2 STRN SOS1 GNAI3 SHC1-1 GNAI1 ESR1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription APC CDKN2A ID2-1 YWHAE TCF7L2 YWHAB VCAN CCND1 YWHAQ CXCL8 SFN YWHAG YWHAH SNAI2 YWHAZ CAMK4 RUVBL2 TLE1 JUN XPO1 TBXT DVL3 INCENP TCF7L1 ZCCHC12 CHD8 CBY1 FGF4 MED12 SALL4 PITX2 TLE4 MYOG TLE2 MYC KRT1 CTNNBIP1 EP300 MMP2 TLE5 MMP9 DKK4 MDFIC MITF TBL1XR1 TNIK TCF7 ADCY7 NCOA2 CACNA1G IGF2BP1 HBP1 CDX4 BTRC CDX1 AXIN2 KCNIP4 KLF4 SMARCA4 BCL9 SP5 TRRAP NEUROG1 MYF5 TCF4 AR CCND2 HDAC2 TERT HDAC1 CDH1 CCN1 CTBP1 CUL1 SKP1 DKK1 CTNNB1 LEF1 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway EPO PIK3R1 CBL PLCG1 SOCS3 INPP5D SH2B3 EPOR JAK2 LYN STAT5B TEC STAT5A MAPK14 STAT1 NFKB1 PTPN6 PLCG2 BCL2L1 IRS2 RAP1A HRAS GAB1 BCL2 PTPN11 BTK CRKL RAPGEF1 MAPK8 GRB2 SOS1 VAV2 SHC1-1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway MAP3K1 TXN TRAF2 MAP3K3 TRAF6 CCM2 TAB2 TAB1 GADD45B GADD45G MAP3K6 MAPK14 MAP3K4 TAOK3 TAOK1 TAOK2 CAMK2B MAP3K10 MAP3K5 MAP3K7 MAP2K6 MAP2K3 CALM3;CALM1 MAPK11 GADD45A RAC1 ATM C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway PPP2CB;PPP2CA SKP2 MYC CDKN2A GSK3B HBP1 PAK2 RUVBL1 TRRAP KAT2A PML ACTL6A KAT5 RUVBL2 SUPT3H PIN1 SUPT7L MAX TAF9 AXIN1 TAF12 ZBTB17 TAF10 FBXW7 PPP2R5A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway MAPK3 GNAO1 GNAZ GNAI2 RHOA VEGFA PLCG1 KDR ABCC1 PDGFRB SPHK1 PTGS2-2 S1PR1 PDGFB GNAI3 MAPK1 GNAI1 PLCB2 RAC1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network FLT1 APP FYN VEGFA BLK YES1 TGFBR1-1 LAMA1 TGFB1 TGFB3 LYN FGR HCK TGFBR2 SERPINC1 PLA2G2A-1 SLIT2 PRNP TDGF1 SRC LCK FGF2 SMAD2;SMAD3 FGFR1 GPC1 NRG1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins MAP2K2;MAP2K1 EDN1 COL1A2 GNAO1 GNAZ GNA12 MMP1 GNAI2 COL3A1 GNA14 JAK2 PRKCD GNA15 GNA11 GNAQ JUN FOS PRKCB PRKCE CDC42 MAPK8 GNAL MAPK1 PTK2B RAC1 MAPK3 PRKCG TRPC6 AKT1 PLA2G4A RHOA PLCB3 BCAR1 PLCB1 ADCY7 MAPK14 PLCB2 SLC9A1 EDNRA SRC CYSLTR1 CYSLTR2 EDNRB PRKCH HRAS EDN2 EDN3 ADCY9 ADCY4 ADCY3 ADCY2 PRKCA ADCY1 ADCY8 ADCY6 ADCY5 SLC9A3 RAF1 CRK GNAI3 PRKCQ GNAI1 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network KDR VEGFC VEGFD NRP1 NRP2 FLT1 FLT4 VEGFB PGF VEGFA NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte TRPC6 AKT1 WASL PRKCI FYN PIK3R1 ARRB2 PLCG1 NCK2 BAD MAPK9 PIK3CB PRKCZ PARD6A PIK3CA JUN NCK1 TJP1 MAPK10 MAPK8 KIRREL1 GRB2 CD2AP NPHS1 F2RL2 NPHS2 RAC1 MAP2K4 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events LPAR4 GNAO1 GNAZ GNA12 GNAI2 GSK3B PIK3R1 TRIP6 CXCL8 RELA PLCG1 GNA14 PRKCD GNA15 GNA11 GNAQ SLC9A3R2 NFKB1 PIK3CB NFKBIA CASP3 JUN FOS PRKCE TIAM1 HBEGF MAPT PTK2B RAC1 GNG2 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 ARHGEF1 BCAR1 ADCY7 PLD2 GNA13 LYN SRC PXN HRAS ADCY9 GAB1 ADCY4 ADCY3 ADCY2 PRKD1 ADCY1 ADCY8 ADCY6 PTK2 ADCY5 CRK ADRA1B GNAI3 LPAR1 GNAI1 LPAR2 EGFR LPAR3 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions NPNT COL1A2 NID1 CSPG4 COL1A1 COL3A1 COL2A1 LAMB3 LAMA2 VEGFA COL5A1 COL4A1 LAMB2 LAMC2 FGB FGA COL4A4 LAMB1 COL7A1 COL6A2 COL6A1 LAMA1 COL5A2 TGFBI COL4A3 LAMA3 COL4A6 COL4A5 COL6A3 FN1 ITGA3 TNC F13A1 TGM2 ITGB1 ITGA4 ITGA2 ITGA1 PLAU ITGA10 SPP1 ITGA11 ITGA8 ITGA7 ITGA6 ITGAV ITGA5 LAMC1 ITGA9 COL18A1 IGSF8 VTN CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 FGG PLAUR FBN1 LAMA5 LAMA4 COL11A1 COL11A2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling ELANE FPR1 KLK4 VLDLR HGF FPR2 MMP9 PDGFD CTSG CTRC-2 BCAR1 MMP12 MMP13 FGB GPLD1 FGA VTN TGFB1 DOCK1 FN1 ITGA3 MMP3 FGG SRC ITGB1 ITGAM ITGB2 LRP1 PLG PDGFRB ITGB3 PLAUR PLAU CRK ITGB5 SERPINE1 EGFR ITGAV NCL-1 ITGA5 RAC1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CCL5 COL1A2 SP1 ID2-1 CCND1 GFI1 CLU CDKN1B FTH1 HMGCS2 TBP SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 ALDH9A1 GTF2H2C;GTF2H2C_2;GTF2H2 NDRG2 NDRG1 ZFP36L1 NFYB NFYC TMEM126A-1 S100A7A;S100A7 SFXN3 NFYA-1 TJP2 MXD4 ITGB1 DDIT3 ERBB2 LGALS1 ITGB4 DNTT CFLAR GADD45A IRF8 SPI1 CDKN1A ITGA6 MYC EP300 HDAC3 CREB1 RBL1 PTPA HDAC1 MAX BRCA1 FOXO3 BCL2 SMAD2;SMAD3 PDGFRB WNT5A ZBTB17 CDKN2B DKK1 CEBPA SMAD4 CEBPD ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network AREG EGF HSP90AA1 ERBB4 ERBB3 ERBB2 NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR TGFA NRG1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II NR3C1 GRK2 HDAC10 GNG2 HDAC11 YWHAE YWHAB GNB1 MEF2C HDAC5 HDAC3 GATA2 HDAC9 HDAC6 GATA1 HDAC7 CAMK4 TUBB2B;TUBB2A BCL6 SRF RFXANK NCOR2 HSP90AA1 BCOR ANKRA2 RANBP2 HDAC4 XPO1 UBE2I SUMO1 RANGAP1 RAN ESR1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 NEDD4L PDPK1 ZFYVE9 DACT2 RNF111 TGFBR3 ZFYVE16 STRAP PPP2R2A;PPP2R2D AXIN1 PPP1R15A TGFBRAP1 FKBP1A OCLN-1 YAP1-1 SPTBN1 SMURF2 DAB2 BAMBI DYNLRB1 WWP1 EIF2A PPP2CB;PPP2CA ITCH TGFBR1-1 ARRB2 TGFB1 TGFB3 CAV1 DAXX XIAP TGFBR2 SMURF1 PPP1CA RPS6KB1 PML PARD6A MAP3K7 SMAD2;SMAD3 CCN2 GRB2 SOS1 CTNNB1 SMAD4 SHC1-1 SMAD7 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions ITGB7 CDH1 ITGAE JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K1 LCP2 JUN MAP3K7 PRKCB LAT GRAP2 MAP4K1 CRKL MAPK8 DBNL CRK MAP3K8 MAP2K4 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ CSNK1A1 SFN YWHAG YWHAH BAD PRKCD YWHAZ CAMK4 MAP3K8 MEF2D MAPK9 AKAP5 PRKCZ CABIN1 PRKACA-1 CASP3 CHP1 NFATC3 NFATC2 XPO1 NFATC1 PRKCB CALM3;CALM1 PRKCE RAN FKBP1A RCAN1 MAPK8 RCAN2 KPNB1 KPNA2 NUP214 FKBP8 NR4A1 MAPK3 MAP3K1 PRKCG EP300 BAX MAPK14 CSNK2A1;CSNK2A3 BCL2L1 PIM1 PRKCH BCL2 PRKCA CREBBP PRKCQ TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells LCP2 PAG1 CSK TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 MAP4K1 PDPK1 CD86 MAP3K8 CD80 CD3G CD3D RASGRP2 IKBKB HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RASGRP1 CD4 CD28 ZAP70 HLA-DRA IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS FLNA PTPRC CDC42 DBNL SLA2 RASSF5 STIM1 ORAI1 WAS STK39 SH3BP2 FYB1 CHUK AKT1 MAP3K14 FYN CBL INPP5D PTPN6 PTEN RAP1A VAV1 HRAS GAB2 NCK1 LCK PTPN11 PRKCA GRB2 SOS1 ITK SHC1-1 PRKCQ VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals MAPK3 FLT1 NOS3 AKT1 VEGFA PIK3R1 SHC2 CBL PLCG1 CAV1 PDPK1 HIF1A PRKACA-1 PIK3CA HSP90AA1 NCK1 PRKCB PTPN11 CALM3;CALM1 PRKCA NRP1 NRP2 VEGFB RASA1 PGF CD2AP MAPK1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events EDN1 EDNRA EGF GRB2 SOS1 HRAS MTOR SHC1-1 EGFR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins MAP2K2;MAP2K1 SMO SIN3B GNAO1 GNAZ GNG2 SIN3A CSNK1G3 IFT172 GLI1 GNAI2 CSNK1D GLI3 AKT1 GSK3B STK36 KIF3A GNB1 CSNK1G2 RAB23 CSNK1G1 SPOP MTSS1 CSNK1A1 IFT88 ARRB2 BTRC TPTEP2-CSNK1E;CSNK1E FBXW11 SAP30 PRKCD HDAC2 PRKACA-1 LGALS3 HDAC1 XPO1 RBBP4 SAP18 RBBP7 PIAS1 FOXA2 PTCH1 CREBBP GNAI3 GNAI1 GLI2 SHH INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway SGK1-1 EIF4EBP1 AKT1 PTPN1 INSR PRKCI PIK3R1 SORBS1 CBL INPP5D NCK2 SH2B2 CAV1 PDPK1 TRIP10 RHOQ RPS6KB1 PTPRA AKT2 PRKCZ IRS1 PARD6A PIK3CA GRB10 HRAS NCK1 EXOC7 FOXO3 PTPN11 GRB14-1 DOK1 RAPGEF1 RASA1 EXOC4 EXOC3 GRB2 SOS1 EXOC6 CRK F2RL2 EXOC5 EXOC2 SHC1-1 INS;INS-IGF2 EXOC1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRB PDGFRA PDGFD PDGFA PDGFB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling VAV3 EPHA2 SRC PIK3CA RHOA PAK1 BCAR1 PIK3R1 CBL ARHGAP35 TIAM1 ACP1 PTK2 GRB2 VAV2 EFNA1 INPPL1 SHC1-1 RAC1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling MAP2K2;MAP2K1 EGF PIK3R1 STAT1 STAT3 MAPKAP1 PIK3CB MLST8 RICTOR PIK3CA CYFIP2 NCKAP1 WASF2 ABI1 CDC42 MAPK8 MAPK1 MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA MAP3K1 ARPC1B PPP2R1A ACTR2 PLD1 SMAD1 PLD2 ARPC4 ARPC5 BAIAP2 ARPC2 ARPC3 ACTR3-1 SRF SLC9A1 SRC HRAS GAB1 PRKCA GRB2 SOS1 F2RL2 CAPN2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 BAD PDPK1 PRKCD BRAF YWHAZ USP6NL ELK1 MAPK9 PRKCZ JUN DUSP1 NRAS PEBP1 FOS CALM3;CALM1 PPP2R2A;PPP2R2D KRAS RIN1 ATF2 VAV2 ATF1 RPS6KA4 RPS6KA5 AKT1 WASL MEF2C RAB5A ARF4-1 ZFP36 RALGDS MAP2K5 MYLPF PPP5C DIAPH3 DUSP6 MAPK7 MAP3K2 MTOR CREB1 BCL2L1 EPS8 CHN2 RPS6 RALA-1 RAF1 IQGAP1 EGFR LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE RHOA DYNLT1 MAP1B NUDC ABL1 LRP8 PLA2G7 RELN CSNK2A1;CSNK2A3 KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 CDK5R2 PAFAH1B2 CDK5R1 PAFAH1B1 CALM3;CALM1 LRPAP1 CDC42 PPP2R5D IQGAP1 CDK5 RAC1 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL MAPK3 RHOC SRC CCNA2-1 CDK2 RHOA RABGGTB AGT ITGB1 RABGGTA BCAR1 PTP4A2 PTP4A3 PTP4A1-1 ATF5 ROCK1 EGR1 ITGA1 CDKN1A CCNE1 MAPK1 RAC1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling PTPN13 FYN BLK PIK3R1 YES1 EFNB2 NCK2 EFNB1 LYN EPHB2 EPHB1 EPHB4 FGR HCK DNM1 SRC PIK3CA MAP3K7 LCK ITGA2B RGS3 TIAM1 ITGB3 MAPK8 RAC1 MAP2K4 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium MAPK3 COL1A2 AKT1 COL1A1 PIK3R1 FN1 MAPK14 CREB1 VEGFC VEGFD PIK3CA ITGB1 MAPK11 FLT4 ITGA4 RPS6KA1 ITGA2 ITGA1 GRB2 SOS1 CRK MAPK1 SHC1-1 ITGA5 MAP2K4 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events EPHA2 HGF EGF ARRB2 GNA14 GNA15 GNA11 GNAQ MET CYTH3 CYTH2 SRC PXN ADRB2 ADAP1 NCK1 ITGA2B TSHR KIF13B FBXO8 LHCGR IQSEC1 ACAP1 ARAP2 ITGB3 IPCEF1 AGTR1 GULP1 ACAP2 GIT1 EFNA1 ARF6 EGFR ARRB1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network AEN CCNE2 NDUFS2 HAGH NTRK1 SP1 PFDN5 PLPP1 FBXO45 CDK2 AFP GRAMD4 HSF1 CLCA2 BUB3 CDK6 BAK1 BCL2L11 DEDD GDF15 RB1 NSG1 ADA SFN TP53I3 RELA WT1 TP73 DCP1B BRCA2 NEDD4L ABL1 RACK1 CHEK1 GATA1 HEY2 KAT5 CCNA2-1 RCHY1 SERPINA1 WWOX MDM2-2 MAPK11 FAS YAP1-1 CDKN1A SERPINE1 JAK1 IL4R ITCH MYC TP63 PLK3 FASN EP300 BAX CCNB1 SIRT1 CASP2 BUB1 PRKACB-1 PLK1 MAPK14 JAG2 PML PIN1 CDK1 FOXO3 BIN1 IL1RAP BBC3 TUBA1A PEA15 RAD51 FLOT2 RNF43 S100A2 UBE4B CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 CXCL9 GNB1 CCL11 PIK3R1 CXCL13 CXCR3 PF4;PF4V1-1 PDPK1 CXCL10 CXCL11 MAPK14 MTOR DNM1 MAPKAP1 PIK3CB MLST8 RICTOR SRC PIK3CA NRAS HRAS MAP2K6 MAP2K3 MAPK11 KRAS RAF1 GNAI3 MAPK1 GNAI1 ARRB1 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events PIK3R1 CISH YWHAG CSF2RB INPP5D PRKACB-1 JAK2 STAT5B STAT5A SRP9 YWHAZ CNKSR1 IL3RA ID1 BCL2L1 PRKACA-1 PIK3CA CEBPB PIM1 HDAC1 GAB2 PTPN11 IL3 OSM GRB2 SHC1-1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNA12 GNAI2 NOS3 PRKG1 EGF ROCK1 GNA14 PRKCD GNA15 GNA11 GNAQ PTGDR PTGIR DNM1 TBXA2R SLC9A3R1 TGM2 PRKCZ PRKACA-1 PRKCB PRKCE MAPK11 SELE RAC1 GRK2 GRK3 GNG2 SYK PRKCG AKT1 RHOA GNB1 ARHGEF1 FYN BLK YES1 ARRB2 GNA13 LYN PIK3CG MAPK14 FGR PIK3R6 HCK VCAM1 PLCB2 ARR3 SRC PRKCH LCK GNB5 PRKCA ICAM1 RAB11A PRKCQ EGFR A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling IL1A MST1 YWHAE AKT1 EGF YWHAB LAMB3 LAMA2 PIK3R1 CASP7 LAMB2 LAMC2 YWHAQ LAMB1 SFN YWHAG LAMA1 YWHAH LAMA3 YWHAZ MET RPS6KB1 COL17A1 PMP22 CD9 PIK3CA RXRB RXRA CDH1 RXRG HRAS ITGB1 ERBB3 ERBB2 ITGB4 PRKCA MST1R GRB2 SHC1-1 LAMA5 LAMA4 ITGA6 EGFR LAMC1 RAC1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway MAP2K2;MAP2K1 SGK1-1 CDK2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH TSC2 PDPK1 YWHAZ BRAF YY1 MAPKAP1 PRR5 IKBKB RB1CC1 MLST8 TSC1 RICTOR ATG13 RRAGA RRAGC RRAGB RRAGD NRAS DDIT4 ULK2 ULK1 RRN3 POLDIP3 PPARGC1A EIF4B BNIP3 EEF2 RHEB PDCD4 RPTOR KRAS DEPTOR AKT1S1 RPS6KA1 EEF2K SREBF1 CYCS-1 MAPK1 MAPK3 EIF4EBP1 EIF4E AKT1 PLD1 BTRC PLD2 EIF4A1 FBXW11 MTOR RPS6KB1 PML CLIP1 IRS1 HRAS PRKCA RAF1 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway BTRC NFKB1 NFKB2 CHUK MAP3K14 RELB DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors SP1 AFP VCAN BAK1 GDF15 RB1 TP53I3 TP73 MAP4K4 CASP10 DDIT4 BID MDM2-2 FAS STEAP3 CCNK PRDM1 PYCARD SESN1 FDXR BNIP3L TAP1 SPP1 PRKAB1 HIC1 MSH2 CTSD TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 TP63 SH2D1A PLK3 TADA2B COL18A1 RGCC MMP2 CD82 JMY BCL2L2 BTG2 BAX CCNB1 PPP1R13B CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 DDB2 RNF144B SMARCA4 RRM2B CAV1 IRF5 TYRP1 TRRAP HTT RPS27L PPM1J NLRC4 TP53INP1 E2F2 DROSHA PMS2 TIGAR PML ARID3A MLH1 CEBPZ MCL1 PTEN POU4F1 POU4F2 EDN2 TAF9 PCNA PMAIP1 E2F3 HSPA1A;HSPA1B TGFA TP53 APC HGF SFN TSC2 SNAI2 MET NDRG1 NFYB NFYC NFYA-1 RCHY1 DUSP5 JUN DUSP1 SERPINB5 BCL2A1 CARM1 GADD45A PERP BDKRB2 IGFBP3 CDKN1A SERPINE1 EPHA2 EP300 PIDD1 CASP1 CSE1L APAF1 KAT2A TFDP1 BCL6 COP1 ATF3 BCL2L1 CASP6 CCNG1 HDAC2 E2F1 BCL2 FOXA1 LIF DKK1 CREBBP BBC3 VDR S100A2 EGFR LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events LPAR4 RPS6KA5 PRKACA-1 ADCY9 ADCY4 ADCY7 ADCY3 ADCY2 PRKCE ADCY1 ADCY8 ADCY6 ADCY5 GNAL CREB1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly CDH2 SNX1 GNA12 NTRK2 MMP7 PTPN1 EGF BDNF FYN HGS RAB5A ABL1 ADAM10 GNA13 MET PTPN6 RET MMP3 ROBO1 CTNND1 SLIT1 SRC DSP CASP3 IGF2 CABLES1 ZBTB33 CDH1 MEP1B CTNNA1 HRAS CBLL1 JUP GFRA1 TIAM1 IGF1R DNM2 RAB7A NME1 GDNF CDC42 RIN2 CREBBP CTNNB1 IQGAP1 ARF6 EGFR RAC1 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling TP53 BIRC5 TACC1 ARHGEF7 AURKA AKT1 GSK3B PAK1 FZR1 CDC25B AJUBA NDEL1 CKAP5 TPX2 NFKBIA PRKACA-1 TACC3 OAZ1 DLGAP5 TDRD7 BRCA1 CPEB1 AURKAIP1 MDM2-2 CENPA GADD45A RAN RASA1 AURKB GIT1 PPP2R5D CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling MAP3K1 MYC TRAF1 TRAF2 AKT1 TRAF6 MAP3K14 PIK3R1 RELA STAT5A PIK3CG MAPK14 PIK3R6 MAPK9 NFKB1 PIK3CB NFKBIA BCL2L1 PIK3CA JUN MAPK10 CD40 MAPK11 TNFAIP3 IL4 C4BPA FCAMR TRAF3 BIRC2 TDP2 CD40LG BIRC3 MAPK8 CBLB JAK3 MAP2K4 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network DDX54 SMARCA4 C3-1 SMARCB1 NR0B2 ESR2 SMARCE1 NCOA1 UBA3 NR0B1 NCOA2 NCOA3 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKA AURKC AURKB LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STK11IP TP53 STRADA STRADB ETV4 MYC STK26 SIK3 SIK2 YWHAE GSK3B YWHAB YWHAQ SFN YWHAG YWHAH TSC2 YWHAZ MTOR CREB1 MARK2 MLST8 TSC1 PRKACA-1 CDC37 HSP90AA1 EZR RPTOR AKT1S1 BRSK1 BRSK2 CRTC2 SMARCD3 CAB39 SMAD4 PSEN2 STK11 MAPT MAP2 CTSD ESR1 SIK1;SIK1B MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB2 EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway MAP2K2;MAP2K1 MAPK3 NTF3 RPS6KA5 RUSC1 MAPKAPK2 MEF2C RAP1B EGR1 MAP2K5 PRKCD RIT1 TRPV1 MAPK14 RIT2 MAPK7 BRAF EHD4 ELK1 MAP3K2 CREB1 SRF RAP1A CDK5R1 NRAS HRAS MAP2K6 MAP2K3 FOS KRAS RPS6KA1 RAF1 MAPK1 CDK5 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway MAP3K1 TRAF1 TXN CHUK TRAF2 TNFRSF1A NRK MAP3K3 MADD MAP4K5 RFFL PRKCI TNIK NSMAF MAP4K3 MAP4K2 TAB2 TNFRSF1B TAB1 SQSTM1 TNF CYLD RELA CAV1 RACK1 STAT1 MAP4K4 SMPD2 NFKB1 PRKCZ IKBKB CASP8 MAP3K5 SMPD1 RIPK1 FADD IKBKG MAP3K7 MAP2K7 MAP2K3 TNFAIP3 ADAM17 BIRC2 TRADD BIRC3 BAG4 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks NR3C1 SP1 HNF4A AFP AKT1 ACADVL ALAS1 G6PC1 TAT SLC2A2 HMGCS1-1 TTR TFRC UCP2 NKX2-1 ACADM HADH PCK1 IGFBP1 CPT1A CREB1 KCNJ11 PKLR ABCC8 FOXF1 PDX1 APOA1 DLK1 HNF1A CPT1C CPT1B CEBPB GCK BDH1 ALB ALDOB F2 FOXA1 NF1 FOXA3 FOXA2 CEBPA CEBPD INS;INS-IGF2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events APC ARHGEF7 ARHGEF6 GSK3B PIK3R1 BRAF RASGRF1 MAPK9 PRKCZ PIK3CA JUN PAX6 MAP2K7 HES5 MAP2K6 SEPTIN2 TNK2 CDC42BPA ENAH PRKCE TIAM1 DLG1 CDC42 MAPK8 ATF2 VAV2 PAK4 MAPK1 RAC1 MAP2K4 MAPK3 MAP3K1 ARPC1B WASL PAK1 BCAR1 ARHGDIA ACTR2 YES1 PLD1 CBL IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 DIAPH3 ARPC3 MAPK14 ACTR3-1 MTOR MAP3K11 RPS6KB1 EPS8 SRC PARD6A CFL1 CDH1 HRAS CTNNA1 MAP2K3 EXOC7 LIMK2 LIMK1 MYL2 RAF1 CTNNB1 F2RL2 IQGAP1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events PAG1 GNAO1 GNAZ GNAI2 CSK CXCR4 RALB PIK3R1 CD3E RAP1B RACK1 BAD JAK2 PDPK1 STAT5A STAT1 STAT2 STAT3 DNM1 CD3G MAPKAP1 CD3D PIK3CB MLST8 PRKCZ HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RHOC RICTOR CD4 RHOB PIK3CA HLA-DRA CD247 RGS1 VPS4B VPS4A GRK6 UBQLN1 PTPRC CDC42 SSH1 PTK2B RAC1 GRK2 GNG2 ITCH AKT1 MMP9 RHOA PLCB3 PAK1 GNB1 BCAR1 PLCB1 FYN BLK YES1 ARRB2 HGS CXCL12 INPP5D FOXO1-1 GNA13 LYN STAT5B PIK3CG FGR PIK3R6 HCK MTOR PLCB2 ARR3 PTPN6 SRC CFL1 PXN VAV1 LCK LIMK1 PTPN11 PTK2 CRK GNAI3 GNAI1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases SRF YWHAE YWHAB MAPKAPK3 YWHAQ MAPKAPK2 MAPK11 SFN YWHAG YWHAH ETV1 LSP1 TSC2 MAPK14 YWHAZ RAF1 CREB1 TH CDC25B HSPB1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling WNT1 MAPK3 APC PPARD MYC TLE5 GSK3B CCND1 CSNK1A1 TAB1 BTRC NOTCH1 ADAM10 FBXW11 RBPJ DTX1 DLL1 CSNK2A1;CSNK2A3 LRP6 HNF1A WIF1 TLE1 HDAC1 JUN FZD1 CTBP1 MAP3K7 FOS DVL1 AXIN1 PSENEN PSEN1 NKD1 NEDD4 DKK2 APH1A KREMEN2 CREBBP DKK1 CTNNB1 NCSTN APH1B MAPK1 PPP2R5D NLK VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms AEN SP1 CDKN2A CLCA2 YWHAQ GDF15 ADA TP53I3 ABL1 PRKCD MFGE8 ITGA3 IKBKB SERPINB5 ITGB4 MDM2-2 GADD45A FAS PERP OGG1 NOC2L FDXR DST DICER1 CDKN1A IGFBP3 TRAF4 SPATA18 EVPL WWP1 SHH NQO1 TFAP2C SSRP1 DHRS3 ITCH TP63 CHUK EP300 BAX HBP1 BTRC EGR2 PLK1 JAG1 PML CABLES1 PMAIP1 BBC3 SMARCD3 FLOT2 VDR S100A2 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway MAP2K2;MAP2K1 JAK1 MAPK3 MAP3K1 PTGES2 IRF9 DAPK1-1 EP300 AKT1 CAMK2A PIAS4 PIK3R1 CAMK2D CBL CASP1 SOCS1 RAP1B PTPN2 JAK2 PRKCD STAT1 MTOR MAP3K11 STAT3 CAMK2B PIK3CA CEBPB IRF1 IL1B RAP1A PTPN11 CALM3;CALM1 CAMK2G CRKL PIAS1 RAPGEF1 IFNGR1 IFNG CREBBP MAPK1 SMAD7 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway CD4 KDELR1 GOSR2 USO1 ASAP1 GBF1 CLTB AP2A1 ARFGAP1 GGA3 ARFIP2 AP2M1 PLD2 ARF1 COPA PIP5K1A CLTA CYTH2 RAC1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events IL1A UBE2N CHUK IRAK4 MAP3K3 TRAF6 PRKCI IL1R1 PIK3R1 TAB2 IRAK1 TAB1 SQSTM1 IL1RN ERC1 RELA CASP1 TICAM2 IL1R2 IRAK3 MYD88 TOLLIP UBE2V1 NFKB1 PRKCZ IKBKB PIK3CA IL1B JUN IKBKG MAP3K7 MAP2K6 IL1RAP MAPK8 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network TP53 IL5 SGK1-1 CSN2-1 MMP1 AFP GSK3B CXCL8 SFN RELA YWHAH TBP EGR1 STAT5A STAT1 SMARCC1 CSF2 MAPK9 NFKB1 TBX21 IL13 IL6 PRKACA-1 IRF1 JUN POU2F1 NFATC1 FOS MAPK10 MDM2-2 IL2 MAPK11 IL4 SELE IFNG KRT16;KRT14 MAPK8 POMC SPI1 CDKN1A MAPK1 CDK5 NR4A1 NR3C1 KRT5 MAPK3 EP300 AKT1 BAX NCOA1 NCOA2 FKBP4 SMARCA4 VIPR1 SUMO2 PRKACB-1 STAT5B PPP5C KMT5B POU1F1 MAPK14 SMARCC2 FKBP5 CREB1 SMARCD1 TSG101 NR1I3 CGA PCK2 PBX1 KRT17 FGG HDAC2 HDAC1 CDK5R1 HSP90AA1 GATA3 ICAM1 CREBBP PRL INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 ARHGEF7 EGF PIK3R1 SPRY2 CBL HGS ITSN1 RAB5A UBE2D1 TSG101 DNM1 SYNJ1 PIK3CB UBE2D3;UBE2D2 EPN1 SRC PIK3CA CHMP3 AMPH STAMBP NRAS HRAS SH3GL2 LRIG1 USP8 UBE2D3-1 PTK2 SH3KBP1 KRAS CDC42 GRB2 SOS1 RAF1 EPS15 SHC1-1 CBLB EGFR E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network CCNE2 SP1 CDKN2A XRCC1 CDK2 SMARCA2 RBL2 RB1 CDKN1B TP73 YY1 RBBP8 CCNA2-1 CBX5 PLAU CDKN1A HIC1 SERPINE1 CCND3 MYC WASF1-1 EP300 PRMT5 CASP7 SIRT1 HBP1 TFE3 APAF1 TRRAP KAT2B KAT2A E2F2 RBL1 TFDP1 TK1 TRIM28 E2F4-1 MCL1 CDC25A CDK1 UXT HDAC1 E2F1 MYBL2 DHFR2;DHFR CDC6 TFDP2 MCM3 SULT2A1-4 BRCA1 RRM2-1 CES3 RBBP4 CES2 TOPBP1 CES1 TYMS CES5A ORC1 E2F5 E2F6 E2F3 E2F7 RANBP1 RRM1 CDKN2C CEBPA CREBBP POLA1 RYBP CCNE1 ATM CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NFKB1 NFKBIA IKBKB CHUK TNFRSF1A IKBKG TRAF6 XPO1 BCL10 TNF UBE2D3-1 CYLD PRKCA MALT1 ERC1 TNFAIP3 RELA BTRC RAN BIRC2 NOD2 RIPK2 ATM EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EFNA5 EPHA5 FYN TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CD8B;CD8B2 LCP2 PAG1 CSK HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 PDPK1 CD86 MAP3K8 CD80 PRF1 CD3G CD3D RASGRP2 IKBKB RASGRP1 CD28 ZAP70 IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS PTPRC RASSF5 STIM1 ORAI1 CHUK AKT1 MAP3K14 FYN CBL PTPN6 RAP1A VAV1 HRAS LCK PRKCA B2M GRB2 SOS1 CD8A SHC1-1 PRKCQ REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase DKC1 POT1 TERF2 TERF2IP PIF1 SP1 PTGES3-1 SP3 TNKS WRN YWHAE ACD EGF ZNFX1 HNRNPC TERF1-1 CCND1 BLM CDKN1B WT1 ABL1 NFKB1 HUS1 IRF1 JUN RAD1 RAD9A FOS NR2F2 IL2 IFNG MAPK1 NCL-1 MAPK3 UBE3A SIN3B SIN3A MYC SMG5 AKT1 TGFB1 SAP30 MTOR RPS6KB1 MXD1 HDAC2 TERT HDAC1 E2F1 HSP90AA1 MAX MRE11 RBBP4 NBN SMAD2;SMAD3 SAP18 RBBP7 XRCC6 XRCC5 IFNAR2 RAD50 PINX1 SMG6 ESR1 PARP2 EGFR TINF2 ATM REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein SKP2 ELF1 CDK4 CBX4 CDKN2A CDK2 CDK6 SUV39H1 AATF CCND1 BRD2 RB1 PAX3 RBP2 CDKN1B DNMT1 CKM TBP PPP2R3B ATF7;ATF7-NPFF ABL1 TAF1 MET CSF2 MAPK9 CCNA2-1 JUN SFTPD TGFB2 MDM2-2 MAPK11 ATF2 SPI1 CDKN1A PPP2CB;PPP2CA CCND3 EP300 MITF SIRT1 MEF2C PPARG HDAC3 SMARCA4 RUNX2 MAPK14 CCND2 E2F2 UBTF TFDP1 MYOD1 E2F4-1 CEBPB HDAC1 E2F1 CTBP1 RBBP4 GSC SMARCB1 E2F3 RAF1 CEBPA CREBBP CEBPD CCNE1 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling MAPK3 MAP3K1 CTDSP1 PIAS4 CTDSP2 UBE2I CALM3;CALM1 SMAD2;SMAD3 TGFBRAP1 CTDSPL NUP153 PPM1A KPNB1 SMAD4 KPNA2 NUP214 MAPK1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network EDN1 SP1 ID2-1 CITED2 EPO SLC2A1 CXCR4 PGK1 VEGFA COPS5 LEP EGLN1 EGLN3 BHLHE40 BHLHE41 NOS2 RORA ABCG2 ADM IGFBP1 HIF1A HK2 FURIN HK1 NDRG1 CA9 TF PGM1 PKM PLIN2 ALDOA PFKFB3 ABCB1 FECH NT5E GCK ARNT CP JUN PFKL ITGB2 FOS BNIP3 NPM1-2 ETS1 SERPINE1 HNF4A EP300 AKT1 NCOA1 NCOA2 CXCL12 TFF3-1 GATA2 TFRC ENO1 HDAC7 CREB1 ENG MCL1 TERT SMAD2;SMAD3 LDHA HMOX1 CREBBP SMAD4 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR AKT1 GSK3B FYN PIK3R1 CBL MAP1B NCK2 ITGA3 MAP3K11 LRP8 RELN DAB1 PIK3CA RAP1A CDK5R1 GRIN2A PAFAH1B1 MAPK8IP1 ITGB1 MAP2K7 ARHGEF2 GRIN2B CRKL RAPGEF1 LRPAP1 MAPK8 MAPT CDK5 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway MAPK3 PIK3CB MAP3K1 IKBKB CASP8 PIK3CA CASP10 CHUK TRAF2 SMPD1 RIPK1 FADD IKBKG TNFSF10 DAP3 PIK3R1 CFLAR TRADD MAPK8 MAPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MAP2K4 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling MAPK9 GNG2 MAPK8 GNAL MAPK14 GNB1 CRH MAPK11 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP JAK1 ATR EIF2AK2 HGF PTPN1 EGF INSR VEGFA PIK3R1 STAT6 PTPN2 STAT5B STAT5A STAT1 STAT3 MET RAB4A PIK3CB SRC PIK3CA ITGB1 GAB1 LMAN1 KDR PDGFRB PIAS1 ITGA1 CSF1R GRB2 CREBBP SOS1 KPNB1 KPNA2 PDGFB CSF1 SHC1-1 EGFR JAK3 EIF2A INS;INS-IGF2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GSK3B CTDSP1 CTDSP2 TAB2 BMPR2 TAB1 SMAD1 CTDSPL SMAD9 PPM1A SMAD5 BMP4 XIAP SMURF1 PPP1CA MAP3K7 CHRD ZFYVE16 CHRDL1 HJV PPP1R15A SOSTDC1 CER1 AHSG FST SMURF2 NOG RGMB SMAD6 BAMBI BMP6 RGMA SMAD4 GREM1 NUP214 BMP2 MAPK1 BMPR1A BMP7 SMAD7 SKI PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 RHOA GNB1 F2 ROCK1 ROCK2 GNA13 GNA14 MYL2 GNA15 GNA11 GNAQ F2RL2 F2RL3 PLCB2 FSH%NETPATH%FSH FSH MAP2K2;MAP2K1 GRK4 AKT2 FSHB FSHR GRK6 CGA APPL1 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog ARRB2 GLI1 GLI2 MED12 PRKACA-1 CCNB1 GRK2 STK36 BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 CTNNB1 GAS1 YWHAE DHH HHIP IHH ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor AR CREB1 HDAC1 HSPB1 AKT1 PIK3R1 PTK2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor HNF4A NCOA1 MAP4K1 PDPK1 FOXO1-1 FOS PJA1 TGFBR2 NME1 TGFBR3 RBL2 PPM1A KAT2B ZEB2 ZEB1 TFDP1 TFDP2 PIK3CA CRK CD44 ENG PPP1R15A FZR1 PARD6A STAMBPL1 YAP1-1 CTNNA1 SIK1;SIK1B MAPK1 CTNNA2 SAMD3 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 PML SKI FKBP1A EIF3I FOSB BCAR1 TRIM33 ARRB2 AR HDAC1 AKT1 PIK3R1 PTK2 RB1 ATF2 SPARC ZFYVE9 UBE2D1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC SNIP1 SOX9 BTRC JUNB VPS39 SKP1 PDK1 NUP214 MAP2K3 MEF2A DAXX MEF2C ANAPC7 RUNX3 CDC25A RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B CCNE1 EWSR1 ANAPC4 ANAPC5 TP53 PPP2R2A;PPP2R2D ANAPC1 ATF3 KPNB1 ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SPTBN1 SNX6 MAP2K6 TRAP1 WWTR1 HSPA8 TGFB2 JUN SMAD4 JUND TGFB1 UBE2I SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 DAB2 SNW1 CDK6 COPS5 SP1 CDK4 CDC16 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 GSK3B CDKN1A CITED1 BRCA1 CTCF UBE2D3-1 ING2 XPO1 XPO4 SUMO1 TCR%NETPATH%TCR TCR SHC1-1 MAP2K2;MAP2K1 DYRK1A CTNNB1 CREB1 AKT1 PIK3R1 PTK2 ATF2 PXN PIK3R2 GSK3B CRK MAPK1 MAPK3 ITSN2 CYFIP1 TFRC WIPF1 CBLB ENO2 CRKL GOLGA5 UBASH3B DPYSL2 TRIM25 HOMER3 PRKCD CD2AP PARD3 PRKD2 PRKD1 EPHA3 SKAP1 TXK PTTG1IP BCL10 LY9 LDHB LDHA INPP5D PLCG2 SLAMF6 PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 NFATC2 LNPEP NFATC1 CGN EPRS1 CD28 UNC119 GRB2 GRAP CALM1 ADA ITK MTMR10 CLTC GDI2 CD3G PTPRH SHB CD3E CD3D IKBKB PPP3CB TUBA1A CTLA4 JAK3 VAV3 DUSP3 DBNL ANXA2 SYK RIPK2 FCRL3 NFAM1 PGAM1 GAB2 ZDHHC17 VAV1 VAV2 ENAH BDH1 RAPGEF1 ARHGEF2 HNRNPH3 ARHGEF7 ARHGEF6 AHCY WAS NEDD9 RELA PAK1 FLNB CCT8 MPZL1 DDX3X-1 GIT2 STAT1 ERBIN ELP3 DEF6 ACTR10 CD86 CD84 CD82 CD80 DGKA SLA ARHGAP35 SIT1 GRAP2 ARHGDIB MAP3K8 G6PD KIRREL1 ANXA11 SKAP2-2 DYRK1B PRPF4B LAX1 TUBA4A DOK1 ACLY DOK2 HGS ELMO1 ADAM9 PKP4 RAF1 STAM2 CARD11 KHDRBS1 TSG101 STK39 ITPR1 RASGRP2 STK4 RASGRP1 SDCBP RAP1A CASKIN2 ABL1 LPXN BMF ACBD6 NFKB1 NFKBIA DIAPH1 NCL-1 FER PTPRC PTPRA TUBB4A;TUBB;TUBB8B;TUBB8 OGN CDK1 PI4KA LAT NFKBIB HSP90AB1 DDX49 WDR1 PTPN22 CABIN1 PIK3C2B PSTPIP1 YWHAQ SNRNP70 ZNF404 ACP1 PGM1 NCK1 CHUK SH2D3C MSL2 YWHAZ DNM2 ACTA1 ZAP70 PKM LCK RASA1 PECAM1 C9orf78 LCP2 EVL DOCK2 SOS1 SOS2 R3HCC1L CEBPB SRC ATP1A3 ATP1A1 CBL HDAC7 DNAJB1 MUC1 MAPK8 MAPK7 SH3BP2 PTK2B SH2B3 TRAT1 TXNRD1 PTPN11 PTPN12 MAPK14 CD2 MAPK11 CD4 EIF3M TEC RPS6KB1 CD5 CD7 PTPN6 PIK3AP1 RAN PTPN3 LEPTIN%NETPATH%LEPTIN Leptin SHC1-1 CRP NCOA1 PRKAA1 GSK3A PRKAA2 ITGB5 PLCG2 IRS1 STAT1 IRS4 PLCG1 SLC2A4 ACACB EGFR IGF1R RPS6KA2 CFL2 ERBB2 EIF4EBP1 FYN CHUK EIF4E SOCS7 JAK1 SH2B1 NOS3 PRKCE GRB2 RPS6 LIMK1 AKT1 CDK5 GNAQ PTK2 LEP MAPK1 PDE3A SRC IKBKB JAK3 KHDRBS1 ESR1 MAPK8 GSK3B RUNX2 NFKBIA RPS6KB1 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor STAT1 EIF4EBP1 FYN PIK3CA CRK RPS6 AKT1 PIK3R1 MAPK1 PTPRU ATF2 SH3KBP1 SPRED2 GYS1 SPRED1 RPS6KA1 EP300 JAK2 HRAS RAF1 PRKCB MATK PRKCA MITF FGR HCK KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A WIPF1 EZR CBLB GRB7 CSF2RB CRKL SOCS1 ABL1 SOCS6 SOCS4 SOCS5 STAT5A STAT5B YES1 RDX MSN MTOR EPOR MAPK12 KITLG FES CDK2 IL7R MAD2L1 INPP5D GRAP RASA1 JUN CLTC SOS1 SRC JAK3 MAPK8 PTPN11 MAPK14 GSK3B TEC RPS6KB1 WAS RELA BCR%NETPATH%BCR BCR SHC1-1 MAP4K1 GSK3A PDPK1 FOS EIF4EBP1 FYN CRK RPS6 MAPK1 RPS6KA1 PRKCB FOSB BCAR1 HCK CRKL PRKCD PRKD1 CDK2 BCL10 SLA2 ELK1 TCL1A PIP4K2A PIP4K2B PIP4K2C PLCG1 GTF2I MAPKAPK2 BTK LYN IFITM3;IFITM2;IFITM1 PRKCQ CCL3L1;CCL3L3;CCL3;CCL18 ITPR2 RASGRP3 NFATC2 CD79B CD79A BTLA CHST15 STAP1 PIP5K1A PIP5K1B GRB2 PIP5K1C NFATC3 CDK7 HNRNPK ITK BCL6 CD22 PIK3CG CASP9 CASP7 BLNK LAT2 BANK1 IKBKB HCLS1 MALT1 CYCS-1 CCL4L2;CCL4L1;CCL4 SH2B2 PTPN18 CD72 PLEKHA1 PLEKHA2 STAT3 BAX VAV1 RAPGEF1 NEDD9 RELA STAT1 CTNNB1 CREB1 AKT1 PTK2 RB1 ATF2 DOK1 CARD11 JUNB ITPR1 PIK3R2 FOXO3 NCK1 CHUK ZAP70 LCK RASA1 JUN SOS1 SOS2 SH3BP2 MAPK14 GSK3B TEC RPS6KB1 PTPN6 TNFALPHA%NETPATH%TNFALPHA TNFalpha IRS1 EGFR EP300 PRKCA STAT5A GTF2I MAPKAPK2 CASP7 BAX RPL4 RPL30 SMARCB1 RPL8 RPL6 DCAF7 PSMD6 TBK1 PSMD7 AKT2 RPS6KA5 PSMD2 PSMD3 DPF2 PSMD1 RPS11 YWHAE RPS13 SMARCC1 SMARCC2 PSMC2-1 CDC34 CDC37 KCNQ1 TXNIP TRIB3 TXN IQGAP2 GLG1 FADD CRADD SMARCA4 REL FAF1 SMPD3 NKIRAS1 CASP10 NKIRAS2 RFK RACK1 IKBKG IKBKE RIPK3 CREB1 ACTL6A HDAC1 GAB1 HSPB1 AKT1 COMMD1 TAX1BP1 PTK2 CSNK2A1;CSNK2A3 RB1 AKAP8 XIAP TANK RELB PSMB5 RXRA FLNA BID MAP3K2 MAP3K3 ELP1 DIABLO-1 LRPPRC KTN1 BTRC ITCH JUNB PSMC3 PSMC1 SKP1 PKN1 PDK1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 KPNA2 KPNA3 MAP3K5 UNC5CL FBXW11 FBXW7 USP2 CYBA TRPC4AP TXLNA FANCD2 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A RASAL2 BAG4 BRINP1 CUL1 NLRP4 G3BP2 MAP2K5 MARK2 ZBTB17 MCC CDK9 COPS3 BCL3 ALPL TAB3 TAB2 MAP2K6 NFKBIE TRAP1 MAP3K11 BCL2L1 RNF11 MCM7 JUN YWHAB PPP6C BCL7A PPP1R13L UBE2I CASP3 NFKBIZ CASP2 YWHAG YWHAH CAV1 HSP90AA1 PPP1R12A PEG3 TNFRSF1B TRAF7 RASA3 TRAF4 POLR1A POLR1B TRAF6 POLR1C TRAF5 POLR1D POLR1E MCM5 TAB1 PFDN2 BIRC2 BIRC3 HDAC2 USP11 MTIF2 NR2C2 HDAC6 UBE2D3-1 MAPK9 ERBB3 TIFA ROMO1 SUMO1 POLR2H RFFL POLR2L SMARCE1 SPAG9 FOXO1-1 RNF25 CFLAR GLB1 TNIP2 PRC1 PDCD2 TBKBP1 TRIM32 MAPK1 MAPK3 UBE2D3;UBE2D2 PML CREBBP GRB2 PAK1 DDX3X-1 STAT1 MAP3K8 DOK1 NFKB1 NFKBIA HSP90AB1 YWHAQ YWHAZ SOS1 SOS2 SRC MAPK8 PTPN11 MAPK14 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin PAK1 SHC1-1 FOS IRS1 ERBIN EGFR RTKN ITGB4 PIK3CD ERBB2 LAMC2 EIF4EBP1 IRS2 FYN LAMC1 PIK3CA EIF4E PIK3CB MYLK3 RAC1 EPHB2 AR DSP DST GAB1 RPSA AKT1 RHOA ITGA6 PIK3R1 MET PTK2 PLEC MAPK1 COL17A1 LAMA5 CD151 MAPK3 LAMA2 LAMA3 PIK3R3 MST1R NTN1 SMAD2;SMAD3 CLCA1 SFN PRKCA LAMB3 BAD LAMB2 LAMB1 EIF6 VIM ABL1 PRKCD YES1 MTOR YWHAQ PIK3R2 YWHAZ GRB2 YWHAB JUN PIK3CG CASP3 YWHAH SRC PTPN11 MAPK14 TP73 YWHAE WNT%NETPATH%WNT Wnt ARRB2 PRKACA-1 RAC1 AKT1 RHOA CCND1 PRKCB PRKCA PPP2CB;PPP2CA CHD7 DIXDC1 SOX1 CDH1 MAP3K7 PRKCG WNT5A AXIN1 PRKCD KREMEN1 YES1 DKK1 PAX2 SFRP1 SFRP2 DAAM1 ARHGEF4 ROR1 PI4K2A LRP1 CTBP1 LEF1 LRP5 NLK MESD FRZB GPC3 DVL3 WNT1 WNT2 WNT3 FZD1 MARK2 SMAD1 TCF7L2 JUP NFATC2 FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD6 PIP5K1B FZD9 PPP1CA BCL9 PIN1 TCF4 YWHAB JUN MAPK8 CDK6 IL6%NETPATH%IL6 IL6 SHC1-1 NCOA1 FOXO1-1 FOS STAT1 ERBB2 EIF4EBP1 FYN EIF4E JAK1 RAC1 AR HDAC1 HSPB1 GAB1 AKT1 PIK3R1 RB1 MAPK1 MAPK3 EP300 BAD FGR HCK DAXX MAP3K7 STAT5A STAT5B NFKB1 PRKCD NLK PLCG1 BTK LYN PIK3R2 FOXO4 FOXO3 CREBBP CDK9 MAP2K6 GRB2 CD40 JUN SGK1-1 IL6R MAP3K4 EIF2A PIAS3 MAP2K4 TYK2 HNRNPA1-1 HSP90AA1 IL6ST SOCS3 CBL BMX IL6 MAPK8 STAT3 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 GSK3B RPS6KB1 ERBB3 TSH%NETPATH%TSH TSH IKBKB ATP1A1 RAF1 HSPA5 CALR-1 GNAI3 SCRIB IGF1R TSHR GNAI1 GNAS-1 GNAI2 MAP2K3 GNAO1 GNA13 GNA11 CANX GNA12 CREB1 MAP2K6 GNAQ LEP MAPK3 EGFR1%NETPATH%EGFR1 EGFR1 EPHB1 EPHB4 TNS2 TNS1 EPHB3 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 PFN1 TLN1 RIN1 EPHA1 EPHA2 SDC4 ASAP3-1 SDC3 MYL12B RACGAP1 RALGDS SNX5 INSR STAM SMU1 SPART SDC1 CC2D1A PTPRR HIP1 AP2A1 PTPRK WASL LIMD1 PTPRF OTUD6B GIT1 NCOA3 RALBP1-1 MINK1 IL17RD CTTN ALDOA ARHGEF5 CSTB PRKX SH3BGRL PDZD11 CDV3-1 CD59 MAP4K5 UBB;UBC CAVIN1 CAVIN2 PLEKHA5 HUWE1 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL NEDD4 EPPK1 ESYT1 TJP2 SH3GL3 INPPL1 PEBP1 ARHGAP42 PDGFRB APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 CALD1 RIPK1 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 KLF11 LSR ARAP1 EPN1 EPN2 EPN3 ACTA2 ELF3 MYH9 DOCK1 GRB14-1 RALB RGS16 MVP ASAP1 PDLIM1 MARVELD2 REPS2 MTA2 MAP2K2;MAP2K1 PDLIM4 SNCA EGF SPRY4 HSPE1 TNIP1 SPRY3 APPL1 SPRY2 KRAS SPRY1 ZPR1 DYRK1A CREB1 HDAC1 PIK3R1 PTK2 STK11 MYC MAP2K3 ZFYVE16 TP53 PIK3R2 FOXO4 JUN JUND CAV1 DAB2 SP1 GSK3B PDPK1 FOXO1-1 FOS PIK3CA CRK MAPK1 AP2B1 ITSN2 TFRC CBLB CRKL UBASH3B PRKCD PARD3 PRKD1 PTTG1IP LDHA PLCG2 PLCG1 LYN VASP CLTC SHB PGAM1 VAV1 VAV2 ARHGEF7 NEDD9 RELA PAK1 FLNB MPZL1 DDX3X-1 GIT2 ERBIN ARHGAP35 KIRREL1 DYRK1B PRPF4B DOK1 DOK2 ADAM9 PKP4 RAF1 KHDRBS1 SDCBP CASKIN2 ABL1 NFKB1 PTPRA CDK1 PIK3C2B ACP1 NCK1 YWHAZ PKM LCK CEBPB ATP1A1 MAPK8 MAPK7 PTK2B PTPN12 MAPK14 RPS6KB1 PTPN6 PRKAA1 GSK3A PRKAA2 EGFR RPS6KA2 ERBB2 EIF4EBP1 FYN JAK1 SH2B1 NOS3 CDK5 SH3KBP1 RPS6KA1 JAK2 HRAS PRKCA KIT GRB7 SOCS1 STAT5A STAT5B MTOR CDK2 ELK1 PIK3CG CASP9 PTPN18 RPL30 RPS6KA5 GAB1 MAP3K3 ITCH YWHAB MAPK9 ERBB3 ITGB4 PIK3CD IRS2 PIK3CB RAC1 EPHB2 DSP RHOA MET PLEC COL17A1 PIK3R3 SMAD2;SMAD3 BAD VIM CDH1 PRKCG ARHGEF4 CTBP1 JUP MAP3K4 PIAS3 TYK2 HNRNPA1-1 SOCS3 SCRIB USP6NL ATF1 ARAF HNRNPR ENO1 ELK4 GJA1 TFG MPRIP ANKS1A TGIF1-1 PRKCI FRS2 FRS3 KIAA1217 PRKAR1A KRT6B;KRT6C;KRT6A RBCK1 SERPINB3;SERPINB4-1 IQGAP1 SLC5A5 ANTXR1-1 MYO6 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 ENSA PLEKHN1 APPL2 ANXA1 ANXA4 EPS15L1 PLSCR1 GPRC5A TKT PHLPP1 AHNAK RPS27L HTT SNX33 AP2S1 STX4 RICTOR RPS2 LDLR GSN MCF2 STAT2 HIPK3 DCBLD2 HIPK2 PKN2 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CYSRT1 CDH3 CDH2 CFL1 TOM1 GRB10 MAGI1 DYRK4-1 TOM1L1 TOM1L2 HAT1 PKP2 STAMBP PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 TNK2 PTPRE ACTB-1 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 BCAR3 CALCOCO2 PTEN PTPN23 NCK2 SFPQ-1 CCDC50 ACTR2 PDCD6IP ITGA3 DSG2 SLC25A6 CEBPA WBP2 SRI CDC42 SLITRK6 CSK RBBP7 CTNNAL1 PTPN1 PPP1R14B BAIAP2 NECTIN1 ERRFI1 APP AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 RPS10 TNS3 SLC12A7 ID%NETPATH%ID ID FHL2 PAX5 ELK3 ELK1 RBL1 PSMD4 ATF3 SMAD2;SMAD3 ID3 RAF1 HES1 MYF5 RBL2 TCF7L2 MAP2K2;MAP2K1 ELK4 RB1 MAPK1 SMURF2 CDK2 MAPK3 IL9%NETPATH%IL9 IL9 TYK2 STAT5A STAT5B KAT5 STAT6 IL9R MAPK1 MAPK3 IL3%NETPATH%IL3 IL3 SHC1-1 GSK3A PRKACA-1 INPP5D FOXO1-1 LYN SLC2A1 PIK3R2 GATA2 SOCS2 PIK3CD BCL2L11 KCNIP3 IL3 RARA CRK RACK1 YWHAZ CREB1 GAB1 BCL2L1 PIK3R1 YWHAB PTK2 MAPK1 DOK1 RXRA SOCS3 HRAS PRKCB PRKCA BAD PPP2CB;PPP2CA CSF2RB CRKL GAB2 MAP2K2;MAP2K1 ATF1 GSK3B NFKB1 PTPRC PTPN6 FES IL5%NETPATH%IL5 IL5 SHC1-1 GSK3A ELK1 STAT1 LYN FOXO3 IL5RA ALOX5 RACK1 JAK1 YWHAZ CTNNB1 SOX4 DNM2 PLA2G4A UNC119 IL5 GRB2 IL2RB JUN ATF2 PIK3CG SOS1 RPS6KA1 HCLS1 HRAS RAF1 CBL HCK SYK STAT3 PTK2B BAX SDCBP CRKL SOCS1 PTPN11 MAPK14 MAP2K2;MAP2K1 STAT5A GSK3B STAT5B NFKB1 PRKCD NFKBIA RAPGEF1 IL4%NETPATH%IL4 IL4 SHC1-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PIK3CD IRS2 PIK3CA JAK1 SPI1 AKT1 IL13RA1 IL13 STAM SND1 PTK2 CXCR4 MAPK1 ATF2 IL2RG GRK3 MAPK3 IL4 ETS1 EP300 JAK2 NCOA3 BAD SOCS1 NFKB1 PRKCD NFKBIA ELK1 INPP5D PLCG2 CREBBP CHUK RASA1 CD40 TYK2 CEBPB IKBKB CEBPA CBL MAPK8 SYK STAT3 PTPN11 MAPK14 MAPK11 RPS6KB1 PTPN6 IL-7%NETPATH%IL-7 IL-7 IL7 IL7R SHC1-1 GSK3A FOXO1-1 STAT1 IRS1 JAK3 BAD STAT3 FOXO3 CBLB IRS2 FYN MAP2K2;MAP2K1 STAT5A STAT5B GSK3B AKT1 PIK3R1 STAM MAPK1 IL2RG MAPK3 NOTCH%NETPATH%NOTCH Notch HES1 KAT2B AKT1 PIK3R1 MAPK1 MAPK3 MAML2 MAML1 FHL1 EP300 RBPJ JAK2 LFNG SMAD2;SMAD3 YY1 SIN3A CCN3 CIR1 SKP2 PSENEN HES6 SKP1 RING1 SAP30 NCOR2 NCOR1 MFNG MAML3 NOTCH2 NOTCH4 PSEN2 DTX1 NFKB1 FURIN DLL3 RBX1 APH1A FBXW7 DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 NCSTN APH1B SPEN JAG2 LEF1 CUL1 SMAD1 SRC SNW1 STAT3 APP GSK3B HDAC2 RELA IL2%NETPATH%IL2 IL2 SHC1-1 IRS1 PIK3CD EIF4EBP1 IRS2 FYN PIK3CA EIF4E PIK3CB CRK JAK1 CREB1 RPS6 IL2RB AKT1 PIK3R1 STAM MAPK1 ATF2 IL2RG MAPK3 ETS1 PIK3R3 RAF1 STAM2 CRKL STAT5A STAT5B NFKB1 MTOR CCNE1 CDK2 YBX1 NR3C1 ETS2 ELK1 IL15 PLCB1 PRKCZ TERT MKNK1 STAT4 NMI LYN IL2 PIK3R2 VIL1 IL2RA FOXO3 ITM2B EIF3B BCL2 GRB2 LCK JUN SGK1-1 PIK3CG SOS1 SHB HSP90AA1 SOCS3 CBL JAK3 MAPK8 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 PTPN6 RELA TSLP%NETPATH%TSLP TSLP STAT1 STAT4 STAT6 MAPK8 STAT3 NFKB2 EIF4E MAPK14 MAP2K2;MAP2K1 STAT5A STAT5B NFKB1 NFKBIA AKT1 MAPK9 MAPK1 RELA RELB MAPK3 RANKL%NETPATH%RANKL RANKL MITF MAPK8 REL TRAF6 NFKB2 TRAF5 CHUK TRAF2 TNFRSF11B TREM2 TRAF1 MAPK14 TAB1 MAP3K7 TRAF3 TNFSF11 TAB2 NFKB1 ATP6V1E1 SQSTM1 SPI1 PTK2 IL1%NETPATH%IL1 IL1 PIK3R2 REL CHUK TOLLIP TAB3 PLA2G4A TAB2 MAP2K6 MAP3K14 IL1RN PELI2 AKT1 PIK3R1 IRAK1 IRAK2 JUN RB1 PPP6C MAPK1 FBXW5 ATF2 IL1R1 IL1R2 DOK1 MAPK3 IRAK3 IRAK4 SOD1 IL1A IKBKB IL1B MAP3K2 PELI1 UBE2N ELP1 UBE2V1 MYD88 MAPK8 TRAF6 MAP2K3 MAPK14 TAB1 NFKB1 NFKBIA MAPK9 RELA ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis ILVBL BCAT1 BCAT2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway HK2 HK1 RPIA GPI HKDC1 TALDO1 PGD TKT ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis MTHFD1L MTHFD2 MTR-1 TYMS DHFR2;DHFR FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism HK2 HK1 GALE GALT ALDOC ALDOB HKDC1 ALDOA KHK P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway MEF2B;BORCS8-MEF2B MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 EIF4E MEF2D MAP3K7 MAP3K4 MAP2K6 MAP2K4 MEF2C IL1R1 MAPK14 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway HSPB1 MAPK14 MAPKAPK3 MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR RAC3 AKT1 RAC1 HRAS PRKCG PRKCI PRKCH PRKCB SPHK2 SPHK1 PRKCE PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 CRYAA;CRYAA2 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 LPXN PLCG1 MAPK3 NOS3 BRAF PTK2 VEGFA INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 IL5RA IRS2 SLA2 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 AKT2 RPS6KA2 MYC RPS6KA1 AKT3 IL13RA2 JAK3 IL6R IL13RA1 IL10 IL11 IL4R CHUK PDPK1 IL11RA IL15 IL13 IL18 FOS IL1A IL23A IL3RA SOS1 IL6ST SOS2 IL20RA FOXO3 MAPK7 CXCR1 CXCR2 STAT4 SRF STAT6 MAPK6 ELK1 IL12RB1 IL12RB2 STAT5A STAT5B MKNK1 STAT1 MKNK2 IL10RB STAT2 IL10RA STAT3 MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL9 IL2RB SHC1-1 MAPKAPK2 ARAF PIK3CB AKT1 PIK3CA RAF1 NRAS MAPK1 MAPK3 NOS3 BRAF FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis EARS2 COX10 ALAD QARS1 FECH EPRS1 UROD HMBS RSAD1 CPOX PPOX NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CHRNA3 KCNK9 CHRNA5 CHRNA4 EPB41 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G PRKACA-1 GNG2 EPB41L1 EPB41L2 FLNA DRD2 SLC18A2 DRD4 CHRNB2 CHRNB4 CHRNB3 PPP1CA GNB1 PPP1R1B KCNK3 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis IDI2 PMVK PDSS1 MVD HMGCR LSS FDFT1 HMGCS1-1 SQLE FDPS MVK GGPS1 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway SLC1A3 GRIK4 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN1 GRIN2D VAMP8 GRIN3A VAMP1 SHANK3 VAMP2 VAMP3 SHANK1 GRIA1 SNAP25 GRIA2 GRIK5 STX19 SNAP23 SLC1A1 GRIK3 SLC1A2 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CINP CCND3 CCND2 CCNE1 RPA3 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK12 CDKN1A MAPK13 MAPK11 PIK3CD PIK3CB PIK3C2A AKT2 PIK3CG PIK3C2B AKT3 AKT1 HRAS PDPK1 CCNE1 RB1 PPP2CB;PPP2CA PTEN PIK3C2G PIK3R5 PIK3CA TP63 SIAH1 TPTE;TPTE2 PIK3C3 RBL1 CDK2 CCNG1 CTNNB1 ATM KRAS TP53 PIK3R3 TP73 PIK3R2 ATR PIK3R1 NRAS MAPK14 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ ITPR1 PRKCZ ITPR2 ITPR3 GNA14 PLCG2 GNG10 HRH1 GNG5 PLCG1 PLCZ1 GNG4 GNA11 GNG8 PLCE1 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRIK1 PLCB4 GNAQ GRIN2A HOMER1 PRKX GRM1 GRIN2C PRKACB-1 GRIN2B GRM5 GRIN1 PRKAR1B GRIN2D PRKAR1A GRINA ITPR1 GRIN3A GRIK5 PRKACA-1 GNA11 PRKCB OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAPK12 MAPK13 PLA2G4A MAPK11 ELK1 MYC EEF2K MAP2K3 JUN STAT1 MKNK1 MAX MKNK2 TXN MAPK9 MAPK8 DDIT3 BCL2 MAP2K6 MAP2K4 MEF2C MAPK14 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNB2 GNB4 GNB3 GNB5 PRKX PRKACB-1 KCNK9 ADCY2 GNAI1 GNAI3 PRKACA-1 ADCY7 GNG2 GNAI2 PRKAR2B PRKAR2A HTR1E HTR1F HTR1D HTR1A HTR1B GNAO1 GNB1 KCNK3 GNG10 GNG5 GNG4 GNG8 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA OXTR GNB1 PRKCQ PRKCZ GNA14 PLCG2 GNG10 GNG5 PLCG1 PLCZ1 GNG4 GNA11 GNG8 PLCE1 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNB2 GNB4 GNB3 GNB5 HTR4 GNB1 GNAL ADCY2 GNG10 GNG5 GNG4 ADCY7 GNG2 GNG8 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling GNB2 GNB4 GNB3 PRKACB-1 PRKAR1B PRKAR1A ADCY2 GNAI1 CACNA1G GNAI3 PRKACA-1 ADCY7 PRKAR2B PRKAR2A GNAO1 GNB1 CACNA1B ADCY4 CACNA1A ADCY1 ADCY8 ADCY6 ADCY5 KCNJ3 GABBR2 GABBR1 ADCY9 GNG5 GNG4 GNG8 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBE2D3;UBE2D2 UBE2G2 UBE2D3-1 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 ATG7 UBE2K UBE2B UBE2D4 UBA7 UBE2C UBA6 UBE2E3 UBE2E1 UBE2D1 UBE2E2 UBE2G1 UBE2L6 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway GSK3B APP ACTC1;ACTG2 WNT2B FZD10 RBPJ ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 ACTA2 BACE1 ACTA1 BACE2 ACTBL2 CD44 RBPJL NOTCH2 CTNNB1 NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 PSEN2 LRP5 WNT8A LRP4 WNT8B LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 APBB3 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 JUP FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A LRP1B AFDN ACTB-1 NECTIN1 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 IL4I1 ALDH2 ALDH1B1 ALDH3B2;ALDH3B1 ALDH1A2 ALDH1A1 ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 ALDH1L1 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 TP73 COP1 MDM2-2 MDM4 TP63 TP53 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis ILVBL BCAT1 BCAT2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK3 PANK1 PPCS DCAKD METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation BLNK VAV3 SYK NFKBIL1 VAV1 VAV2 BTK CD79B CD79A CD19 LYN IKBKB MAP3K2 MAP3K3 CALM3;CALM1 MAPK10 NFKBIA PTPRC PTPN6 GRB2 CD22 CHUK FOS SOS1 SOS2 ITPR1 ITPR2 ITPR3 MAPK14 MAPK12 MAPK13 MAPK11 ARAF PIK3CD PIK3CB PIK3CG JUN MAPK9 RAC1 MAPK8 HRAS PRKCB PRKCD PIK3CA RAF1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 MAPK3 PPP3CA PPP3CB P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation PPP2CB;PPP2CA TP63 TP53 AKT2 TP73 IGBP1 AKT3 PRKAA1 PRKAB2 PRKAA2 PRKAG1 AKT1 TSC2 TSC1 PRKAB1 RPS6KB1 RHEB RPS6KB2 EIF4EBP1 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis DAGLA PLCB3 LIPH LPL PLA1A PLCB1 PLCB2 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB GMDS PMM1 GMPPA PMM2 MPI MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing SNRNP40 PRPF3 SNRPB2 ZRSR2-1 SNRPA HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN1 CREBBP AKT2 EGLN3 EGLN2 RORC HIF1A ARNT AKT3 TXN2 VHL TXN AKT1 MTOR THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor GTF2E2 PSMC3IP CREB3L3 TAF1C CREB3L4 POLR2C CREB3L1 CREB3L2 POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L BRF2 TBP TAF12 PRKAR1B BRF1 PRKAR1A MTERF2 TAF11 GTF2H1 GTF2H3 GTF2F1 GTF2H4 GTF2F2 TBPL2 TAF8 TBPL1 TAF7 TAF6 PRKAR2B TAF4 PRKAR2A TAF2 CREB5 CREBBP GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway OPRD1 POMC GNB2 GNB4 GNAO1 GNB3 GNB5 GNB1 ADCY2 GNG10 GNAI1 GNG5 GNAI3 GNG4 ADCY7 GNG2 GNAI2 GNG8 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis AVP OXT-1 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion LGSN GLUL GLUD1;GLUD2 UNTITLED%PANTHER PATHWAY%P00019 untitled AKT2 AKT3 ITPR1 ITPR2 ITPR3 GNA14 GNA11 PLCB3 PLCB4 GNAQ PLCB1 PLCB2 ARAF PRKACB-1 PRKAR1B PRKAR1A AKT1 ADCY2 PRKCG PRKACA-1 PRKCI PRKCH ADCY7 PRKCB PRKAR2B PRKAR2A PRKCE PRKCD PLA2G4A PRKCA PRKCQ GNAL RAF1 ADCY4 GUCY1B1 ADCY1 EDNRA ADCY8 EDNRB ADCY6 PRKG2 ADCY5 PRKG1 GUCY1A2 GUCY1A1 EDN1 ADCY9 PRKCZ EDN2 EDN3 MAP2K2;MAP2K1 GNAS-1 ADCY3 MAPK1 ADCY10 MAPK3 NOS3 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis TYMS DHFR2;DHFR GCH1 FPGS 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PRKCZ GNA14 PLCG2 GNG10 GNG5 PLCG1 PLCZ1 GNG4 HTR2B GNA11 HTR2A GNG8 PLCE1 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway MAP3K2 MAP3K3 MAPK10 MAP3K4 MAP2K4 MAPK13 ARAF PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B MAP2K3 MAPK9 RAC1 MAPK8 HRAS PIK3CA PIK3C3 RAF1 PXN PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 MAPK3 BRAF PTK2 COL16A1 COL12A1 ITGA2B ARPC5L CRKL MAP3K5 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 ELMO1 COL8A2 COL4A6 ELMO2 COL8A1 ACTG1 COL4A5 TLN1 VCL COL17A1 COL13A1 ARL1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 PARVA ARPC5 PARVB ARHGAP26 COL1A2 ARPC2 COL5A1 LIMS4;LIMS1 SOS1 ARPC3 COL5A3 SOS2 ITGA10 ACTBL2 ITGA11 COL5A2 COL20A1 COL9A1 ITGBL1 COL9A3 COL9A2 MAPK6 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ARPC1A ITGB2 ILK LAMC2 ITGAE LAMC1 RND2 ITGAL RND3 RND1 ITGAX COL10A1 SHC1-1 ITGB8 ITGB7 ITGAV ITGB6 ITGA4 ITGA3 ITGA2 ITGA1 RHOC ARFGAP1 RHOA RHOB ARHGAP10 RAP2A COL2A1 RAP2B ITGAD COL6A2 COL6A1 RAPGEF1 ITGA8 ITGA7 COL6A3 ITGA6 ACTB-1 ITGA5 DOCK1 CRK ARF6 FLNA ITGA9 LAMA5 COL15A1 LAMA2 SRC LAMA1 COL11A1 LAMA4 COL11A2 LAMA3 NTN4 ASAP1 CDC42 MICALL1 PTK2B FLNB FYN CSK LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 COL3A1 BCAR1 LIMS2 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway PDGFRA PDGFRL VAV3 ERF ERG SHC3 VAV1 PDGFB VAV2 PDGFA ARHGAP15 ARHGAP12 SRGAP3 SRGAP1 FLI1 MAP3K2 FEV GRAP ARHGAP9 MAPK10 GSK3A ARHGAP5 ARHGAP6 GRB2 RERG ARHGAP4 RASA4;RASA4B NCK2 JAK2 GABPA JAK1 NCK1 GAB1 GAB2 ETV3 RPS6KB1 ELF1 ELF2 RPS6KB2 ELF3 ELF4 ELF5 RASA1 RASA2 RPS6KC1 PIK3R5 SPDEF MYCBP-1 ELP1 USF2 RAB11B NIN PKN2 SRF ELK1 RPS6KA4 RPS6KA5 ITPR1 ITPR2 MKNK1 ITPR3 MKNK2 MAP3K4 MAPKAPK2 ARAF ARHGAP1 PIK3CD PIK3CB ETS1 PIK3CG JUN ARHGAP8;PRR5-ARHGAP8 MAPK8 HRAS PRKCA PIK3CA PIK3C3 RAF1 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLCG1 MAPK3 BRAF GSK3B IKBKB ELK4 RPS6KA3 RPS6KA6 AKT2 RPS6KA2 MYC RPS6KA1 JAK3 CHUK PDPK1 ARHGAP26 FOS SOS1 SOS2 MAPK7 STAT4 STAT6 MAPK6 STAT5A STAT5B STAT1 STAT2 STAT3 MAPK15 SHC1-1 ARHGAP10 EHF ARHGAP42 OPHN1 GRAP2 PDGFRB NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway ACTC1;ACTG2 ACTG1 ACTA2 ACTA1 ACTBL2 SLC44A3 ACTR1A ACTR1B MYO18B MYO18A SLC18A3 CHRNB1 MYO7B MYO7A SLC5A7 MYH1 MYH3 MYO3B MYO3A MYH8 MYH9 MYH6 MYH7 CHRNA1 PLEKHH3 CHRNA9 CHRNA7;CHRFAM7A CHRNA2-1 CHRND CHRNG CHRNE MYO6 MYH13 CHRNA10 MYH14 MYH11 MYH10 MYH7B MYO10 MYO5A MYO19 MYO1G;MYO1D MYO9A CHRNA3 MYO16 MYO1E CHRNA5 MYO1B CHRNA4 SLC6A8 MYO1C CHRNA6 MYO1A MYO15A MYO5B MYO5C MYO1F ACTB-1 CHRNB2 CHRNB4 CHRNB3 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway STAT5A STAT5B STAT1 JAK2 JAK3 JAK1 STAT3 STAT4 STAT6 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B RAC1 VASP NTN1 NTN3 ABLIM1 NTNG1 NTNG2 UNC5B PIK3R5 DCC PIK3CA NFATC3 NFATC2 UNC5C UNC5D NFATC4 NTN4 RHOU CDC42 PIK3R3 PIK3R2 PIK3R1 PLCG2 PLCG1 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC6A15 SLC6A20 SLC18A1 SLC18A2 SLC6A2 SLC6A3 SLC6A19 SLC6A18 SLC6A17 SLC6A16 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation CYP2A13;CYP2A6;CYP2A7-1 FMO3 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 INMT COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MTR-1 MAT2A MAT1A CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK CFL2 CFL1 STMN1 TUBB1 TUBB2B;TUBB2A PFN1 PFN2-1 PFN3 TUBB3;TUBB6 ROCK1 ROCK2 PAK1 PAK3 ACTC1;ACTG2 PAK2 PAK5 PAK4 LIMK1 ACTG1 ARPC4 TUBB4B DIAPH1 DIAPH2 TUBB4A;TUBB;TUBB8B;TUBB8 ARPC5 ARPC2 ACTA2 ACTA1 ARPC3 ACTBL2 MYH1 MYH3 ARPC1B MYO3B ARPC1A MYO3A MYH8 MYH9 MYH6 MYH7 MYH13 MYH14 MYH11 MYH10 MYH7B RHOC RAC1 ACTB-1 RHOU CDC42 MYLK2 BUB1B-PAK6;PAK6 STMN4 WASL MYLK3 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade IRS1 IRS2 RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 MAP2K3 IRS4 IGF1R INS;INS-IGF2 INSR INSRR IGF2 RPS6KB1 IGF1 IGF2R RPS6KB2 FOS RASA1 SOS1 SOS2 RAF1 ELK1 RPS6KA4 RPS6KA5 MAP2K2;MAP2K1 MAPK1 MAPK3 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway IFNGR1 IFNGR2 STAT1 JAK2 JAK1 IFNG 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 DDC TPH1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UCK1 NME4-1 NME2 NME3 UPRT UPP1 UCKL1 ADAT2 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway SLC1A3 GRIK4 GRIK1 GRIK2 SLC1A6 SLC1A7 GRIN2A SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN1 GRIN2D VAMP8 GRIN3A VAMP1 VAMP2 VAMP3 GRM4 GRM7 GRM6 GRM8 CACNB1 STX1A CACNA1E VTI1A SLC17A7 GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX GRM1 PRKACB-1 GRM5 PRKAR1B PRKAR1A GNAI1 PRKACA-1 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 CACNA1B CACNA1A GRIA1 SNAP25 GRIA2 ADCY10 GRIK5 SNAP23 SLC1A1 GRIK3 SLC1A2 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway MAP3K5 IKBKB MAPK10 NFKBIA AKT2 AKT3 CHUK IGF2R FOS ATF1 TP53 ATF2 TRADD FASLG TNF CASP7 CASP8 AIFM1 MAP2K4 CASP10 CASP3 TNFSF10 GZMH;GZMB-1 MAP4K2 DAXX ENDOG APAF1 TRAF2 TNFRSF1B TNFRSF1A GZMH-1 MADD LTA LTB TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A ATF6 PIK3CD ATF3 PIK3CB JDP2 BIRC2 ATF4 PIK3CG BIRC3 ATF6B CASP9 MAP2K3 CREM XIAP JUN RELA RELB AKT1 CYCS-1 MAPK9 MAPK8 BCL2L11 RIPK1 PRKCG BAK1 BCL2 FADD PRKCH MAP2K7 PRKCB MAP4K3 MAP4K4 MAP3K1 PRKCE CRADD PRKCD BIK EIF2AK2 PRKCA DIABLO-1 PIK3CA EIF2S1 NFKB1 NFKB2 ATF7;ATF7-NPFF PRKCQ PRKRA REL BAX FAS MAP3K14 BCL2L1 MAPK1 MAPK3 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway GSK3B PAK1 RPS6KA3 PAK3 PAK2 MAPK10 GSK3A RPS6KA6 RPS6KA2 GRB2 RPS6KA1 AKT3 PDPK1 SOS1 SOS2 KRAS SRF ELK1 STAT1 ATF2 STAT3 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 SHC1-1 MAPKAPK2 ARAF RHOC PIK3CD PIK3CB RHOA RHOB ETS1 PIK3CG MAP2K3 JUN RAC3 AKT1 MAPK9 RAC1 MAPK8 HRAS MAP2K7 MAP3K1 PIK3CA PIK3C3 RAF1 CDC42 MAP3K7CL RALA-1 TIAM1 EXOC2 RALB PLD1 PLD2 NRAS MAP2K2;MAP2K1 RALGDS RGL1 MAPK1 MAPK3 BRAF ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin PLCB3 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PRKCA GNB1 RAF1 ELK1 ITPR1 ITPR2 ITPR3 MAP2K2;MAP2K1 ARRB1 GNG10 MAPK1 ARRB2 GRK3 GRK2 MAPK3 GNG4 EGR1 AGT GNG8 AGTR1 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2H3 GTF2F1 GTF2H4 GTF2F2 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway WRN CCNB1 CDKN1A SUMO1 SIN3A SUMO3 CHEK2 TRAF2 SUMO2 HMGB1-1 SFN MTA2 EP300 GTSE1 CDKN2D GADD45B GADD45A CDKN2A CDC25C AKT2 SIRT1 PML GADD45G KAT2B AKT3 KAT6B CDK1 AKT1 PDPK1 CCNE1 PTEN PIK3CA TP63 TPTE;TPTE2 CDK2 ATM TP53 CREBBP TP73 ATR MDM2-2 MDM4 HDAC1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway SNAP29 VAMP8 VAMP1 TRH TSHB VAMP2 TRHR VAMP3 CACNB2 CACNB3 CACNB4 STX3 CGA CACNB1 CACNA1E GNA14 GNG10 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI PRKCH GNG2 PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ CACNA1B CACNA1A PRKCZ PLCG2 SNAP25 PLCG1 SNAP23 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis HSD17B1 HSD17B2 HSD17B3 HSD17B6 HSD17B7 LIPA CYP19A1 SOAT1 SOAT2 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway CTNND2 CTNND1 PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CTNNB1 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 FAT2 DCHS1 FAT3 PCDHB3 PCDHB7 PCDHGB7 PCDHGB6 PCDHGB2 PCDHA8;PCDHA6-1 PCDHGA8 PCDHGA7 PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PCDHGA2 PCDHGA1 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PTPN1 PCDH9 PCDH7 PCDH8 PCDHB15 PCDHB14 PCDHB5-1 PCDHB16 ACTC1;ACTG2 WNT2B FZD10 ACTG1 CDH3 CDH1 ACTR2 WNT5B WNT5A WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 LEF1 WNT8A WNT8B FSTL1 WNT6 WNT11 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A ACTB-1 UNTITLED%PANTHER PATHWAY%P06664 untitled RELA SKIL TGIF1-1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle PDHA1 MDH1 OGDH SUCLG1 SDHC ACO2 PDK2 CS FH ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1-2 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism CDA NT5E ALDH6A1 DPYSL5 ABAT DPYSL2 DPYS DPYD DPYSL3 UPB1 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE;RPEL1 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway PRKAR2A GNB2 GNB4 GNB3 GNB5 GNB1 GNAL PRKX PRKACB-1 ADCY2 GNG10 ADRB1 GNG5 PRKACA-1 GNG4 ADCY7 GNG2 GNG8 PRKAR2B INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade GSK3B PTEN PIK3CA IRS1 TPTE;TPTE2 IRS2 FOXO3 GSK3A MDM2-2 MDM4 IRS4 IGF1R TSC2 INS;INS-IGF2 INSR TSC1 INSRR FOXO1-1 IGF2 PDPK1 IGF1 IGF2R HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway PRKAR2A GNB2 GNB4 GNB3 GNB5 GNB1 GNAL PRKX PRKACB-1 ADCY2 GNG10 GNG5 PRKACA-1 GNG4 HRH2 ADCY7 GNG2 GNG8 PRKAR2B BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNB2 GNB4 GNB3 GNB5 GNB1 GNAL ADCY2 GNG10 GNG5 GNG4 ADCY7 GNG2 ADRB3 GNG8 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism XDH NT5E GDA AMPD3 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR-1 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway CRHR1 CRHR2 POMC GNB2 CRH GNAQ GNB4 GNB3 GNB5 GNB1 GNAL GNA14 GNG10 GNG5 GNG4 GNG2 GNA11 GNG8 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway APP MAPK10 KAT5 PSENEN CACNB2 ADAM17 PKN3 BACE1 CACNA1D KLC1 BACE2 CACNA1F KLC4 KLC3 MAPK7 KLC2 PKN2 CACNA1S MAPK4 APBA1 PKN1 MAPK6 APBA3 CACNB1 APBA2 PSEN2 PSEN1 MAPK15 NCSTN APH1B MAPK14 CHRNA7;CHRFAM7A MAPK12 MAPK13 MAPK11 MAPK9 CACNA1C MAPK8 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA PRKCQ PRKCZ MAPK1 MAPK3 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS;CBSL AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo NTN3 NTNG1 NTNG2 DCC SRGAP1 NTN4 RHOC CDC42 CXCR4 ROBO1 CXCL12 SLIT1 ABL1 SLIT3 RAC1 SLIT2 NTN1 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis NME1 NME4-1 NME2 NME3 CPS1 CAD CTPS2 CTPS1 DSCAML1 DHODH EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway MAP3K5 SHC3 MAP3K2 MAP3K3 GRAP MAPK10 AKT2 RASA4;RASA4B AKT3 GAB1 GAB2 RRAS RASA1 RASA2 PIK3R5 SOS1 SOS2 STAT4 STAT6 STAT5A STAT5B STAT1 STAT2 STAT3 MAP3K4 MAP2K6 MAP2K4 MAPK14 ERBB4 PEBP1 MAPK12 PEBP4 MAPK13 RRAS2 MAPK11 GAB3 SHC1-1 MRAS PHLDB2 RASAL2 EGFR ERBB3 ERBB2 SPRY4 ARAF DAB2IP SPRY3 PIK3CD NF1 PIK3CB SPRY2 PIK3C2A SPRY1 PIK3CG PIK3C2B MAP2K3 AKT1 MAPK9 RAC1 MAPK8 HRAS PRKCG PRKCI PRKCH MAP2K7 PRKCB PRKCE PRKCD PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 SHC2 PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLCG1 MAPK3 BRAF PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGB FGA SERPINB2 MMP1 SERPINE1 MMP3 SERPINF2 FGG PLAUR PLAT PLG MMP9 MMP13 PLAU PNAT%PANTHER PATHWAY%P05912 PNAT GNB2 GNB4 GNB3 SNAP29 PRKX PRKACB-1 KCNK9 VAMP8 VAMP1 EPB41 VAMP2 ADCY2 VAMP3 GNAI1 GNAI3 PRKACA-1 STX3 ADCY7 GNAI2 EPB41L1 GNAZ PRKAR2B EPB41L2 PPP1CC PRKAR2A FLNA DRD1 DRD2 SLC18A2 DRD5 DRD4 PPP1CA GNB1 PPP1R1B KCNK3 SLC6A3 SNAP25 SNAP23 GNG4 GNG8 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway CREBBP SHH SMO FBXW11 STK36 PTCH1 GLI1 BTRC GLI3 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway GNB2 GNB4 GNB3 GNB5 PRKX PRKACB-1 PRKAR1B PRKAR1A SLC6A8 GNAI1 GNAI3 PRKACA-1 GNAI2 PRKAR2B PRKAR2A GNAO1 GNB1 CHRM2 CHRM4 GNAT2 GNAT1 KCNJ5 KCNJ6 SLC18A3 KCNJ3 KCNJ9 SLC5A7 GNG10 ADCY10 GNG5 GNG4 GNG8 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 AMDHD2 NPL GFPT2 GFPT1 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway SNIP1 JUNB ACVR1 LEFTY2;LEFTY1 FOXH1 TGFBR2 ACVR1B ACVR1C SMAD2;SMAD3 GDF10 GDF11 SMAD1 TGFB2 SMAD4 JUND MAPK10 SMURF2 TGFB3 SMURF1 GDF15 GDF2 GDF1 SMAD9 BMP8B INHBB INHBA GDF3 GDF6 RRAS SMAD6 INHBC SMAD5 ACVR2B BMP7 GDF5 ACVR2A BMP6 SMAD7 GDF7 INHBE BMP5 FOSL1 SKI BMP4 GDF9 BMP3 BMP2 BMP1 GDNF TLL2 CREBBP TLL1 BMPR1B NODAL DCP1B BMPR1A ATF2 MAP3K7 MAPK14 MAPK12 MAPK13 MAPK11 TAB1 EP300 JUN MAPK9 MAPK8 HRAS MAP3K7CL NRAS ACVRL1 BMP10 BMPR2 MAPK1 MSTN SKIL AMHR2 CITED1 MAPK3 CITED2 TGFBR1-1 BMP15-1 BMP8A;BMP8B BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation GP5 ITGA2B F3 GP9 PROCR F7 F8 F9 PROC F13B KLKB1 F2RL3 FGB FGA FGG PLAUR PLAT PLG PLAU PROS1 TFPI KNG1 THBD VWF F10 GP1BB F12 F2R GP1BA F2 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway GSK3B GNB2 GNAQ GNB4 IRS1 GNB3 GNB5 PTGER1 FOXO4 GNGT1 YWHAZ PIK3CB AKT2 CASP9 AKT3 AKT1 GNAI1 INSR FOXO1-1 GNAI3 RPS6KB1 PDPK1 GNAI2 RPS6KB2 PIK3R5 PIK3CA SOS1 GNB1 SOS2 FOXO3 GNAT2 PIK3R3 PIK3R2 PIK3R1 NRAS GNA14 NOS3 GNA11 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway GRM3 GRM2 CALM3;CALM1 GSK3A CREBBP GNG10 HRH1 GNG5 GNG4 GNG8 CREB3L3 GNB2 CREB3L4 CREB3L1 CREB3L2 EP300 GNGT1 GRM1 CHRM3 PRKACB-1 CHRM1 GRM5 CHRM5 PRKAR1B HTR6 PRKAR1A HTR7 ADORA3 ADORA1 PHKA1 PHKA2 MTNR1A MTNR1B ADRB2 HRH3 CLTCL1 GNAI3 HRH4 ADCY7 PHKB GNAI2 PRKAR2B PYGB PRKAR2A CLTC HTR1E CLTB CREB5 HTR1F CLTA OPRD1 HTR1D PYGM HTR1A ADRA1D HTR1B PYGL ADRA1B ADRA1A HTR4 GYS2 GNAL GYS1 GNRHR SSTR1 ADCY4 OPRM1 SSTR2 ADCY1 ADRA2C ADCY8 SSTR3 ADCY6 ADRA2B ADCY5 SSTR4 KCNJ3 SSTR5 CREB3 ADCY9 CREB1 ADORA2A ADORA2B OPRL1 ADCY3 PHKG1 PHKG2 OPRK1 GPR50 HTR5A HTR2B HTR2A GSK3B RAP1B ADRB1 RAP1A HRH2 ADRB3 GRM4 GRM7 GRM6 GRM8 CREM ADCY2 GNAI1 PRKACA-1 GNG2 DRD1 DRD2 DRD5 DRD4 GNB1 CHRM2 CHRM4 KCNJ5 KCNJ6 KCNJ9 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway FGFR4 FGFR3 FGFR2 FGFR1 MAP3K5 SHC3 MAP3K2 MAP3K3 GRAP MAPK10 AKT2 PTPN6 RASA4;RASA4B AKT3 RASA1 RASA2 SOS1 SOS2 MAP3K4 MAP2K6 MAP2K4 MAPK14 PEBP1 MAPK12 MAPK13 MAPK11 SHC1-1 SPRY4 ARAF SPRY3 PIK3CD PIK3CB SPRY2 PIK3C2A SPRY1 PIK3CG PIK3C2B MAP2K3 AKT1 MAPK9 RAC1 MAPK8 HRAS PRKCG PRKCI PRKCH MAP2K7 PRKCB PRKCE PRKCD PRKCA PIK3CA PIK3C3 PRKCQ RAF1 PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLCG1 MAPK3 MAP3K6 FRS2 FRS3 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis ASL NAGS ASS1 OTC CPS1 CAD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction GNB2 GNB4 GNB5 CALML3 PDC GRK1 RHO CNGA1 GNGT1 CNGA3 CALM3;CALM1 PDE6B PDE6A RGS9 RCVRN GNG13 CNGB3 CNGB1 GNG2 GNB1 GNAT1 GNG10 GNG5 GNG4 GNG8 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK12 SFN YWHAZ MAPK10 YWHAE PRKN YWHAB PPP1R8;STX12 MAPK9 PSMB10 MAPK8 PSMA7 PSMA8 PSMB7 YWHAQ PSMB3 CCNE1 PSMB1 NDUFV2 YWHAG SNCA YWHAH GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 CASK GPR37L1 MAPK7 SNCAIP SEPTIN4-1 PSMA2-1 PSMA5 PSMA6 PSMA3 ELK1 PSMA4 TH CCNE2 SLC6A3 PSMA1 PLD2 MAPK1 MAPK15 MAPK3 MAPK14 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 GRIN2A CHRM3 GRIN2C CHRM1 GRIN2B GRIN1 GRIN2D GRIN3A PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA PKN3 GNB1 PRKCQ PKN2 PKN1 SLC18A3 ITPR1 PRKCZ ITPR2 SLC5A7 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway OPRD1 GNB2 GNB4 GNB3 GNB5 GNB1 PDYN PENK ADCY2 GNG10 GNAI1 GNG5 GNAI3 GNG4 ADCY7 GNG2 GNAI2 GNG8 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication RPA2 POLA1 POLD1 POLD2 TOP1 DNA2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TOP2A RFC5 TOP2B RFC3 PCNA RFC4 RFC1 RFC2 PRIM1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis NME1 AK1 AK2 GMPS AK3 AK5 AK8 ATIC GUK1 PPAT AK4-1 ADSL RRM1 NME5 NME6 RRM2B NME7 IMPDH2 ADSS1 ADSS2 GART RRM2-1 NME4-1 NME2 NME3 DSCAML1 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway RARA GC F13B RXRA VDR HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway GRM3 GRM2 GNG13 DNAJC27 RAP1B RAP1A GRM4 GRM7 GRM6 GRM8 CACNA1E ITPR1 ITPR2 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 PLCB1 PLCB2 GNGT1 GRM1 CHRM3 RHOA CHRM1 GRM5 CHRM5 ADORA3 ADORA1 PRKCG PRKCI CLTCL1 PRKCH GNG2 PRKCB CLTC CLTB PRKCE DRD1 DRD2 CLTA BDKRB2 PRKCD OPRD1 DRD5 BDKRB1 DRD4 GARNL3 PRKCA ARHGEF1 GPR45 GNAO1 RASGRP2 RASGRP1 GNB1 PRKCQ RASGRP4 GNRHR CACNA1B RAP1GAP CHRM2 SSTR1 RASGRP3 CHRM4 OPRM1 CACNA1A SSTR2 SSTR3 SSTR4 SSTR5 PRKCZ ADORA2A ADORA2B OPRL1 OPRK1 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis PDGFRA BIRC5 GRB14-1 DLL1 DLL3 DLL4 PDGFB ANGPT1 PDGFA DLK1 APC TEK GRAP NCK2 JAK1 NCK1 RASA1 CTNNB1 HSPB1 MAP2K4 F2R MAPK14 MAPKAPK3 MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 JUN ARHGAP8;PRR5-ARHGAP8 KDR AKT1 MAPK8 HRAS PRKCG PRKCI PRKCH PRKCB SPHK2 SPHK1 PRKCE PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 CRYAA;CRYAA2 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 LPXN PLCG1 MAPK3 NOS3 BRAF FRS2 PTK2 FRS3 VEGFA GSK3B CRKL FGFR1 PAK1 PAK3 PAK2 WNT2B AKT2 RBPJ AKT3 WNT5B WNT5A FOS SOS1 SOS2 RBPJL NOTCH2 NOTCH1 NOTCH4 STAT1 STAT3 DVL1 DVL2 DVL3 SHC1-1 WNT1 WNT2 FZD1 TCF7L2 WNT10B RHOC WNT10A FZD3 RHOA FZD2 RHOB FZD5 WNT7B WNT7A CRK MAP3K1 SRC FGF1 JMJD7-PLA2G4B;PLA2G4B EPHB2 EPHB1 EPHB3 DOK1 DOK2 DOK3 EPHA3 PLD1 GRB7 PLD2 TCF7 EFNB2 EFNB1 PDGFD PDGFC JAG2 JAG1 APC2 PLA2G4D PDGFRB AXIN1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis NME1 RRM1 NME4-1 TYMS RRM2B NME2 NME3 DTYMK DUT ADAT2 RRM2-1 DSCAML1 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking UNC13B SYT5 UNC13C SYT3 SYT2 RAB3A SYT1 LOC102724488;SYT15 STX1A STXBP1 UNC13D SYT7 VAMP1 SYT6 RIMS1 SNAP25 SYT12 SYT11 STX2 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 LYN CALM3;CALM1 MAPK10 NFKBIA GRB2 JAK2 CLU IER3 RPS6KB1 RPS6 RHEB PTGS2-2 CETP EIF4EBP1 ARHGEF28 MAP2K5 YES1 SP1 SP3 SNAI1 TCF4 MAP3K11 RYR1 RYR2 ELAVL1 RYR3 CD38 CTNNB1 GAST NOS1 CCKBR SRF HSPB1 AKT1S1 ELK1 PPARG HBEGF GUCY2D ITPR1 NR2C2 AKAP1 HDAC7 EIF4E BAD MEF2D PTPN11 CCK TPCN2 MAP2K6 TPCN1 MAP2K4 CAMK4 MEF2C MAPK14 MEF2B;BORCS8-MEF2B TRAF6 ARAF PIK3CB PRKACB-1 JUN AKT1 MAPK9 RAC1 MAPK8 BCL2 PRKCH PRKCB PRKCE PRKCD PLA2G4A PRKCA PRKD2 NFATC2 PRKCQ PRKD1 RAF1 ADCY1 PXN PRKG1 PIK3R1 CREB1 MAP2K2;MAP2K1 MAPK1 PLCG1 MAPK3 BRAF PTK2 GSK3B CXCL8 IRS1 ODC1 ROCK1 ELK4 PAK1 RPS6KA3 RPS6KA1 CDH1 YWHAB FOXO1-1 PDPK1 FOS SOS1 FOXO3 MAPK7 ITGB1 ATF2 STAT3 CASP3 SHC1-1 ITGAV RHOA CREM MMP3 PRKACA-1 GNG2 PLAU CRK SLC18A2 SRC GNB1 BAX MAP3K14 CDC42 BCL2L1 PTK2B ARRB2 BCAR1 EGR1 PPP3CA GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis ENO1 HK2 BPGM HK1 ENO2 GAPDH-1 PFKL PKM PGK1 PFKM ALDOA GPI HKDC1 TPI1 PKLR PGAM2 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway DLL3 DLL4 DLK1 MAML1 NCOR2 NUMB RBPJL CIR1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 RBPJ JAG2 JAG1 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ABAT ALDH5A1 GAD1 GAD2 CSAD FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway DAXX MAP3K5 APAF1 MAPK10 FAF1 CAPG LMNB2 LMNB1 CASP9 SCIN CASP6 JUN LMNA DFFB MAPK9 PARP3 MAPK8 PARP4 GSN PARP1 FADD PARP2 CFLAR FAS FASLG CASP7 CASP8 MAP2K4 CASP10 CASP3 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway JUNB VAV1 GRAP JUND JAK2 KRAS ITPR1 ITPR2 ITPR3 MYH1 MYH3 GNA14 GNG10 MYO3B VWF MYO3A MYH8 GNG5 PLCZ1 MYH9 MYH6 GNG4 MYH7 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNAQ GNB3 MYH13 PLCB1 MYH14 PLCB2 MYH11 PLCD4 MYH10 PLCD1 ARAF MYH7B PRKX PIK3CD PIK3CB PRKACB-1 PIK3CG JUN AKT1 RAC1 GNAI3 PREX1 PRKCB GNAI2 CCRL2 PF4;PF4V1-1 PRKCE LTB4R2 CCL3L1;CCL3L3;CCL3;CCL18 IFNAR1 CCL13;CCL2 C5AR1 PIK3CA FPR1 NFATC3 GNAO1 CCR10 NFATC2 CCR1 XCR1 NFATC1 NFATC4 RAF1 CXCL10 CX3CL1 CCR9 CCR8 CCR7 ADCY6 CCR6 ADCY5 CCR5 CCR4 CCR3 PRKCZ CCR2 RHOG NRAS CX3CR1 PLCG2 NFAT5 CAMK2D MAPK1 CCL11 PLCG1 CAMK2A MYLK2 CXCR5 MAPK3 BUB1B-PAK6;PAK6 CXCR6 CCL4L2;CCL4L1;CCL4 CCL8 MYLK3 CCL5 COL12A1 MYLK CXCR3 CCL22 ARPC5L CCL21 CXCL8 CCL20 CCL27 CCL26 ROCK1 IKBKB PAK1 PAK3 ACTC1;ACTG2 PAK2 PAK5 AKT2 PAK4 ACTG1 ARPC4 AKT3 RRAS CHUK PDPK1 IFNG ARPC5 ARPC2 ACTA2 SOS1 ARPC3 ACTA1 CASK ACTBL2 COL20A1 CXCR1 CXCR2 ITGB1 CXCR4 COL14A1 ARPC1B ARPC1A STAT3 IL2 ITGAL SHC1-1 ITGB7 RHOC RHOA COL6A2 RELA COL6A1 RELB ADCY2 GNAI1 COL6A3 PRKACA-1 ACTB-1 GNG2 NFKB2 CDC42 PTK2B XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway HPRT1 PNP-1 PRTFDC1 GDA HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease GRIK4 ARPC5L GRIK1 GRIK2 TUBB1 TUBB2B;TUBB2A CYFIP2 TUBB3;TUBB6 GRIN2A CYFIP1 HIP1 AP2A1 AP2A2 ACTC1;ACTG2 CAPN9 CAPNS1 GRIN2C CAPN6 GRIN2B CAPNS2 GRIN1 ACTG1 CAPN7 GRIN2D CAPN5 TUBB4B CAPN2 GRIN3A CAPN3 CAPN1 TUBB4A;TUBB;TUBB8B;TUBB8 IFT57 DYNC2H1 DNAI2 ACTR2 DYNC1LI1 DYNC1LI2 RHOJ GAPDHS HAP1 RHOQ DNAH3 ARPC5 DYNC1I2 FOS DNAH7 DCTN1 SP1 DNAH8 ACTA2 DNAH5 TP63 HTT ACTA1 KALRN CYC1 ACTBL2 DYNC1I1 DYNC1H1 BDNF HIP1R CAPN11 CAPN12 TP53 CAPN10 CREBBP DLG4 TP73 DNAL4 ARPC1B ARPC1A CASP8 MAP2K4 CASP3 GAPDH-1 APAF1 MAP3K10 EP300 TBP JUN MAPK9 RAC1 MAP2K7 ACTB-1 TAF4 CLTB CDC42 RHOG GRIK5 GRIK3 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism PDHA1 ACLY PC PKM ME1 PCK1 CLYBL CS PKLR T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation VAV3 VAV1 VAV2 IKBKB PAK1 PAK3 CALM3;CALM1 PAK2 NFKBIA AKT2 PTPRC AKT3 NCK2 NCK1 CHUK FOS SOS1 SOS2 ITPR1 CD86 CD80 CD3G CD3E CD3D PPP3CC ZAP70 LCK LCP2 CD28 CD247 LAT ARAF PIK3CD PIK3CB PIK3CG JUN AKT1 MAPK9 RAC1 MAPK8 HRAS MAP3K1 PIK3CA PIK3C3 PRKCQ RAF1 CDC42 PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 MAPK1 PLCG1 MAPK3 BRAF PPP3CA GRAP2 PPP3CB TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway ECSIT TANK TRAF6 TBK1 IRAK1 MAP3K8 IKBKE TAB1 TICAM2 IKBKB IRAK4 TICAM1 TIRAP IRF3 NFKBIA TOLLIP TLR9 TLR8 TLR7 TLR10 MAP2K3 TLR6 JUN NFKBIE TLR4 TLR3 MAPK9 MYD88 MAPK8 TLR2 CHUK ELK1 MAP2K2;MAP2K1 MAP3K7 MAPK3 MAPK14 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway TBL1XR1 CSNK1G2 EP400 BCL9 TPTEP2-CSNK1E;CSNK1E PPP2R5E DACT1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C SMAD1 ARID1A SAG SMAD4 SMARCD1 SMARCD2 HDAC2 SMARCD3 HDAC3 HDAC8 CTNNAL1 SMARCE1 SMAD5 PPP2CB;PPP2CA SIAH1 CTNNB1 ITPR1 ITPR2 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 PLCB1 PLCB2 NFATC3 NFATC2 NFATC4 WNT2B FZD10 GNG13 CDH3 CDH1 WNT5B WNT5A WNT9B WNT9A WNT16 LEF1 LRP5 WNT8A WNT8B FSTL1 LRP6 WNT6 WNT11 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A ARRB1 ARRB2 PPP3CA PPP3CB AXIN1 HDAC1 PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CDH8 CELSR3 CDH7 CREBBP CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 EP300 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 FAT2 DCHS1 FAT3 PCDHB3 PCDHB7 PCDHGB7 PCDHGB6 PCDHGB2 PRKCG PCDHA8;PCDHA6-1 PRKCI PCDHGA8 PRKCH PCDHGA7 PRKCB PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PRKCE PCDHGA2 PRKCD PCDHGA1 CDHR1 PRKCA CDH10 CDH11 CDHR2 CDH12 PCDHGB1 PRKCQ CDH13 NFATC1 CDH15 CDH16 CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PCDH9 PCDH7 PRKCZ PCDH8 PCDHB15 PCDHB14 PCDHB5-1 PCDHB16 GSK3B PPP3CC SMARCAL1 SMARCB1 ARR3 GNG2 SMARCC1 SMARCC2 CSNK2A2 CSNK1D CSNK2B SRCAP NLK PPP3R1 FBXW11 HLTF SIAH2 SMARCA5 GNB1 BTRC INO80 SMARCA1 SMARCA2 SMARCA4 ANKRD6 HELLS KREMEN1 KREMEN2 CSNK2A1;CSNK2A3 CTNNA1 TBL1Y CTNNA3 CTNNA2 CSNK1A1 TLE4 CSNK1G3 TLE3 TLE2 TLE1 CHD1L TLE6 PYGO1 PYGO2 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway XDH ADA HPRT1 APRT PNP-1 PRTFDC1 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway GNB2 GNB4 GNB3 GRM3 GNB5 GRM2 SNAP29 PRKX PRKACB-1 PRKAR1B PRKAR1A VAMP8 VAMP1 VAMP2 VAMP3 GNAI1 GNAI3 PRKACA-1 GNAI2 PRKAR2B PRKAR2A GNAO1 GNB1 CACNA1B CACNA1A GNAT2 CACNB1 STX1A CACNA1E SNAP25 GNG10 ADCY10 GNG5 SNAP23 GNG4 GNG8 UNTITLED%PANTHER PATHWAY%P05916 untitled GNB2 GNB4 GNAO1 GNB3 GNB5 GNB1 AVP OXT-1 PDYN ADCY2 GNG10 OPRK1 GNAI1 GNG5 GNAI3 GNG4 ADCY7 GNG2 GNAI2 GNG8 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins PLXNA1 PLXNB1 FRK ARHGEF1 PAK1 RHOA FYN DPYSL5 DPYSL2 DPYS NRP1 RAC1 SEMA4D SEMA3A CRMP1 DPYSL4 CDK5 FES ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling PLCB3 CNR1 GNB2 GNB4 GNAO1 GNB3 GNB1 PLCB1 PLCB2 CACNA1B CACNA1A GRM1 GRM5 GNAI1 GNG5 CACNA1G GNAI3 GNG4 GNG8 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I PSMC3IP TAF1C RRN3 CAVIN1 TAF1B POLR1B TAF1A UBTF POLR1D TBP TBPL2 TAF8 TBPL1 TTF1 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides CDA TK1 ADAT2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway PRKAR2A GNB2 GNB4 GNB3 GNB5 GNB1 GNAL PRKX PRKACB-1 ADCY2 GNG10 ADRB2 GNG5 PRKACA-1 GNG4 ADCY7 GNG2 GNG8 PRKAR2B ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release GNB2 GNB4 GNB3 GNB5 PRKX PRKACB-1 CREM ADCY2 GNAI1 GNAI3 PRKACA-1 ADCY7 GNG2 GNAI2 PRKAR2B PRKAR2A OPRD1 GNAO1 GNB1 GNAL OPRM1 CREB1 PDYN PENK GNG10 GNG5 GNG4 GNG8 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCE PLCB3 PRKCD PLCB4 PRKCA ADRA1B ADRA1A PLCB1 PLCB2 ADRA2A ADRA2C ADRA2B ITPR1 PRKCG GNA11 PLCE1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 SLC25A10 ACO1 SUCLG1 ACO2 DLD ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId SLC35A2 B4GALT1 GALT UGP2 CANT1 CMPK1 SLC2A1 NME2 LALBA G6PC1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 NFKBIA IKBKB CD40LG TRAF3 TRAF6 IKBKG CD40 MAP3K1 CHUK INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS D2HGDH PC GLUD1;GLUD2 SUCLG2 L2HGDH ACO1 SUCLG1 ACO2 DLD GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway RALBP1-1 AKR1A1 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH CBR3 ABCG2 CBR1-1 NQO1 ABCC1 ABCB1 ABCC2 NOS3 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling ASNS GLUL ASRGL1 GLS2 GLUD1;GLUD2 HAL SDS CPS1 GLDC AQP8 DLD AMT TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages HRAS MAPK3 CACNA1C NFKB1 NFKBIA PRKCB ITPR1 PLCB1 CACNA1D PRKCA CACNA1F RELA MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP5K1A PIP4K2A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis SRM MAT2A ODC1 SMS AMD1 MAT2B ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway NME1 NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 RRM1 CMPK1 RRM2-1 CTPS1 TYMS DCK PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 EPHX1 CYP1A2 HYOU1 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 CYP2E1 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NQO1 COMT TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis SLC35A2 B4GALT1 GALT UGP2 CANT1 CMPK1 SLC2A1 NME2 LALBA G6PC1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP DHODH RRM2-1 UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACSS3 HSD17B10 ECHS1 ACAA2 ACAT1 ACADL ACADS HADH TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 QARS1 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCB1 ABCC2 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ADH1C;ADH1B;ADH1A RETSAT RDH8 RDH12 AWAT1 RDH11 LRAT BCO1 DGAT1 DHRS3 RPE65 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP DHODH RRM2-1 UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis DCT TYR PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism GSTZ1 YARS1 IL4I1 HPD FARSB GOT1-1 HGD PAH TAT FARSA FAH NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone ADCY2 PRKACB-1 GNGT1 CREB1 FSHR CGA PPP1CA GNAS-1 GNB1 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 ACSM2A;ACSM2B GLYAT PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) CRLS1 CDS2 PGS1 GPAM PTPMT1 GPD1 AGPAT5-1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SLC22A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ABCC2 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 TPTEP2-CSNK1E;CSNK1E CLOCK CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins PLCB1 GNGT1 TUB GNAQ CHRM1 GNB1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid EPRS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A FARSA RPL9 RPL6 RPL7 FARSB RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease PGK1 PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway GSTP1 GSTT1 ABCC4 ABCC5 SULT2A1-4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC1 ABCB1 CYP2E1 CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABCG2 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation BCKDHB MMUT PCCA PCCB DBT SDS DLD BCKDHA METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) GGH DHFR2;DHFR FTCD ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L MTHFD1 MTHFD2 MTHFR FPGS CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 ADH1C;ADH1B;ADH1A CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine AARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCB1 ABCC2 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PLA2G2A-1 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5PB ATP5MC2 ATP5F1C ATP5F1D CYCS-1 ATP5F1A SDHC ATP5F1B SDHD GPD2 SDHA UQCRC1 SDHB GAPDH-1 SLC25A4 SLC37A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 GGCX NQO1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway CYP1A2 SCN10A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SCN1B 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GLB1 GAA LCT GLA B4GALT1 GALT UGP2 PGM1 HK1 G6PC1 GALE AKR1B1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway ALDH3A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH1C;ADH1B;ADH1A CYP2E1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism ECHS1 HMGCL ACAT1 ACADS OXCT1-1 ACSM1 HADH CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway LSS SQLE ACAT1 FDPS IDI1 PMVK MVK MVD FDFT1 HMGCS1-1 HMGCR BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDIPT PGS1 JMJD7-PLA2G4B;PLA2G4B CDS1 GPAM DGKA PTPMT1 CHAT GPD1 GDE1 LYPLA1-1 CRLS1 AGPAT1 PLD2 PTDSS2 PTDSS1 PLA2G2D PCYT1A CHKA PISD PLA2G15 PHOSPHO1 PEMT PLPP1 GPD2 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C7 C9 C3-1 CFP C8A CFB CFD C5 C6 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides TYRP1 CAT SOD2 SOD3 SOD1 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 ABCG2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 TOP1 ABCC2 CES2 CES1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway SERPINC1 VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TP53 ABCC1 ABCB1 ABCC2 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway HRAS STAT5A MAPK3 STAT5B INS;INS-IGF2 IRS1 INSR SLC2A4 GHR SOCS1 RPS6KA1 GRB2 PTPN6 PLCG1 SOS1 JAK2 SHC1-1 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct ATP1A1 SLC14A2 SLC4A1 SCNN1G AQP2 ATP1B3-1 AQP3 ATP6V1B1 SCNN1D REN SCNN1B SCNN1A FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ATP1A4 ATP1A3 CA1 ATP1A2 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD2 GAPDH-1 GPD1 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine VARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 PAK1 CASP7 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD SPTAN1 MAP3K7 PAK2 DFFB MAP2K4 DAXX JUN DFFA PARP1 RIPK2 CFLAR PTPN13 FAS MAP3K1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway TUBB1 ABCG2 ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 ABCC2 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC MPC1 AGXT GPT AARS2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway SERPINC1 VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway SLC22A6 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 PTGIS DNAJB11 GPX1 ERP29 CYP2J2-1 PPIB SDF2L1 EPHX2 ALOX15 HSPA5 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 HYOU1 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SLC22A8 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC9A1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC38A4 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 AQP1 CA1 SLC4A4 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway HRAS STAT5A EPO MAPK3 FOS ELK1 EPOR MAPK8 GRB2 PTPN6 PLCG1 SOS1 JAK2 SHC1-1 JUN MAP2K2;MAP2K1 RAF1 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 OPRM1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 GPX1 ANPEP OPLAH GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease ENPP7 PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell GLP1R CACNA1A RAB3A SLC2A2 ITPR3 CAMKK1 RIMS2 ADCY10 VAMP2 RAPGEF4 GNG2 GNAQ GNB1 PLCB1 ABCC8 CACNA2D2 PRKCA CHRM3 CACNB1 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin PRKACB-1 GNGT1 CREB1 PPP1CA GNAS-1 HTR6 GNB1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 OPRM1 CYP2C9;CYP2C19 GRIN1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GRIN3A GRIN2A PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism SEPHS2 PAPSS1 MAT2A CBS;CBSL CTH AHCY MARS1 SLC39A8 METTL6 MAT2B SCLY GGT1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 ADCY2 PRKACB-1 GNGT1 GNAS-1 PTGDR GNB1 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria GSTZ1 YARS1 IL4I1 HPD FARSB GOT1-1 HGD PAH TAT FARSA FAH FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling ADCY1 PLCB1 LPAR4 SRF GNAS-1 GNG2 ROCK1 GNB1 ITPR1 AKT1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency CRAT PEX13 PEX14 ACSL1 CPT2 ABCD2 ABCD1 SLC25A20 CROT PEX11G CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease ENPP7 PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease IL4I1 ABAT ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway GSTZ1 DCT ACSS2 ALDH2 ACSS1 ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC CAT HGD MAOA HAAO MIF DBH TYR CYP2E1 COMT ALDH1B1 FAH GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC MPC1 AGXT GPT AARS2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III GALK1 GALT GCK UGP2 PGM1 UGDH GALE UXS1 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway PLCB1 VAV1 PIK3CG PIK3R6 PRKCA PLCG1 AKT1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT1 NPR1 NAMPT NMNAT3 RORA NMNAT2 CLOCK PPARGC1A SIRT1 NQO1 NADK CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin PRKACB-1 GNGT1 CREB1 PPP1CA HTR7 GNAS-1 GNB1 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PTGS2-2 SLC22A6 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC22A8 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A2 SLC6A4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B4 ATP1B1 CACNB1 PRKAR1B UQCR11 DLG1 PRKAR1A PRKAR2B KCNQ1 PRKAR2A KCNK1 MCU SLC9A1 ALG10;ALG10B SNTB1 SNTB2 PRKACB-1 GNAS-1 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway CHRNA3 CYP2A13;CYP2A6;CYP2A7-1 FMO3 CYP2B6 AOX1 CHRNA4 CHRNB2 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis TMLHE SETD7 BBOX1 ALDH9A1 SHMT1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway NME1 NME2 AK1 AK2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism CDO1 CARS1 GOT1-1 CTH GCLC LDHA GCLM MPST CTNS MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway FOS ELK1 SRF GRB2 PLCG1 PRKCB SOS1 SHC1-1 STAT6 JAK1 STAT1 EGF STAT2 STAT3 RASA1 PRKCA CSNK2A1;CSNK2A3 MAP2K2;MAP2K1 RAF1 HRAS MAPK3 MAPK8 MAP2K4 JUN EGFR MAP3K1 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism GGH DHFR2;DHFR FTCD ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L MTHFD1 MTHFD2 MTHFR FPGS FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS;CBSL CTH VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism AOX1 PDXK PNPO PDXP ALPL NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 GPX1 ANPEP OPLAH PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 MARS1 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway CDA SLC28A1 TYMP TYMS CES1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism ENPP1 ACP1 TYR FLAD1 RFK ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACSS3 HSD17B10 ECHS1 ACAA2 ACAT1 ACADL ACADS HADH ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis AGPAT1 GNPAT AGPS CEPT1 PLPP1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CHST11 BPNT1 SUOX PAPSS2 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PTGS1 ADH1C;ADH1B;ADH1A ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway NME1 NME2 AK1 AK2 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation ATP1B3-1 ATP1A1 SLC2A2 GCK FXYD2;FXYD6-FXYD2 TREH ATP1B2 SLC5A1-1 ATP1B1 ATP1A4 ATP1A3 ATP1A2 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AOX1 MAOA MAOB SLC6A4 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle SLC2A2 SLC2A4 GLUD1;GLUD2 GPT SLC38A4 GPT2 SLC1A4 SLC25A22 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway NME1 NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 RRM1 CMPK1 RRM2-1 CTPS1 TYMS DCK WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect PGK1 FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT GPI IDH3A G6PD SLC1A5 TALDO1 PGD PDHA1 IDH3G RPIA IDH1 PFKL PGAM2 ENO1 PGLS SDHC SDHD HK2 SDHA TKT GAPDH-1 SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 ACO1 SUCLG1 ACO2 DLD PKLR SLC2A2 MDH1 LDHA SLC16A1 PKM ALDOB ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) DHCR7 LBR NSDHL EBP SC5D CYP51A1 MSMO1 DHCR24 HSD17B7 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway TYK2 JAK1 STAT3 MTOR MAPK1 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway OPRM1 BCHE CES2 CES1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway RALBP1-1 HRAS MAPK3 ELK1 RAC1 CYCS-1 VAV3 BAD SMAD4 APAF1 FOXO4 RALA-1 PLD1 RHOA CASP9 CDC42 MAP2K2;MAP2K1 PIK3CA SMAD2;SMAD3 BCL2L1 CHUK AKT1 RAF1 RALGDS PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis HSD3B1;HSD3B2 CYP11B1;CYP11B2 CYP11A1 GNG2 CYP21A2 GNAQ GNB1 AGTR1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCG2 ABCB1 EGFR NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria CDO1 CARS1 GOT1-1 CTH GCLC LDHA GCLM MPST CTNS ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling ADCY1 PLCB1 LPAR5 SRF GNAS-1 GNG2 ROCK1 GNB1 ITPR1 AKT1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling HRAS PIK3CG INS;INS-IGF2 IRS1 PIK3R6 INSR PDPK1 SLC2A4 FOXO1-1 MAPK8 IRS2 GRB2 SOS1 SHC1-1 MAP2K2;MAP2K1 MAPK1 AKT1 RAF1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine LARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked CRAT PEX13 PEX14 ACSL1 CPT2 ABCD2 ABCD1 SLC25A20 CROT PEX11G ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 GPX1 ANPEP OPLAH TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System ADCY2 PRKACB-1 GNAS-1 DRD1 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway EPHX1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway RB1 PCNA GADD45B CCNB1 CCND1 CCNE1 CDK4 CDK2 BCL2 CDKN1A CDK1 E2F1 BAX APAF1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway CFD C5 C6 C7 C9 C3-1 C8A C1QB CFB C1S C1R C2 MBL2-1 SERPING1 MASP2 LOC110384692;C4A;C4B_2;C4B MASP1 C1QC MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMD4 PSMB2 PSMB3 UBD PSMB1 UBB;UBC UBE2E1 PSMC2-1 PSMA2-1 PSMA5 PSMA6 PSMC5 PSMA3 PSMA4 PSMC6 PSMC3 PSMA1 PSMC4 PSMC1 STUB1 UBA1 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 XDH CYP2E1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary GMDS FCSK FPGT PHPT1 GFUS HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway FOS ELK1 CD79B CD79A PPP3CA PPP3CB PPP3CC GRB2 BLNK RAC1 PLCG1 LYN SYK PRKCB SOS1 NFATC3 NFATC2 SHC1-1 NFATC1 CALM3;CALM1 NFATC4 BTK ORAI1 PRKCA MAP2K2;MAP2K1 RAF1 HRAS MAPK3 VAV1 MAPK8 JUN MAP3K1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling ADCY1 PLCB1 LPAR1 SRF GNG2 ROCK1 GNB1 ITPR1 AKT1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 ACAT1 OXCT1-1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism IL4I1 ABAT ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis CEPT1 PCYT1A CHKA PCYT2 PISD PEMT HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis TOP2A CAD DFFA CASP7 GZMH;GZMB-1 ENDOG HMGB2 CASP3 HMGB1-1 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKACB-1 GNGT1 PRKACA-1 ADCY10 GNAS-1 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNB1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A KARS1 RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C7 C9 C3-1 C8A C1QB C1S C1R C2 LOC110384692;C4A;C4B_2;C4B C5 C1QC C6 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NADSYN1 ENPP1 BST1 NNT NT5C2 NMRK1 NUDT12 NAMPT NMNAT2 NADK AOX1 PNP-1 NNMT QPRT SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway PTGS2-2 TOP2B PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 ABCC3 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL STAT5A SLC22A1 GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 ABCB1 CRK BCL2L1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism TPH1 ASMT KMO WARS1 INMT ALDH2 WARS2 ACMSD AANAT TDO2 KYNU AFMID CYP1A1 IDO1 AADAT DDC CAT HAAO LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation MDH1 NFKB1 ACACA NFKBIA IKBKB TRAF6 IKBKG ME1 SLC25A1 SDHC LY96 SDHD SDHA TIRAP SDHB ACLY CS CD14 TLR4 MYD88 RELA CHUK HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis ADCY2 PRKACB-1 GNGT1 FSHR GNAS-1 AVPR2 GNB1 COAGULATION%SMPDB%SMP0000586 Coagulation VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ACSS2 ADH1C;ADH1B;ADH1A CAT ALDH2 CYP2E1 ACSS1 ALDH1B1 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine GARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GLB1 GAA LCT GLA B4GALT1 GALT UGP2 PGM1 HK1 G6PC1 GALE AKR1B1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) DHCR7 LBR NSDHL EBP SC5D CYP51A1 MSMO1 DHCR24 HSD17B7 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) GSTZ1 YARS1 IL4I1 HPD FARSB GOT1-1 HGD PAH TAT FARSA FAH VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway TUBB1 ABCG2 ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 ABCC2 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT1 NAMPT TP53 NMNAT3 NMNAT2 SIRT1 NQO1 AIFM2 NADK CD38 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer FH DLST PDHB DHTKD1 MPC1 IDH3B GOT2-1 DLAT IDH3A SLC1A4 SLC1A5 PDHA1 IDH3G IDH2 SLC7A7 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 SUCLG1 ACO2 DLD LDHA ME1 SLC16A1 ACLY SLC38A5 MYCBP-1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle ATP1B3-1 ATP1A1 REN FXYD2;FXYD6-FXYD2 CLCNKA;CLCNKB ATP1B2 ATP1B1 SLC12A6 ATP1A4 ATP1A3 SLC12A1 ATP1A2 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway GGH DHFR2;DHFR FTCD ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L MTHFD1 MTHFD2 MTHFR FPGS GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline EPRS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway CXCR4 HRAS PIK3C2G MAPK3 PTK2 GNAI1 NFKB1 GNGT1 CXCL12 NFKBIA PTK2B BCAR1 PLCG1 GNAQ GNB1 MAP2K2;MAP2K1 MAPK1 CRK PXN RAF1 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway ACE REN AGT AGTR1 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 AOX1 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A MAOB ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 MAOA ATP1B2 ATP1B1 CACNB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway ALG10;ALG10B SNTB1 SNTB2 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC MPC1 AGXT GPT AARS2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAPK14 NFKB1 NFKBIA IKBKB MAPK8 MAP2K3 ATF1 MAP4K2 CRADD IKBKG TRADD TRAF2 TANK TNF CASP2 RIPK1 MAP2K7 MAP2K6 MAP2K4 JUN MAP3K1 CHUK TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids CPT1A ECHS1 HADHB-1 ACAA2 ACSL1 HADHA CPT2 ACADL SLC25A20 HADH INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway CHRNA3 CYP2A13;CYP2A6;CYP2A7-1 PCSK2 CYP2B6 AOX1 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 FMO3 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy ENPP7 PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism CNDP1 HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 AOC1 HDC PRMT3 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine IARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle SLC25A11 GOT2-1 SLC25A12 MDH2 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP DHODH RRM2-1 UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway SHMT2 MTR-1 BHMT GNMT MAT2A CHDH SARDH ALDH7A1 SHMT1 DMGDH SLC44A1 SLC44A2 MAT2B PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C7 C9 C3-1 C8A C2 MBL2-1 MASP2 LOC110384692;C4A;C4B_2;C4B MASP1 C5 C6 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway CDA SLC28A1 TYMP TYMS CES1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria MDH1 ACLY PDHB PC MPC1 SLC25A11 ME1 PDHA1 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P2RY12 ABCB1 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 ADRA1A KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HSD17B10 ECHS1 HADHB-1 ACAA2 MECR PPT1 HADHA THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP DHODH RRM2-1 UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells INPP5D MAPK14 MAP2K3 GRB2 RAC1 PLCG1 LYN SYK SOS1 TNF MAP2K7 MAP2K6 BTK GAB2 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 HRAS CSF2 MAPK8 NRAS FCER1A FYN PDK1 FCER1G IL13 PLA2G4A IL4 IL3 IL5 LCP2 KRAS MS4A2 VAV3 MAP2K4 LAT PIK3R1 PIK3CA AKT1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 L2HGDH ACO1 SUCLG1 ACO2 DLD PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia IL4I1 ABAT ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism CDO1 GAD1 CSAD ADO GGT6 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D-1 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation RB1 TP53 BTG2 CHAF1A HOXB9 BTG1 PRMT1 NGF CCND1 FGF1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium TRPC3 TRPC4 TRPV4 KCNQ2 KCNQ3 PRKG2 KCNQ4 KCNQ5 ADCY10 PRKG1 GUCY1A2 GUCY1B1 TRPC7 GUCY1A1 NOS3 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway NME1 PGK1 NT5C SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SLC22A1 SLC22A2 ABCC4 PCYT1A SLC22A3 ABCG2 CHPT1 ABCC3 PCYT2 CMPK1 ABCC1 ABCB1 ABCC2 DCK VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A2 SLC6A4 ABCB1 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) GALK1 GALT GCK UGP2 PGM1 UGDH GALE UXS1 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway CYP2C9;CYP2C19 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway PTGS2-2 TOP2B PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 ABCC3 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification SLC2A4 PNP-1 SLC2A1 AS3MT GSTO1 AQP9 LOC100509620;LOC112267859;AQP7 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) GSTZ1 YARS1 IL4I1 HPD FARSB GOT1-1 HGD PAH TAT FARSA FAH HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine RPL4 SARS1 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling ADCY1 PLCB1 SRF GNG2 ROCK1 GNB1 ITPR1 AKT1 LPAR2 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 NR1H4 SLC10A2 FGFR4 FGFR3 FGFR2 FGFR1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SNTB1 ABCC8 SNTB2 CACNA1A SLC2A2 CACNA2D2 GCG SCN5A SNTA1 CACNB1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria GMDS FCSK FPGT PHPT1 GFUS HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids CRAT PEX13 PEX14 ACSL1 CPT2 ABCD2 ABCD1 SLC25A20 CROT PEX11G INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin ADCY2 PRKACB-1 GNGT1 PTGIR MYL3 GNAS-1 MYLK GNB1 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 MAPK14 NFKB1 NFKBIA IKBKB TRAF6 IKBKG ECSIT RELA IRAK1 TLR1 TOLLIP TLR9 TAB3 TLR8 TAB2 TLR7 TAB1 TLR6 MAPK8 TLR5 TLR3 TLR2 MAP3K7 LY96 MAP2K4 TIRAP CD14 TLR4 MYD88 MAP3K1 CHUK GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 ABCG2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 TOP1 ABCC2 CES2 CES1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis PANK1 ENPP1 VNN1 PPCS COASY PPCDC METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine ELK1 PRKACB-1 GNGT1 NFKB1 PDPK1 NFKBIA CREB1 IKBKB RPS6KA1 GNAS-1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS MAPK8 PAK1 ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 MAPK11 ADORA2A JUN RAPGEF2 ARHGEF7 RAPGEF3 CDC42 PIK3CA MAP3K1 AKT1 CHUK ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor PLCB1 PRKCA GNAQ ITPR1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary GGH DHFR2;DHFR FTCD ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L MTHFD1 MTHFD2 MTHFR FPGS SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HSD17B10 ECHS1 HADHB-1 ACAA2 MECR PPT1 HADHA ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 TARS1 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism GALK1 GALT GCK UGP2 PGM1 UGDH GALE UXS1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TP53 ABCC1 ABCB1 ABCC2 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 ADRA1A KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia CNDP1 HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 AOC1 HDC PRMT3 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PDE4D-1 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids ECHS1 HADHB-1 ACAA2 HADHA ACSM1 ACADM SLC25A20 HADH ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CHST11 BPNT1 SUOX PAPSS2 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism HSD11B1 PDIA2 UGT1A1;UGT1A6 PDIA6 CYP11B1;CYP11B2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 SRD5A1 HSD17B3 AKR1D1 CYP19A1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 SLC25A10 ACO1 SUCLG1 ACO2 DLD BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway VEGFA KDR FLT1 NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway HYOU1 OPRM1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 CEPT1 CHKA PCYT2 PISD METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A YARS1 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism IPPK PIKFYVE MIOX ISYNA1 INPP1 ITPK1 IPMK PI4KA INPP4A MINPP1 IMPA1 PIK3C3 ITPKA INPP5J PLCD3 VAC14 BECN1 PIK3R4 AMBRA1 PIK3CA PTPMT1 FIG4 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway HSD17B10 HADHB-1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ACADSB HADHA CYP2B6 ACSM1 IVD EHHADH-1 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid DARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance ATP1B3-1 ATP1A1 LCT SLC2A2 FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1B1 ATP1A4 ATP1A3 ATP1A2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SNTB1 SNTB2 SCN5A SNTA1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 ALDH1A1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway ERBB4 NRG2 PSEN1 PRKCA ADAM17 EGFR ERBB3 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway RALBP1-1 PAK1 PCNA RAC1 CCND1 CDKN1A CAP1 VAV3 PDGFRA WASF1-1 LIMK1 CCND3 CDK5 PLD1 ACTB-1 MYLK RPS6KB1 MYL2 CFL1 ARFIP2 PPP1R12B MAP3K1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS;CBSL CTH KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis PGK1 PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) ENPP7 PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway NFKB1 NFKBIA IKBKB TRAF6 IKBKG TRADD TNF RIPK1 RELA IRAK1 CAMKK2 IL1R1 NCOA3 TNFRSF1B TNFRSF1A IL1A TAB1 MAP3K14 CAMKK1 UBB;UBC FADD MAP3K7 TLR4 MYD88 MAP3K1 CHUK METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB-1 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CYP2B6 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR SST HRH2 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS2 ELOVL4 ELOVL5 FADS1 JMJD7-PLA2G4B;PLA2G4B OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 GPX1 ANPEP OPLAH KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease ENPP7 PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism MTR-1 BHMT MAT2A CHDH ALDH7A1 PEMT AHCY MAT2B BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A CARS1 RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC MPC1 AGXT GPT AARS2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IMPDH1 IMPDH2 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 ABCC2 CES2 CES1 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ADH1C;ADH1B;ADH1A RETSAT RDH8 RDH12 AWAT1 RDH11 LRAT BCO1 DGAT1 DHRS3 RPE65 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency GSTZ1 DCT ALDH3A1 PNMT GOT1-1 AOC1 ADH1C;ADH1B;ADH1A DDC HGD MAOA HAAO MIF DBH TYR COMT FAH CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P2RY12 ABCB1 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis CYBA DUOX2 SLC5A5 DUOX1 TPO TG NOX3 CYBB NOX4 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine ELK1 PRKACB-1 GNGT1 NFKB1 PDPK1 NFKBIA CREB1 IKBKB RPS6KA1 GNAS-1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS ADCY2 MAPK8 PAK1 ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 ADORA2B MAPK11 JUN RAPGEF2 ARHGEF7 RAPGEF3 CDC42 PIK3CA MAP3K1 AKT1 CHUK FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome PGK1 PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 SST LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling PIK3CG INS;INS-IGF2 IRS1 PIK3R6 INSR IRS2 SLC7A5 TSC2 TSC1 RHEB EIF4EBP1 MTOR EIF4E RPS6KB1 AKT1 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency DHFR2;DHFR CBR1-1 PTS QDPR GCHFR SPR GCH1 AKR1B1 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 ACAT1 OXCT1-1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling P4HA3 TLR4 IL1B NLRP3 HIF1A SIRT3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 OPRK1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin PRKACB-1 GNGT1 CREB1 PPP1CA GNAS-1 GNB1 HTR4 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A1 HYOU1 HSD17B1 COMT MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway CALML6 ADCY1 LHB CAMK2A ELK1 GNA11 MAPK14 GNRHR MAP3K2 EGR1 CGA MAP2K3 MMP2 FSHB ACTN4 GNAS-1 GRB2 MMP14 GNRH1 PRKCB SOS1 HBEGF ATF4 ITPR1 PLCB1 MAP2K7 CACNA1D PRKCA CACNA1F JMJD7-PLA2G4B;PLA2G4B MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 HRAS CACNA1C PRKACA-1 MAPK8 JUN CACNA2D2 PLD1 CACNB1 CDC42 EGFR MAP3K1 SRC TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 FOS ELK1 MAPK14 NFKB1 NFKBIA IKBKB MAP2K3 TRAF6 IKBKG EIF2AK2 PPARA MAP2K6 ECSIT RELA IRAK1 TOLLIP TLR9 TAB2 TLR7 TAB1 MAPK8 TLR3 TLR2 MAP3K7 LY96 MAP2K4 TIRAP JUN CD14 TLR4 MYD88 MAP3K1 CHUK CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis CRLS1 CDS2 PGS1 GPAM PTPMT1 GPD1 AGPAT5-1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway FOS ELK1 NFKB1 NFKBIA PPP3CA PPP3CB PPP3CC GRB2 RAC1 PLCG1 PRKCB SOS1 NFATC3 NFATC2 SHC1-1 NFATC1 CD3G CALM3;CALM1 CD3E NFATC4 CD3D RASGRP1 ZAP70 LCK PTPN7 CD247 PRKCA RELA MAP2K2;MAP2K1 RAF1 HRAS MAPK3 VAV1 PIK3CG MAPK8 FYN UBB;UBC MAP2K4 LAT JUN PIK3R1 PIK3CA MAP3K1 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 XDH TPMT ADK PPAT RAC1 SLC28A2 SLC29A2 HPRT1 IMPDH1 AOX1 GMPS FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNA1C CACNA2D2 CACNB1 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PTK2B P2RY2 PRKCA PLCG1 PRKCB MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type SRM IL4I1 BHMT MTAP MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) DCTD NT5C2 RRM2B CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP DHODH RRM2-1 UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway CALM3;CALM1 NOS1 PRKACB-1 GRIN1 GRIN3A PPP3CA XDH DLG4 PRKCA ALDH2 GRIN2A ITPR1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia AOX1 PDXK PNPO PDXP ALPL PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP5K1A PIP4K2A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic CDO1 CARS1 GOT1-1 CTH GCLC LDHA GCLM MPST CTNS BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) NR1H4 SLC10A2 ABCC4 GPBAR1 SLCO1A2 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids CRAT PEX13 PEX14 ACSL1 CPT2 ABCD2 HACL1 ALDH2 PHYH-4 ABCD1 SLC25A20 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway SERPINC1 VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome SLC35A2 B4GALT1 GALT UGP2 CANT1 CMPK1 SLC2A1 NME2 LALBA G6PC1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism ENPP7 PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 B4GALT6 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production PRKACB-1 GNGT1 POMC GNAS-1 MC2R GNB1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling ADCY1 SRF GNAS-1 GNG2 ROCK1 LPAR6 GNB1 AKT1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation GMDS FCSK FPGT PHPT1 GFUS HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP7A1 CYP8B1 LIPA CYP39A1 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 GPX1 ANPEP OPLAH CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine HARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SLC6A2 SLC6A4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin LHB ADCY2 PRKACB-1 GNGT1 CREB1 CGA PPP1CA GNAS-1 GNB1 LHCGR LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation ATP1B3-1 ATP1A1 LCT SLC2A2 FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1B1 ATP1A4 ATP1A3 ATP1A2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis LPIN1 AGPAT1 GPAM DGAT1 GPD1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS;CBSL CTH HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway ACE REN AGT GNG2 GNAQ GNB1 AGTR1 CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation ALDH8A1 DLST DHTKD1 ACMSD DLD BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 WARS1 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism INPP4B IPPK NUDT3 ISYNA1 PPIP5K1 INPP1 IP6K1 ITPK1 IPMK INPP4A MINPP1 IMPA1 ITPKA INPP5J ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway SERPINC1 VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule ATP1A1 SLC8A1 TRPV5 CLCNKA;CLCNKB SLC12A3 AQP2 ATP1B3-1 AQP3 REN FXYD2;FXYD6-FXYD2 ATP1B2 ATP4B ATP1B1 ATP1A4 ATP4A ATP1A3 ATP1A2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation MAPK3 NFKB1 CREB1 SUCNR1 IKBKB IKBKG PLCB1 MAPK11 PTGS1 PRKCA MAPK1 CHUK NOS3 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 PNP-1 GART RRM2-1 ITPA ADA D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway PRF1 ARHGAP5 ARHGAP32 CASP8 CASP1 CASP10 CASP3 ARHGDIB CYCS-1 JUN APAF1 PARP1 GZMH;GZMB-1 CASP9 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSS GSR GCLC CASP7 GGCT GCLM GGT6 GSTO2 GPX1 ANPEP OPLAH ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway PTGES PTGS2-2 PTGIS GPX1 CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine NARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine ADCY2 PRKACB-1 GNGT1 CREB1 PPP1CA GNAS-1 GNB1 HRH2 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis LSS ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 MSMO1 DHCR24 HMGCR HSD17B7 LIPA LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling ADCY1 PLCB1 GNAS-1 GNG2 LPAR3 GNB1 ITPR1 AKT1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260211%WP4236%HOMO SAPIENS Krebs cycle disorders PDHX FH DLST GPT DHTKD1 LDHB LDHA;LDHC LDHA SUCLA2 MPC1 SUCLG2 SUCLG1 PCK2 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260211%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes COL9A2 MATN3 COMP MATN1 COL9A1 COL9A3 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260211%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor TGFB2 TGFB1 TGFB3 STAT3 FN1 ACTA2 MAPK10 COL1A1 MAPK9 MAPK8 SMAD2;SMAD3 ENPP2 RHO CCN2 PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260211%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway HSPA1A;HSPA1B UBE2L6 PSMD8 TUBA1C PSMD9 PSMD6 PSMD7 TUBA1A CASP8 PSMD4 PSMD5 RNF19A PSMD2 TUBB1 PSMD3 CASP1 PSMD1 GPR37 TUBB2B;TUBB2A FBXW7 CASK PSMC2-1 TUBA4A CCNE1 TUBB3;TUBB6 PSMD10 PRKN PSMD12 PSMD11 TUBAL3 PSMD14 PSMD13 CUL1 HSPA14 UBE2J2 UBE2J1 TUBA3E;TUBA3C-1 SNCA HSPA9 HSPA8 HSPA5 HSPA1L HSPA4 SIAH2 SIAH1 HSPA6 SEPTIN5 UBE2G1 HSPA2 UBE2G2 SNCAIP TUBB4B PSMC5 PSMC6 PSMC3 PSMC4 TUBB4A;TUBB;TUBB8B;TUBB8 PSMC1 UBA1 STUB1 TUBA8 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260211%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation CRTC2 FLT1 PDGFA TGFBR1-1 FOXM1 IGF1R INS;INS-IGF2 RASSF1 AKT2 MYC AKT3 MAPK1 AKT1 MAPK3 INSR PDX1 BRAF FOXO1-1 IGF1 DLK1 PGF SMAD7 CDK4 CDK2 KRAS MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260211%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways ACTA2 ATF1 ATF2 MYLK2 OXTR CRCP GABPB1 RXFP1 RXFP2 ETS2 SLC8A1 ACTG1 RGS4 RGS5 RGS2 GJA1 RGS3 RGS1 RGS9 RGS6 RGS7 PRKCG IGFBP1 GUCY1A1 PRKCH IGFBP5 IGFBP4 PRKCB IGFBP3 PRKCE PRKCD IGFBP2 PRKCA DGKZ GNAS-1 MYL4 CACNB3 ADCY9 PRKAR1B PRKAR1A MYL2 PRKCQ PRKD1 ATF5 ATF3 ATF4 CALCA ITPR1 LPAR1 ITPR2 ITPR3 PRKCZ CRHR1 CNN2 CNN1 GRK5 PRKAR2B GRK4 CALD1 PRKAR2A GRK6 PLCG2 SFN PLCG1 IGFBP6 JUN PDE4D-1 NFKB1 GNG13 PKIB IL6 SP1 GNB2 GNAQ ACTB-1 PKIA GPR182 MAFF GNB1 GNB4 GNB3 GNB5 PKIG CALM1 CALM2 ACKR3-2 RYR1 YWHAE RYR2 ACTC1;ACTG2 YWHAB ATP2A3 ATP2A2 ARRB1 ADM ARRB2 RYR3 GNGT1 PRKACA-1 YWHAQ PDE4B NOS1 GABPA YWHAG YWHAH GSTO1 FOS YWHAZ CREB3 ACTA1 PLCB3 CREB1 IL1B CRH RGS18 CAMK2B RGS17 RAMP2 CAMK2D RAMP3 RGS19 ATF6B RGS14 RGS16 CAMK2A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 GNG2 GNG5 GNG4 RGS20 GNG8 RLN2;RLN1 CAMK2G CORIN NOS3 GUCA2B OXT-1 CALM3;CALM1 GUCA2A RGS10 RGS11 RAMP1 PLCD1 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome CEP19 HFE SLC40A1 PIGZ TGFB1 CASP7 SENP5 H2BC21 UBXN7 MAD2L1BP-1 SMCO1 DYNC2H1 PCYT1A NCBP1 DYNLT1 ADAM10 SLC51A SLC51B SIRT1 FNDC8 PIGM GRIA1 DYNLT2B PXN MYCBP2 RNF168-1 RNF8 PIK3R3 FBXO45 HIF1A DYNC2LI1 BRINP1 PAK2 STAT5A STAT5B TM4SF19 FBXW7 CEP350 MCRS1 PIGX-1 JUN WDR53 ZNF76 RABL2A;RABL2B DLG1 NCBP2-1 TF UBE2N DYNLRB2 NF2 DYNLRB1 MELTF HAMP CEP43 MYC DYNC2I2 DYNC2I1 NRROS TFRC ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260211%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects MAPK10 MAPK9 MAPK8 PSMD8 TUBA1C PSMD9 PSMD6 PSMD7 TUBA1A CASP8 PSMD4 PSMD2 TUBB1 PSMD3 PSMD1 TUBB2B;TUBB2A PSMC2-1 TUBA4A TUBB3;TUBB6 PSMD12 TUBAL3 PSMD14 PSMD13 TUBA3E;TUBA3C-1 SNCA TUBB4B PSMC5 PSMC6 PSMC3 PSMC4 TUBB4A;TUBB;TUBB8B;TUBB8 PSMC1 TUBA8 INS;INS-IGF2 AKT2 AKT3 MAPK1 AKT1 MAPK3 INSR BRAF KRAS ATF4 ITPR1 ITPR2 ITPR3 NFKB1 IL6 GNAQ CALM1 CALM2 ATP2A3 ATP2A2 RYR3 NOS1 PLCB3 IL1B CALM3;CALM1 CASP7 ADAM10 PIK3R3 APP CALML6 ARAF CALML3 FZD10 CALML4 FRAT2 CSNK2A2 ATG14 DKK1 ATG13 DKK2 DKK4 SFRP4 DDIT3 CSNK2B VDAC3 ULK2 ULK1 VDAC1 ATF6 PTGS2-2 PIK3R4 PIK3R2 PIK3R1 APH1A NCSTN GRIN2A PPP3R1 APH1B FADD NRBF2 APOE FZD1 WNT10B WNT10A FZD3 XBP1 FZD2 FZD5 FZD7 FZD6 EIF2AK3 FZD9 EIF2AK2 FZD8 GRIN2C GRIN2B GRIN2D ATG2A NOX4 NOX1 ATG2B IDE IKBKB PPP3CA PPP3CB PPP3CC HRAS PSENEN APC2 MME BACE1 PSMA5 IL1A PSMA6 PSMA3 PLCB4 PSMA4 PSMA1 MAPT CSNK2A1;CSNK2A3 PLCB1 PLCB2 PSMA7 RELA PSMA8 CYCS-1 PSMB6 PSMB7 NRAS PSMB4 MAP2K2;MAP2K1 PSMB5 PSMB2 PSMB3 PSMB1 APBB1 BID CSNK1A1 WNT7B WNT7A GRIN1 PSMA2-1 FAS CTNNB1 CDK5R1 CSF1 IRS1 IRS4 IRS2 TNF VDAC2-1 KIF5C KIF5B KIF5A CAPN2 CAPN1 MAP3K5 WNT5B WNT5A CYBB ERN1 ADAM17 PPIF RAF1 PPID RTN3 PSEN2 LPL CACNA1D GPR83 CACNA1C PSEN1 CACNA1F KLC1 AGER RTN4 KLC4 WNT6 KLC3 KLC2 ATG101 DVL1 DVL2 DVL3 NAE1 CACNA1S MAP2K7 WNT1 WNT2 WNT3 WNT4 WNT3A EIF2S1 SEM1 CDK5 TPTEP2-CSNK1E;CSNK1E MCU GSK3B WNT2B PIK3CD ATP2A1 PIK3CB CASP9 GAPDH-1 RB1CC1 CASP3 CHUK APAF1 AXIN1 TRAF2 WIPI1 WIPI2 AXIN2 WNT16 TNFRSF1A PIK3CA PIK3C3 SLC25A5 SLC25A4 SLC25A6 BECN1 LRP1 BECN2 LRP5 CHRNA7;CHRFAM7A AMBRA1 HSD17B10 LRP6 WNT11 NOS2 BAD ADRM1 MTOR APC SLC25A31 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260211%WP2249%HOMO SAPIENS Metastatic brain tumor E2F3 TP53 MYC PIK3R1 CDC42 CDK6 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260211%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging SIRT1 TFAM-1 PARP1 NAMPT PPARG FOXO3 ROS1 NFKB1 SIRT3 HIF1A FOXO1-1 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5365%HOMO SAPIENS 4p16 3 copy number variation NELFB FAM53A NELFCD NELFA H3-3A NELFE POLN GAB1 FRS2 BCS1L CKAP5 PIK3R1 LETM1 TACC3 C4orf48 GRB2 SOS1 NAT8L FGFR3 MAPK1 MAPK3 PLCG1 UBE2J2 SLBP CBL FGF2 ERI1 CLTCL1 NSD2 TMEM129 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260211%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MEF2A MYOCD MEF2C CCND2 SRF NKX2-5 KLF4 MEF2D MEF2B;BORCS8-MEF2B CAMK2D ELK1 MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260211%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CTCF MSMP CCR2 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260211%WP5548%HOMO SAPIENS Blood based neuroinflammation markers CCL13;CCL2 GRN CCL11 BDNF ADM TREM2 TREM1 CX3CL1 GFAP CCL5 CCL23;CCL15 OLR1 IL6 CHI3L1 TSPO NEFL TAC1 IL1B TNF CRP FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260211%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 LPL CETP EPHX2 APOA2 PCSK9 APOA1 LCAT APOA4 USF1 GHR LIPC APOB LDLRAP1 LDLR PLTP GPIHBP1 LUPUS THERAPIES%WIKIPATHWAYS_20260211%WP5560%HOMO SAPIENS Lupus therapies CD40 IL25 CD80 TNFSF13B C2 CD19 CD38 IL12B IL12A LOC110384692;C4A;C4B_2;C4B IL6R C3-1 CD40LG IFNG IL23A CD28 IL17F IL17D IL17C MS4A1 IL17B CD22 C1QC IL17A IL6 CD86 C1QB EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260211%WP5443%HOMO SAPIENS Effects of MFN2 mutation SYPL1 MAP2 BAX MFN2 KIF1B RABAC1 DYNC1I1 RAB7A TUBB3;TUBB6 DYNC2H1 CASP3 TP53 SNCA RAB3B CASP8 DYNC1H1 RAB3A DCTN1 DYNC2I2 TRAK1 DYNC2I1 ATAT1 DYNC1LI2 RHOT1 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260211%WP5124%HOMO SAPIENS Alzheimer 39 s disease MAPK10 MAPK9 MAPK8 PSMD8 TUBA1C PSMD9 PSMD6 PSMD7 TUBA1A CASP8 PSMD4 PSMD2 TUBB1 PSMD3 PSMD1 TUBB2B;TUBB2A PSMC2-1 TUBA4A TUBB3;TUBB6 PSMD12 TUBAL3 PSMD14 PSMD13 TUBA3E;TUBA3C-1 SNCA TUBB4B PSMC5 PSMC6 PSMC3 PSMC4 TUBB4A;TUBB;TUBB8B;TUBB8 PSMC1 TUBA8 INS;INS-IGF2 AKT2 AKT3 MAPK1 AKT1 MAPK3 INSR BRAF KRAS ATF4 ITPR1 ITPR2 ITPR3 NFKB1 IL6 GNAQ CALM1 CALM2 ATP2A3 ATP2A2 RYR3 NOS1 PLCB3 IL1B CALM3;CALM1 CASP7 ADAM10 PIK3R3 APP CALML6 ARAF CALML3 FZD10 CALML4 FRAT2 CSNK2A2 ATG14 DKK1 ATG13 DKK2 DKK4 SFRP4 DDIT3 CSNK2B VDAC3 ULK2 ULK1 VDAC1 ATF6 PTGS2-2 PIK3R4 PIK3R2 PIK3R1 APH1A NCSTN GRIN2A PPP3R1 APH1B FADD NRBF2 APOE FZD1 WNT10B WNT10A FZD3 XBP1 FZD2 FZD5 FZD7 FZD6 EIF2AK3 FZD9 EIF2AK2 FZD8 GRIN2C GRIN2B GRIN2D ATG2A NOX4 NOX1 ATG2B IDE IKBKB PPP3CA PPP3CB PPP3CC HRAS PSENEN APC2 MME BACE1 PSMA5 IL1A PSMA6 PSMA3 PLCB4 PSMA4 PSMA1 MAPT CSNK2A1;CSNK2A3 PLCB1 PLCB2 PSMA7 RELA PSMA8 CYCS-1 PSMB6 PSMB7 NRAS PSMB4 MAP2K2;MAP2K1 PSMB5 PSMB2 PSMB3 PSMB1 APBB1 BID CSNK1A1 WNT7B WNT7A GRIN1 PSMA2-1 FAS CTNNB1 CDK5R1 CSF1 IRS1 IRS4 IRS2 TNF VDAC2-1 KIF5C KIF5B KIF5A CAPN2 CAPN1 MAP3K5 WNT5B WNT5A CYBB ERN1 ADAM17 PPIF RAF1 PPID RTN3 PSEN2 LPL CACNA1D GPR83 CACNA1C PSEN1 CACNA1F KLC1 AGER RTN4 KLC4 WNT6 KLC3 KLC2 ATG101 DVL1 DVL2 DVL3 NAE1 CACNA1S MAP2K7 WNT1 WNT2 WNT3 WNT4 WNT3A EIF2S1 SEM1 CDK5 TPTEP2-CSNK1E;CSNK1E MCU GSK3B WNT2B PIK3CD ATP2A1 PIK3CB CASP9 GAPDH-1 RB1CC1 CASP3 CHUK APAF1 AXIN1 TRAF2 WIPI1 WIPI2 AXIN2 WNT16 TNFRSF1A PIK3CA PIK3C3 SLC25A5 SLC25A4 SLC25A6 BECN1 LRP1 BECN2 LRP5 CHRNA7;CHRFAM7A AMBRA1 HSD17B10 LRP6 WNT11 NOS2 BAD ADRM1 MTOR APC SLC25A31 ALSTROM SYNDROME%WIKIPATHWAYS_20260211%WP5202%HOMO SAPIENS Alstrom syndrome CEP19 RILPL1 IFT81 MYO5B GPR161 ALMS1 IFT27 VCP-1 E2F4-1 RABL2A;RABL2B IFT172 HSPB11 BLOC1S4 VCPIP1 IFT74 BLOC1S6 BLOC1S1 STX5 CEP192 SNAPIN PTCH1 PIFO RFX2 DTNBP1 RFX3 RFX1 ACTN4 TUBG1 ARMCX5-GPRASP2;GPRASP2 DNM3 NSFL1C SMO TFDP2 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260211%WP4725%HOMO SAPIENS Sphingolipid metabolism overview ASAH1 CERK SGMS1 GBA SGMS2 GBA2 UGT8 UGCG SGPL1 SPTLC1 SMPD1 KDSR CERS3 CERS4 CERS6 SPHK2 SPHK1 SGPP2 SGPP1 DEGS1 DEGS2 PLPP3 PLPP2 PLPP1 CERS1 CERS2 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260211%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SMAD4 TNC RUNX2 CDH6 CDH2 FN1 CDH1 ID1 SNAI1 SNAI2 VIM CDH16 SMAD2;SMAD3 AKT2 AKT3 MAPK1 AKT1 MAPK3 VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260211%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression GCLC KCNQ2 BCL2 KCNQ3 PVALB NFE2L2 GRIN2A GRIN1 ITPR1 ITPR2 ITPR3 GRIN2C GRIN2B GRIN2D TPH2 TPH1 CACNA1C KDM3A CHRM1 SLC8A1 KDM1A KDM1B CYP27B1 GRM5 CALB1 RXRA GGT1 KDM6B G6PD VDR GSR ATP2B4 ATP2B3 ATP2B2 ATP2B1 CYP27A1 VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260211%WP3871%HOMO SAPIENS Valproic acid pathway ACADSB HSD17B10 HADHA HADHB-1 CYP2B6 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 HDAC1 IVD EHHADH-1 ACSM1 ABAT FERROPTOSIS%WIKIPATHWAYS_20260211%WP4313%HOMO SAPIENS Ferroptosis COQ2 LPCAT3 SLC40A1 CTH GCLM VDAC2-1 CYBB TF GCLC VDAC3 STEAP3 CISD1 HSPB1 SAT2 SLC7A11 SAT1 BACH1 MAP1LC3A CBS;CBSL MAP1LC3C AIFM2 FTH1 SLC39A8 MAP1LC3B2;MAP1LC3B-1 SLC38A1 GPX4 ACSL1 SLC11A2 NCOA4 ACSL6 ACSL5 NOX4 ACSL4 NOX1 ACSL3 SLC39A14 POR CHMP6 CHMP5 ALOX15 IREB2 SLC3A2 HMGCR SLC1A5 TP53 DPP4 FTMT PCBP1 PCBP2 PHKG2 HMOX1 ATG7 FDFT1 ATG5 PRNP FTL-1 GCH1 GSS TXNRD1 TFRC CP SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260211%WP2267%HOMO SAPIENS Synaptic vesicle pathway SNAP25 CLTC CLTA AP2A1 PARK7 AP2A2 SLC6A4 RIMS1 DNM1L SLC18A1 SLC18A2 AP2M1 SLC18A3 UNC13B NSF UNC13C UNC13A SLC32A1 SYP SYN3 SYN2 SYN1 DNM1 DNM2 VAMP2 STX1A NAPA SLC22A3 STXBP1 CACNA1B SLC1A3 CACNA1A ATP1A2 CPLX2 CLN8 CPLX1 CPLX3 AP2S1 SLC17A6 SLC17A7 STX3 SLC17A8 STX2 SYT1 AP2B1 RAB3A SLC25A4 SLC38A1 DNM3 CLTCL1 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260211%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming HDAC1 ANKRD13C FTO CREBBP DNMT1 HDAC2 IRS1 GGT6 YTHDF3 CADM1 DNMT3A TET2 NOL9 IFITM3;IFITM2;IFITM1 PIP4K2A EP300 EZH2 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260211%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis SREBF1 CEBPA DDIT3 CEBPB EGR2 CEBPD CEBPG GATA3 GATA2 KLF15 KLF2 KLF5 PPARG ROTENONE METABOLISM%WIKIPATHWAYS_20260211%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260211%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins ULK1 PRKAA2 CALCOCO2 PPP1R9A RPTOR RB1CC1 DEPTOR LAMP2 MLST8 VPS11 VPS39 EIF4B VPS16 ATG3 VPS18 AKT1 GABARAPL2 OPTN-1 VPS33A RPS6 ATG9A MAP1LC3B2;MAP1LC3B-1 LARP1-1 VAMP8 TMEM59 ATG12-1 PKM RPS6KB1 RHEB ATG16L1 AKT1S1 VPS41 ATG2B RAB7A NBR1 TAX1BP1 ATG4A MTOR LAMTOR1 SQSTM1 ATG7 APOB ATG5 ATG13 INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260211%WP1984%HOMO SAPIENS Integrated breast cancer pathway SMAD2;SMAD3 RHO SIRT1 MYCBP2 CASP8 GRN ARAF EP300 PIK3R2 TGFBR1-1 FADD MYC MAPK1 AKT1 BRAF FOXO1-1 SMAD7 BAX CDK4 RHEB CDK2 KRAS ATF1 RB1 MRE11 NAB1 MAP3K7CL AHR STK11 ZMYND8-1 CCND1 ZMIZ1 CHEK2 ALKBH1 CHEK1 DAG1 RPP38 RALGAPA1 TSC2 TSC1 CSNK1D PPP4R3A PPP4R3B RALA-1 MYT1 CCNB1IP1 CDC25A CDC25B PIAS1 MSH6 CERK EDAR AR MSH2 BLM BID MAX MDM2-2 PHB CYP19A1 RASGRP3 RAP1A RRAS CTNNB1 NUP85 TPR IRS1 ABL1 BARD1 UBE2F SMAD1 PLK3 GADD45A PLK1 XRCC3 ERAL1 SMAD6 ESR1 SMARCA4 SMAD4 FOSL2 FOSL1 CDK7 FER NOXA1 CDH1 JUN NF1 ATM NFKB1 TAB1 ZNF655 MAP3K13 BMPR1A SP1 ATR PIGR GSK3A BMPR2 PKIA USP38 GDI1 TRADD PTEN BRCA1 BRCA2 IMPA1 RASGEF1A RAC1 JAK1 ANXA1 MMP1 NCOA3 DCAKD TGFBR2 ITPKC USP15 USP16 BCL2 ODC1 SELENOK TFPI JAKMIP1 EGFR AURKA PAK1 E2F1 RAD54L HDAC1 BAK1 STAT1 CASP9 USP21 PML VEGFA CASP3 HIPK2 CHUK RAD50 WEE1 RAD51 CREB1 FILIP1 FAU BACH1 BAD MTOR CDC42 HMGCR TP53 DHTKD1 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260211%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS BCL2 MAP2K2;MAP2K1 NOS1 BID CASP9 CASP3 APAF1 GRIA1 TOMM40 SLC1A2 DERL1 TNF CST3 TNFRSF1A NEFM NEFH MAP2K6 PRPH DAXX CASP1 MAP3K5 GPX1 MAPK14 SOD1 CCS BAX ALS2 CAT SMIM40 RAB5A BCL2L1 BAD PPP3CA PPP3CB PPP3CC NEFL TP53 RAC1 VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260211%WP1533%HOMO SAPIENS Vitamin B12 metabolism CBLIF MMAB MTHFR CTH SOD2 SOD3 HBA2;HBA1 NFKB2 TCN2 TCN1 ALB TNF CRP CCL13;CCL2 CCL5 NFKB1 IL6 APOA1 APOB LDLR IFNG INS;INS-IGF2 APOE IL1B CBS;CBSL INSR SOD1 SCARB1 SERPINA3 MTRR SERPINE1 PLAT MTR-1 MPO ICAM1 MCEE SAA2;SAA1 MMUT FGB CUBN FGA SAA2-SAA4;SAA4 FGG MAT1A F2 F7 SHMT2 PLG LRP2 HBD;HBB RELA ABCA1 AMINO ACID METABOLISM%WIKIPATHWAYS_20260211%WP3925%HOMO SAPIENS Amino acid metabolism CTH GCLM PNMT GOT1-1 ADH1C;ADH1B;ADH1A HIBADH TAT DBH HNMT FTCD GLS AUH TDO2 PDK4 HMGCS2 ACADM HADH GLUL HIBCH ARG2 SDS RARS1 ARG1 GPT2 MARS2 MCCC1 CAD SDHA LARS2 ACLY ALDH1A1 SMS BCAT1 ALDH7A1 DLD GOT2-1 DDC TPH1 OAT PPM1L MAOA HDC ADH5 SRM HMGCL ADH4 TPO IARS1 PCK1 ACSS1 VARS1 AOC3 GSR MPST PDHA1 MDH1 MDH2 IDH1 ACAA1-1 PYCR1 ODC1 ASNS FAH ASS1 WARS1 GLUD1;GLUD2 CS HAL G6PC2 BHMT PC CPS1 EHHADH-1 TH EPRS1 P4HA2 OGDH ACO2 ALDH18A1 FARSB OTC CBS;CBSL PKM PDHX FH DLST MMUT LDHA SUCLG1 GSS KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260211%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence AFMID IDO2 TLR4 IDO1 CAT KLF5 NOS1 IFNG AHR TP53 TDO2 CDKN1A IFNB1-4 AADAT IL1R2 TNF EIF2AK1 HAAO QPRT EIF2AK4 KMO FOXO1-1 ACMSD KYNU PROLACTIN SIGNALING%WIKIPATHWAYS_20260211%WP2037%HOMO SAPIENS Prolactin signaling PTK2 NFKBIA TEC PTPN6 NFKBIB MAP2K2;MAP2K1 STAT3 SHC1-1 MAPK9 MAPK8 GRB2 SOS1 IRS1 PXN IRS2 ELK1 STAT5A STAT5B RAF1 JUN NFKB1 RAC1 JAK1 GSK3B PAK1 PIK3R2 PIK3R1 PIK3CB YWHAG STAT1 FOS CASP3 YWHAZ MYC MAPK1 AKT1 PIK3CA MAPK3 RPS6 MAPK14 RPS6KB1 ITGB1 PRL PIK3CG RPS6KA2 NEK3 JAK2 CTSD PIAS3 MTOR CISH HRAS GAB2 PRLR VAV1 VAV2 ZAP70 PPIB PPIA SRC AGAP2 SIRPA;SIRPB1;SIRPG SOCS2 SOCS3 SOCS1 CBL ERBB2 EIF4EBP1 FLNA FYN RELA PTPN1 PTPN11 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260211%WP4504%HOMO SAPIENS Cysteine and methionine catabolism GCLC CTH AHCY SQOR CSAD SUOX BHMT ETHE1 GOT1-1 CDO1 MTR-1 MAT1A CBS;CBSL MPST GSS COMPLEMENT SYSTEM%WIKIPATHWAYS_20260211%WP2806%HOMO SAPIENS Complement system PRKCA ALB CALR-1 CSNK1A1 ITGB3 PROS1 ITGA2B ICAM2 F13A1 C4BPA LAMC1 C8A RPS19 IBSP C1QBP C3AR1 VSIG4 CR2 CD93 ITGA2 FCN2;FCN1 ADIPOQ PLAUR CRP DCN FCER2 CFHR1;CFHR2 MBL2-1 SERPING1 MASP2 MASP1 CFB TLR2 CFD APCS LAMA5 FKBP2 SELPLG C1S C5AR2 C5AR1 CFI WAS APOA1 FPR1 GNAI3 TXN CFP THBS1 GNAI2 CPN1 VTN CLEC4M;CD209-2 C5 GNA15 C6 C7 CD40 FCGR3A;FCGR3B C9 SPP1 ADM CD59 ARRB2 C2 ELANE CD19 CD55 F10 PRKACA-1 F12 CR1L;CR1 LOC110384692;C4A;C4B_2;C4B F11 LAMB1 C3-1 SELE SELP SELL CFH-3 PTX3 KLKB1 ICAM1 FGB FGA FGG PRNP PLG LRP2 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260211%WP4917%HOMO SAPIENS Proximal tubule transport SLC12A4 FXYD2;FXYD6-FXYD2 SLC16A10 ATP6V0E2;ATP6V0E1 SLC22A8 SLC22A7 SLC26A6 SLC2A1 SLC2A2 SLC4A2 SLC4A4 AQP1 CA2 CA4 ATP6V1E1 SLC22A11 ABCC4 ATP6V0B SLC13A3 ATP6V1G1 SLC6A19 SLC36A2 ABCC2 SLC6A18 SLC34A1 SLC5A1-1 ATP1B1 SLC9A3 SLC5A8 SLC7A7 SLC7A8 SLC7A9 ATP6V0C ATP6V0D2 ATP6V1B1 ABCG2 ATP6V1A SLC3A2 SLC22A6 ABCB1 SLC47A1 SLC20A2 SLC22A2 SLC1A1 SLC3A1 ATP1A1 SLC5A2 SLC6A20 SLC5A5 CLTRN ATP6V1H ATP6V0A4 ATP6V1D ATP6V1C1 ATP6V1F ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260211%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway TGFB1 PDGFD F12 ACTA2 RACK1 IL11 COL1A1 JUND IL11RA SMAD2;SMAD3 AGT ACE2 MAS1 CCN2 COL1A2 TGFBR1-1 AGTR1 IL6ST RRAS MAPK1 HIF1A MAP2K6 SMAD4 NOX4 RAF1 SP1 TGFBR2 PTPN11 OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260211%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development RUNX2 NOTCH2 CTNNB1 NOTCH3 NOTCH1 NOTCH4 DMP1 HNF1A KLF4 BMP7 DSPP ALPL SP7 DKK1 SOST OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260211%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies TGFB2 TGFB1 SMAD2;SMAD3 CSNK1A1 WNT7B CTNNB1 NOTCH1 MSTN FNTA CTSK EMD JUNB TMPO TLE1 RUNX2 DICER1 LEMD3 KAT2B MYOD1 MAOB LEF1 TCF7 TNFRSF11B ZMPSTE24 LMNA HES1 MAOA HES5 ACTB-1 TCF7L2 TCF7L1 ICMT CREBBP HMGA2 NAP1L1 TARBP2 BMP2 AGO2 SREBF1 CEBPA CEBPB SPP1 CEBPD GSK3B E2F1 HDAC1 AXIN1 CDKN1A WNT10B CDK4 APC RB1 PPARG QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260211%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis NFKBIA NFE2L2 JUN NFKB1 PTGS2-2 IKBKB CYP2A13;CYP2A6;CYP2A7-1 NOS1 FOS VEGFA KEAP1 ACOX2 MAFG MMP1 MAFK CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias DHCR24 DHCR7 LBR EBP NSDHL CYP51A1 SC5D NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members NFKBIA ZC3HAV1 RELB TBK1 IKBKG NFKB2 BTRC GSK3B SKP1 DDX58 TIPARP TFPI2 PARP16 PARP14 PARP12 RBX1 PARP10 CHUK CLDN6 MAVS MAP3K14 EIF2AK3 ERN1 IKBKB CUL1 CREBBP PARP1 EP300 LUPUS PATHOGENESIS%WIKIPATHWAYS_20260211%WP5559%HOMO SAPIENS Lupus pathogenesis CD40 CD80 TLR4 TNFSF13B IL6 CD40LG CD28 CD274 LOC102723996;ICOSLG TNFRSF13C BCR IL17A TLR9 TLR7 PDCD1 ICOS CD86 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260211%WP3945%HOMO SAPIENS TYROBP causal network in microglia ZFP36L2 ADAP2 HLX NCKAP1L CYTL1 SH2B3 PPP1R18;LOC107987457 IL10RA LHFPL2 CD4 GAPT STAT5A SPP1 C3-1 TGFBR1-1 C1QC ABCC4 CD84 ITGAM FKBP15 NCF2 GPX1 ITGB2 PLEK LOXL3 TCIRG1 PYCARD LYL1 RPS6KA1 CREB3L2 SLC7A7 ITGAX CD37 GAL3ST4 IL13RA1 IL18 LGALS9C;LGALS9;LGALS9B RNASE6 TNFRSF1B RUNX3 SLC1A5 APBB1IP MAF TYROBP BIN2 NPC2 RGS1 ELF4 DPYD HCLS1 SFT2D2 TMEM106A RBM47 IGSF6 KCNE3 NRROS CAPG SAMSN1 EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260211%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance PRKCB NRAS PRKCA MAP2K2;MAP2K1 STAT3 SHC1-1 GAB1 PDGFD KDR PDGFRB PDGFRA PDPK1 GRB2 HGF SOS1 RRAS2 NRG1 FGFR3 NRG2 RRAS MRAS GAS6 EIF4E2 SOS2 MET SHC4 SHC2 SHC3 PIK3R3 PDGFB TGFA BCL2L11 ERBB3 PDGFC EIF4E EGF PLCG2 AXL RPS6KB2 PLCG1 FGFR2 RAF1 NF1 IL6 PTEN ARAF JAK1 BCL2 EGFR GSK3B PIK3CD IL6R PIK3R2 PIK3R1 PIK3CB PDGFA VEGFA IGF1R AKT2 MYC AKT3 MAPK1 AKT1 PIK3CA MAPK3 RPS6 BRAF IGF1 BAX RPS6KB1 KRAS BCL2L1 JAK2 BAD MTOR HRAS CCND1 SRC FOXO3 PRKCG ERBB2 FGF2 EIF4EBP1 COCAINE METABOLISM%WIKIPATHWAYS_20260211%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CES2 CES1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260211%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX ACAA1-1 PTGS2-2 EHHADH-1 PTGFR HPGD PTGDR2 AKR1B1 PLA2G5 PLA2G6 PTGS1 TBXA2R JMJD7-PLA2G4B;PLA2G4B PTGDS PTGR1-1 PTGDR PTGIR PTGIS PPARG PLA2G4A CYP4F3;CYP4F2;CYP4F12;CYP4F11 PTGR2 ACOX2 ACOX1 PRXL2B TBXAS1 ACOX3 PPARD PTGES INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260211%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IL22 IL23R RORC RORA TGFB1 NOD2 IL2RG STAT3 GATA3 HLA-DMA IL18RAP TBX21 IL12A STAT4 IL21R STAT6 SMAD2;SMAD3 IL12RB1 STAT1 IL12RB2 IFNG IL10 IL23A IL4R IFNGR1 IL17F IL13 NFATC1 FOXP3 IL2 IL4 IL5 TLR5 TNF TLR4 JUN NFKB1 TLR2 IL6 IL18 MAF IL1A IL21 IL3 SIGNALING%WIKIPATHWAYS_20260211%WP286%HOMO SAPIENS IL3 signaling TGFB1 PTPN6 MAP2K2;MAP2K1 STAT3 SHC1-1 MAPK8 GRB2 SOS1 STAT5A STAT5B RAF1 JUN JAK1 CD86 YWHAB BCL2 PRKACA-1 YWHAQ PIK3CD PIK3R2 PIK3R1 FOS CXCL8 MAPK1 IL5RA AKT1 CRKL MAPK3 ENPP3 CCR3 SYK HCK IL3RA RAPGEF1 CSF2RB INPP5D LYN IL3 CD69 BCL2L1 JAK2 BAD HRAS GAB2 VAV1 SRC CBL FYN PTPN11 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260211%WP408%HOMO SAPIENS Oxidative stress response GCLC SOD2 SOD3 NFE2L2 MAPK10 FOS GPX1 MAPK14 JUNB SOD1 CYBB CAT NOX4 NFIX NOX1 MGST1 TXN2 NFKB1 XDH NQO1 UGT1A1;UGT1A6 TXNRD2 SP1 GSTT2B;GSTT2 CYP1A1 MAOA NOX3 NOX5 HMOX1 GSR TXNRD1 FELBAMATE METABOLISM%WIKIPATHWAYS_20260211%WP2816%HOMO SAPIENS Felbamate metabolism CYP2E1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260211%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids ABCC2 ABCB1 SLC51B ABCC3 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 FABP6 SLC10A1 SLC10A2 ABCB11 ABCC4 SLC51A TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260211%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners SKI ING2 LATS2 SIN3A SKIL TEAD1 NF1 TEAD2 TEAD3 HDAC1 TEAD4 PRMT5 HDAC3 SATB2 MERTK STK3 LATS1 MECP2 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260211%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism MCCC1 HSD17B10 ACAD8 BCAT1 BCKDHA MCCC2 DLD ECHS1 BCKDHB IVD HIBADH ACSF3 ACAT1 ALDH6A1 ACADSB PCCA PCCB DBT MMUT AUH MLYCD HMGCLL1 BCAT2 HIBCH FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260211%WP5428%HOMO SAPIENS FGFR4 p G388R signaling STAT3 FGFR4 IL10 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260211%WP3927%HOMO SAPIENS BMP signaling in eyelid development FGF10 SMAD4 FGFR2 JUN EGFR MAPK9 NOTCH1 FOXC2 SMAD1 FOXC1 MAP3K1 INHBB MAPK3 SMAD5 TGFA BMP4 SHH DKK2 SFRP1 PITX2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260211%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling DDIT3 BCL2 MAP2K2;MAP2K1 MAPK10 MAPK9 MAPK8 FOS MAPK1 MAP3K1 MAPK3 MAP2K6 EIF4E MAPK14 RPS6KA3 JUNB MAP3K9 MAP3K4 MAP2K3 MAP2K4 RPS6KA1 JUN MAPK12 RAF1 ATF2 RPS6KA2 MAPK13 BST2 MAPK11 MAP3K10 MAP3K11 IFITM3;IFITM2;IFITM1 MAP2K7 FOXA2 PATHWAY%WIKIPATHWAYS_20260211%WP5066%HOMO SAPIENS FOXA2 pathway SREBF1 ABCC2 FOXA1 MTTP GSTM1;GSTM2-1 ACACA GSTA3;GSTA1 FASN ABCC3 GSTA3;GSTA5;GSTA1;GSTA2 INS;INS-IGF2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 PPARGC1B SLC27A5 IRS1 FOXA2 IRS2 APOB ABCC4 FOXO1-1 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260211%WP229%HOMO SAPIENS Irinotecan pathway ABCC2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 BCHE ABCC1 CES2 CES1 UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCG2 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260211%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis WNT3 WNT5A WNT3A FZD1 CCND1 LRP6 NEUROD1 FZD3 PROX1 NEUROG2 WNT7A NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260211%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis FADD TRADD PARP1 PLA2G4A CASP8 TNF TNFRSF1A RIPK3 MAPK8 FTL-1 RIPK1 TICAM1 CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260211%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia IL1R1 FBXO32 NFKBIA CEBPB ACVR2A REL RELB STAT3 IKBKG NFKB2 IL6R SMAD2;SMAD3 RPTOR CHUK IGF1R MLST8 IL1B TNF MAP1LC3A AKT1 TNFRSF1A MSTN IGF1 SMAD4 AKT1S1 NFKB1 IKBKB MAPK11 MTOR IL6 IL1A FOXO3 JAK1 PDK1 RELA EP300 TRIM63 TNFRSF12A LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260211%WP4299%HOMO SAPIENS Lamin A processing pathway ICMT ZMPSTE24 LMNA BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260211%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment STAT3 GAB1 FRS2 MAPK8 GRB2 SOS1 BMP7 CASP8 MAP3K1 BDNF MAP2K4 LEF1 MAPK11 TCF7 TCF7L2 TCF7L1 ARHGAP35 ARHGDIA CFL2 IKBKG STMN1 CFL1 PRKCI TIAM2 TIAM1 PARD3 MAPKAPK2 RTN4R IQGAP3 RAP1B FADD NPTX2 MAP2K5 NGFR EEF2 DIAPH1 MYC TP73 DOCK7 WASL MAPK1 AKT1 RND3 EEF2K MAPK3 RHOA TRAF6 CRK ROCK1 ROCK2 PARD6B PARD6A MAPK7 BAX MKNK1 RPS6KB1 SH2B2 MAP3K3 KRAS PIK3CG LINGO1 NTRK2 SORT1 IKBKB KIDINS220 LIMK1 HRAS PRKCG EIF4EBP1 PRKCH PTPN11 PRKCB CYCS-1 NFKBIA PRKCE PRKCD NRAS PRKCA MAP2K2;MAP2K1 SHC1-1 PDPK1 SMPD1 CTNNB1 IRS1 IRS2 PRKCZ BCL2L11 MAP3K5 EIF4E RPS6KB2 PLCG1 RAF1 JUN TRADD RAC1 YWHAE MAP2K7 YWHAB BCL2 GSK3B YWHAQ PAK1 PIK3CD PIK3CB YWHAG CASP9 YWHAH YWHAZ CHUK APAF1 CREB1 PIK3CA RAPGEF1 BAD MTOR CDC42 TP53 FOXO3 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases MAPK10 MAPK9 MAPK8 FGFR3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 FGFR4 PIK3R3 SMAD5 BMP4 FGF10 MAPK12 MYOD1 MAPK13 MAPK11 BMP2 FZD10 PRKCI PIK3R4 PIK3R2 PIK3R1 FZD1 WNT10B WNT10A FZD3 MAPK1 FZD2 FZD5 MAPK3 FZD7 FZD6 FZD9 FZD8 MAPK7 PIK3CG IHH RBPJ FGF1 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 PTCH1 FGF9 SOX9 HES6 PRKDC PIK3R6 PIK3R5 PRKCG JAG2 JAG1 FZD4 PRKCH SMAD9 SMO FGF18 BMPR1B PRKCB FGFR1 PIK3C2G PRKCE PIK3C2A PRKCD GLI3 GLI2 PRKCA PIK3C2B HEY1 HEY2 WNT9B WNT9A WNT8A WNT8B DLL1 DLL3 WNT7B PRKCQ DLL4 WNT7A PRKD1 HES3 MAPK6 HES2 MAPK4 CTNNB1 PRKCZ SMAD1 WNT5B WNT5A SMAD4 RUNX2 FGFR2 BMPR1A BMPR2 WNT6 WNT1 WNT2 WNT3 WNT4 WNT3A WNT2B PIK3CD PIK3CB STAT1 WNT16 PIK3CA PIK3C3 MAPK14 LRP5 LRP6 WNT11 PPARG FGF2 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260211%WP5088%HOMO SAPIENS Prostaglandin signaling TGFB1 IL12A IFNG VEGFA CD28 IL17F PTGER4 CXCL9 CSF1 PTGER2 IL1B AREG NLRP3 IL17A CXCL8 TNF CXCL2;CXCL3;CXCL1-1 MMP9 CXCL10 IRF7 KLRD1 CCL3L1;CCL3L3;CCL3;CCL18 CCR2 CASP1 CCL13;CCL2 PYCARD PIK3CG NFKB1 IL6 AHR IL1A PTGES DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260211%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein AGTR1 ACE2 ACE AGTR2 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260211%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS MYT1 GLI2 IL1B TNF CXCL2;CXCL3;CXCL1-1 PDGFB BMP4 SHH IGF1 CNTF CNP ASCL1 MBP SOX8 SOX6 SOX5 NKX2-2 NKX2-6 MOG OMG LIF OLIG1 OLIG2 SOX10 MAG PLP1 SOX9 BMP2 FGF2 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome CHRNA7;CHRFAM7A KAT2B CCL5 MTMR10 KLF13 CREBBP OTUD7A GPR75 TRPM1 FANCD2 GRM6 SERPINH1 FAN1 FYN ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment NFKBIA CHUK IKBKG TNF NFKB1 IKBKB MUC1 IL6 RELA MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CYCS-1 CDC25A BID MDM2-2 FAS CCND2 ABL1 CASP8 GADD45A SFN CCNE1 ATM ATR BRCA1 FANCD2 CDKN1B HUS1B BBC3 PIDD1 CCND3 SESN1 TLK2 TLK1 NBN RFC1 SMC1A CDK5 CDC25C DDB2 CCNE2 RRM2B E2F1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CCNB3 CCNB2 CASP9 CCNB1 PMAIP1 PML ATRIP CASP3 GADD45B RPA2 RAD50 APAF1 GADD45G RAD52 RAD51 CREB1 CCNG1 CDKN1A CDK1 MYC RAD17 RAD1 RAD9A BAX CDK4 CDK2 RB1 MRE11 CDK6 TP53 CCND1 CHEK2 PRKDC CHEK1 PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260211%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence NRAS GNAS-1 PTGS2-2 SIRT1 PTGER4 CDKN1A PTGER2 PTGER1 PTGER3 ALOX12 LTC4S GNAI1 CYSLTR1 ALOX5 LTA4H ALOX15B ALOX5AP ADCY3 KRAS MAPK11 ALOX15 RB1 HRAS PTGS1 GNAQ PTGDS TP53 PTGIS PLA2G4A PRXL2B TBXAS1 IGFBP5 PTGES CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260211%WP3594%HOMO SAPIENS Circadian rhythm genes SIN3A MAPK10 MAPK9 MAPK8 DDC MTTP CUL1 PROX1 TH NGFR ROCK2 CDK4 PRKDC PRKCG AHCY ATF5 ATF4 ADIPOQ JUN IL6 TPH2 TPH1 GNAQ CHRM1 HDAC1 CREB1 CRH PRF1 HNRNPU CCAR2 ADCY1 SLC9A3 HTR7 PROK2 PROK1 UTS2R CPT1A METTL3 SOX14 HNF1B CLDN4 UBA52 CLOCK DHX9 MAGED1 NKX2-1 OGT-1 PPARGC1A EGR1 EGR3 HOMER1 NR1D2 NR1D1 NR2F6 SETX STAR NMS ID4 HNRNPD ID3 FBXL3 ADA ID2-1 TOP2A SUV39H2 SUV39H1 BHLHE41 NCOA2 JUND SLC6A4 KCND2 SFTPC PAX4 MC3R NCOR1 KCNMA1 AVP SIRT1 PPARA PHLPP1 CIPC TYMS ARNTL2 ARNTL NPS PROKR1 PROKR2 NFIL3 SIK1;SIK1B RPS27A UBB;UBC ARNT2 CAVIN3 NR1H3 PPP1CA PER2 PER1 MYBBP1A GHRH GHRL AGRP LGR4 CRTC1 NPY2R UBE3A RORB PPP1CB PPP1CC NAGLU ADORA1 CHRNB2 FBXW11 KCNH7 USP2 DYRK1A HDAC2 CARTPT MTNR1A MTNR1B PSPC1 TIMELESS DDX5 MAGEL2 KMT2A EP300 CREM EZH2 TNFRSF11A SREBF1 NPAS2 RAI1 AANAT DRD1 RELB DRD2 DRD3 DRD4 BTRC ZFHX3 SKP1 OPN4 OPN3 NONO GFPT1 BTBD9 PRKAA2 BHLHE40 RBM4;RBM4B KDM5A HEBP1 DBP SIX3 PRKG2 SFPQ-1 KLF10 ARNT ADORA2A THRAP3 CRY2 CRY1 TOP1 NLGN1 PRKAA1 CRX OPRL1 CIART ATOH7 MTA1 GNA11 NOCT NRIP1 NTRK1 NTRK3 HCRTR2 HS3ST2 HCRTR1 LEP KLF9 AHR CSNK1D FAS PTGDS PTEN RORC RORA TPTEP2-CSNK1E;CSNK1E GSK3B PML CST3 NOS2 SERPINE1 TP53 NAMPT PPARG PRMT5 F7 HDAC3 GPCRS OTHER%WIKIPATHWAYS_20260211%WP117%HOMO SAPIENS GPCRs other OR2B6;OR2B2-1 GNRHR CCR5 GPR135 ADGRV1 ALG6 OR8G1;OR8G5 OR1F1 F2R OR2H1-1 TAAR5 OR1J2 TAAR2 SSTR2 OR1N1 GPR162 LTB4R2 CCKBR FSHR ADGRF5 VN1R1 OR1E1;OR1E2 OR6C3 OR10A5 OR3A1 GPR88 PROKR2 OR2A7;LOC107987545;OR2A4 GPR84 ADRB2 MCHR2 CCR2 GHRHR ADGRG1 CXCR1 CNR1 CXCR3 CXCR2 HRH4 S1PR1 OR6C2;OR6C68 OR5AC2-2 PTGFR NTSR1 P2RY13 GPR17 P2RY11 GPR83 HTR1F OR2F1-2 GPR55 C5AR2 ADGRD1 GPR143 GPR183 ACKR1 OR2A5 LGR6 ADGRL2 GPR18 ADGRL3 DRD3 DRD4 ADORA2A HTR7 UTS2R RXFP1 CHRM2 CHRM3 OR2M4 GPR61 ADRA1D HTR2A GPR62 CELSR1 GRPR CELSR2 OR7E24-1 CELSR3 GRM1 RXFP3 EDNRA GPR176 GPR132 ADGRE3 SMO ADORA3 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5049%HOMO SAPIENS Glycolysis in senescence TP53 PKM LDHA G6PD PGK1 ALDOC ENO1 HK1 RB1 PRKAA1 GAPDH-1 RETINOL METABOLISM%WIKIPATHWAYS_20260211%WP5188%HOMO SAPIENS Retinol metabolism RDH12 DHRS9 AWAT2 PNPLA4 AOX1 LRAT ALDH1A1 RDH13 BCO1 CYP2A13;CYP2A6;CYP2A7-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH1C;ADH1B;ADH1A CYP1A1 RPE65 DHRS4 SDR16C5 CYP2W1 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260211%WP1403%HOMO SAPIENS AMP activated protein kinase signaling PIK3R3 ADIPOQ RPS6KB2 ACACA FASN PPARGC1B SREBF1 PRKAG1 PRKAG2 PIK3CD SLC2A4 PIK3R2 ADRA1B PIK3R1 PIK3CB ELAVL1 PRKAA2 CRTC2 ADRA1A CCNB1 PRKAG3 RPTOR GYS2 GYS1 LIPE HNF4A INS;INS-IGF2 LEPR CCNA2-1 EEF2 CDKN1A AKT2 PRKAB2 STRADA STRADB CPT1C AKT1 PRKAB1 EEF2K CPT1B PIK3CA CCNA1 PIK3C3 INSR PFKFB3 PRKAA1 CAB39 ADIPOR1 ACACB ADIPOR2 CAMKK1 CAMKK2 RPS6KB1 SLC2A4RG PIK3CG CPT1A PRKACB-1 MTOR LEP HMGCR TP53 STK11 PLCB1 EIF4EBP1 TSC2 TSC1 IL2 SIGNALING%WIKIPATHWAYS_20260211%WP49%HOMO SAPIENS IL2 signaling IL2RG MAP2K2;MAP2K1 STAT3 SHC1-1 PIK3R1 STAT1 GRB2 SOS1 IL2 MAPK1 AKT1 CRKL MAPK3 RPS6 SYK STAT5A STAT5B RPS6KB1 RPS6KB2 PTK2B JAK3 NMI RAF1 LCK IL2RA IL2RB CISH HRAS GAB2 FOXO3 SOCS3 JAK1 MAPT CBL FYN PTPN11 CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies EGFR CD4 GZMH;GZMB-1 ITGA4 IL15 DHODH IFNG F2RL1 ITGB7 TGM2 IL2 TNF IL21 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260211%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF2S1 EIF2S2 EIF2S3;EIF2S3B EIF1 EIF3C;EIF3CL EIF5 EIF1AY;EIF1AX EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP5094%HOMO SAPIENS Orexin receptor pathway NPFFR1 PRKCB DAGLA SGK1-1 PRKCE FSHB PRKCD RRAGC PRKCA LHB MAP2K2;MAP2K1 STAT3 PDHB GNAS-1 PLD1 NPY NPVF MAPK9 VHL MAPK8 CGA HCRT DYNLT1 OPRK1 PDPK1 GCG PRKD1 CCK POMC IL9 GNRH1 GRIA1 TNF CXCL2;CXCL3;CXCL1-1 PRKCZ SMAD1 BMP7 SMAD5 HIF1A ADIPOQ RUNX2 GHRL IL6 BMPR1A GNAQ PDK1 ARRB1 ARRB2 NFE2L2 SLC2A4 PIK3R2 PIK3R1 CASP9 TH IL10 CASP3 SLC2A1 CREB1 IL1B EIF4B IL4 SLC1A2 CXCL8 MAPK1 MAPK3 RPS6 PRKAA1 GNAI1 FOXO1-1 MAPK14 CAMKK2 MAPK7 GNA11 RPS6KB1 NOX4 RPS6KA1 HCRTR2 HCRTR1 MTOR LEP EIF4EBP1 PLCD1 STAR PTPN11 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260211%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHA SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHB CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260211%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function PRKCB PRKCE PRKCD SNAP25 PRKCA PRKCI C3-1 PRKCQ SLC2A1 PRKCZ MMP9 MMP21 MMP20 MMP25 MMP24 MMP27 SCN9A MMP28 TKTL1 MMP7 TRPA1 BDNF MMP2 MMP3 SORD TRPV1 NOS2 MMP8 MMP10 MMP12 MMP11 MMP14 SCN10A MMP13 MMP16 PRKD3 AGER MMP15 SCN8A MMP23B MMP17 MMP19 PRKCG MMP1 PRKCH CYTOSINE METHYLATION%WIKIPATHWAYS_20260211%WP3585%HOMO SAPIENS Cytosine methylation DNMT1 MBD3 TDG IDH2 TET1 TET2 MECP2 IDH1 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260211%WP4918%HOMO SAPIENS Cellular proteostasis PFDN4-1 VBP1 PFDN1 PFDN2 PFDN5 PFDN6 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260211%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway AMD1 APIP ODC1 MRI1 MAT2B IL4I1 MSRA AHCY MTAP MAT2A SMS ADI1 CHDH BHMT MSRB2 MSRB3 ENOPH1 MTR-1 TAT SRM TXN MAT1A HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260211%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway IRF6 TP63 TGFB3 RHOA TFAP2A ARHGAP29 ARHGEF2 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260211%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling FN1 COL1A1 GRB2 SOS1 FGFR3 FGFR4 FGF10 FOXA1 ACACA GHR IL6R CRTC2 FLT1 PDGFA TCL1B IGF1R TCL1A NGFR INS;INS-IGF2 PPP2R1B CREB3L3 AKT2 CDKN1A PPP2R1A IFNB1-4 CREB3L4 AKT3 CREB3L1 MAPK1 AKT1 CDC37 DDIT4 MAPK3 PPP2R2A;PPP2R2D INSR EPHA2 EPAS1 LPAR2 FOXO1-1 LPAR3 IGF1 LPAR4 GNG10 PGF LPAR5 LPAR6 CAB39L ITGB1 PPP2CB;PPP2CA PRL KRAS HIF3A PIK3CG ATF2 RAB8A OSMR JAK2 COL2A1 KIT PHLPP2 TNXB COL11A1 FGF1 COL11A2 FGF3 PRLR RELN FGF4 VEGFB OSM FGF6 VEGFC FGF7 VEGFD FGF8 RAB11B FGF9 COL3A1 KITLG CSF3 CSF3R PIK3R5 EPO TNN TNR EIF4EBP1 IFNAR2 RAB2A COL4A2 FGF18 COL4A1 PTK2 EIF4E1B FGFR1 COL4A4 COL4A6 PIK3C2A IFNAR1 PFKFB2 PFKFB1 PIK3C2B CSF1R PFKFB4 EFNA5 EFNA4 HSP90B1 CHAD FGF20 FGF22 ITGB3 FGF21 ITGA2B FGF17 EFNA1 FGF16 ATF4 EFNA3 FGF14 LAMC1 EFNA2 LPAR1 COL5A1 IBSP ITGA10 COL5A3 FGF19 ITGA11 COL5A2 IL7R FGF13 ITGA2 FGF12 FGF11 HSP90AB1 ITGB5 LAMC3 TNC ITGB4 FLT4 LAMC2 ITGAE ITGAL PPP2R5E ITGB8 GNG13 ITGAV ITGB6 HSP90AA1 LAMA5 VWF GNB2 ITGA3 PPP2R5B CHRM1 PPP2R5A PPP2R5D PPP2R5C NGF GNB1 TBC1D1 GNB4 ITGAD GNB3 COL6A2 ITGA8 ITGA7 THBS1 ITGA6 ITGA5 VTN ITGA9 CDKN1B CREB5 LAMA2 LAMA1 LAMA4 LAMA3 THBS2 THBS4 SPP1 THBS3 PPP2R3C ANGPT4 ANGPT2 GNGT1 LAMB3 ANGPT1 LAMB2 PPP2R3A NOS1 LAMB1 EPOR RAB10 PIK3IP1 PPP2R2C RAB14 PPP2R2B TEK SLC2A1 CREB3 SLC2A2 CREB1 ATF6B GNG2 GNG5 GNG4 GNG8 NOS3 PPARGC1A PDGFD COL1A2 PHLPP1 HIF1A SREBF1 ULK1 IKBKG PIK3R4 PIK3R2 PIK3R1 PRKAA2 RPTOR MLST8 EIF4B RPS6 ITGAM PRKAA1 ITGB2 RPS6KB1 RHEB AKT1S1 CREB3L2 ITGAX IKBKB HRAS CHRM2 STK11 TSC2 TSC1 NRAS MAP2K2;MAP2K1 F2R KDR PDGFRB PDGFRA MDM2-2 PDPK1 HGF CSF1 IRS1 EIF4E2 IRS4 IRS2 MET PDGFB PDGFC EIF4E EGF RPS6KB2 FGFR2 RAF1 PTEN JAK1 IL2RG EGFR GSK3B PIK3CD SLC2A4 PIK3CB ELAVL1 CASP9 GYS2 VEGFA IL4R GYS1 LIPE IL2 STRADA PIK3CA PFKFB3 CAB39 IL3RA JAK3 NOS2 IL2RA BAD IL2RB ITGA4 MTOR ITGB7 FOXO3 FGF2 COMP INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260211%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases CEBPB BDNF PPP2CB;PPP2CA NTRK2 MAOB STAT1 SRPK2 BACE1 SET-1 APP TARDBP LGMN AKT2 SNCA AKT3 AKT1 MAPT MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260211%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer MAP2K2;MAP2K1 KRAS SHC1-1 JUN RAF1 FOS SOS1 ALK KSR1 MYC SOS2 GAREM2 MAPK3 ELK1 BRAF INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260211%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR NELFB NFKBIA NELFCD NELFA NELFE HDAC1 PPP3R1 NFATC1 HDAC4 HDAC5 CCNT1 HDAC8 HDAC9 HDAC7 SUPT4H1-1 HEXIM1 NFATC3 NFATC2 SUPT5H NFATC4 CDK9 NFKB1 PPP3CA PPP3CB PPP3CC SP1 CREBBP HDAC2 HDAC3 RELA EP300 TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260211%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production AFMID IDO1 NMNAT3 NMNAT2 NADSYN1 NMNAT1 NMRK2 NMRK1 NAPRT TDO2 NAMPT AADAT HAAO QPRT KMO KYNU INSULIN SIGNALING%WIKIPATHWAYS_20260211%WP481%HOMO SAPIENS Insulin signaling RAB4A EHD1 SGK1-1 ARHGAP33 EHD2 MAP3K12 SNAP25 ARF1 SNAP23 PTPRF GAB1 FLOT1 MAPK10 FLOT2 CAP1 MAPK9 MAP4K1 MAPK8 MAP4K2 MINK1 GRB2 TBC1D4 RHOJ SOS1 RHOQ GRB14-1 ARF6 CYTH3 STX4 SGK3;C8orf44-SGK3 SRF MAP4K5 MAP4K3 MAP4K4 MAP3K2 MAP3K1 PIK3R3 REG1B;REG1A ELK1 SORBS1 VAMP2 PFKL MYO1C PFKM STXBP1 RPS6KA3 MAP3K9 MAP3K4 MAP2K3 MAP2K4 MAPK12 MAPK13 MAPK11 MAP3K10 MAP3K11 PRKCI PIK3R4 PIK3R2 PIK3R1 PRKAA2 IGF1R MAP2K5 MAP3K14 AKT2 XBP1 MAPK1 AKT1 MAPK3 INSR CRK PRKAA1 FOXO1-1 MAPK7 RPS6KB1 RHEB SH2B2 MAP3K3 RPS6KA1 PIK3CG RPS6KA2 IKBKB HRAS SOCS3 SOCS1 EIF4EBP1 TSC2 PRKCH TSC1 PTPN1 PTPN11 PRKCB PIK3C2G PIK3C2A PRKCD PRKCA MAP2K2;MAP2K1 SHC1-1 PRKCQ PDPK1 MAPK6 MAPK4 IRS1 IRS4 SOS2 IRS2 PRKCZ SHC2 SHC3 KIF5B MAP3K5 EIF4E RPS6KB2 RAF1 JUN MAP3K13 GSK3A PTEN RAC1 MAP2K7 GSK3B PIK3CD SLC2A4 PIK3CB GYS2 FOS GYS1 LIPE SLC2A1 PIK3CA PIK3C3 MAP2K6 RAPGEF1 MAPK14 MTOR INPPL1 CBLC CBLB RPS6KA4 RPS6KA6 RPS6KA5 GRB10 ENPP1 MAP3K8 MAP3K6 GYG1 FOXO3 EGR1 MAP3K7 INPP4A TRIB3 STXBP3 CBL STXBP4 RRAD STXBP2 PPP1R3A KIF3A BDNF TRKB SIGNALING%WIKIPATHWAYS_20260211%WP3676%HOMO SAPIENS BDNF TrkB signaling NRAS MAP2K2;MAP2K1 SHC1-1 GAB1 GRB2 GRIN1 SOS1 CREB1 MAPK1 AKT1 EEF2K BRAF TRPC6 TRPC3 ARC DLG4 MKNK1 BDNF RPS6KB1 PLCG1 RHEB ADCY1 KRAS PIK3CG RPS6KA1 NTRK2 MTOR HRAS GAB2 HOMER1 EIF4EBP1 TSC2 TSC1 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades CLTC F2R PROS1 C3AR1 CR2 PLAUR SERPINA1 CLU SERPING1 SERPINA5 MASP2 THBD MASP1 C8G CFB PLAU BDKRB1 CFD SERPINF2 F3 VWF F5 F8 F9 C1S CPB2 C1R C5AR1 APOA2 SERPINC1 CFI KNG1 LMAN1 SERPIND1 PROC F13B C6 C1QB C7 C9 TFPI C2 CD55 F10 F12 CR1L;CR1 LOC110384692;C4A;C4B_2;C4B C3-1 CFH-3 KLKB1 C1QC SERPINE1 PLAT FGB F2 F7 PLG ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2881%HOMO SAPIENS Estrogen receptor pathway STAT3 JUN SP1 CYP1A1 PPARA PDK4 NR0B2 PCK1 GPAM ACOX1 CYP1A2 CYP1B1 ESR1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260211%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV NRXN2 RPH3A SYNGAP1 DLGAP1 NLGN4X;NLGN4Y NRXN1;NRXN3;NRXN2 TJP1 DLG2 SHANK1 YWHAG GRIN2A GRIN1 CAMK2B MAPK1 MAPK3 CAMK2D NLGN1 STX1A CAMK2A GRIN2C ARC GRIN2B GRIN2D DLG1 CAMK2G HOMER1 GRM1 NLGN3 CYFIP1 RYR2 NLGN2 FMR1 NRXN3 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260211%WP5146%HOMO SAPIENS Lung pathology of COVID 19 CCL13;CCL2 TBK1 NFKB1 CSF2 DDX58 CGAS IFIH1 IL6 IL18 CXCL11 STING1 IRF3 TLR8 TLR3 MAVS CXCL9 IL1B TNF TLR7 CXCL10 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260211%WP1604%HOMO SAPIENS Codeine and morphine metabolism ABCC2 ABCB1 CYP2D6;LOC107987479;LOC107987478-1 ABCC3 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IL17 SIGNALING%WIKIPATHWAYS_20260211%WP2112%HOMO SAPIENS IL17 signaling IL25 CEBPB CEBPD NFKBIB STAT3 IKBKG GSK3B IL17F IL17D IL17C TRAF3IP2 MAP3K14 IL17RE IL17B IL17RD IL17RC IL17RB IL17A MAPK1 IL17RA AKT1 TRAF3 MAPK3 PIK3CA TRAF6 NFKB1 IKBKB JAK2 SP1 MAP3K7 JAK1 RELA ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP697%HOMO SAPIENS Estrogen metabolism NQO1 UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GSTM1;GSTM2-1 CYP1A1 GSTA3;GSTA1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP1A2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP1B1 COMT ARSD-1 STS ARSL MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260211%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes TUBA1A RARS1 MARS2 UBE2J1 TDG IDH1 MAT2A P4HA2 TCL1A CDKN1A KRAS KIT PPIB COL4A2 LAMC1 C1QBP ITGA2 LAMC2 PPP2R5C GNAI2 ATP2A2 YWHAQ HDAC4 ABCG2 MAP3K8 ATP6V1C1 ATP6V1F SLC12A4 ATP6V0E2;ATP6V0E1 SNAP23 PTPRF CAP1 NOTCH2 NOTCH1 NF2 GPAM CYP1B1 CYP51A1 PPP3R1 SERPINE2 EHMT2 EHMT1 CLDN1 DCAF7 RRP8 RAVER2 MYB CDK5RAP1 ANKFY1 CDK5RAP3 TMEM41B-1 PPP3CA HOXA5 MBNL1 CACNA2D1 FNDC3B FNDC3A SCAMP1 GTPBP3 BACE1 MTHFD2 WDR82 FAR1 OTULINL ABCF2-H2BE1;ABCF2 HACD3 MRPL20 TERT RDH10 GRPEL2 CEP72 VTI1B GSTM4 CAPG PHC2 HNRNPM MOV10 PPP5C TNFSF9 SFXN1 STRN FERMT2 HOXD8 CDKN1C ASH2L MRC2 PANX1 CHAF1A TMEM43 CSRP1 SH3BGRL3 ANXA2 ELOVL5 ELMOD2 CTNNB1 SLC7A6 ZEB1 PXDN IRS1 PTRH1 PAFAH1B2 MET VAMP3 PPP1R7 USP1 TAF9B SRSF10 CDKN2A TRMT1 TTC9C HIPK3 EIF4E ARCN1 WNT5A WDR11 AXL NFIA SNX15 NUCB1 PPIF PKN2 LAMTOR3 LAMTOR5 LY6K PLXND1 LPL TUSC2 LTN1 MSI2 ARF4-1 LCLAT1 IPO4 FADS2 ABHD10 RTN4 ABHD11 POGLUT3 KPNA3 FADS1 MYLIP TPM4 TPM3 TPM2 TPM1 STX7 RAB30 DMTF1 RAB34 ANAPC1 SRSF9 RAB5C CBFB UAP1 CORO1C SLC9A3R2 THEM4 RAB6A SLC38A2 SAC3D1 MCL1 MPDU1 CD164 SLC4A10 NCL-1 CXCL12 BCL6 CNOT9 SLC25A1 ADPGK SYNE2 SYNE1 PTBP1 DNMT3B ACP2 SNAP29 PGM1 ATRX SIGMAR1 RAD23B PTBP2 NT5C3A SLC25A13 MTPN SEC23A LUZP1 NUFIP2 UNC93B1 UHRF1 PLAG1 TXN2 HSD17B12 DNAJB1 POLR2C RAB23 TP53INP1 IGF2BP1 CDK6 SH3BP4 LRRC8A E2F3 ZNF622 SLC25A22 SLC25A24 SLC12A2 NPR3-1 SEC24A MYO10 TM6SF1 MYO1E PSAT1 FGF2 PDCD4 SLC25A32 CUL4B BET1 CPNE8 VEZT SRPRB-1 NELFCD PWP1 ANPEP DHX57 CHORDC1 ARFIP2 ARFIP1 CIAO2A SEC62 CCN1 ARL10 IFRD1 BCKDHB PISD DHX40 CARHSP1 METTL7A-1 KCNQ1 FXR2 COMMD9 KCNN4 ATP6V0A1 SNX6 HARS1 RAB27B BRI3BP POLA2 NCEH1 PDE3A ANP32B RCOR1 NRP1 TRAM1 GFM1 PTPRJ BDNF MAGT1 MEOX2 COIL TMED3 MAPK12 DHX15 GNL3L-1 GNPNAT1 TMED7 CTSC MRPS24 RHOG AP3B1 PRPF40A RHOB GAK CDCP1 CSDE1 FRG1 POM121;POM121C AGO3;AGO1 PTMA BRPF3-1 PRIM1 MRPS33 SSNA1 AMIGO2 AKAP8 NAPG PTPA PURA NT5E PGRMC1 ATAD3A;ATAD3B SHOC2 MPZL1 ARHGDIA MTX1 SPRYD4 AP3D1 PRKCI YIF1B SPCS3 TPPP3 NEDD4 TRIP13 ACAA2 IQGAP3 C1orf56 GEMIN2 CPOX ARID4B NARS1 ARID2 UBE4A CDKAL1 GOLGA7-1 DOCK7 MYCN GPD2 WDFY1 MATR3 GEMIN7 ATAT1 RAI14 TMED10 SLC1A4 SYPL1 SDCBP GAS2L1 PEDS1-UBE2V1;PEDS1 MAPK7 VCAM1 TBCA IGF2R TRPV6 UBE2S CHMP2A PICALM DOCK5 TNFAIP2 ADAR CHD1 LMNB2 TMEM109 SCYL1 UTP15 TMED2-1 HSDL1 RBM19 ARID1A RCN2 RFT1 RBMS1 PNP-1 NXN AURKB GNA13 CAND1 POLD2 PDLIM5 CDIPT PDLIM7 GALNT7 GALNT1 POLE4 SLC4A7 FMNL2 NAA15 SPTLC1 G6PD CDKN1B BCL2 SMC1A TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BACH1 SLC38A1 CLOCK HMOX1 TXNRD1 AP2A1 TYMS FBXW11 DNMT3A DDX5 EZH2 CEBPB GFPT1 CALCOCO2 VPS39 ATG3 ATG9A TMEM59 PKM RHEB RB1 CCND1 CSNK1D SMAD1 PLK1 NCOA3 TGFBR2 EGFR E2F1 GYS1 ADIPOR2 MAPK14 MTRR SUCLG2 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260211%WP5485%HOMO SAPIENS Post COVID neuroinflammation CCL11 TLR4 GFAP TMPRSS2 IL12A FURIN HMGB1-1 IL6 IL18 ACE2 IFNG IL10 TLR8 TLR3 IL1A IL2 IL4 IL1B CXCL8 TNF MAPK1 TLR7 IL7 SIGNALING%WIKIPATHWAYS_20260211%WP205%HOMO SAPIENS IL7 signaling STAT5A STAT5B PTK2B STAT3 IL2RG MAP2K2;MAP2K1 JAK3 GSK3B BAD PIK3R2 PIK3R1 IL7 STAT1 MAPK1 AKT1 JAK1 MAPK3 IL7R FYN KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260211%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KLKB1 KNG1 SERPING1 F12 BDKRB1 CPN1 BDKRB2 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260211%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GIP GCG OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260211%WP5574%HOMO SAPIENS Oligodendrocyte development MYT1 EGR2 GLI2 ID2-1 PRKCA PDGFRA MYRF CHD8 CHD7 PTN ZNF24 DUSP15 SOX2 PTPRZ1 NKX6-1 WNT10A ZNF488 LGI1 SMAD1 OPALIN SOX11 ZBTB33 BMP4 ZEB2 SHH BMP1 TMEM98 CNTN1 CSPG4 NFATC2 ASCL1 MBP NFIA SOX8 SOX6 SOX5 NKX2-2 NKX2-6 OLIG1 OLIG2 SOX10 RELN HES5 MAG TCF7L2 SOX9 FGF2 ID4 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260211%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260211%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging SIRT1 IGF1R PTEN AKT1 MTOR FOXO1-1 NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260211%WP4220%HOMO SAPIENS Neurotransmitter disorders SLC6A3 PNMT COMT TPH2 DDC TPH1 TH SLC18A2 MAOA DBH VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260211%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders PDXK PNPO PLPBP ALPG;ALPP;ALPI-1 PIGV ALDH7A1 ALPL DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260211%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development LATS2 H3-3A DLL1 CSNK1A1 SIRT1 NOTCH1 DNM1 LIN54 HIP1 SMARCB1 GMNN GLI1 DNER LIN52 RBL2 PSEN1 HES1 RBL1 HES5 TFDP1 AMPH RAD54L2 APP LIN37 LIN9 DYRK1A RBBP4 E2F5 EIF2B5 REST TFAP4 NEUROG2 SPRY2 CDKN1B GSK3B APH1A CASP9 NCSTN RPTOR DEPTOR CASP3 MLST8 NFATC1 CREB1 CRY2 FOXO1-1 DCAF7 CDK4 AKT1S1 E2F4-1 MTOR PSENEN CDK6 BACE1 TP53 CCND1 MAPT FGF2 TSC2 TSC1 TFDP2 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260211%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway IL1R1 IRAK4 SAFB NFKBIA TOLLIP TAB3 TAB2 NFKBIB MAP2K2;MAP2K1 MYD88 MAPK10 MAPK9 MAPK8 MAPKAPK2 FOS CHUK MAP3K14 MYC MAPK1 MAP3K1 MAPK3 ELK1 IRF7 MAP2K6 TRAF6 EIF4E MAPK14 MKNK1 MBP MAP2K3 MAP3K3 MAP2K4 ATF2 NFKB1 TAB1 IKBKB MAPK11 RPS6KA5 IL1A MAP3K8 MAP3K7 IL1RAP TANK IRAK1 MAP2K7 RELA IRAK2 MKNK2 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260211%WP2363%HOMO SAPIENS Gastric cancer network 2 LBR TOP2A OTUD5 EGFR AHCTF1 DSCC1 CHTF18 MTDH PLAC8 BRIX1 FANCI RFC3 RFC4 UBE2C ATAD2 CACYBP CTNNB1 FAM91A1 RNF144B UBE2T MYC SNURF RAD17 S100A6 CD48 CEBPZ LMNB2 TP53 COL9A1 COL9A3 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260211%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling TGFB1 FN1 GAB1 ACTA2 MAPK9 MAPK8 SMAD2;SMAD3 GRB2 ELK1 SMAD5 SP7 CCL13;CCL2 RPS6KA3 ACACA NR0B2 TJP1 CSF2 PIK3R1 PRKAA2 FLT1 IGF1R FZD1 WNT10B IFNB1-4 MAPK1 AKT1 MAPK3 RPS6 CLDN1 RPS6KB1 ITGB1 RPS6KA1 SRC CSF3 SOCS3 SOCS1 SMAD9 RELA COL4A1 PRKCB PTK2 FGFR1 MAP2K2;MAP2K1 SHC1-1 KDR PDGFRB PDGFRA PDPK1 CTNNB1 ZEB1 ABL1 IBSP TNF SMAD1 CXCL2;CXCL3;CXCL1-1 MMP9 CXCL10 ZEB2 SMAD6 PLCG1 CDH2 CDH1 RAF1 JUN NFKB1 SNAI2 VIM IL6 PTEN GSK3B IL10 FOS VEGFA SLC2A1 HSPB1 IL1B CXCL8 CRKL CXCL5;CXCL6 CLDN5 SLPI MST1R NDRG1 NR4A1 SIX1 MAPK14 HK2 DUSP4 DUSP1 MST1 DUSP6 PCNA OCLN-1 KLK15 CPT1A MTOR RPS6KA4 RPS6KA5 TP53 PARP1 PPARGC1A LDHA EGR1 PDCD4 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260211%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders H2BC21 ACD H2BC5 TINF2 H2BC1 H4-16 H2AZ2;H2AZ1 TERF2 H2AJ H2BC15;H2BC3;H2BC11;H2BC12 H2AC14 H2AC20 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TPP1 H4C1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TERF1-1 H2AB2;H2AB3;H2AB1 H4C6 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260211%WP1601%HOMO SAPIENS Fluoropyrimidine activity PPAT FPGS UPP1 MTHFR TK1 RRM1 ABCC5 SLC22A7 GGH UPB1 DHFR2;DHFR CYP2A13;CYP2A6;CYP2A7-1 SMUG1 UCK1 ERCC2 UMPS SLC29A1 RRM2-1 TYMS ABCC4 XRCC3 CES2 CES1 ABCG2 TP53 ABCC3 TDG DPYD CDA DPYS TYMP SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260211%WP4814%HOMO SAPIENS Somatic sex determination WNT4 SOX8 DMRT1 DHH FOXL2 PTGDS GATA4 CTNNB1 NR5A1 FGF9 WT1 SRY SOX9 RSPO1 AMH ZFPM2 PDGF PATHWAY%WIKIPATHWAYS_20260211%WP2526%HOMO SAPIENS PDGF pathway NFKBIA MAP2K2;MAP2K1 STAT3 SHC1-1 ARFIP2 PAK1 PIK3R1 MAPK8 TIAM1 PDGFRB STAT1 GRB2 PDGFA FOS SOS1 CHUK SRF WASL MAPK1 MAP3K1 RASA1 MAPK3 PDGFB ELK1 RHOA PLCG1 MAP2K4 JUN RAF1 NFKB1 HRAS CDC42 VAV1 VAV2 SRC PLA2G4A RAC1 JAK1 PTPN11 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260211%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease LMNB1 DES LBR MYOD1 LMNA H2AZ2;H2AZ1 ACTA1 NOTCH3 MEF2C MYOG CBX5 DMPK HP1BP3 HSPB2 HSPB3 AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260211%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension FTCD UROC1 AMDHD1 GLUD1;GLUD2 HAL GPT2 MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids ASAH2 S1PR1 S1PR3 PLD1 CERK NFKB1 MTOR IGF1R SPHK2 AKT1 PIK3CA HIF1A TSC1 CERS1 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation CD40 ID3 STAT3 E2F1 IL21R STAT6 IL4R TLR8 TLR3 BCL6 MEF2C CDKN1A LOC102723996;ICOSLG CCND2 TNFRSF13C MYC BCR TLR5 TLR9 TLR7 MEF2B;BORCS8-MEF2B SYK CDKN2A TLR4 LYN SPI1 SPIB BCL2L1 CD79B NFKB1 TLR2 CD79A SLAMF1 POU2F2 IL6 TLR1 IRF4 POU2AF1 IRF8 TLR10 TCF4 TLR6 CDKN1B CCND3 EZH2 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PTK2 NRAS MAP2K2;MAP2K1 STAT3 STRN GAB1 MAPK8 GRB2 HGF SOS1 RAP1A SOS2 MET PIK3R3 PAK2 PLCG1 RAF1 JUN BUB1B-PAK6;PAK6 ETS1 ARAF ELOA INSL3 TFE3 RAC1 PRCC RPL11 PAK3 PAK5 PAK4 C8orf34 PAK1 PIK3CD PIK3R2 PIK3R1 PIK3CB RAP1B ALK CDKN1A AKT2 AKT3 MAPK1 AKT1 CRKL PIK3CA MAPK3 CRK BRAF RAPGEF1 JAK3 KRAS BAD HRAS CDC42 SRC CBL PTPN11 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway PARP1 AIFM1 MIF ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260211%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R15A PPP1R15B DDIT3 PPP1R13B BCL2 PPP1R11 EIF2S1 PPP1R10 PPP1R8;STX12 PPP1R2-1 PPP1R16B ATF6 MBTPS1 PPP1R14A PPP1R14B MAPK8 PPP1R12A PPP1R14C PPP1R16A PPP1R9A PPP1R3G PPP1R3F PPP1R1A PPP1R3C PPP1R3B ATF4 PPP1R3E PPP1R1C PPP1R1B PPP1R3D PPP1R12B MAP1LC3A XBP1 PPP1R14D PPP1R7 EIF2AK1 PPP1R12C MBTPS2 EIF2AK3 EIF2AK2 PPP1CA ERN1 PPP1CB PPP1CC HSPA5 PPP1R3A LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260211%WP3601%HOMO SAPIENS Lipid particles composition APOA2 APOA1 APOE LCAT APOB LPL APOC2 LDLR APOC3 CETP LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2874%HOMO SAPIENS Liver X receptor pathway SREBF1 NR1H3 CYP7A1 FASN RXRA CYP2B6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCG8 ABCG5 SCD IL9 SIGNALING%WIKIPATHWAYS_20260211%WP22%HOMO SAPIENS IL9 signaling STAT5A STAT5B IL9R CDK9 STAT3 IL2RG MAP2K2;MAP2K1 JAK3 PIK3R2 PIK3R1 STAT1 GRB2 IL9 MAPK1 JAK1 MAPK3 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2877%HOMO SAPIENS Vitamin D receptor pathway TGFB2 TGFB1 HNF1A KLF4 HIF1A SFRP1 JUNB TREM1 THBD CCNE1 BDKRB1 TNFRSF11B IRF4 IRF8 KNG1 CD40 IL25 CEBPA IL12A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2D6;LOC107987479;LOC107987478-1 CDKN1A MYC CDKAL1 TRAK1 STS ITGAM FOXO1-1 CYP7A1 STEAP4 LPGAT1 GXYLT2 CDK2 PRDM1 NRIP1 CLDN2 TRPV6 NOX1 KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 SALL4 SPRR1A;SPRR1B TNFSF11 KRT16;KRT14 EPHB4 KRT71 LGALS9C;LGALS9;LGALS9B SLC34A2 SLC8A1 S100A2 MED9 CDC34 NINJ1 S100A4 CCND1 SULT2A1-4 S100A9 S100A8 COL13A1 CLEC16A RASGRP1 KLK6 IGFBP1 CCNC-1 CRACR2A CRACR2B IGFBP5 DND1 BTLA CD14 IGFBP3 FGF23 KL SLC37A2 KRTAP8-1 STAM BMP6 TNFSF4 EFNA5 CYP2S1 TRPV5 PNOC CLPTM1L IGSF9B MXD1 PRKCQ CD200 TNFAIP3 ORM2;ORM1 ADAMTS5 SULT1C2 CASP14 PTGER4 DUSP10 ADGRE5 DACT2 TIMP2 TIMP3 CTLA4 GADD45A SOSTDC1 CA9 ADRB2 ABCD1 CAMP CDKN2A SERPINB1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 IRF5 COLEC11 SATB1 PTH SEMA3B ASAP2 ALPG;ALPP;ALPI-1 ATP2C2 ID1 CST6 PTHLH IL1RL1 CLMN CREG2 DNER HSD17B2 CDKN2D LRRC25 S100G CDKN2B CDKN2C CYP27B1 CDX2 KRT13 G0S2 RXRA MYO9B DEFB132 CASP5;CASP4 G6PD CYP24A1 VDR KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 CD9 TPM1 CDKN1B CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 DEFB4A;DEFB4B PPARD ATP2B1 SPP1 CYP2B6 SLC2A4 CYP2C9;CYP2C19 ADRA1B BCL6 S100A6 CBS;CBSL ALOX5 NFATC2 LRP5 CYP1A1 ABCB1 LRRC8A ID4 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260211%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins GRIK2 GPHN KCNQ2 RAP1GAP CHL1 EPB41L1 GABRG3;GABRG2 EPB41L2 NCDN EFNA5 NEO1 CLASP1 MAPK9 NTNG1 GABBR2 KCNJ6 CADM3 CAV2 APLP2 GRIN1 KCNMA1 ANK3 SNW1 MAPK4 DAB1 AGRN PRKCZ GRIN2B CASK CDH2 STX2 CAMK2G PLCB4 TERF2IP CADM1 EPB41 STXBP2 CLSTN1 ATP2B1 CSN3 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260211%WP4191%HOMO SAPIENS Caloric restriction and aging SIRT1 TP53 NAMPT PRKAB2 PPARGC1A AKT1 MTOR IGF1 EGF EGFR SIGNALING%WIKIPATHWAYS_20260211%WP437%HOMO SAPIENS EGF EGFR signaling ABI1 FOSB PTPN5 BCAR1 STAT3 PLD1 AP2A1 GAB1 JUND MAPK9 MAP4K1 MAPK8 GRB2 AP2M1 SOS1 MEF2A ARF6 MEF2C RASA1 MEF2D MAP3K2 MAP3K1 DNM1 ELK1 STXBP1 STAT5A RPS6KA3 STAT5B MAP3K4 AP2S1 AP2B1 STMN1 CFL1 PRKCI PIK3R2 PIK3R1 NEDD4 MAP2K5 MAPK1 AKT1 BRAF CRK FOXO1-1 ROCK1 MAPK7 RPS6KB1 MAP3K3 KRAS ATF1 RPS6KA1 RPS6KA2 JAK2 PIAS3 HRAS GAB2 VAV1 VAV2 GJA1 SRC ERBB2 EIF4EBP1 PTPN11 PRKCB PTK2 RALA-1 PRKCD PRKCA STAM PIK3C2B MAP2K2;MAP2K1 SHC1-1 PDPK1 RAP1A MAPK4 ABL1 PXDN SOS2 PRKCZ EGF PLCG1 RAF1 JUN SP1 PTEN RAC1 JAK1 SPRY2 NCOA3 EGFR PAK1 E2F1 STAT1 CAV2 FOS USP6NL CREB1 SH3GL3 ERRFI1 NDUFA13 PEBP1 EPS8 CRKL ELK4 PLCE1 SH3GL2 USP8 DOK2 HGS STAMBP MAPK14 RIN1 CAMK2A STAM2 INPP5D FOXO4 IQGAP1 PTK2B PLD2 ATXN2 RAB5A PCNA RALGDS IQSEC1 TNK2 CAV1 PTK6 MTOR INPPL1 SYNJ1 CBLC PTPRR CBLB SH3KBP1 CDC42 NCK2 NCK1 RPS6KA5 VAV3 GRB10 RALBP1-1 EPS15L1 NOS3 EPN1 PLSCR1 ARHGEF1 RALB ASAP1 REPS2 CBL CSK RICTOR EPS15 LIMK2 PTPN12 ITCH SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260211%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS2 ACSL1 FADS1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX5 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260211%WP5601%HOMO SAPIENS Caffeine in blood vessels PDE3B RYR3 MYLK PDE4A GUCY1A2 ADORA2B PDE4B ADCY9 ADRA1B PPP1R12A ADRA1A ADORA2A PPP1R12C PDE3A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PDE4D-1 ADCY6 ADCY5 PPP1CB ADRA1D NOS3 CALM3;CALM1 CALM1 CALM2 GUCY1A1 RYR2 ADORA3 NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2064%HOMO SAPIENS Neural crest differentiation NFKB2 HDAC10 HDAC11 CDH7 MPZ HOXA1 MSX2 MIA MITF ISL1 FGFR3 HOXB1 NOTCH2 NOTCH3 CTBP2 NOTCH1 DLX5 NOTCH4 PHOX2B GJB1 TLX2 BMP7 LHX2 LHX1 LHX5 TFAP2E;TFAP2B BMP4 DMBX1 ZIC1 FOXD3 OLIG3 PAX3 DCT PAX7 HAND1 HDAC6 PRTG GBX2 GFAP MSX1 TBX6 PMP22 NEUROG1 HES1 HES5 RHOB TCF4 TCF7L1 ETS1 HDAC2 TFAP2A MYC FZD3 ITGB1 MYB COL2A1 RBPJ COL11A2 FGF8 SOX9 FGFR1 HEY2 WNT8A DLL1 DLL3 DLL4 CTNNB1 SMAD1 FGF19 ASCL1 MBP CDH6 FGFR2 CDH2 CDH1 SOX5 ID1 NFKB1 SNAI1 SNAI2 OLIG1 OLIG2 SOX10 DVL1 DVL2 DVL3 WNT1 WNT3A GSK3B HDAC1 AXIN1 AXIN2 HDAC4 HDAC5 HDAC8 HDAC9 HDAC7 HDAC3 FGF2 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260211%WP5398%HOMO SAPIENS NRXN1 deletion syndrome GRIN2C GRIN2B DLG4 GRIN2D NLGN4X;NLGN4Y NRXN1;NRXN3;NRXN2 GRIA2 GRIN3B GRIN3A GRIN2A GRIA3 GRIN1 GRIA4 GRIA1 NLGN3 NLGN1 NLGN2 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260211%WP4971%HOMO SAPIENS Phosphoinositides metabolism PIK3C2G PIK3C2A PIK3C2B PLCG2 PLCG1 MTMR12 MTMR10 MTMR11 PIP4P2 PTEN PIP4P1 PLCZ1 PIP4K2B PIP4K2C SBF1 SBF2 SACM1L OCRL MTMR1 MTMR2 PIP4K2A MTMR3 MTMR8 MTMR9 MTMR4 MTMR6 MTMR7 MTM1 PIP5K1A PIP5K1B PIP5K1C PIKFYVE PLCH1 PIK3R4 PLCH2 PIK3CD PLCD3 PLCD4 PIK3CB PLCB3 PIK3CA PLCE1 PIK3C3 INPP5D PIK3CG PLCB4 PLCB1 PLCD1 PLCB2 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260211%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit CD3E CD3D CD80 BCL2 IL2 SPN CD27 CD86 CD3G CD28 CD247 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260211%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM BLM BID MDM2-2 ABL1 RNF8 CDKN2A ATM ATR BRCA1 BRCA2 FANCD2 NBN SMC1A CDK5 CDC25C E2F1 BAK1 CASP9 CASP3 RAD50 MDC1 APAF1 DCLRE1C RAD52 RAD51 RIF1 RASSF1 SMC3 KAT5 RAD17 TP73 TRIM28 EXO1 RAD9A UPF1 ACTL6A MCPH1 TRAF6 YAP1-1 HSF1 TP53BP1 NABP2 BAX PCNA ATF2 MRE11 TERF2 TP53 PARP1 CHEK2 PRKDC CHEK1 STK3 LATS1 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260211%WP430%HOMO SAPIENS Statin inhibition of cholesterol production APOE APOC2 APOC3 ABCG8 ABCG5 LRP1 CYP7A1 PDIA2 DGAT1 APOA5 SQLE SOAT1 APOC1 SCARB1 LPL MTTP CETP HMGCR APOA2 APOA1 LCAT APOA4 LIPC ACSS1 FDFT1 APOB LDLR PLTP ABCA1 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260211%WP2882%HOMO SAPIENS Nuclear receptors meta pathway TGFB2 TGFB1 SOD3 STAT3 NFKB2 HSPA1A;HSPA1B PDK4 ACADM CCL13;CCL2 GSTM1;GSTM2-1 CUL1 GSTA3;GSTA1 FASN APOA2 GSTA3;GSTA5;GSTA1;GSTA2 APOA1 SLC27A5 PCK1 AMIGO2 PLTP PTPA ACAA1-1 PSMC5 IL12B IL12A IFNG IL17B MYC CDC37 EPHA2 FOXO1-1 APOA5 BAX CDK4 GCC1 SCP2 TNS4 SLC6A17 SLC6A16 SLC6A15 SLC6A14 SLC6A13 SLC6A11 SLC5A6 SLC5A7 SLC5A9 CES3 EPHA3 RGS2 ABCB4 SRC MGST3 POU5F1;POU5F1B MGST2 SLC5A3 SLC5A4 SEC14L1 PRDX1 IGFBP1 SLC19A2 GSTM3 PLK2 SMARCA1 PRDX6 SLC6A5 SLC6A6 SLC6A7 SLC6A8 SLC6A9 CPEB4 SLC6A1 SLC6A2 EPB41L4B AKAP13 ENC1 ANKRD1 NCOA1 FGFBP1 SERPINB2 EDN2 SLC2A11 NCOA6 SLC2A10 TSC22D3 SLC2A13 SLC2A12 MYOF SLC39A11 FGF19 SLC39A10 SLC39A13 SERPINB9 SLC39A12 FGF13 BAAT SLC7A5 B3GNT5 HSP90AB1 CDC42EP3 SLC6A3 AHRR PMP2 ANGPTL4 MFGE8 HBEGF JUN GSTP1 NR1I3 NR1I2 SNAI2 FGD4 SRPX2 GPR153 HSP90AA1 DNER SERTAD2 SP1 CBR3 CAP2 CCL20 CAVIN2 NR1H4 CYP8B1 MAFF KTN1 FABP1 TXN RXRA GSTA4 ETNK2 GGT1 CBR1-1 SLC27A1 G6PD NR3C1 VDR ACKR3-2 GSR SLC39A9 CDKN1B SLCO2B1 SLC39A6 SLC39A5 SLC39A7 SLC39A2 SLC39A1 GCLC SLC39A4 SLC39A3 AIP PGD ALDH3A1 NFE2L2 SMC1A SCNN1A FKBP5 CYP2B6 SLC26A2 CYP2A13;CYP2A6;CYP2A7-1 ABHD2 PDE4B CYP2C9;CYP2C19 CES5A IP6K3 DNAJC15 EHHADH-1 SLC2A9 ALAS1 SRXN1 GADD45B SLC2A5 SLC2A1 SLC2A6 SLC2A2 SLC2A7 SLC2A8 ARL5B SLC7A11 IL1B CDK1 CPT2 ZIC2 ME1 POLK SRGN ABCC4 TGFBR3 DNAJC7 FTH1 NAV3 SLC39A8 ADGRF4 SLC6A19 BLVRB BIRC2 ABCC2 BIRC3 SLC6A18 PTGES3-1 SLC5A11 ALOX5AP SLC5A1-1 SLC5A12 SLC5A10 PRRG4 SLC5A8 STOM TXNRD3 SLC39A14 KLK15 SPRY1 S100P CPT1A ABCB1 PPARGC1A HMOX1 EGR1 SLC5A2 SLC6A20 SLC5A5 FTL-1 TXNRD1 GCLM ABCC5 IL11 NCOA2 JUND SLC6A4 PPARA NR1H3 JUNB SERPINA1 KAT2B THBD HES1 NR0B2 KEAP1 GPAM CYP1A2 CYP1B1 MAFG EP300 SREBF1 PTGS2-2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PPP1R14C BHLHE40 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ARNT SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 APOC3 ABCG8 ABCG5 SCD CYP7A1 NRIP1 SQSTM1 AHR CCND1 SULT2A1-4 GSTM4 CDKN1C HGF TNFAIP3 NRG1 IRS2 TNF PDGFB TGFA ESR1 CES2 CES1 AGER PTGR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ACOX1 NCOA3 PPARD TGFBR2 EGFR SLC2A4 IL2 MGST1 NQO1 DNAJB1 UGT1A1;UGT1A6 GSTT2B;GSTT2 CYP1A1 LRRC8A ABCC3 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC10A1 ABCB11 NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP61%HOMO SAPIENS Notch signaling STAT3 HEY2 DLL1 DLL3 NCOR1 DLL4 NOTCH2 NOTCH3 NOTCH1 NOTCH4 TLE1 FBXW7 ADAM17 NFKB1 PSEN2 PSEN1 HES1 HES5 CUL1 HDAC2 EP300 GSK3B SKP1 PIK3R2 HDAC1 PIK3R1 APH1A NCSTN APH1B SNW1 AKT1 LCK JAK2 MAML2 MAML1 MTOR FHL1 RBPJ CIR1 PSENEN RING1 SAP30 NCOR2 NUMB MAML3 NUMBL SRC DTX1 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 HES6 SPEN JAG2 JAG1 ITCH DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260211%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control UFD1 PMPCB PMPCA UBXN6 SLC25A46 AFG3L2 OXA1L VCP-1 PPA2 CLPP YME1L1 MICU1 HTRA2 DNM1L SPG7 MFF TIMM50 HSPD1 PITRM1 MSTO1 MFN1 MARCHF5-1 DNAJC19 TIMM8A TIMMDC1 C1QBP AGK USP9X STAT2 TMEM126A-1 PYCR2 PYCR3 GFER COQ5 COQ3 PINK1 NPLOC4 XPNPEP3 SFXN4 RTN4IP1 PRKN HSPA9 AIFM1 PYCR1 ATAD3A;ATAD3B MCL1 TRAK1 PLEK MFN2 TXN2 TXNRD2 MIPEP UBXN1 CLPB MICOS13 OPA1 OPA3 GDAP1L1 LONP1 SACS T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260211%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 NFKBIA IFNAR1 MAP2K2;MAP2K1 CD4 PDPK1 PRKCQ GRB2 SOS1 ITPR1 TNF CTLA4 CDKN2A HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PLCG1 IRF2BPL GRAP2 RAF1 JUN TYK2 LTA NFKB1 LCP2 CARD11 BCL10 MALT1 CCL19 PTPRC HLA-DRA CCL28 LAT IL18R1 PTEN CD86 IL23R CD80 MYD88 IKBKG IL12B GSK3B IL12A STAT4 PIK3CD PIK3R1 IL12RB1 IFNG IL12RB2 CD3G IL23A RPTOR FOS CD28 CD247 CD3E DEPTOR CD3D CHUK MLST8 NFATC1 IL2 CDKN1A IL4 IFNB1-4 IL17A MAPK1 AKT1 MAPK3 ICOS BAX RHEB LCK BCL2L1 IKBKB JAK2 MTOR PPP3CC HRAS ZAP70 TP53 CCND1 FOXO3 RASGRP1 RICTOR IFNAR2 TSC2 TSC1 FYN RELA TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260211%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC LATS2 TEAD1 TEAD2 TEAD3 PRKAG1 PRKAG2 CCN1 PRKAA2 PRKAG3 RHO CCN2 PRKAB2 PRKAB1 RHOA YAP1-1 PRKAA1 HMGCR RHOB STK4 SAV1 RHOC RHOD MOB1A;MOB1B TEAD4 STK3 LATS1 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260211%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 AGTR1 ADAM17 AVPR1B ACE2 ENDOMETRIAL CANCER%WIKIPATHWAYS_20260211%WP4155%HOMO SAPIENS Endometrial cancer FGFR1 NRAS MAP2K2;MAP2K1 PDPK1 GRB2 SOS1 FGFR3 CTNNB1 SOS2 PIK3R3 GADD45A ELK1 EGF FGFR2 CDH1 RAF1 LEF1 TCF7 TCF7L2 TCF7L1 PTEN ARAF ILK CTNNA1 CTNNA3 CTNNA2 EGFR DDB2 GSK3B PIK3CD PIK3R2 PIK3R1 BAK1 PIK3CB CASP9 FOS GADD45B GADD45G AXIN1 CDKN1A AKT2 MYC AKT3 AXIN2 POLK MAPK1 AKT1 PIK3CA MAPK3 BRAF BAX KRAS BAD APC FGF1 HRAS APC2 TP53 CCND1 FOXO3 ERBB2 FGF2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260211%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction IRF9 NFKBIA IFNAR1 TBK1 MYD88 IKBKG DDX58 IFIH1 MAPK8 STAT1 IRF3 FOS CHUK MAVS STAT2 TRAF3 TLR7 TRAF6 EIF2AK2 MAPK14 JUN TYK2 NFKB1 IKBKB MAP3K7 JAK1 RIPK1 IFNAR2 TICAM1 IKBKE OAS1 OAS3 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260211%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway RALA-1 TGFB2 PRKCD TGFB1 TGFB3 MAP2K2;MAP2K1 STAT3 PLD1 MAPK10 MAPK9 MAPK8 SMAD2;SMAD3 PIK3R3 GADD45A TGFA CDKN2A PAK2 SMAD4 EGF RPS6KB2 RAF1 NFKB1 BUB1B-PAK6;PAK6 ARAF BRCA2 RAC1 JAK1 PAK3 PAK5 PAK4 TGFBR2 RAC3 RIPK4 ARHGEF6 E2F2 IKBKG EGFR DDB2 PAK1 E2F1 PIK3CD PIK3R2 TIAM1 PIK3R1 BAK1 PIK3CB STAT1 CASP9 VEGFA TGFBR1-1 GADD45B CHUK GADD45G RAD51 CDKN1A AKT2 AKT3 PEBP1 POLK MAPK1 AKT1 PIK3CA MAPK3 RHOA BRAF BAX RPS6KB1 CDK4 DUSP6 KRAS RALGDS BCL2L1 IKBKB BAD MTOR RB1 CDC42 CDK6 E2F3 TP53 RALBP1-1 CCND1 RALB ERBB2 RELA TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260211%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome AFMID IDO2 IDO1 KYAT3 KYAT1 GOT2-1 IL6 DDC IFNG TDO2 IL1B IFNB1-4 AADAT TNF HAAO KMO KYNU HEART DEVELOPMENT%WIKIPATHWAYS_20260211%WP1591%HOMO SAPIENS Heart development HEY1 BMP10 HEY2 GATA6 TBX20 SMYD1 TBX1 FOXH1 IRX4 BHLHE40 TBX5 VEGFA TBX2 HAND2 ISL1 GATA4 NFATC1 CTNNB1 NOTCH1 MEF2C SRF FOXC2 NKX2-5 FOXC1 MAPK1 SMAD1 BMP4 SHH ERBB3 PITX2 NFATC3 FGF10 SMAD4 NFATC2 NFATC4 HAND1 BMPR1A BMPR2 VEGFB VEGFC FGF8 FOXA2 BMP2 PTPN11 SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260211%WP4658%HOMO SAPIENS Small cell lung cancer CYCS-1 PTK2 COL4A4 NFKBIA COL4A6 NFKBIB FN1 CDKN1C BID MAX ITGA2B LAMC1 CASP8 PIK3R3 GADD45A ITGA2 LAMC3 LAMC2 CCNE1 NFKB1 ITGAV LAMA5 ITGA3 CDKN2B PTEN RXRA ITGA6 CDKN1B LAMA2 LAMA1 LAMA4 LAMA3 BCL2 E2F2 IKBKG LAMB3 DDB2 SKP1 CCNE2 PTGS2-2 LAMB2 E2F1 PIK3CD PIK3R2 LAMB1 PIK3R1 BAK1 PIK3CB CASP9 CASP3 GADD45B CKS1B CHUK APAF1 TRAF1 GADD45G TRAF4 TRAF2 COL4A3 CDKN1A AKT2 TRAF5 MYC CKS2 AKT3 RARB POLK COL4A5 AKT1 TRAF3 BIRC7 PIK3CA FHIT RXRB TRAF6 RXRG ZBTB17 LAMB4 BIRC2 BIRC3 BAX CDK4 ITGB1 CDK2 BCL2L1 NOS2 IKBKB RB1 CDK6 E2F3 TP53 CCND1 COL4A2 RELA COL4A1 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer TGFB2 LATS2 TGFB1 TGFB3 ID2-1 FN1 MAPK8 SMAD2;SMAD3 GRB2 SOS1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 FOXC2 MEF2D PIK3R3 HIF1A MAP2K3 MMP2 MAP2K4 MAPK12 MAPK13 MAPK11 MMP15 FZD10 PROX1 EZH2 TJP1 PIK3R2 PIK3R1 TGFBR1-1 CLDN6 FOXM1 COL4A3 FZD1 AKT2 WNT10B WNT10A AKT3 FZD3 COL4A5 MAPK1 AKT1 FZD2 FZD5 MAPK3 FZD7 FZD6 TRAF6 FZD9 SPARC TUSC3 FZD8 DLK1 PDCD6 CLDN1 FOXQ1 CDKL2 CLDN3 CLDN9 KRAS CLDN2 CLDN8 CLDN7 PKP2 PKP1 EIF5A2 TWIST2 RBPJ JUP CLDN23-1 HRAS NRP2 PKD1 CLDN20 DSP EED CLDN22;CLDN24-1 CLDN11 CLDN10 CLDN15 CTDSP1 CLDN14 CLDN12 JAG2 CLDN19 JAG1 STRAP FZD4 CLDN18 CLDN17 COL4A2 CLDN16 COL4A1 TMPRSS4 NR2C2 COL4A4 SUZ12 COL4A6 GDF15 NUBPL MPP5 MAP2K2;MAP2K1 CRB3 SHC1-1 FMNL2 WNT9B WNT9A WNT8A WNT8B DLL1 DLL3 WNT7B DLL4 WNT7A CTNNB1 ZEB1 SOS2 MMP9 ZEB2 WNT5B WNT5A SMAD4 CDH2 CDH1 RAF1 ID1 SNAI1 SNAI2 WNT6 RBBP4 ITGA5 VTN WNT1 TGFBR2 WNT2 WNT3 WNT4 WNT3A GSK3B PAK1 WNT2B PIK3CD PIK3CB WNT16 PIK3CA CLDN5 MAP2K6 MAPK14 LRP5 LRP6 WNT11 OCLN-1 CLDN4 TP53 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260211%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRB UQCC3 UQCC2 UQCC1 BCS1L UQCR11 UQCR10 TTC19 UQCRQ LYRM7 UQCRC1 UQCRFS1 CYC1 UQCRC2 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260211%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system SGK1-1 PARK7 HDAC11 VHL MAPK8 SMAD2;SMAD3 TUBA1C GRIA1 SGK3;C8orf44-SGK3 PXN HIF1A SHH PPP1CA DLG4 BDNF HDAC6 TUBA4A TUBB3;TUBB6 PRKN GRIA2 TUBA3E;TUBA3C-1 SNCA HSPA8 CSNK2A2 HSPA4 MDH1 EP300 MIF CSNK2B SNCAIP DLG2 TUBB4A;TUBB;TUBB8B;TUBB8 STUB1 APOE KAT5 MAPK1 AKT1 OPTN-1 MAPK3 DCTN1 HSF1 RHOT1 SMAD7 BAX SQSTM1 POU5F1;POU5F1B MAPT PRDX1 PRKCE VCP-1 CTNNB1 CDC20 MAP1B ERG CFTR KALRN PRKCZ PRDX2 ATXN3 GRK2 UBD G3BP1 EP400 TPPP MAP3K5 CCDC141 PROM1 NDUFV1 CYBB XRCC6 FUS ISG15 BBIP1 CNOT6 DNAJA1-1 MAPRE1-1 ACTR1A SIRT2 VIM HSP90AA1 CTTN SP1 BIRC5 MYH9 GSK3A DYNC1I2 ITIH4 NEDD9 HTT MIIP ELP1 ELP3 ARID3A GARS1 ATP13A2 RAC1 NR3C1 BCL2 MYD88 EGFR AURKA GSK3B FOXP3 HSPB1 TARDBP MAP1LC3A HDAC9 RAD23B SOD1 PTK2B APC MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260211%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 CSN2-1 CEBPA GAL CEBPB NFIB ELF5 NFIC ORAI1 EGFR PGR HDGFL2 EIF4G1 TFPI2 CHUK NRG1 CLDN6 MYC ERBB3 ESR1 EIF4E STAT5A STAT5B NFIA PRL NFIX ATP2C2 BCL2L1 JAK2 TNFSF11 CAV1 PRLR CCND1 USF1 PNCK NR3C1 YY1 TPM3 ERBB4 ERBB2 DLGAP4 USF2 ESR2 PTPN1 TTC9 TNFRSF11A GJB2 TP53 NETWORK%WIKIPATHWAYS_20260211%WP1742%HOMO SAPIENS TP53 network BCL2 BAX ATM SUMO1 TNFSF10 OTX2 BID BOK MDM2-2 PMAIP1 TP53 TP63 CDKN1A ABL1 MYC TP73 GADD45A CDKN2A BBC3 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260211%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease DOCK6 CYBC1 DLL4 NCF1 TLR8 NCF4 COX4I2 CXXC5 DGUOK NOTCH1 CHCHD2 NOTCH4 KCNN3 C4orf54 GTF2I MAPK1 BEND6 TLR9 EFL1 MAPK3 CYBA SHCBP1 IBTK ARHGAP31 EIF6 NCF2 ESR1 EOGT SBDS BTK CYBB NFKB1 RBPJ SP1 CDC42 NOX3 RAC1 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260211%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease SP3 KCNN3 CALM1 SP1 ESR1 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260211%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects PRDM16 FGFR1 DUOX2 SLC16A10 MAFA TSHR PFKFB2 TG MAP2K2;MAP2K1 SLC26A4 PNPLA2 FRS2 NPY ITGB3 MDM2-2 TBC1D4 FGF21 GRB2 SOS1 POMC CTNNB1 NOTCH1 ITPR2 MAP4K5 SHH RAF1 AGRP ITGAV KDM1A TPO RXRA WNT4 PRKACA-1 GSK3B CASP9 RPTOR CREB3 MLST8 PRKG2 AKT3 MAPK1 PIK3CA RPS6 FOXO1-1 MAPK14 KLB ADCY3 RPS6KB1 THRB RHEB THRA TRH AKT1S1 ADCY8 ATF2 TTF2 TTF1 MC4R BAD NPPB NHSL1 MTOR IYD DUOXA2 HRAS SLC16A2 TSHB RPS6KA6 ACTL6B SECISBP2L TP53 DIO1 DIO3 SIRT6 SRC LOC100509620;LOC112267859;AQP7 PPARG PPARGC1A SLCO1C1 PAX8 MAPKAPK3 ADRB3 SLC5A5 ZNF516 PLIN1 TSC2 MGLL TSC1 KDM3B NPR1 UCP1 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260211%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells PRKCD MAP2K2;MAP2K1 PRKCA EIF4A2 PRKACA-1 EIF4A1 MAPK10 EIF4G1 PIM1 PIK3R2 MAPK9 PIM2 PIK3R1 MAPK8 EIF4G3 PIK3CB RPTOR MAP2K5 AKT2 EIF4B AKT3 MAPK1 AKT1 PIK3R3 MAPK3 PIK3CA MAP2K6 RPS6 EIF4E MAPK14 RPS6KB1 RPS6KB2 MAP2K3 MAP2K4 PIK3CG RPS6KA1 RPS6KA2 MTOR RPS6KA4 RPS6KA5 CSNK2A1;CSNK2A3 EIF4EBP1 PDCD4 MAP2K7 PDK1 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260211%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling NFKBIA TEC RELB MAP2K2;MAP2K1 STAT3 NFKB2 STAT4 MAPK9 MAPK8 STAT6 YES1 STAT1 TSLP FES CRLF2 MAPK1 AKT1 MAPK3 IL7R RPS6 HCK STAT5A MAPK14 STAT5B BTK LYN LCK NFKB1 JAK2 GAB2 SRC JAK1 EIF4EBP1 FYN RELA PTPN11 SPINA BIFIDA%WIKIPATHWAYS_20260211%WP5150%HOMO SAPIENS Spina bifida AHCYL2 MTHFD1 SHMT1 MTHFR MAT2B DNMT1 AHCY DNMT3B MAT1A DNMT3A MTRR MTR-1 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome TEC PNMT FNDC8 DHRS11 PGAP3 SLC35G4;SLC35G5;SLC35G3;SLC35G6 CWC25 SLFN11;SLFN13 PIGW AATF LHX1 IKZF3 CISD3 CCT6B DUSP14 CCL3L1;CCL3L3;CCL3;CCL18 RDM1 LASP1 ARL5C MMP28 CCL13;CCL2 C17orf98 C17orf50 CCL11 GPR179 MED1 STARD3 UNC45B RPL23 LIG3 CCL5 CCL23;CCL15 DDX52 LYZL6-1 MRPL45 SRCIN1 CACNB1 RAD51D SLFN14 ACACA ZNF830 AP2B1 CCL14 SLFN5 GRB7 GGNBP2 PIP4K2B FBXO47 MLLT6 FBXL20 NEUROD2 CCL4L2;CCL4L1;CCL4 CCL8 MIEN1 ZNHIT3 C17orf78 CCL1 RFFL ASIC2 SOCS7 GAS2L2 CCL16 HEATR9 TMEM132E TAF15 RASL10B SYNRG PCGF2 EPOP PEX12 MYO19 PLXDC1 NLE1 ARHGAP23 TADA2A STAC2 TCAP SLFN12L;SLFN12-1 CDK12 PPP1R1B HNF1B ERBB2 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome MTMR6 MTMR7 MSRA CGAS SLC2A4 TBX5 HSPD1 SGPL1 GATA4 PPP1R3B CTNNB1 AXIN1 BLK SLC35G4;SLC35G5;SLC35G3;SLC35G6 CSTA NKX6-1 NUMA1 TNKS MAPK1 PINX1 HEPACAM2 MAPK3 SOX7 CTSB PDX1 S100A10 BMP1 MEPE C8orf74 DEFB135 RP1L1 MFHAS1 TLR4 FAM167A MCRS1 NEIL2 XKR6 RAF1 TLR2 CTSD CLDN23-1 FDFT1 SLBP TERT TERF1-1 ERI1 MTMR8 MTMR9 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5402%HOMO SAPIENS 10q22q23 copy number variation SNCG C10orf99 RSPH4A GPR15 SUSD2 AFG3L2 WAPL RSPH3 MAD2L2 STAG1 TSPAN14 RSPH1 LRIT2 SHLD3 LRIT1 ADAM10 MAS1 PRXL2A SHLD2 SHLD1 CCSER2 NFKB1 BMPR1A BMP2 ERBB4 CEBPA SMC1A GLUD1;GLUD2 OPN4 VEGFA SH3GL3 SMC3 SH2D4B ADIRF BUB1B LDB3 GHITM TNFSF11 IQUB ROPN1L FAM25A;FAM25C;FAM25G;FAM25E-1 RSPH6A GRID1 ACTN2 SIRT4 DNAJB13 NME5 NRG3 CDHR1 PPARG MMRN2 DYDC2 MAT1A DYDC1 ZMYND11 RGR SF3B4 RSPH9 PDS5B PDS5A RAD21 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260211%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells TP53 RPIA RPE;RPEL1 TALDO1 PGLS DERA G6PD OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260211%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators TGFB1 IL11 TSLP IL9 CCL13;CCL2 CCL11 MMP3 CX3CL1 LTA CCL5 CCL23;CCL15 CCL19 CCL28 CCL14 CCL4L2;CCL4L1;CCL4 CCL8 CCL1 IL25 TNFSF13B CCL16 IL12B IL12A CSF2 CXCL11 IFNG IL23A IL17F IL17D IL17C IL17B IFNB1-4 IL17A IL18 OSM IL1A CSF3 EPO IL7 CSF1 CXCL9 AREG IL1RN CXCL17 TNF CXCL2;CXCL3;CXCL1-1 CXCL13 MMP9 CXCL14 CXCL10 IL36A IL36B PF4;PF4V1-1 CCL3L1;CCL3L3;CCL3;CCL18 EBI3 IL36RN CNTF XCL1;XCL2 IL36G PPBP IL1F10 IL20 IL26 IL24 IL27 NFKB1 IL19 IFNK CTF1 LIF IL6 IFNL2;IFNL3;IFNL1 CCL17 CCL25 IL33 CCL24 CCL20 IL31 CCL22 CCL21 IL37 CCL27 CCL26 MMP1 IL21 IL22 SPP1 IL10 VEGFA CXCL12 IL13 IL2 IL4 IL1B IL5 CXCL8 CXCL5;CXCL6 IL3 IL15 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260211%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis CYCS-1 BCL2 BAX PRF1 CASP7 HTRA2 BAK1 BID CASP9 CASP3 FAS FADD APAF1 ENDOG FASLG DIABLO-1 CASP8 CFLAR CASP6 AIFM1 TRANSLATION FACTORS%WIKIPATHWAYS_20260211%WP107%HOMO SAPIENS Translation factors PAIP1 EIF2B4 EIF5B PABPC1;PABPC3 EIF2S1 EIF2B3 CLUH EIF2B2 EIF4A2 EIF5A;EIF5AL1 EIF4A1 EEF1G EIF4G1 EEF1A1 EEF1D EEF1A2 EIF4G3 ETF1 EEF2 EIF4B EIF2AK1 EEF2K EIF2AK3 EIF6 EIF2AK2 EIF4E EIF2S2 EIF2S3;EIF2S3B EIF1 EIF3C;EIF3CL EIF5 EIF1AY;EIF1AX EIF2B5 EIF3I EIF3J EIF3G EIF3H GSPT2 EIF4EBP1 EIF3E EIF4H EIF3F EIF4EBP2 EIF3D EIF2B1 EIF3A EEF1B2-1 EIF3B ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260211%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma AKT2 AKT3 AKT1 MTOR 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260211%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression EIF4E MKNK1 MAP2K3 MAP2K2;MAP2K1 RAF1 PIK3CD PIK3R2 PIK3R1 MTOR MAP3K11 PIK3CB PBK MAPK1 AKT1 PIK3R3 PIK3CA MAPK3 EIF4EBP1 TSC2 MAP2K6 PRKAA1 TSC1 MKNK2 MAP3K5 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260211%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 FBXO32 PAX7 MYOD1 RET VEGFA DUX4;DUXA MYF5 CDKN1A PPARGC1A MYC UPF1 MYOG ADRB2 ESR2 TRIM63 EP300 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2853%HOMO SAPIENS Endoderm differentiation HHEX TRIM5 ZIC3 TGFB1 JARID2 DUSP5 DUSP2 NOG PARP8 NME1 TOX3 DDAH1 AEBP2 SMAD2;SMAD3 MTF2 HOXA1 PAX9 AHDC1 BTAF1 LEO1 ASCC3 GATA4 ZNF462 CTBP2 KDM4A NOTCH1 ELP4 GRHL2 LRPPRC TNRC6C BMP7 TAF5 LHX1 MIXL1 SFRP1 PAX3 MAP2K3 CRTC1 LEF1 TCF7 FOXA1 ACACA TCF4 TCF7L1 APP FOXA2 TET1 SIAH2 DKK1 EZH2 GATA6 PLCH1 FOXH1 SOX7 ZBTB17 FOXO1-1 NABP2 POU5F1;POU5F1B CAND1 GLI2 PIAS1 MAD2L2 NAA15 WNT8A CTNNB1 LAMC1 SOX2 SLC2A12 C1QBP SMAD4 PTHLH BMPR1A NR3C1 SESN1 WNT3 PABPC1;PABPC3 TBX21 OTX2 ELAVL1 STAT1 WWC1 SOX21 SOX17 CEP250 DIP2A CER1 EOMES WDHD1 DNMT3B SFMBT1 CEBPZ ELK4 ZNF281 CDYL EMSY RFX7 RAB38 WDFY2 HPRT1 BCORL1 TOX DUSP4 CTR9 PRDM14 RTF1 NLK MBTD1 EPB41L5 UBR5 BPTF ATP8B2 PBX3 APC HNF1B FOXN3 GDF3 ZFHX4 TRERF1 PBX1 VAV3 EXT1 NKX2-1 DAB2 NANOG;NANOGP8 SP4 TAF4B PAF1 NODAL RGS10 TRIM71 RARG ONECUT1 NCAPG2 HOXC11 CUL4B PHF6 CDC73 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor pathway GCLC NRAS AIP MAP2K2;MAP2K1 NFE2L2 EGFR PTGS2-2 E2F1 RET FGF21 VEGFA CDKN1A MYC ARNT TNF MAPK1 CDC37 HPGDS PLAGL1 CD36 KLF6 PSRC1 ESR1 NCOA7 AHRR CDK2 NRIP1 KRAS NF1 RAF1 NFKB1 LPL NQO1 HSP90AA1 RB1 HRAS CYP1A1 NCOR2 AHR SRC CYP1A2 CYP1B1 CDKN1B RELA EP300 CCL1 GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260211%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells GLP1R SLC2A1 SLC2A2 INS;INS-IGF2 IL6R IL6 GCG LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260211%WP3935%HOMO SAPIENS Leptin insulin signaling overlap STAT3 DGKZ PIK3CG JAK2 LEP PDPK1 INS;INS-IGF2 LEPR IRS1 IRS4 IRS2 SOCS2 SOCS3 SOCS1 AKT1 PIK3R3 INSR SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260211%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms AGTR1 REN TMPRSS2 AGT ACE2 MAS1 ACE DRAVET SYNDROME%WIKIPATHWAYS_20260211%WP5200%HOMO SAPIENS Dravet syndrome PRKCA MLST8 TNF AKT1 PIK3CA FGF13 STXBP1 CAMK2A PRR5 MAPKAP1 KCNA2 PRR5L PCDH19 CHD2 SCN3B NFKB1 SCN3A MAPK11 SCN1B SCN1A MTOR SNTA1 SCN2A SCN4B SCN2B HCN1 SCN8A CALM1 RICTOR S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260211%WP26%HOMO SAPIENS S1P receptor signal transduction PIK3C2B ASAH1 MAPK6 MAPK4 PLCB3 AKT2 SPHK2 AKT3 SPHK1 MAPK1 AKT1 MAPK3 GNAI1 MAPK7 S1PR1 S1PR3 MAPK12 SMPD2 RACGAP1 S1PR2 GNAI3 S1PR5 GNAI2 PLCB1 PLCB2 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260211%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome SGK1-1 MYT1 SIN3A OPRK1 CSRP1 NCOR1 GRIN1 MEF2C GRIA1 DLX5 CTCF CNP MBP FUS BDNF NF1 UBE3A SP1 GRIA3 MAG GRIA4 PTEN PSIP1 YBX1 GABRR2 CDON REST GAMT TET1 RBFOX1 TET2 TAP1 POU3F2 HNRNPH1 GPRIN1 TET3 EZH2 ARHGEF26 FOXG1 DLX6 NREP CEBPD FUT8 MPP1 PRPF38A FKBP5 GAD1 IGF2 E2F1 POU4F1 SST HDAC1 HNRNPF TAF1 BCL6 IGF1R TARDBP CREB1 SMC3 AKT1 APOC2 RPS6 IGF1 CAMK2A SP3 MTOR FGF3 FGF4 GRID1 FGF5 DHX9 FGF2 MECP2 CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway DHCR7 SQLE IDI1 FDPS MVK HMGCR MSMO1 LSS HMGCS1-1 PMVK MVD FDFT1 NSDHL CYP51A1 SC5D MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260211%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors ITGB5 THBS2 FN1 LAMB2 ITGB6 TNXB COL1A2 LAMC1 SDC2 COL3A1 COL5A1 COL6A2 ITGA1 THBS1 COL5A3 COL6A1 COL6A3 ITGA11 COL5A2 LAMA4 COL4A2 COL4A1 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260211%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling CD80 PFKFB4 GSK3B IL12A MTOR PRKAA2 IL10 HLA-DRA RXRA LDHA MYC CYP24A1 VDR HK3 AKT1 PIK3CA PDHA1 TSC2 TSC1 CD86 RELA NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260211%WP4747%HOMO SAPIENS Netrin UNC5B signaling PTK2 PRKCA MAP2K2;MAP2K1 COL1A1 KDR CCN2 TNF ALPL CCL13;CCL2 PPP1CA ITGB4 RAF1 JUN RAC1 PTPA NEO1 SELE IL10 CASP3 MYF5 PPP2R1B MAPK1 AKT1 ROBO4 PIK3CA MAPK3 CDH5 RHOA ARHGEF12 YAP1-1 UNC5B CIP2A RGMA DCSTAMP MAPK14 DAPK1-1 NTN4 INPP5D NTN1 VCAM1 RLF PTK2B NTN3 PLEKHH1 ICAM1 TP53 IL1A SRC AGAP2 FYN PTPN11 HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260211%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis HIPK2 SIAH1 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260211%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex PRG3 LCK CD2 CD4 IGLL5;IGLL1 NKRF IL6 CD8A CD8B;CD8B2 LBP CD3G HLA-DRA CD247 CD3E ZAP70 CXCL8 MMP25 FYN CRP HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 FANCONI ANEMIA%WIKIPATHWAYS_20260211%WP5465%HOMO SAPIENS Fanconi anemia RFWD3-2 PALB2 FANCG NBN FANCF CEBPD RAD51C ERCC4 EGFR ERCC1 MAD2L2 MCM2 HSP90B1 FANCI RAD50 RAD51 UBE2T USP1 SMARCA4 UHRF1 ATM ATR DCLRE1B MRE11 CTDP1 UHRF2 CENPS-CORT;CORT;CENPS FAAP24 PTEN BRIP1 BRCA1 LOC105377022;FANCB BRCA2 SLX4 MEN1 FANCD2 FAAP100 FANCM CENPX FAN1 FANCL XRCC2 FANCA REV1 FANCC FANCE EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260211%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling NFKBIA PDLIM7 MAP3K3 NFKB2 IKBKG NFKB1 CCL5 IKBKB HSP90AA1 MAPK8 CCL20 CHUK TRADD TRAF1 MAP3K14 IFNB1-4 MAP3K7 CXCL8 TNF MAPK1 TRAF6 IRAK1 RELA RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260211%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 NPAS2 SMAD4 PCNA DDX21 FBL IRF2 POLR1E ALX1 CLOCK CREBBP CREB1 ARNTL MAFG NCOA3 FOXO1-1 P38 MAPK SIGNALING%WIKIPATHWAYS_20260211%WP400%HOMO SAPIENS p38 MAPK signaling DDIT3 TGFB2 SHC1-1 MAX STAT1 RASGRF1 MAPKAPK2 HMGN1 GRB2 MAPKAPK5 TGFBR1-1 HSPB1 TRAF2 CREB1 MYC MEF2D MAP3K1 ELK1 MAP2K6 DAXX MAP3K5 MAPK14 MAP3K9 MKNK1 MAP2K4 SMIM40 ATF2 HRAS CDC42 RPS6KA5 TRADD PLA2G4A MAP3K7 RAC1 RIPK1 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP357%HOMO SAPIENS Fatty acid biosynthesis ACSL1 ACSL6 ACSL5 ACLY ACSL4 ACSL3 ECHS1 PC ACAA2 ACACA PECR MECR FASN ACSS2 ECH1 ECHDC1 ECHDC2 ECHDC3 DECR1 HADH ACACB SCD COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260211%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway C5AR1 COLEC11 C9 C8A MASP2 C3AR1 C3-1 C5 ACE2 FCN2;FCN1 C6 C7 ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies IL25 STAT3 IL2RG JAK3 TYK2 OSMR IL1RL1 STAT6 IL13RA1 TSLP IL33 IL4R CRLF2 IL13 IL4 IL5 FCER1G IL31RA FCER1A DEFB103A;DEFB103B MS4A2 METHYLATION PATHWAYS%WIKIPATHWAYS_20260211%WP704%HOMO SAPIENS Methylation pathways HNMT MAT2B MAT2A MAT1A PNMT COMT NNMT TPMT INMT METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer UAP1 PDHB GLUD1;GLUD2 CS BCKDHA GOT1-1 GFPT1 SLC2A1 RPIA RPE;RPEL1 BCAT2 HMGCS2 ME1 PFKL SLC7A5 GPI GLS2 HK2 SLC43A1 PKM PGM3 DLAT SOAT1 SLC16A4 ACLY KRAS SLC16A1 CARM1 GNPNAT1 DLD GOT2-1 HMGCR PDHX SLC1A5 FASN TP53 GPT LDHA HK1 LDLR PDHA1 MDH1 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260211%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA RPE;RPEL1 TALDO1 PGD PGLS G6PD TKT LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260211%WP3965%HOMO SAPIENS Lipid metabolism pathway PNPLA2 PRKACA-1 PRKAG1 PRKAG2 BCKDHA PRKAR1B PRKAA2 PRKAR1A PRKAG3 LIPE ACSS2 AKT2 PRKAB2 AKT3 AKT1 PRKAB1 PRKAA1 PRKAR2B PRKAR2A ACLY ABHD5 PRKACB-1 ACSBG1 ACACA FASN PLIN1 PDHA1 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260211%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation PCSK9 LDLR INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment IRAK4 CD80 TGFB2 TGFB1 TGFB3 IL2RG STAT3 NFKB2 STAT6 IL4R TLR8 CD274 IL4 CTLA4 TLR7 CXCL10 PDCD1 TRAF6 CCL13;CCL2 TLR4 CCL5 NFKB1 IL2RA IL2RB PIAS3 SOCS1 CD86 TGFBR2 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260211%WP5572%HOMO SAPIENS Nucleosome remodeling complex XRCC6 SMIM40 PCNA MCM2 NASP-1 CHAF1A SUPT16H H4-16 XRCC5 SSRP1 IPO4 CHAF1B HAT1 ASF1A ASF1B NAP1L1 RBBP4 CHEK2 PRKDC H4C1 H4C6 DAXX CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260211%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism CYP2A13;CYP2A6;CYP2A7-1 CYP1A2 XDH HEPATITIS B INFECTION%WIKIPATHWAYS_20260211%WP4666%HOMO SAPIENS Hepatitis B infection TGFB2 TGFB1 TGFB3 STAT3 MAPK10 MAPK9 MAPK8 SMAD2;SMAD3 GRB2 SOS1 CASP8 MAP3K1 STAT2 PIK3R3 ELK1 STAT5A STAT5B MAP2K3 MAP2K4 MAPK12 TYK2 MAPK13 MAPK11 CREBBP ARAF TICAM1 IKBKE EP300 VDAC3 EGR2 TBK1 IKBKG DDX58 PIK3R2 PIK3R1 IFIH1 IRF3 TGFBR1-1 TLR3 FADD MAVS CREB3L3 AKT2 CDKN1A MYC IFNB1-4 CREB3L4 AKT3 CREB3L1 MAPK1 AKT1 TRAF3 MAPK3 TRAF6 BRAF TLR4 BAX KRAS ATF2 CREB3L2 IKBKB JAK2 HRAS SRC PRKCG RELA PRKCB CYCS-1 IFNAR1 NRAS PRKCA MAP2K2;MAP2K1 BID FAS ATF4 SOS2 TNF MMP9 IRF7 SMAD4 RAF1 JUN NFKB1 TAB1 TLR2 IL6 BIRC5 TICAM2 HSPG2 CASP10 FASLG ATP6AP1 TIRAP JAK1 DDB1 DDX3X-1 CREB5 IRAK1 MAP2K7 TGFBR2 YWHAB IRAK4 BCL2 TAB2 MYD88 DDB2 YWHAQ STAT4 PIK3CD STAT6 PIK3CB STAT1 CASP9 FOS CASP3 YWHAZ CHUK CREB3 NFATC1 APAF1 CREB1 CXCL8 PIK3CA MAP2K6 ATF6B NFATC3 MAPK14 NFATC2 NFATC4 PTK2B JAK3 PCNA BAD SLC10A1 MAP3K7 EGR3 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260211%WP4758%HOMO SAPIENS Nephrotic syndrome PODXL COQ2 TTC21B COL4A4 PDSS2 GPC5 SYNPO ARHGDIA PMM2 EMP2 WDR73 LAMB2 ALG1 COQ6 ARHGAP24 PAX2 CD2AP ANLN APOL3;APOL4;APOL1;APOL2 INF2 NPHS1 CYP11B1;CYP11B2 NPHS2 LMX1B WT1 COL4A3 COL4A5 CTLA4 PLCE1 TRPC6 ITGB4 ZMPSTE24 LMNA ITGA3 MYH9 E2F3 CUBN ACTN4 MYO1E SCARB2 SMARCAL1 CD151 PTPRO YARS1 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260211%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 SUZ12 JARID2 AEBP2 MTF2 EED MORC3 ELL RBBP4 BCLAF1 STK38 THRAP3 TRIM35 RBBP7 EZH1 SETX EZH2 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260211%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation F13A1 FGB FGA F13B FGG F2 PLG BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260211%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY AKT1 MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260211%WP5236%HOMO SAPIENS Markers of kidney cell lineage ACTA2 KDR PDGFRB NOTCH2 NOTCH1 WT1 RSPO1 HNF1A SMAD1 BMP7 LHX1 SMAD5 BMP4 SFRP1 DCN WNT5A DES REN TNC AP2B1 NT5E WNT4 PAX2 NPHS1 HNF4A NPHS2 AXIN2 CITED1 TCF21 SALL1 SIX2 RSPO3 SIX1 DACT1 EMX2 FOXD1 OSR1 NTN1 KCTD1 ALDH1A2 PECAM1 TSHZ3 EGLN1 EGLN3 KIT EGLN2 EYA1 TBX18 HNF1B GDNF TLX1 FAT4 VSX2 PBX1 FGF7 FGF8 EPO JAG1 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP5414%HOMO SAPIENS IDO metabolic pathway IDO2 IDO1 TDO2 KYAT3 KYAT1 AADAT TNF GOT2-1 IFNG KMO KYNU LIDOCAINE METABOLISM%WIKIPATHWAYS_20260211%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260211%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 STAT5A EGF FOSL1 NRIP1 FN1 PGR VIM TIMP1 CCND1 AREG MYC ERBB2 ESR1 HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260211%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 ZYG11B CBFB CUL2 UBA3 ELOB ELOC-1 NAE1 RBX1 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260211%WP5598%HOMO SAPIENS Sodium channel in epilepsy NFASC SCN4A RNF121 GSK3B RACK1 NEDD4 WEE1 FGF14 TNF AKT1 FGF13 FGF12 SCN9A CAMK2A SCN3B JAK2 SCN3A SCN1B SCN1A SCN10A SCN2A PSEN1 SCN4B SCN2B BACE1 SCN8A PTPRN NEDD4L CALM1 SCNM1;TNFAIP8L2-SCNM1 PDCD10 SCN11A SCN7A FYN SCN5A PRRT2 MAPK8IP2 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260211%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260211%WP1772%HOMO SAPIENS Apoptosis modulation and signaling CYCS-1 NFKBIA HRK CASP7 CAPNS1 PEA15 CASP2 DFFB DFFA SEPTIN4-1 PTRH2 MADD HTRA2 MAPK8 BID TNFRSF25 NAIP BCL2A1 PRKD1 XIAP HSPA1A;HSPA1B BCL2L10 BAG3 FAS BMF CRADD BIK BNIP3 PTPN13 BCL2L2 CASP8 BCL2L11 CDKN2A CASP1 MAP3K5 JUN NFKB1 BIRC5 TRADD CASP10 ENDOG FASLG CASP5;CASP4 DIABLO-1 CFLAR CASP6 RIPK1 BBC3 IRAK1 PIDD1 AIFM1 IL1R1 TOLLIP BCL2 MYD88 TNFSF10 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BAK1 MCL1 BOK CASP9 PMAIP1 FOS CASP3 FADD APAF1 MAP3K14 BLK IL1R2 TNFRSF1A TRAF3 BIRC7 MAPK3 AIFM2 TRAF6 DAXX BIRC2 BIRC3 BAX SMIM40 BCL2L1 IKBKB BAD TNFRSF1B TP53 NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP268%HOMO SAPIENS Notch signaling HDAC1 DLL1 APH1A DLL3 NCSTN DLL4 APH1B NOTCH2 NOTCH3 CTBP2 NOTCH1 NOTCH4 RBPJL CTBP1 DTX2 RFNG DTX3 DTX4 LFNG INPP5K PTCRA KCNJ5 DTX3L KAT2A ADAM17 MFNG KAT2B PSEN2 MAML1 RBPJ PSEN1 HES1 HES5 NCOR2 NUMB MAML3 NUMBL CREBBP DTX1 HDAC2 DVL1 DVL2 DVL3 JAG2 JAG1 METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260211%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS2 FADS1 PTGS2-2 ALOX12 ALOX15 ALOX5 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260211%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb MAP2K2;MAP2K1 UQCRB UQCR11 UQCR10 UQCRQ UQCRC1 UQCRFS1 CYC1 UQCRC2 NDUFV1 COX7C RAB5IF MAPK12 NDUFS8 MAPK13 NDUFS3 CDH18 MAPK11 COX5A TRPM7 PDZD9 CDR2 NDUFA9 TRAP1 NDUFA4 SDR42E2 VWA3A MOSMO-1 POLR3E CALM1 CALM2 PRKAG1 PRKAG2 PRKAA2 PRKAG3 RPTOR MLST8 EEF2 PRKAB2 CDK1 MAPK1 PRKAB1 EEF2K MAPK3 PRKAA1 MAPK14 RPS6KB1 CDK2 RPS6KA1 MTOR CALM3;CALM1 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260211%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling MAPK14 GRK6 SGK1-1 FSHB RPS6KB1 RPS6KB2 RHEB PRKCA RAF1 PRKACA-1 MTOR CGA FSHR SRC CREB1 APPL1 MAPK1 AKT1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MAPK3 EIF4EBP1 RPS6 TSC2 FOXO1-1 PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling REL RELB NFKB2 PTGS2-2 CSF2 SELE CD40LG BCL2A1 VEGFA CHUK IL2 IL1B BCL2L2 CXCL8 TNF CXCL2;CXCL3;CXCL1-1 MMP9 TNFRSF1A TRAF6 BIRC2 BIRC3 VCAM1 MMP2 MMP3 NFKB1 IKBKB EGLN2 IL6 BIRC5 ICAM1 IL1A CCND1 CFLAR MMP1 RELA EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260211%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway EPHX2 PPARA PPARG CYP2C18-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260211%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists PPARA NPC1L1 SCARB1 NR1I2 VDR CYP2C9;CYP2C19 CD36 PPARD COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260211%WP2636%HOMO SAPIENS Common pathways underlying drug addiction PRKCB DRD1 DRD2 MAP2K2;MAP2K1 PRKCA DRD4 PRKACA-1 GNAS-1 GRIN2A GRIN1 RAP1B PPP1R1A RAP1A GRIA1 CREB1 GJB1 MAPK1 MAPK3 GNAI1 CAMK2A PPP1CA ADCY1 ADCY8 RAF1 PRKACB-1 GRIA2 PPP1CB PPP1CC GRIA3 GRIA4 ACTB-1 ACTG1 GRM5 ARAF CAMK4 CALM1 GRM1 PRKCG ACTC1;ACTG2 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis CYP11B1;CYP11B2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HSD11B1 HSD11B2 SRD5A2 CYP21A2 SRD5A1 AKR1D1 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260211%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia TRPC3 HOMER3 CA8 CACNA1A GNA11 RYR3 GRIA2 GNAQ GRIA3 GRIA4 PLCB3 GRIA1 ITPR1 PLCB4 GRM1 PRKCG PLCB1 PLCB2 ATP2B2 GNA15 PDK1 GNA14 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260211%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy MYEF2 TGFB1 AKT2 STAT3 NFKB1 AKT1 RASGRF1 PPP3R1 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260211%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling NFKBIA RELB CASP7 NFKBIB NFKB2 GSK3B MAPK9 HDAC1 MAPK8 CASP3 FADD CHUK TRAF1 CTNNB1 MAP3K14 TRAF2 AKT2 TRAF5 TNF CASP8 MAPK1 AKT1 TRAF3 MAPK3 BIRC2 MAPK14 BIRC3 JUN RAF1 NFKB1 IKBKB MAP3K7 RAC1 RIPK1 RELA TRIM63 TNFRSF12A AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260211%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy NFKBIA TGFB1 SMAD2;SMAD3 CCN2 AGTR1 ITPR1 ITPR2 ITPR3 TNF MMP9 TRPC6 TRPC3 SMAD4 CYBB MMP2 PPIF PLAU NFKB1 GLI1 IL6 CACNB1 CACNA1F PLA2G4A HSPA9 RYR1 CACNA1S TGFBR2 SPP1 MCUB SCX ELANE TOMM20 ORAI1 PLA2G2A-1 VDAC1 SGCA MCU CAPN3 TRPC1 TRDN ATP2A1 CACNB2 STIM1 PRKAA2 CASP9 CASQ1 IL10 TNNI1 SARAF TGFBR1-1 DMD CACNG1 DTNA GP2 FKBP1A IL1B SSPN SNTB1 CAMK2D SLC25A5 SIGMAR1 PRKAA1 NOX4 PRG3 NOS2 SERPINE1 CACNA2D1 MPO FGB IL1A FGA FGG DAG1 CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260211%WP2023%HOMO SAPIENS Cell differentiation expanded index PAX7 RUNX2 ID2-1 STAT3 MYOD1 TLX1 MEF2A MEF2C SOX2 SRF LEFTY2;LEFTY1 TLX2 KLF4 TLX3 HDAC5 MEF2D MEF2B;BORCS8-MEF2B EZH2 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260211%WP3972%HOMO SAPIENS PDGFR beta pathway PRKCB MAP2K2;MAP2K1 STAT3 PRKCA SHC1-1 PIK3R1 MAPK8 STAT6 PDGFRB STAT1 GRB2 FOS SOS1 SRF MAP3K1 RASA1 MAPK3 PIK3CA ELK1 EIF2AK2 STAT5A STAT5B PLCG1 MAP2K4 JUN RAF1 JAK2 HRAS JAK1 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260211%WP4150%HOMO SAPIENS Wnt signaling in kidney disease WNT3 WNT4 WNT3A WNT9B MAPK10 WNT2B MAPK9 MAPK8 WNT7B WNT7A CTNNB1 FZD1 WNT10B WNT10A FZD3 WNT16 INVS FZD2 NPHP3 FZD5 FZD7 RHOA FZD6 FZD9 WNT5B FZD8 WNT5A LRP5 LRP6 WNT11 WNT6 DVL1 DVL2 DVL3 FZD4 WNT1 WNT2 MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260211%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 ARCN1 ID2-1 CDKN1A ID1 USP1 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260211%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia GSK3B CSNK1A1 PML CTNNB1 MYC AXIN2 AKT1 FLT3 WIF1 FZD6 RUNX1T1 ZBTB16 PYGO1 BCL9 RARA LRP5 LRP6 SALL4 LEF1 JUP APC CCND1 DKK1 PPARD WNT1 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260211%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins CTH SELENOK NFE2L2 FOS GPX1 GPX4 RPL30 SP3 SELENOI SELENBP1 SEPHS1 SEPHS2 JUN PSTK TXNRD3 EEFSEC NFKB1 POU2F1 SECISBP2 GPX6 TXNRD2 TRNAU1AP SP1 SELENOO SELENON SEPSECS SARS1 SARS2 DIO1 SELENOS DIO3 SELENOP FABP1 SELENOT SCLY CREM RELA TXNRD1 HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260211%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias CPOX ALAD ALAS2 FECH UROD UROS HMBS PPOX ALAS1 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5366%HOMO SAPIENS NF1 copy number variation syndrome EXOC8 EXOC7 ADAP2 SUZ12 RFC2 MYT1 JARID2 POLRMT EXOC4 EXOC3 EXOC6 EVL EXOC5 ATAD5-1 EXOC2 EXOC1 RNF135 HOXA1 INPP5A E2F6 SOS1 RAB11FIP4 TEFM UTP6 ARF6 RAB11A COPRS EVI2A CRLF3 EVI2B METAP2 SYN1 MAP3K2 MAP3K1 USP1 EGF PER1 RAF1 NF1 CCNE1 OMG ATR NGF DNMT1 BCL2 EGFR CFL1 CCNE2 TUBB4A;TUBB;TUBB8B;TUBB8 DDX58 MCL1 RFC3 RTN4R RFC4 MAVS NGFR RAD51 CCNA2-1 SDC2 IFNB1-4 MAPK1 RAD9A RBBP7 CRY1 MAPK3 EZH1 RHOA ROCK2 SUPT5H PCNA LIMK1 H4-16 EED H4C1 PRMT5 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H4C6 WDR48 HOXA9 EIF3A RFC5 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260211%WP3934%HOMO SAPIENS Leptin and adiponectin ADIPOR2 LEPR PRKAG1 PRKAB1 CPT1A LEP PRKAA1 ADIPOQ ADIPOR1 ACACA GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260211%WP2361%HOMO SAPIENS Gastric cancer network 1 H3-3A TOP2A AURKA UBE2C NOTCH1 INO80D NUP107 KIF15 ACTL6A ESM1 CCNA1 RNF216 RUVBL1 MYBL2 ECT2 E2F7 TPX2 SMOC2 CENPF MCM4 GATD3B;GATD3A KIF20B S100P APC H4-16 CEP192 LIN9 VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260211%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins PROC F10 VKORC1 VKORC1L1 UBIAD1 F2 NQO1 F7 GGCX AIFM2 F9 PROS1 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5406%HOMO SAPIENS 13q12 12 copy number variation SGCA MAPK9 MAPK8 RTN4R DMD DTNA TRAF1 TRAF2 TRAF5 SSPN SNTB1 TRAF3 RHOA ADIPOQ LINGO1 C1QTNF9B;C1QTNF9 SGCD SNTA1 ATXN1 CDC42 SGCB FLNC MAG SGCG TNFRSF19 RTN4 SPATA13 MIPEP RAC1 DAG1 SACS TNF ALPHA SIGNALING%WIKIPATHWAYS_20260211%WP231%HOMO SAPIENS TNF alpha signaling NFKBIA NRAS CASP7 NFKBIB NFKB2 MAPK9 MADD MAPK8 BID MAP4K2 GRB2 TNFAIP3 SOS1 TNF CASP8 PRKCZ GLUL MAP3K1 PLK1 PSMD2 MAP3K5 MAP2K3 MAP2K4 RAF1 JUN NFKB1 TAB1 HSP90AA1 TRAP1 CUL1 SMPD2 TRADD FBXW11 OTUD7B CREBBP PYGL RFK TXN KSR2 PTPRCAP RAC1 NSMAF DIABLO-1 NOXO1 CFLAR RIPK3 NFKBIE RIPK1 TANK MAP2K7 RFFL REL TAB3 TAB2 TBK1 IKBKG BTRC SKP1 CASP9 CASP3 CHUK FADD APAF1 TRAF1 MAP3K14 TRAF2 KSR1 MAPK1 AKT1 TNFRSF1A CDC37 CYBA MAPK3 MAP2K6 BIRC2 BIRC3 BAX PPP2CB;PPP2CA MAP3K3 KRAS NOX1 BCL2L1 IKBKB BAD HRAS TNFRSF1B MAP3K8 MAP3K7 CSNK2A1;CSNK2A3 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence DPEP2 DPEP1 PTGS2-2 ELOVL5 SIRT1 CDKN1A DECR1 HPGDS ABCC4 ALOX12 LTC4S CYSLTR1 ALOX5 GPX1 LTA4H PTGES3-1 ALOX15B ALOX5AP GSTP1 ALDH1A1 HPGD MAPK11 SERPINE1 AKR1B1 ALOX15 RB1 PTGS1 EPHX2 FADS2 PTGDS TP53 PTGIS GGT1 FADS1 PLA2G4A CBR1-1 PTGR2 PRXL2B ALOXE3 TBXAS1 GGT5 PTGES2 ELOVL2 PTGES SLCO2A1 PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260211%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway NT5E NTF4 WNT3A TGFB1 FST TGFB3 FLT3LG INHBA CSF1R NOG GDF5 WNT2B IL11 IL6R WNT7B PDGFA HGF VEGFA INS;INS-IGF2 NOTCH1 CSF1 ALK LEFTY2;LEFTY1 PDGFB BMP4 SHH IGF1 CNTF CXCR1 FGF10 EGF WNT5A IL3 TNFSF11 KIT IL6 TF FGF1 FGF4 FGF8 TPO KITLG NODAL EPO FGF2 DKK1 WNT1 WNT2 FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260211%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling CD14 IRAK4 REL MYD88 IKBKG LY96 IL12B RASSF5 IRF3 TLR3 CHUK IFNB1-4 TNF FCER1G CXCL2;CXCL3;CXCL1-1 AKT1 CXCL10 PIK3CA RHOA TRAF6 ITGAM SYK CCL13;CCL2 ITGB2 TLR4 NOS2 NFKB1 IKBKB IL6 PLAT LBP CBLB FGB TYROBP SRC TICAM2 FGA FGG TIRAP PLG TICAM1 IRAK1 RELA IRAK2 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260211%WP5173%HOMO SAPIENS Disorders of galactose metabolism SLC5A1-1 GALT GBE1 AKR1B1 GALE GYG2 GALK1 GYS2 GYS1 SLC2A2 PYGL GYG1 PGM1 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260211%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer CYCS-1 RALA-1 TGFB2 TGFB1 TGFB3 MAP2K2;MAP2K1 MSH6 MAPK10 MSH2 EXOC2 MAPK9 MAPK8 SMAD2;SMAD3 CSNK1A1 CTNNB1 GADD45A BCL2L11 SMAD4 RAF1 JUN LEF1 TCF7 BIRC5 TCF7L2 TCF7L1 ARAF APPL1 RAC1 BBC3 TGFBR2 RAC3 BCL2 REL TBK1 DDB2 GSK3B PTGS2-2 BAK1 CASP9 DCC PMAIP1 FOS MSH3 TGFBR1-1 CASP3 GADD45B MLH1 GADD45G AXIN1 CDKN1A AKT2 MYC AKT3 AXIN2 POLK MAPK1 AKT1 MAPK3 RHOA BRAF BAX NTN1 KRAS RALGDS BAD APC APC2 TP53 CCND1 RALB PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260211%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function PDE3B PDE4A GUCY1A2 ADCY9 GRIN1 GRIA1 PDE3A PDE4D-1 DRD1 DRD2 PRKACA-1 PDE4B NOS1 GRIN2A GUCY1B1 PDE8B PDE8A PRKG1 CREB1 PDE4C PPP1R1B PDE12 ADORA2A PDE5A PDE9A PDE1C PDE1B PDE1A PDE11A PDE6D PDE6C PDE6B PDE6A CAMK2A PDE6H GRIN2C ADCY4 PDE2A GRIN2B ADCY3 CHRNA7;CHRFAM7A GRIN2D ADCY10 ADCY2 PDE10A ADCY1 PDE7B ADCY8 PDE7A ADCY7 ADCY6 ADCY5 GUCY1A1 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260211%WP1422%HOMO SAPIENS Sphingolipid pathway ASAH1 CERK SGMS1 GBA SGMS2 GBA2 UGT8 UGCG SGPL1 SPTLC1 KDSR CERS3 CERS4 CERS6 SPHK2 SPHK1 SGPP2 PLPP1 CERS2 PPP1CA ASAH2 PPP2CB;PPP2CA GAL3ST1 SPTLC3 CERT1 CERS5 ACER1 SERINC1 B4GALT6 VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260211%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling BCAR1 SOD2 STAT3 FN1 ALB MAPK9 MAPK8 TNFRSF25 CCN2 HSPA1A;HSPA1B TUBA1C PSMD4 INPP5K MMP2 MMP10 MMP14 PSMD11 IDH2 OCRL SIAH2 GLUD1;GLUD2 TUBB4A;TUBB;TUBB8B;TUBB8 TRPC1 FLT1 EPRS1 P4HA2 FARSB MAPK1 AKT1 MAPK3 EPHA2 FOXO1-1 PGF ITGB1 PPP2CB;PPP2CA ATF2 TNXB SLC8A1 SARS1 VAV2 ACTG1 GJA1 SRC FYN PTPN1 PTPN11 PRKCB PRDX6 PTK2 IGFBP3 NFKBIA PRKCE PRKCD PTPN6 PRKCA SHC1-1 CALR-1 MYL2 ITGB3 PRKD1 ATF4 RAB11A PRKCZ PLAUR ITGB5 PLCG1 HBEGF JUN NFKB1 ITGAV HSP90AA1 TXN ACKR3-2 YWHAE PGD ARRB2 SELE SET-1 PLCB3 PRKG1 CREB1 HDAC4 ATP6V1E1 HDAC5 HDAC9 HDAC7 NFATC2 WASF1-1 ARPC5L RPL7 LUC7L NUMB RPS6KA5 IER5 GRB10 ACOT9 NOS3 SND1 EWSR1 BIN1 TXNIP RPL27 PRKD2 RPL26 FLII GIGYF2 MYO6 PRRC2C TRIP4 LARP7 RAB4A RPL5-1 GIPC1 HYOU1 KCNC3 SRP54 SHB EEA1 CSRP2 RACK1 RPLP2 CGNL1 SSR4 SSR3 TAL1 ENG ADAM10 KANK1 RHOJ SLC7A1 APOLD1 ARF6 FGD5 FLNB BRD4 TAOK2 NOTCH4 CTNND1 PXN PLOD3 RPL10A TMSB10 SEMA6D ARMCX1 RAB37 FSCN1 MYO1C ADAM9 DSC1 PAK2 LRRC59 TRPC3 STIP1 IGFBP7 TXNDC5 SDF2L1 BMX QKI RCAN1 TFCP2 PLAU RCAN2 SPIRE1 F3 EIF4G2 FHL2 NRARP CAPZB ADAMTS1 ACP1 ADAMTS9 RPL13A-1 LMAN1 SLC25A11 PBXIP1 NAP1L1 PPM1G RHOC DNAJB4 BMP2 DNAJB9 SLC25A25 CDC42BPB PTPN14 CTNNA1 TPCN2 DKK1 PTPN9 P4HB RPL18A BSG UBAP2L CHAC1 EPHB2 RPS11 EIF2A TMEM170A INPP4B ATF6 BMP10 KATNAL2 ZNF555;ZNF57;ZNF556 PTGS2-2 PFN1 EZR PIK3R2 ATP6V0D1 PIK3R1 DHX36 MICAL2 SMARCA2 SRPK1 CALU FADD DHX29 FAF1 TRAF3IP2 CCDC124 HERPUD1 CLIC1 ALDOA FJX1 NEXN CRIP2 GPC1 CCT7 PRKRA EIF2AK3 COPG1 FHOD1 NCF2 AMOT CCRL2 TMOD1 TMOD3 PDIA6 DPM1 NOX4 DOK1 VCL HTRA1 FUT1 SCUBE2 PPP3CA MYH11 ZC3H15 NR4A2 CACNA2D1 HRAS AFDN NRP2 NR4A3 GRSF1 C15orf39 LDB2 RND1 LRRFIP2 ARHGEF15 SHROOM2 ABCF2-H2BE1;ABCF2 RCN1 USP10 FAM120A RBM39 PDE4DIP FMNL3 RELA CYCS-1 MOV10 HLX MAP2K2;MAP2K1 KDR CSRP1 PDPK1 SH3BGRL3 FAS CTNNB1 ERG PRDX2 SHC2 CAPN2 MAP3K5 EIF4E CYBB ERN1 RAF1 DNAJA1-1 PLA2G5 BIRC5 MYH9 ARF4-1 PLA2G4A TPM3 MAP2K7 EIF4G1 GSK3B STAT6 GAPDH-1 NCF1 NCL-1 NFATC1 CXCL8 PIK3CA RAPGEF1 MTOR CDC42 TFAM-1 FOXO3 TEAD4 CBL GAB1 FRS2 CCN1 GRB2 FXR2 MEF2C SRF ELK1 CCL13;CCL2 PTPRJ MAP2K3 MAP2K4 MAPK12 ACACA PTMA CFL1 PRKCI MAPKAPK2 RAP1B RHOA CRK ROCK1 ROCK2 SDCBP MKNK1 TBCA LIMK1 MMRN2 PNP-1 JAG1 HMGB1-1 DLL4 PTPRZ1 CNP BCL2 PABPC1;PABPC3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A HDAC1 PBK HSPB1 NDRG1 NR4A1 OCLN-1 EGR1 TPP1 EGR3 DUSP5 CLTC AP2A1 ASCC3 NAPA PPP1CA MAPKAP1 AP2S1 FBXW11 CREBBP ETS1 ELOA GATA2 PRKAA2 MLST8 VPS39 ARNT CDH5 RPS6 PRKAA1 RPS6KB1 AKT1S1 CCND1 KL STAM MDM2-2 MAPKAPK5 RAP1A ABL1 DECR1 ADRB2 S1PR1 TKT PGK1 RAC1 ANXA1 EPB41 PAK1 STAT1 VEGFA MAP2K6 GPX1 HGS ACACB MAPK14 CAMKK2 FOXO4 IQGAP1 PTK2B RAB5A BCL2L1 CAV1 SYNJ1 ICAM1 NCK1 FGB EPN1 FGA LDHA ELOC-1 FGG CSK EIF3H RICTOR EIF3F EPS15 EIF3D HBD;HBB ITCH NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260211%WP5133%HOMO SAPIENS Non classical role of vitamin D AGTR1 REN CYP27B1 CYP2R1 AGT ACE2 ACE AGTR2 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP3996%HOMO SAPIENS Ethanol effects on histone modifications MTHFR AHCY DHFR2;DHFR HDAC10 HDAC1 ADH1C;ADH1B;ADH1A ACSS2 TYMS HDAC4 HDAC5 HDAC8 HDAC9 HDAC7 EHMT2 HDAC6 ALDH1A2 KAT2B ALDH1A1 ATF2 MTR-1 HAT1 CYP2E1 ELP3 HDAC2 MAT1A HDAC3 ALDH2 SLC19A1 ALDH1A3 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260211%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IRF9 IFNAR1 TBK1 TYK2 DDX58 IFIH1 STAT1 ACE2 IRF3 TLR3 MAVS IFNB1-4 STAT2 TRAF3 JAK1 IFNAR2 TICAM1 IKBKE INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260211%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide TLR4 MYD88 IFNB1-4 MAP1LC3A TLR9 TNF NFKB1 TRAF6 IFNG IRF3 BECN1 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260211%WP4823%HOMO SAPIENS Genes controlling nephrogenesis ROBO2 CXCR4 WNT4 HOXD11 GLI3 HOXA11 SLIT2 KIRREL1 MAGI2 ETV4 LAMB2 MAFB KDR PAX2 PDGFRB CD2AP RET VEGFA CXCL12 NPHS1 NOTCH2 NPHS2 CTNNB1 LMX1B WT1 FOXC2 FOXC1 LHX1 PDGFB TCF21 CD36 SHH SIX1 EMX2 FOXD1 ITGB1 FGFR2 EYA1 ITGA3 HNF1B GDNF NCK2 NCK1 FGF8 ITGA8 ILK INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260211%WP4558%HOMO SAPIENS Interferon mediated signaling IRF9 IFNAR1 PRKCA TYK2 IL10RB IFNK JAK2 IFNGR2 IFNLR1 PIK3R1 IFNL2;IFNL3;IFNL1 STAT1 IFNE IFNG IFNGR1 IFNB1-4 STAT2 JAK1 PIK3CA IFNAR2 IL6 SIGNALING%WIKIPATHWAYS_20260211%WP364%HOMO SAPIENS IL6 signaling PRKCD MAP2K2;MAP2K1 STAT3 SHC1-1 GAB1 GSK3B PIK3R2 IL6R HDAC1 PIK3R1 STAT1 AGT NCOA1 IRF1 GRB2 VIP SOS1 IL6ST MAPK1 AKT1 MAPK3 HCK CRP JUNB RPS6KB1 PRDM1 MAP2K4 NLK TYK2 BCL2L1 JAK2 BAD IL6 VAV1 TIMP1 CREBBP MAP3K7 SOCS3 RAC1 JAK1 NR2F6 PTPN11 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260211%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis GLP1R PCSK1 SLC2A1 INS;INS-IGF2 GCG PCSK2 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260211%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells FMO3 AOX1 CYP2B6 CYP2A13;CYP2A6;CYP2A7-1 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260211%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling FOXG1 TGIF2 FGF8 NKX2-1 TGIF1-1 GLI3 NODAL SMAD2;SMAD3 SHH HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260211%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation LATS2 TEAD1 TEAD2 TEAD3 CDH7 CCN2 FGFR3 FGFR4 PAK2 PPP1CA CDH18 PPP1CB PPP1CC NF2 BUB1B-PAK6;PAK6 SAV1 CTNNA1 PAK3 PAK5 PAK4 PPP1R14A PPP1R12A FLT1 RBX1 FOXM1 IGF1R NGFR MYC ITGA1 CDH5 INSR FLT3 EPHA2 YAP1-1 ITGAM AMOT ITGB2 ITGB1 KRAS NTRK1 NTRK2 ITGAX KIT HRAS CCND1 PLCB4 PTK2 FGFR1 NRAS CSF1R KDR PRKAR1B PDGFRB PRKAR1A PDGFRA ITGB3 ITGA2B CTNNB1 CDH9 CDH8 DCAF1 ITGA10 CDH4 MET CDH3 AJUBA ITGA11 CDH20 CXCL10 CDH22 CDH24 ITGA2 PRKAR2B WWTR1 LIN28B CDH10 PRKAR2A ITGB5 CDH11 CDH12 ITGB4 CDH13 FLT4 CDH15 CDH6 FGFR2 CDH17 CDH2 ITGAE VGLL4 CDH1 ITGAL CD44 CDH19 ITGB8 CUL4A ITGAV ITGB6 CDH16 ITGA3 ITGAD ITGA8 ITGA7 ITGA6 DDB1 ITGA5 ITGA9 EGFR PRKACA-1 PAK1 TEK MST1 PRKACB-1 ITGA4 ITGB7 TEAD4 STK3 LATS1 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis ACSL1 ACSL4 ACSL3 ACOT2;ACOT1 PLA2G5 PLA2G6 JMJD7-PLA2G4B;PLA2G4B ELOVL5 FADS2 PLA2G4A FADS1 ACOX1 ACOX3 ELOVL2 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome STAT3 AMER3 PLEKHB2 MZT2A;MZT2B APC STMN2 FAM168B CDC27 ARHGEF4 GPR148 CCDC42 RAC1 RHOA PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260211%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS PTK2 COL4A4 TGFB1 CDKN1C ITGB3 CTNNB1 NOTCH1 WT1 DNM1 TRPC6 PLAUR ITGB4 PLCG1 CDH2 ITGAV VIM LAMA5 ITGA3 MYH9 MKI67 KIRREL3 CTSV;CTSL KIRREL2 KRT8 UTRN ILK TLN1 VTN PARVA SCARB2 CDKN1B LIMS4;LIMS1 SMARCAL1 DKK1 FAT1 CD151 PTPRO WNT1 PODXL CD80 SYNPO YWHAQ LAMB2 CR1L;CR1 PAX2 CD2AP INF2 IRF6 NPHS1 NPHS2 LMX1B AGRN COL4A3 CDKN1A COL4A5 CAMK2B AKT1 PLCE1 CLDN1 TLR4 LRP5 ITGB1 VCL PCNA LRP6 NCK1 MME DAG1 ACTN4 MYO1E JAG1 FYN EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260211%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways STAT3 NOG GAB1 GRB2 SOS1 IL6ST FGFR3 FGFR4 HNF1A ELK1 SMAD5 BMP4 FGF10 MAP2K3 MAPK12 ARAF PIK3R2 PDGFA MAP2K5 FZD1 AKT2 WNT10B WNT10A AKT3 FZD3 MAPK1 AKT1 FZD2 FZD5 FZD7 FZD6 BRAF FZD9 FZD8 SMAD7 MAPK7 FGF1 HRAS FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 SELENOP FGF9 FZD4 SMAD9 FGF18 BMPR1B PTPN11 FGFR1 FGF23 MAP2K2;MAP2K1 WNT9B PDGFRB FGF20 PDGFRA MDM2-2 FGF22 WNT7B FGF21 WNT7A FGF17 MAPK6 FGF16 MAPK4 CTNNB1 FGF14 SMAD1 FGF19 PDGFB FGF13 FGF12 SMAD6 FGF11 WNT5B WNT5A SMAD4 EGF FGFR2 RAF1 JUN LIF BMPR1A BMPR2 PTEN WNT6 DVL1 DVL2 JAK1 DVL3 ACVR1 LIFR WNT1 WNT2 ACTR2 WNT3 ERAS WNT4 ACVR2B WNT3A EGFR GSK3B WNT2B PIK3CD FOS AXIN1 WNT16 MAP2K6 LRP5 LRP6 WNT11 MTOR APC FGF2 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260211%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure CASP3 HSD3B1;HSD3B2 BAX PARP2 CYP11A1 MAPK10 PRDX2 STAR CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260211%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin ADRB1 MAP2K2;MAP2K1 PRKCA MYPN PRKACA-1 GUCD1 CSRP3 NUP62 ANKRD2 ANKRD23 ANKRD1 TTN-1 PRKAR1A MDM2-2 CRYAB TRIM55 GUCY1B1 TCAP PRKG2 SRF MAPK1 ADRB2 CAMK2A RAF1 NBR1 PRKACB-1 FHL1 FHL2 PLCZ1 NPR1 TRIM63 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260211%WP4830%HOMO SAPIENS GDNF RET signaling axis ROBO2 HOXD11 GLI3 HOXA11 SLIT2 IFT27 GATA3 PAX2 RET ROBO1 GFRA1 GREM1 CTNNB1 SOX17 WT1 FOXC2 FOXC1 LHX1 SOX11 BMP4 SALL1 SIX2 AGTR2 ALDH1A2 SPRY1 HSPB11 EYA1 HNF1B GDNF FAT4 HOXC11 BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260211%WP5031%HOMO SAPIENS Biotin metabolism including IMDs PCCA PCCB MCCC1 BTD HLCS MCCC2 PC ACACB ACACA HUNGER AND SATIETY%WIKIPATHWAYS_20260211%WP5445%HOMO SAPIENS Hunger and satiety POMC PYY GHRL AGRP NPY MC4R LEP GCG ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260211%WP4298%HOMO SAPIENS Acute viral myocarditis CYCS-1 CXCR4 CCR5 TGFB1 CASP7 STAT3 CASP2 NFKB2 DFFB DFFA CD4 BID SOS1 ABL1 TNF CASP8 MMP9 RASA1 CASP1 PTCRA ITGAL IL6 EIF4G2 SGCD SGCB ACTB-1 SGCG ENDOG KRT8 ILK JAK1 CASP6 TICAM1 LAMA2 RAC3 CD80 BCL2 PABPC1;PABPC3 NOD2 CD55 HLA-DMA SGCA IL12B GSK3B IL12A EIF4G1 NOS1 PIK3R1 STAT1 CD40LG CASP9 IFNG IL10 CASP3 TLR3 DMD CREB1 IL2 CAAP1 EDN1 CXADR TLR5 MYH6 MAPK1 AKT1 AIF1 CHRAC1 MAPK3 BNIP2 CCR3 ABL2 ITGB2 TLR4 BAX PYCARD BCL2L1 CAV1 PARP1 CCND1 SRC DAG1 SOCS1 FYN STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260211%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 NFKBIA REL TBK1 IKBKG NFKB1 IKBKB CGAS F3 STING1 IRF3 CHUK ITPR1 IL1B IFNB1-4 NLRP3 NFKBIE GSDMD IKBKE NLRX1 RELA LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260211%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G12A PLA2G4F PLA2G12B PLA2G4D PLA2G1B PLA2G4E PLA2G3 PLA2G7 PLA2G10;LOC100652777 PTGS2-2 PLA2G5 PLA2G6 HRAS TP53 CDKN1A PLA2G4A PLA2G2D ALOX5 SLCO2A1 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260211%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways PTK2 MYLK MAP2K2;MAP2K1 SHC1-1 FN1 MAPK8 GRB2 SOS1 CTNNB1 GRIA1 ELK1 TGFA STAT5A PLCG1 MAP2K4 RAF1 JUN NEFL FZD10 DVL1 ERBB4 CDKN1B ACTR2 EGFR GSK3B PAK1 PFN1 NOS1 ACTA1 AXIN1 FZD1 CDKN1A MYC FZD3 WNT16 MAPK1 AKT1 FZD2 NEFM FZD5 NEFH RHOA FZD7 FZD6 FZD9 GPX1 ROCK2 FZD8 SOD1 PPP2CB;PPP2CA PIK3CG WNT11 DAAM1 MYL1 PFN2-1 PFN3 APC ACTR3-1 CAMK1 NCK1 SRC CBL ERBB2 FZD4 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260211%WP5360%HOMO SAPIENS KCNQ2 related epilepsies KCNQ2 PLCG2 KCNQ3 PPP1R10 PRKCA PRKACA-1 SCN1B PPP3CC BDKRB2 CHRM1 AKAP5 ANK3 P2RY1 AGTR1 BACE1 ITPR1 CALM1 CSNK2A1;CSNK2A3 STX1A NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260211%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling GRM8 PHGDH TGFB2 SRR TGFB1 LRRC8C TGFB3 LRRC8D LRRC8B STAT3 NFKB2 DISC1 LRRC8E GOT1-1 SMAD2;SMAD3 IL6ST GLS SHMT1 GRIA1 GLUL ARC PPP1CA SLC1A3 BDNF GFAP LTA DLD SLC17A6 GRIA2 SLC17A7 GRIN3B PPP1CB GRIN3A PPP1CC GRIA3 GRIA4 CAMK4 PDHA1 IL1R1 IL12B CFL1 IL12A IL6R IFNG GRIN2A TGFBR1-1 TRAF5 IL1R2 MAPK1 AKT1 MAPK3 INSR SLC1A4 IGF1 GRIN2C GRIN2B SMAD7 GRIN2D IL13RA1 TNFRSF1B IL1A PLCB4 SOCS3 GRM1 PRKCG PLCB1 PLCB2 PRKCB PRKCA SLC6A9 IL10RA IL10RB IFNGR2 GRIN1 IRS1 TNF CNTF SMAD4 GLS2 DLAT NFKB1 LIF IL6 NGF GRM5 CALM1 JAK1 TGFBR2 GRIK2 BCL2 PRKACA-1 SLC38A2 NOS1 STAT6 STAT1 IL10 IL4R FOS IFNGR1 SLC2A1 IL13 PLCB3 CREB1 IL4 IL1B SLC1A2 CAMK2B TNFRSF1A TGFBR3 CAMK2D SLC38A1 CAMK2A CAMKK1 CAMKK2 ADCY3 ADCY1 ADCY8 LRRC8A PSPH CAMK2G NSMF SLC1A6 SLC1A1 SLC38A3 SLC38A5 TRPM4 DAO GRIK5 GRIK3 GRIK4 PSAT1 FGF2 SHMT2 GRIK1 SLC7A10 GRM2 GRM4 GRM7 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias SKI TGFB1 SKIL STAT3 NOG ZFYVE9 ADAMTSL2 LTBP3 MAPK9 LTBP1 ADAMTS10 SMAD2;SMAD3 ZNF423 ENG BAMBI FBN1 CTNNB1 TGIF1-1 TNF SMAD1 SMAD5 ZEB2 BMP4 SMAD6 SMAD4 EGF RUNX2 JUN NFKB1 LEF1 ITGB6 LIF CREBBP TFE3 THBS1 JAK1 EP300 TGFBR2 WNT1 SPP1 FST INHBA FOXH1 STAT1 IFNG FOS TGFBR1-1 FKBP1A LEFTY2;LEFTY1 TGFBR3 MAPK3 SMAD7 SERPINE1 HRAS RUNX3 SMAD9 GDNF SIGNALING%WIKIPATHWAYS_20260211%WP5143%HOMO SAPIENS GDNF signaling FMOD WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260211%WP399%HOMO SAPIENS Wnt signaling and pluripotency MAPK10 MAPK9 FBXW2 ESRRB CTBP2 NFYA-1 LRRK2 CCND2 PAFAH1B1 CTNND1 PPM1J NKD1 NKD2 CTBP1 PPP2R3B FOXD3 MMP7 MAP2K4 PLAU LEF1 TCF7 TCF7L2 TCF7L1 RACGAP1 CREBBP FZD10 LDLR EP300 PTPA PRKCI PPP2R1B FZD1 WNT10B PPP2R1A MYC WNT10A FZD3 FZD2 FZD5 PPP2R2A;PPP2R2D FZD7 RHOA FZD6 FZD9 FZD8 PPP2CB;PPP2CA CCND1 POU5F1;POU5F1B PRKCG FZD4 PRKCH PRKCB PRKCE PRKCD PRKCA WNT9B WNT7B PRKCQ WNT7A PRKD1 CTNNB1 SOX2 PRKCZ ZBTB33 WNT5B WNT5A FOSL1 JUN CD44 PPP2R5E PPP2R5C WNT6 DVL1 DVL2 DVL3 PPARD WNT1 CCND3 WNT2 WNT3 WNT4 WNT3A TPTEP2-CSNK1E;CSNK1E GSK3B WNT2B PPP2R3A PPP2R2C PPP2R2B AXIN1 AXIN2 WNT16 LRP5 NLK LRP6 WNT11 APC TP53 NANOG;NANOGP8 MAP3K7 SLC25A46 PATHWAY%WIKIPATHWAYS_20260211%WP5521%HOMO SAPIENS SLC25A46 pathway CHCHD3 CHCHD6 EMC1 EMC2 MFN2 EMC3 SLC25A46 EMC4 EMC6 EMC7 EMC8 DNM1L MFN1 APOOL MICOS13 MMGT1 OPA1 IMMT EMC10 MICOS10 APOO UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260211%WP4595%HOMO SAPIENS Urea cycle and associated pathways GLS2 PYCR1 SLC25A13 ASS1 GLUD1;GLUD2 NOS2 ALDH4A1 SLC25A15 NOS1 GOT1-1 GOT2-1 ASL CPS1 NAGS OAT SLC25A12 FH GPT NOS3 LDHB OTC MDH1 ARG1 MDH2 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260211%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation TLR4 PYCARD IL1B NOX1 NFKB1 CTSB CASP1 ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260211%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis ARHGEF1 TBXAS1 RHOA GNA13 GNA12 PTGS1 TBXA2R 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5407%HOMO SAPIENS 15q11q13 copy number variation SIN3A MITF STX1A STXBP1 KAT2B CCL5 SPEF1 SMC5 MTMR10 SMC6 KLF13 NSMCE3 APP OTUD7A NSMCE2 CREBBP NSMCE1 EID3 TRPM1 GJD3 FANCD2 CANX NECAB3 SERPINH1 CALM1 FAN1 LYPD6 CDC42BPB GJC2 UBN1 GCOM1;MYZAP TRPM3 RIC3 SLF1 SLF2 FAM189A1 CGN DNMBP APBA2 TJP3 TJP1 TJP2 ANKRD2 HDAC1 FANCI CXADR CHRNA7;CHRFAM7A OCLN-1 GJA1 RELA IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260211%WP2007%HOMO SAPIENS Iron metabolism in placenta STEAP3 HAMP SLC11A2 SLC40A1 HEPHL1 TFR2 ACO1 MCOLN1 TF IREB2 TFRC SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260211%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism PYY SLC2A4 FFAR3;GPR42 FFAR2 PPARD GCG KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PCYT1A PCYT1B PISD CHKB PCYT2 SGPL1 CHKA PTDSS2 PTDSS1 ETNK1 PEMT CHPT1 ETNK2 CEPT1 BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260211%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders GLS2 GPT ASS1 OTC F10 GATM GAMT F7 GOT1-1 ASL NAGS ARG1 IL4 SIGNALING%WIKIPATHWAYS_20260211%WP395%HOMO SAPIENS IL4 signaling NFKBIA PTPN6 STAT3 SHC1-1 FES GRB2 SOS1 IRS1 IRS2 ELK1 STAT5A STAT5B TYK2 NFKB1 MAPK11 JAK1 EP300 CEBPA CEBPB IL2RG PIK3CD PIK3R2 PIK3R1 STAT6 STAT1 IL4R FOS CHUK IL4 MAPK1 SOCS5 AKT1 PIK3CA MAPK3 DOK2 MAPK14 INPP5D RPS6KB1 JAK3 ATF2 IKBKB JAK2 BAD GAB2 SOCS3 SOCS1 CBL FLNA RELA PTPN11 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260211%WP2001%HOMO SAPIENS miR targeted genes in adipocytes HIPK3 SRSF9 CEBPB IGF2R PICALM CAP1 LPL TMEM43 CSRP1 ELOVL5 FADS1 CYP1B1 SRSF10 TMED10 TGFBR2 PHC2 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260211%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling FBXO32 ACVR2B TNFSF9 EIF2B2 PLD1 GSK3B SMAD2;SMAD3 RPTOR DEPTOR IGF1R MLST8 IRS1 WASL MAP1LC3A AKT1 NEB PRKAB1 TNFRSF1A MSTN IGF1 EIF4E MAPKAP1 RPS6KB1 ITGB1 PIK3CG AKT1S1 NFKB1 MTOR PTEN PPARGC1A ILK RICTOR PDK1 TRIM63 IGFBP5 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260211%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission GABRG3;GABRG2 STAT3 SHC1-1 AP2A1 AP2A2 PIK3R2 PIK3R1 PIK3CB NGFR CREB1 GABRB3 PIK3R3 PIK3CA GABRB2 RHOA GABRB1 GABRE ROCK1 GABRD GABRQ GABRA2 GABRA1 GABRP SLC12A5 BDNF PLCG1 GABRA6 GABRA5 PIK3CG GABRA4 NTRK2 GABRA3 GABRG1 JAK2 AP2B1 PTEN CREM GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260211%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells PRKCB ARRB1 ARRB2 PRKACA-1 GNAS-1 ADCY9 VEGFA MITF POMC PLCB3 ITPR1 CREB1 DCT ADCY4 ADCY2 PMEL ASIP PRKACB-1 TYRP1 MLANA SERPINF1 TYR GNAQ MC1R GPR143 PLCB4 PLCB1 PLCB2 GNA15 FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism SOD2 ACLY HADHB-1 SLC2A4 MTTP ESRRA PPARA STK11 NOS3 PPARGC1B AKT2 ACADM APOB ESR1 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260211%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation EPHB2 WNT3A STAT3 PRKCA CFL2 PRKACA-1 STMN1 GSK3B PAK1 CLASP1 TIAM1 MAPKAPK2 RHO MAP1B ABL1 DIAPH1 CDK1 AKT1 ROCK1 TPPP PARD6A NTRK1 NTRK2 NTRK3 MAPRE1-1 LIMK1 APC CDC42 GNAQ TRIO TESK2 PTEN SPRED1 SRC DPYSL2 MARK2 MARK1 CLIP1 DVL1 RAC1 PTPRA CAMK4 TAOK1 MAPT KIF2C AURKB PHLDB2 F2RL2 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260211%WP4315%HOMO SAPIENS Malate aspartate shuttle SLC1A3 SLC25A11 GOT2-1 MDH1 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260211%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol HSD3B7 IL25 ACOT8 DHCR7 RORC ACOT7 NR1H2 ACOT11 ACOT12 ACOT13 CYP7B1 CYP39A1 SULT2B1 CH25H CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AMACR ACOT6 SLC27A2 ACOT4 IL17F DBP IL17D IL17C IL17B IL17A BAAT ESR1 CYP7A1 SCP2 NR1I2 ACOT2;ACOT1 LBP EPHX2 GPR183 CYP8B1 ACOT9 SULT2A1-4 SLC27A5 HSD11B1 ACOX2 HSD11B2 EBP INSIG1 ESR2 AKR1D1 CYP46A1 THEM5 CYP27A1 BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260211%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPTLC1 KDSR SPHK2 ASAH1 SPHK1 SGPP2 SGPP1 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260211%WP727%HOMO SAPIENS Monoamine transport and regulation IL1R1 FBXO32 CDC25C SLC6A1 SLC6A2 SLC6A4 NOS1 AGT ITGB3 TH ACHE DBH TGFB1I1 HRH3 UNC13B SCAMP2 NECTIN2 TDO2 IL1B ADORA2A TNF SYN1 STX1A MAPK14 SLC6A3 PPP2CB;PPP2CA TNFRSF11B TPH2 RBL2 SLC5A7 AMPH TSC2 ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260211%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SRC SLIT2 RAC1 ROBO4 KDR VEGFA PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260211%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON3 PON2 ESD CES2 PON1 CES1 LIPA CES5A CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260211%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling MAPK14 SMAD4 TGFB1 MAPK9 MAPK8 BMPR1A SMAD2;SMAD3 BMPR2 TGFBR1-1 GREM1 LOXL4 LOXL1 LOXL2 LOX BMP1 TGFBR2 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260211%WP106%HOMO SAPIENS Alanine and aspartate metabolism DARS1 GPT ASS1 GAD1 GOT1-1 GOT2-1 PC ASL GAD2 AGXT ABAT ASPA MEVALONATE PATHWAY%WIKIPATHWAYS_20260211%WP3963%HOMO SAPIENS Mevalonate pathway ACAT2 HMGCS1-1 PMVK MVD FDPS MVK HMGCR SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260211%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis MESP2 HES7 EPHA4 NOTCH1 RIPPLY2 TBX6 DLL1 DLL3 LFNG CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260211%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways SREBF1 DHCR24 DHCR7 LBR NR1H2 CH25H IDI1 FDPS MVK MSMO1 ELOVL5 LSS HMGCS1-1 PMVK MVD HMGCS2 SCD NR1H3 ACAT2 ACSL1 SQLE SOAT1 HSD17B7 ACSL4 TM7SF2 ACSL3 GGPS1 ACOT2;ACOT1 ELOVL4 ELOVL3 SREBF2 SOAT2 ABCG1 HMGCR FADS2 FASN FADS1 MYLIP FDFT1 EBP NSDHL CYP46A1 ELOVL2 CYP51A1 SC5D ABCA1 CYP27A1 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members DTX3L STAT3 BTRC SKP1 STAT6 STAT1 PARP14 PARP9 RBX1 PARP11 CUL1 PARP1 HDAC2 HDAC3 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260211%WP47%HOMO SAPIENS Hedgehog signaling GLI3 SIN3A GLI2 IHH GLI1 DHH PTCH2 KIF7 STK36 PTCH1 SAP18 ARNTL GRK2 SHH SMO ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260211%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction IFNAR1 NOX1 TNF NFKB1 TNFRSF1A ACE2 ICAM1 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260211%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway ASAH1 CERK SGMS1 SGMS2 UGT8 UGCG SGPL1 SPTLC1 SMPD1 KDSR CERS3 CERS4 CERS6 SPHK2 SPHK1 SGPP2 SGPP1 DEGS1 DEGS2 PLPP3 PLPP2 PLPP1 CERS1 CERS2 CERS5 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260211%WP710%HOMO SAPIENS DNA damage response only ATM dependent TGFB1 NFKB2 MAPK10 MAPK9 MAPK8 SMAD2;SMAD3 GRB2 SOS1 BIK CCND2 MAP3K1 PIK3R3 MAP3K4 PLAU LEF1 TCF7 TCF7L2 TCF7L1 LDLR PDK1 RAC3 PIK3R4 PIK3R2 PIK3R1 AKT2 WNT10B CDKN1A MYC WNT10A TP73 AKT3 MAPK1 AKT1 INSR RHOA BAX KRAS PIK3CG SCP2 HRAS CCND1 PIK3R5 ERBB2 PIK3C2G PIK3C2A NRAS PIK3C2B SHC1-1 HMGB1-1 MDM2-2 WNT7B WNT7A CTNNB1 IRS1 ABL1 SOS2 BCL2L11 CDKN2A WNT5B WNT5A SMAD4 FOSL1 JUN ATM PPP2R5E NFKB1 RBL2 PPP2R5C PTEN WNT6 MLKL G6PC1 CCNG2 FASLG DVL1 RAC1 DVL2 DVL3 CDKN1B BBC3 WNT1 CCND3 WNT2 WNT3 WNT4 WNT3A BCL2 GSK3B WNT2B PIK3CD BAK1 PIK3CB PMAIP1 BCL6 AXIN1 WNT16 PIK3CA PIK3C3 CAT WNT11 BAD APC CDC42 TP53 FOXO3 MAP3K7 PCK2 BURN WOUND HEALING%WIKIPATHWAYS_20260211%WP5055%HOMO SAPIENS Burn wound healing FGFR1 CXCR4 TGFB2 TGFB3 COL1A1 HMGB1-1 PDGFRB SMAD2;SMAD3 ACHE HGF COL1A2 FBN1 F13A1 FGFR3 BRD4 FGFR4 TNF CXCL2;CXCL3;CXCL1-1 KLF4 MMP9 MMP28 DCN CCL13;CCL2 EGF TNC CXCR2 MMP2 FGFR2 NFKB1 SNAI2 IL6 FOXE1 HEXD SERPINH1 LGALS1 KRT222 MMP1 SFRP2 KRT6B;KRT6C;KRT6A SCEL S100A11 AMBP SLURP1 LIN28A BCL2 TPT1 FST CDK16 INHBA MYD88 VEGFA CD3E CASP3 CXCL12 ACTA1 IL1B IFNB1-4 S100A6 CXCL8 AKT1 TLR4 BAX CHRNA7;CHRFAM7A NOX4 PECAM1 IL15 ICAM1 TIMP1 TP53 S100A9 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260211%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione GCLC DPEP1 GGCT OPLAH GGT1 GSS HINT1 PATHWAY%WIKIPATHWAYS_20260211%WP5523%HOMO SAPIENS HINT1 pathway NFATC2 CDK7 GTF2H2C;GTF2H2C_2;GTF2H2 JUN CCNH KARS1 NFKB1 GTF2H1 GTF2H3 MAPK9 GTF2H4 ERCC2 SH3RF1 HINT1 ERCC3 FOS RUVBL2 MITF MNAT1 TCF4 CTNNB1 USF2 RUVBL1 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260211%WP696%HOMO SAPIENS Benzo a pyrene metabolism EPHX1 AKR1A1 CYP1B1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1A1 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260211%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis XPO5 DGCR8 DICER1 DROSHA AGO2 ERI1 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260211%WP4537%HOMO SAPIENS Hippo YAP signaling LATS2 MST1 TEAD1 TEAD2 TEAD3 MAP4K1 MAP4K2 MINK1 NF2 SAV1 RASSF1 STK38L TNIK MAP4K3 TEAD4 MAP4K4 CXCL10 YAP1-1 WWTR1 STK3 NDRG1 LATS1 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260211%WP12%HOMO SAPIENS Osteoclast signaling SPP1 IFNAR1 TRPV5 TNFSF11 TNFRSF11B MAPK8 ITGB3 IFNB1-4 GPR68 SLC9A1 AIMP2 PDGFB ACP5 ATP6V1G1 TNFRSF11A CTSK ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260211%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy CACNB3 ITGB3 ITGA2B CTNNB1 ITGA10 ITGA11 ITGA2 ITGB5 EMD DES ITGB4 CDH2 ITGB8 ITGAV LEF1 ITGB6 TCF7 CACNA1D SGCD ITGA3 CACNB1 CACNA1C LMNA SGCB CACNA1F ACTB-1 SGCG TCF7L2 TCF7L1 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 CTNNA1 CTNNA3 LAMA2 CTNNA2 CACNA1S RYR2 ATP2A2 SGCA CACNB2 DMD CACNG1 ITGA1 ACTN3 ACTN1 CACNA2D3 CACNA2D2 CACNA2D4 CACNB4 DSG2 DSC2 ITGB1 CACNG6 CACNG7 CACNG8 CACNG2 PKP2 CACNG3 CACNG4 CACNG5 ITGA4 JUP CACNA2D1 SLC8A1 ITGB7 ACTG1 ACTN2 DSP GJA1 DAG1 ACTN4 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260211%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder NRAS GRIN1 PIK3R3 ARC DLG4 BDNF NF1 UBE3A GRIN3B CACNA1C GRIN3A PTEN CAMK4 SYNGAP1 GSK3B PRKAG1 PRKAG2 PIK3CD PIK3R2 PIK3R1 PIK3CB PRKAA2 PRKAG3 GRIN2A RPTOR AKT2 PRKAB2 AKT3 CAMK2B MAPK1 AKT1 PRKAB1 PIK3CA MAPK3 PRKAA1 GRIN2C GRIN2B GRIN2D RPS6KB1 RHEB KRAS NTRK2 SHANK3 MTOR HRAS HOMER1 GRM1 EIF4EBP1 TSC2 TSC1 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway PTK2 BCL2 NRAS BCAR1 SHC1-1 PIK3R1 GRB2 SOS1 HSPB1 MEF2C AKT2 ABL1 EIF4B PXN BCLAF1 AKT3 BCR SHC4 MAPK1 SHC2 AKT1 MAP3K2 SHC3 CRKL MAPK3 PIK3CA BRAF CRK HSPB2 MAPK14 BCL9 INPP5D DOK1 KRAS RPS6KA1 RAF1 ATF2 MAPK11 SPAG1 HRAS GAB2 VAV1 SRC ARAF CBL GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260211%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PRKCB PRKCE PRKCD ANGPT2 PRKCA PKN2 RCAN1 PRKCI PPP3CA PPP3CB PPP3CC PKN3 GNAQ PRKCQ PKN1 PPP3R1 PRKD1 PRKD3 NFATC1 PLCB3 PRKCZ PRKD2 PRKCG PRKCH NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260211%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling FN1 NFKB2 EIF4A2 ALB MAPK8 IL9 CASP8 SMAD5 MMP25 CRP CCL13;CCL2 CCL11 BST2 CCL5 CCL23;CCL15 APOA2 APOA1 TPO HSPA8 CAMK4 CCL4L2;CCL4L1;CCL4 CCL8 CCL1 IL12A IFNG CD3G CD247 CD3E IFNB1-4 IL17A IL1R2 AKT1 UPF1 DDIT4 CTSB TRAF6 APOC1 JAK2 CTSD ACTG1 ZAP70 MARK2 EIF4EBP1 FYN IGFBP3 PTPN6 IL7 PRKCQ C8A CXCL9 C1QBP NLRP3 CXCL2;CXCL3;CXCL1-1 CXCL13 CXCL10 PF4;PF4V1-1 CCL3L1;CCL3L3;CCL3;CCL18 JUN CFB IL6 ITGA3 IL33 C1S CCL20 ACTB-1 CFI CCL22 CCL21 CCL27 CCL26 CFP CPN1 IRAK1 MYD88 CCNB2 SELP CCNB1 CFH-3 FOS STEAP3 IL1B CDK1 CXCL5;CXCL6 MAP1LC3B2;MAP1LC3B-1 NFATC3 DUSP1 IFIT1 GTSE1 VPS36 WDR74 CD226 SKAP1 TRPM2 BTN3A1;BTN3A3 EGR1 APOM APOH HP;HPR APOD MX1-1 INTS4 HRG CTSZ SDF2 CCR6 TOMM70 PMPCB GP1BA ATP13A3-1 IL16 SRP54 OS9 SRP72 GGH GSN MIB1 LRG1 SRP19 IFI44L AGT CLCC1 ACE2 TLE3 RRM2-1 GTF2F2 G3BP2 PITRM1 NLRP1 NPTX1 MDN1 FAM83A NEK9 CD163 TP53I3 LGALS3BP TRO TRIM59 ITIH3 RAP1GDS1 HIF1A ERLEC1 UGGT2 ADAM9 ATE1 COL7A1 TBKBP1 JUNB FAM98A TLE1 SERPINA5 CARD11 TF HLA-DRA C1R IFITM3;IFITM2;IFITM1 ATG13 IRF9 CEBPB TBK1 ULK1 IKBKG PTGS2-2 DDX58 IFIH1 IRF3 RPTOR DEPTOR MAVS MLST8 VPS11 VPS16 VPS18 GABARAPL2 TRAF3 VPS33A RPS6 LARP1-1 RHEB AKT1S1 NTRK1 PRG3 VPS41 CD2 IGLL5;IGLL1 NKRF CD8A IL18 CD8B;CD8B2 LBP AHR IL1A CD14 MOV10 CCR5 PIAS1 CD4 BID RRAS TNF SMAD1 G3BP1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CXCR1 EIF4E CXCR2 BIRC5 ITIH4 RTN4 CTSV;CTSL CASP5;CASP4 ATP6AP1 RAC1 JAK1 TGFBR2 IL21 IL22 PARP2 IL18RAP TNFSF10 STAT1 CASP9 IL10 APOL3;APOL4;APOL1;APOL2 CXCL12 CASP3 IL13 TRAF2 IL4 IL5 CXCL8 SIGMAR1 LCK SERPINE1 MTOR SAA2;SAA1 FGB FGA FGG FGF2 HBD;HBB ITCH COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260211%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling SREBF1 CEBPA CEBPB SPP1 CEBPD GSK3B SLC2A4 CSNK1A1 CTNNB1 AXIN1 WNT10B FNTA ADIPOQ EMD TOR1AIP1 TLE1 RUNX2 DICER1 LEF1 TCF7 ZMPSTE24 APC LMNA HES1 HES5 CDK6 TCF7L2 TCF7L1 ICMT HMGA2 CCND1 TARBP2 PPARG AGO2 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260211%WP5351%HOMO SAPIENS Kleefstra syndrome H3-3A ASH2L SMARCA2 NCOA6 ACTL6A SMARCA4 EHMT1 SMARCD1 SMARCD2 SMARCD3 PAXIP1 NR1I3 KMT2C DPY30 SMARCB1 PAGR1 RBBP5 WDR5 KDM6A SMARCC1 MBD5 SMARCC2 ACTL6B ARID1B ASXL1 BAP1 RXRA ARID1A AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260211%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways CLCN7 TCIRG1 OSTM1 PLEKHM1 SNX10 RAB7A NFKB1 IKBKB TNFSF11 TRAF6 TNFRSF11A RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260211%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 F12 NOS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BDKRB2 AGT ACE2 AGTR1 KLKB1 PRKG1 IL1B TNF MAPK1 RHOA ROCK1 ACE AGTR2 REN SERPING1 NFKB1 BDKRB1 SERPINE1 KNG1 NOS3 IL1A KLK1 CYP24A1 CPN1 VDR NPR1 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260211%WP5234%HOMO SAPIENS Bardet Biedl syndrome IFT81 GLI3 GPR161 GLI2 IFT27 DYNC2H1 DYNLT2B ARNTL USP9X DYNC2LI1 BBIP1 KIF7 TRAF3IP1 CEP164 PKD2 OCRL FLCN IFT52 TMEM107 CNGA1 NEK1 BBS9 BBS7 TTC21B IFT57 BBS5 CEP290 SCAPER BBS4 IQCB1 MKKS IFT140 IFT80 CFAP410 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 RP2 MAK TMEM216 EFHC1 ZIC2 WDPCP EFHC2 CILK1 INVS CNGB1 CEP104 NPHP3 ARL6 ARL3 PKD1L1 PDE6D CRX PKHD1 ARL13B TMEM67 INPP5E EVC2 BBS2 NEK8 BBS1 WDR19 PCARE SCLT1 IFT172 LCA5 IFT122 DCDC2 RAB23 FUZ IFT74 C8orf37 TTC8 PKD1 MKS1 CEP41 TRIM32 CLUAP1 PTCH1 DYNC2I2 DYNC2I1 SMO METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260211%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II HNMT NAT8L GSTM1;GSTM2-1 EPHX2 GSTA3;GSTA1 GSTA3;GSTA5;GSTA1;GSTA2 CYP2C18-1 CYP1A2 CYP1B1 CYP21A2 AKR1D1 CYP51A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2D6;LOC107987479;LOC107987478-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 COMT CYP7A1 HS3ST2 GAL3ST4 HS6ST1 HS6ST2 SULT2A1-4 HS6ST3 MGST3 NAA80 NDST2 MGST2 NDST1 AKR7A2 AKR7A3 NDST4 NDST3 CYP2R1 GSTK1 GSTM3 CYP46A1 CYP2U1 GSTM4 SULT6B1 HS3ST3A1 GSTCD GLYAT CYP4F22 CYP4X1 CHST11 CHST12 CHST10 CYP7B1 CYP39A1 CHST13 CYP2S1 SULT2B1 CHST14 CYP26A1 CYP27C1 NAT9 NAT10 NAT14 CYP19A1 HS2ST1 SULT1C3 CYP26B1 FMO3 SULT1C2 AKR1B15;AKR1B10 CYP4V2 UGT2A1 GAL3ST3 SULT4A1 CHST8 HS3ST3B1 CHST9 CHST6 NAA30 CHST7 NNMT GSTO2 BAAT TPMT GPX5 KCNAB1 INMT KCNAB2 KCNAB3 NAA40-2 CHST1 CHST4 CHST2 CHST3 GSTP1 CYP2J2-1 NAA20 CYP17A1 NAA50-1 AKR1B1 CYP2F1 NAT8-2 CYP4B1 FMO1 HS3ST5 FMO2 HS3ST6 CYP27B1 FMO4 CYP8B1 HS3ST4 FMO5 HS3ST1 GSTA4 SULT1B1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 GSTZ1 CYP24A1 CYP20A1 GSR CYP27A1 CYP2W1 CYP11A1 CYP2B6 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 GSTO1 EPHX1 CYP11B1;CYP11B2 AKR1A1 GPX4 MGST1 GAL3ST1 UGT1A1;UGT1A6 GSTT2B;GSTT2 CYP1A1 CYP2E1 GSS PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling MAPK8 BID PDGFRA FAS BMF TNF ELK1 BCL2L11 CDKN2A MAP3K5 JUNB MAP2K3 MMP2 MAP2K4 HBEGF JUN MAPK12 CCNE1 MAPK13 MAPK11 HSP90AA1 IL6 FASLG CFLAR BCL3 MAP2K7 BCL2 NFE2L2 EGFR TNFSF10 BAK1 MCL1 IFNG FOS CCNA2-1 TRAF2 IL2 CDKN1A TRAF5 TNFRSF1A TRAF6 MAP2K6 MAPK14 BAX ATF2 BCL2L1 RB1 TP53 FGF7 CCND1 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260211%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death ATG12-1 BCL2 AMBRA1 ULK2 ATG16L1 ULK1 ATG4A CHAF1A INS;INS-IGF2 ATG3 ATG7 MAP1LC3A ATG5 SH3GLB1 UVRAG INSR ATG14 ATG9B TSC2 ATG10 TSC1 VMP1 BECN1 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260211%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 PDIA2 DGAT2 LRP1 SEL1L APOA5 GCK LMF1 LPL MTTP CETP APOA2 FAS APOA1 LCAT APOA4 LIPC ACSS1 APOC2 LDLR PLTP GPIHBP1 GCKR COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome CDCA5 NIPBL SMC1A WAPL PTTG1;PTTG2 ESCO1 ESCO2 REC8 SMC1B SGO1 SGO2 MAU2 STAG2 STAG3 ESPL1 PPP2R1B SMC3 CDK1 PPP2R1A HDAC8 PLK1 PPP2CB;PPP2CA PPP2R5E APC PPP2R5B PPP2R5A PPP2R5D PPP2R5C AURKB PDS5B PDS5A PTPA RAD21 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5380%HOMO SAPIENS 5q35 copy number variation NELFB H3-3A PNPLA2 GAB1 FRS2 MAPK10 MAPK9 ARL10 MAPK8 ADAM10 GRB2 SOS1 FGFR4 FBXW7 COX7C COX5A SNCA GPRIN1 DRD2 CAPN3 PIK3R1 IGF1R MYC HK3 TMED10 CYP7A1 GRIN2B NTN1 FGF1 TMED2-1 EED SRC EIF4E1B CXCR4 PDLIM7 MAX GRIN1 ABL1 BARD1 FGF19 GRK6 PTH PLCG1 JUN HIP1 ABHD5 BRCA1 GNAI3 KDM6B GNAI2 TPM2 F12 KIAA1191 COX6A1 RNF44 UNC5A MYO7B COX6B1 HIC2 DOK3 BRCC3 PRELID1 PTPRN2 NOP16 HIGD2A GNAI1 MXD3 COX7B RGS14 PRR7 COX4I1 SLC34A1 INPP5D FAF2 CLTB DDX41 BABAM1 BABAM2 UIMC1 COX8A TMED9 ARFGAP2 CDHR2 PFN3 FAM193B CDHR5 B4GALT7 DBN1 ABRAXAS1 USH1C MAGED1 COX5B LMAN2 NSD1 RAB24 ZNF346 SNCB HIP1R COX6C SIMC1 TSPAN17 ANKS4B PTPN2 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5275%HOMO SAPIENS Ether lipid biosynthesis PEX19 LPCAT1 PEDS1-UBE2V1;PEDS1 PEX1 ALDH3A2 GNPAT PEX7 PEX5L GAL3ST1 PEX3 DHRS7B AGMO AGPS FAR2 LPIN1 UGT8 LPIN2 LPIN3 FAR1 CEPT1 PEX16 ARSA CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation SNAP25 AP2A1 AP2A2 SLC6A4 MSX2 ALDH1L1 AQP4 SLC18A3 RIMS2 GLS PPFIA1 GATA4 ESRRB BSN UNC13A RBFOX3 NOTCH1 FBXO15 TBR1 SYP ZFP42 CHAT KLF4 GLUL LIN7A LHX1 MIXL1 FUT4 HOMER2 HTR1A BMP4 EVX1 DLG3 FOXD3 FEV CD24 PAX3 NES SLC1A3 DLG4 PCLO ERC1 CASK CD34 PAX6 ADRA2C GFAP ADRA2B MSX1 ADRA2A TUBB3;TUBB6 DLG1 DPPA3 LEF1 DPPA2 SLC17A6 DCX SLC17A7 TBXT NEFL GLRA1 GLRA2 HES1 GLRA3 HES5 GABBR1 HTR5A GLRB FABP7 KRT15 RIMBP2 FOXA2 HOMER3 DLG2 GAD1 GATA6 SHANK1 TH NGFR NLGN1 MAP2 GRIN2B ITGB1 TWIST2 NR4A2 FGF4 CLDN11 SOX9 POU5F1;POU5F1B SLC6A5 SLC6A9 SLC6A1 SLC6A2 DLL1 ACHE HES3 GRIN1 SOX2 GAD2 CSPG4 CNP SLC6A3 TNC MBP CDH2 CDH1 SNAI1 SNAI2 MOG TPH1 OLIG2 SOX10 ITGA6 TPM1 ERAS GPHN GABBR2 KCNJ6 ROBO1 HNF4A SOX17 LMX1B SLC1A2 NEFM PECAM1 CACNG2 SHANK3 NANOG;NANOGP8 HOMER1 NODAL CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP3869%HOMO SAPIENS Cannabinoid receptor signaling DAGLA PRKACA-1 MAPK10 MAPK9 CYP2C9;CYP2C19 MAPK8 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PRKAR1B PRKAR1A ADORA2A MAPK1 MAPK3 PRKAR2B MAPK14 CNR1 ADCY1 MAPK12 ADCY7 MAPK13 MAPK11 PRKACB-1 CYP1A1 AHR FAAH CNR2 NAPEPLD DAGLB TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260211%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3C2G PIK3C2A NRAS PIK3C2B EGFR PIK3R4 PIK3CD PIK3R2 PIK3R1 PIK3CB AKT2 AKT3 MAPK1 AKT1 PIK3R3 MAPK3 PIK3CA ERBB3 KRAS PIK3CG RAF1 HRAS PIK3R6 PIK3R5 ERBB4 ERBB2 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260211%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family IL22 IL25 RORC RORA ID2-1 GATA3 IL12B TBX21 IL12A IL7 TSLP IFNG IL23A IL13 IL9 IL4 IL1B AREG IL5 EOMES HNF1A IL17A TNF NFIL3 ZBTB16 TOX IL6 IL15 IL18 IL33 AHR GFI1 BCL11B MAPK SIGNALING%WIKIPATHWAYS_20260211%WP382%HOMO SAPIENS MAPK signaling TGFB2 PTPN5 TGFB1 TGFB3 NFKB2 MAPK10 MAPK9 MAPK8 GRB2 SOS1 HSPA1A;HSPA1B FGFR3 MEF2C LRRK2 FGFR4 SRF MAP3K1 ELK1 FGF10 RPS6KA3 MAP3K4 BDNF MAP2K3 MAP2K4 MAPK12 MAPK13 MAPK11 MAP3K11 CACNB1 GNA12 HSPA8 HSPA1L MAPK8IP3 MAPK8IP1 HSPA6 ECSIT DUSP3 IL1R1 DUSP8 HSPA2 DUSP9 DUSP7 RAPGEF2 NTF3 TAOK3 RASGRP2 STMN1 CACNA1E RASGRP4 CACNA1H CACNA1G CACNB2 CACNA1I MAP3K20 MAPKAPK2 RASGRF2 DUSP16 PDGFA PPM1A TGFBR1-1 RAP1B PPM1B RASA2 CACNG1 MAP2K5 PTPN7 AKT2 MYC AKT3 IL1R2 MAPK1 AKT1 MAPK3 TRAF6 BRAF CRK MAPK7 MKNK1 KRAS ATF2 NTRK2 FGF1 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 TAOK1 PRKCG FLNA FGF18 FGFR1 PRKCD PRKCA CACNB3 FGF20 FGF22 FGF21 FGF17 FGF16 ATF4 FGF14 FGF19 FGF13 FGF12 FGF11 JUN NFKB1 FLNC NGF FASLG MKNK2 NTF4 ARRB1 TAB2 ARRB2 PRKACA-1 FOS HSPB1 IL1B CACNA2D3 CACNA2D2 NR4A1 CACNA2D4 NFATC3 CACNB4 DUSP4 DUSP1 CACNG6 DUSP6 CACNG7 NLK CACNG8 CACNG2 CACNG3 CACNG4 PRKACB-1 CACNG5 RPS6KA4 RPS6KA5 MAP3K8 MAP3K6 MAP3K7 MAP3K12 DUSP2 JUND MAP4K1 MAP4K2 FLNB TAOK2 MAP4K3 MAP4K4 MAP3K2 RASA1 PAK2 CACNA1B CACNA1A STK4 ARAF DDIT3 RAC3 RELB IKBKG PPP3R1 MAP3K14 NTRK1 IKBKB PPP3CA PPP3CB PPP3CC CACNA2D1 HRAS IL1A MAPT RASGRP1 RELA CD14 FGF23 PPP5C NRAS MAP2K2;MAP2K1 CDC25B PDGFRB MAX RASGRF1 MAPKAPK5 RRAS2 RASGRP3 FAS RAP1A RRAS MRAS DUSP10 SOS2 TNF GADD45A PDGFB MAP3K5 EGF FGFR2 RAF1 NF1 LAMTOR3 TAB1 MAP3K13 CACNA1D CACNA1C CACNA1F JMJD7-PLA2G4B;PLA2G4B PLA2G4A RAC1 CACNA1S MAP2K7 TGFBR2 EGFR PAK1 CASP3 CHUK NFATC1 TRAF2 TNFRSF1A CRKL ELK4 MAP2K6 DAXX MAPK14 PLA2G4F PLA2G4D PLA2G4E SMIM40 PTPRR CDC42 TP53 MAPKAPK3 FGF2 STK3 MAPK8IP2 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP4159%HOMO SAPIENS GABA receptor signaling GPHN GABRG3;GABRG2 AP2A1 SLC6A1 GAD1 AP2A2 GABBR2 ABAT AP2M1 ALDH9A1 SLC32A1 GABRB3 GABRB2 GABRB1 GABRE GAD2 GABRD GABRQ GABRA2 GABRA1 GABRP GABRA6 GABRA5 GABRA4 GABRA3 GABRG1 AP2S1 SLC6A11 GABBR1 AP2B1 EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260211%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria SREBF1 MTA1 H3-3A SUV39H1 LEF1 E2F1 HDAC1 RB1 KDM1A TP53 CBX3-1 HDAC2 MBD2 RBBP4 MBD3 CBX1 CHD4 CHD3 RBBP7 MTA2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MTA3 CBX5 INPP5K KALLMANN SYNDROME%WIKIPATHWAYS_20260211%WP5074%HOMO SAPIENS Kallmann syndrome FGFR1 ASCL1 LHB MAP2K2;MAP2K1 PROK2 FRS2 PLXND1 NEUROG1 OTX2 OLIG2 MYRF SOX10 GRB2 CHD7 GNRH1 FGF8 MAPK1 PROKR2 AKT1 PIK3CA SEMA3E ANOS1-1 TMEM98 PTPN11 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260211%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma PINK1 SHOC2 STAT3 KRAS NFE2L2 NFKB1 PRKN HMGB1-1 SQSTM1 MDM2-2 MITF AGER TP53 TFE3 ATG7 TFEB MAP1LC3B2;MAP1LC3B-1 VMP1 IPO8 BECN1 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence DPEP1 PTGS2-2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2D6;LOC107987479;LOC107987478-1 ELOVL5 ALOX12 LTC4S FPR2 ALOX5 LTA4H GPR32 ALOX15B GSTP1 HPGD ALOX15 PTGS1 EPHX2 FADS2 PTGDS CYP2E1 PTGIS GGT1 FADS1 PLA2G4A CYP1A2 TBXAS1 GSTM4 ELOVL2 PTGES SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260211%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling HTR4 HTR6 MAP2K2;MAP2K1 ATF1 HTR7 GNAS-1 MAPKAPK2 RPS6KA5 RAP1A CREB1 EGR1 SRF MAPK1 NR3C1 ELK4 MAPK3 ELK1 BRAF MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260211%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome KIRREL1 TJP3 TJP1 TJP2 PRKAG1 PRKAG2 PRKAA2 PRKAG3 CTNNB1 PRKAB2 PRKAB1 PRKAA1 PYGO1 BCL9 F11R GJA3 AMELY;AMELX GJA5 ACP6 OCLN-1 GJA8 CHD1L PYGO2 AFDN GJA1 FMO5 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260211%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex H2BC21 EP400 KAT2A KAT2B HAT1 ASF1A ASF1B CREBBP HDAC2 RBBP4 MBD3 EP300 TLK2 HDAC1 MBD2 CHD4 CHD3 MTA2 MAPK3 MTA1 H2BC5 PWWP2B UBTF H2BC1 PWWP2A H4-16 TBP H2AZ2;H2AZ1 POLR1A H2AJ POLR1B POLR1C H2BC15;H2BC3;H2BC11;H2BC12 H2AC14 POLR1D RRN3 H2AC20 SRCAP H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TAF1D TAF1B TAF1C H4C1 TAF1A TAF12 GATAD2B GATAD2A H2AB2;H2AB3;H2AB1 H4C6 CDK2AP1 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260211%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids DGAT2 GPAT4 CDIPT DGAT1 PNPLA3 PLA2G1B DGKZ PNPLA2 PLD1 PCYT1A PISD CHKB PCYT2 PTDSS2 PTDSS1 ETNK1 PEMT CHPT1 GPAM CDS1 CRLS1 AGPAT4 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260211%WP699%HOMO SAPIENS Aflatoxin B1 metabolism EPHX1 AKR7A2 CYP2A13;CYP2A6;CYP2A7-1 CYP1A2 AKR7A3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GSTM1;GSTM2-1 CELL CYCLE%WIKIPATHWAYS_20260211%WP179%HOMO SAPIENS Cell cycle TGFB2 TGFB1 TGFB3 SMAD2;SMAD3 CCND2 CCNE1 CUL1 HDAC2 EP300 E2F2 SKP1 RBX1 SMC3 CDKN1A MYC ZBTB17 CDK4 CDK2 E2F4-1 RB1 CCND1 CHEK2 PRKDC CHEK1 RAD21 TFDP2 CDC14A CDC14B CDC23 CDC25A SKP2 CDC25B ANAPC7 ANAPC4 MCM2 MAD2L2 ANAPC5 STAG1 CDKN1C MAD1L1 ANAPC2 ANAPC13 PKMYT1 MDM2-2 ANAPC10 ANAPC11 ORC5 ORC4 ORC6 ORC1 CDC20 ORC3 ORC2 ABL1 CDC7 CDC6 CDC16 MCM7 DBF4 GADD45A MCM3 PLK1 MCM5 MCM6 TTK CDKN2A FZR1 CDC45 BUB3 SMAD4 BUB1 WEE2 SFN CDK7 MCM4 ATM ATR CDKN2D RBL2 CDC27 RBL1 TFDP1 CDKN2B CDKN2C E2F5 CDKN1B YWHAE CCND3 YWHAB ANAPC1 SMC1A CDC25C PTTG1;PTTG2 CCNH CCNE2 GSK3B YWHAQ E2F1 SMC1B CCNB3 HDAC1 CCNB2 YWHAG CCNB1 YWHAH STAG2 GADD45B YWHAZ ESPL1 GADD45G WEE1 CCNA2-1 CDK1 CCNA1 PCNA CDK6 E2F3 TP53 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260211%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL5-1 RPLP2 RPS19 RPL10A RPS27A RPS6KA3 RPL4 RPS6KB2 RPLP1-2 RPL3 RPL32 RPL31 RPL23 RPL34 RPLP0 RPL8 RPL9 RPL6 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL13A-1 RPS18 RPL37A-1 RPL35 RPL38 RPL36-1 RPS10 RPL39 RPL11 RPL15-1 RPS13 RPS12 RPS9 RPL18A RPL21 RPS7 RPS8 RPS5 RPL22 RPS11 RPS3A RPSA RPL24 RPL29 RPL28 RPL10;RPL10L-1 MRPL19 RPS15A RPL14 RPS3 RPL13 RPS2 RPL12-1 RPL18 RPL17 RPL19 RPL35A RPL23A RPL3L FAU RPS25 RPS27 RPS29 RPL27A RPS20 RPS21 RPS6 RPS24 RPS23 RPL30 RPS6KB1 RPS6KA1 RPS6KA2 UBA52 RPL7 RPS6KA6 RPL27 RPL26 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2858%HOMO SAPIENS Ectoderm differentiation EDA2R WDR44 PHF8 SIX6 SKIL BOC RAB8B BCAS3 TSC22D1 SORCS1 HDAC10 PIM1 BAZ1A TOX3 FOXL1 ARHGAP10 KIFC3 STX16 RRBP1 IQCJ-SCHIP1;SCHIP1 SERPINB6-2 CLVS1 TTC14 C1GALT1 VAX2 RIT1 PTPN13 GLB1 SGSM3 ZNF219 CTBP1 LHX1 BCOR TRIM33 MYORG BMP4 SHH CCL13;CCL2 PAX3 HDAC6 PAX6 TNFRSF11B POU2F2 FHL2 NF2 TCF7L1 SNCA FOXA2 CDON CTNNA2 GATA6 TFAP2A DMD MYC NUMA1 FZD5 NLGN1 ZBTB16 RGMA SDCBP FZD8 GAS2L1 JUP UBTF MKS1 LDB2 CLDN11 CELSR2 SOCS2 FZD4 FYN GLI3 MAFB CTNNB1 SOX2 CDH8 SMAD4 CDH6 FGFR2 ELOVL4 BMPR1A CAP2 SPRY2 KRT6B;KRT6C;KRT6A PPARD WNT1 ELOVL2 PODXL JAKMIP1 PRKAG2 NFATC1 ABCC4 PGM1 CTNND2 ARHGDIG TSKU NARS2 ANKS1B KCNK10 GRAMD1B-1 TLE5 ROR2 NLK PDE7A MZF1 LY6E ASTN1 ARX STC1 ARHGAP15 ZBTB2 ST8SIA4 HESX1 ZFHX4 PLXNA2 ZBTB7B TFAP2C SMURF1 OGT-1 GREB1 TRPM2 NR2F2 PAN2 AHI1 PTPRB PLCXD3 PPFIBP2 CCDC88C PI4KA CCDC130 EDA HMGB2 MECP2 CAMKK2 PATHWAY%WIKIPATHWAYS_20260211%WP4874%HOMO SAPIENS CAMKK2 pathway HFE IFI44L DNM1L NLRP1 SIRT1 ATP1B2 HIF1A MID1 SPINT1 CYB5R3 TSPAN8 FIS1 WFS1 TRPV4 MS4A3 OASL CCR9 CCNE1 CTSE ERMAP CCL5 GALNT9 SPIRE1 GIT1 MAMDC2 C1QTNF12 TBXT FAM20C ARHGEF7 ACACA ATP10D TSPAN33 FASN SLC25A21 AHSP TMEM176B IRGC KLF1 SLCO3A1 RHAG KEAP1 CAMK4 EP300 SREBF1 ASNS ULK1 STIM1 CXCL11 WDR35 CRTC2 CD28 RPTOR CPOX GATM MAPK1 MAPK3 RPS6 VCAM1 RPS6KB1 SQSTM1 CHRM3 MAF CCND1 S100A8 RASGRP1 HMBS TSC1 RELA CDC25A PFKFB2 KDR TNF CDH1 RAF1 CALM1 RAC1 HK1 GCK NFE2L2 SMC1A PAK1 SLC2A4 NOS1 EPOR PLAC8 SELL SLC2A1 CREB1 AQP1 MAP1LC3A HDAC4 PFKFB3 MAP1LC3B2;MAP1LC3B-1 NFATC2 HK2 CAMKK2 MTOR IL15 CAMK1 ICAM1 PARP1 SLC38A5 HMOX1 NEDD4L PCK2 ABCA1 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260211%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNA3 CHRNB4 CACNA1G CACNA1C RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260211%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis MAPKAP1 EGFR MTOR TP53 MLST8 PTEN AKT2 FOXO3 AKT3 RPL11 AKT1 PIK3CA RIOK2 RICTOR RIOK1 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260211%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 TLR3 MAVS DDX58 TLR7 IFIH1 IRF7 MR1 IRF3 TLR8 TNFRSF11A GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260211%WP3958%HOMO SAPIENS GPR40 role in insulin secretion PLCG2 GNA11 PLCG1 PLCH1 PLCD3 PKD1 PLCB3 PLCZ1 ITPR3 PLCE1 PLCB1 PLCD1 PLCB2 PLCL1 FFAR1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260211%WP3407%HOMO SAPIENS FTO obesity variant mechanism IRX3 PRDM16 ARID5B FTO PPARGC1A TBX1 IRX5 UCP1 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260211%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 MGMT DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260211%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection CBFB CUL5 ELOB ELOC-1 RUNX1 UBB;UBC RBX1 NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism NEU2 B4GALT3 FUT1 B4GALT1 FUCA1 ST3GAL4 NAGA FUT2 FUT6;FUT5;FUT3 B3GNT5 B4GALT4 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260211%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway IGFBP7 TGFB1 NFE2L2 FN1 EXOC6 SUV39H1 COL2A1 NQO1 PKD1 DDR1 ANXA5 SIRT1 NRF1 FGF7 BMP2 LOXL4 CDC37 ECSIT SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome RAD50 MDC1 NBN RAD18 BRCA1 SMC1A SMC3 PAXIP1 ATM MRE11 RAD21 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260211%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells CCL13;CCL2 CD40 TGFB2 TLR4 VCAM1 TGFB1 TGFB3 CCL5 TLR2 SELE SELP CD40LG SELPLG ICAM1 IL1B TLR7 PF4;PF4V1-1 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP5304%HOMO SAPIENS Cholesterol metabolism LIPA CD36 ACAT2 STARD3 HSD17B7 TM7SF2 LPL TSPO MTTP CETP APOA2 PCSK9 APOA1 LCAT APOA4 MYLIP NPC1L1 LIPC APOB LDLRAP1 LDLR EBP PLTP NSDHL CYP51A1 CYP27A1 SC5D DHCR24 DHCR7 LBR VDAC1 IDI1 FDPS MVK MSMO1 LSS HMGCS1-1 PMVK APOE NPC1-1 MVD LIPG ANGPTL8 ANGPTL3 SLC27A4 LRPAP1 SAR1B MGAT1 APOC2 OSBPL5 APOC3 ABCG8 CIDEB ABCG5 FABP2 VAPA LRP1 CYP7A1 DGAT1 SQLE SOAT1 APOC1 SCARB1 SORT1 HMGCR NPC2 ABCB11 APOH FDFT1 STAR ABCA1 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260211%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor DDX1 RAD50 NBN DGCR8 DROSHA ATM MRE11 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260211%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC1A5 ATF4 SLC7A11 NFE2L2 KEAP1 SLC7A5 SLC3A2 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260211%WP4249%HOMO SAPIENS Hedgehog signaling ARRB1 BCL2 GLI3 GPR161 ARRB2 GLI2 BOC TPTEP2-CSNK1E;CSNK1E PRKACA-1 CSNK1A1 EVC DHH CCND2 GRK2 SHH CUL3 HHIP EVC2 GRK3 SPOP CSNK1G3 SMURF2 FBXL17 SPOPL GAS1 PRKACB-1 CSNK1G2 IHH GLI1 CSNK1G1 PTCH2 KIF7 SMURF1 PTCH1 CCND1 CDON LRP2 CSNK1D SMO KIF3A LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260211%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 FADS2 ELOVL5 FADS1 ACOT2;ACOT1 ACE2 ELOVL2 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260211%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells SLC1A5 SLC2A1 PHGDH PSPH GLS SLC7A11 PSAT1 ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260211%WP2374%HOMO SAPIENS Oncostatin M signaling PRKCB NFKBIA PRKCE PRKCD CASP7 PRKCA MAP2K2;MAP2K1 STAT3 SHC1-1 MAPK9 JUND MAPK8 GRB2 SOS1 IL6ST IRS1 PXN HIF1A JUNB STAT5B RAF1 TYK2 NFKB1 JAK1 CDKN1B LIFR CEBPB PIK3R1 STAT1 FOS VEGFA CASP3 CREB1 MAPK1 AKT1 MAPK3 RPS6 MAPK14 PTK2B CDK2 JAK3 KRAS OSMR JAK2 PIAS3 MTOR HRAS OSM SRC EGR1 SOCS3 RICTOR PRKCH RELA PTPN11 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260211%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness PTK2 PLCG1 RYR3 JUN ITGAV TNNC1 ITGB3 MFAP5 PRKCQ CREB1 ITPR3 MAPK1 MAPK3 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260211%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis MESP2 WNT3A HES7 FGF8 EPHA4 NOTCH1 RIPPLY2 TBX6 DLL1 LFNG HES1 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260211%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption RAB5C ARHGDIA PRKACA-1 GNAS-1 DYNC2H1 ADCY9 AQP4 AVP CREB3 NSF RAB11A STX4 CREB1 CREB3L3 CREB3L4 CREB3L1 DYNC1H1 DCTN1 VAMP2 DYNC2LI1 DYNC1LI2 ARHGDIG ADCY3 DYNC1I1 RAB5A CREB3L2 ADCY6 PRKACB-1 DCTN6 DYNC1I2 DCTN5 RAB5B DCTN2 DCTN4 AQP2 AQP3 RAB11B ARHGDIB AVPR2 DYNC1LI1 CREB5 ESTROGEN SIGNALING%WIKIPATHWAYS_20260211%WP712%HOMO SAPIENS Estrogen signaling MAPK14 BCL2 MAP2K2;MAP2K1 JUN GNGT1 IKBKG GNAS-1 PRKACA-1 NFKB1 IKBKB MAPK9 SP1 FOS CHUK GNB1 CREB1 GPER1 MAPK1 AKT1 PIK3CA ELK1 BRAF ESR1 CORI CYCLE%WIKIPATHWAYS_20260211%WP1946%HOMO SAPIENS Cori cycle GPI SLC2A4 GAPDH-1 SLC2A1 SLC2A2 GPT INS;INS-IGF2 TALDO1 LDHA ALDOA G6PD PGK1 TPI1 PGAM1 HK1 PFKP LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP4478%HOMO SAPIENS LTF danger signal response pathway IRAK4 CD14 TLR4 TREM1 MYD88 NFKB1 TLR2 IL6 AGER IL1A IL1B IFNB1-4 CXCL8 TNF MAPK1 TRAF6 LTF IRAK1 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260211%WP5382%HOMO SAPIENS TGFB Smad signaling TGFBR1-1 SMAD4 TGFBR3 SERPINE1 SMAD2;SMAD3 YWHAG WWTR1 POSTN TGFBR2 SPARC CCN2 RAS SIGNALING%WIKIPATHWAYS_20260211%WP4223%HOMO SAPIENS Ras signaling PLD1 GAB1 MAPK10 MAPK9 MAPK8 GRB2 SOS1 FGFR3 ARF6 FGFR4 RASA1 PIK3R3 ELK1 PAK2 LAT BUB1B-PAK6;PAK6 STK4 CALML6 ETS1 CALML3 CALML4 PAK3 PAK5 PAK4 RAC3 SYNGAP1 REL SHOC2 PLA2G2A-1 RASGRP2 IKBKG RASGRP4 PIK3R2 TIAM1 PIK3R1 RASGRF2 GRIN2A FLT1 RAP1B RASA2 IGF1R NGFR RASSF1 AKT2 AKT3 MAPK1 AKT1 MAPK3 INSR FLT3 RHOA EPHA2 GNG10 GRIN2B KRAS NTRK1 NTRK2 IKBKB KIT AFDN HRAS GAB2 ETS2 RAB5B ZAP70 RASGRP1 PRKCG PLA1A RELA RASAL1 PTPN11 PRKCB RASAL2 FGFR1 RALA-1 RASAL3 TTBK1 BRAP NRAS RGL1 PRKCA RGL2 MAP2K2;MAP2K1 SHC1-1 CSF1R RASA4;RASA4B PLAAT3 RASA3 RAPGEF5 EXOC2 PLA2G2F KDR PLA2G2E PDGFRB PLA2G2C PDGFRA RASGRF1 GRIN1 RASGRP3 RRAS2 RAP1A RRAS MRAS ABL1 SOS2 MET SHC4 SHC2 SHC3 PLCG2 FLT4 PLCG1 FGFR2 RAF1 NF1 NFKB1 GNG13 PLA2G5 PLA2G6 GNB2 JMJD7-PLA2G4B;PLA2G4B GNB1 GNB4 GNB3 GNB5 PLA2G4A KSR2 FASLG CALM1 RAC1 CALM2 RAB5C GNGT1 EGFR PRKACA-1 RASSF5 PAK1 PIK3CD PIK3CB TEK CHUK KSR1 PIK3CA PLCE1 ABL2 PLA2G2D PLA2G12A RIN1 PLA2G4F PLA2G12B FOXO4 PLA2G4D PLA2G1B PLD2 PLA2G4E HTR7 PLA2G3 RAB5A RALGDS BCL2L1 PLA2G10;LOC100652777 BAD PRKACB-1 GNG2 GNG5 GNG4 CDC42 GNG8 RALBP1-1 CALM3;CALM1 RALB GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260211%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts HS3ST3A1 CHST11 CHST12 CHST13 CHST14 CHPF XYLT2 XYLT1 HS2ST1 EXTL2 EXTL1 DSE CHST15 CHSY3 EXTL3 CSGALNACT1 CHPF2 HS3ST3B1 B3GAT3 GLCE B3GAT2 B3GAT1 CHST7 CSGALNACT2 B3GALT6 EXT2 CHSY1-1 UST CHST1 CHST3 HS3ST2 B4GALT7 EXT1 HS6ST1 HS6ST2 HS6ST3 HS3ST1 NDST2 NDST1 NDST4 NDST3 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260211%WP1971%HOMO SAPIENS Integrated cancer pathway BCL2 CDC25A CDC25B MSH6 E2F1 MSH2 BLM SMAD2;SMAD3 STAT1 MDM2-2 CASP9 CASP3 RAD50 CDKN1A CDK1 MYC BARD1 BACH1 CASP8 AKT1 PLK1 MAP3K5 BAX CDK4 CDK2 NOXA1 ATF1 ATM POU2F1 BAD ATR RB1 MRE11 CDKN2B TP53 PTEN BRCA1 CHEK2 CHEK1 JAK1 CDKN1B MMP1 BBC3 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260211%WP2005%HOMO SAPIENS miR targeted genes in muscle cell VEZT SRPRB-1 PWP1 NELFCD ANPEP CHORDC1 CIAO2A SEC62 COL1A1 CCN1 IFRD1 PISD DHX40 CARHSP1 METTL7A-1 KCNQ1 COMMD9 ATP6V0A1 SNX6 SRF RAB27B POLA2 NCEH1 PDE3A ANP32B RARS1 NRP1 TRAM1 GFM1 PTPRJ MAGT1 COIL TMED3 MAPK12 DHX15 GNL3L-1 GNPNAT1 TMED7 CTSC GRIA2 MRPS24 RHOG AP3B1 GAK CDCP1 UBE2J1 CSDE1 FRG1 AGO3;AGO1 PTMA TDG BRPF3-1 SSNA1 AMIGO2 NAPG PTPA NT5E PGRMC1 ATAD3A;ATAD3B SHOC2 MPZL1 ARHGDIA SPRYD4 AP3D1 PRKCI SPCS3 TPPP3 NEDD4 ACAA2 P4HA2 CPOX ARID4B CDKN1A UBE4A CDKAL1 DOCK7 GPD2 WDFY1 MATR3 GEMIN7 RAI14 TMED10 SLC1A4 SYPL1 SDCBP MAPK7 TBCA IGF2R KRAS CHMP2A PICALM KIT DOCK5 TNFAIP2 ADAR CHD1 LMNB2 TMEM109 SCYL1 PPIB TMED2-1 HSDL1 GJA1 COL3A1 ARID1A RCN2 RFT1 RBMS1 NXN ERBB2 PHLDB2 GNA13 CAND1 POLD2 PDLIM5 CDIPT PDLIM7 GALNT7 GALNT1 POLE4 SLC4A7 FMNL2 NAA15 SPTLC1 LAMC1 C1QBP ITGA2 ITGB4 LAMC2 THBS1 G6PD CDKN1B ATP2A2 BCL2 YWHAQ TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CCNG1 SLC7A11 BACH1 HDAC4 SLC38A1 DSG2 ABCG2 CLOCK HMOX1 ATP6V1C1 TXNRD1 SLC12A4 ATP6V0E2;ATP6V0E1 SNAP23 PTPRF COL1A2 NOTCH2 TYMS NOTCH1 NF2 HES1 GPAM DNMT3A CYP1B1 CYP51A1 EZH2 CEBPB GFPT1 CALCOCO2 VPS39 ATG9A SPARC EHMT2 EHMT1 CLDN1 PKM RHEB RAVER2 CDK5RAP1 ANKFY1 CDK5RAP3 TMEM41B-1 PPP3CA MBNL1 RB1 CACNA2D1 FNDC3B FNDC3A SCAMP1 BACE1 MTHFD2 WDR82 FAR1 CCND1 HACD3 MRPL20 RDH10 GRPEL2 CSNK1D GSTM4 CAPG MOV10 SFXN1 STRN ASH2L MRC2 PANX1 TMEM43 CSRP1 SH3BGRL3 ELMOD2 CTNNB1 SLC7A6 ZEB1 CSF1 PXDN IRS1 ERG PAFAH1B2 MET PPP1R7 USP1 PLK1 SRSF10 ERBB3 TTC9C ESR1 HIPK3 EIF4E TMEM87A ARCN1 WNT5A HYAL3 WDR11 AXL VSNL1 NFIA FSTL1 SNX15 CA12 NUCB1 PPIF PKN2 CAMTA1 LAMTOR3 ACVR1B LAMTOR5 LPL TUSC2 LTN1 ARF4-1 LCLAT1 IPO4 FADS2 ABHD10 RTN4 POGLUT3 KPNA3 MYLIP TPM4 TPM3 TPM2 TPM1 NCOA3 STX7 RAB30 DMTF1 TGFBR2 RAB34 ANAPC1 PODXL SRSF9 CBFB UAP1 CORO1C EGFR SLC9A3R2 RAB6A SLC38A2 E2F1 MCL1 CD164 SLC4A10 NCL-1 CXCL12 CNOT9 SLC25A1 SYNE2 SYNE1 ACP2 SNAP29 PGM1 ATRX RAD23B PTBP2 ADIPOR2 LRP1 MAPK14 SLC25A13 MTPN SEC23A LUZP1 NUFIP2 UHRF1 TXN2 HSD17B12 MTRR DNAJB1 POLR2C TP53INP1 IGF2BP1 CDK6 SH3BP4 E2F3 LRRC8A ZNF622 SLC25A24 SLC12A2 SLC38A5 SEC24A MYO10 TM6SF1 MYO1E PSAT1 FGF2 PDCD4 SLC25A32 CUL4B BET1 CPNE8 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260211%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide CD80 TGFB1 IL12A IFNG IL10 VIP CD28 FAS IL2 IL4 IL5 CTLA4 CD86 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260211%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid ACSS2 GLYAT GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP4970%HOMO SAPIENS Galanin receptor pathway CDKN1C SLC2A4 IL6 FOS VEGFA POMC INS;INS-IGF2 CREB1 CDKN1A PPARG CDKN1B YAP1-1 VAMP2 BCL2L11 ADIPOQ CRP EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260211%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells TGFB2 WNT3A NRAS TGFB1 TGFB3 EGFR SMAD2;SMAD3 HGF TGFBR1-1 CTNNB1 AXIN1 MET AKT1 TGFBR3 TGFA TSPAN8 PROM1 SMAD4 WNT5A MFGE8 KRAS RAF1 MTOR APC HRAS ERBB2 TGFBR2 DKK4 FOCAL ADHESION%WIKIPATHWAYS_20260211%WP306%HOMO SAPIENS Focal adhesion BCAR1 MYLK FN1 MAPK10 COL1A1 MAPK9 MAPK8 GRB2 XIAP SOS1 CCND2 ELK1 ARHGAP35 PIP5K1C FLT1 PDGFA RAP1B IGF1R AKT2 BLK DIAPH1 AKT3 MAPK1 AKT1 MAPK3 RHOA BRAF CRK ROCK1 IGF1 ROCK2 PGF ITGB1 MYLK2 COL2A1 TNXB VAV1 RELN VAV2 VEGFB ACTG1 TESK2 VEGFC VEGFD SRC ACTN4 PRKCG TNN ERBB2 TNR FLNA FYN COL4A2 COL4A1 PRKCB PTK2 COL4A4 COL4A6 PRKCA SHC1-1 CHAD MYL2 ITGB3 ITGA2B LAMC1 IBSP ITGA10 COL5A3 ITGA11 COL5A2 ITGA2 ITGB5 LAMC3 TNC ITGB4 LAMC2 JUN ITGB8 ITGAV ITGB6 LAMA5 VWF ITGA3 FLNC ACTB-1 COL6A2 ITGA8 ITGA7 THBS1 ITGA6 ITGA5 VTN ITGA9 LAMA2 LAMA1 LAMA4 CCND3 LAMA3 THBS2 THBS4 SPP1 BCL2 THBS3 LAMB3 LAMB2 LAMB1 ACTN1 BIRC2 BIRC3 PDGFD COL1A2 FLNB PXN PIK3R3 PAK2 PPP1CA PPP1CB PPP1CC BUB1B-PAK6;PAK6 ILK PAK3 PAK4 RAC3 PIK3R2 PIK3R1 PPP1R12A ITGA1 PPP1R12B PPP1R12C VCL HRAS CCND1 MAP2K2;MAP2K1 KDR PDGFRB PDGFRA RASGRF1 PDPK1 HGF RAP1A CTNNB1 MET SHC4 SHC2 SHC3 PDGFB CAPN2 PDGFC EGF RAF1 MYL5 MYL7 TLN2 TXK MYL12A MYL12B MYL10 VASP SRMS PARVB MYLPF PARVG PTEN ARHGAP5 ZYX MYLK3 MYLK4 RAC1 CAV3 TLN1 TNK1 PARVA FGR DOCK1 STYK1 EMP2 EGFR PAK1 GSK3B PIK3CD PIK3CB CAV2 VEGFA CRKL PIK3CA HCK RAPGEF1 TNK2 BAD CAV1 PTK6 ITGA4 CDC42 ITGB7 VAV3 COMP RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260211%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260211%WP661%HOMO SAPIENS Glucose homeostasis INS;INS-IGF2 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5408%HOMO SAPIENS 15q25 copy number variation RNMT BNC1 ADAMTSL3;ADAMTSL1 TENT4B AP3M2 BTBD1 C15orf40 FSD2 WDR73 WHAMM AP3D1 SHANK1 SEC11A NMB SPCS3 NMBR AP3B2 AP3S2;AP3S1 CPEB1 SPCS2 SPCS1 SLC2A1 ALPK3 SLC28A1 PDE8A ZSCAN2 ITPR1 SH3GL3 HOMER2 TOP1 EGF RAF1 SHANK3 SYNJ1 HTT GRM5 AGAP2 TM6SF1 GRM1 RYR1 DNM3 RYR2 RAMAC ZNF592 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260211%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism HSD3B1;HSD3B2 CYP11A1 CYP17A1 POR CYP19A1 CYP11B1;CYP11B2 CYB5A H6PD HSD17B3 HSD11B1 HSD11B2 SRD5A2 CYP21A2 STAR BASE EXCISION REPAIR%WIKIPATHWAYS_20260211%WP4752%HOMO SAPIENS Base excision repair PARP2 POLE4 SMUG1 HMGB1-1 FEN1 MPG PNKP OGG1 UNG POLB POLD3 POLD4 NTHL1 POLD1 POLL POLE MUTYH MBD4 NEIL2 LIG1 PCNA APEX2 XRCC1 LIG3 NEIL3 POLE2 APEX1 POLE3 PARP1 TDG POLD2 IL19 SIGNALING%WIKIPATHWAYS_20260211%WP5422%HOMO SAPIENS IL19 signaling CXCR4 TGFB1 STAT3 ACTA2 COL1A1 MAPK8 STAT6 STAT1 CCNB1 IL4R IL4 TNF MAPK1 SOCS5 AKT1 TNFRSF1A MAPK3 MAPK14 CCL11 IL19 NFKB1 IL20RA IL20RB MUC5AC RAC1 SOCS1 JAK1 MMP1 G13 SIGNALING%WIKIPATHWAYS_20260211%WP524%HOMO SAPIENS G13 signaling CFL2 CFL1 MAPK10 PFN1 PIK3CD PIK3R2 PIK3CB SH3RF1 DIAPH1 WASL PIK3CA RHOA ROCK1 ROCK2 ARHGDIG MAP3K4 RPS6KB1 IQGAP1 TNK2 LIMK1 MYL1 PPP1CB CDC42 PKN1 RTKN IQGAP2 RHPN2 WAS MYBPH CIT ARHGDIB ARHGEF1 RAC1 CALM1 PAK3 CYFIP1 GNA13 PIP4K2A 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5400%HOMO SAPIENS 6q16 copy number variation BDNF GHRL NTRK2 AGRP NPY MC4R LEP POMC INS;INS-IGF2 LEPR GHSR SIM1 ARNT INSR CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260211%WP5193%HOMO SAPIENS Cholesterol synthesis disorders DHCR24 DHCR7 HSD3B1;HSD3B2 LBR SQLE IDI1 FDPS MVK HMGCR MSMO1 LSS HMGCS1-1 PMVK MVD FDFT1 EBP CYP51A1 SC5D METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260211%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus GALNT1 CERK B4GALT1 SGMS1 SGMS2 UGT8 UGCG SGPL1 KDSR CERS3 B4GALT2 SPHK2 B3GALNT1 SPHK1 GALNT16 SGPP2 SGPP1 B3GALT2 B3GALT1 B4GALNT1 ST6GALNAC3 T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer B2M TNFRSF4 CXCR4 HAVCR2 TGFB2 ENTPD1 TGFB1 TNFSF9 PDCD1LG2 TGFB3 VTCN1 TIGIT PDGFD HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TNFSF4 CD276 TNFRSF9 FAP FAS CTLA4 PDGFB SHH ARG1 PDGFC IL6 CCL17 CCL22 FASLG LGALS1 VDR CD86 CD40 NT5E CD80 CD40LG IL10 PDGFA VEGFA CD28 CXCL12 IL13 CD274 IL4 PDCD1 ICOS PGF IDO1 LGALS9C;LGALS9;LGALS9B VEGFB VEGFC CD226 VEGFD PVR VSIR LGALS3 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260211%WP438%HOMO SAPIENS Non homologous end joining POLL XRCC6 DCLRE1C PRKDC WRN XRCC4 POLM XRCC5 LIG4 NHEJ1 FRAGILE X SYNDROME%WIKIPATHWAYS_20260211%WP4549%HOMO SAPIENS Fragile X syndrome PTPN5 ALDH3A2 CLTC CLTA AP2A1 GAB1 EIF4A1 KCND2 GRB2 AP2M1 SOS1 CYFIP2 GRIP1 SH3GL1 GRIP2 TBC1D7;TBC1D7-LOC100130357 GRIA1 HOXB8 TELO2 ARHGAP32 ABCD3 KCNC1 TECR DNM1 DLGAP3 DNM2 TTI1 ALDH5A1 PICK1 EPS8L1 ARC PPP1CA DLG4 BDNF DICER1 AP2S1 GRIA2 AP2B1 HCN1 APP ARAF TARBP2 AGO2 CAMK4 CYFIP1 PDK1 FMR1 DUSP3 SYNGAP1 GAD1 SHANK1 GRIN2A RPTOR DEPTOR MLST8 MAPK1 AKT1 GABRB2 BRAF GABRD GABRA1 GRIN2B MKNK1 RPS6KB1 RHEB KRAS AKT1S1 NTRK2 PPP3CA SRC AGAP2 DAG1 GRM1 PLCB1 TSC2 TSC1 FYN PTPN11 PRKCA MAP2K2;MAP2K1 SHC1-1 SLC6A1 PRKAR1A GRIN1 MAP1B ITPR1 MMP9 CDKN2A EIF4E CNR1 EPHA4 PLCG1 RAF1 NF1 SLC16A1 PPP2R5B PTEN GRM5 EIF4EBP2 GPHN RAP1GAP GABRG3;GABRG2 PRKACA-1 EIF4G1 EEF1A1 PIK3CB ABAT CREB1 SH3GL3 CAMK2B MAP1LC3B2;MAP1LC3B-1 CAMK2A CLTB CPT1A MTOR CAMK1 AKAP5 HOMER1 CLTCL1 MECP2 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism DHCR24 DHCR7 LBR IDI1 FDPS MVK MSMO1 LSS HMGCS1-1 PMVK MVD SLC27A4 SAR1B MGAT1 CD36 ABCG8 ABCG5 FABP2 ACAT2 DGAT1 SQLE HSD17B7 TM7SF2 MTTP HMGCR APOA1 APOA4 NPC1L1 FDFT1 APOB LDLR EBP NSDHL CYP51A1 SC5D ABCA1 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260211%WP4707%HOMO SAPIENS Aspirin and miRNAs PPARA NOS3 MVD NFKB1 PTGS2-2 ABCC4 PDK1 WNT1 PTGS1 VEGFA 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260211%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation CRYL1 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260211%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis GRM8 STAT3 AP2A1 HDAC10 AP2A2 GRIP1 GRIA1 SLC32A1 GLUL DLGAP3 PICK1 FRMPD3 ARC ADARB1 SLC1A3 DLG4 ZFYVE27 SLC6A12 SLC1A7 EFNB2 NETO2 CPEB3 CRTC1 CABIN1 GABRR3 GRIA2 GRM3 GRIN3B GABRR1 GRIN3A NPTN GRIA3 C1QL3 MBD5 GRIA4 C1QL2 NWD1 AP2B1 SNX27 UBQLN4 CREBBP ATAD1 SYVN1 LHFPL4 SNX14 GABRR2 P4HB FFAR1 NRXN3 GAD1 STIM1 GRIN2A MAPK1 GABRB3 MAPK3 GABRB2 GABRB1 GABRE GABRD GABRQ PDIA2 SDCBP GABRA2 GRIN2C GABRA1 GRIN2B GABRP GRIN2D GNA11 SLC12A5 GABRA6 PPP2CB;PPP2CA GABRA5 GABRA4 GABRA3 GABRG1 SLC6A13 SLC6A11 SRC GRM1 PLCB1 SLC6A6 SLC6A8 PRKCA MAP2K2;MAP2K1 SLC6A1 GRIN1 NRG1 KIF5C GLS2 CDH2 GNAQ GRM5 GRM6 ERBB4 GRIK2 ORAI1 GABRG3;GABRG2 SUMO1 HDAC1 STAT1 GAPDH-1 ABAT SLC7A11 SLC1A2 SH3GL2 MAP1LC3B2;MAP1LC3B-1 NR4A1 CAMK2A CACNG8 CACNG2 SLC1A6 SLC1A1 HOMER1 GRIK5 GRIK3 GRIK4 GRIK1 GRM2 GRM4 GRM7 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260211%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ACO2 ACSS2 ALDH3A2 ALDH9A1 CS ALDH2 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer CCL13;CCL2 FCGR3A;FCGR3B PRF1 ADAM17 TIGIT GATA2 CCL5 CSF2 GZMH;GZMB-1 IFNG ADAM10 CD226 MYC CD96 NCR1-1 TNF BMI1 CCL4L2;CCL4L1;CCL4 NCR3LG1-1 KLRC4-KLRK1;KLRK1 PVR CCL3L1;CCL3L3;CCL3;CCL18 FOXO1-1 CCL1 COPPER METABOLISM%WIKIPATHWAYS_20260211%WP5189%HOMO SAPIENS Copper metabolism SLC11A2 ATP7B SLC31A1 ATP7A MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAP3K12 MAP2K2;MAP2K1 MAPK10 MAPK9 MAPK8 PARP14 ATF4 TNKS MAPK1 MAP3K1 MAPK3 MAP2K6 BRAF MAP3K5 MAPK14 MAP3K9 DUSP1 MAP2K3 MAP2K4 MAPK12 RAF1 MAPK13 MAPK11 MAP3K10 MAP3K11 PARP1 MAP3K8 ARAF MAP3K7 MAP2K7 MAP3K21 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment CSF2RA CXCR4 LAG3 CD80 CCR5 TGFB1 CSF1R CSF2 KDR VEGFA CXCL12 BAG3 FAS CSF1 CTLA4 CXCL10 CCR2 NRP1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CCL13;CCL2 CXCR3 CCL5 ITGB6 HLA-DRA FASLG IFITM3;IFITM2;IFITM1 CD86 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome ACTR1B KIAA0753 BMERB1 DCP2-1 GATA3 DISC1 OFD1-1 NDE1 ABCC6 MARF1 CEP20 DCP1A ACTR10 RAPGEF4 RAP1A PAFAH1B1 DCTN1 PLAGL1 PLK1 PLAG1 ACTR1A MYH11 DCTN6 DCTN4 ABCC1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260211%WP1584%HOMO SAPIENS Type II diabetes mellitus MAFA CACNA1A IKBKB SLC2A4 MTOR MAPK8 SURF1 KCNJ11 GK PHKA2 SLC2A2 SOCS4 INS;INS-IGF2 IRS1 PRKCZ TNF MAPK1 PIK3R5 INSR PDX1 ADIPOQ FOXP3 IN COVID 19%WIKIPATHWAYS_20260211%WP5063%HOMO SAPIENS FOXP3 in COVID 19 STAT5A STAT5B CD80 STAT3 IL2RG IL2RA IL2RB IL6R IL6 CD28 IL6ST FOXP3 IL2 IL7R CD86 CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260211%WP4562%HOMO SAPIENS Canonical NF kB pathway NFKBIA CHUK REL IKBKG NFKB1 IKBKB NFKBIE RELA ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260211%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer TP53 CCNE2 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260211%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 LRP1 SEL1L APOA5 LMF1 ANGPTL4 LPL CETP APOA2 APOA1 LCAT APOA4 ANGPTL8 ANGPTL3 LIPC APOC2 LDLR PLTP GPIHBP1 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260211%WP2290%HOMO SAPIENS RalA downstream regulated genes EXOC8 RAC3 RALA-1 RALBP1-1 NRAS YBX3 KRAS RAC1 EXOC2 HRAS CDC42 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260211%WP363%HOMO SAPIENS Wnt signaling NetPath PRKCB ARRB2 PIP5K1B PRKCA TPTEP2-CSNK1E;CSNK1E GSK3B MAPK9 MAPK8 CSNK1A1 CTNNB1 AXIN1 SOX1 RYK-1 ROR1 PI4K2A MAPK1 CTBP1 AKT1 RHOA BCL9 NFATC2 LRP5 NLK LRP6 ROR2 LEF1 MTOR CSNK1G1 APC GSK3A CDK6 TCF7L2 TCF4 CCND1 PPARG MAP3K7 DVL1 RAC1 DVL2 DVL3 PRKCG TSC2 TSC1 CSNK1D GCKR ATR SIGNALING%WIKIPATHWAYS_20260211%WP3875%HOMO SAPIENS ATR signaling RPA2 RAD1 RPA3 CHEK1 RAD9A RPA1 HUS1 TOPBP1 RAD9B ATR ATRIP MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260211%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis THBS2 BCAR1 TEAD1 FN1 TEAD2 TEAD3 COL1A1 SNAI2 PBX3 COL3A1 COL5A1 TEAD4 EDNRA YAP1-1 GPC6 SPARC NRF2 PATHWAY%WIKIPATHWAYS_20260211%WP2884%HOMO SAPIENS NRF2 pathway TGFB2 TGFB1 GCLM SOD3 ABCC5 SLC6A4 HSPA1A;HSPA1B SERPINA1 GSTM1;GSTM2-1 GSTA3;GSTA1 GSTA3;GSTA5;GSTA1;GSTA2 KEAP1 MAFG UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 EPHA2 SLC6A17 SLC6A16 SLC6A15 SLC6A14 SQSTM1 SLC6A13 SLC6A11 SLC5A6 SLC5A7 SLC5A9 CES3 EPHA3 MGST3 MGST2 SLC5A3 SLC5A4 PRDX1 GSTM3 GSTM4 PRDX6 SLC6A5 SLC6A6 SLC6A7 SLC6A8 SLC6A9 SLC6A1 SLC6A2 HGF SLC2A11 NRG1 SLC2A10 SLC2A13 SLC2A12 SLC39A11 SLC39A10 SLC39A13 PDGFB TGFA FGF13 SLC39A12 HSP90AB1 SLC6A3 HBEGF CES2 GSTP1 CES1 HSP90AA1 CBR3 AGER PTGR1-1 MAFF TXN RXRA GSTA4 GGT1 CBR1-1 G6PD SLC39A9 GSR SLC39A6 SLC39A5 PPARD SLC39A7 TGFBR2 SLC39A2 SLC39A1 GCLC SLC39A4 SLC39A3 PGD ALDH3A1 NFE2L2 CYP2A13;CYP2A6;CYP2A7-1 CES5A SLC2A4 SLC2A9 SRXN1 SLC2A5 SLC2A1 SLC2A6 SLC2A2 SLC2A7 SLC2A8 SLC7A11 ME1 ABCC4 FTH1 SLC39A8 SLC6A19 BLVRB ABCC2 SLC6A18 SLC5A11 SLC5A1-1 SLC5A12 SLC5A10 SLC5A8 TXNRD3 SLC39A14 DNAJB1 NQO1 UGT1A1;UGT1A6 GSTT2B;GSTT2 ABCC3 HMOX1 EGR1 SLC5A2 SLC6A20 SLC5A5 FTL-1 TXNRD1 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260211%WP5120%HOMO SAPIENS Inclusion body myositis BACE1 SIRT1 APP NFKB2 NFKB1 PSEN2 MAPT NCSTN MSTN PSENEN PSEN1 ID SIGNALING%WIKIPATHWAYS_20260211%WP53%HOMO SAPIENS ID signaling SREBF1 ID3 CDK2 ID2-1 CCNE1 MYOD1 ID1 PAX2 RB1 RBL2 RBL1 PAX8 ELK4 ELK1 PAX5 ELK3 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260211%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGM PGAP3 PIGW PIGS PIGU PIGT PGAP1 PIGO PGAP2 PIGX-1 PIGN PIGV GPAA1 PIGQ PIGP PIGC DPM2 PIGB PIGA PIGK PIGL MPPE1 PIGG PIGF PIGH CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260211%WP2029%HOMO SAPIENS Cell differentiation index STAT3 SRF TLX2 LEFTY2;LEFTY1 TLX3 HDAC5 TLX1 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260211%WP167%HOMO SAPIENS Eicosanoid synthesis LTA4H ALOX15B DPEP1 ALOX5AP PTGS2-2 ALOX15 PLA2G5 PLA2G6 PTGS1 JMJD7-PLA2G4B;PLA2G4B PTGDS PTGIS PLA2G4A GGT1 CBR1-1 PRXL2B ALOX12 TBXAS1 LTC4S PTGES2 PTGES ALOX5 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP3941%HOMO SAPIENS Oxidative damage response CYCS-1 BCL2 C2 CDKN1C MAPK10 LOC110384692;C4A;C4B_2;C4B BAK1 CASP9 CASP3 APAF1 TRAF1 TRAF2 CDKN1A C1QC TNF C3AR1 MAP3K1 TRAF3 CR2 GADD45A TRAF6 MAP3K9 MAP2K4 PCNA MAPK13 NFKB1 BAD TNK2 C1S CDC42 TNFRSF1B C1R C5AR1 BAG4 TDP2 NFKBIE CDKN1B C5 C1QB HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260211%WP4540%HOMO SAPIENS Hippo signaling regulation PRKCB FGFR1 PRKCE LATS2 PRKCD TEAD1 PRKCA TEAD2 CSF1R TEAD3 GNAS-1 CDH7 KDR PRKAR1B PDGFRB PRKAR1A SMAD2;SMAD3 PDGFRA PRKCQ FGFR3 CTNNB1 CDH9 CDH8 FGFR4 CDH4 MET CDH3 PRKCZ CDH20 CDH22 CDH24 PRKAR2B WWTR1 CDH10 CDH11 PRKAR2A CDH12 CDH13 FLT4 CDH15 CDH6 CDH17 FGFR2 CDH2 CDH1 CDH19 CDH18 LEF1 TCF7 CDH16 GNAQ NF2 PRKD3 TCF7L2 TCF7L1 GNAI3 RAC1 GNAI2 EGFR PRKACA-1 PRKAG1 PRKAG2 PRKCI PRKAA2 FLT1 PRKAG3 TEK IGF1R PLCB3 NGFR PRKAB2 PRKAB1 FLT3 CDH5 RHOA INSR EPHA2 YAP1-1 PRKAA1 GNA11 MST1 NTRK1 NTRK2 KIT PRKACB-1 MTOR CDC42 PLCB4 GNAL TEAD4 PRKCG PLCB1 PLCB2 PRKCH STK3 LATS1 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer NOTUM CSNK1A1 WNT7B WNT7A CHD8 ATF3 CTNNB1 CTBP2 CCND2 NKD1 NKD2 CTBP1 SOST RUVBL1 SFRP1 WNT5B WNT5A FOSL1 JUN PLAU LEF1 TCF7 TCF7L2 TCF7L1 WNT6 FZD10 DVL1 FRAT2 DVL2 CSNK2A2 DVL3 SFRP2 DKK1 DKK2 WNT1 CCND3 DKK4 WNT2 EZH2 SFRP4 WNT3 WNT4 CSNK2B WNT3A TPTEP2-CSNK1E;CSNK1E GSK3B WNT2B TFAP2A SOX17 AXIN1 FZD1 RYK-1 WNT10B MYC CER1 ROR1 WNT10A AXIN2 FZD3 WNT16 FZD2 FZD5 FZD7 WIF1 FZD6 FZD9 FZD8 LRP5 HNRNPU ROR2 NLK LRP6 WNT11 APC SERPINF1 APC2 CDK6 CCND1 MAP3K7 CTNNBIP1 KREMEN1 SENP2 SFRP5 CSNK2A1;CSNK2A3 MACROH2A2 CXXC4 PORCN CDK8 HNRNPK IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260211%WP5172%HOMO SAPIENS Iron metabolism disorders HFE CYBRD1 SLC11A2 SLC40A1 HEPH HJV TFR2 BCS1L TF UQCRFS1 STEAP3 HAMP FTL-1 FTH1 TFRC CP ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260211%WP3878%HOMO SAPIENS ATM signaling in development and disease PPP5C NBN PPM1D CDC25A RBBP8 SMC1A CDK5 IKBKG RNF20 ATMIN-1 RNF40 CEP63 HMGN1 NHEJ1 RAD50 MDC1 DCLRE1C HSPB1 RIF1 KAT5 TRIM28 HDAC4 RNF168-1 RNF8 TP53BP1 MAPK14 BUB1 CDK2 PPP2CB;PPP2CA MAPK12 ATF2 MAPK13 ATM NFKB1 MAPK11 MTOR ATR MRE11 LMNB2 TP53 STK11 CHEK2 PRKDC CHEK1 G6PD AURKB TSC2 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260211%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY1 ADORA1 LPAR4 LPAR6 ADORA2A ADORA2B P2RY6 P2RY4 P2RY2 LTB4R ADORA3 SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260211%WP615%HOMO SAPIENS Senescence and autophagy in cancer ING2 TGFB1 FN1 GSN COL1A1 SMAD2;SMAD3 IL6ST IGFBP7 MAP2K3 PLAU MMP14 BMP2 BMI1 ATG14 ATG13 KMT2A CEBPB ULK1 IL6R IFNG LAMP2 IGF1R MLST8 INS;INS-IGF2 CDKN1A IFNB1-4 ATG3 MAPK1 GABARAPL2 BRAF SPARC IGF1 ATG12-1 ATG16L1 AKT1S1 SQSTM1 RB1 HRAS IL1A SRC COL3A1 IGFBP5 IGFBP3 CDC25B MAP2K2;MAP2K1 MDM2-2 IRF1 LAMP1 FKBP8 SERPINB2 GABARAP TNFSF15 ING1 COL10A1 RNASEL IFI16 CREG1 RSL1D1 CXCL2;CXCL3;CXCL1-1 CXCL14 IRF7 CCL3L1;CCL3L3;CCL3;CCL18 CDKN2A IRF5 SMAD4 RAF1 JUN IL24 CD44 IL6 PTEN THBS1 SH3GLB1 VTN UVRAG CDKN1B ATG10 SLC39A2 SLC39A1 SLC39A4 SLC39A3 BCL2 INHBA GSK3B E2F1 RB1CC1 IL1B CXCL8 MAP1LC3A MAP1LC3C PIK3C3 MAP1LC3B2;MAP1LC3B-1 BECN1 MAPK14 IL3 AMBRA1 PCNA SERPINE1 MTOR PLAT TP53 ATG7 ATG5 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP69%HOMO SAPIENS T cell receptor signaling NFKBIA PRKCD MAP2K2;MAP2K1 SH2B3 SHC1-1 CD4 MAPK9 MAP4K1 MAPK8 PDPK1 PRKCQ GRB2 SOS1 ITPR1 ITK PSTPIP1 DBNL RIPK2 FYB1 PLCG1 GRAP2 RAF1 JUN NFKB1 LCP2 CARD11 BCL10 MALT1 LAT WAS REL IKBKG PAK1 PIK3R2 PIK3R1 CD3G FOS CD28 CD247 CD3E CD3D CHUK NFATC1 MAP3K14 CREB1 MAPK1 AKT1 CRKL MAPK3 ICOS TRAF6 CRK MAPK14 NFATC2 PTK2B ATF2 LCK IKBKB CD8A HRAS GAB2 CBLB CDC42 VAV1 NCK1 VAV3 ZAP70 MAP3K8 SKAP1 MAP3K7 CBL FYN RELA PTPN11 METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260211%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts FGFR1 PHGDH PYCR1 GCK GLUD1;GLUD2 P4HA2 SLC2A1 GLS ALDH18A1 LPAR1 FGFR4 LOXL2 PGM1 RHOA CD36 PLOD1 BMP1 ADAMTS2 UGP2 GPI P3H4 P3H3 UGDH P4HA1 PLCG1 P4HA3 SLC16A1 SLC1A5 PSPH LDHA SERPINH1 PSAT1 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260211%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs PNPLA2 PC GAPDH-1 GK LIPE AKR1A1 ALDOA GPD2 SDS PFKL AGXT GPI AQP9 KHK PKLR GLYCTK GRHPR GPD1 ALDOB FBP1 G6PC1 LOC100509620;LOC112267859;AQP7 PCK1 PGK1 TPI1 ENO1 PGAM1 HK1 MGLL OXYTOCIN SIGNALING%WIKIPATHWAYS_20260211%WP2889%HOMO SAPIENS Oxytocin signaling CD38 OXTR PLCD1 GNAQ PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway CYCS-1 UBE2G2 SNCAIP CASP7 CASP2 PARK7 CCNE2 UBA1 HTRA2 CASP9 TH EPRS1 CASP3 UBE2L6 APAF1 LRRK2 UBB;UBC MAPK14 PINK1 SLC6A3 GPR37 ATXN2 MAPK12 MAPK13 CCNE1 MAPK11 PRKN DDC UBA7 UCHL1 SYT11 UBE2J2 UBE2J1 SNCA CASP6 SEPTIN5 UBE2G1 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer IL25 TGFB2 TGFB1 TGFB3 IL12B IL12A CSF2 IFNG IL10 IL23A VEGFA CXCL12 IL17F IL13 IL17D IL17C IL2 IL17B IL4 IL1B IL5 IL17A CXCL8 TNF CXCL2;CXCL3;CXCL1-1 MMP9 CXCL5;CXCL6 CCL13;CCL2 CCL5 IL6 LGALS9C;LGALS9;LGALS9B CCL20 REG4 VEGFB CCL28 VEGFC VEGFD LGALS1 LGALS3 SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260211%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders TEAD2 YES1 H4-16 FGF4 SRRT SOX12 POU3F1 UTF1 SOX2 SOX15 ZSCAN10 SOX4 H4C1 SOX11 POU3F2 H4C6 WWTR1 DNA MISMATCH REPAIR%WIKIPATHWAYS_20260211%WP531%HOMO SAPIENS DNA mismatch repair POLD1 RFC2 POLE RFC1 POLE4 LIG1 PCNA MSH6 POLE2 MSH2 POLE3 RFC3 RFC4 MLH1 RPA2 EXO1 RPA3 PMS2 RPA1 POLD3 POLD4 POLD2 RFC5 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260211%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria UQCRB UQCR11 UQCR10 UQCRQ UQCRC1 UQCRFS1 UQCRC2 SDHC SDHD SDHB NDUFV1 SDHA COX7C NDUFS8 NDUFS3 COX5A NDUFA9 NDUFA4 NDUFA11 NDUFA12 NDUFA10 COX6A2 ATP5IF1 NDUFC1 NDUFS7 SCO1 NDUFS6 NDUFS4 NDUFS2 NDUFS1 SLC25A14 NDUFB9 NDUFB8 NDUFB7 COX7A2L-1 NDUFB10 NDUFB6 NDUFB5 COX15 NDUFB4 SURF1 NDUFB3 COX17 ATP5MC2 COX6A1 NDUFB2 NDUFB1 ATP5MC3 COX7A2 COX6B1 ATP5MC1 NDUFA13 SLC25A27 ATP5F1A ATP5F1B NDUFC2;NDUFC2-KCTD14 UCP3 SLC25A5 UCP2 SLC25A4 COX11 SLC25A6 NDUFV3 COX7B NDUFV2 ATP5MG COX4I1 ATP5ME DMAC2L NDUFA8 ATP5PF NDUFA7 NDUFA6 ATP5PD COX8A NDUFA5 ATP5PB NDUFA3 ATP5F1C ATP5F1D NDUFAB1 ATP5PO NDUFS5-1 COX5B COX6C UCP1 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260211%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms TEAD1 TEAD2 TEAD3 ACTA2 PAK1 YWHAQ MAPK10 SGMS1 MAPK9 MAPK8 MAP4K1 MAP4K2 ITGB3 ACTA1 CTNNB1 MAP4K5 MAP4K3 MAP4K4 YAP1-1 WWTR1 PAK2 ITGB5 ITGB2 ITGB4 ITGB1 MST1 CDH1 ITGB8 ITGB6 NF2 ITGB7 ACTB-1 LIMD1 ACTG1 BUB1B-PAK6;PAK6 SRC SAV1 TEAD4 CTNNA1 PAK3 PAK5 PAK4 STK3 ACTC1;ACTG2 LATS1 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP560%HOMO SAPIENS TGF beta receptor signaling SKI TGFB1 SKIL STAT3 NOG ZFYVE9 MAPK9 LTBP1 SMAD2;SMAD3 ZNF423 ENG BAMBI CTNNB1 TGIF1-1 TNF SMAD1 SMAD5 ZEB2 BMP4 SMAD6 SMAD4 EGF RUNX2 JUN NFKB1 LEF1 ITGB6 LIF CREBBP TFE3 THBS1 JAK1 EP300 TGFBR2 WNT1 SPP1 FST INHBA FOXH1 STAT1 IFNG FOS TGFBR1-1 FKBP1A LEFTY2;LEFTY1 TGFBR3 MAPK3 SMAD7 SERPINE1 HRAS RUNX3 SMAD9 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260211%WP4262%HOMO SAPIENS Breast cancer pathway NFKB2 GRB2 SOS1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 PIK3R3 FGF10 LEF1 TCF7 HES1 HES5 TCF7L2 TCF7L1 ARAF FZD10 FRAT2 CSNK2A2 SFRP4 CSNK2B E2F2 SKP1 PIK3R2 PIK3R1 IGF1R FZD1 AKT2 WNT10B CDKN1A MYC WNT10A AKT3 FZD3 MAPK1 AKT1 FZD2 FZD5 MAPK3 FZD7 FZD6 BRAF FZD9 IGF1 FZD8 BAX CDK4 RPS6KB1 KRAS TNFSF11 KIT RB1 FGF1 HRAS MRE11 FGF3 FGF4 APC2 FGF5 FGF6 FGF7 FGF8 FGF9 CCND1 JAG2 CSNK2A1;CSNK2A3 ERBB2 FGF18 FGFR1 FGF23 NRAS MAP2K2;MAP2K1 SHC1-1 HEY1 HEY2 FGF20 DLL1 CSNK1A1 FGF22 NCOA1 DLL3 WNT7B FGF21 DLL4 WNT7A FGF17 FGF16 CTNNB1 SOS2 SHC4 FGF19 SHC2 SHC3 GADD45A ESR1 WNT5B WNT5A EGF FLT4 RPS6KB2 RAF1 JUN ATM SP1 ATR PTEN WNT6 BRCA1 BRCA2 DVL1 DVL2 DVL3 NCOA3 ESR2 WNT1 WNT2 WNT3 WNT4 WNT3A NBN PGR EGFR DDB2 GSK3B WNT2B E2F1 PIK3CD BAK1 FOS GADD45B RAD50 GADD45G AXIN1 RAD51 AXIN2 POLK WNT16 PIK3CA LRP5 LRP6 WNT11 MTOR APC CDK6 E2F3 TP53 CETN3 HEYL PARP1 FGF2 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260211%WP4331%HOMO SAPIENS Neovascularization processes CXCR4 EPHB2 TGFB2 TGFB1 REL RELB TGFB3 NFKB2 ANGPT1 MAPK9 MAPK8 KDR SMAD2;SMAD3 DLL4 TGFBR1-1 CXCL12 NOTCH3 NOTCH1 NOTCH4 MAPK1 SMAD1 AKT1 MMP9 MAPK3 PDGFB SMAD5 HIF1A FLT4 NFKB1 KIT EPHB4 ACVRL1 KITLG JAG1 SMAD9 RELA CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260211%WP5603%HOMO SAPIENS Caffeine in myocytes MYH7 RYR3 ACTA2 MYL2 TNNI1 ACTA1 MYH6 MYH11 MYL1 TNNC1 ACTB-1 ACTG1 MYLPF MYH13 TNNI2 TNNI3 TNNC2 TPM4 MYH1 TPM3 MYL6 TPM2 MYH3 RYR1 TPM1 TNNT1 TNNT2 RYR2 TNNT3 ACTC1;ACTG2 MYL3 MYH8 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260211%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine ASMT DNAJC12 AANAT PTS QDPR SPR PAH MAOB DHFR2;DHFR PNMT TH MAOA DBH COMT GCH1 NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway NFKBIA NFKBIB DHX58 TRIM25 MAPK10 AZI2 DDX17 MAPK9 SIKE1 MAPK8 RNF125 IFNE TKFC CYLD PIN1 TNF CASP8 MAP3K1 CXCL10 IRF7 TBKBP1 ISG15 MAPK12 MAPK13 NFKB1 IFNK MAPK11 TRADD CASP10 DDX3X-1 RIPK1 TANK IKBKE TBK1 OTUD5 IKBKG DDX58 IFIH1 IFNG STING1 IRF3 CXCL12 CHUK FADD SNW1 MAVS TRAF2 IFNB1-4 CXCL8 TRAF3 TRAF6 NLRX1 MAPK14 ATG12-1 IKBKB MAP3K7 ATG5 RELA CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes SREBF1 DHCR24 LBR NR1H2 CH25H IDI1 FDPS MVK IDI2 MSMO1 ELOVL5 LSS PLPP6 HMGCS1-1 PMVK MVD HMGCS2 SCD CYP7A1 NR1H3 ACAT2 ACSL1 HSD17B7 TM7SF2 ACSL3 GGPS1 ACOT2;ACOT1 ELOVL4 ELOVL3 ABCG1 HMGCR FADS2 MYLIP FDFT1 EBP NSDHL CYP46A1 ELOVL2 CYP51A1 SC5D ABCA1 CYP27A1 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260211%WP623%HOMO SAPIENS Oxidative phosphorylation ATP6AP2 NDUFA4L2 NDUFV1 NDUFS8 NDUFS3 NDUFA9 NDUFA4 ATP6AP1 NDUFA11 NDUFA10 NDUFC1 NDUFS7 NDUFS6 NDUFS4 NDUFS2 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 ATP5MC2 NDUFB2 NDUFB1 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 ATP5MG ATP5ME DMAC2L NDUFA8 ATP5PF NDUFA7 NDUFA6 ATP5PD NDUFA5 ATP5PB GZMH;GZMB-1 NDUFA3 ATP5F1D NDUFAB1 ATP5PO NDUFS5-1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260211%WP2253%HOMO SAPIENS Pilocytic astrocytoma NRAS KRAS NF1 RAF1 BRAF HRAS GRB2 PTPN11 SOS1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260211%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling NFKBIA BCL2 MAP2K2;MAP2K1 IKBKG GSK3B AR PDGFRB MDM2-2 CASP9 GRB2 PDGFA SOS1 CTNNB1 KLK3;KLK2 CDKN1A AKT3 CREB3L1 MAPK1 PIK3CA FOXO1-1 KRAS RAF1 NFKB1 BAD TCF7 MTOR TP53 CREBBP CCND1 CDKN1B PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies IL22 CCR6 IL23R STAT3 TYK2 IL12B HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E JAK2 IL12RB1 IL23A CCL20 IL17F IL1B IL17RC IL17A CXCL8 CXCL2;CXCL3;CXCL1-1 TNF AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260211%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction MYLK CD38 PPP1R14A MYL1 PPP1CB GNAQ GDI1 IL13 ITPR3 CALM1 RYR1 RHOA PLCB1 ADRB2 ROCK1 ROCK2 OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260211%WP1434%HOMO SAPIENS Osteopontin signaling SPP1 MAP2K2;MAP2K1 NFKB1 PLAU IKBKB ITGAV ITGB3 CHUK MAP3K14 MAPK1 MMP9 MAPK3 RELA HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260211%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy ATG12-1 ULK2 ATG16L1 ULK1 PIK3R4 ATG4A MTOR RB1CC1 WIPI1 ZFYVE1 ATG16L2 ATG3 ATG7 MAP1LC3A ATG5 PIK3C3 ATG10 ATG13 BECN1 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260211%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport HSD3B7 CYP7B1 AMACR SLC27A2 SLC51A SLC51B HSD17B4 ABCD3 ATP8B1 ABCC4 BAAT CYP7A1 ABCC2 SCP2 ABCB1 ABCC3 CYP8B1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB4 FABP6 SLC27A5 SLC10A1 SLC10A2 ABCB11 ACOX2 AKR1D1 CYP27A1 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP496%HOMO SAPIENS Steroid biosynthesis HSD3B1;HSD3B2 HSD17B3 F13B HSD17B7 HSD17B4 HSD17B1 CPN1 CYP17A1 HSD17B2 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260211%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PTK2 LATS2 TEAD1 TEAD2 TEAD3 PIK3CD PIK3R2 PIK3R1 PIK3CB PLCB3 AKT2 AKT3 MAPK1 AKT1 PIK3R3 PIK3CA RHOA YAP1-1 ROCK1 PKN2 MTOR PKN3 GNAQ PKN1 TRIO PLCB4 MOB1A;MOB1B TEAD4 PLCB1 TSC2 PLCB2 TSC1 LATS1 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2542%HOMO SAPIENS Sulindac metabolic pathway FMO3 MSRA CYP1A2 MSRB2 CYP1B1 MSRB3 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260211%WP2197%HOMO SAPIENS Endothelin pathways ATP2A2 ADRB1 MYLK MAP2K2;MAP2K1 PRKCA GNAS-1 NPY ADRA1A CALCA EDN1 MAPK1 CALCRL ECE1 CNN1 EDNRB GNAI1 NPY1R RIIAD1 CAD ADCY10 RAF1 GNG13 MYL1 NOS3 PTGIR GNB5 CALM1 RAMP1 EDNRA PLCB1 GNA15 LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma FH CS TFE3 NMRK2 NONO SLC19A2 MDH2 HSPE1 SIGNALING LIPIDS%WIKIPATHWAYS_20260211%WP5584%HOMO SAPIENS Signaling lipids CYP7B1 CYP2B6 PTGS2-2 CYP2C9;CYP2C19 ALOX12 LTC4S ALOX5 CYP7A1 LTA4H GPX4 PLA2G1B HPGD ALOX15 EPHX2 FADS2 PTGDS CYP8B1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 PRXL2B TBXAS1 PLCB1 PTGES PLA1A CYP27A1 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260211%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism RDH12 AWAT2 LRAT BCO1 SULT2B1 CYP26A1 ADH1C;ADH1B;ADH1A CYP26B1 RARB MAPK1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 RXRB CD36 RXRG ABCG8 ABCG5 RDH8 CRABP2 DGAT1 RARA RETSAT CRABP1 BCO2 DHRS3 ALDH1A2 RBP7 ALDH1A1 RBP4 SCARB1 RBP2 RBP1 LPL RDH5 CYP2E1 ADH4 RXRA NPC1L1 RARG RDH10 RPE65 RLBP1 SDR16C5 ALDH1A3 GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism FUT1 ST8SIA1 ST8SIA3 SLC33A1 B3GALT4 ST3GAL5 ST8SIA5 A3GALT2 ST3GAL1 ST3GAL2 ST6GALNAC6 B3GALT1 B4GALNT1 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway COMT EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260211%WP3930%HOMO SAPIENS EDA signaling in hair follicle development WNT3 RELB EDAR GLI1 PTCH1 EDARADD LTB SOSTDC1 DKK1 SHH BMP1 EDA DKK4 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260211%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GNRH1 GHRH SST IGF1 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260211%WP5178%HOMO SAPIENS Disorders of fructose metabolism GPI SLC5A1-1 SORD KHK ALDH1A1 GLYCTK ALDOB FBP1 SLC2A2 G6PC1 TPI1 HK1 PGM1 PFKL DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP707%HOMO SAPIENS DNA damage response CYCS-1 CDC25A BID MDM2-2 FAS CCND2 ABL1 CASP8 GADD45A SFN CCNE1 ATM ATR BRCA1 FANCD2 CDKN1B HUS1B BBC3 PIDD1 CCND3 SESN1 TLK2 TLK1 NBN RFC1 SMC1A CDK5 CDC25C DDB2 CCNE2 RRM2B E2F1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CCNB3 CCNB2 CASP9 CCNB1 PMAIP1 PML ATRIP CASP3 GADD45B RPA2 RAD50 APAF1 GADD45G RAD52 RAD51 CREB1 CDKN1A CDK1 MYC RAD17 RAD1 RAD9A AKT1 BAX CDK4 CDK2 RB1 MRE11 CDK6 TP53 CCND1 CHEK2 PRKDC CHEK1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260211%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients TGFBR1-1 ATG16L1 PMEPA1 LDLRAD4 NEDD4 SMAD2;SMAD3 TGFBR2 MRNA PROCESSING%WIKIPATHWAYS_20260211%WP411%HOMO SAPIENS mRNA processing HNRNPD SRP54 NCBP1 DICER1 DHX15 NCBP2-1 PRPF40A PPM1G YBX1 U2AF1L5;U2AF1 HNRNPR EFTUD2 SNRPD2 SNRPD1 HNRNPH1 CLP1 PAPOLA SNRPD3 TXNL4A PSKH1 SNRPN PRPF4B CDC40 SRRM1 PRPF4 PRPF6 PRPF3 XRN2 NONO SRSF2 SRSF3 CD2BP2 SNRPF SREK1 SRPK1 SRSF5 SRSF6 SRSF7 SNRPA SNRPB SFPQ-1 DHX8 CSTF3 CSTF2 SNU13 PRPF8 DHX38 SNRPE-2 CPSF4 CPSF1 TMED10 CPSF3 CLK4 DDX1 CLK3 LSM2 CLK2 HNRNPL CLK1 SPOP LSM7 RNPS1 CLASRP HNRNPC SUGP2 SUGP1 CELF1 CELF2 CELF4 SNRNP70 DHX16 RBM5 RBM17 CPSF2-1 PRMT2 PRMT1 PRPF18 SNRPA1 HNRNPH2 DNAJC8 HNRNPA1-1 RBM39 SF3B5 SF3B4 SF3B2 SF3B3 SFSWAP SRSF1 HNRNPK DDX20 HNRNPM CSTF2T NXF1 POLR2A U2AF2 TRA2B SNRPB2 SNRPG-2 SF3B1 SF3A3 SF3A1 SRSF4-1 RNGTT SF3A2 HNRNPAB NUDT21 SNRNP40 PHF5A HNRNPA2B1 PABPN1-1 RBMX SRSF10 FUS RNMT SRSF9 SMC1A SRPK2 PTBP1 PTBP2 SUPT5H HNRNPU METTL3 DHX9 PCBP2 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260211%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation NFKBIA IKBKG IL12B IL12A PIK3CD PLCD3 PLCD4 PIK3CB CHUK PLCB3 ITPR1 RETN AKT2 AKT3 CXCL8 TNF MAPK1 AKT1 MAPK3 PIK3CA PLCE1 MAPK14 PLCG2 PLCG1 PIK3CG NFKB1 IKBKB IL6 PLCB4 PLCB1 PLCD1 PLCB2 RELA LUNG FIBROSIS%WIKIPATHWAYS_20260211%WP3624%HOMO SAPIENS Lung fibrosis TGFB1 SKIL SFTPC CCN2 HGF ELMOD2 CALCA FAM13A MT2A CYSLTR2 TNF CXCL2;CXCL3;CXCL1-1 ATP11A BMP7 MMP9 RTEL1 PARN PDGFB DPP9 TGFA STN1 CCL3L1;CCL3L3;CCL3;CCL18 CMA1 CCR2 MUC5B CCL13;CCL2 EGF CCL11 SERPINA1 MMP2 PLAU CCL5 IL6 CCL4L2;CCL4L1;CCL4 CEBPB SPP1 NFE2L2 IL12B CSF2 PDGFA PTX3 IL13 GREM1 IL1B IL4 EDN1 IL5 CXCL8 CCR3 IGF1 SMAD7 FGF1 TIMP1 DSP FGF7 HMOX1 CSF3 TERT FGF2 MECP2 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260211%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis GCK SLC2A4 GOT1-1 PC GAPDH-1 SLC2A5 SLC2A1 SLC2A2 ALDOA HK3 PFKL PFKM ENO2 GPI ENO3 HK2 MPC2 PGAM2 PKM FBP2 DLAT LDHAL6B PKLR DLD GOT2-1 ALDOB FBP1 LDHB G6PC1 LDHA;LDHC LDHA PCK1 MPC1 PGK1 TPI1 ALDOC ENO1 PGAM1 HK1 PFKP PDHA1 MDH1 MDH2 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260211%WP5166%HOMO SAPIENS Glyoxylate metabolism SLC26A1 LDHA PXMP2 DAO HAO1 HOGA1 ALDH4A1 GRHPR PRODH2 GOT2-1 AGXT WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260211%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates HK2 U2AF2 OTUB2 VHL USP37 MTOR KDR USP7 FBP1 USP44 USP28 VEGFA OTUD6B SLC2A1 OTUD7B G6PC1 LDHA MYC PGK1 AKT1 PGAM1 PIK3CA HIF1A FOXO1-1 ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260211%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development DDIT3 KCNQ2 CSNK2B SNAP25 EIF2A ATF6 DNM1L SCN2A SPTBN4 ANK3 BRSK1 BRSK2 ATF4 SEMA3A ANK2 PRICKLE1 L1CAM SPTAN1 MAPT CSNK2A2 CSNK2A1;CSNK2A3 EIF2AK3 SCN5A PRRT2 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260211%WP2333%HOMO SAPIENS Trans sulfuration pathway CTH MAT2B GCLM DNMT1 AHCY CSAD CBS;CBSL MPST GOT1-1 MTR-1 METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases SCARB1 LPL MTTP CETP ANXA2 APOA2 PCSK9 APOA1 APOE LCAT LIPG LIPC APOB LDLRAP1 APOC2 LDLR ABCA1 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260211%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer PTK2 CASP7 F2R JUND HSPD1 NRG1 ABL1 TNF RIPK2 IL7R ERBB3 PAK2 ERN1 NFKB1 VIM BIRC5 CUL1 APP ETS1 THBS1 SERBP1-1 HSPA5 IER3 BCL3 HELLS CTNNA1 CDKN1B CARD14 TNFRSF21 BEX3 RNF7 NET1 GCLC CUL5 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A HDAC1 ANXA5 TRAF1 HSPB1 YBX3 AXIN1 APOE CDKN1A MAPK1 AKT1 SMAD7 RPS6KB1 PTK2B NQO1 SQSTM1 PKN1 VAV3 SOCS3 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation DCTN3 NDEL1 PPP2CB;PPP2CA CDK5 DISC1 YWHAQ DDC YWHAG TH YWHAH DCTN6 DCTN5 DBH YWHAZ DCTN2 DCTN4 PAFAH1B1 DYNC1H1 DCTN1 YWHAE YWHAB REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260211%WP51%HOMO SAPIENS Regulation of actin cytoskeleton BCAR1 MYLK FN1 GSN SOS1 CYFIP2 FGFR3 PXN FGFR4 PIK3R3 PAK2 FGF10 BDKRB1 GIT1 ARHGEF7 GNA12 BUB1B-PAK6;PAK6 PIP4K2B PIP4K2C PAK3 PAK5 PAK4 PIP4K2A RAC3 ARHGEF6 ARHGAP35 PIP5K1A PIP5K1B CFL2 PIP5K1C CFL1 PFN1 PIK3R4 EZR PIK3R2 PIK3R1 PPP1R12A PDGFA DIAPH1 ITGA1 MAPK1 MAPK3 RHOA BRAF CRK ROCK1 ROCK2 KRAS VCL PIK3CG LIMK1 CHRM2 FGF1 CHRM3 FGF3 FGF4 APC2 VAV1 ACTG1 FGF5 FGF6 FGF7 FGF8 FGF9 PIK3R5 GNA13 FGF18 CD14 PTK2 FGFR1 FGF23 PIK3C2G PIK3C2A NRAS PIK3C2B MAP2K2;MAP2K1 F2R PDGFRB FGF20 BDKRB2 PDGFRA FGF22 FGF21 FGF17 RRAS2 MAPK6 FGF16 RRAS MAPK4 FGF14 MRAS SOS2 FGF19 PDGFB FGF13 FGF12 FGF11 EGF FGFR2 RAF1 CHRM1 ACTB-1 ARHGEF4 WAS RAC1 DOCK1 NCKAP1 CHRM4 CHRM5 MYH10 RDX EGFR RASSF7 MSN PAK1 ARPC5 SSH2 PIK3CD SSH3 SSH1 PIK3CB VIL1 DIAPH3 PIP5KL1 ENAH FGD1 WASF2 BAIAP2 MOS ABI2 SLC9A1 PIK3CA PIK3C3 ACTN1 IQGAP1 MYL1 APC WASF1-1 CDC42 ARHGEF1 F2 CSK FGF2 MYL3 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling ABCC2 MAPK14 GCLC GCLM NFE2L2 JUN GSTP1 MAPK12 MAPK13 CES1 ABCC6 MAPK11 NQO1 MAPK8 ABCG2 SRXN1 FOS EPHX1 ABCC3 NQO2 HMOX1 KEAP1 ABCC4 IL26 SIGNALING%WIKIPATHWAYS_20260211%WP5347%HOMO SAPIENS IL26 signaling NFKBIA DDIT3 RORC STAT3 ACTA2 CSF2 IL10RB MAPK9 MAPK8 SMAD2;SMAD3 STAT1 IL10 CASP3 NFATC1 IL1B IL17A CXCL8 TNF MAPK1 AKT1 MMP9 MAPK3 PIK3CA CTSK MAPK14 DCSTAMP BAX IL26 JUN TYK2 JAK2 TNFSF11 IL6 ATP6V0D2 IL20RA MPO IL33 ICAM1 CCL20 EPHA3 SOCS3 JAK1 MMP1 DEFB4A;DEFB4B RELA MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260211%WP3877%HOMO SAPIENS MYD88 distinct input output pathway TLR4 MYD88 JUN NFKB1 TLR2 TLR1 UBE2N TLR8 TLR10 TLR6 IL1A TIFA TLR5 TLR9 UBE2V1 TLR7 TRAF6 IRAK1 HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260211%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells PTPN6 PLCG1 PRKCA HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CSF2 LCP2 IFNG PRKCQ VAV1 LAT TYROBP ITPR1 TNF RAC1 NLRP7;NLRP2 ELF3 SYK FYN PTPN2 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260211%WP170%HOMO SAPIENS Nuclear receptors NR2C2 RORC RORA NR1H2 PGR AR PPARA HNF4A ESRRB NR5A1 ROR1 RARB NR2E1 RXRB RXRG NR2F1 NR0B1 NR5A2 ESR1 NR4A1 NR1H3 RARA THRB THRA NR1I3 NR1I2 NR4A2 ESRRA RXRA NR2F2 PPARG NR3C1 VDR NR1D2 RARG NR2F6 ESR2 PPARD FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260211%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 LRP1 SEL1L APOA5 LMF1 LPL CETP APOA2 APOA1 LCAT APOA4 LIPC APOC2 LDLR PLTP GPIHBP1 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260211%WP15%HOMO SAPIENS Selenium micronutrient network MTHFR CTH SOD2 SOD3 HBA2;HBA1 NFKB2 ALB TNF PRDX2 CRP CCL13;CCL2 PNPO NFKB1 IL6 PTGS1 APOA1 RFK TXN GGT1 APOB GSR LDLR SELENOK PTGS2-2 IFNG INS;INS-IGF2 IL1B CBS;CBSL INSR KMO FLAD1 KYNU GPX1 ALOX5 GPX4 PRDX3 PRDX5 ALOX15B SOD1 PRDX4 ALOX5AP SELENOI CAT SEPHS2 TXNRD3 SCARB1 SERPINA3 XDH SERPINE1 GPX6 PLAT TXNRD2 MTR-1 SELENOO MPO SELENON ICAM1 SAA2;SAA1 DIO1 SELENOS FGB DIO3 SELENOP SELENOT FGA SAA2-SAA4;SAA4 FGG F2 F7 PRDX1 PLG HBD;HBB RELA TXNRD1 ABCA1 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260211%WP5195%HOMO SAPIENS Disorders in ketolysis ACAT2 HMGCS1-1 BDH1 OXCT1-1 ACAT1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260211%WP3924%HOMO SAPIENS Hfe effect on hepcidin production HFE HAMP SMAD7 HJV TMPRSS6 BMP6 ID1 TYPE 2 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4241%HOMO SAPIENS Type 2 papillary renal cell carcinoma TGFB2 TGFB1 TGFB3 VHL VEGFA RBX1 SLC2A1 SFPQ-1 CDKN1A DIAPH1 ARNT BIRC7 PDGFB TGFA HIF1A EPAS1 TFEB ARNT2 CTSK SETD2 CADM2 EGLN1 COL21A1 EGLN3 EGLN2 FH CUL2 CREBBP ELOB ELOC-1 TFE3 PRCC DVL2 EP300 BENZENE METABOLISM%WIKIPATHWAYS_20260211%WP3891%HOMO SAPIENS Benzene metabolism EPHX1 CYP2E1 DHDH NQO1 GSTM1;GSTM2-1 MPO PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4224%HOMO SAPIENS Purine metabolism and related disorders PPAT HPRT1 ADA AOX1 MAT2A RRM2B XDH PRPS1 ADSL MOCOS AMPD1 PFAS PAICS APRT ATIC IMPDH1 DGUOK GRM5 ADSS2 GART ITPA PNP-1 TPMT 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260211%WP5546%HOMO SAPIENS 22q11 2 distal CNV DNAJB11 ERP29 PPIE SNRNP200 HYOU1 GNAZ UBA6 CABP1 AK8 CWC15 RACK1 TDRD3 ARIH1 TOP3B CCDC116 BUD31 PLRG1 YDJC RBM22 LRP4 PPM1F RNF113A PRAME RILP UGGT1 PPIL2 CDC5L XAB2 YPEL1 PPIL4 RPS27A PPIL6 PAK2 SDF2L1 CD79B CD79A PRKN UBE3A CANX HSPA5 CAMK4 EFTUD2 SNRPD2 SNRPD1 PTPA SNRPD3 RPS11 ATF6 UBA1 NEDD4 SNRPF RBX1 SNRPB BCR XBP1 MAPK1 PRPF8 SNRPE-2 RPS6 PDIA2 IGLL5;IGLL1 IQUB ROPN1L RSPH6A DHX16 DNAJB13 PPIB NME5 SOX9 SNRPA1 CHEK1 DYDC1 SF3B5 SF3B4 SF3B2 SF3B3 RSPH9 SNRPB2 SNRPG-2 RSPH3 SF3B1 SF3A3 SF3A1 HSP90B1 CALR-1 SF3A2 MDM2-2 SNRNP40 PHF5A RPS19 CDC16 RPS15 RPS14 RPS17 RPS16 RPS18 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPSA PAK1 RPS15A RPS3 RPS2 SNW1 FAU RPS29 RPS20 RPS21 RPS24 RPS23 CAMK2A CAMK1 TP53 CUL2 ELOB RNF19B ELOC-1 PPIL1-1 VPREB1 CWC22 SRRM2 CBL ZNF280D;ZNF280A AQR CRNKL1 PDIA4 RAB36 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260211%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy KCNQ2 PRKCE KCNQ3 SNAP25 PRKACA-1 NEDD4 ANK3 KCNQ1 RAB11A ITPR1 FGF13 VAMP2 RAB1A FGF12 STX1A TRAPPC3 TRAPPC2;TRAPPC2B GIGYF1 CAMK2A TRAPPC6B KCNQ4 KCNQ5 SCN2A SCN4B AKAP5 BACE1 SCN8A NEDD4L CALM1 DAG1 PRRT2 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism HSD3B1;HSD3B2 CYP11A1 HSD17B3 CYP17A1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT1A1;UGT1A6 SRD5A2 HSD17B2 SRD5A1 CYP19A1 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation CXCR4 FOSB NCKAP1L PIM1 ITGB3 ITGA2B CSF1 NOTCH1 IRF5 STAT5A CIITA CD34 TRAF3IP3 SPI1 IKZF1 HMGN5 ACVR1B TRIM29 KCNH2 LEF1 LMO2 RHOH IL6 GATA1 SEC14L2 MXI1 NFE2 RIOK3 FLI1 GP9 TPO KLF1 MUC1 RUNX1 GATA2 CSF2 FOS IL1B IL5 NFATC2 THRB IL3 LYL1 MYB TNXB VAV1 IL1A HES6 KITLG CSF3 EPO EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260211%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation PRKAR2A NEK7 RAPGEF3 IL1B NLRP3 PRKACB-1 PRKAR1B PRKAR1A H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CDK4 MED1 CDH1 CSRP2 E2F1 RB1 PMAIP1 CTNNB1 CCND1 TULP3 MACROH2A1 SOX4 JAG1 CDK8 SICKLE CELL DISEASE%WIKIPATHWAYS_20260211%WP5604%HOMO SAPIENS Sickle cell disease TLR4 IL1B HBA2;HBA1 IL18 HBD;HBB BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260211%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation CYP7A1 SLC10A1 SLC10A2 FGFR4 FXR1-1 ABCB11 FGF19 MAPK1 MAPK3 LDLR ABCG8 ABCG5 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP581%HOMO SAPIENS EPO receptor signaling MAP2K2;MAP2K1 STAT3 SHC1-1 EPOR STAT1 GRB2 SOS1 IRS1 IRS2 MAPK1 AKT1 RASA1 MAPK3 STAT5A STAT5B PIK3CG RAF1 JAK2 CISH PTPRC SRC PTPRU EPO SOCS1 PDK1 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260211%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR NRAS EGFR PTGS2-2 PIK3CD PIK3CB CYP19A1 PTGER4 PTGER2 AKT2 AKT3 MAPK1 PTGER1 AKT1 PTGER3 MAPK3 PIK3CA BRAF ESR1 KRAS PIK3CG HRAS SRC MMP1 PTGES2 PLA1A TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260211%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer STAT3 EGFR MAPK1 JAK1 MAPK3 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260211%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling IL1A STAT3 HMOX1 IL10RA IL10RB STAT2 BLVRA JAK1 IL6 STAT1 IL10 BLVRB CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260211%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer PIK3C2G PIK3C2A NRAS PIK3C2B EGFR PIK3R4 PIK3CD PIK3R2 PIK3R1 PIK3CB CYP19A1 RPTOR IGF1R INS;INS-IGF2 CDKN1A IRS1 AKT2 AKT3 MAPK1 AKT1 PIK3R3 MAPK3 PIK3CA ESR1 CDK4 CDK2 KRAS PIK3CG RAF1 CCNE1 MTOR HRAS CDK6 CCND1 PIK3R6 PIK3R5 ERBB2 CDKN1B DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260211%WP2855%HOMO SAPIENS Dopaminergic neurogenesis TGFB1 GLI2 STAT3 CDKN1C OTX2 TH RET SLC18A2 LMX1B SOX2 NKX6-1 SHH SLC6A3 ASCL1 GBX2 ALDH1A1 MSX1 NKX2-2 GLI1 DDC NR4A2 FGF8 FOXA2 NEUROD1 NEUROG2 PITX3 EN2 EN1 LMX1A WNT1 GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260211%WP2261%HOMO SAPIENS Glioblastoma signaling PRKCB FGFR1 PIK3C2G PIK3C2A PRKCD NRAS PIK3C2B PRKCA MAP2K2;MAP2K1 GAB1 MSH6 PDGFRB PDGFRA MDM2-2 PDPK1 PRKCQ GRB2 IRS1 CCND2 MET PRKCZ CDKN2A ERBB3 PLCG2 MAP2K3 PLCG1 FGFR2 MAP2K4 RAF1 NF1 CCNE1 ATM CDKN2B CDKN2C PTEN BRCA1 ARAF BRCA2 SPRY2 CDKN1B MAP2K7 EP300 MDM4 EGFR PRKCI E2F1 PIK3CD PIK3R2 PIK3R1 PIK3CB IGF1R MAP2K5 CDKN1A AKT2 ERRFI1 AKT3 MAPK1 AKT1 PIK3CA MAPK3 MAP2K6 BRAF FOXO1-1 FOXO4 CDK4 CDK2 KRAS PIK3CG RB1 HRAS CDK6 TP53 CCND1 SRC FOXO3 PRKCG CBL ERBB2 TSC2 PRKCH TSC1 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260211%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC1A1 SLC3A1 SLC7A7 SLC6A20 SLC7A9 CLTRN SLC6A19 SLC3A2 SLC36A2 JOUBERT SYNDROME%WIKIPATHWAYS_20260211%WP4656%HOMO SAPIENS Joubert syndrome ZNF423 ATF4 SHH ATM DVL1 CEP164 DVL3 CETN1 CETN2 BBS9 CEP120 BBS7 CCP110 ARR3 BBS5 TCTN3 CEP290 TCTN2 CSPP1 BBS4 OFD1-1 TCTN1 CEP97 CC2D2A ARMC9 RPGRIP1L TMEM138 ANKS6 ARL2 NPHP1 PCNT PIBF1 RAD50 RP2 RAB3IP MYO5A TMEM216 CPLANE1 TMEM231 KAT5 NIN TMEM17 KIAA0586 INVS TMEM237 CEP104 NPHP3 UNC119 RHOA B9D1 ARL3 B9D2 PDE6D ARL13B PDE6B TMEM67 PDE6A INPP5E BBS2 NEK8 RHEB BBS1 RAB8A MTOR MRE11 TTC8 MKS1 CEP41 PARP1 AHI1 FLNA MYO6 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4571%HOMO SAPIENS Urea cycle and related diseases GLS2 SLC25A13 ASS1 OTC SLC25A15 ASL CPS1 NAGS ARG1 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5292%HOMO SAPIENS Glycosphingolipid metabolism A4GALT GLA B4GALT5 GAL3ST1 B4GALT3 GBA GBA2 UGT8 B4GALT6 UGCG ST3GAL5 B4GALT4 A3GALT2 B3GALT2 B3GALT1 B4GALNT1 GALC NEU3 ARSA NEU4 B3GNT5 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260211%WP5294%HOMO SAPIENS Sildenafil treatment ZNF746 PDE4A GUCY1A2 PDE4D-1 GSK3B NOS2 PDE4B PRKN NOS1 GAPDH-1 GUCY1B1 NRF1 TFAM-1 NOS3 PRKG1 PDE4C AKT2 PPARGC1A AKT3 PDE5A AKT1 GUCY1A1 SPINAL CORD INJURY%WIKIPATHWAYS_20260211%WP2431%HOMO SAPIENS Spinal cord injury TGFB1 AQP4 CCR2 ARG1 CCL13;CCL2 BDNF EFNB2 GFAP MMP12 RHOB RHOC LTB MIF C1QB IL1R1 TNFSF13B PLA2G2A-1 PTGS2-2 IFNG RTN4R NGFR FKBP1A MYC MAPK1 MAPK3 RHOA RGMA ROCK2 TLR4 CDK4 NTN1 ZFP36 CDK2 SEMA6A NOX4 PDYN BCAN KLK8 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 COL2A1 BTG2 PPP3CA NCAN LEP TACR1 RB1 VCAN GAP43 CD47 ACAN SLIT1 SLIT3 IL1A GJA1 CCND1 SOX9 PTPRA COL4A1 SLIT2 PRKCA CHST11 LTB4R XYLT1 GRIN1 PTPRZ1 TNF CXCL2;CXCL3;CXCL1-1 MMP9 GADD45A CXCL10 CSPG4 MBP EPHA4 OMG VIM IL6 PLA2G5 PLA2G6 MAG RTN4 E2F5 RAC1 ANXA1 CDKN1B C5 EGFR E2F1 NOS1 SELP FOS CASP3 IL2 CCNG1 AQP1 IL4 CDK1 IL1B CXCL8 AIF1 NR4A1 NOS2 APEX1 GDNF CDC42 ICAM1 PLXNA2 TP53 FOXO3 EGR1 ROS1 LGALS3 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260211%WP500%HOMO SAPIENS Glycogen synthesis and degradation GSK3B PPP2R3A GBE1 GYG2 PPP2R2C GYS2 PPP2R2B GYS1 PHKA2 PPP2R1B PPP2R1A HK3 PPP2R3B PGM1 PPP2R2A;PPP2R2D UGP2 HK2 PPP2CB;PPP2CA PPP2R5E GSK3A PPP2R5B PPP2R5A PPP2R5D PPP2R5C PYGB PYGM PYGL PHKG1 PHKG2 GYG1 PHKB CALM3;CALM1 PHKA1 HKDC1 CALM1 CALM2 AGL-1 HK1 PTPA ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260211%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation UQCRFS1 SOD1 SDHA CAT VDAC1 ATP1A1 COA3 AS3MT GSTO1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism EPHX2 PTGS2-2 TBXAS1 PTGS1 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260211%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome ABI1 SYNGAP1 DLGAP1 TAB2 PAK1 GRIN1 RAP1A BAIAP2 GRIA1 ITPR1 DBNL CTNND2 CAMK2A GRIN2B DLG4 ITGB1 GRIA2 CTTN SHANK3 HRAS CDC42 ARHGEF7 ACTB-1 HCN1 GRM5 SPTAN1 MAP3K7 HOMER1 GRM1 ARHGAP44 SHARPIN LZTS3 ADGRL1 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260211%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 PHB2 TOMM70 ACAD9 NDUFAF1 TBK1 NDUFB9 NFKB2 TMPRSS2 DDX58 BCS1L CGAS IFIH1 ACE2 STING1 PHB IRF3 AGTR1 TLR3 MAVS TRAF3 TLR7 IRF7 TRAF6 NLRX1 ACE AGTR2 REN NOX1 NFKB1 CTSV;CTSL TICAM1 IKBKE ECSIT MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260211%WP4630%HOMO SAPIENS Measles virus infection STAT3 NFKB2 RACK1 MAPK10 MAPK9 MAPK8 HSPA1A;HSPA1B CCND2 CASP8 STAT2 PIK3R3 STAT5A STAT5B CCNE1 TYK2 SLAMF1 HSPA8 HSPA1L CSNK2A2 HSPA6 IKBKE OAS1 OAS3 HSPA2 IRF9 CSNK2B TBK1 IKBKG IL12B IL12A DDX58 PIK3R2 PIK3R1 IFIH1 CD3G IRF3 CD28 CD3E FADD CD3D MAVS TP73 IFNB1-4 TLR9 EIF2AK1 TRAF3 TLR7 EIF2AK4 TRAF6 EIF2AK3 EIF2AK2 TLR4 BAX CDK4 CDK2 IKBKB ADAR IL1A CCND1 CSNK2A1;CSNK2A3 IFNAR2 RELA CYCS-1 NFKBIA IFNAR1 RCHY1 NFKBIB RAB9A NECTIN4 RAB9B BID TNFAIP3 FAS IRF7 JUN NFKB1 TLR2 IL6 TRADD FASLG JAK1 CDKN1B CLEC4M;CD209-2 IRAK1 BBC3 CCND3 IRAK4 BCL2 EIF2S1 TAB2 MYD88 IL2RG CCNE2 MSN PIK3CD BAK1 PIK3CB STAT1 CASP9 FOS CASP3 CHUK APAF1 IL2 IL1B PIK3CA JAK3 BCL2L1 IL2RA BAD IL2RB CBLB CDK6 TP53 MAP3K7 EIF3H MX1-1 LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260211%WP5314%HOMO SAPIENS Lactate shuttle in glial cells SLC2A1 LDHB SLC4A4 LDHA SLC16A1 CA2 CA4 SLC1A2 SLC16A7 SLC16A3 NUDT14 HK1 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260211%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain MAP2K3 MAP2K4 MAP2K2;MAP2K1 RAF1 NFKB1 MTOR GNAQ TRIO MAP2K5 MAPK1 RAC1 AKT1 PIK3CA MAPK3 RHOA YAP1-1 MAP2K6 MAP2K7 PDK1 AMOT MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260211%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement PTK2 PLCG1 MYLK JUN TJP1 VCL ITGAV LPP ITGB3 MFAP5 MYL2 PRKCQ ITPR1 CREB1 PXN MAPK1 MAPK3 ACTN1 POLYOL PATHWAY%WIKIPATHWAYS_20260211%WP690%HOMO SAPIENS Polyol pathway SORD KHK AKR1B1 ALDOB POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP2571%HOMO SAPIENS Polycystic kidney disease pathway NRAS MAP2K2;MAP2K1 GNAS-1 WNT9B WNT9A WNT8A KDR WNT8B SSTR2 WNT7B WNT7A CTNNB1 KCNN4 CFTR TNF WNT5B WNT5A EGF PLCG2 JUN GNAQ GNAI3 WNT6 FZD10 GNAI2 DVL1 DVL2 PKD2 DVL3 WNT1 WNT2 SFRP4 WNT3 WNT4 WNT3A GSK3B PRKAG1 WNT2B PRKAG2 PRKAA2 FLT1 PRKAG3 FOS IGF1R FZD1 PRKAB2 WNT10B MYC WNT10A FZD3 WNT16 PRKAB1 FZD2 MAPK3 FZD5 PDE1A FZD7 FZD6 PRKAA1 GNAI1 BRAF FZD9 IGF1 FZD8 GNA11 RHEB KRAS RPS6KA1 WNT11 ADCY6 IKBKB MTOR HRAS PKD1 VEGFB STK11 CCND1 SRC SLC12A2 ERBB2 TSC2 FZD4 TSC1 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260211%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX ACAA1-1 DPEP1 EHHADH-1 LTB4R LTB4R2 PPARA CYSLTR2 ALOX12 LTC4S CYSLTR1 FPR2 ALOX5 LTA4H ALOX15B TRPA1 TRPV1 HPGD ALOX15 PTGR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PTGR2 ACOX2 ACOX1 GGT5 ACOX3 PPARD CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling HEY1 CNTN6 DLL1 DLK2 DLL3 MFAP1 DLL4 ADAM10 MFAP2 CHUK NOTCH2 RRAS NOTCH3 NOTCH1 NOTCH4 DLK1 LEF1 PSEN2 MAML2 MAML1 RBPJ DNER PSEN1 HES1 MAML3 JAG2 JAG1 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260211%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 CXCR4 CD82 BACH2 IFIT2 BLNK CCR7 FCRL5 CXCR5 CD1D SLAMF7 TNF SH2D1A CXCL13 TMSB10 AICDA CR2 ZEB2 EBI3 CRP PTCRA STAT5A MFGE8 ISG15 CD79A IL6 IRF4 CCL19 PTPRC IRF8 GPR183 CCL21 ETS1 HSPA8 IFITM3;IFITM2;IFITM1 IL21 CD40 CD80 TNFSF13B CD19 IL12A TBX21 CR1L;CR1 LOC110384692;C4A;C4B_2;C4B C3-1 CD40LG IFNG SELL IL10 CXCL12 BCL6 MS4A1 IL2 LOC102723996;ICOSLG IL4 CD22 BCR XBP1 TLR7 PDCD1 ICOS SYK FOXO1-1 PAX5 ITGB2 TLR4 PRDM1 CD69 ITGAX MAF IFNAR2 BTLA CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260211%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response ITGB2 VCAM1 ITGB1 ITGAL ITGA4 C3-1 IL6 SELP SELPLG ICAM1 KNG1 IL1A CXCL8 TNF C5 C6 C7 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260211%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders NT5C3A RRM1 UPB1 RRM2B UMPS DHODH RRM2-1 TYMS DPYD PUS1 NT5C TK2 CKB DPYS TYMP GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260211%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GPRC5A GRM8 GPRC5D GPRC5C GABBR2 GRM3 GABBR1 GRM5 GRM6 GRM1 GRM2 CASR GRM4 GPRC5B GRM7 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260211%WP545%HOMO SAPIENS Complement activation C9 C8B C2 MASP2 CD55 MASP1 C8G CFB CFD LOC110384692;C4A;C4B_2;C4B C3-1 C1S C1R C8A CFP C1QC C5 C6 C1QB C7 ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP1541%HOMO SAPIENS Energy metabolism GSK3B PRKAG1 PRKAG2 HDAC1 GABPA PRKAA2 NCOA1 PRKAG3 PPP3R1 SIRT1 PPARA NRF1 MEF2A MEF2C CREB1 PRKAB2 MEF2D PRKAB1 MEF2B;BORCS8-MEF2B UCP3 UCP2 PRKAA1 FOXO1-1 MAPK14 TFB1M MED1 MYBBP1A TFB2M PPRC1 ATF2 PPP3CA PPP3CB PPP3CC ESRRA CAMK2G TFAM-1 PPARGC1B PRMT1 RXRA PPARGC1A PPARG FOXO3 SIRT3 CAMK4 PPARD EP300 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260211%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes HAND2 KCNQ1 GJA1 ERG SRF HCN4 HDAC4 KCNE1;KCNE1B KCNJ2 HCN2 IGF1 PTBP2 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling IGFBP3 TGFB3 IGFBP2 ANGPT2 ANGPT1 PTGS2-2 BAK1 BID MCL1 BCL2A1 PMAIP1 VEGFA SLC2A1 BNIP3 EDN1 ARNT TGFA HIF1A PFKL PKM BAX SLC16A1 BCL2L1 EGLN1 NOS2 SERPINE1 HIF1AN BNIP3L BIRC5 TP53 LDHA PGK1 EPO HK1 IGFBP1 PDHA1 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260211%WP4565%HOMO SAPIENS Neural crest cell migration in cancer EPHB2 ARF1 STAT3 PAK1 PIK3R4 PIK3CD TIAM1 PIK3CB FOS NGFR AKT2 AKT3 AKT1 MMP9 PIK3R3 PIK3CA RHOA PAK2 CDH11 BDNF MMP2 PIK3CG JUN NTRK2 SORT1 MMP8 KIDINS220 EPHB4 EPHB6 EPHB1 EPHB3 NGEF TRIO BUB1B-PAK6;PAK6 PIK3R6 RAC1 PIK3R5 PAK3 PAK5 PAK4 F2RL2 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260211%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan AFMID TDO2 NADSYN1 NMNAT1 HAAO QPRT KMO KYNU T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260211%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling NFKBIA PTPN6 PRKCA GSK3B CSNK1A1 CD28 IL2 ITK AKT1 CTLA4 RASA1 PDCD1 NFATC2 PLCG1 LCK NFKB1 PPP3CA CD8A CD8B;CD8B2 GSK3A DYRK2 ZAP70 PTEN DYRK1A CALM1 RASGRP1 FYN PDK1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260211%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO4A1 SLC16A10 SLCO1A2 SLCO1C1 SLCO3A1 SLC7A8 SLC7A5 SLC16A2 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260211%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR2J;POLR2J2;POLR2J3 POLR3B POLR2A POLR3D TAF7 POLR3H TAF6 GTF2H2C;GTF2H2C_2;GTF2H2 POLR3K CCNH GTF2H1 GTF2H3 GTF2H4 ERCC2 POLR1E GTF2F2 ERCC3 MNAT1 TAF5 CDK7 POLR2C TBP POLR1A POLR1B POLR1D GTF2A2 POLR3E GTF2B TAF9 GTF2E1 GTF2E2 ILK POLR2B TAF12 POLR2E POLR2F POLR2G POLR2H POLR2I TAF13 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway TGFB1 AIP ALDH3A1 NFE2L2 EGFR IL12B IL12A JUND NCOA1 IFNG SERPINB2 IL2 IL17B IL1B ARNT MYOF TNF POLK CDC37 SLC7A5 PTGES3-1 JUNB AHRR BAX JUN MGST1 NQO1 HSP90AA1 UGT1A1;UGT1A6 HES1 CAP2 CYP1A1 AHR GSTA3;GSTA5;GSTA1;GSTA2 CES3 SRC CYP1A2 CYP1B1 CDKN1B IGFBP1 EP300 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation ACSL1 ACSL4 HADHA ACADVL ACSL3 SCP2 ECI1 ACSF2 CPT1A ACADL SLC25A20 ACADS EHHADH-1 PECR CPT2 ACADM HADH CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260211%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFATC3 NFATC2 NFATC4 PDCD1LG2 STAT3 JUN LCK HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E NFKB1 CD8A CD8B;CD8B2 NFAT5 IFNG CD3G BATF CD3E CD3D ZAP70 NFATC1 CD274 PDCD1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PTPN11 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP23%HOMO SAPIENS B cell receptor signaling PRKCB NFKBIA TEC PRKCD PTPN6 MAP2K2;MAP2K1 SHC1-1 GAB1 MAPK9 MAP4K1 MAPK8 MAX PDPK1 GRB2 SOS1 RASGRP3 BLNK MAPK4 CR2 ELK1 PLCG2 PLCG1 RAF1 JUN CD79B NFKB1 CD79A CARD11 BCL10 MALT1 GSK3A PTPRC ETS1 RAC1 REL PIP5K1A CD19 PIP5K1B IKBKG PIP5K1C GSK3B PIK3R2 PIK3R1 CD81 KLF11 CHUK LAT2 BCL6 DAPP1 SH3BP2 CREB1 PTPN18 BLK PIK3AP1 CD22 MYC GTF2I MAPK1 AKT1 CRKL MAP2K6 SYK CRK BRAF FOXO1-1 RAPGEF1 NFATC3 MAPK14 BTK CAMK2A NFATC2 INPP5D LYN PIK3CG RPS6KA1 ATF2 LCK IKBKB HRAS GAB2 CDC42 VAV1 NCK1 VAV2 MAP3K7 HCLS1 CBL FYN RELA PTPN11 RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260211%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS HSD3B1;HSD3B2 CYP11A1 AGT AGTR1 CREB3 CYP11B1;CYP11B2 ATF4 ITPR1 CREB1 CREB3L3 ITPR2 CTSG ITPR3 CREB3L4 CAMK1D CAMK2B CREB3L1 CAMK1G CAMK2D CMA1 ATF6B ACE AGTR2 CAMK2A REN ATF1 ATF2 CREB3L2 GNAQ CAMK1 CAMK2G CALML6 CALML3 CALM3;CALM1 CALML4 CAMK4 CALM1 CALM2 CREB5 CYP21A2 PLCB2 STAR TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260211%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma NRAS STAT3 GRB2 RPTOR SOS1 AKT2 SOS2 AKT3 AKT1 EREG BTC TGFA EGF RHEB JAK3 KRAS RAF1 TYK2 JAK2 MTOR HRAS PTEN JAK1 TSC2 PDK1 TSC1 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260211%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ NFKBIA CHUK RRAS MAP3K14 IKBKG RAF1 MAPK1 NFKB1 IKBKB MAP3K1 TRAF6 MAP2K6 SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260211%WP3944%HOMO SAPIENS Serotonin and anxiety related events PRKCB ARC PLEK HTR2A GRIN2D CRH CRHR1 PPP3CA PLCD4 NLGN1 HTR1A FOS SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260211%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction TOMM70 ACAD9 NDUFAF1 BCS1L AGT ACE2 STING1 PHB MAVS NLRP3 TNF TRAF3 NDUFAF2 TRAF6 NLRX1 ACE REN RPS6KA1 NOX1 NFKB1 IL6 IL18 TERF2 SIRT6 TERF2IP ECSIT EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260211%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle IL1R1 EIF4E HBEGF JUND CCN1 IFRD1 IL18 ANKRD1 IFNG ADAM10 NR4A3 VEGFA ATF3 IL1A ZEB1 MYOG EIF4EBP1 WDR1 MSTN DUSP14 OVARIAN INFERTILITY%WIKIPATHWAYS_20260211%WP34%HOMO SAPIENS Ovarian infertility CEBPB PGR SMAD2;SMAD3 NCOR1 CYP19A1 MLH1 SMPD1 FSHR NR5A1 RAD51 CREB1 PTGER2 SYNE2 CCND2 AKT1 ZP3;POMZP3 GJA4 LHCGR FIGLA DAZL GDF9 CDK4 MSH5 DMC1 NRIP1 INHA ZP2 ATM MTOR TBP PRLR EGR1 VDR CDKN1B TSC2 TSC1 ESR2 FMR1 BMPR1B DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260211%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets RUNX2 FLT3LG ID2-1 STAT3 SPI1 IKZF1 BATF3 CSF2 IRF4 IRF8 TCF4 CSF1 TPO TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260211%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 SUZ12 GLI3 GLI2 H3-3A ACTL6A CDKN2A SMARCA4 SMARCD1 CDK4 SMARCD2 SMARCD3 GLI4 SMARCB1 DPF1 DPF2 GLI1 DPF3 SMARCE1 RB1 SMARCC1 SMARCC2 CDK6 ACTL6B ARID1B EED PTCH1 RBBP4 ARID1A SMO EZH2 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260211%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PYCR1 ALDH4A1 OAT PEPD PRODH;LOC102724788 NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260211%WP288%HOMO SAPIENS Nod like receptor NLR signaling CD40 CHUK EPHB2 IKBKG MAP3K7 IKBKB MAPK8 RELA ERBIN BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260211%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling STAT3 PTPRF FRS2 RACK1 MAPK10 MAPK9 MAPK8 GRB2 GRIP1 MEF2A NSF MEF2C GRIA1 SYN1 MAP3K2 MAP3K1 ELK1 STAT5A RPS6KA3 STAT5B BDNF CRTC1 DLG1 GRIA2 RHOG GRIA3 YBX1 CAMK4 CYFIP1 NTF3 IKBKG CFL1 PIK3R2 TIAM1 PIK3R1 PRKAA2 MAP2K5 NGFR EEF2 MAPK1 AKT1 RAB3A GABRB3 MAPK3 RPS6 TRAF6 PRKAA1 NCF2 GRIN2B MAPK7 RPS6KB1 SH2B2 PPP2CB;PPP2CA RPS6KA1 NTRK1 LINGO1 NTRK2 NTRK3 SORT1 IKBKB JAK2 KIDINS220 SQSTM1 HRAS VAV2 DPYSL2 SRC SIRPA;SIRPB1;SIRPG MAPT CSNK2A1;CSNK2A3 EIF4EBP1 TSC2 FYN RELA PTPN11 NFKBIA PRKCD MAP2K2;MAP2K1 SHC1-1 RASGRF1 PDPK1 GRIN1 RAP1A CTNNB1 CDK5R1 IRS1 IRS2 SHC4 SHC2 SHC3 EIF4E CNR1 ADAM17 PLCG1 CDH2 RAF1 JUN NFKB1 NGF RAC1 EIF2S1 CDK5 GSK3B STAT1 NCF1 CASP3 CHUK CREB1 KSR1 ACACB MAPK14 CAMK2A NFATC4 PTK2B BAD MTOR APC CDC42 IGF2BP1 CAMK1 NCK2 CDKL5 NCK1 RPS6KA5 FRS3 EIF2S2 VAV3 DOK5 KCNN2 DOCK3 KCNA3 FOXO3 NCAM1 SH2B1 RANBP9 MARCKS HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260211%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis MAPK14 BCL2 BAX CASP7 MAPK12 MAPK13 BCL2L1 BAD MAPK11 BID MCL1 CASP9 CASP3 FADD APAF1 FASLG TNF CASP8 AKT1 BBC3 BCL2L11 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260211%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid GPX4 PTGS2-2 CYP1A2 CYP2C9;CYP2C19 EPHX3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ALOX12B ALOXE3 ALOX15 PTGS1 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260211%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia ZAP70 TP53 BCL2 MCL1 TAR SYNDROME%WIKIPATHWAYS_20260211%WP5362%HOMO SAPIENS TAR syndrome SLK PEX19 SUMO2 CXCR4 PDZK1 HJV RBCK1 SLC22A4 GPR89A;GPR89B STAT3 PEX11B CLCN3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E BCL2L13 FURIN SLC9A3R1 TNFRSF14 MAGOH;MAGOHB FARP2 UBE2I BRF1 POLR3GL CD160 SIRT1 PYM1 PDZK1IP1 POLR3C POLR3F POLR3G CFTR ITGA10 MITD1 MET DNM1 NFKB1 HAMP HDAC2 TXN EGFR ZFHX3 IFNG CD247 CD3D DDIT4 FLT3 MTA1 ITGB1 CCAR2 LCK PIAS3 LAMTOR1 ANKRD35 EIF4A3 SLC22A12 AKAP10 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260211%WP455%HOMO SAPIENS GPCRs class A rhodopsin like NPFFR1 ADORA2B OPRK1 RHO HTR1A CCR2 GPR37 ADRA2C ADRA2B ADRA2A HTR5A CNR2 FFAR3;GPR42 FFAR2 FPR2 LPAR4 GPR32 HTR4 HTR6 LPAR5 LPAR6 OXTR MC1R F2RL2 GPR161 GPR15 P2RY6 P2RY4 BDKRB2 P2RY2 LTB4R HRH3 CCR7 PTGER4 PTGER2 CXCR5 C3AR1 AGTR2 CHRM1 C5AR2 FPR1 GPR75 ACKR3-2 GPR68 PTGER1 PTGER3 CYSLTR1 LHCGR HTR7 CCR6 MC3R MAS1 AGTR1 NPFFR2 RRH GPR174 GPR173 GPR171 EDNRB CMKLR1 GPR37L1 NPY1R TRHR OR7A10;OR7A17-11 OR2AG1;OR2AG2 OR1I1 MC2R GALR3 GALR2 NPBWR1 GALR1 CCR9 NPBWR2 OR6B1 CCR10 BDKRB1 NTSR2 NPY2R CCR1 XCR1 GPR12 HCAR2;HCAR3 OR6A2 GPR19 ADORA1 GPR27 GPR25 GPR21 GPR22 GPR20 NPY4R2;NPY4R OR10H1;OR10H5;OR10H2 MTNR1A BRS3 AVPR1B MTNR1B CCKAR CCR8 CCR4 GPR39 GPR34 FFAR1 GPR35 OR1A1-1 AVPR1A OR2S2-1 OR3A2 OPRD1 DRD1 GPR45 DRD2 PTAFR DRD3 CHML DRD4 P2RY12 P2RY10 OPN4 P2RY14 OPN3 GPR52 GPR1 OR8D2-1 GPR50 GPR4 GPR3 GPR6 MC5R F2RL3 OR1C1 GPR65 GPR63 OR2D2 OR2T1 ADORA2A APLNR OR5V1-2 OR2C1 SUCNR1 OR5I1 GPR87 GPR85 MCHR1 OPRL1 CCRL2 OR1Q1 HRH1 HCAR1 HRH2 OR2B3 DRD5 HTR1E HTR1D HTR1B HCRTR2 OR2J1;OR2J2;OR2J3-2 NMUR2 HCRTR1 NMUR1 OR14J1 CHRM2 MLNR CHRM3 HTR2B OR7C1;OR7C2-9 PRLHR ADRA1D NPY5R HTR2A OR2H2 OPRM1 SSTR1 GRPR SSTR3 AVPR2 SSTR4 SSTR5 GPER1 OR10A4 CX3CR1 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW EDNRA OR8B8 OR2W1 OR12D3 OR1D2 ADORA3 OR10J1-2 OR2B6;OR2B2-1 OPN1SW CXCR4 ACKR4 CCR5 ACKR2 OR11A1 OR1F1 F2R OR2H1-1 SSTR2 CCKBR FSHR OR1E1;OR1E2 CYSLTR2 OR10A5 OR3A1 OR2A7;LOC107987545;OR2A4 ADRB2 CXCR1 CNR1 CXCR3 CXCR2 PTGFR NTSR1 P2RY13 GPR17 PTGDR2 P2RY11 GPR83 HTR1F OR2F1-2 TBXA2R PTGDR PTGIR GPR18 CHRM4 CHRM5 ADRB1 NMBR ADRA1B ADRA1A CCR3 MC4R F2RL1 P2RY1 GHSR ADRB3 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260211%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 CYP2E1 MAFF MAP2K2;MAP2K1 NFE2L2 MAFG MAPK8 MAFK SP1 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260211%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis CD40 IRF5 CCR6 SLC22A4 CIITA FCRL3 PTPN22 PADI4 CD244 IL2RA PHF19 STAT4 ITGAV IL6ST TRAF1 BLK CTLA4 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260211%WP1995%HOMO SAPIENS Effects of nitric oxide NOS3 AOX1 HBA2;HBA1 NOS2 MB XDH NOS1 HBD;HBB HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma FGFR1 NRAS NFKB2 GAB1 SESN2 CSMD3 PDPK1 FGFR3 NOTCH2 CTNNB1 NOTCH1 CASP8 AJUBA CDKN2A EIF4E SMAD4 MAPKAP1 RPS6KB2 FGFR2 NFKB1 PTEN KEAP1 FAT1 TGFBR2 SESN1 REL NFE2L2 EGFR E2F1 PIK3R2 PIK3R1 PIK3CB PRKAA2 RPTOR VEGFA IRF6 TP63 FADD IGF1R MLST8 FKBP1A CDKN1A AKT2 AKT3 AKT1 TRAF3 PIK3CA DDIT4 RPS6 PRKAA1 BIRC2 CUL3 CDK4 RHEB KRAS PIK3CG MAML1 MTOR RB1 HRAS CDK6 NUMB TP53 STK11 CCND1 PIK3R5 TERT ERBB2 EIF4EBP1 RICTOR TSC2 TSC1 RELA SERINE METABOLISM%WIKIPATHWAYS_20260211%WP4688%HOMO SAPIENS Serine metabolism PHGDH PSPH SRR SHMT1 TYMS DHFR2;DHFR PSAT1 SHMT2 CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260211%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway NFKBIA NFKBIB TRIM25 ZBP1 RNF125 AIM2 POLR2L CYLD POLR3GL TREX1 POLR3A POLR3C POLR3F POLR3G CASP8 CXCL10 IRF7 CASP1 ISG15 CCL5 NFKB1 IL6 IL33 TRADD POLR3E CASP10 CCL4L2;CCL4L1;CCL4 RIPK3 POLR2E POLR2F RIPK1 IKBKE POLR2H POLR3B POLR3D POLR3H TBK1 IKBKG POLR3K DDX58 CGAS STING1 IRF3 CHUK FADD MAVS IL1B IFNB1-4 NLRX1 ATG12-1 PYCARD IKBKB ADAR IL18 POLR1C POLR1D ATG5 RELA BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260211%WP5606%HOMO SAPIENS Beta globin gene expression regulation NR2C2 MYB LMO2 HDAC1 GATA1 TAL1 KDM1A HBG2;HBG1 LDB1 BCL11A DNMT1 NR2C1 HDAC2 KLF1 ZFPM1 PPARGC1A ZBTB7A CHD3 MTA2 GATAD2B HBD;HBB PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260211%WP4022%HOMO SAPIENS Pyrimidine metabolism UPP1 POLR2A TK1 ENTPD1 RRM1 POLE4 UPB1 NME1 UCK1 POLR1E UMPS RRM2-1 POLR2L POLR3GL POLR3A POLR3C TYMS POLR3F POLR3G ENTPD3 NME2 NME3 CTPS2 POLA2 CTPS1 NT5C TK2 DCK DCTD NME6 NME7 CMPK1 CMPK2 CAD POLR1F UPRT POLR1H DCTPP1 PRIM2 DTYMK NME4-1 POLR2D NT5M DUT PNPT1 UCKL1 POLA1 POLR3E PRIM1 POLR2B POLR2E POLR2G POLR2H POLR2I POLR2J;POLR2J2;POLR2J3 POLR3B POLR3D POLR3H POLR3K RRM2B ENPP3 POLD3 POLD4 POLD1 POLE POLE2 POLR2C POLE3 DHODH POLR1A POLR1B POLR1C POLR1D ENPP1 DPYD CDA DPYS POLD2 TYMP GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260211%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein PCSK1 SLC2A2 SLC5A1-1 GNAQ GCG ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260211%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis KCNQ2 TRPA1 KCNQ3 FAAH TRPV1 PTGS2-2 CACNA1H HTR1A PTGS1 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260211%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells EGF SOD1 SPP1 TLR4 STAT3 EGFR IL6 KDR BIRC5 ETS2 CD63 CD81 SORBS2 GATA4 PTEN HSPB1 MMP9 IGF1 PDLIM5 ADIPOGENESIS%WIKIPATHWAYS_20260211%WP236%HOMO SAPIENS Adipogenesis ID3 TGFB1 STAT3 NCOA2 SMAD2;SMAD3 AGT LPIN1 LPIN2 NCOR1 LPIN3 IL6ST PPARA MEF2A GATA4 MEF2C HNF1A FOXC2 MEF2D STAT2 MIXL1 MEF2B;BORCS8-MEF2B HIF1A BMP4 KLF6 STAT5A NR1H3 STAT5B ZMPSTE24 LMNA BMP2 PCK1 MIF SFRP4 SREBF1 DDIT3 CEBPA CEBPB EGR2 CEBPD GATA3 GATA2 KLF15 KLF5 INS;INS-IGF2 FZD1 WNT10B CDKN1A RXRG EPAS1 FOXO1-1 IGF1 SCD DLK1 RARA NRIP1 E2F4-1 ASIP CELF1 LEP MBNL1 RB1 PRLR AHR OSM SOCS3 SOCS1 PNPLA3 CYP26A1 NCOA1 CYP26B1 FAS CTNNB1 RETN IRS1 IRS4 IRS2 TNF GADD45A WWTR1 BMP1 ADIPOQ WNT5B CFD LPL LIF IL6 SP1 RBL2 RBL1 CNTFR EBF1 GTF3A BSCL2 NDN PTGIS RXRA BMP3 PLIN2 DVL1 AGPAT2 NR3C1 FRZB SPOCK1 GDF10 KLF7 PPARD LIFR WNT1 RORA E2F1 SLC2A4 STAT6 STAT1 GADD45B LIPE CISD1 CREB1 NR2F1 SERPINE1 NCOR2 NAMPT PPARGC1A PPARG TRIB3 PCK2 PLIN1 UCP1 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260211%WP247%HOMO SAPIENS Small ligand GPCRs CNR1 PTAFR S1PR1 S1PR3 PTGFR GPR50 TBXA2R PTGER4 S1PR2 PTGDR PTGIR PTGER2 LPAR1 MTNR1A CNR2 MTNR1B PTGER1 PTGER3 S1PR4 MONOAMINE GPCRS%WIKIPATHWAYS_20260211%WP58%HOMO SAPIENS Monoamine GPCRs CHRM4 DRD1 CHRM5 DRD2 ADRB1 DRD3 DRD4 ADRA1B ADRA1A ADRB2 HTR1A HTR4 HRH1 HTR6 HRH2 DRD5 HTR7 HTR1E ADRA2C HTR1D ADRA2B HTR1B ADRA2A HTR1F CHRM2 CHRM3 HTR2B CHRM1 ADRA1D HTR5A HTR2A ADRB3 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260211%WP554%HOMO SAPIENS ACE inhibitor pathway REN TGFB1 BDKRB1 AGT BDKRB2 ACE2 MAS1 AGTR1 CYP11B1;CYP11B2 ATP6AP2 KNG1 NOS3 CTSG CMA1 ACE NR3C2 AGTR2 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260211%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth HIPK1 HIPK2 CDKN1B HMBOX1 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260211%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGB2 MADCAM1 VCAM1 ITGB1 ITGA4 SELE ITGA2 SELPLG ITGB7 ICAM1 SLEEP REGULATION%WIKIPATHWAYS_20260211%WP3591%HOMO SAPIENS Sleep regulation NPAS2 MRGPRX3;MRGPRX4;MRGPRX1;MRGPRX2-3 DRD1 ADA DRD2 DRD3 AHCY CACNA1I BTBD9 TH SLC29A1 GRIN2A FOS CRH NPS ADORA2A CST3 NLGN1 DLAT GHRH GHRL HCRTR2 OXTR UTS2R NPY2R HCRTR1 IL6 IL18 ADORA1 PTGDS CHRNB2 HTR2A PTGDR OXT-1 MTNR1B STAR PRION DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP3995%HOMO SAPIENS Prion disease pathway PTK2 FGFR1 BCL2 PDIA3 RFX5 STAT3 HSP90B1 BATF CASP3 BCL11A MEF2C CREB1 SMC3 MAPK1 MAPK3 ELK1 CTCF PAX5 SPI1 CHD2 NFKB1 POU2F2 IRF4 TBP EBF1 RXRA NCAM1 HSPA5 PRNP FYN EP300 RAD21 INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260211%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation MYO15A DRG2 CCDC65 CLTC STAT3 CLTA GRIP1 SHMT1 ARNTL ARG2 NR1H3 PER1 PRKN FOXA1 IRF8 APP FOXA2 PCK1 TFE3 TRAF3IP1 FLCN IFT52 ATG13 SREBF1 RAI1 IFT57 ULK1 CFL2 PRKCI PPP1R14A IFT80 PPP1R12A PARD3 RPTOR MLST8 MAP3K14 PEMT MYC CRY2 CRY1 RHOA YAP1-1 TFEB PRKAA1 FHOD1 GPR85 ROCK1 PARD6B TLR4 BAX PRDM1 RAB8A IFT172 HSPB11 LIMK1 IFT74 MED9 CLUAP1 HES6 CLEC16A RELA IFT81 NR1H2 IFT27 APBB1 BLM TNF BCL2L11 WWTR1 JUN CARM1 NFKB1 NT5M PTEN G6PC1 ATG101 TOLLIP FERD3L MYD88 ALKBH5 MAEA MPRIP DENR PRKAG2 MIGA2 MIGA1 RAB10 ARMC8 DRC3-1 RNF41 TOM1L2 RB1CC1 RRAGA IFT88 BCL6 TTC30A;TTC30B LLGL1 IQCA1 CREB1 DRC7 CDK1 IL1B ATPAF2-2 COPS7A PLD6 PRKAB1 RAB39B COPS4 IFT20 COPS3 USP8 COPS6 IFT22 COPS5 BIRC2 COPS2 HBP1 DRC1 COPS8 CLTB TTC26 TNFRSF13B GDI2 WDR41 EFCAB2 RMI2 RMI1 TOP3A MTOR ITPK1 IQCD IQCG ETV5 CLOCK TCTE1 TP53 SMCR8 IFT46 GAS8 C9orf72 WDR26 LDHA GPS1 MIEF2 RMND5A RANBP9 RASD1 FNIP1 FLII FNIP2 FBXL13 MYO16 MKLN1 GID4 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260211%WP5028%HOMO SAPIENS Glycine metabolism including IMDs LIPT2 PNPO LIPT1 GLDC GLRX5 GCSH-3 AMT IBA57 HSCB DLD LIAS NFU1 BOLA3 ISCU SHMT1 PI3K AKT SIGNALING%WIKIPATHWAYS_20260211%WP4172%HOMO SAPIENS PI3K Akt signaling COL9A2 SGK1-1 FN1 COL1A1 GRB2 G6PC3 SOS1 COL6A6 FGFR3 COL6A5 CCND2 FGFR4 PPP2R3B FGF10 BDNF CCNE1 PCK1 GHR NTF3 CD19 G6PC2 IL6R FLT1 PDGFA TCL1B IGF1R TCL1A NGFR INS;INS-IGF2 PPP2R1B CREB3L3 AKT2 CDKN1A PPP2R1A MYC IFNB1-4 CREB3L4 AKT3 CREB3L1 MAPK1 AKT1 CDC37 DDIT4 MAPK3 PPP2R2A;PPP2R2D INSR FLT3 EPHA2 LPAR2 LPAR3 IGF1 LPAR4 GNG10 PGF LPAR5 TLR4 LPAR6 CDK4 CDK2 ITGB1 PPP2CB;PPP2CA PRL KRAS PIK3CG ATF2 NTRK2 OSMR JAK2 COL2A1 KIT PHLPP2 TNXB FGF1 FGF3 PRLR RELN FGF4 VEGFB FGF5 OSM FGF6 VEGFC FGF7 VEGFD FGF8 FGF9 KITLG CSF3 PIK3R6 CSF3R PIK3R5 EPO TNN TNR EIF4EBP1 IFNAR2 COL4A2 FGF18 COL4A1 PTK2 EIF4E1B FGFR1 COL4A4 COL4A6 IFNAR1 PRKCA CSF1R EFNA5 EFNA4 HSP90B1 CHAD IL7 FGF20 FGF22 ITGB3 FGF21 ITGA2B FGF17 EFNA1 ATF4 EFNA3 FGF14 LAMC1 EFNA2 LPAR1 IBSP ITGA10 FGF19 ITGA11 IL7R FGF13 ITGA2 FGF12 FGF11 HSP90AB1 ITGB5 LAMC3 TNC ITGB4 FLT4 LAMC2 PPP2R5E TLR2 NFKB1 ITGB8 GNG13 ITGAV ITGB6 IL6 HSP90AA1 LAMA5 VWF GNB2 ITGA3 PPP2R5B RBL2 CHRM1 PPP2R5A PPP2R5D PPP2R5C NGF GNB1 GNB4 G6PC1 GNB3 COL6A2 GNB5 ITGA8 FASLG ITGA7 THBS1 ITGA6 ITGA5 VTN ITGA9 CDKN1B CREB5 LAMA2 LAMA1 LAMA4 CCND3 LAMA3 THBS2 THBS4 NTF4 SPP1 BCL2 THBS3 PPP2R3C FLT3LG ANGPT4 ANGPT2 GNGT1 LAMB3 ANGPT1 CCNE2 LAMB2 PPP2R3A LAMB1 EPOR PPP2R2C PPP2R2B TEK CREB3 CREB1 PIK3AP1 ATF6B GNG2 GNG5 PKN3 GNG4 PKN1 GNG8 NOS3 PDGFD COL1A2 PHLPP1 SGK3;C8orf44-SGK3 PIK3R3 IKBKG IGF2 PIK3R2 PIK3R1 PRKAA2 RPTOR MLST8 COL4A3 EIF4B ITGA1 COL6A1 COL4A5 COL6A3 RPS6 PRKAA1 LAMB4 RPS6KB1 RHEB MYB NTRK1 CREB3L2 IKBKB HRAS CHRM2 STK11 CCND1 TSC2 TSC1 RELA FGF23 NRAS MAP2K2;MAP2K1 F2R KDR PDGFRB PDGFRA MDM2-2 PDPK1 HGF CSF1 IRS1 EIF4E2 SOS2 MET PDGFB TGFA BCL2L11 PDGFC EIF4E EGF RPS6KB2 FGFR2 PKN2 RAF1 PTEN BRCA1 RAC1 JAK1 IL2RG EGFR THEM4 GSK3B PIK3CD MCL1 PIK3CB CASP9 GYS2 VEGFA IL4R GYS1 CHUK IL2 IL4 PIK3CA SYK IL3RA IL3 JAK3 BCL2L1 IL2RA BAD IL2RB ITGA4 MTOR CDK6 ITGB7 TP53 FOXO3 PCK2 FGF2 COMP COL9A1 COL9A3 HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260211%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis NRXN2 BCL2 DRD1 NRXN1;NRXN3;NRXN2 PRKCA SYT2 SYT12 CREB1 CCND2 CAMK2B MAPK1 MAPK14 CAMK2A CAMKK1 CAMKK2 BDNF HNRNPL PRL RPS6KA1 RPS6KA5 NGF PPARGC1A NCAM1 CAMK4 CALM1 NRXN3 CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260211%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling DAGLA CNR1 RYR3 CD38 TRPC1 GNAQ CCK CCKBR ITPR1 RYR1 PLCB1 RYR2 GNAI1 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260211%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway ULK1 PIK3R4 RPTOR RB1CC1 SPTLC1 DEPTOR MLST8 WDR45 DCAF17 WIPI1 WIPI2 C19orf12 ATG3 GTPBP2 MAP1LC3A COASY FA2H PIK3C3 PRKAA1 BECN1 ATG12-1 RHEB ATG2A ATG16L1 AKT1S1 SCP2 ATG4A MTOR PLA2G6 ACACA STK11 ATG101 ATG7 ATP13A2 ATG5 FTL-1 ATG14 TSC2 ATG10 TSC1 ATG13 MECP2 CP CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260211%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II REN CTSG CTSD CMA1 ACE PEPTIDE GPCRS%WIKIPATHWAYS_20260211%WP24%HOMO SAPIENS Peptide GPCRs CCR6 GNRHR CXCR4 CCR5 TSHR BDKRB2 SSTR2 MC3R OPRK1 AGTR1 CCKBR FSHR CCR7 CXCR5 C3AR1 ATP8A1 TACR2 EDNRB TACR3 NPY1R CXCR6 CCR2 TRHR TAC4 AGTR2 CXCR1 MC2R CXCR3 GALR3 CXCR2 GALR2 CCR9 GALR1 NTSR1 BDKRB1 CCR10 NPY2R NTSR2 CCR1 C5AR1 ACKR1 FPR1 NPY4R2;NPY4R BRS3 AVPR1B CCKAR CCR8 CCR4 AVPR1A OPRD1 NMBR MC5R CCR3 LHCGR OPRL1 FPR2 HCRTR2 OXTR MC4R HCRTR1 TACR1 MC1R NPY5R OPRM1 GHSR SSTR1 GRPR SSTR3 AVPR2 SSTR4 SSTR5 CX3CR1 EDNRA NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome MDC1 CBX3-1 NIPBL ATM RNF168-1 RNF8 ATR METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260211%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer PPAT PYCR1 PGD PDHB GLUD1;GLUD2 SLC16A3 GAPDH-1 SLC2A1 ACO2 GLS RPIA TALDO1 HK3 SDHB PYCR2 PFKL IDH3A GPI TIGAR PKM ACLY TKT GOT2-1 ALDOB PAICS FH SLC1A5 DLST PSPH FASN GART LDHA PGK1 G6PD IDH2 SUCLG2 ENO1 PGAM1 PSAT1 SHMT2 PDHA1 MDH2 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism EPHX2 ALOX15 ALOX5 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260211%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases MAPK14 SMAD4 NFKBIA MED14 DUSP1 MAP2K3 IKBKG NFKB1 IKBKB PPP3CA IL6 SMAD2;SMAD3 PPP3R1 CHUK NFATC1 RXRA TNF MAP3K1 VDR NR3C1 MAP2K6 RELA NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260211%WP4564%HOMO SAPIENS Neural crest cell migration during development EPHB2 ARF1 STAT3 PAK1 PIK3R4 PIK3CD TIAM1 PIK3CB FOS NGFR AKT2 AKT3 AKT1 MMP9 PIK3R3 PIK3CA RHOA PAK2 CDH11 BDNF MMP2 PIK3CG JUN MMP8 EPHB4 EPHB6 EPHB1 EPHB3 NGEF TRIO BUB1B-PAK6;PAK6 PIK3R6 RAC1 PIK3R5 PAK3 PAK5 PAK4 F2RL2 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP304%HOMO SAPIENS Kit receptor signaling PRKCB TEC PTPN6 PRKCA MAP2K2;MAP2K1 STAT3 SHC1-1 MAPK8 GRB2 SOS1 MITF STAT5A RPS6KA3 STAT5B MATK SOCS6 PLCG1 RAF1 GRB7 EP300 PIK3R2 PIK3R1 STAT1 MAPK1 AKT1 CRKL MAPK3 RPS6 CRK MAPK14 BTK INPP5D LYN RPS6KB1 SH2B2 DOK1 RPS6KA1 JAK2 BAD KIT HRAS GAB2 VAV1 GRB10 SRC FOXO3 KITLG MAPT SOCS1 CBL FYN PTPN11 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260211%WP694%HOMO SAPIENS Arylamine metabolism CYP1A2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260211%WP3527%HOMO SAPIENS Pre implantation embryo ZFP36L2 FOSB HNRNPAB MXD1 SOX2 ZFP42 KLF4 SOX11 TFAP2E;TFAP2B SMARCA4 NANOGNB SOX8 CELF3 AQP9 DNMT3L CDH1 KHSRP MYBL1 ZAR1 DPPA3 DLX2 PADI6 BARX2 IRF4 LEUTX NLRP5 DPRX-1 TBX3 TCF7L1 TPRX1;RAX2 CDX2 ZSCAN4 E2F5 NR3C2 IRX5 DDIT3 GATA3 GATA2 ELAVL1 SIX3 MOS MTA3 FOXQ1 FOXD1 ZFP36 BATF3 ESRRA PBX1 NKX2-1 AQP3 NANOG;NANOGP8 POU5F1;POU5F1B ATP1A1 EGR1 TEAD4 MACROH2A2 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260211%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 LRP1 SCARB1 LPL CETP APOA2 APOA1 VLDLR APOE LCAT APOA4 LIPC LDLR PLTP DNA REPLICATION%WIKIPATHWAYS_20260211%WP466%HOMO SAPIENS DNA replication RFC2 RFC1 MCM2 RFC3 ORC5 RFC4 ORC4 ORC6 RPA2 ORC1 ORC3 ORC2 CDC7 CDC6 MCM7 RPA3 RPA1 DBF4 POLA2 MCM3 MCM5 MCM6 POLD3 UBB;UBC POLD4 CDC45 POLD1 POLE CDK2 MCM4 PRIM2 PCNA POLE2 GMNN POLA1 UBA52 MCM10 CDT1 PRIM1 POLD2 RFC5 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260211%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways SIN3A CASP7 MAPK10 MAPK9 MAPK8 BNIP3 HMGCS2 CASP8 PIK3R3 ELK1 BDNF MAP2K4 PRR5L MAP3K10 HDAC2 ABCG4 NEUROD1 HAP1 RAB3GAP1 CYP51A1 DHCR7 PIK3R4 PIK3R2 PIK3R1 PRKAA2 RPTOR DEPTOR HMGCS1-1 MLST8 APOE AKT2 AKT3 MAPK1 AKT1 RAB3A GABRB3 MAPK3 GABRB2 GABRB1 PRKAA1 GABRE GABRD GABRQ GABRA2 GABRA1 GABRP BAX SLC12A5 RPS6KB1 RHEB GABRA6 GABRA5 PIK3CG AKT1S1 GABRA4 NTRK2 GABRA3 GABRG1 IKBKB HRAS PIK3R6 PIK3R5 GRM1 EIF4EBP1 TSC2 TSC1 CYP46A1 PIK3C2G PIK3C2A NR1H2 PIK3C2B MAP2K2;MAP2K1 BID ITPR1 KIF5A BCL2L11 CKB EIF4E EGF MBP RAF1 NFKB1 IL6 SREBF2 SP1 ABCG1 HTT PTEN REST MAP2K7 BCL2 GABRG3;GABRG2 EGFR PRKAG1 PRKAG2 PIK3CD HDAC1 PIK3CB PRKAG3 CASP3 CREB1 PRKAB2 IL1B PRKAB1 PIK3CA BCL2L1 BAD MTOR HMGCR RPS6KA5 SLC12A2 PPARGC1A AHI1 OPA1 RICTOR ABCA1 SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260211%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1C3 SULT1C2 SULT2A1-4 SULT4A1 SULT1B1-1 G6PD SULT2B1 PAPSS2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 GSR PAPSS1 SULT6B1 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260211%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition RPS6KB1 IRS1 AKT2 SLC2A4 INSR MTOR RPS6 TBC1D4 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260211%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity TGFB2 TGFB1 TGFB3 CASP7 CAP1 HTRA2 XIAP ATP8B1 CASP8 CLU CX3CL1 C8G C1R PATJ C4BPB ATP11C SCRIB TYRO3 C1QB LLGL2 MARK3 ATP8B3 DLGAP5 C2 PLSCR3 PLSCR4 CRB2 COLEC12 CRB1 LOC110384692;C4A;C4B_2;C4B PRKCI COLEC10 PARD6G ATP10A C3-1 PARD3 SUSD4 IFNG CSMD1 DEDD C1QC ITGAM ITGB2 PARD6B PARD6A BAX ITGAX MARK2 MARK1 CX3CR1 CYCS-1 MPP5 BID ITGB3 PROS1 FAS C4BPA C8A GAS6 C3AR1 ATP11A PRKCZ CR2 FCN2;FCN1 COLEC11 AXL MBP C8B MBL2-1 SERPING1 MFGE8 MASP2 MASP1 CFB CFD ITGAV C1S C5AR2 C5AR1 CFI CFP CASP10 FASLG DIABLO-1 VTN C5 C6 C7 C9 CD59 CD55 CR1L;CR1 BAK1 CASP9 CFH-3 CASP3 APAF1 ATP8B2 PLSCR1 MERTK CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260211%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling PRKCB PTK2 NFKBIA FOSB PRKCD TGFB1 GNAZ PRKCA MAP2K2;MAP2K1 GNAS-1 NCOA2 MAPK9 JUND MAPK8 PRKCQ POMC CTNNB1 CRHR1 ECE1 ELK1 MAP3K5 JUNB GRK6 FOSL2 PLCG2 FOSL1 ERN1 PLCG1 RAF1 NFKB1 HSP90AA1 SP1 GNB2 GNAQ ACACA TCF4 GNB1 RAPGEF3 GNB3 GNB5 GNAI2 CYP21A2 ARRB1 HSD3B1;HSD3B2 BCL2 ARRB2 CYP11A1 GSK3B PRKCI CACNA1H PRKAA2 CASP9 TFAP2A CRHBP FOS CASP3 KRT1 RAP1B IVL CYP11B1;CYP11B2 CRHR2 TBX19 CREB1 IL2 GNAO1 CRH TRIM28 CXCL8 MAPK1 AKT1 MAPK3 RHOA GNAI1 BRAF NR4A1 MAPK14 CAMK2A TLR4 GRK3 GNA11 KRT16;KRT14 IL18 JUP NR4A2 PARP1 NOS3 GJA1 SULT2A1-4 STAR RELA SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260211%WP3947%HOMO SAPIENS Serotonin and anxiety PRKCB GABRA1 PLEK ARC TRPV1 PPP3CA PLCD4 ADRA1A FOS POMC HTR2A CRH CAMK2B GRM1 EEF2K HTR1A FMR1 IL1 SIGNALING%WIKIPATHWAYS_20260211%WP195%HOMO SAPIENS IL1 signaling NFKBIA NFKBIB MAP2K2;MAP2K1 MAPK9 MAPK8 PRKCZ MAP3K2 MAP3K1 HSPB2 MAP2K3 PLCG1 MAP2K4 JUN NFKB1 TAB1 UBE2N IL1RAP IRAK1 MAP2K7 ECSIT IRAK2 IL1R1 IRAK4 TOLLIP REL TAB3 TAB2 MYD88 IKBKG PIK3R2 PIK3R1 MAPKAPK2 CHUK MAP3K14 IRAK3 IL1B PELI1 PELI2 UBE2V1 MAPK1 AKT1 MAPK3 TRAF6 MAP2K6 MAPK14 MAP3K3 ATF2 IKBKB SQSTM1 IL1A MAP3K7 RELA PTPN11 PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases NT5C3A GLS2 CAD RRM1 UPB1 RRM2B CPS1 UMPS DHODH RRM2-1 ABAT ALDH6A1 TYMS OTC DPYD AGXT2 NT5C TK2 DPYS TYMP OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ACSL1 ACSL4 ACSL3 ACOT2;ACOT1 ELOVL3 ELOVL5 FADS2 FASN FADS1 ELOVL1 SCD5 ELOVL6 ELOVL2 SCD TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260211%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc SDHA DLAT ACLY CS ACO1 DLD PC FH OGDH DLST PCK1 SUCLG2 PDHA1 MDH1 IDH1 IDH3A 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome PTK2 POLR1E POLR2L GRB2 ARF6 CSF1 GAS6 IL1RN CXCL13 IL36A IL36B BCL2L11 IL36RN IL36G POLR1F PLCG2 IL1F10 POLR1H IL6 IL37 RAC1 POLR2E IL1RAP POLR2F POLR2H IL1R1 ANAPC1 GATA3 CSF2 STAT1 IL23A IL2 IL1B MAPK1 ZC3H8 ZC3H6 CHCHD5 ACOXL PSD4 ARL14 CKAP2L POLR1G FBLN7 TMEM87B SLC20A1 TULP1 TTL IL1RL2 POLR1A POLR1B POLR1C POLR1D IL1A SOCS3 SOCS1 MERTK LGALS3 HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260211%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling PTK2 FGFR1 NFKBIA MAP2K2;MAP2K1 STAT3 SHC1-1 CSF1R KDR PDGFRB CSNK1A1 PDGFRA MDM2-2 GRB2 SOS1 FGFR3 CTNNB1 RETN SOS2 TELO2 FGFR4 MET ELK1 TTI1 FLT4 FGFR2 RAF1 JUN NFKB1 LEF1 IL6 PTEN NFKBIE PPARD WNT1 REL ULK2 IKBKG EGFR GSK3B PIK3CD IL6R PIK3CB FLT1 PML RPTOR FOS DEPTOR TEK CHUK IGF1R MLST8 NGFR CDKN1A AKT2 MYC KSR1 AKT3 AXIN2 GAREM2 MAPK1 AKT1 PIK3CA MAPK3 FLT3 INSR EPHA2 FZD6 RUNX1T1 BRAF FOXO1-1 ZBTB16 PYGO1 BCL9 RARA LRP5 RHEB KRAS PIK3CG AKT1S1 LRP6 NTRK1 NTRK2 SALL4 IKBKB JAK2 KIT MTOR JUP APC HRAS TP53 CCND1 SRC TSC2 TSC1 RELA INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260211%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition RPS6KB1 IRS1 AKT2 SLC2A4 INSR MTOR RPS6 TBC1D4 MELANOMA%WIKIPATHWAYS_20260211%WP4685%HOMO SAPIENS Melanoma EXOC7 NRAS MAP2K2;MAP2K1 KDR MDM2-2 GRB2 SOS1 MITF SOS2 SHC2 PIK3R3 GADD45A CDKN2A CDH1 RAF1 NF1 GRM3 CTTN RHOB PTEN CALML6 ARAF RHOC CALML3 CALML4 RAC1 CALM1 CALM2 ERBB4 E2F2 DDB2 PAK1 E2F1 PIK3CD PIK3R2 PIK3R1 BAK1 PIK3CB GRIN2A GADD45B GADD45G CDKN1A AKT2 AKT3 PDE5A POLK MAPK1 AKT1 PIK3CA MAPK3 RHOA BRAF BAX CDK4 KRAS VCL BAD STK19 KIT PREX2 RB1 HRAS CDK6 E2F3 TP53 CCND1 CALM3;CALM1 PTPN11 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260211%WP5293%HOMO SAPIENS Acute myeloid leukemia CD14 NRAS MAP2K2;MAP2K1 STAT3 CSF1R PIM1 PIM2 BCL2A1 GRB2 SOS1 SOS2 PIK3R3 STAT5A STAT5B PER2 RPS6KB2 SPI1 RAF1 NFKB1 LEF1 TCF7 GLI1 TCF7L2 TCF7L1 ARAF PPARD CEBPA IKBKG RUNX1 CSF2 PIK3CD PIK3R2 PIK3R1 PIK3CB PML CHUK CCNA2-1 AKT2 MYC AKT3 MAPK1 AKT1 PIK3CA MAPK3 FLT3 CCNA1 ITGAM RUNX1T1 BRAF ZBTB16 RARA RPS6KB1 IL3 DUSP6 KRAS IKBKB BAD KIT MTOR CEBPE JUP HRAS FCGR1A MPO CCND1 EIF4EBP1 RELA GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260211%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR CEP19 MIB1 DYNC2H1 DYNLT1 DYNLT2B DYNC2LI1 RABL2A;RABL2B CEP43 TULP3 TRAF3IP1 IFT52 TMEM107 BBS9 CEP120 BBS7 IFT57 BBS5 KIAA0753 TCTN3 TCTN2 BBS4 OFD1-1 TCTN1 CEP97 MKKS CC2D2A IFT140 ARMC9 IFT80 CEP20 RPGRIP1L WDR35 LZTFL1 EVC BBS10 IFT43 PIBF1 BBS12 CPLANE1 TMEM216 TMEM231 WDPCP TMEM17 CILK1 CEP104 ARL6 B9D1 ARL3 ARL13B TMEM67 INPP5E EVC2 BBS2 BBS1 WDR19 SCLT1 IFT172 IFT122 HSPB11 FUZ IFT74 TXNDC15 TTC8 CDK20 MKS1 TRAPPC11 KIFAP3 CEP192 TEDC1 CLUAP1 TEDC2 FBF1 TTBK2 KIF3B CEP76 CPLANE2 SASS6 CEP83 CIBAR1 TTC23 C2CD3 CBY1 EFCAB7 CEP295 IFT81 KATNB1 TUBD1 TUBE1 CEP162 IFT27 CEP44 TTC21B IFT88 TTC30A;TTC30B IFT20 TTC26 RAB23 IFT46 DYNC2I2 DYNC2I1 KIF3A COPPER HOMEOSTASIS%WIKIPATHWAYS_20260211%WP3286%HOMO SAPIENS Copper homeostasis SCO1 SOD3 SLC31A2 COMMD1 GSK3B MT3 ATOX1 MTF1 STEAP1 MTF2 STEAP2 MDM2-2 ADAM10 XIAP COX17 CASP3 STEAP3 MT2A AKT1 PIK3CA COX11 FOXO1-1 ADAM9 SOD1 STEAP4 SLC11A2 CCS ADAM17 JUN APC SP1 BACE1 TP53 APP PTEN CCND1 FOXO3 MAPT PRNP ATP7B SLC31A1 ATP7A NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260211%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence NMNAT2 SLC2A4 SIRT2 GOT1-1 GOT2-1 IL6 ELAVL1 SIRT5 SLC2A1 SIRT1 TP53 PARP1 NAMPT CCL27 IL1B G6PD SIRT3 PRKAA1 MDH1 MDH2 RELA HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260211%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBG2;HBG1 LDB1 HBA2;HBA1 LMO2 GATA1 TAL1 HBZ HBD;HBB RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260211%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer FANCG SIN3A CDC25A RRM1 TOP2A SKP2 CDC25B SUV39H1 MSH6 DHFR2;DHFR HMGB1-1 MDM2-2 RRM2-1 SMC2 KIF4B;KIF4A NPAT ORC1 HLTF PLK4 TYMS RABIF ABL1 CDC7 CCDC6 BARD1 MCM7 MCM3 DCK MCM6 TTK CDC45 MCM4 RAF1 CCNE1 MAPK13 RBP1 ZNF655 POLA1 TFDP1 DNMT1 RBBP4 CDT1 PRIM1 CDKN1B CCND3 E2F2 SMC1A STMN1 CCNE2 E2F1 HDAC1 CCNB2 CCNB1 ANLN RFC3 SMARCA2 RFC4 RPA2 FAF1 WEE1 CCNA2-1 CDKN1A SMC3 CDK1 MYC RPA3 RBBP7 RPA1 POLD3 POLE CDK4 CDK2 PCNA POLE2 RB1 H2AZ2;H2AZ1 SAP30 CDK6 E2F3 TP53 PRMT2 CCND1 PRKDC CHEK1 HMGB2 RFC5 TFDP2 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260211%WP4271%HOMO SAPIENS Vitamin B12 disorders CBLIF MMAB TCN2 TCN1 MTRR MTR-1 MMUT CUBN AMN MMAA MMACHC MMADHC CD320 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy FGFR1 FGF23 FOSB PRKCA STAT3 COL1A1 VHL JUND KDR CCN2 FGFR3 COL10A1 IBSP FGFR4 GANC DDR2 HIF1A CNMD P4HTM JUNB FOSL2 FOSL1 RUNX2 FGFR2 JUN NFKB1 MMP13 NGF CEBPB SPP1 RELB FOS VEGFA AKT2 ARNT AKT3 MAPK1 AKT1 PIK3CA MAPK3 EPAS1 NTRK1 JAK2 COL2A1 LAMTOR1 ACAN SOX9 COL3A1 RELA GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism HEXA ST8SIA6 ST8SIA1 ST3GAL4 B3GALT4 ST3GAL5 ST8SIA5 ST3GAL1 ST3GAL2 B4GALNT1 NEU3 HEXB NEU4 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260211%WP5461%HOMO SAPIENS Primary ovarian insufficiency CLPP WRN XRCC4 LIG4 PCCA FOXL2 PCCB NOTCH2 NR5A1 WT1 DCAF17 AMH HSD17B4 HSD17B1 LARS2 LGR4 ZAR1 LMNA FMR1 PGRMC1 PPM1B TP63 EXO1 ATG9A PRDM1 SALL4 SLX4 FANCM FANCL XRCC2 FANCA FANCC BMPR1B RFWD3-2 BMP6 GNAS-1 AR BLM CYP19A1 FSHR LAMC1 NUP107 ERAL1 ESR1 AMHR2 PRORP RCBTB1 SOX8 EIF4ENIF1 MEIOSIN POF1B ATM MEIOB SIL1 CYP17A1 HFM1 SOHLH2;CCDC169-SOHLH2 BMPR1A NANOS3 PREPL MSH4 NOBOX BMPR2 KHDRBS1 AARS2 AIRE SYCP2L WDR62 HMMR BRCA2 STRA8 SYCE1 EIF2B5 ANTXR1-1 SOHLH1 KASH5 SWI5 COX10 HELQ ESR2 HARS2 EIF2B1 DIAPH2 H1-8 EIF2B4 HROB BNC1 LHX8 NBN MCMDC2 MCM8 POLR3H PMM2 MCM9 EIF2B2 ELAVL2 BMP15-1 POLG C1orf146 GALT MRPS22 TWNK SGO2 SPIDR FANCI C14orf39 CPEB1 HAX1 STAG3 PSMC3IP NUP43 MLH1 SHOC1 CCDC185 MGME1 RAD51 MND1 CENPE XPNPEP2 SPATA33 ERCC6 TGFBR3 ALOX12 MST1R ZP3;POMZP3 FIGLA DAZL GDF9 MSH5 DMC1 CAV1 POLR2C ATG7 STAR SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260211%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence PRKCB PRKCA ASAH1 E2F1 GBA SGMS2 UGCG SPTLC1 KDSR CERS4 CDKN1A GLB1 SPHK1 MAPK1 SMPD3 SGPP1 DEGS1 CERS2 CDK4 CDK2 S1PR1 MTOR RB1 S1PR2 S1PR5 TERT RPP38 PLCB1 MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CDC25A CCNE1 ATM E2F1 CDK6 TP53 RAD52 CREB1 CCND1 CDKN1A ABL1 MYC CDKN1B CCND3 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP2369%HOMO SAPIENS Histone modifications H3-3A SUV39H2 SUV39H1 SMYD1 AEBP2 SET-1 KMT2E EZH1 SETD4 SMYD2-1 KMT2D SETD5 SETD3 SMYD5 EHMT2 SETD9 EHMT1 SETD6 KMT2B DOT1L SETD7 SETD2 PRDM2 KMT2C SMYD4 KMT5B SMYD3 KMT5A SETDB1 KMT5C SETD1B H4-16 SETD1A SETMAR ASH1L SETBP1 EED NSD1 H4C1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H4C6 KMT2A EZH2 MIRNA BIOGENESIS%WIKIPATHWAYS_20260211%WP2338%HOMO SAPIENS miRNA biogenesis RAN XPO5 DGCR8 DICER1 DROSHA TARBP2 BLADDER CANCER%WIKIPATHWAYS_20260211%WP2828%HOMO SAPIENS Bladder cancer NRAS MAP2K2;MAP2K1 EGFR E2F1 PIK3R2 PIK3R1 MDM2-2 VEGFA FGFR3 RASSF1 CDKN1A MYC CXCL8 MAPK1 MMP9 CDKN2A BRAF DAPK1-1 EGF CDK4 MMP2 KRAS HBEGF CDH1 RAF1 RB1 HRAS RPS6KA5 TP53 DAPK2 SRC CCND1 DAPK3 ARAF UPK3A THBS1 ERBB2 MMP1 TYMP MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260211%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma VEGFB VEGFC HEY1 HIF1AN HIF1A HES1 VEGFA MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260211%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX20 COX15 SURF1 COX17 COX6A1 COX7A2 COX6B1 COX11 COX7B COX4I1 COX7C COX8A COX5A NDUFA4 COX5B COX19 COX18 TACO1 HIGD1A COX6C PET117 COA3 COX14 COX10 CMC1 TMEM177 PNKD SMIM20 PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260211%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway SEPTIN2 RACGAP1 RAB35 AFAP1 KIF23 RDX MSN OCRL EZR RHOA ANLN MYL2 EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260211%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects CXCL12 RGS16 PRL MYB KLF2 ERBB4 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome SEPTIN2 RRAGC DGKD ARF1 HDLBP DISC1 HJURP ERFE KLHL30 SEPTIN4-1 PASK THAP4 RRAGB FARP2 RRAGD AGAP1 COPS9-1 ESPNL TRPM8 MEF2A OR6B2 MTERF4 CYTH3 MEF2C RAB27A STK25 SNED1 RTP5 GMEB1 RNPEPL1 CALCRL SEPTIN12 MYOG ING5 LRRFIP1 KIF1A ILKAP AQP12B DUSP28 OTOS ARL4C PER2 ATG4B USP40 ARF5 ASB18 GBX2 MYOD1 CENPA CYTH2 CYTH4 SPP2 D2HGDH PRLH CYTH1 HES1 SEPTIN6 IRF8 MAB21L4 MLPH HAMP CAPN10 RAB17 RBM44 ASB1 TRAF3IP1 ILK GPR35 CXCL11 PDGFA MYO5A COL6A3 GABARAPL2 TRAF3 GPC1 PDCD1 RPS6 PDX1 NEU4 PRL IL13RA1 TWIST2 SCLY HES6 NFKBIA CXCR4 ITGB3 GABARAP CALCA UBE2F TNF PPP1R7 AGXT ASCL1 JUN DTYMK CALM1 RAC1 CFLAR ACKR3-2 NDUFA10 EGFR EEF1A1 BOK RRAGA CXCL12 GYS1 IQCA1 IL1B MAP1LC3A HDAC4 MAP1LC3C MAP1LC3B2;MAP1LC3B-1 COPS8 UGT1A1;UGT1A6 ITPK1 SH3BP4 TP53 RAMP1 ABCA1 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260211%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition SIX1 SUZ12 TGFB1 ELF5 CDH1 SUV39H1 SNAI1 SNAI2 HDAC1 KDM1A SIRT1 TCF4 ZEB1 HDAC2 PRRX1 GRHL2 KLF8 FOXC2 GSC2 ELF3 ZEB2 EZH2 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260211%WP2878%HOMO SAPIENS PPAR alpha pathway ACAA1-1 NR1H3 CYP7A1 APOA5 CDK4 SCP2 KLK15 CPT1A EHHADH-1 APOA2 PPARA CYP8B1 APOA1 FABP1 CCND1 RXRA CPT2 CDK1 MYC ACADM SLC27A1 APOC3 PLTP TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260211%WP691%HOMO SAPIENS Tamoxifen metabolism CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FMO1 CYP1A1 CYP2D6;LOC107987479;LOC107987478-1 FMO3 CYP2E1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2A1-4 CYP1A2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP1B1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260211%WP474%HOMO SAPIENS Endochondral ossification FGFR1 TGFB2 GLI3 TGFB1 CHST11 BMP6 CDKN1C ADAMTS5 FGFR3 COL10A1 MEF2C TIMP3 BMP7 MMP9 ALPL DDR2 STAT5B RUNX2 PTH SOX6 SOX5 PLAU PTHLH BMPR1A MMP13 ADAMTS1 CTSV;CTSL GHR PTH1R SERPINH1 CALM1 ADAMTS4 FRZB NKX3-2 SCIN MGP SPP1 PRKACA-1 IGF2 SLC38A2 STAT1 VEGFA IFT88 IGF1R HMGCS1-1 HDAC4 AKT1 CAB39 IGF1 THRA COL2A1 IHH PLAT RUNX3 ACAN ENPP1 PTCH1 SOX9 FGF2 FGF18 KIF3A ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260211%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase EPHX2 GSTP1 CYP2J2-1 COX8A CYP2C9;CYP2C19 COX5A PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260211%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases BUB3 PKM H3-3A STAT3 SNAP23 KHK AKT1S1 PRPS1 MYL2 PGK1 PDK1 BECN1 PAK2 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260211%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 GLI2 INHBA EDAR PDGFRA PDGFA TP63 CTNNB1 FZD1 CCND2 MYC BMP4 SHH WNT5A LRP5 RUNX2 ITGB1 FGFR2 CDH1 NFKB1 SNAI1 LEF1 LAMA5 GLI1 FGF1 PTCH1 CCND1 NCAM1 FOXI3 EDA GTPBP4 SMO GJB6 ERYTHROPOIESIS%WIKIPATHWAYS_20260211%WP5607%HOMO SAPIENS Erythropoiesis GDF11 IL3 CD34 HBA2;HBA1 GATA2 CD79A EPOR KIT TF GATA1 HBZ PTPRC HBG2;HBG1 FAS KITLG FASLG EPO HBD;HBB TFRC IL3RA ANGIOGENESIS%WIKIPATHWAYS_20260211%WP1539%HOMO SAPIENS Angiogenesis MAPK14 PTK2 PLCG1 FGFR2 ANGPT1 KDR PDGFRA FLT1 VEGFA TEK CREBBP NOS3 SRC ARNT TIMP2 SMAD1 MAPK1 TIMP3 MMP9 AKT1 PIK3CA PDGFB FGF2 HIF1A BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260211%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome PRKAG1 MAPK10 PRKAG2 G6PC2 MAPK9 MAPK8 PRKAA2 SLC27A2 PRKAG3 G6PC3 PRKAB2 MAPK1 PRKAB1 MAPK3 PRKAA1 CRP ACACB MAPK14 ACLY MAPK12 MAPK13 MAPK11 ACACA G6PC1 PCK2 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260211%WP4316%HOMO SAPIENS miRNA degrading enzymes EXOSC4 XRN1 PNPT1 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260211%WP4753%HOMO SAPIENS Nucleotide excision repair CETN2 RFC2 XPA XPC RFC1 POLE4 RAD23A ERCC4 GTF2H2C;GTF2H2C_2;GTF2H2 ERCC5;BIVM-ERCC5 ERCC1 CCNH DDB2 ERCC8 GTF2H1 GTF2H3 GTF2H4 ERCC2 RFC3 ERCC3 RFC4 RBX1 MNAT1 RPA2 RPA3 ERCC6 RPA1 POLD3 POLD4 RAD23B POLD1 POLE CDK7 LIG1 PCNA CUL4A POLE2 POLE3 DDB1 CUL4B POLD2 RFC5 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260211%WP5061%HOMO SAPIENS Fatty acid transporters ACSL1 ACSL6 ACSL5 ACSL4 ACSL3 FABP9 FABP3 FABP4 ACSBG1 FABP5 ACSBG2 FABP7 FABP1 FABP6 SLC27A4 CD36 FABP2 GLYCINE METABOLISM%WIKIPATHWAYS_20260211%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 MTHFR SHMT2 COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260211%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CCL13;CCL2 TMPRSS2 IL2RA IL6 IL7 AGT ACE2 IL10 IL2 IL1B CSF3 CXCL8 TNF CXCL10 CCL3L1;CCL3L3;CCL3;CCL18 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260211%WP3298%HOMO SAPIENS Melatonin metabolism and effects ASMT AANAT ADRB1 PRKCA TPTEP2-CSNK1E;CSNK1E GSK3B CYP2C9;CYP2C19 ACHE CYP2D6;LOC107987479;LOC107987478-1 SIRT1 APOE ARNTL EDN1 CRY2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CRY1 ECE1 TRAF6 FOXO1-1 CAMK2A MAP2 PER2 PER1 NFKB1 CYP1A1 MAOA CLOCK MTNR1A MTNR1B CALM1 CYP1A2 CYP1B1 IRAK1 CSNK1D KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260211%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary PRKCB ARRB1 PRKCE HSD3B1;HSD3B2 NRAS PRKCD ARRB2 CYP11A1 MAP2K2;MAP2K1 PRKCA BMP15-1 PIK3CD PIK3CB KISS1R KISS1 PRKCQ FSHR PLCB3 AKT2 AMH MAPK1 AKT1 MMP9 MAPK3 PIK3CA GDF9 KRAS PIK3CG RAF1 NFKB1 HRAS PLCB4 PRKCG PLCB1 PLCB2 PDK1 PRKCH STAR THERMOGENESIS%WIKIPATHWAYS_20260211%WP4321%HOMO SAPIENS Thermogenesis PRDM16 PNPLA2 FRS2 GRB2 GCG SOS1 RPS6KA3 SMARCD1 MAP2K3 SMARCD2 SMARCD3 MAPK12 MAPK13 MAPK11 SMARCC1 SMARCC2 ARID1B PRKAA2 SMARCA2 BMP8A;BMP8B RPTOR SLC25A29 BMP8B MLST8 PRKG2 CREB3L3 CREB3L4 CREB3L1 ACTL6A RPS6 PRKAA1 RPS6KB1 RHEB KRAS RPS6KA1 AKT1S1 ATF2 RPS6KA2 CREB3L2 HRAS ACTG1 ARID1A TSC2 TSC1 FGFR1 NRAS GNAS-1 ADCY9 FGF21 SOS2 MAP3K5 SMARCA4 CNR1 RPS6KB2 SMARCB1 KDM3A ACTB-1 KDM1A CREB5 PRKACA-1 PRKAG1 PRKAG2 SLC25A20 PRKAG3 LIPE CREB3 PRKG1 CREB1 PRKAB2 CPT2 CPT1C PRKAB1 CPT1B MAPK14 ACSL1 ADCY4 KLB ADCY10 ADCY3 ACSL6 ADCY2 ACSL5 ADCY1 ACSL4 ADCY8 ACSL3 ADCY7 ADCY6 DPF1 ADCY5 CPT1A PRKACB-1 DPF3 MTOR SMARCE1 RPS6KA6 ACTL6B SIRT6 PPARGC1A PPARG ADRB3 ZNF516 PLIN1 MGLL KDM3B NPR1 UCP1 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy DGAT2 DGAT1 ITGB4 CAV1 LPIN1 LPIN2 GRB2 LPIN3 CAVIN1 INS;INS-IGF2 GPAT3 BSCL2 IRS1 AKT2 AGPAT2 PIK3CA HIF1A FYN WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP4149%HOMO SAPIENS White fat cell differentiation SREBF1 CEBPA DDIT3 CEBPB RORA EGR2 CEBPD GATA3 GATA2 KLF15 KLF2 KLF5 ZNF423 TLE3 IRF3 INS;INS-IGF2 MECOM CREB1 WNT10B KLF4 FOXO1-1 STAT5A NR1H3 STAT5B RARA IRF4 TCF7L1 EBF1 NR2F2 PPARG NR3C1 CTNNA1 ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260211%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma PRKACA-1 GNAS-1 MYL4 ADCY9 PRKAR1B PRKAR1A MYL2 PLCB3 CREB1 ADRB2 PRKAR2A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 MYL1 PLCB4 NR3C1 PLCB1 PLCB2 MYL3 STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260211%WP4463%HOMO SAPIENS Steroidogenic pathway HSD3B1;HSD3B2 CYP11A1 HSD17B1 CYP17A1 STAR CYP19A1 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260211%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta MBTPS1 COL1A1 COL1A2 P4HA2 ITPR1 FZD1 FKBP10 PLOD2 MIA3 CREB3L1 TMEM38B COLGALT1 IFITM5 MBTPS2 CRTAP SP7 P3H2 LOX PLOD1 P3H1 BMP1 ADAMTS2 LRP5 P4HA1 LRP6 TNFSF11 TNFRSF11B SERPINF1 PPIB SERPINH1 P4HB WNT1 TNFRSF11A SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260211%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides A4GALT CERS2 DGAT1 DES ASAH1 CERK B4GALT1 SGMS1 CERS5 SGMS2 UGT8 UGCG SPTLC1 A3GALT2 KDSR CERS3 CERS4 CERS6 SPHK1 B4GALNT1 B3GNT5 CERS1 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260211%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination WNT4 MAP3K4 FGFR2 GSK3B MAPK11 FOXL2 GADD45G CTNNB1 AXIN1 FGF9 SRY SOX9 MAPK1 MAP3K1 RHOA ROCK1 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260211%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A4 SLC6A6 SLC15A2 CARNS1 HEROIN METABOLISM%WIKIPATHWAYS_20260211%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260211%WP5174%HOMO SAPIENS Ulcerative colitis signaling TGFB1 NOD2 IL2RG GATA3 HLA-DMA NFKB1 TLR2 STAT6 IFNG IL10 IL4R IL13 NFATC1 MAF FOXP3 IL4 IL5 TNF IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260211%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease STAT5A IL22 STAT5B RORC TLR4 STAT3 TYK2 IL12B CSF2 STAT4 JAK2 STAT1 IL12RB1 IFNG IL23A IL17F IL17A TNF ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway MAP3K12 FLOT1 MAPK10 FLOT2 CAP1 MAPK9 MAP4K1 MAPK8 MAP4K2 MINK1 SOS1 RHOQ MAP4K5 MAP4K3 MAP4K4 MAP3K2 MAP3K1 PIK3R3 NR1H3 RPS6KA3 MAP3K9 MAP3K4 MAPKAP1 MAP2K3 MAP2K4 MAPK12 MAPK13 MAPK11 MAP3K10 MAP3K11 FASN PCK1 SREBF1 PIK3R4 PIK3R2 PIK3R1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PRKAA2 RPTOR MAP2K5 MLST8 MAP3K14 INS;INS-IGF2 AKT2 ANGPTL8 MAPK1 AKT1 MAPK3 INSR ABCG8 CRK PRKAA1 ABCG5 FOXO1-1 SCD CYP7A1 SESN3 MAPK7 TRIP10 RPS6KB1 RHEB MAP3K3 RPS6KA1 PIK3CG RPS6KA2 HRAS EIF4EBP1 TSC2 TSC1 PTPN1 PIK3C2G EXOC7 PIK3C2A MAP2K2;MAP2K1 SHC1-1 PDPK1 MAPK6 MAPK4 IRS1 IRS4 SOS2 IRS2 SHC2 SHC3 MAP3K5 EIF4E RPS6KB2 RAF1 LPL MAP3K13 SREBF2 FBP1 GSK3A G6PC1 RXRA MAP2K7 CYP2B6 GSK3B PRKAG1 PRKAG2 PIK3CD SLC2A4 PIK3CB PRKAG3 GYS1 SLC2A1 PRKAB2 PRKAB1 PIK3CA PIK3C3 MAP2K6 RAPGEF1 MAPK14 THRB THRA MTOR CBLC CBLB SLC16A2 RPS6KA4 RPS6KA6 RPS6KA5 MAP3K8 MAP3K6 FOXO3 SLCO1C1 MAP3K7 CBL RICTOR CILIARY LANDSCAPE%WIKIPATHWAYS_20260211%WP4352%HOMO SAPIENS Ciliary landscape H3-3A ECHS1 PSMD8 CTBP2 PAFAH1B1 PSMD7 TFAP2E;TFAP2B PSMD12 CDR2 NEFL NDUFA9 PSMD13 NEK7 MCM10 POM121;POM121C SSNA1 PSMC6 ARHGDIA PSMC4 CEP97 ANKS6 TFAP2A IQGAP3 DYNC1H1 YAP1-1 GLA RAB8A IFT172 HSPB11 DOCK5 IFT74 RAB2A EXOC8 IFT81 EXOC7 EXOC4 EXOC3 IFT27 EXOC6 EXOC5 EXOC2 EXOC1 MFAP1 MCM7 MCM3 MCM5 MCM6 MCM4 NFKB1 VIM CALM1 EIF5B MCM8 MCM9 HDAC1 RAB14 CBS;CBSL CAMK2A STOM ACSL3 NDUFA5 TFAP2C RANBP9 MYL6 DYNC2I2 DYNC2I1 AFG3L2 HTRA2 DYNLT1 TBC1D4 DYNLT2B LRPPRC GLB1 XPNPEP3 DYNLRB2 DYNLRB1 CREBBP HDAC2 TRAF3IP1 EFTUD2 DDX5 IFT52 BBS9 BBS7 EXOSC4 IFT57 BBS5 CEP290 BBS4 IQCB1 IFT140 IFT80 CD2BP2 LZTFL1 IFT43 EFHC2 SMC4 DCAF7 BBS2 INTU NEK8 COPS7B BBS1 NUP88 AAR2 CTSA EXOC6B LCA5 AIMP1 IFT122 EHD3 WNK1 FUZ RB1 RANBP10 MYL6B TTC8 MKS1 TNKS1BP1 TMED1 NUDC CNOT6L CLUAP1 EIPR1 RAB3IL1 NME8 MAPRE2 DYNC1LI1 EXOSC7 PGRMC2 EXOSC9 EXOSC2 WHRN UBE2D3;UBE2D2 TIPRL-2 GID8 YPEL5 DGKE APMAP ERF ARL8B SPATA7 CDH23 SNRPB2 UBE2H TFAP2D MCM2 RHBDD2 UQCC1 CNOT10 MSH2 LSM4 CNOT1 RNGTT LCN2 ZMYND19 RPGR RBM14 NUP133 ARFGAP3 CTNNB1 RABEP2 CCDC40 VPS4A EHBP1 RAB21 RMND5B DNPEP DCAF11 VAPB BBIP1 DYNC1I2 GDI1 RAC1 AGPAT2 DVL3 MAEA ARMC8 IFT88 TTC30A;TTC30B CNOT9 WEE1 COPS7A NEFM COPS4 SNAP29 IFT20 COPS3 COPS6 IFT22 COPS5 COPS2 COPS8 IQGAP1 TTC26 APC IQGAP2 USH1C ZYG11B IFT46 WDR26 RALB RMND5A COX6C MKLN1 GID4 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260211%WP5175%HOMO SAPIENS Disorders in ketone body synthesis HMGCL BDH1 OXCT1-1 HMGCS2 ACAT1 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PIK3C2G PIK3C2A PARP2 PIK3C2B IKBKG GSK3B PIK3R4 PIK3CD PIK3R2 PIK3R1 PIK3CB RPTOR SIRT1 PHLPP1 MLST8 AKT2 AKT3 AKT1 PIK3R3 PIK3CA PARP3 FOXO1-1 MAPKAP1 PIK3CG ATM MTOR STK11 PARP1 PIK3R6 PIK3R5 RICTOR TSC2 PDK1 TSC1 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260211%WP5093%HOMO SAPIENS Opioid receptor pathways PIK3CG TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260211%WP1471%HOMO SAPIENS Target of rapamycin signaling RRAGC ULK2 PRKCA ULK1 PRKAG1 PRKAG2 PRKAA2 RRAGB IDI1 RRAGD PRKAG3 RPTOR RRAGA MLST8 FKBP1A PRKAB2 AKT1 PRKAB1 DDIT4 DDIT4L PRKAA1 ULK3 PRR5 MAPKAP1 RPS6KB1 RHEB PRR5L AKT1S1 MTOR CDC42 HMGCR RAC1 EIF4EBP1 RICTOR TSC2 TSC1 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260211%WP4217%HOMO SAPIENS Ebola virus infection in host HAVCR2 CLTC NFKB2 CLTA HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E GSN FLNB PIK3R3 BST2 HLA-DRA RHOB CREBBP RHOC SCIN TPCN2 IKBKE EP300 TYRO3 REL RELB TBK1 DDX58 PIK3R2 TIAM1 PIK3R1 NEDD4 TFAP2A IRF3 RASA2 IGF1R VPS11 VPS39 NPC1-1 VPS16 ITGA1 VPS18 MAPK1 AKT1 MAPK3 VPS33A RHOA TOP1 CTSB PRKRA EIF2AK2 TLR4 ITGB1 RAB7A VPS41 ACTG1 VAV2 NPC2 SOCS3 ACTN4 FLNA RELA RAB9A ITGB3 ICAM2 GAS6 VPS4A C1QBP IRF7 ITGA2 ICAM3 HLA-DOA HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 HLA-DOB KPNA1 TIMD4 AXL CLEC4G MBL2-1 ADAM17 TSG101 MFGE8 CLEC6A HLA-DPB1-1 ASGR1 NFKB1 HLA-DPA1 ITGAV HLA-DQB2;HLA-DQB1 HLA-DMB DAB2IP FOLR1 ITGA3 ACTB-1 FLNC CTSV;CTSL CAV3 RAC1 ITGA6 ITGA5 CLEC4M;CD209-2 EIF2S1 RFC1 EGFR HLA-DMA PAK1 PIK3CD PIK3CB STAT1 CAV2 IL4 PIK3CA ACTN1 CLTB IQGAP1 RAB5A CAV1 ITGA4 CDC42 EPS15 MERTK CLTCL1 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260211%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart PRKCB MAPK14 MYEF2 PRKCE NFATC4 MAP2K3 STAT3 JUN MAPK11 CTF1 PPP3CA MAPK8 PPP3CB AGT FOS IL6ST GATA4 EDN1 MAPK1 RAC1 CALM1 CAMK2D RHOA LIFR FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP143%HOMO SAPIENS Fatty acid beta oxidation HADHA PNPLA2 HADHB-1 ACADVL ECI1 ACADL ECHS1 SLC25A20 ACADS ACAT1 CHKB GK LIPE ACSS2 CPT2 ACADM DECR1 HADH GPD2 CPT1B ACSL1 ACSL6 ACSL5 ACSL4 ACSL3 LPL CPT1A DLD GCDH GK2 LIPF CRAT LIPC TPI1 GASTRIN SIGNALING%WIKIPATHWAYS_20260211%WP4659%HOMO SAPIENS Gastrin signaling BCAR1 STAT3 MAPK9 MAPK8 YES1 GRB2 SOS1 MEF2C PXN KLF4 MEF2D MEF2B;BORCS8-MEF2B PIK3R3 ELK1 MMP7 MAP3K11 RHOB HDC TCF4 BMP2 RHOD TJP1 PTGS2-2 PIK3R2 PIK3R1 CDKN1A KAT5 MYC MAPK1 AKT1 MAPK3 RHOA RPS6 CRK FOXO1-1 ROCK1 CLDN1 RPS6KB1 ITGB1 KRAS ATF2 IKBKB JAK2 KIT HRAS CCND1 SRC EIF4EBP1 JAG1 PRKCH FYN RELA PTPN11 PTK2 NFKBIA PRKCE PRKCD PRKCA MAP2K2;MAP2K1 SHC1-1 PRKCQ PRKD1 SERPINB2 ANXA2 CCKBR CTNNB1 IRS1 CDKN2A PLCG1 CDH1 RAF1 JUN CD44 LAMTOR3 NFKB1 SP1 BIRC5 GNAQ ARHGEF28 GAST CHGA RAC1 CDKN1B ARRB1 ARRB2 EGFR PRKACA-1 GSK3B PAK1 ELAVL1 FOS VEGFA CASP3 CHUK IL2 CREB1 CXCL8 SLC9A1 PIK3CA HDAC7 BIRC2 BIRC3 MAPK14 SLC9A3 BCL2L1 BAD SERPINE1 MTOR CDC42 PPARG FOXO3 EGR1 PRKD2 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260211%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer CREB1 SIK3 SIK2 PRKACA-1 GNAS-1 HDAC4 HDAC5 DNAJB1 SIK1;SIK1B CRTC2 HDAC7 MACROPHAGE MARKERS%WIKIPATHWAYS_20260211%WP4146%HOMO SAPIENS Macrophage markers CD14 CD163 CD74 CD83 LYZ-1 CD68 F3 CD86 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer NRAS ULK1 GSK3B PIK3R2 PIK3R1 PIK3CB RPTOR RB1CC1 MLST8 AKT1 PIK3R3 PIK3CA TFEB FOXO1-1 MAPKAP1 FOXO4 RHEB KRAS PIK3CG BAD MTOR HRAS GRB10 PTEN NOS3 FOXO3 CDKN1B EIF4EBP1 RICTOR TSC2 PDK1 ATG13 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260211%WP2596%HOMO SAPIENS Gastric acid production CBLIF GAST GRP PGA4;PGA3;PGA5 SCT PGC VIP MUC6 CCK MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260211%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 RAC3 PIK3C2A NCKAP1L PTPN6 PIK3CD PIK3R2 PIK3R1 PIK3CB NCF1 NCF4 C1QC FCER1G PIK3R3 CYBA PIK3CA PIK3C3 ITGAM SYK HCK NCF2 ITGB2 PLCG2 CYBB LYN TREM2 TREM1 PIK3CG FCGR1A VAV1 VAV2 VAV3 LAT TYROBP PIK3R6 RAC1 C1QB ARPC1B MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260211%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation SIX4 STK11 PTBP1 CTDSP1 STRADB PRKAA1 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260211%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells SLC2A1 PDP1 PKM LDHA SLC16A1 PFKP HK1 PDK1 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation PTK2 WDR45B PTK2B ATG16L1 ULK1 RB1 RB1CC1 GABARAP TP53 TRAF2 ATG101 TNF GABARAPL2 ATG13 MAP3K5 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260211%WP5130%HOMO SAPIENS Th17 cell differentiation pathway NFKBIA TGFB1 STAT3 CD4 MAPK8 SMAD2;SMAD3 PRKCQ ARNTL NFIL3 HIF1A STAT5A PER1 PLCG1 JUN IL27 TYK2 NFKB1 HSP90AA1 IL6 IRF4 LAT RXRA JAK1 IL21 IL22 IL23R RORC RORA IL27RA RUNX1 GATA3 HLA-DMA TBX21 IL6R IL21R STAT6 STAT1 IFNG CD3G IL23A IL4R FOS CD247 TGFBR1-1 CD3E IFNGR1 IL17F CD3D NFATC1 FOXP3 IL2 IL1B IL4 IL17A MAPK1 CRY1 MAPK14 RARA LCK IL2RA IKBKB JAK2 PPP3CA MTOR CLOCK AHR ZAP70 SOCS3 NR1D1 VISUAL CYCLE%WIKIPATHWAYS_20260211%WP5534%HOMO SAPIENS Visual cycle RDH8 OPN1SW RDH12 ABCA4 LRAT RBP3 RDH11 RBP1 RDH5 RHO OPN1MW3;OPN1MW2;OPN1MW;OPN1LW RDH10 RPE65 RLBP1 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260211%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260211%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PIK3C2G MTMR6 PIK3C2A MTM1 PIP5K1A PIK3C2B PIP5K1B PIP5K1C INPP4B PIKFYVE PI4K2B IPMK PIK3CD TPTE;TPTE2 PLCD3 FIG4 PLCD4 PIK3CB PI4KB PLCB3 PI4K2A PIK3CA PLCE1 INPP5K INPP5E INPP5D PLCG2 PLCG1 PIK3CG PIP4P2 PTEN PIP4P1 PIP4K2B PIP4K2C PLCB4 INPP4A SACM1L OCRL MTMR1 PLCB1 PLCD1 MTMR2 PI4KA PLCB2 PIP4K2A MTMR8 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260211%WP4842%HOMO SAPIENS Mammalian disorder of sexual development WNT4 FST RBFOX2 CBX2 DMRT1 DHH FOXL2 GATA4 CTNNB1 NR5A1 WT1 SRY RSPO1 AMH EMX2 AMHR2 SOX8 FGFR2 MAPK11 PTGDS PBX1 FGF9 SOX9 INSL3 SRD5A1 MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260211%WP4318%HOMO SAPIENS Mitochondrial fission and fusion FIS1 BAX MFN2 PLD1 BCL2L1 MIB1 DNM1L PHB MTFP1 MFN1 BNIP3 OPA1 SH3GL2 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260211%WP4628%HOMO SAPIENS Aerobic glycolysis augmented GPI PGAM2 PKM GAPDH-1 SLC2A1 GPT LDHA ALDOA PGK1 TPI1 ENO1 HK1 PFKM FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders FGF23 KL SLC34A1 SPP1 PTH FGFR2 ORAI1 NFKB2 NFKB1 FAM20C GALNT3 PHEX CYP11B1;CYP11B2 FGFR3 CYP27B1 ENPP1 CCND1 CDKN1A DMP1 ROS1 CYP24A1 ALPL EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260211%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol PCSK9 LDLR CHEMOKINE SIGNALING%WIKIPATHWAYS_20260211%WP3929%HOMO SAPIENS Chemokine signaling CCR6 BCAR1 STAT3 GRB2 SOS1 PXN STAT2 PIK3R3 CXCR6 CCR2 STAT5B CCL11 CX3CL1 CCR9 CCL5 CCR10 CCL23;CCL15 CCR1 XCR1 CCL19 CCL28 CCL4L2;CCL4L1;CCL4 CCR8 CCR4 CCL1 RASGRP2 IKBKG TIAM2 PIK3R2 TIAM1 PIK3R1 PARD3 CXCL11 RAP1B AKT2 AKT3 WASL MAPK1 AKT1 MAPK3 BRAF CRK ROCK1 ROCK2 GNG10 KRAS PIK3CG IKBKB JAK2 HRAS VAV1 VAV2 PLCB4 PIK3R5 CX3CR1 PLCB1 PLCB2 RELA PRKCB PTK2 NFKBIA CXCR4 PRKCD NRAS NFKBIB MAP2K2;MAP2K1 SHC1-1 ADCY9 RAP1A CCR7 CXCL9 CXCR5 SOS2 SHC4 PRKCZ ITK CXCL2;CXCL3;CXCL1-1 CXCL13 SHC2 CXCL14 SHC3 GRK2 CXCL10 GRK5 PF4;PF4V1-1 CCL3L1;CCL3L3;CCL3;CCL18 GRK4 XCL1;XCL2 GRK6 PPBP CXCR3 CXCR2 RAF1 NFKB1 GNG13 CCL17 GNB2 CCL25 CCL24 CCL20 CCL22 WAS CCL21 GNB1 GNB4 GNAI3 CCL27 GNB3 CCL26 GNB5 RAC1 GNAI2 FGR ARRB1 ARRB2 GNGT1 GSK3B PAK1 PIK3CD PIK3CB STAT1 NCF1 CXCL12 CHUK PREX1 ELMO1 PLCB3 GRK1 DOCK2 PRKX CRKL CXCL5;CXCL6 PIK3CA CCR3 GNAI1 HCK ADCY4 LYN ADCY3 ADCY2 PTK2B JAK3 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 GNG2 GNG5 GNG4 CDC42 GNG8 VAV3 FOXO3 CSK 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome TUBGCP2 TUBGCP5 NIPA1 TUBGCP6 TUBGCP3 CYFIP1 TUBGCP4 NIPA2 FMR1 NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260211%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer PTK2 TGFB2 BCAR1 TGFB3 MAP2K2;MAP2K1 NFKB2 COL1A1 KDR SMAD2;SMAD3 CCN2 HGF COL1A2 MET MMP9 NRP1 SMAD4 EGF MMP2 CHD2 CCNE1 NFKB1 SNAI1 SNAI2 GSK3A SEMA3A RAC1 CDKN1B TGFBR2 SLC39A4 REL RELB EGFR CCNE2 FLT1 VEGFA TGFBR1-1 AKT2 AKT3 MAPK1 AKT1 TGFBR3 MAPK3 CDH5 PLXNA1 PLXNA4 CDK2 PECAM1 CHD1 PLXNA2 SRC RELA ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer STAT3 GAB1 MAP4K1 MAPK8 SMAD2;SMAD3 GRB2 SOS1 KLK3;KLK2 PXN HSD17B4 CASP8 RASA1 HSD17B1 ELK1 SMARCD1 SMARCD2 SMARCD3 FOXA1 SMARCC1 SMARCC2 ARID1B F13B RPTOR RAP1B CDKN1A MYC MAPK1 AKT1 ACTL6A MAPK3 CRK BAX CDK4 RHEB CDK2 ATF1 RB1 HRAS MRE11 CCND1 ARID1A CHEK2 PRKDC CHEK1 EIF4EBP1 TSC2 TSC1 PTPN11 EIF4E1B CDC25A CDC25B MAP2K2;MAP2K1 MSH6 ETV4 AR MSH2 BLM MDM2-2 HGF RAP1A ERG BARD1 PLK1 CDKN2A SMARCA4 NOXA1 RAF1 JUN HSD17B7 ATM CYP17A1 SP1 ATR HSD17B2 CDKN2B PTEN BRCA1 JAK1 CPN1 SPRY2 CDKN1B MMP1 DOCK1 BCL2 HSD3B1;HSD3B2 FKBP5 PAK1 E2F1 STAT1 CASP9 FOS CASP3 RAD50 CDK1 HSD17B3 CRKL ABCC4 PIK3CA NDRG1 SPINK1 RAPGEF1 MAPK14 PTK2B SPRY1 BAD MTOR ACTL6B TP53 RICTOR SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260211%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis SREBF1 NR1H3 MED15 SREBF2 MTOR HMGCR SIRT1 FASN PPARA HMGCS1-1 SIRT6 PPARGC1A LDLR PRKAA1 ABCA1 SCD SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260211%WP4496%HOMO SAPIENS Signal transduction through IL1R IL1R1 NFKBIA TGFB2 TOLLIP TGFB1 TGFB3 MYD88 MAPK8 CHUK MAP3K14 IRAK3 IL1B IFNB1-4 IL1RN TNF MAP3K1 MAP2K6 TRAF6 MAPK14 MAP2K3 JUN NFKB1 TAB1 IKBKB IL6 IL1A MAP3K7 IL1RAP IRAK1 ECSIT RELA IRAK2 FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260211%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling CCR6 CCR5 STAT3 FLT3 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260211%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system XPO1 XPO4 EIF5A;EIF5AL1 IGF2BP1 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies BTK MS4A1 ITGB1 S1PR5 S1PR1 S1PR3 ITGA4 S1PR4 EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260211%WP410%HOMO SAPIENS Exercise induced circadian regulation PURA NCKAP1 CEBPB TAB2 HLA-DMA SF3A3 SUMO1 IDI1 GFRA1 PPP1R3C CBX3-1 HERPUD1 ARNTL CRY2 CRY1 UCP3 CLDN5 UGP2 VAPA PER2 NCOA4 PER1 DAZAP2 BTG1 PPP2CB;PPP2CA GSTP1 AZIN1-2 QKI TOB1 DNAJA1-1 STBD1 TUBB3;TUBB6 SUMO3 ERC2 RBPMS EIF4G2 ZFR KLF9 ETV6 MYF6 CLOCK H2BC15;H2BC3;H2BC11;H2BC12 PIGF G0S2 HSPA8 PSMA4 NR1D2 GSTM3 SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260211%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TOMM70 MAVS TBK1 IFNB1-4 DDX58 TRAF3 TRAF6 IKBKE IRF3 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260211%WP5390%HOMO SAPIENS Pancreatic cancer subtypes PRR15L DHRS9 LY6D TFF1 CLRN3 VGLL1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FGFBP1 SLC2A1 FAM83A AREG GPR87 TSPAN8 CDH17 CST6 CTSE TNS4 PLA2G10;LOC100652777 SPRR1A;SPRR1B SPRR3 S100A2 ST6GALNAC1 REG4 SERPINB3;SERPINB4-1 ANXA8;ANXA8L1 KRT20 LGALS4 KRT15 TFF3-1 CTSV;CTSL VSIG2 AGR2 LYZ-1 AGR3 FAM3D SPINK4 KRT7 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 ANXA10 KRT6B;KRT6C;KRT6A SCEL LEMD1 KRT17 MYO1A IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260211%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity CCL13;CCL2 IL1R1 SELENBP1 MYD88 HBEGF PLA2G7 F2R NFKB1 TLR2 IL18 TLR1 IFNG ICAM1 TIMP1 IL1B S100A9 TIMP2 NLRP3 F2 MMP9 PIK3CA FCER1A CCR3 IRAK1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260211%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome PPP4R3B CDIPT IGFBP3 DOC2A PPP4R1 PPP4R2 PPP4R4 CCT3 CCT2 PARP4 KIF22 TLCD3B ASPHD1 TCP1 KCTD13 UNC13B TMEM219 ZG16 INO80E UNC13A MVP MAZ TAOK2 CCDC6 GDPD3 SEZ6L2 CASP8 CORO1A HIRA HIRIP3 PPP4C CCT6B CCT8 CCT5 CCT4 IGBP1 ESR1 C16orf92 C16orf54 CCT6A YPEL3 MAP2K3 PAXIP1 KMT2C TBX6 NFKB1 PAGR1 PPP2R5D PTEN NR3C1 SIAH1 REL MSN EZR SPN TRAF2 PPP2R1A ALDOA MAPK3 QPRT CCT7 TRAF6 MAP2K6 KMT2D PPP2CB;PPP2CA PCNA BPTF TP53 PPARG HDAC3 PRRT2 PPP4R3A CREATINE PATHWAY%WIKIPATHWAYS_20260211%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 GATM GAMT OAT CKB NRF2 ARE REGULATION%WIKIPATHWAYS_20260211%WP4357%HOMO SAPIENS NRF2 ARE regulation GCLC CUL3 CEBPB EPHB2 GCLM PGAM5 PRKCA NFE2L2 GSK3B NQO1 MAPK8 YES1 RBX1 MAF GSTA3;GSTA5;GSTA1;GSTA2 SRC SLC7A11 HMOX1 KEAP1 AIMP2 PIK3CA INSR FYN CANCER PATHWAYS%WIKIPATHWAYS_20260211%WP5434%HOMO SAPIENS Cancer pathways TGFB2 TGFB1 TGFB3 STAT3 FN1 NFKB2 PLD1 MAPK10 MAPK9 VHL MAPK8 SMAD2;SMAD3 XIAP MITF CTBP2 CASP8 CTBP1 MMP2 TFG MMP3 EML4 NKX3-1 CCNE1 PLEKHG5 ARHGEF11 CUL1 APPL1 RASGRP2 RASGRP4 PDGFA TGFBR1-1 IGF1R RASSF1 AKT2 CDKN1A MYC AKT3 MAPK1 AKT1 MAPK3 FLT3 BRAF RUNX1T1 EPAS1 ZBTB16 LPAR2 FOXO1-1 LPAR3 IGF1 LPAR4 RARA PGF GNG10 LPAR5 CDK4 LPAR6 CDK2 ITGB1 KRAS JAK2 KIT VEGFB VEGFC VEGFD MGST3 KITLG MGST2 CSF3R EPO PRKCG ERBB2 IFNAR2 GSTM3 COL4A2 COL4A1 PRKCB PTK2 COL4A4 NFKBIA COL4A6 IFNAR1 PRKCA SKP2 CSF1R GNAS-1 ADCY9 HSP90B1 NCOA1 ITGA2B LAMC1 LPAR1 IL7R ITGA2 HSP90AB1 LAMC3 PLCG2 FLT4 PLCG1 LAMC2 JUN GSTP1 NFKB1 ITGAV GNG13 HSP90AA1 IL6 LAMA5 SP1 ITGA3 GNB2 GNAQ GNB1 GNAI3 GNB4 GSTA4 GNB3 GNB5 ITGA6 GNAI2 LAMA2 LAMA1 LAMA4 LAMA3 FLT3LG GNGT1 LAMB3 PRKACA-1 RASSF5 LAMB2 LAMB1 EPOR GSTO1 DCC FOS MSH3 MLH1 SLC2A1 PLCB3 ALK POLK CAMK2B CAMK2D BIRC2 BIRC3 CAMK2A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 TXNRD3 ADCY6 ADCY5 PRKACB-1 GNG2 GNG5 GNG4 GNG8 RPS6KA5 CAMK2G CASP7 AGT AGTR1 IL6ST NOTCH2 NOTCH3 NOTCH1 NOTCH4 STAT2 PIK3R3 HIF1A STAT5A STAT5B BDKRB1 LEF1 TCF7 HES1 HES5 TCF7L2 TCF7L1 KNG1 CALML6 ARAF CALML3 BMP2 FZD10 KEAP1 CALML4 FRAT2 CTNNA1 CTNNA3 CTNNA2 RAC3 E2F2 IKBKG RUNX1 SKP1 PTGS2-2 PIK3R2 PIK3R1 RBX1 FADD CKS1B TRAF1 F2RL3 TRAF4 FZD1 COL4A3 WNT10B TRAF5 WNT10A BCR FZD3 RARB COL4A5 FZD2 TRAF3 BIRC7 FZD5 FZD7 RXRB FZD6 RXRG ZBTB17 FZD9 LAMB4 FZD8 HHIP IKBKB IL13RA1 JUP HRAS APC2 PLCB4 TERT PLCB1 PLCB2 GSTM4 RELA CYCS-1 CXCR4 NRAS MAP2K2;MAP2K1 IFNGR2 BID PDGFRB WNT7B PDGFRA WNT7A HGF FAS CTNNB1 SOS2 MET PDGFB TGFA CDKN2A BCL2L11 WNT5B WNT5A EGF RPS6KB2 FGFR2 RAF1 BIRC5 CCDC42 WNT6 DVL1 TPM3 DVL2 DVL3 PPARD ESR2 WNT1 WNT2 WNT3 WNT4 WNT3A IL2RG GSK3B STAT4 WNT2B PIK3CD STAT6 IL12RB1 PIK3CB IL12RB2 CASP9 IL4R IFNGR1 CXCL12 CASP3 CHUK IL13 APAF1 AXIN1 TRAF2 IL2 IL4 EDN1 IL5 AXIN2 CXCL8 WNT16 IL5RA PIK3CA CRKL IL3RA CSF2RB LRP5 IL3 LRP6 MGST1 WNT11 NOS2 BAD NQO1 MTOR TXNRD2 APC GSTT2B;GSTT2 CDK6 E2F3 TP53 PPARG PAX8 CBL PIM1 PIM2 GRB2 SOS1 FGFR3 CCND2 FGFR4 ELK1 BMP4 SHH GSTM1;GSTM2-1 GNA12 GSTA3;GSTA1 GSTA3;GSTA5;GSTA1;GSTA2 CSF2RA IL12B IL12A IL6R IFNG IL23A RHOA TRAF6 CRK ROCK1 ROCK2 BAX FGF1 PTCH1 JAG2 JAG1 FZD4 GNA13 SMO FGFR1 GLI3 GLI2 HEY1 HEY2 WNT9B WNT9A WNT8A WNT8B IL7 BDKRB2 DLL1 DLL3 DLL4 PTGER4 CCDC6 PTGER2 SMAD4 CDH1 GLI1 PTCH2 KIF7 RXRA FASLG CDKN1B BBC3 CCND3 BCL2 NFE2L2 DDB2 CCNE2 HDAC1 RET PMAIP1 GADD45B GADD45G PTGER1 PTGER3 GNAI1 NCOA4 MST1 HEYL DAPK2 DAPK3 HMOX1 TXNRD1 KLK3;KLK2 EDNRB ARNT2 SPI1 CREBBP ETS1 HDAC2 EP300 CEBPA IGF2 MECOM ARNT ARHGEF12 DAPK1-1 GNA11 RPS6KB1 NTRK1 RB1 CCND1 RASGRP1 EDNRA RALA-1 MSH6 F2R AR MSH2 MAX MDM2-2 RASGRP3 TPR ABL1 GADD45A GSTO2 ESR1 CDKN2B PTEN BRCA2 RAC1 JAK1 MMP1 NCOA3 TGFBR2 EGFR E2F1 BAK1 STAT1 PML VEGFA RAD51 CCNA2-1 CCNA1 JAK3 PLD2 BCL2L1 RALGDS EGLN1 IL2RA EGLN3 IL2RB EGLN2 IL15 FH RALBP1-1 CUL2 ELOB ELOC-1 ARHGEF1 RALB F2 TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260211%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis CEBPA CEBPB CEBPD NRIP1 SLC2A4 MAPK8 IL6 LEP LPIN1 CREB1 IRS1 RXRA PPARG PPARGC1A IRS2 TNF NR3C1 INSR PCK2 ADIPOQ FOXO1-1 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260211%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 CCL13;CCL2 MAPK14 CD14 TLR4 REL RELB MAPK12 NFKB2 MAPK13 CREB3L2 NFKB1 MAPK11 IL6 IL10 CREB3 ATF4 CREB1 CREB3L3 IL1B CREB3L4 CREB3L1 CREB5 RELA DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260211%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR RFWD3-2 PALB2 PPM1D RBBP8 POLN MCM2 MSH2 WRN MDM2-2 BARD1 RNF8 USP1 PLK1 CDC45 ATM DCLRE1A UBE2D3-1 HERC2 SP1 ATR RECQL EEF1E1 XRCC5 SMARCC2 RECQL5 CLSPN TDP1 BRCA1 BRCA2 FANCD2 CEP164 SMARCAL1 NBN XPA SEM1 SMC1A IKBKG CDC25C E2F1 FANCI PML ATRIP MLH1 FOXM1 RPA2 RAD50 BCL6 MDC1 RAD52 RAD51 CDK1 RAD17 FEN1 TRIM28 RAD1 EXO1 RAD9A UPF1 BRCC3 RPA1 HUS1 TOPBP1 MCPH1 POLB TP53BP1 CLK2 CDK2 PCNA UIMC1 RMI1 TOP3A MRE11 ABRAXAS1 TP53 PARP1 BRIP1 CHEK2 PRKDC CHEK1 FANCA MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260211%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders ACSL1 ACSL4 HADHA HADHB-1 ACADVL ACSL3 SCP2 ECI1 ACSF2 CPT1A ACADL SLC25A20 ACADS EHHADH-1 PECR SLC22A5 CPT2 ACADM HADH STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis HSD3B1;HSD3B2 CYP11A1 CYP17A1 SRD5A2 CYP21A2 SRD5A1 AKR1D1 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260211%WP5087%HOMO SAPIENS Pleural mesothelioma TGFB1 FN1 ACTA2 MAPK10 MAPK9 CDH7 MAPK8 CCN2 CTBP2 CTBP1 CASP1 MMP2 MMP3 CCNE1 CDH18 MMP14 CUL1 HCFC1 PHC1 PRSS23 DSC3 BAG2 MDK CTHRC1 RASSF2 RASSF3 RASSF4 RASSF6 MDM4 IL34 MAD2L1 RNF2 NTF3 FLT1 PDGFA FOXM1 IGF1R INS;INS-IGF2 RASSF1 AKT2 CDKN1A MYC AKT3 MAPK1 AKT1 MAPK3 FLT3 INSR YAP1-1 EPHA2 WIF1 FOXO1-1 IGF1 PGF IDO1 CDK4 CDK2 ITGB1 PIK3CG ATF2 KIT CD47 VEGFB ACTG1 VEGFC VEGFD SRC KITLG CSF3 EIF4EBP1 COL4A2 COL4A1 PTK2 COL4A4 COL4A6 SHC1-1 CSF1R EFNA5 MAD1L1 EFNA4 FGF20 ITGB3 FGF22 FGF21 FGF17 EFNA1 ATF3 EFNA3 FGF14 LAMC1 EFNA2 ITPR3 FGF19 ITGA2 FGF13 FGF12 SLC7A5 FGF11 LAMC3 ITGB4 FLT4 LAMC2 HBEGF JUN NFKB1 ITGAV IL6 LAMA5 SP1 ITGA3 ACTB-1 NGF ITGA6 LAMA2 LAMA1 ACTC1;ACTG2 LAMA4 YWHAB LAMA3 NTF4 ANGPT4 FLT3LG ANGPT2 LAMB3 ANGPT1 RASSF5 LAMB2 LAMB1 GABPA SELE TEK SLC2A1 ACTA1 CREB1 IL1B BTC ROR2 RING1 RPS6KA5 MAP3K6 PDGFD MAP4K1 MAP4K2 MINK1 MAP4K3 MAP4K4 MAP3K2 HIF1A SOST PAK2 PLAU LEF1 TCF7 NF2 ADAMTS1 TCF7L2 TCF7L1 SAV1 FZD10 MOB1A;MOB1B FRAT2 CSNK2A2 CTNNA1 CTNNA3 DKK1 CTNNA2 ATG13 DKK2 DKK4 SFRP4 DDIT3 CSNK2B ULK2 ULK1 BTRC CSF2 FZD1 CD274 COL4A3 WNT10B WNT10A FZD3 COL4A5 FZD2 FZD5 FZD7 FZD6 FZD9 SPARC AMOT FZD8 ITGB2 RPS6KA1 LGALS9C;LGALS9;LGALS9B HRAS EED PLCB4 TERT CSNK2A1;CSNK2A3 CYCS-1 SUZ12 MAP2K2;MAP2K1 KDR CSNK1A1 PDGFRB WNT7B PDGFRA WNT7A HGF CTNNB1 CSF1 CDH9 CDH8 CDH4 MET CDH3 AJUBA CDH20 PDGFB CDH22 TGFA CDH24 CDKN2A WWTR1 LIN28B PDGFC MAP3K5 CDH10 WNT5B CDH11 WNT5A CDH12 EGF CDH13 CDH15 RPS6KB2 FGFR2 CDH17 VGLL4 CD44 RAF1 CDH19 AGER WNT6 DVL1 YY1 DVL2 DVL3 MAP2K7 WNT1 WNT2 WNT3 WNT4 WNT3A TPTEP2-CSNK1E;CSNK1E MCU EIF4G1 GSK3B WNT2B PIK3CD MCL1 PIK3CB IL10 RB1CC1 CXCL12 AXIN1 TRAF2 WNT16 PIK3CA BECN1 LRP5 LRP6 UHRF1 WNT11 MTOR APC TP53 CIT TEAD4 FGF2 STK3 LATS1 LATS2 TEAD1 TEAD2 TEAD3 GRB2 SOS1 FGFR3 CCND2 TELO2 FGFR4 MEF2D MAP3K1 ELK1 TTI1 SFRP1 CCL13;CCL2 FGF10 RPS6KA3 MAP3K9 MAP3K4 BDNF MAP2K3 MAP2K4 CCL5 MAP3K10 MAP3K11 CCL4L2;CCL4L1;CCL4 BMI1 PDK1 MAPKAPK2 MAP2K5 NGFR RYK-1 ROR1 MAPK7 BAX MKNK1 MAP3K3 NTRK2 SERPINF1 FGF1 FGF3 FGF4 FGF5 FGF6 PIGF FGF7 FGF8 FGF9 KREMEN1 SENP2 SFRP5 CXXC4 PORCN FGF18 NOTUM FGFR1 HMGB1-1 CHD8 AREG NLRP3 CXCL2;CXCL3;CXCL1-1 MMP9 CXCL10 CDH6 CDH2 CDH1 CDH16 RBBP4 SFRP2 BBC3 CCND3 MKNK2 BCL2 WWC1 SOX17 CER1 STK38L TNIK CXCL5;CXCL6 SETD5 NDRG1 MST1 SETDB1 SLC3A2 LIMD1 OGT-1 PPARGC1A TNNT1 KIF23 KMT2C WDR5 KDM6A ASXL1 BAP1 BUB1B-PAK6;PAK6 PAK3 PAK5 PAK4 EZH2 IGF2 FABP4 PRKAA2 RPTOR DEPTOR MLST8 EIF4B ITGA1 CDH5 RPS6 PRKAA1 RPS6KB1 RHEB NTRK1 AKT1S1 CCND1 TSC2 TSC1 FGF23 MAX MDM2-2 HMGN1 BARD1 FOSL1 CDK7 ATM PTEN BRCA1 JAK1 PODXL EGFR RASSF7 PRKAG1 PAK1 PRKAG2 E2F1 BAK1 STAT1 PRKAG3 VEGFA PRKAB2 PRKAB1 MAP2K6 MAPK14 SETD2 ITGA4 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP75%HOMO SAPIENS Toll like receptor signaling CD14 NFKBIA IFNAR1 NFKBIB MAP2K2;MAP2K1 MAPK10 MAPK9 MAPK8 CXCL9 TNF CASP8 CXCL10 IRF7 CCL3L1;CCL3L3;CCL3;CCL18 IRF5 MAP2K3 MAP2K4 JUN MAPK12 MAPK13 TLR2 CCL5 NFKB1 TAB1 MAPK11 IL6 TLR1 TLR6 TICAM2 RAC1 TIRAP CCL4L2;CCL4L1;CCL4 RIPK1 TICAM1 IKBKE IRAK1 MAP2K7 CD86 CD40 IRAK4 CD80 SPP1 TOLLIP TAB3 TAB2 TBK1 MYD88 IKBKG IL12B LY96 IL12A STAT1 CXCL11 IRF3 FOS TLR8 TLR3 CHUK FADD AKT2 IL1B IFNB1-4 AKT3 TLR5 CXCL8 TLR9 MAPK1 AKT1 TRAF3 TLR7 MAPK3 TRAF6 MAP2K6 MAPK14 TLR4 IKBKB LBP MAP3K8 MAP3K7 IFNAR2 RELA DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism EPHX2 PTGS2-2 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260211%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway PTPN6 PLCG1 CD34 PRKCA HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CSF2 LCP2 IFNG HRAS PRKCQ GRB2 VAV1 LAT TYROBP ITPR1 TNF RAC1 SYK FYN PTPN2 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260211%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma RNF2 SUZ12 KDM2B PCGF1 H3-3A DUSP6 H2AZ2;H2AZ1 H2AJ BCL6 EED MACROH2A1 MAPK1 BCOR H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MAPK3 MACROH2A2 H2AB2;H2AB3;H2AB1 EZH2 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260211%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders COQ2 PDSS2 ETFDH ETFA COQ9 APTX COQ7 SLC52A1;SLC52A2 COQ6 PDSS1 COQ8A RFK FLAD1 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260211%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy SUOX ETHE1 TST NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260211%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS2-2 PTGS1 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260211%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling PTK2 PRKCD PRKCA SHC1-1 LAMB3 GAB1 LAMB2 PIK3R2 LAMB1 PIK3R1 GRB2 SOS1 LAMC1 IRS1 IRS2 MAPK1 AKT1 MAPK3 RHOA MAPK14 ITGB4 LAMC2 LAMA5 MTOR HRAS SRC RAC1 ITGA6 EIF4EBP1 LAMA2 LAMA1 LAMA3 PTPN11 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260211%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection CD14 TUBB4B PRKCA LY96 YWHAQ TUBB4A;TUBB;TUBB8B;TUBB8 ARPC5 EZR ARPC1A TUBA8 ARPC4 KRT18 NCL-1 ARPC2 ARHGEF2 YWHAZ ARPC3 CTNNB1 TUBA1C ABL1 TUBA1A TLR5 WASL RHOA TUBB1 ROCK1 ROCK2 CLDN1 TUBB2B;TUBB2A TLR4 ITGB1 CDH1 TUBA4A OCLN-1 TUBB3;TUBB6 CTTN TUBAL3 CDC42 ARPC5L NCK2 ACTB-1 ACTG1 NCK1 WAS TUBA3E;TUBA3C-1 HCLS1 FYN ARPC1B MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis MOCS2 GPHN MTARC2 MOCS1 AOX1 SUOX XDH NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260211%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC22A2 SLC31A1 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260211%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds LRP1 FZD8 SFRP4 GSK3B LEF1 CSNK1A1 APC TCF4 CTNNB1 AXIN1 FZD1 MBOAT1 DKK3 TNKS DVL2 FZD7 WNT1 CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260211%WP536%HOMO SAPIENS Calcium regulation in cardiac cells FXYD2;FXYD6-FXYD2 GNAZ GJB1 ATP1B2 CACNA1B KCNJ5 CACNA1A CACNB1 CAMK4 GJC2 GJB6 CACNA1E CASQ1 GNAO1 FKBP1A GJA9 STIM2 GJC1 GJB4 GJB3 GJB5 ANXA6 GJD2 CASQ2 ATP1A4 KCNJ3 KCNB1 ATP1B3-1 GNA11 SLC8A3 GJA3 GJA5 GJA8 CHRM2 CHRM3 SLC8A1 RGS4 ADRA1D RGS5 RGS2 GJA1 RGS3 RGS1 RGS9 RGS6 RGS7 PRKCG PRKCH PRKCB PRKCE PRKCD PRKCA GNAS-1 CACNB3 ADCY9 PRKAR1B CALR-1 PRKAR1A PRKCQ PRKD1 ITPR1 ITPR2 ITPR3 PRKCZ ADRB2 GRK5 PRKAR2B GRK4 PRKAR2A GRK6 SFN GNG13 PKIB CACNA1D CACNA1C GNB2 GNAQ CHRM1 PKIA GNB1 GNB4 GNAI3 GNB3 GNB5 PKIG CALM1 GNAI2 CALM2 RYR1 CACNA1S YWHAE ATP2B3 RYR2 ATP2B2 ATP2B1 GJB2 YWHAB ATP2A3 ATP2A2 ARRB1 CHRM4 CHRM5 ARRB2 ORAI1 ADRB1 RYR3 GNGT1 PRKACA-1 YWHAQ ADRA1B YWHAG ADRA1A YWHAH YWHAZ PLCB3 RGS18 CAMK2B RGS17 CAMK2D RGS19 GNAI1 GJA4 RGS14 RGS16 CAMK2A ADCY4 ADCY3 ATP1B1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 GNG2 GNG5 GNG4 RGS20 CAMK1 GNG8 CAMK2G CALM3;CALM1 RGS10 ADRB3 RGS11 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260211%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling PRKCB IFNAR1 DUSP2 STAT3 IL10RA F2R MAPK10 IL10RB IFNGR2 MAPK9 IL11RA MAPK8 IFNLR1 PDGFRB PDGFRA AGTR1 MAPK6 IL6ST MAPK4 IL7R AGTR2 MAPKAP1 MAPK12 TYK2 MAPK13 MAPK11 CTF1 PTPRC CNTFR CREBBP GHR JAK1 LIFR CSF2RA IL27RA IL2RG EGFR STMN1 IL6R IL21R IL12RB2 RPTOR DEPTOR IFNGR1 MLST8 F2RL3 TRIM28 MAPK1 IL5RA MAPK3 IL3RA MAPK14 IL9R CSF2RB MAPK7 PTPRT SETD7 MPL JAK3 AKT1S1 MAPK15 IL22RA1 OSMR PTPRD IL2RA JAK2 IL2RB PIAS3 MTOR IL20RA IL20RB SRC CSF3R SOCS3 RICTOR IFNAR2 F2RL2 DOPAMINE METABOLISM%WIKIPATHWAYS_20260211%WP2436%HOMO SAPIENS Dopamine metabolism SOD1 PPP2CB;PPP2CA PRKACA-1 MAOB PRKACB-1 NQO1 COMT DDC TH TYR MAOA HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma TGFB1 CASP7 STAT3 MAPK8 SMAD2;SMAD3 RRM2-1 GRB2 SOS1 MYOF HNF1A HIF1A CXCR1 SMAD4 CD44 JUN NFKB1 LEF1 CTTN IL6 BIRC5 UCHL1 BRCA1 FASLG RAC1 JAK1 FRZB MMP1 PODXL E2F2 PTGS2-2 IL6R CASP9 VEGFA TGFBR1-1 CASP3 CDKN1A MYC CXCL8 AKT1 MAPK3 BIRC3 MAPK14 BCL2L1 NOS2 VAV2 TP53 CCND1 COL4A2 PTPN11 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260211%WP5355%HOMO SAPIENS Metabolic epileptic disorders PHGDH CTH SFXN1 GLDC SQOR AMT SUOX ETHE1 GOT1-1 ECHS1 CDO1 ACAT1 SHMT1 HADH PFKL ARG1 PFKM ENO2 GPI ENO3 MPC2 GLS2 PGAM2 FBP2 DLAT LDHAL6B PKLR ALDH7A1 SLC25A15 DLD ALDOB GOT2-1 ASL FBP1 GCDH G6PC1 PCK1 PGK1 GAMT ALDOC ENO1 HK1 PDHA1 MDH1 MDH2 GPHN GCK ASS1 GLUD1;GLUD2 ACO1 SLC2A4 PC CPS1 GAPDH-1 SLC2A5 SPCS1 MOCS2 SLC2A1 SLC2A2 BTD SLC25A1 MOCS1 HLCS OTC ALDOA AADAT GATM HK3 CBS;CBSL SLC25A5 HK2 PKM MOCS3 XDH AASS SLC7A2 SLC1A5 PSPH GPT DHTKD1 LDHB LDHA;LDHC LDHA MPC1 TPI1 PGAM1 PSAT1 SHMT2 PFKP MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260211%WP2003%HOMO SAPIENS miR targeted genes in leukocytes NELFCD ANPEP ATP6V0E2;ATP6V0E1 CHORDC1 SNAP23 CAP1 IFRD1 PISD KCNN4 TYMS ATP6V0A1 SNX6 TUBA1A TRAM1 TMED3 CTSC RHOG PRPF40A GAK CDCP1 FRG1 POM121;POM121C BRPF3-1 DDX5 IDH1 PTPA CEBPB SHOC2 ARHGDIA AP3D1 ACAA2 C1orf56 ARID4B VPS39 GOLGA7-1 WDFY1 MATR3 TMED10 SERPINE2 SLC1A4 PKM DCAF7 TBCA IGF2R CDK5RAP1 CDK5RAP3 TNFAIP2 ADAR PRSS21 LMNB2 TMEM109 SCYL1 MTHFD2 PPIB RFT1 MRPL20 PNP-1 RDH10 GNA13 CAPG PHC2 PDLIM5 HNRNPM CDIPT TNFSF9 SFXN1 POLE4 FMNL2 MRC2 TMEM43 CSRP1 SH3BGRL3 SPTLC1 ANXA2 CTNNB1 SLC7A6 ZEB1 PTRH1 USP1 SRSF10 ARCN1 WDR11 PPIF CA12 LAMTOR3 PLXND1 LPL TUSC2 ARF4-1 RTN4 FADS1 THBS1 G6PD GNAI2 TPM3 RAB34 ANAPC1 ATP2A2 RAB5C BCL2 CORO1C RAB6A YWHAQ SAC3D1 MCL1 MPDU1 CD164 GYS1 BCL6 SLC25A1 ADPGK SLC7A11 ACP2 ADIPOR2 MAPK14 UNC93B1 TXN2 DNAJB1 POLR2C CDK6 MAP3K8 HMOX1 SEC24A TXNRD1 ATP6V1F APOPTOSIS%WIKIPATHWAYS_20260211%WP254%HOMO SAPIENS Apoptosis CYCS-1 NFKBIA HRK CASP7 NFKBIB CASP2 DFFB DFFA MAPK10 IRF2 BID TNFRSF25 IRF1 MDM2-2 XIAP FAS CRADD BCL2L2 TNF CASP8 MAP3K1 IRF7 BCL2L11 CDKN2A CASP1 IRF5 MAP2K4 JUN LTA NFKB1 BNIP3L BIRC5 IRF4 TRADD CASP10 FASLG CASP5;CASP4 DIABLO-1 CFLAR CASP6 HELLS NFKBIE RIPK1 TNFRSF21 BBC3 BCL2 IKBKG IGF2 TNFSF10 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PIK3R1 BAK1 MCL1 BOK CASP9 IRF3 PMAIP1 CASP3 IRF6 TP63 CHUK FADD IGF1R APAF1 TRAF1 TRAF2 MYC TP73 AKT1 TNFRSF1A TRAF3 BIRC2 IGF1 BIRC3 BAX PRF1 BCL2L1 IKBKB BAD GZMH;GZMB-1 SCAF11 TNFRSF1B TP53 RELA OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260211%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP4F22 CYP4X1 CYP11A1 CYP7B1 CYP2B6 CYP39A1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 CYP26A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP27C1 CYP19A1 CYP26B1 CYP2D6;LOC107987479;LOC107987478-1 CYP11B1;CYP11B2 CYP4V2 CYB5A CYB5R3 CYP7A1 CYP2J2-1 CYP17A1 POR CYP2F1 CYP4B1 CYB5R2 CYP1A1 CYB5R1 CYB5R4 CYP2E1 CYP27B1 CYP8B1 CYP2C18-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP24A1 CYP20A1 CYP1A2 CYP1B1 CYP2R1 CYP46A1 CYP51A1 CYP2U1 CYP27A1 CYP2W1 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260211%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma MAP2K2;MAP2K1 MAGI2 CNTN6 MAX NCOR1 FGF16 NOTCH1 FGFR4 CTBP1 BCOR DTX4 FBXW7 RAF1 KMT2C ATM MYBL1 KDM6A PTEN CREBBP BRCA1 KDM6B EP300 ARID5B CEBPA TLK1 NFIB SMC1A SMARCA2 ARID4B IL17RD MYC MYCN AKT1 PIK3CA ATRX BCORL1 SETD2 MYB UHRF1 SMARCE1 HRAS ERBIN JMJD1C TP53 CMTR2 MAML3 MAGI1 BRD1 SRCAP NSD1 INSRR ARID1A CHEK2 MORF4L1-2 FOXO3 FOXP2 PRKDC CHEK1 KAT6A MGA ERBB2 MYCBP-1 H2AC16;H2AC11 H1-4 KANSL1 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy PRKCB TGFB1 MYLK MAP2K2;MAP2K1 STAT3 MAPK8 AGT PDPK1 NRG1 IL6ST GATA4 MAPK4 CTNNB1 TNF PIK3R3 WNT5A EGF CDK7 MAP2K3 FGFR2 MAP2K4 RAF1 RCAN1 NFKB1 TAB1 CTF1 LIF MYLK3 EIF2B5 RAC1 DVL1 CALM1 IKBKE MAP2K7 MYEF2 WNT3A PLA2G2A-1 IKBKG GSK3B PIK3CD PIK3R2 PIK3R1 PIK3CB CHUK IGF1R MAP2K5 MAP3K14 PRKG1 FZD1 AKT2 EDN1 HDAC4 MAPK1 AKT1 HDAC5 FZD2 PIK3CA MAPK3 RHOA CAMK2D HDAC9 MAP2K6 HDAC7 ROCK1 ROCK2 IGF1 MAPK14 LRP5 MAPK7 NFATC4 CDK9 PIK3CG LRP6 IKBKB NPPB PPP3CA PPP3CB MTOR CISH FGF2 PLCB2 NPPA THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260211%WP4297%HOMO SAPIENS Thiamine metabolic pathways TPK1 OGDH SLC25A19 SLC19A3 TKT BCKDHA PDHA1 SLC19A2 BCKDK TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260211%WP619%HOMO SAPIENS Type II interferon signaling IRF9 GBP2;GBP3;GBP1 PRKCD PSMB9 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IFNGR2 IRF2 STAT1 IFNG IRF1 IFNGR1 IFIT2 CXCL9 IL1B IFNB1-4 STAT2 REG1B;REG1A CXCL10 EIF2AK2 CYBB CIITA ISG15 SPI1 NOS2 JAK2 IRF4 ICAM1 IRF8 SOCS3 SOCS1 JAK1 TAP1 OAS1 PTPN11 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260211%WP5300%HOMO SAPIENS TROP2 regulatory signaling PTK2 BCL2 PRKCD TACSTD2 PRKCA EGFR FN1 RACK1 IGF2 PIK3R1 STAT1 IGF1R CTNNB1 NOTCH1 CDKN2A IGF1 CLDN1 BAX CDK4 ITGB1 CDK2 IGF2R CDH1 JUN PECAM1 CCNE1 CLDN7 NFKB1 PSEN2 JAK2 VIM RB1 MMP13 ACVRL1 PTEN SRC CCND1 ABCC1 MDK CHEK1 RAC1 ITGA5 TLN1 CDKN1B PAK4 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260211%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification SOX6 GJA5 PLAT DLL1 DLL3 DLL4 VEGFA CALU FGFR3 NOTCH1 LPAR1 ITGA1 SAT1 JAG2 ALPL JAG1 MGP MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway ACAT2 GGPS1 IDI1 FDPS ACAT1 MVK HMGCR IDI2 HMGCS1-1 HMGCL PMVK MVD FDFT1 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation MAP2K2;MAP2K1 NPR2 STAT1 FGFR3 CDKN1A MAPK1 MAPK3 BMP4 MAPK14 CNP THRA PPP2CB;PPP2CA MAPK12 RAF1 MAPK13 PTHLH SNAI1 MAPK11 IHH RBL1 FGF9 SOX9 BMP2 PTH1R ATG5 FGF18 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP558%HOMO SAPIENS Complement and coagulation cascades CLTC F2R PROS1 C3AR1 CR2 PLAUR SERPINA1 CLU SERPING1 SERPINA5 MASP2 THBD MASP1 C8G CFB PLAU BDKRB1 CFD SERPINF2 F3 VWF F5 F8 F9 C1S CPB2 C1R C5AR1 SERPINC1 CFI KNG1 LMAN1 SERPIND1 PROC F13B C6 C1QB C7 C9 TFPI C2 CD55 F10 F12 CR1L;CR1 LOC110384692;C4A;C4B_2;C4B C3-1 CFH-3 KLKB1 C1QC SERPINE1 PLAT FGB F2 F7 PLG T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260211%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection NFKBIA PTPN6 MAP2K2;MAP2K1 CHP1 AHSA1 CD4 MAPK9 PRKCQ GRB2 SOS1 RRAS ITK TNF CTLA4 PLCG1 GRAP2 RAF1 JUN NFKB1 LCP2 DLG1 CARD11 BCL10 MALT1 PTPRC LAT CALM1 PDK1 MAP2K7 IKBKG GSK3B PAK1 CSF2 CD40LG IFNG IL10 FOS CD28 CD3D CHUK MAP3K14 IL2 IL4 IL5 AKT1 PIK3CA MAPK3 PDCD1 ICOS NFATC2 CDK4 LCK IKBKB CD8A NCK1 ZAP70 MAP3K8 MAP3K7 DAG1 CBL FYN DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260211%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte PRDM16 CEBPA CEBPB CEBPG HSPB7 HOXC9 PLAC8 HOXC8 MPZL2 ZNF423 EBF3;EBF1 CIDEA SMAD1 BMP7 SMAD5 BMP4 ZIC1 ADIPOQ LEP PPARGC1B PPARGC1A PPARG BMP2 SLC7A10 SMAD9 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260211%WP4255%HOMO SAPIENS Non small cell lung cancer PRKCB CYCS-1 NRAS PRKCA MAP2K2;MAP2K1 STAT3 BID PDPK1 GRB2 HGF SOS1 SOS2 MET CASP8 KIF5C GADD45A KIF5B KIF5A TGFA CDKN2A STAT5A CRABP2 STAT5B EGF PLCG2 CRABP1 PLCG1 EML4 RAF1 STK4 ARAF RXRA E2F2 EGFR DDB2 RASSF5 E2F1 PIK3CD BAK1 PIK3CB CASP9 RET CASP3 GADD45B GADD45G RASSF1 ALK CDKN1A AKT2 AKT3 RARB POLK MAPK1 AKT1 PIK3CA FHIT MAPK3 RXRB RXRG BRAF BAX CDK4 JAK3 KRAS BAD RB1 HRAS CDK6 E2F3 TP53 CCND1 FOXO3 PRKCG ERBB2 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260211%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer RPH3A MADD RPH3AL SYTL1 MLPH GCC2 MYRIP SYTL5 RAB27A SYTL4 UNC13D SYTL3 SYTL2 RAB27B TBC1D10A EXPH5 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260211%WP45%HOMO SAPIENS G1 to S cell cycle control MYT1 CDC25A MCM2 CDKN1C MDM2-2 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CCND2 MCM7 MCM3 GADD45A POLA2 MCM5 MCM6 CDKN2A CDC45 CDK7 MCM4 PRIM2 CCNE1 ATM CDKN2D TFDP1 CDKN2B CDKN2C CCNG2 PRIM1 CDKN1B CCND3 E2F2 CCNH CCNE2 E2F1 CCNB1 MNAT1 CREB3 RPA2 WEE1 CREB1 CDKN1A CREB3L3 CDK1 MYC CREB3L4 CREB3L1 RPA3 RPA1 CCNA1 ATF6B POLE CDK4 CDK2 PCNA POLE2 RB1 CDK6 E2F3 TP53 CCND1 TFDP2 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260211%WP5506%HOMO SAPIENS Disorders of NAD metabolism CD38 NADSYN1 BST1 NAXE NAXD SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260211%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response HAVCR2 IFNAR1 TGFB1 DHX58 TRIM25 SMAD2;SMAD3 ACE2 CD160 IFIT2 CXCL9 TP53I3 CXCL17 TNF CASP8 CXCL2;CXCL3;CXCL1-1 CXCL13 STAT2 CXCL10 IRF7 AP1G1 PF4;PF4V1-1 CCL3L1;CCL3L3;CCL3;CCL18 NUP98 RAE1 CCL13;CCL2 PPBP CXCR2 CCL5 NFKB1 IL6 TRADD HDAC2 JAK1 CCL4L2;CCL4L1;CCL4 RIPK1 IFITM3;IFITM2;IFITM1 TANK EP300 BSG LAG3 TBK1 CSF2 DDX58 IL6R STAT1 CXCL11 TFAP2A IL10 IRF3 CXCL12 FADD MAVS TRAF2 TRAF5 IFNB1-4 CXCL8 TRAF3 TLR7 CXCL5;CXCL6 TRAF6 LARP1-1 MX1-1 IFNAR2 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer SHISA5 CYS1 SESN3 EI24-1 BAX ZMAT3 PERP DDB2 ATM TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SERPINE1 BID MDM2-2 CASP9 PMAIP1 CASP3 TP53 APAF1 PTEN CHEK2 CASP8 SIAH1 BBC3 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260211%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials LRP5 CTNNB1 CREBBP LRP6 PORCN TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260211%WP465%HOMO SAPIENS Tryptophan metabolism ASMT AANAT IL4I1 AOX1 KYAT3 KYAT1 ECHS1 STAT1 ACAT1 TDO2 AADAT HADH HAAO KMO ACMSD KYNU INMT AFMID IDO2 IDO1 CAT AOC1 ALDH8A1 DLD GOT2-1 TPH2 DDC GCDH TPH1 CYP1A1 MAOA AHR ALDH2 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260211%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress SOD2 MAPK8 MDM2-2 SIRT1 TNF MAP3K5 PINK1 MAP2K3 MAP2K4 IPCEF1 CCNE1 PIP-1 NFKB1 GSX1 IL6 ATR PTEN KEAP1 BCL2 NFE2L2 IKBKG PTGS2-2 FOS NRF1 CREB1 CDKN1A CXCL8 AKT1 PIK3CA FOXO1-1 MAPK14 CUL3 CAT RHEB CDK2 NOX1 ATF2 BCL2L1 NOS2 IKBKB NQO1 MTOR ICAM1 RPS6KA5 TP53 IL1A HMOX1 CHEK1 TSC1 UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260211%WP5158%HOMO SAPIENS Urotensin II mediated signaling TGFB1 STAT3 FN1 ACTA2 COL1A1 MAPK9 MAPK8 SMAD2;SMAD3 AGTR1 CTNNB1 TNF MMP9 FSCN1 CYBB MMP2 CCNE1 NFKB1 TRPC4 IL6 GSK3A PTEN CREBBP EP300 HSPA2 DDIT3 BCL2 EGFR PRKACA-1 GSK3B CASP9 IRF3 NCF1 NCF4 CASP3 ESPL1 CHUK IL1B CDK1 MAPK1 AKT1 HDAC5 CYBA MAPK3 AIFM2 RHOA NCF2 ALOX5 MAPK14 CAMK2A BAX VCAM1 CDK2 NOX4 PCNA IKBKB JAK2 UTS2R COL2A1 NPPB ICAM1 COL3A1 HMOX1 NPPA RELA ABCA1 PTPN11 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes VDAC1 FABP3 FABP4 SLC27A2 APOE LIPA SLC27A4 APOC2 OSBPL5 FABP2 LRP1 ACSL1 ACSL6 SOAT1 STARD3 ACSL5 APOC1 ACSL3 SCARB1 SORT1 SLC27A3 SOAT2 PCSK9 FABP1 APOA4 NPC2 MYLIP SLC27A1 APOB LDLRAP1 LDLR STAR ABCA1 NEPHROGENESIS%WIKIPATHWAYS_20260211%WP5052%HOMO SAPIENS Nephrogenesis WNT4 FOXD1 WNT3A OSR1 ALDH1A2 WNT9B PAX2 GREB1L FGF20 MEIS1 NOTCH2 FGF8 RSPO1 BMP7 JAG1 TCF21 SIX2 RSPO3 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260211%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction TNFRSF4 TGFB2 TGFB1 TGFB3 TNFRSF9 TNFRSF25 TSLP IL9 INHBB BMP4 ANP32B CXCR6 CCR2 CCL13;CCL2 CCL11 CX3CL1 CCL5 CCL23;CCL15 CCL14 TPO GHR CCL4L2;CCL4L1;CCL4 CCL8 IL34 CCL1 TNFRSF12A IL1R1 CD40 CSF2RA IL25 ACVR2A TNFSF13B IL6R CD40LG CD27 IFNG IL23A TGFBR1-1 IL17F IL17D IL17C NGFR IL17B IFNB1-4 IL17A IL1R2 PRL MPL IL22RA1 IL1RL2 PRLR CSF3 CSF3R EPO IFNAR2 BMPR1B IFNAR1 CSF1R IL7 TNFSF15 CCR7 CXCL9 CXCR5 IL1RN CXCL2;CXCL3;CXCL1-1 CXCL17 CXCL13 CXCL14 CXCL10 IL36A IL7R IL36B PF4;PF4V1-1 CCL3L1;CCL3L3;CCL3;CCL18 IL36RN CNTF XCL1;XCL2 IL36G PPBP AMHR2 IL1F10 IL20 IL26 IL24 IL27 IL19 IFNK LIF IFNL2;IFNL3;IFNL1 IL6 CCL25 TNFSF14 IL33 GDF2 CCL24 CCL20 GDF1 IL31 GDF6 CCL22 TNFRSF19 GDF7 CCL21 NGF RELT IL37 CD70 CCL27 CLCF1 CCL26 TNFRSF8 IL13RA2 FASLG TNFRSF17 INHBC ACKR3-2 BMP5 IL1RAP INHBE TNFRSF18 ACVR1C LTBR INHBA GDF5 BMP15-1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A EPOR CXCL5;CXCL6 GDF9 INHA GDF3 ACVRL1 NODAL EDA EDA2R CCR6 IL11 TNFRSF14 IL11RA IL6ST AMH BMP7 MSTN CCR9 LTA CCR10 CCR1 TNFRSF11B XCR1 CCL19 CCL28 IL18R1 LTB CCR8 CCR4 TNFRSF11A GDF11 BMP10 CSF2 CXCL11 BMP8B TNFRSF13C IL17RC IL17RB IL17RA IL9R TNFSF11 IL13RA1 LEP IL18 TNFRSF1B IL1A CX3CR1 CXCR4 ACKR4 CCR5 GDF15 TNFSF9 BMP6 TNFSF4 IL10RA EDAR IL10RB IFNGR2 IFNLR1 FAS CSF1 TNF IL31RA CXCR1 CXCR2 ACVR1B IL1RL1 BMPR1A BMPR2 CNTFR BMP3 GDF10 TNFRSF21 ACVR1 LIFR TGFBR2 IL21 IL22 IL23R ACVR2B IL27RA NFIC IL2RG IL18RAP TNFSF10 IL21R IL12RB1 IL12RB2 IL10 IL4R IFNGR1 CXCL12 IL13 LEPR IL2 IL4 IL5 CXCL8 IL5RA TNFRSF1A CCR3 IL3RA CSF2RB IL3 TNFRSF13B IL2RA IL2RB IL20RA IL15 IL20RB NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260211%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons CHRNA5 CHRNA4 PPP1CA CHRNA6 KCNK3 ADCY2 DRD2 CDK5 DRD3 DRD4 PRKACA-1 GNG2 DDC TH SLC18A2 CHRNB2 GNB1 PPP1R1B CHRNA3 GNAI1 KCNK9 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome GLI3 PEX3 CD4 CD82 ARNTL LGALS3BP CHST6 SHH EXT2 CHST1 HBEGF LEF1 HLA-DMB ITGA3 CD63 HLA-DRA ITGA6 REST MAPK8IP1 CD151 ALKBH3 SPPL2C ACCS NRXN1;NRXN3;NRXN2 CD19 C11orf96 HLA-DMA C11orf94 LARGE2 CD53 SLC35C1 SLC25A17 B3GNT7 PRDM11-1 IGSF8 B4GALT4 PHF21A ALX4 TP53I11 SYT13 MS4A1 VANGL1 B4GAT1 TSPAN18 IZUMO1-1 CRY2 ITGB2 SDCBP ITGB1 ITGA4 CLOCK TIMP1 TP53 EXT1 NDST1 PEX16 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260211%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization CXCR4 CCR5 TGFB2 TGFB1 TGFB3 IL12B IL12A CSF2 CD4 IFNGR2 IL12RB1 CD40LG IL12RB2 IFNG IL4R CD28 IFNGR1 CCR7 IL2 IL4 IL5 CCR3 CCL3L1;CCL3L3;CCL3;CCL18 CCR2 CXCR3 CCR1 IL18R1 CCL4L2;CCL4L1;CCL4 CCR4 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260211%WP528%HOMO SAPIENS Acetylcholine synthesis CHKA PEMT CHAT PCYT1A PDHA1 ACHE MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260211%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 IL6ST TP53 BAX STAT3 CDH1 MYC SOCS3 E2F1 MMP9 CHI3L1 AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260211%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis CSN2-1 EIF4E RPS6KB1 EIF4A2 PRKAG1 EIF4G1 PRKAG2 MTOR PRKAA2 PRKAG3 RPTOR MLST8 EEF2 PRKAB2 CSN1S1 PRKAB1 EEF2K TSC2 PRKAA1 CSN3 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260211%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis TLR4 APOE SPI1 NFKB2 TLR2 TRAF6 IRAK1 RELA GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway NFKB2 CPEB4 CDKN1C EPB41L4B IL11 AKAP13 ENC1 ANKRD1 FGFBP1 TNFAIP3 EDN2 TSC22D3 SERPINB9 B3GNT5 CDC42EP3 CCL13;CCL2 PMP2 ANGPTL4 MFGE8 THBD JUN NR1I3 NR1I2 FGD4 SNAI2 HSP90AA1 GPR153 DNER SERTAD2 CCL20 CUL1 CAVIN2 KTN1 RXRA ETNK2 NR3C1 ACKR3-2 AMIGO2 SCNN1A PTGS2-2 SLC26A2 PDE4B ABHD2 PPP1R14C DNAJC15 BHLHE40 GADD45B ARL5B ZIC2 MGAM SRGN TGFBR3 NAV3 ADGRF4 BIRC2 BIRC3 PTGES3-1 ALOX5AP PRRG4 STOM TNS4 SPRY1 S100P LRRC8A RGS2 POU5F1;POU5F1B SEC14L1 SLC19A2 PLK2 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260211%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation NFKBIA PTPN6 SH2B3 DGKZ MAP4K1 PDPK1 PRKCQ GRB2 TNFAIP3 ITK SH2D1A MEF2D PLCG1 GRAP2 NFKB1 SMARCB1 LCP2 CARD11 RHOH BCL10 MALT1 LAT AGO3;AGO1 CDKN1B RNF7 REL CUL5 IKBKG NDUFB10 PIK3R2 PIK3R1 CD3G CD28 CD247 CD3E CD3D CHUK RASA2 MAP3K14 DGKA AKT1 TMEM222 ARIH2 UBASH3A TRAF6 ZFP36L1 RPRD1B FIBP CD5 LCK IKBKB CD8A CBLB VAV1 ZAP70 MAP3K8 PCBP2 ELOB SOCS1 GNA13 RELA OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260211%WP322%HOMO SAPIENS Osteoblast signaling SLC17A2 FGF23 PTH COL1A1 ITGAV TNFSF11 TNFRSF11B PDGFRB PDGFRA ITGB3 IBSP PTH1R PDGFB DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases HEXA GLA GM2A PSAP NEU1 NEU2 GBA NPC1-1 NPC2 GLB1 LIPA SCARB2 GALC NEU3 ARSA HEXB NEU4 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260211%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits CXCR4 TNC VCAM1 CYTIP PIK3CG LEF1 TCF7 VHL VEGFA TCF7L2 TCF7L1 NOTCH1 SRC JAG1 POSTN EPAS1 WNT2 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260211%WP100%HOMO SAPIENS Glutathione metabolism GPX4 GCLC ANPEP GCLM OPLAH GSTT2B;GSTT2 GSTM1;GSTM2-1 GSTA3;GSTA1 GSTA3;GSTA5;GSTA1;GSTA2 GGT1 G6PD GSR GGT5 GSS GPX1 IDH1 STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260211%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling NR1H2 LPIN1 FGF21 SIRT1 NFYA-1 CAMP ACLY RBP4 LPL SREBF2 SP1 GSK3A ACACA FASN PPARGC1B ACSS1 GPAM YY1 LDLR MDH1 CYP51A1 SREBF1 PRKACA-1 ATF6 PRKAG1 MBTPS1 PRKAG2 PRKAA2 IDI1 PRKAG3 FDPS LSS HMGCS1-1 INS;INS-IGF2 CREB1 MVD PRKAB2 AKT1 PRKAB1 PIK3CA SAR1B MBTPS2 PRKAA1 SCD MED15 SEC23A SQLE SEC13 KPNB1 SCARB1 SAR1A INSIG2 RNF139 SCAP MTOR SEC23B SEC31B SEC31A HMGCR SEC24B AMFR SEC24D-1 SEC24C PPARG SEC24A FDFT1 INSIG1 CDK8 HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260211%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness ZEB1 DICER1 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260211%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection IRAK4 IRF9 IFNAR1 TBK1 MYD88 TMPRSS2 DDX58 IFIH1 STAT1 ACE2 IRF3 TLR3 MAVS TLR9 STAT2 TRAF3 TLR7 IRF7 TRAF6 EIF2AK2 TLR4 TYK2 TLR2 TLR6 TREML4 JAK1 IFNAR2 IKBKE OAS1 OAS3 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260211%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy PFKFB2 MAP2K2;MAP2K1 SLC16A3 RPTOR MITF SLC2A1 GLS MLST8 PGLS MAPK1 MAPK3 BRAF GPX4 RPS6KA3 PKM DLAT RPS6KA1 SLC16A1 RAF1 RPS6KA2 PKLR CPT1A DLD MTOR TRAP1 SLC1A5 LDHB NAMPT ARAF PPARGC1A LDHA ACSS1 G6PD GSR PDHA1 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260211%WP1993%HOMO SAPIENS Angiogenesis overview FGFR1 SLIT2 PRKCA MAP2K2;MAP2K1 SHC1-1 SHB FRS2 VHL KDR MAPK8 PDPK1 GRB2 SOS1 GRB14-1 PXN TIMP2 MMP9 ELK1 NRP1 MMP2 PLCG1 MAP2K4 BMX RAF1 MAPK11 PLXND1 MMP14 WAS GRB7 SEMA3A RAC1 ANGPT1 PAK1 PIK3CD ROBO1 VEGFA TEK MAPK1 AKT1 ROBO4 MAP2K6 CRK DOK2 MAPK14 PLA2G1B IQGAP1 PTK2B NOX4 KRAS ATF2 BAD MTOR APC FGF1 CDC42 NCK1 NOS3 TIMP4 SRC SEMA4A MAP3K7 DAG1 F2 PTPN11 CCL18 SIGNALING%WIKIPATHWAYS_20260211%WP5097%HOMO SAPIENS CCL18 signaling MMP2 PTK2B CDH2 AK4-1 CCR8 ZEB2 ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP5276%HOMO SAPIENS Estrogen metabolism HSD17B10 HSD17B7 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HSD17B2 CYP19A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HSD17B3 HSD17B4 HSD17B8 HSD17B1 CYP1A2 CYP1B1 COMT LAC PHE PATHWAY%WIKIPATHWAYS_20260211%WP5239%HOMO SAPIENS Lac Phe pathway ABCC5 CNDP2 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260211%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition BUB3 BUB1 SMC1A PTTG1;PTTG2 BUB1B STAG1 MAD1L1 APC ESPL1 CDC20 SMC3 CENPE RAD21 MAD2L1 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260211%WP334%HOMO SAPIENS GPCRs class B secretin like GLP1R PTH2R ADGRE1 CALCR ADGRG2 ADGRL4 CRHR2 ADGRE5 ADGRL2 ADGRL3 PTH1R VIPR1 CRHR1 ADCYAP1R1 CALCRL VIPR2 GIPR GCGR GLP2R GHRHR SCTR ADGRL1 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260211%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways PHGDH MTHFR CTH GCLM SOD3 DMGDH AHCYL1 AHCY SLC25A48 PLD1 CSAD BHMT2 AMT DHFR2;DHFR GPX7 MTHFD2L PCYT1A MTHFD1L CDO1 GNMT SARDH AHCYL2 MTHFD1 SHMT1 TYMS BCAT2 DNM1 BAAT GAD2 GPX5 DNMT3L BCAT1 ALDH7A1 ETNK2 DNMT3A GSR GCLC MAT2B MAT2A GAD1 CHDH BHMT PCYT1B CHKB PCYT2 CHKA ETNK1 PEMT CHPT1 CEPT1 DNMT3B AGXT2 CBS;CBSL GPX1 GPX4 SOD1 GPX6 MTR-1 PSPH MTHFD2 MAT1A PSAT1 SHMT2 GSS 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome NOG SF3B1 DDX21 JUND MAPK8 FRMPD2 OGDHL FAM170B SLC18A3 VSTM4 SIRT1 C10orf71 RGMB BAZ1B WDFY4 PARG ARNTL LRRC18 NLRP3 CHAT ARHGAP22 SMAD1 HSF4 DRGX ELK1 KDM4D SMAD5 C10orf53 SMARCA5 MYO1C DEK TMEM273 UVSSA MYBBP1A EIF4ENIF1 CDH1 SMARCB1 DLD BMPR1A SMARCC2 ELOA BMP2 BCL2 CUL5 ERCC5;BIVM-ERCC5 GDF5 ERCC8 NEO1 RIF1 ERCC6 HSF1 PCNA ATF2 CLOCK DLST SIRT6 MEN1 SMAD9 ITCH BMPR1B MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260211%WP2857%HOMO SAPIENS Mesodermal commitment pathway TRIM5 ZIC3 JARID2 TEAD1 TEAD2 NOG PARP8 CSRP2 TOX3 DDAH1 AEBP2 SMAD2;SMAD3 MTF2 AHDC1 IQCJ-SCHIP1;SCHIP1 ASCC3 ZNF462 CTBP2 ELP4 GRHL2 SRF AMH FOXC2 BMP7 FOXC1 KLF4 MIXL1 BMP4 PITX2 ADAM19 TWSG1 MACF1 HAND1 CHRD CCDC88A PAX6 MSGN1 ARL4A WDCP TBX6 CRTC1 LEF1 FOXA1 KDM6A ACACA TBX3 TCF4 TCF7L1 HMGA2 FOXA2 TET1 DKK1 ARID5B ACVR2A GATA3 GATA6 PLCH1 KLF5 TBX1 FOXH1 BHLHE40 TRIM28 LEFTY2;LEFTY1 RARB FZD5 YAP1-1 NABP2 FZD8 PPP2CB;PPP2CA JAK2 FGF8 CCND1 POU5F1;POU5F1B FZD4 FGFR1 PIAS1 PRKAR1A DLL1 SOX2 CCDC6 SLC2A12 C1QBP SMAD1 SMAD6 EXT2 SMAD4 HES7 SNAI1 BMPR1A MEIS1 BMPR2 HTT RPL38 ACVR1 SESN1 WNT3 ACVR2B WNT3A INHBA NFE2L2 PRKACA-1 SOX21 HNF4A SOX17 AXIN1 CEP250 DIP2A ZIC2 EOMES AXIN2 WDHD1 DNMT3B ELK4 ZNF281 EMSY WDFY2 HPRT1 BCORL1 TOX NLK SETD2 MBTD1 EPB41L5 UBR5 ATP8B2 PBX3 GDF3 ZFHX4 TRERF1 PBX1 VAV3 EXT1 NANOG;NANOGP8 C9orf72 NODAL RGS10 TRIM71 RARG NCAPG2 CUL4B PHF6 LATS1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260211%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway H4C1 MED23 TAF8 MED27 TAF2 TBP TAF13 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260211%WP186%HOMO SAPIENS Homologous recombination POLD1 NBN ATM RAD54B MRE11 RAD50 RAD52 RAD51 BRCA2 RPA1 POLD3 POLD4 POLD2 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260211%WP2113%HOMO SAPIENS Type III interferon signaling IRF9 TYK2 IL10RB STAT2 JAK1 IFNL2;IFNL3;IFNL1 IFNLR1 STAT1 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260211%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system ACAD9 NDUFS6 NDUFS4 NDUFAF1 NUBPL NDUFS2 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 TIMMDC1 NDUFA13 NDUFC2;NDUFC2-KCTD14 NDUFAF2 NDUFV3 NDUFV2 NDUFV1 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFS3 NDUFA3 NDUFAB1 NDUFB11 DMAC2 NDUFS5-1 FOXRED1 TMEM186 TMEM70 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF3 TMEM126B NDUFA12 NDUFA10 ECSIT NDUFC1 SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260211%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260211%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer NRAS PARP2 MAP2K2;MAP2K1 INPP4B AR PIK3R1 GRB2 RPTOR SOS1 DEPTOR MLST8 IRS1 AKT2 SOS2 TELO2 AKT3 MAPK1 AKT1 MAPK3 PIK3CA BRAF MAPKAP1 RPS6KB1 PRR5L KRAS AKT1S1 RAF1 MTOR HRAS PTEN PARP1 ARAF EIF4EBP1 RICTOR TSC2 PDK1 TSC1 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260211%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3C2G PIK3C2A PIK3C2B PIK3CG PIK3R4 PIK3CD PIK3R2 PIK3R1 PIK3CB PIK3R6 PIK3R5 PIK3R3 PIK3CA SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260211%WP1455%HOMO SAPIENS Serotonin transporter activity IL1R1 TGFB1I1 SCAMP2 IL1B PPP2CB;PPP2CA NOS1 SLC6A4 TPH2 ITGB3 STX1A MAOA NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260211%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum RFC2 H3-3A POLE4 ERCC4 ERCC1 ERCC2 HMGN1 XAB2 UVSSA CDK7 LIG3 CUL4A USP7 BRCA1 POLH SLX4IP DDB1 CETN2 XPA RFC1 XPC RAD23A GTF2H2C;GTF2H2C_2;GTF2H2 CCNH DDB2 ERCC8 GTF2H1 GTF2H3 GTF2H4 RFC3 ERCC3 RFC4 RBX1 MNAT1 RPA2 RAD18 POLK RPA3 ERCC6 RPA1 POLD3 RAD23B POLD4 POLD1 POLE LIG1 PCNA XRCC1 CHD1L POLE2 POLE3 H4-16 PARP1 SLX4 GPS1 H4C1 H4C6 CUL4B POLD2 RFC5 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome SKI TNFRSF4 TGFB1 COMMD1 MCM2 TNFSF4 TRIM25 TNFRSF14 DLL1 SMAD2;SMAD3 CD160 LRP4 ARF6 PRKCZ B3GALT6 ESR1 SMAD4 ISG15 C1QTNF12 HES5 UBE2J2 MMP23B GNB1 CALML6 HSPA8 DVL1 INTS11 VTN PANK4 INTS13 TNFRSF18 INTS14 INTS10 CDK11A;CDK11B GDE1 GRIK2 TMEM52 NOC2L OR4F21;OR4F16;OR4F29;OR4F3 ATAD3A;ATAD3B METTL14 SDF4 PLEKHN1 CCNL2 SAMD11 MUSK PLCH2 OR4F5;OR4F17;OR4F4 IFIH1 SSU72 PEX12 ELAVL1 PEX2 ACAP3 RER1 RBX1 SCNN1D VEGFA CPTP PEX5 MXRA8 VWA1 AGRN TRAF2 AURKAIP1 DKK3 TRAF5 PERM1 KLHL17 MEPCE PUSL1 TAS1R3 NADK HES4 TNFSF18 CFAP74 GABRD MIB2 PEX10 PARD6B RNF223 CUL3 MORN1 FNDC10 ANKRD65 INTS9 SLC35E2B C1orf159 IFIT1 DLST PHKG2 MRPL20 INTS4 KRT17 BTLA DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260211%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens PHB2 GDF15 EIF2A MARS1 SLC7A7 OMA1 CLPP LARS1 SESN2 LONP2 MTOR PHB TRAP1 HSPD1 ATF4 IRS1 MYC AKT1 TSC2 TSC1 FOXO1-1 LONP1 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260211%WP5145%HOMO SAPIENS COVID 19 structural coverage map PAIP1 TOMM70 MPP5 PARP14 ACE2 UPF1 UBB;UBC SLC6A19 NRP1 ISG15 TAB1 IGHMBP2 MRM2 MACROD1 MACROD2 PARP9 CMTR1 UBA52 UPF2 GDAP2 NLRP12 APOA1 MACROH2A1 MACROH2A2 AQR NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling PTK2 NRAS MAP2K2;MAP2K1 EGFR FN1 MAPK10 COL1A1 PIK3CD MAPK9 MAPK8 GRB2 SOS1 PXN AREG ITGA1 AKT3 MAPK1 MAPK14 ITGB1 KRAS MAPK12 RAF1 MAPK13 MAPK11 HRAS SRC TLN1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260211%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance ACSL1 MAFA ERN1 RPS6KB1 PPP2CB;PPP2CA SLC2A4 PIK3R1 MAPK8 PRKAG3 TRAF1 INS;INS-IGF2 IRS1 IRS2 PRKCZ TNF TNFRSF1A SMPD3 AKT1 CPT1B INSR PDX1 CD36 EIF2AK2 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260211%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 PYCARD IL1B NLRP3 NFKB1 TRAF3 RELA CASP1 NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma NOTUM CSNK1A1 WNT7B WNT7A CHD8 CTNNB1 CTBP2 CCND2 NKD1 NKD2 KLF4 CTBP1 SOST SFRP1 WNT5B WNT5A FOSL1 JUN PLAU LEF1 TCF7 TCF7L2 TCF7L1 WNT6 FZD10 DVL1 FRAT2 DVL2 CSNK2A2 DVL3 SFRP2 DKK1 DKK2 WNT1 CCND3 DKK4 WNT2 EZH2 SFRP4 WNT3 WNT4 CSNK2B WNT3A TPTEP2-CSNK1E;CSNK1E GSK3B WNT2B MTDH ELAVL1 SOX17 AXIN1 FZD1 RYK-1 WNT10B MYC CER1 ROR1 WNT10A FZD3 WNT16 FZD2 FZD5 SOX7 FZD7 WIF1 FZD6 FZD9 FZD8 LRP5 ROR2 NLK LRP6 WNT11 APC SERPINF1 CCND1 CTNNBIP1 KREMEN1 SENP2 SFRP5 CSNK2A1;CSNK2A3 CXXC4 PORCN UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260211%WP4925%HOMO SAPIENS Unfolded protein response PPP1R15A DDIT3 BCL2 EIF2S1 ERN1 NFE2L2 CASP2 ATF6 MBTPS1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BID PMAIP1 TP53 ATF4 RTCB IL1B TXNIP XBP1 HSPA5 MBTPS2 EIF2AK3 BBC3 BCL2L11 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260211%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair XRCC6 NBN SETD2 ATM RAD54L NASP-1 SUPT16H H4-16 XRCC5 SSRP1 MDC1 RAD51 NAP1L1 PRKDC RNF168-1 H4C1 RNF8 H4C6 TP53BP1 PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260211%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 CYCS-1 BIRC3 BAX CASP7 PPP2CB;PPP2CA CASP9 CASP3 FADD TRADD TRAF2 TNF CASP8 TNFRSF1A RIPK3 RIPK1 MTHFR DEFICIENCY%WIKIPATHWAYS_20260211%WP4288%HOMO SAPIENS MTHFR deficiency EHMT2 CYCS-1 ASMT EHMT1 MTHFR GRIN2D MARS1 CHDH ALDH7A1 BHMT PCYT1A CASP9 GRIN2A GRIN1 CHKA HNMT CASP3 DNMT1 NDUFAF7 PEMT CHPT1 DNMT3B DNMT3A COMT 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260211%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome RAB4A CD19 ATP2A1 KDR C3-1 GRB2 CD82 CD81 TRAF1 RABEP2 TRAF2 IL4 CR2 INSR NFATC2 MPL RAB5A JAK2 VAV2 LAT RABGEF1 PRMT1 NFATC2IP TUFM SH2B1 ATXN2L SPNS1 IFITM3;IFITM2;IFITM1 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260211%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation SMAD4 SMURF1 RUNX2 BMP2 NOG TOB1 SMAD1 TOB2 BMPR1A SMAD6 BMPR2 BMPR1B RANKL RANK SIGNALING%WIKIPATHWAYS_20260211%WP2018%HOMO SAPIENS RANKL RANK signaling PTK2 NFKBIA MAP2K2;MAP2K1 NFKB2 MAPK9 MAPK8 MITF PLCG1 SPI1 JUN NFKB1 TAB1 TNFRSF11B FHL2 RAC1 PAPSS2 MAP2K7 TNFRSF11A RELB TAB2 IKBKG PIK3R2 PIK3R1 STAT1 FOS CHUK TRAF1 NFATC1 TRAF2 AKT2 TRAF5 MAPK1 AKT1 TRAF3 MAPK3 TRAF6 MAP2K6 SYK MAPK14 LYN IKBKB TNFSF11 MTOR SQSTM1 GAB2 CDC42 SRC MAP3K7 CBL RELA TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260211%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals GCLC CEBPB EPHB2 GCLM PRKCA NFE2L2 NQO1 MAPK8 MAF GSTA3;GSTA5;GSTA1;GSTA2 SLC7A11 HMOX1 KEAP1 AIMP2 PIK3CA INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260211%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy RAB4A GDAP1 EGR2 FIG4 MPZ RAB11A HSPB1 RAB3B RAB3A DNM2 NDRG1 MFN2 KIF1B RABAC1 RAB7A FGD4 PMP22 NEFL RAB11B SBF2 LRSAM1 HSPB8 MTMR2 LITAF SH3TC2 RAB25 RAB4B ONE CARBON METABOLISM%WIKIPATHWAYS_20260211%WP241%HOMO SAPIENS One carbon metabolism ST20-MTHFS;MTHFS MTFMT MTHFR GLRX MAT2B FOLH1B;FOLH1 AHCY TCN2 AMT DHFR2;DHFR CHDH BHMT MTHFD1L ALDH1L1 AHCYL2 FTCD MTHFD1 SHMT1 TYMS DNMT3B MTRR MTR-1 ATIC MTHFD2 DNMT1 GART MAT1A DNMT3A SHMT2 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260211%WP5399%HOMO SAPIENS NPHP1 deletion syndrome FLNB BCAR1 PTK2B MAPK1 INVS MAPK3 RPGRIP1L FLNA NPHP1 FLNC N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5153%HOMO SAPIENS N glycan biosynthesis DPAGT1 ALG6 MGAT4A-1 MPI GMPPB MAN1A2 GMPPA MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 ALG5 ALG2 ALG14 ALG3 MOGS ALG12 ALG11 DDOST DPM3 DAD1 MAN1B1 RPN2 RPN1 GANAB MAN2A2 MAN2A1 GPI MGAT5 MAN1C1 MGAT3 MGAT2 MGAT5B-1 SRD5A3 DOLK MGAT4C MGAT4D DOLPP1 MGAT4B STT3A STT3B ALG10;ALG10B FUT8 PMM2 B4GALT3 ALG1 B4GALT1 MPDU1 MGAT1 TUSC3 DPM1 DPM2 B4GALT2 RFT1 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260211%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions LATS2 CD19 TEAD1 TEAD2 TEAD3 YWHAQ RASSF5 RAP1A CCR7 FOXP3 STK38L RHOA YAP1-1 FYB1 WWTR1 NDRG1 FOXO1-1 MAPK14 FOXO4 MST1 PRDM1 ITGAL LPL FOXO6 KNSTRN-1 RAB13 FERMT3 SAV1 FOXO3 MOB1A;MOB1B RAC1 TEAD4 STK3 LATS1 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260211%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 IRAK4 TOLLIP REL RELB TBK1 MYD88 IKBKG NFKB2 IRF3 TLR8 TLR3 CHUK TLR5 MAPK1 TLR9 TRAF3 TLR7 IRF7 TRAF6 TLR4 NFKB1 TLR2 IKBKB TLR1 TLR6 TICAM2 TIRAP TICAM1 IRAK1 IKBKE RELA REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling RBCK1 NFKB2 MAPK10 MAPK9 MAPK8 CYLD CASP8 PIK3R3 MAP2K3 MAP2K4 TREM1 MAPK12 MAPK13 CCL5 MAPK11 TMED7 TLR1 TLR6 CCL4L2;CCL4L1;CCL4 RIPK1 TICAM1 IKBKE CD86 CD40 CD80 TBK1 IKBKG IL12B IL12A PIK3R2 PIK3R1 CXCL11 IRF3 TLR8 TLR3 FADD MLST8 AKT2 IRAK3 PELI1 IFNB1-4 AKT3 PELI2 TLR9 MAPK1 AKT1 TRAF3 TLR7 MAPK3 TRAF6 TLR4 PIK3CG IKBKB CISH SQSTM1 LBP PIK3R5 SOCS1 ZMYND11 IFNAR2 RELA CD14 NFKBIA IFNAR1 PTPN6 MAP2K2;MAP2K1 TNFAIP3 CXCL9 TNF CXCL10 PLK1 IRF7 RNF216 CCL3L1;CCL3L3;CCL3;CCL18 SMAD6 IRF5 MBL2-1 JUN NFKB1 TAB1 TLR2 IL6 USP7 FBXW5 CD180 TICAM2 TRAFD1 SIGIRR CUEDC2 SFTPD RAC1 TIRAP RNF31 PELI3 CTNNAL1 SARM1 IRAK1 MAP2K7 IRAK2 IRAK4 TOLLIP SPP1 TAB3 TAB2 MYD88 OTUD5 LY96 PIK3CD PIK3CB STAT1 RNF41 FOS CHUK IL1B TLR5 TIFA CXCL8 PIK3CA MAP2K6 SYK MAPK14 BTK MAP3K8 MAP3K7 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260211%WP530%HOMO SAPIENS Cytokines and inflammatory response TGFB1 IL12B CSF2 IL11 CD4 IL7 IFNG IL10 PDGFA IL13 CSF1 IL2 IL4 IL1B IFNB1-4 IL5 TNF CXCL2;CXCL3;CXCL1-1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 IL3 IL6 IL15 HLA-DRA IL1A CSF3 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260211%WP183%HOMO SAPIENS Proteasome degradation PSMB6 PSMB7 PSMB4 PSMB9 PSMB5 PSMB2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PSMB3 PSMB1 PSMA2-1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 RPN2 PSMD2 RPN1 UBB;UBC PSMD3 PSMD1 PSMC2-1 PSMD10 UBE2D3-1 PSMD12 PSMD11 UBA7 UCHL1 PSMD13 UBE2D1 H2AC4 UCHL3 PSME3 PSME1 PSME2 PSMB10 UBE2B PSMB8 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 UBA1 NEDD4 IFNG H2AZ2;H2AZ1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBE2D3;UBE2D2 PSMA7 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260211%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RARA RXRA VDR SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260211%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways SNAP25 NFKB2 PAH SLC6A4 HSPD1 AQP4 AVP KCNQ1 NFYA-1 MEF2C MAZ PHOX2B ACADM CHAT ECE1 HIF1A HTR1A CTCF VAMP2 FEV SLC1A3 BDNF NKX3-1 SCN3B KCNH2 DLX2 POU2F2 TF SNTA1 DDC TAC1 SCN4B HES1 MAOA HES5 CHRNB2 PPARGC1B CREBBP YBX1 NEUROD1 CHRNB4 POU3F2 EN1 EP300 CREM CEBPB GATA3 GATA2 LOC110384692;C4A;C4B_2;C4B IL6R SST TH BHLHE40 FOXM1 TP73 ALDOA TLX3 MAP2 GABRA1 MYB NTRK2 TACR1 CHRM2 RUNX3 HTR2A IL1A GJA1 SSTR1 POU5F1;POU5F1B AR HSP90B1 PRKAR1B PRKAR1A SSTR2 GRIN1 FMO3 CTNNB1 SOX2 IL1RN TNF PRKAR2B TPPP PRKAR2A ASCL1 JUN NKX2-2 NFKB1 IL6 TPH2 SP1 TPH1 PLP1 NGF G6PC1 GNB3 CAV3 REST NR3C1 YWHAE ESR2 RYR2 YWHAB CHRNA4 GCK RORA PKNOX1 TSPYL1 HADHA GPD1L-1 HADHB-1 PRKACA-1 ADCYAP1 YWHAQ DEAF1 SPTBN1 PHOX2A HDAC1 CC2D1A YWHAG CDCA7L YWHAH RET GAPDH-1 IL10 HTR3A NOS1AP VEGFA CASP3 YWHAZ ATP1A3 IL13 KCNJ8 MBD1 LMX1B CREB1 IL1B CXCL8 HDAC9 SLC25A4 SP3 CHRNA7;CHRFAM7A THRB SLC9A3 CPT1A PRKACB-1 PBX1 NANOG;NANOGP8 PPARGC1A EGR1 VIPR1 ADCYAP1R1 VIPR2 SCN5A MECP2 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C18-1 CYP2B6 CYP2C9;CYP2C19 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation SFN RAF1 ZP2 RHBDD2 POR YWHAG LMNA SRRM3 DAPK2 HSPB1 TMEM120B TMEM120A SSC4D STYXL1 PTPMT1 KIF1C ZP1 G3BP1 ZP3;POMZP3 MDH2 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260211%WP585%HOMO SAPIENS Interferon type I signaling IFNAR1 PTPN6 STAT3 PIAS1 EIF4A1 RACK1 RAP1A IRS1 IRS2 MAP3K1 STAT2 EIF4E STAT5A MAPKAP1 MAP2K3 TYK2 PTPRC RAC1 JAK1 IRF9 REL STAT4 PIK3CD PIK3R2 PIK3R1 STAT1 RPTOR MLST8 CREB1 EIF4B CRKL RPS6 MAP2K6 CRK RAPGEF1 MAPK14 RPS6KB1 LCK PIAS3 MTOR GAB2 RPS6KA4 VAV1 RPS6KA5 ZAP70 PRMT1 SOCS3 SOCS1 CBL EIF4EBP1 PDCD4 IFNAR2 FYN PTPN11 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260211%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway GPAT4 CDIPT PIP5K1A GNPAT PLA2G2A-1 IPMK PIK3CD AGPS PIK3CB LPIN1 LPIN2 CHKB PCYT2 GK PTDSS1 GPAT3 PEMT CHPT1 CEPT1 PI4K2A PTPMT1 PIK3CA MOGAT3 PGS1 GPAT2 CDS2 PIK3CG GPD1 GPAM CRLS1 RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260211%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation EPHB2 GRK1 PIK3CG AKT1 PIK3CA PIK3CD MTOR PIK3CB CMKLR1 LTB4R PDK1 FPR2 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260211%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy SLC2A1 GPAT3 PPARG LDHA TPI1 GPD1 CD36 HIF1A GAPDH-1 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260211%WP404%HOMO SAPIENS Nucleotide metabolism OAZ1 POLD1 HPRT1 RRM1 DHFR2;DHFR POLG RRM2B PRPS1 ADSL POLA1 RRM2-1 SRM MTHFD2 IMPDH1 ADSS2 SAT1 NME2 POLB PRPS2 FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5102%HOMO SAPIENS Familial partial lipodystrophy SREBF1 CEBPA GATA3 PNPLA2 GATA2 KLF2 MAPK9 KLF5 FABP4 CIDEA LIPE PPARA INS;INS-IGF2 AKT2 PIK3CA FNTA LMNB1 BANF1 STAT5B CIDEC LPL ZMPSTE24 KLF9 LMNA LMNB2 ICMT PRRX1 PPARG PLIN1 MGLL SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260211%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway CTSV;CTSL SCARB1 TMPRSS2 FURIN TLR7 ACE2 SLC6A19 ACAT1 NRP1 TMPRSS4 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260211%WP325%HOMO SAPIENS Triacylglyceride synthesis DGAT2 DGAT1 MOGAT2 MOGAT1 GNPAT AGPAT1 AGPAT3 PNPLA2 AGPAT5-1 LPL AGPS GPD1 GK2 LIPF GK LIPE AGPAT2 LIPC GPAM MOGAT3 PLPP3 PLPP2 PLPP1 AGPAT4 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260211%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB IL1A TIFA UBE2V1 PRKCZ NFKB1 AJUBA TRAF6 UBE2N SQSTM1 IRAK1 SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260211%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling NRAS MAP2K2;MAP2K1 KRAS RAF1 RASGRF1 MAPKAPK2 HRAS HTR2B GNAQ GATA4 HTR2A ITPR1 SRF MAPK1 RASGRP1 ELK4 MAPK3 ELK1 MAPK CASCADE%WIKIPATHWAYS_20260211%WP422%HOMO SAPIENS MAPK cascade NRAS MAP3K12 MAP2K2;MAP2K1 MAPK10 RASA3 GRB2 SOS1 RRAS PLCB3 SOS2 MAPK1 MAP3K2 MAP3K1 MAPK3 ELK1 MAP2K6 BRAF MAPK14 MAP2 MBP MAP2K3 MAP3K3 MAP2K4 KRAS JUN MAPK12 RAF1 LAMTOR3 SIPA1 HRAS ARAF MAP2K7 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260211%WP3287%HOMO SAPIENS Overview of nanoparticle effects PTK2 BCL2 BAX FN1 PTGS2-2 NFRKB PIK3CD IL6 PTGS1 ITGAD HMOX1 AKT3 CXCL8 TNF CDH3 CRP LAMA3 CCND3 COL4A1 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260211%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing DDX58 RNASEH2C CGAS RNASEH2B IFIH1 RNASEH2A ADAR RNASET2 STING1 SAMHD1 IRF3 TREX1 MAVS RNASEL IFNB1-4 OAS1 CILIOPATHIES%WIKIPATHWAYS_20260211%WP4803%HOMO SAPIENS Ciliopathies CEP19 CCNQ CCNO AK7 CCDC65 GLIS2 CEP78 DNAH11 ARL2BP DNAL1 HYDIN TAPT1 DYNC2H1 CCDC39 DDX59 CFAP52 ZNF423 DNAI2 POMGNT1 TOPORS NME9 ZMYND10 KIZ CFAP53 NEK9 KATNIP CCDC103 DYNLT2B DNAH6 POC1A POC1B USP9X RAB28 DNAI1 TUB RPGRIP1 DYNC2LI1 TTLL5 HYLS1 ATXN10 XPNPEP3 TRAF3IP1 CEP164 OCRL PKD2 FLCN IFT52 TMEM107 CNGA1 NEK1 BBS9 CEP120 BBS7 IFT57 BBS5 KIAA0753 TCTN3 CEP290 TCTN2 CSPP1 BBS4 OFD1-1 TCTN1 IQCB1 MKKS PIK3R4 CC2D2A IFT140 IFT80 RPGRIP1L CFAP410 TMEM138 WDR35 LZTFL1 ANKS6 EVC NPHP1 BBS10 IFT43 PIBF1 BBS12 RP2 MAK CPLANE1 TMEM216 TMEM231 EFHC1 WDPCP TMEM17 CILK1 KIAA0586 TMEM237 INVS CNGB1 CEP104 NPHP3 UNC119 ARL6 B9D1 ARL3 B9D2 PKD1L1 PKHD1 CRX ARL13B TMEM67 INPP5E RP1L1 EVC2 BBS2 INTU NEK8 BBS1 WDR19 TULP1 PCARE SCLT1 IFT172 LCA5 IFT122 DCDC2 C8orf37 TTC8 MKS1 PKD1 CEP41 TRIM32 DNAJB13 CLUAP1 TTBK2 CEP83 RSPH9 C2CD3 SMO IFT81 RSPH4A GPR161 GLI3 SPATA7 GLI2 ALMS1 IFT27 RSPH3 RSPH1 PLK4 CCDC40 NME7 CENPF BBIP1 KIF7 TTC21B ZIC2 PDE6D DRC1 ADCY6 RAB23 SPAG1 ODAD1 GALNT11 ODAD3 ODAD2 ODAD4 GAS8 MCIDAS TBC1D32 NEK2 DNAAF3 AHI1 DNAAF2 DNAAF1 DNAAF6 DNAAF5 DYNC2I2 DNAAF4 DYNC2I1 RP1-2 FAM161A CFAP298;CFAP298-TCP10L CHOLESTASIS%WIKIPATHWAYS_20260211%WP5238%HOMO SAPIENS Cholestasis ABCC2 SLC22A1 TJP2 NR1I3 SCARB1 HMGCR EPHX1 NR1H4 ABCC3 SLCO1A2 ABCB4 SLC10A1 RXRA ABCB11 ATP8B1 ABCC4 LDLR ABCG8 ABCG5 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260211%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances SLC25A13 SLC25A22 GLUD1;GLUD2 GOT2-1 SLC25A12 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260211%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis HSD17B6 HSD3B1;HSD3B2 CYB5A CYP11A1 HSD17B3 POR CYP17A1 SRD5A2 STAR FOLATE METABOLISM%WIKIPATHWAYS_20260211%WP176%HOMO SAPIENS Folate metabolism ST20-MTHFS;MTHFS MTHFR CTH SOD2 SOD3 HBA2;HBA1 AHCY NFKB2 DHFR2;DHFR ALB MTHFD1 SHMT1 CSF1 TNF CRP CCL13;CCL2 SLC46A1 IZUMO1R FOLR2 NFKB1 IL6 FOLR1 APOA1 RFK APOB LDLR IFNG INS;INS-IGF2 IL2 IL1B IL4 CBS;CBSL INSR FLAD1 GPX1 GPX4 SOD1 CAT SCARB1 SERPINA3 MTRR SERPINE1 GPX6 PLAT MTR-1 MPO ICAM1 SAA2;SAA1 TP53 MTHFD2 FGB GART FGA SAA2-SAA4;SAA4 FGG MAT1A F2 F7 SHMT2 PLG HBD;HBB RELA SLC19A1 ABCA1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260211%WP185%HOMO SAPIENS Integrin mediated cell adhesion BCAR1 CAPNS1 MAPK10 GRB2 RHO SOS1 PXN SORBS1 PAK2 MAP2K3 CAPN9 CAPN6 MAPK12 CAPN7 CAPN5 TNS1 GIT2 CAPN11 ARHGEF7 CAPN10 BUB1B-PAK6;PAK6 ARAF ILK PAK3 PAK4 RAC3 CAPN3 PIK3R2 RAP1B MAP2K5 AKT2 ITGA1 AKT3 MAPK1 AKT1 BRAF ITGAM CRK ROCK1 ROCK2 ITGB2 MAPK7 ITGB1 VCL MYLK2 ITGAX HRAS VAV2 SELENOP SRC FYN PTK2 MAP2K2;MAP2K1 SHC1-1 ITGB3 PDPK1 ITGA2B MAPK6 RAP1A MAPK4 ITGA10 ITGA11 SHC3 ITGA2 CAPN2 CAPN1 ITGB5 ITGB4 ITGAE RAF1 ITGAL ITGB8 ITGAV ITGB6 ITGA3 VASP ITGAD ZYX ITGA8 ITGA7 CAV3 RAC1 ITGA6 TLN1 ITGA5 ITGA9 DOCK1 MYPN PAK1 CAV2 MAP2K6 RAPGEF1 CAV1 ITGA4 CDC42 ITGB7 VAV3 CSK TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260211%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly CHAF1B H2BC15;H2BC3;H2BC11;H2BC12 RBBP4 SMIM40 H4C1 HIRA CHAF1A ATRX H4C6 H4-16 DAXX IL18 SIGNALING%WIKIPATHWAYS_20260211%WP4754%HOMO SAPIENS IL18 signaling PRKCB CYCS-1 NFKBIA PRKCD PRKCA MAPK9 BID IRF1 FAS MEF2A CTNNB1 TNF CASP8 NFKB1 IMP3 GATA1 SP1 SLC12A3 IL18R1 PTEN IL37 TICAM2 FASLG CFLAR IRAK1 MAP2K7 CSN2-1 CEBPB MYD88 IL18RAP GSK3B PIK3R1 ELAVL1 NCF1 CASP3 CHUK HSPB1 MAPK1 TNFRSF1A MAPK3 TRAF6 PRKAA1 NCF2 ACACB GRIN2B BAX NFATC4 RPS6KB1 NOX1 LCK IKBKB IL18 TP53 PARP1 MAP3K7 RELA NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260211%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium ID2-1 STAT3 HEY1 DISC1 DLL1 NRG1 CDK5R1 SOX2 MEF2C MAP1B NOTCH1 PAFAH1B1 ASCL1 BDNF PAX6 GHRL ID1 PLXND1 FAIM PSEN1 HES1 LRP8 KDM1A NEURL1 TCF4 NEUROG3 NGF RTN4 APP VLDLR NEUROD1 ERBB4 NDEL1 CDK5 GSK3B RET RTN4R CXCL12 DAB1 NGFR AGRN MYC IL17A MAP2 NTRK1 NTRK2 NTRK3 MRE11 RELN NUMB NUMBL MARK2 SEMA4A MAPT JAG1 MECP2 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260211%WP2795%HOMO SAPIENS Cardiac hypertrophic response TGFB1 PRKCA MAP2K2;MAP2K1 MAP4K1 MAPK8 PDPK1 PRKD1 NRG1 MEF2A TNF MAP3K1 EGF CDK7 MAP2K3 FGFR2 MAP2K4 RAF1 NFKB1 LOC118142757;GUCA1A RAC1 CALM1 IKBKE MAP2K7 PLA2G2A-1 IKBKG GSK3B TGFBR1-1 CHUK MAP2K5 MAP3K14 PRKG1 AKT2 HDAC4 MAPK1 AKT1 TNFRSF1A HDAC5 MAPK3 CAMK2D HDAC9 MAP2K6 HDAC7 IGF1 MAPK14 NFATC2 MAPK7 CDK9 IKBKB PPP3CA MTOR MAP3K7 FGF2 NPPA 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome SNAP25 CLTC GRB2 FBN1 UBE2L6 GRIP1 BAZ1B BRD4 VAMP2 STX1A SMARCA5 MYO1C DEK HDAC6 MYBBP1A DLD ACACA UBE2E3 UBE2E1 CLIP2 HDAC2 DNAJC30 USF1 FKBP6 VPS28 FBLN2 FBLN5 TBL2 GTF2IRD1 BCL7B BUD23 VPS9D1 HSPA2 VPS37C VPS37D VPS37A VPS37B EIF2A METTL27 ULK1 ATPAF1 MVB12A CLASP2 CFL1 TRIM74;TRIM73;TRIM50 TMEM270 OGDH MYC MAPK3 EIF2AK3 FZD9 CLDN1 CLDN3 LIMK1 SQSTM1 RB1 RFC5 RFC2 SF3B1 CDKN1C DDX21 HOXC8 NRG1 FAS ATF4 CTNNB1 TSG101 PKLR UBIAD1 ABHD11 EIF4H WNT2 CHTF18 NUP62 CLASP1 GAPDH-1 ATP5MC2 LAT2 ATP5MC3 PRKG1 ATPAF2-2 ATP5MC1 GTF2I ATP5F1A ERCC6 ATP5F1B CLDN5 ACACB BECN1 BTK PCNA ATP5PB ATP5F1D CLDN4 ATP5PO DLST HDAC3 TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders FAH GSTZ1 HGD HPD TAT NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260211%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 PRKCB PRKCE PRKCD NRAS PRKCA NFKB2 IFNGR2 MAPK9 IFI44L MAPK8 PRKCQ TNF PRKCZ STAT2 CAMP CCL13;CCL2 PLCG2 MED1 ISG15 JUN MAPK12 TYK2 MAPK13 TLR2 NFKB1 MAPK11 IL6 SP1 CYP27B1 ETS1 RXRA CYP24A1 JAK1 VDR DEFB4A;DEFB4B CD40 NOD2 RELB IFI27L2 STAT1 CD40LG RSAD2 IFNG TLR8 IFNGR1 PLCB3 CXCL8 CAMK2B MAPK1 TNFRSF1A MAPK3 PLCE1 CAMK2D RXRB RXRG MAPK14 CAMK2A TLR4 MAPK7 SP3 KRAS IKBKB CAV1 HRAS CAMK2G PLCB4 PRKCG PLCB1 PLCD1 IFNAR2 PLCB2 PRKCH COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260211%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 IL17RC IL17A IL17RA ANO6 SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260211%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD NFKBIA CHUK AGER THBD IKBKG NFKB1 IKBKB HMGB1-1 RELA MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260211%WP391%HOMO SAPIENS Mitochondrial gene expression MYEF2 POLRMT TFB1M TFB2M PPRC1 PPP3CA GABPB1 GABPA SP1 MTERF3 ESRRA MTERF1-1 NRF1 TFAM-1 HCFC1 PPARGC1B CREB1 PPARGC1A CAMK4 DNA REPAIR PATHWAYS FULL NETWORK%WIKIPATHWAYS_20260211%WP4946%HOMO SAPIENS DNA repair pathways full network SMUG1 WRN ERCC2 XRCC4 POLM LIG4 NHEJ1 LIG3 RAD54B TDG POLH CETN2 XPA XPC MGMT RAD23A ERCC5;BIVM-ERCC5 ERCC8 RBX1 REV3L POLI DCLRE1C EXO1 RPA3 RPA1 NEIL2 MRE11 CENPS-CORT;CORT;CENPS FAAP24 BRIP1 LOC105377022;FANCB FAAP100 PRKDC CHEK1 FANCM CENPX FANCL FANCA REV1 WDR48 FANCC POLD2 FANCE RFC5 PALB2 FANCG RFC2 FANCF RAD51C POLE4 ERCC4 ERCC1 MSH6 MSH2 HMGB1-1 RAP1A USP1 XRCC6 CDK7 ATM CUL4A ATR XRCC5 BRCA1 BRCA2 FANCD2 PMS2 DDB1 FAN1 NBN PARP2 RFC1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH DDB2 GTF2H1 GTF2H3 GTF2H4 FANCI RFC3 ERCC3 MSH3 RFC4 MNAT1 MLH1 RPA2 RAD50 RAD52 RAD51 FEN1 MPG POLK ERCC6 PNKP OGG1 UNG POLB POLD3 RAD23B POLD4 NTHL1 POLD1 POLL POLE MUTYH MBD4 LIG1 PCNA APEX2 XRCC1 NEIL3 POLE2 APEX1 POLE3 TERF2 PARP1 CUL4B RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260211%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex NELFB NELFCD POLR2A NELFA NELFE POLR2L TAF5 ELK1 MED14 MED1 MED23 POLR2D TAF8 MED27 TAF2 GTF2B TAF9 GTF2E2 POLR2B POLR2E POLR2F POLR2G POLR2H POLR2I TAF13 POLR2J;POLR2J2;POLR2J3 TAF7 TAF6 TAF1 ERCC3 MED19 MED16 MED18 MED17 MED12 MED11 MED13 MED10 MED8 MED4 GTF2F1 MED26 MED6 MED29 MED15 MED7 MED22 MED25 MED24 THRA MED21 MED20 GTF2A1 MED28-1 MED30 POLR2M POLR2C TAF10 TAF11 MED31-1 TBP TAF4 CTDP1 TAF3 MED9 TAF12 CCNC-1 CDK8 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260211%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway MAP2K2;MAP2K1 STAT3 RASGRF1 MAPKAPK2 PDPK1 FOS RAP1A ITPR1 GNAO1 CREB1 SRF MAPK1 MAP3K1 ELK4 MAPK3 PIK3CA ELK1 RHOA MAP2K6 HTR1A GNAI1 BRAF MAPK14 MAP2K3 HTR1E HTR1D HTR1B JAK2 HTR1F GNAQ RPS6KA5 HTR2A GNAI3 GNAI2 MAPKAPK3 RASGRP1 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260211%WP4157%HOMO SAPIENS GABA metabolism aka GHB ADHFE1 GLS2 DPEP1 GLS PON3 GAD1 MAOB AKR7A2 ALDH5A1 GAD2 ABAT NAD METABOLISM%WIKIPATHWAYS_20260211%WP3644%HOMO SAPIENS NAD metabolism NT5E NMNAT3 NMNAT2 CD38 NMNAT1 SIRT2 SIRT5 NRK SIRT4 SIRT1 PARP1 SIRT6 NAMPT SIRT3 NADK ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias FGFR1 TGFB2 GLI3 TGFB1 CHST11 BMP6 CDKN1C ADAMTS5 FGFR3 COL10A1 MEF2C TIMP3 BMP7 MMP9 ALPL DDR2 STAT5B RUNX2 PTH SOX6 SOX5 PLAU PTHLH BMPR1A MMP13 ADAMTS1 CTSV;CTSL GHR PTH1R SERPINH1 CALM1 ADAMTS4 FRZB NKX3-2 SCIN MGP SPP1 PRKACA-1 IGF2 SLC38A2 STAT1 VEGFA IFT88 IGF1R HMGCS1-1 HDAC4 AKT1 CAB39 IGF1 THRA COL2A1 IHH PLAT RUNX3 ACAN ENPP1 PTCH1 SOX9 FGF2 FGF18 KIF3A UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260211%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts GPI HK2 UGDH UXS1 GCK PGM3 HK3 GALE GFPT1 PGM1 HK1 VITAMIN D METABOLISM%WIKIPATHWAYS_20260211%WP1531%HOMO SAPIENS Vitamin D metabolism DHCR7 CYP27B1 PTH GC RXRA CYP24A1 VDR RXRB CYP2R1 CYP27A1 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260211%WP5602%HOMO SAPIENS Caffeine in neurons ADRA1D ADORA2A ADRA1B ADRA1A THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260211%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production DUOX2 TSHR TG MAP2K2;MAP2K1 PRKCA SLC26A6 CGA PRKAA2 RAP1B RAP1A CREB1 MAPK1 MAPK3 ELK1 PRKAA1 TRH RAF1 NFKB1 ACY1;ABHD14A-ACY1 DUOX1 TPO ANO1 CLCN5 SLC5A5 PLCD1 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma STAT3 JAK3 NFKB1 IL11 JAK2 IL6R IL11RA IL6 IL6ST ZEB1 SOX4 JAK1 RELA PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260211%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation CYP11A1 PTGS2-2 ANXA2 MITF ANXA5 PTGER4 PTGER2 EDN1 S100A6 PTGER1 PTGER3 HPGDS ABCC4 EDNRB ANXA6 S100A10 PRL PTGFR HPGD AKR1B1 PTGS1 TBXA2R PTGDS ANXA8;ANXA8L1 PPARGC1B PTGDR PTGIR SOX9 PPARGC1A PTGIS PPARG PLA2G4A CBR1-1 PTGFRN HSD11B1 ANXA3 HSD11B2 ANXA1 ANXA4 EDNRA SCGB1A1 TBXAS1 PTGES ZINC HOMEOSTASIS%WIKIPATHWAYS_20260211%WP3529%HOMO SAPIENS Zinc homeostasis SLC39A1 SLC30A3 SLC39A4 SLC30A2 SLC39A3 SLC30A5 SLC30A4 SLC30A1 SLC30A9-1 MT3 MTF1 MT2A SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A8 SLC39A14 SLC39A9 SLC30A10 SLC39A6 SLC39A5 SLC30A7 SLC39A7 SLC30A6 SLC39A2 SLC30A8 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260211%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ACADSB HSD17B10 ACSL3 DECR1 ECI1 ACADL ECHS1 EHHADH-1 ACAA2 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5136%HOMO SAPIENS ALA oxylipin metabolism EPHX2 ALOX15 ALOX5 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260211%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling TSHR MAP2K2;MAP2K1 STAT3 KCNIP3 GNAS-1 PLD1 CGA PDPK1 RAP1A MAP2K3 RAF1 CCNE1 PDE4D-1 MYL12B RBL2 GNA12 GNAQ GNB1 GNAI3 GNAI2 JAK1 CDKN1B SCRIB CCND3 RAP1GAP PIK3R2 PIK3R1 STAT1 RAP1B IGF1R CREB1 GNAO1 MAPK1 AKT1 PIK3CA MAPK3 RPS6 MAP2K6 GNAI1 BRAF MAPK14 ADCY3 RPS6KB1 CDK4 ADCY2 CDK2 RPS6KA1 RALGDS JAK2 APEX1 GNG2 MTOR RB1 HRAS TSHB SRC PLCB1 GNA13 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP4147%HOMO SAPIENS PTF1A related regulatory pathway FGF10 CTNNB1 NOTCH1 KAT2B NKX6-1 PTF1A RBPJL PROX1 PDX1 RBPJ HES1 MALE INFERTILITY%WIKIPATHWAYS_20260211%WP4673%HOMO SAPIENS Male infertility MTHFR SOD3 TCN2 ERCC2 XRCC4 LIG4 MTHFD1 SHMT1 KLK3;KLK2 ARNTL SEPTIN12 SLC46A1 CLU MMP2 CHD2 HLA-DRA CREBBP AGO2 APOB SRD5A2 EP300 XPC TMEM132E BHMT TRIP13 GNAO1 PEMT INSR PEX10 AHR SIRPA;SIRPB1;SIRPG RGS9 XRCC2 LTF DND1 DDX20 FOLH1B;FOLH1 ERCC1 SLC16A7 CCNK IHO1 AR UBR2-2 RAG1 NANOS1 PRDM7;PRDM9 MDM2-2 PRM3 SPATA17 TSSK6 TSSK4 CYP26B1 FAS DDX4 MOV10L1 PUM2 CCNT2-1 PON2 PIWIL2 CRISP2 PON1 TNF EPPIN;EPPIN-WFDC6 PIWIL1 MMP9 PIWIL4 UBD PIWIL3 XRCC3 SPO11 YBX2 HORMAD2 ESR1 HORMAD1 MSMB PRMT6 AHRR PACRG TEX15 USP26;USP29 CXXC1 SOX5 ABLIM1 ATM OR2W3 LRWD1 CYP17A1 CDC42BPA MLH3 CTCFL BRDT MSH4 XRCC5 KDM3A BRCA2 STRA8 FASLG THBS1 PMS2 ESR2 BCL2 UBE2B RFC1 NFE2L2 POLG REC8 NOS1 MLH1 CCNT1 CCNA1 POLB USP8 GPX1 DAZL MSH5 CDK9 CAT NOS2 MTRR NQO1 MTR-1 CYP1A1 ETV5 CLOCK ABCB1 PARP1 NOS3 H4C1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PSAT1 HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260211%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease MAPK14 NR2C2 SMAD4 RUNX2 ANGPT2 SHC1-1 SERPINE1 LTBP1 MAPK8 SMAD2;SMAD3 FBN2 FBN3 ENG LTBP2 CCN2 FBN1 TGFBR1-1 AGTR1 MAPK1 TGFBR3 MAPK3 FLNA POSTN TGFBR2 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260211%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle SDHA CS DLD FH IDH3G OGDH DLST IDH3B ACO2 SDHC SUCLA2 IDH2 SDHD SDHB SUCLG2 SUCLG1 MDH2 IDH3A SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260211%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 FURIN KDR ACE2 NRP1 VEGFA 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260211%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways ACOT8 DHCR7 ACOT7 ACOT11 ACOT12 ACOT13 AMACR ACOT6 SLC27A2 ACOT4 DBP NPC1-1 BAAT CYP7A1 SCP2 ACOT2;ACOT1 EPHX2 ACOT9 SLC27A5 NPC2 HSD11B1 ACOX2 HSD11B2 EBP THEM5 CYP27A1 AGE RAGE PATHWAY%WIKIPATHWAYS_20260211%WP2324%HOMO SAPIENS AGE RAGE pathway PRKCB CYCS-1 NFKBIA PRKCD PRKCA MAP2K2;MAP2K1 STAT3 SHC1-1 MAPK9 MAPK8 SMAD2;SMAD3 IRS1 DDOST CASP8 PRKCZ MMP9 INHBB ALPL HIF1A STAT5A STAT5B MMP7 MMP2 RAF1 JUN NFKB1 MMP14 SP1 MMP13 AGER MSR1 PLA2G4A RAC1 TIRAP IRAK4 MYD88 EGFR MSN EZR STAT1 CASP9 NCF1 CASP3 CHUK INS;INS-IGF2 DIAPH1 MAPK1 AKT1 MAPK3 RHOA INSR FOXO1-1 ROCK1 MAPK14 SOD1 FOXO4 ATF2 NOS2 IKBKB JAK2 CDC42 NOS3 SRC RELA LGALS3 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260211%WP2289%HOMO SAPIENS Drug induction of bile acid pathway ABCC2 CYP7A1 NR1I3 NR1I2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC51A ABCB1 SLC51B NR1H4 ABCC3 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SULT2A1-4 SLC10A1 ABCB11 VDR ABCC4 BAAT LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260211%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance ABCB1 TP53 WNT6 CDKN1A BCL2L1 HIF1A GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2276%HOMO SAPIENS Glial cell differentiation PLP1 CNP MBP MSN GAP43 TPPP MAG 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome UFD1 GP1BA ACTA2 NCOR1 SRF ARNTL NKX2-5 FOXC2 FOXC1 HIRA HIRIP3 CBX5 EMC10 SHH PITX2 FGF10 PAX3 CHRD GBX2 ALDH4A1 PRKN MALT1 PPP1CB OAT HES1 GP9 SERPIND1 FOXA2 GSC2 PAK4 SEPTIN5 SREBF1 DRD2 SHOC2 GLUD1;GLUD2 TBX1 RTN4R RBX1 HAND2 COMT CUL3 CLDN1 CLDN3 RELN FGF8 FGFR1 POLR2A CYP26A1 CYP26B1 PLK1 CDC45 CDH15 FGFR2 RAF1 SREBF2 VWF MAG ASF1A RTN4 TSKS ZDHHC8 ZNF274;ZNF74 RCC1 TANGO2 C22orf39 THAP7 TSSK2 RTL10 NPRL2 NPRL3 TRMT2A ACTC1;ACTG2 ESS2 KLHL22 GP5 RORC BCL2 LZTR1 LRRC74B AIFM3 MRPL40 SCARF2 EGFR TNPO1 DGCR2 SEPTIN11-1 SLC2A4 GP1BB RANGAP1 SLC7A4 GNB1L DEPDC5 CCDC188 ARVCF LOC102724770;DGCR6;DGCR6L RANBP1 SLC25A1 SEPTIN8 DGCR8 P2RX6 DROSHA CRKL SNAP29 CLDN5 MED15 XPO1 ALDH1A2 KPNB1 TXNRD2 PRODH;LOC102724788 CDC42 TP53 RAN H4C1 HDAC3 PI4KA CLTCL1 ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP138%HOMO SAPIENS Androgen receptor signaling NR2C2 PTK2 SIN3A STAT3 PIAS1 PARK7 RACK1 NCOA2 AR CALR-1 SMAD2;SMAD3 NCOA1 MDM2-2 UBE2I NCOR1 TGFB1I1 SIRT1 CTNNB1 TGIF1-1 SMAD4 RUNX2 KAT2B JUN CCNE1 CARM1 UBE3A FHL2 SP1 KDM1A RHOB BUB1B-PAK6;PAK6 PTEN CREBBP BRCA1 NR0B2 RAC1 NCOA3 EP300 EGFR GSK3B SUMO1 PIK3R2 HDAC1 PIK3R1 STUB1 PSMC3IP CREB1 RNF14 EFCAB6 KAT5 PIAS4 PIAS2 RAD9A AKT1 ZNF318 FKBP4 RHOA RNF6 RNF4 BAG1 DAXX FOXO1-1 ROCK1 PATZ1 ROCK2 DSTN NCOA4 TLE5 SMIM40 CAV1 PIAS3 SMARCE1 RB1 CDC42 ETV5 NCOR2 RLN2;RLN1 RAN CCND1 SRC ZMIZ1 PRDX1 FLNA LIMK2 RELA ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260211%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome RCE1 LMNB1 ICMT CFB CFD C3-1 C5 LMNA FNTA LMNB2 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases ADHFE1 L2HGDH ACY1;ABHD14A-ACY1 IDH2 ALDH7A1 D2HGDH GCDH MDH2 APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260211%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein ITGB4 BCL2L12 BCL2 BAX BCL2L14 BCL2L15 PIK3CG BCL2L1 GSK3B PTHLH BCL2L13 BAK1 BID MCL1 BOK GSK3A BCL2A1 BCL2L10 AKT2 MYC AKT3 BCL2L2 ITGA6 AKT1 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260211%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260211%WP550%HOMO SAPIENS Biogenic amine synthesis ASMT AANAT PAH GAD1 PNMT DDC TPH1 TH ACHE MAOA DBH HDC CHAT COMT GAD2 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260211%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming SOX2 EGR1 MYC POU5F1;POU5F1B KLF4 TRIM71 AXON GUIDANCE%WIKIPATHWAYS_20260211%WP5289%HOMO SAPIENS Axon guidance ROBO2 CXCR4 BOC SLIT2 PRKCA PDPK1 FES EFNA1 RRAS ABL1 MET PRKCZ RASA1 SHH NRP1 WNT5A RAF1 MYL12B EPHB1 BMPR2 NGEF GDF7 SEMA3A RHOD L1CAM RAC1 ILK WNT4 CDK5 GSK3B CFL1 TRPC1 PARD3 DCC ROBO1 ENAH CXCL12 RYK-1 FZD3 MAPK1 ARHGEF12 EPHA2 GNAI1 ROCK1 PLXNA1 RGMA PARD6A NTN4 ITGB1 ROBO3 NTN3 SEMA5B DPYSL5 SEMA6C UNC5D SEMA7A EFNB1 ABLIM3 HRAS LRIG2 CDC42 SRGAP2 LRRC4C NCK1 NTNG2 SLIT1 SLIT3 PTCH1 DPYSL2 SRC FYN BMPR1B CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway SMC1A CYP2B6 CYP2A13;CYP2A6;CYP2A7-1 NCOA2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 EHHADH-1 NCOA1 ALAS1 NCOA6 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 DNAJC7 FOXO1-1 ABCC2 NR1I3 HSP90AA1 UGT1A1;UGT1A6 SP1 ABCB1 ABCC3 GSTA3;GSTA5;GSTA1;GSTA2 SULT2A1-4 RXRA PPARGC1A PTPA INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260211%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis IRF9 IFNAR1 PSMB8 PIAS1 TYK2 JAK2 IFNGR2 STAT1 IFNG IRF1 IFIT1 IFNGR1 IFI35 IFIT3 STAT2 SOCS1 JAK1 TAP1 MX1-1 IFNAR2 IFITM3;IFITM2;IFITM1 PTPN2 OAS1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260211%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 CUX1 LRIG1 FOSB GSDMA KLK13 GLI2 KRTAP8-1 KLK14 FOXN1 BMP6 KRT19 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 LGR5 MSX2 CD200 CCN2 NOTCH2 CTNNB1 CASP14 SOX2 NOTCH1 SMAD1 LHX2 SOSTDC1 BMP4 SFRP1 PROM1 WNT5A GPRC5D SMAD4 CD34 ADAM17 PERP JUN MSX1 NFKB1 LEF1 BMPR1A TCF4 KRT15 FOXE1 NR3C1 BCL11B DKK1 GTPBP4 DKK4 GJB6 FST EGR2 ELANE GATA3 EGFR IFNG FOS TP63 NFATC1 FZD1 DKK3 WIF1 ZBTB16 IGF1 FOXQ1 DSC2 GAS1 RBPJ RUNX3 HR S100A4 HOXC12 SOX9 PHLDA1 SPINK6 KITLG SPINK5 KRTAP3-2;KRTAP3-3-1 ADAMTS20 DSG1 KLK6 DSG4 DLX3 KLK5 IGFBP5 KLK4 KLK7 ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260211%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway GCLC NFKBIA GCLM NFE2L2 IKBKG GUCY1A2 TMPRSS2 IL12A ACE2 IRF3 GUCY1B1 CHUK PRKG2 SLC7A11 IL1B CXCL8 TNF CCL13;CCL2 MMP3 NOX1 NFKB1 IKBKB NQO1 IL6 GSTA3;GSTA5;GSTA1;GSTA2 RXRA HMOX1 KEAP1 MMP1 GUCY1A1 RELA GLUCURONIDATION%WIKIPATHWAYS_20260211%WP698%HOMO SAPIENS Glucuronidation UGDH UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PGM3 UGT2A1 PGM2 PGM5 UGT1A1;UGT1A6 PGM1 HK1 UGP2 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260211%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport ST20-MTHFS;MTHFS SLC46A1 MTHFR QDPR DHFR2;DHFR MTHFD2L ALDH1L2 FOLR1 MTR-1 ALDH1L1 FTCD ATIC MTHFD1 SHMT1 MTHFD2 TYMS GART SHMT2 SLC19A1 IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260211%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis GLRX5 HSCB NARF NFU1 ABCB7 NUBP1 ISCU NUBP2 NFS1 LYRM4 FDX1 FDXR CIAO2B FXN HSPA9 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260211%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease EGF BDNF CASP7 MAP2K2;MAP2K1 EGFR RAF1 NTRK2 HRAS CASP3 HTT RPS6KA5 CREB1 MAPK1 GRM1 MAPK3 ELK1 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260211%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells NRAS STAT3 IL6R IFNGR2 EPOR STAT1 IFNG RPTOR IFNGR1 FOXM1 MLST8 CCND2 AKT2 AKT3 AKT1 STAT5A STAT5B CDK4 PRL KRAS AKT1S1 JAK2 MTOR IL6 CISH HRAS PRLR GHR SOCS2 SOCS3 EPO SOCS1 CCND3 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260211%WP5050%HOMO SAPIENS TCA cycle in senescence FH TP53 PDP2 ME1 ME2 GOT1-1 PDHA1 MDH1 BRAF PDK1 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2879%HOMO SAPIENS Farnesoid X receptor pathway CYP7A1 FKBP5 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IP6K3 NR1H4 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP8B1 ABCB4 SULT2A1-4 SLC27A5 SLC10A1 RXRA PPARGC1A IRS2 ABCB11 NR0B2 FGF19 SLCO2B1 BAAT NEUROINFLAMMATION%WIKIPATHWAYS_20260211%WP4919%HOMO SAPIENS Neuroinflammation MAPK14 NFKBIA CHUK TLR4 JUN NOS2 ASCC1 MAPK8 MTOR RELA FOS FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260211%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses CYP2E1 ADH5 CEBPB MTHFR CREB1 ALDH1A1 CBS;CBSL MTR-1 ALDH1L1 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260211%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups PYCR1 ODC1 ASS1 GLUD1;GLUD2 SMS ASL CPS1 NAGS OAT SARDH SRM ALDH18A1 ACY1;ABHD14A-ACY1 OTC GATM GAMT CKM ARG2 PYCR3 CKB ARG1 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260211%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease TGFB1 CASP7 MAPK9 MAPK8 PPARA NDUFA4L2 SDHC SDHD CASP8 SDHB COX6B2 PIK3R3 COX7B2 MLX COX8C MLXIP CCL13;CCL2 NR1H3 SDHA COX7C NDUFS8 NDUFS3 COX5A MAP3K11 NDUFB11 NDUFA9 NDUFA4 SREBF1 DDIT3 CEBPA IL6R PIK3R2 PIK3R1 PRKAA2 INS;INS-IGF2 AKT2 AKT3 XBP1 AKT1 INSR EIF2AK3 PRKAA1 SMAD7 BAX VCAM1 IKBKB LEP IL1A SOCS3 RELA CYCS-1 UQCRB UQCR11 UQCR10 BID UQCRQ UQCRC1 UQCRFS1 CYC1 FAS UQCRC2 ATF4 IRS1 IRS2 TNF BCL2L11 ADIPOQ MAP3K5 NDUFV1 ERN1 JUN PKLR NFKB1 IL6 GSK3A NR1H4 RXRA FASLG RAC1 NDUFA11 NDUFA12 NDUFA10 COX6A2 BBC3 NDUFC1 NDUFS7 NDUFS6 NDUFS4 EIF2S1 NDUFS2 NDUFS1 NDUFB9 NDUFB8 GSK3B PRKAG1 NDUFB7 PRKAG2 COX7A2L-1 NDUFB10 PIK3CD NDUFB6 BAK1 PIK3CB NDUFB5 PRKAG3 NDUFB4 NDUFB3 CASP3 COX4I2 COX6A1 NDUFB2 LEPR NDUFB1 TRAF2 PRKAB2 COX7A2 IL1B COX6B1 NDUFA13 CXCL8 PRKAB1 TNFRSF1A NDUFC2;NDUFC2-KCTD14 PIK3CA ADIPOR1 NDUFV3 NDUFV2 COX7B ADIPOR2 COX4I1 NDUFA8 NDUFA7 NDUFA6 COX8A NDUFA5 NDUFA3 NDUFAB1 CDC42 NDUFS5-1 CYP2E1 COX5B COX6C ITCH SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260211%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway HSD3B1;HSD3B2 SLCO4A1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLCO1A2 HSD17B3 HSD17B1 SLCO2B1 HSD17B2 ESR2 SLCO4C1 ESR1 CYP19A1 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism FUT1 B3GALT2 B3GALT1 FUT2 FUT6;FUT5;FUT3 B3GNT5 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260211%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin CXCR4 MADCAM1 BCL2 IL2RG ANGPT2 PGR GATA2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E ANGPT1 MCL1 CXCL11 IFNG SELL IL10 VEGFA CXCL12 PIBF1 IL4 CXCL8 TNF MAPK3 CXCL10 CCL3L1;CCL3L3;CCL3;CCL18 CCL13;CCL2 MRC1 STAT5A STAT5B GAB3 CXCR3 VCAM1 IL3 JAK3 MAP2K4 CD69 CX3CL1 CCL5 MAPK11 IL2RB ITGA4 IL6 IL15 NCR1-1 NR3C1 CCL4L2;CCL4L1;CCL4 JAK1 CCL8 ESR2 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260211%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism FMO3 SLC44A1 CHDH ALDH7A1 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260211%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 TGFB1 ITGB1 CDH1 CLDN4 CCND1 NRG3 MYC TNF ITGA6 TERT AKT1 ERBB4 ALPL ZEB2 SFRP1 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260211%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IRAK4 NFKBIA TAB2 TBK1 MYD88 IKBKG IRF3 CHUK IRAK3 IFNB1-4 CXCL8 TNF TRAF3 IRF7 TRAF6 TRAM1 INPP5D TLR4 NFKB1 TAB1 IKBKB IL6 MAP3K7 TIRAP RIPK1 TICAM1 IRAK1 IKBKE MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260211%WP2006%HOMO SAPIENS miR targeted genes in squamous cell VEZT SRPRB-1 PWP1 ANPEP ATP6V0E2;ATP6V0E1 DHX57 ARFIP1 AP2A1 CIAO2A PISD DHX40 COMMD9 TUBA1A RARS1 ANP32B NRP1 TRAM1 HOXA7 MAGT1 TMED7 NF2 HES1 PRPF40A FBXW11 UBE2J1 CSDE1 POM121;POM121C PTMA MRPS33 AKAP8 IDH1 MPZL1 AP3D1 SPCS3 GFPT1 NEDD4 ACAA2 P4HA2 GOLGA7-1 RAI14 TMED10 SDCBP TMEM59 GAS2L1 PEDS1-UBE2V1;PEDS1 PKM VCAM1 TBCA RHEB CHMP2A PICALM ADAR FNDC3B FNDC3A TMED2-1 CTDSP1 MRPL20 PNP-1 POLD2 HNRNPM MOV10 PDLIM7 GALNT7 GALNT1 FMNL2 MRC2 TMEM43 SH3BGRL3 SPTLC1 ANXA2 ELOVL5 LAMC1 PXDN MET SMAD1 PPP1R7 ARCN1 AXL LAMTOR5 ARF4-1 RTN4 POGLUT3 THBS1 GNAI2 TPM3 TPM1 TGFBR2 RAB34 PODXL SRSF9 ATP2A2 CBFB YWHAQ SLC38A2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SLC4A10 NCL-1 GYS1 SYNE2 ATRX SIGMAR1 SLC38A1 ADIPOR2 MTPN SEC23A HSD17B12 DNAJB1 POLR2C SH3BP4 E2F3 MAP3K8 SLC12A2 HMOX1 FGF2 PDCD4 CUL4B ATP6V1C1 TXNRD1 BET1 CPNE8 ATP6V1F MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway MECR OXSM MCAT HSD17B12 ACACA FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260211%WP206%HOMO SAPIENS Fatty acid omega oxidation CYP2D6;LOC107987479;LOC107987478-1 CYP2E1 ADH4 ALDH1A1 CYP2A13;CYP2A6;CYP2A7-1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH1C;ADH1B;ADH1A ALDH2 CYP1A1 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260211%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RARA RXRA RARB RARG RXRB RXRG DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260211%WP5053%HOMO SAPIENS Development of ureteric derived collecting system GDF11 HOXD11 TGFB2 GLI3 HOXA11 TGFB1 FST GLI2 ETV4 PAX2 RET GFRA1 GRIP1 RARB SMAD1 BMP7 MYCN ANOS1-1 BMP4 SHH SALL1 SIX2 SIX1 DCN RARA BMPER WNT11 GPC3 CRIM1 SPRY1 CTDNEP1 FRAS1 GLI1 EYA1 VANGL2 BMPR1A FREM1 GDNF FREM2 BMPR2 ETV5 CELSR1 CCND1 BMP2 ITGA8 RARG BMP5 SMO HEME BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP561%HOMO SAPIENS Heme biosynthesis CPOX ALAD ALAS2 FECH UROD UROS HMBS PPOX ALAS1 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260211%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex SMARCA4 SMAD4 BCL2 ATM BCL2L1 GZMH;GZMB-1 GABPB1 GABPA MCL1 ETV6 ZFX TERF2 CREBBP PTEN DNMT1 FOXO3 DNMT3B DNMT3A FLT3 EP300 PURINE METABOLISM%WIKIPATHWAYS_20260211%WP4792%HOMO SAPIENS Purine metabolism HPRT1 ADA XDH PRPS1 ADSL AMPD1 APRT ATIC IMPDH1 DGUOK ADSS2 ITPA PNP-1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260211%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO2 FMO3 FMO4 FMO5 FMO1 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling PTK2 MAP2K2;MAP2K1 STAT3 GAB1 PAK1 PTGS2-2 MAPK8 MAP4K1 GRB2 HGF FOS SOS1 RAP1B RAP1A PXN ITGA1 MET MAPK1 RASA1 CRKL MAPK3 PIK3CA ELK1 CRK RAPGEF1 ITGB1 PTK2B JUN RAF1 HRAS PTEN SRC DOCK1 PTPN11 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260211%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis IRAK4 NFKBIA REL RELB ELANE TAB2 MYD88 IKBKG NFKB2 MAPK8 LCN2 IRF1 IL10 TLR8 CHUK CXCL8 TNF TRAF3 TLR7 IRF7 TRAF6 CCL3L1;CCL3L3;CCL3;CCL18 MAPK14 IRF5 TLR4 VCAM1 NFKB1 TAB1 IKBKB GZMH;GZMB-1 IL6 ICAM1 IL1A MAP3K7 CCL4L2;CCL4L1;CCL4 IRAK1 RELA AUTOPHAGY%WIKIPATHWAYS_20260211%WP4923%HOMO SAPIENS Autophagy ULK1 PRKAG1 PIK3R4 PRKAG2 PRKAA2 PRKAG3 RPTOR RB1CC1 DEPTOR MLST8 PRKAB2 WIPI2 ATG3 PRKAB1 PIK3C3 PRKAA1 ATG9A MAP1LC3B2;MAP1LC3B-1 BECN1 ATG12-1 AMBRA1 ATG16L1 AKT1S1 MTOR ATG101 ATG7 ATG5 UVRAG ATG14 ATG13 PURINERGIC SIGNALING%WIKIPATHWAYS_20260211%WP4900%HOMO SAPIENS Purinergic signaling GNAZ P2RY12 GNAS-1 P2RY10 ADORA2B P2RY14 P2RY6 PANX1 P2RY4 P2RY2 GNAO1 P2RX6 ADORA2A GNAI1 LPAR4 GNA11 LPAR6 P2RY13 P2RY11 P2RY8 GNAT2 P2RY1 ADORA1 GNAT3 GNAT1 P2RX7 GNAI3 P2RX5 P2RX4 P2RX3 P2RX2 GNAI2 P2RX1 ADORA3 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260211%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions CCR6 TGFB2 TGFB1 STAT3 NFKB2 SMAD2;SMAD3 CASP1 STAT5A STAT5B TYK2 FAM20C IKZF2 CCN3 CCR8 NKX6-2 MCAM TMEM119 CD86 SEMA3F CCL1 KLRG1 CD80 P2RY12 IL12A IFNG PDGFA CD28 TGFBR1-1 IGF1R CD274 PDCD1 GALC FOXO1-1 IGF1 TLR4 IL18 TNFRSF1B CD47 OSM SOX9 SIRPA;SIRPB1;SIRPG SOCS3 CX3CR1 PTK2 IL10RA IL10RB CD4 PDGFRA ITGB3 SSTR2 NKX6-1 AREG NLRP3 TNF CXCL2;CXCL3;CXCL1-1 CTLA4 MMP9 ITGA2 EBI3 HEXB CSPG4 CNP MBP CD44 NKX2-2 NFKB1 ITGAV MOG IL6 OLIG1 OLIG2 IL33 CCL20 PLP1 RAC1 LGALS1 JAK1 CD68 IL1RAP TGFBR2 SPP1 MYD88 IL2RG EGFR STAT4 IL12RB1 STAT1 IL12RB2 IL10 VEGFA CXCL12 FOXP3 IL2 IL4 IL1B AIF1 TGFBR3 GSDMD MAPK14 FOXO4 JAK3 HTR7 NOS2 IL2RA IL2RB CDC42 TGM2 FOXO3 ROS1 APOD LGALS3 RETT SYNDROME%WIKIPATHWAYS_20260211%WP4312%HOMO SAPIENS Rett syndrome KDM5B TRRAP FOXG1 GPS2 SYNGAP1 RHOBTB2 CECR2 HIVEP2 SMC1A EIF2B2 KCNJ10 TBL1XR1 IMPDH2 HDAC1 GABBR2 GRIN2A SMARCA2 NCOR1 SRRM3 MEF2C GNAO1 SYNE2 CHD4 HDAC5 XAB2 HDAC8 BRAF CRK GABRD STXBP1 SMARCA4 GRIN2B GABRA3 SCN1A SHANK3 SCN2A CDKL5 ACTL6B NCOR2 HTT TCF4 SCN8A TAF1B HAP1 SATB2 MECP2 SMARCA1 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2406%HOMO SAPIENS Cardiac progenitor differentiation CXCR4 ANPEP TGFB1 NOG KDR PDGFRA MYL2 NRG1 ISL1 GATA4 SOX2 MEF2C NOTCH1 ZFP42 NKX2-5 MIXL1 BMP4 BMP1 LIN28B MESP2 PAX6 TBXT FOXA2 MYLK3 DKK1 ACTC1;ACTG2 LIN28A WNT3A INHBA GSK3B IGF2 MESP1 TBX20 THY1 IRX4 TBX5 INS;INS-IGF2 SOX17 SOX1 MYH6 IGF1 MAPK14 ROR2 KIT NANOG;NANOGP8 POU5F1;POU5F1B SIRPA;SIRPB1;SIRPG NCAM1 TNNI3 NODAL FGF2 TNNT2 SCN5A BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260211%WP272%HOMO SAPIENS Blood clotting cascade F10 F12 PLAU F11 SERPINF2 SERPINE1 F3 VWF PLAT F5 F8 F9 SERPINB2 KLKB1 FGB FGA F13B KLK1 FGG F2 F7 PLG WNT SIGNALING%WIKIPATHWAYS_20260211%WP428%HOMO SAPIENS Wnt signaling MAPK9 MAPK8 CTBP2 CCND2 NKD1 NKD2 CTBP1 SOST SFRP1 PLAU LEF1 TCF7 VANGL2 TCF7L2 TCF7L1 FZD10 FRAT2 CSNK2A2 DKK1 DKK2 DKK4 SFRP4 CSNK2B DAAM2 PRICKLE2 GPC4 PPP3R1 FZD1 RYK-1 WNT10B MYC ROR1 WNT10A FZD3 FZD2 INVS FZD5 FZD7 RHOA FZD6 WIF1 FZD9 ROCK2 FZD8 PPP3CA PPP3CB PPP3CC SERPINF1 CCND1 PLCB4 CTNNBIP1 KREMEN1 SENP2 PRKCG SFRP5 CSNK2A1;CSNK2A3 PLCB1 PLCB2 CXXC4 PORCN PRKCB NOTUM PRKCA CSNK1A1 WNT7B WNT7A CHD8 CTNNB1 WNT5B WNT5A FOSL1 JUN WNT6 PRICKLE1 DVL1 RAC1 DVL2 DVL3 SFRP2 WNT1 CCND3 WNT2 WNT3 WNT4 WNT3A TPTEP2-CSNK1E;CSNK1E GSK3B WNT2B NFATC1 SOX17 VANGL1 AXIN1 PLCB3 CER1 WNT16 CAMK2B CAMK2D NFATC3 NFATC2 CAMK2A LRP5 NFATC4 ROR2 NLK LRP6 WNT11 DAAM1 APC CAMK2G MAP3K7 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP2D6;LOC107987479;LOC107987478-1 PPAR SIGNALING%WIKIPATHWAYS_20260211%WP3942%HOMO SAPIENS PPAR signaling ACAA1-1 FABP3 FABP4 EHHADH-1 PDPK1 GK PPARA CPT2 HMGCS2 ME1 CPT1C SLC27A4 RXRB SORBS1 CD36 RXRG APOC3 UBB;UBC ADIPOQ SCD CYP7A1 NR1H3 ACSL1 APOA5 ANGPTL4 SCP2 LPL OLR1 FADS2 APOA2 CYP8B1 APOA1 FABP1 SLC27A5 RXRA LOC100509620;LOC112267859;AQP7 PPARG PCK1 SLC27A1 ILK ACOX1 PCK2 MMP1 PLIN1 PLTP PPARD UCP1 CYP27A1 ERBB SIGNALING%WIKIPATHWAYS_20260211%WP673%HOMO SAPIENS ErbB signaling PRKCB PTK2 NRAS PRKCA MAP2K2;MAP2K1 SHC1-1 GAB1 MAPK10 MAPK9 MAPK8 MDM2-2 PDPK1 GRB2 SOS1 NRG1 NRG2 ABL1 AREG SOS2 SHC4 SHC2 SHC3 PIK3R3 ELK1 TGFA BCL2L11 ERBB3 PAK2 STAT5A STAT5B EGF PLCG2 RPS6KB2 MAP2K4 HBEGF RAF1 JUN BUB1B-PAK6;PAK6 ARAF ERBB4 PAK3 CDKN1B PAK5 PAK4 MAP2K7 EGFR GSK3B PAK1 PIK3CD PIK3R2 PIK3R1 PIK3CB NRG4 CDKN1A AKT2 MYC AKT3 CAMK2B MAPK1 AKT1 EREG CRKL BTC PIK3CA MAPK3 CAMK2D ABL2 CRK BRAF FOXO1-1 CAMK2A RPS6KB1 KRAS BAD MTOR HRAS CBLB NCK2 NCK1 TP53 CAMK2G CCND1 NRG3 SRC PRKCG CBL ERBB2 EIF4EBP1 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260211%WP383%HOMO SAPIENS Striated muscle contraction pathway ACTA2 MYL4 TTN-1 MYL2 TNNI1 MYOM1 DMD MYBPC3 MYBPC1 MYBPC2 ACTA1 TCAP MYH6 NEB ACTN3 TMOD1 DES MYL1 VIM TNNC1 ACTG1 ACTN2 TNNI2 TNNI3 TNNC2 TPM4 TPM3 ACTN4 TPM2 MYH3 TPM1 TNNT1 TNNT2 TNNT3 ACTC1;ACTG2 MYL3 MYH8 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260211%WP4742%HOMO SAPIENS Ketogenesis and ketolysis SLC2A1 BDH1 OXCT1-1 CPT2 SLC16A1 SLC25A20 UCP2 ACAT1 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5393%HOMO SAPIENS Androgen biosynthesis HSD3B1;HSD3B2 CYP17A1 POR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HSD17B2 CYP11B1;CYP11B2 SULT2A1-4 HSD17B3 HSD17B4 HSD11B1 HSD17B1 HSD11B2 SRD5A2 SRD5A1 AKR1D1 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260211%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology LBR TGFB2 NRAS TGFB1 TGFB3 MAP2K2;MAP2K1 CFL1 ADCY9 SMAD2;SMAD3 TMEM43 GRB2 CCN2 SOS1 SYNE4 SYNE3 SYNE2 SUN1 SRF SYNE1 SOS2 PLEC MAPK1 MAPK3 KIF5B RHOA WWTR1 EMD BANF1 SMAD4 ADCY4 MAP3K9 TMPO ADCY3 ADCY10 ADCY2 ADCY1 LEMD3 KRAS ADCY8 ADCY7 ADCY6 ADCY5 HRAS PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260211%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response PPP1R15A DNAJB11 DDIT3 ASNS EIF2A WARS1 NFE2L2 ATF6 HSP90B1 CALR-1 ATF3 ATF4 NARS1 EDEM1-1 XBP1 DNAJC3-1 ERP27 BCL2L11 EIF2AK3 PDIA6 ERN1 UBE2E1 DNAJB9 HSPA5 TRIB3 BBC3 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5103%HOMO SAPIENS Progeria associated lipodystrophy LMNB1 POLD1 SMAD4 BANF1 TGFB1 WRN FFAR3;GPR42 KCNJ6 ZMPSTE24 SMAD2;SMAD3 RECQL LMNA LMNB2 FBN1 ICMT PARP1 INS;INS-IGF2 PPARG MUCL3 SPRTN FNTA NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260211%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection CYCS-1 NFKBIA BCL2 GUCY1A2 NOS1 CASP9 IFNG GRIN2A XIAP GRIN1 GUCY1B1 PRKG2 CREB1 IL1B CAMK2B TNF CNGB1 CAMK2D AKAP9-1 PDE3A CNGA2 CNGA3 CNGA4 CNGB3 CAMK2A GRIN2C PDE2A GRIN2B DLG4 GRIN2D PPID NOS2 NFKB1 BAD NPPB TSPO NEFL ACTN2 CAMK2G NOS3 CALM1 GUCY1A1 NPR1 RELA NPPA CNGA1 AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260211%WP5526%HOMO SAPIENS Age related macular degeneration PARP2 RPS6KB1 PRKAG1 PRKAG2 MTOR PRKAA2 PRKAG3 PMAIP1 RPTOR SIRT1 MLST8 PRKAB2 PPARGC1A PRKAB1 MAPK3 PRKAA1 MDH1 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260211%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells TGFB1 ACTA2 MCU TRPV5 NOS1 BAK1 FFAR3;GPR42 SMAD2;SMAD3 CASP9 PPP3R1 TGFBR1-1 CASP3 APAF1 CALCA CASP8 MAPK1 AKT1 TNFRSF1A PDE1B PIK3CA G3BP1 BRAF MAP3K5 SMAD4 CRYZL2P-SEC16B;SEC16B RGN BAX PTH RAF1 TNFSF11 MTOR FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260211%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins CYCS-1 BCL2 CASP7 DFFB PAK1 DFFA MAPK8 CASP9 MAPKAPK2 CASP3 FADD FAS FAF1 APAF1 ACTA1 HSPB1 TNF CASP8 MAP3K1 RIPK2 DAXX PAK2 LMNB1 NFX1 MAP2K4 SMIM40 JUN RB1 LMNA LMNB2 ACTB-1 ACTG1 PARP1 IL1A ARHGDIB CASP10 PRKDC FASLG SPTAN1 MAP3K7 MAPKAPK3 CFLAR CASP6 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260211%WP4963%HOMO SAPIENS p53 transcriptional gene network CDC25A ADORA2B SESN2 MSH2 FAS NOTCH1 TP53I3 TNF GADD45A IRF5 CCL13;CCL2 E2F7 TIGAR GLS2 ZMAT3 SFN PERP ISG15 CX3CL1 CCNE1 ALDH4A1 LIF XRCC5 PTEN FASLG THBS1 POLH BBC3 PIDD1 SESN1 IRF9 ULK2 XPC MGMT ULK1 ERCC5;BIVM-ERCC5 CDC25C DDB2 AURKA PRKAG1 PRKAG2 RRM2B TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FUCA1 PRKAA2 PRKAG3 PMAIP1 PML RPTOR DEPTOR MLH1 SLC2A1 MLST8 APAF1 TRAF4 CCNG1 CDKN1A SLC7A11 PRKAB2 SAT1 POLK CPT1C PRKAB1 DDIT4 PRKAA1 NCF2 GPX1 BAX ACAD11 CDK2 SERPINB5 SCO2 AKT1S1 PCNA ADGRB1 ULBP1-2 DRAM1 BTG2 RPRM SERPINE1 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L MTOR SIVA1 TP53INP1 ICAM1 NANOG;NANOGP8 TSC2 FANCC METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders CTH MAT2B AHCY MAT1A CSAD CBS;CBSL BHMT CDO1 GNMT ADK MTR-1 BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation DCN WNT4 SST CTNNB1 BMP2 LEFTY2;LEFTY1 SMAD1 SMAD5 DKK1 SMAD9 BCL2L11 FOXO1-1 SFRP1 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260211%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade CD80 PTPN6 PPP2CB;PPP2CA PIK3CD PIK3R2 PIK3R1 PIK3CB CD28 CTLA4 PIK3R3 PIK3CA CD86 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PTPN11 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260211%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT6 CARM1 NOS2 DDAH1 NOS1 PRMT8 PRMT7 PRMT3 DDAH2 PRMT2 NOS3 PRMT1 PRMT5 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260211%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells RAB5C NRAS KRAS RAF1 RAB5A HRAS RAB5B RRAS2 PDCD6IP RRAS MRAS RAB27A ARAF MAPK1 MAPK3 BRAF HNRNPH1 HGS IL11 SIGNALING%WIKIPATHWAYS_20260211%WP2332%HOMO SAPIENS IL11 signaling BCL2 TGFB1 MAP2K2;MAP2K1 STAT3 PIAS1 IL11 PIK3R2 PIK3R1 IL11RA YES1 STAT1 PDPK1 FES GRB2 CHUK IL6ST CREB1 IBSP MAPK1 AKT1 MAPK3 ITGA2 RPS6 RUNX2 RPS6KB1 ATF1 RPS6KA1 RAF1 TYK2 IKBKB JAK2 PIAS3 BIRC5 HRAS ICAM1 SRC SOCS3 JAK1 FYN RELA PTPA PTPN11 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome ASTL NEURL3 KANSL3 PLXNB2 SNRNP200 MMS19 DUSP2 CIAO2A ANKRD23 CIAO2B MAPK1 MAPK3 RHOA COX11 ZP2 ADRA2B COL2A1 ANKRD39 LMAN2L NCAPH PARL CIAO1 FAM178B ITPRIPL1 TMEM127 ERBB2 CNNM3 CNNM4 FER1L5 STARD7 SEMA4C IL5 SIGNALING%WIKIPATHWAYS_20260211%WP127%HOMO SAPIENS IL5 signaling MAP2K2;MAP2K1 STAT3 SHC1-1 GSK3B PIK3R2 PIK3R1 STAT1 GRB2 SOS1 IL2 MAPK1 IL5RA AKT1 MAPK3 ELK1 RPS6 SYK STAT5A CSF2RB STAT5B BTK LYN RPS6KB1 RPS6KB2 KRAS PIK3CG RPS6KA1 JUN RAF1 JAK2 GSK3A SPRED1 FOXO3 JAK1 MAPT PTPN11 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260211%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway DUOX2 NFKBIA NOD2 CASP7 NOD1 NLRC4 IKBKG MEFV NLRP4 AAMP CARD9 CARD6 ACAP1 CASP9 AIM2 NLRP10 NAIP SUGT1 XIAP NLRP1 CHUK IL1B NDUFA13 NLRP3 CASP8 NLRP7;NLRP2 RIPK2 COPS6 CASP1 PYCARD PRDM1 IKBKB HSP90AA1 IL18 ERBIN NLRP12 CASP5;CASP4 RAC1 RELA LEPTIN SIGNALING%WIKIPATHWAYS_20260211%WP2034%HOMO SAPIENS Leptin signaling PTK2 PDE3B MAP2K2;MAP2K1 STAT3 SHC1-1 MAPK8 NCOA1 GRB2 SOS1 KPNA4-1 IRS1 ELK1 ESR1 EIF4E STAT5B PLCG2 PLCG1 RAF1 NFKB1 SP1 GSK3A ACACA KHDRBS1 PTEN RAC1 JAK1 SOCS7 REL CFL2 IKBKG GSK3B PIK3R2 PIK3R1 PRKAA2 STAT1 CHUK LEPR CREB1 MAPK1 AKT1 MAPK3 RHOA RPS6 PRKAA1 FOXO1-1 ROCK1 ROCK2 ACACB MAPK14 RPS6KB1 RPS6KA1 IKBKB JAK2 BAD MTOR LEP CISH HRAS CDC42 NOS3 SRC SOCS2 SH2B1 SOCS3 ERBB2 EIF4EBP1 FYN RELA PTPN1 PTPN11 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260211%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein IFT81 IFT27 WDR19 DYNC1I1 IFT140 DYNC2H1 IFT122 IFT80 HSPB11 WDR35 DYNLT1 DYNLRB2 DYNC1I2 DYNLRB1 IFT43 IFT46 DYNLT2B DYNC1LI1 DYNC1H1 DYNC2I2 DYNC2I1 DYNC2LI1 IFT22 DYNC1LI2 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260211%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY4 ADCY3 ADCY10 ADCY2 ADRB1 ADCY1 ADRA2C ADCY8 ADRA2B ADCY7 ADRA2A ADCY6 ADCY5 ADCY9 ADRA1D ADRB2 PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260211%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA ACAA1-1 SCP2 HSD17B4 ACOX1 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260211%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity CYP2B6 CYP2C9;CYP2C19 CYP26A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCD2 PPARA RARB ABCD3 ABCG5 CYP7A1 ABCC2 NR1H3 RARA NR1I3 NR1I2 CYP4B1 ABCG1 ABCB1 NR1H4 CYP2E1 CYP27B1 ABCC3 CYP8B1 ABCB4 PPARG ABCB11 CYP24A1 VDR CYP1A2 RARG PPARD ABCA1 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260211%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway CUL3 SLC11A2 NFE2L2 PDHB EGLN1 PRKAG1 ACACA VEGFA SLC2A1 TP53 LDHA KEAP1 PRKAB1 PDHA1 RPS6 HIF1A PRKAA1 PDK1 ACACB GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis CYP11B1;CYP11B2 CBR1-1 HSD11B1 HSD11B2 SRD5A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP21A2 SRD5A1 AKR1D1 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP5171%HOMO SAPIENS Leukotriene metabolic pathway DPEP2 LTA4H DPEP1 ALOX5AP DECR2 PTGR1-1 ABCC1 GGT1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 DECR1 GGT5 LTC4S ALOX5 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation NUDC NDEL1 PAFAH1B3 VLDLR PAFAH1B1 CLIP1 TUBA1A PAFAH1B2 DYNC1H1 DCX RELN SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260211%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP CDC23 H3-3A STAT3 H2BC21 ANAPC7 ANAPC4 ANAPC5 ANAPC2 ANAPC10 ANAPC11 CDC26 ANAPC15 ANAPC16 CDC16 RPS27A UBB;UBC CDKN2A FZR1 RPS6KA3 IGFBP7 JUN NFKB1 IL6 CDKN2D CDC27 CDKN2B CDKN2C UBE2E1 CDKN1B UBE2D1 H2AC4 ANAPC1 CEBPB FOS UBE2C CCNA2-1 CDKN1A CXCL8 MAPK1 MAPK3 CCNA1 EHMT2 EHMT1 MAPK7 CDK4 CDK2 RPS6KA1 RPS6KA2 UBE2S H2BC5 H2BC1 H4-16 H2AZ2;H2AZ1 UBA52 CDK6 H2AJ H2BC15;H2BC3;H2BC11;H2BC12 H2AC14 IL1A H2AC20 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H4C1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AB2;H2AB3;H2AB1 H4C6 RELA NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260211%WP3645%HOMO SAPIENS NAD biosynthetic pathways PARP2 IDO1 CD38 NADSYN1 NMNAT1 SIRT2 PARP4 NAPRT SIRT5 SIRT4 SIRT1 PARP1 SIRT6 TDO2 NAMPT TNKS2 TNKS SIRT3 BST1 QPRT ACMSD GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260211%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HEXA IDS HPSE GUSB ARSB NAGLU GLB1 HGSNAT HPSE2 IDUA GNS SGSH GALNS HYAL1 HYAL2 HEXB HYAL4 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260211%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260211%WP129%HOMO SAPIENS Matrix metalloproteinases TIMP2 TNF TIMP3 MMP9 MMP21 MMP20 MMP25 MMP24 MMP27 MMP28 MMP7 TCF20 MMP2 MMP3 MMP8 MMP10 MMP12 MMP11 MMP14 MMP13 MMP16 TIMP1 MMP15 MMP23B TIMP4 MMP17 MMP19 MMP1 BSG CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260211%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism TGFB1 BMP6 VCP-1 BHLHE41 HMGB1-1 CALCA CSF1 NOTCH1 ARNTL SMAD1 SMAD5 SP7 SOST BMP4 CTSK WNT5A SMAD4 RUNX2 PTH PER1 CHRD ARHGAP4 FYCO1 EFNB2 ATG4C DRAM2 SEMA4D CTF1 TNFRSF11B IL6 RORB BMPR2 TRAP1 SEMA3A PLEKHM1 BMP3 BMP2 ATG101 CTHRC1 BMP5 DKK1 ATG10 ATG13 TNFRSF11A NPAS2 BCL2 ULK1 PRKAA2 BHLHE40 RB1CC1 LAMP2 NFATC1 WNT10B ATG3 MAP1LC3A WNT16 AKT1 CRY1 PIK3C3 TRAF6 MAP1LC3B2;MAP1LC3B-1 MEPE BECN1 IGF1 ATG12-1 LRP5 AMBRA1 IL3 ATG16L1 JAK2 TNFSF11 MTOR LEP SQSTM1 SERPINF1 CLOCK ATG7 ATG5 NR1D2 SMAD9 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260211%WP259%HOMO SAPIENS Nifedipine activity SOD1 PTK2B MAP2K2;MAP2K1 PCNA MAPK1 KDR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BDKRB2 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2876%HOMO SAPIENS Pregnane X receptor pathway PSMC5 CYP2B6 CYP2A13;CYP2A6;CYP2A7-1 NCOA2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NCOA1 ABCC4 DNAJC7 FOXO1-1 ABCC2 NRIP1 NR1I2 SRPX2 HSP90AA1 UGT1A1;UGT1A6 ABCB1 ABCC3 GSTA3;GSTA5;GSTA1;GSTA2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SRC SULT2A1-4 RXRA PPARGC1A CYP4F3;CYP4F2;CYP4F12;CYP4F11 NCOA3 G PROTEIN SIGNALING%WIKIPATHWAYS_20260211%WP35%HOMO SAPIENS G protein signaling PRKCB PRKCE PRKCD NRAS GNAZ PRKCA PDE4A GNAS-1 AKAP13 ADCY9 PRKAR1B PRKAR1A PRKCQ PRKD1 RRAS ITPR1 PRKCZ PRKAR2B PRKAR2A PDE4D-1 GNG13 AKAP12 AKAP11 AKAP7 AKAP6 GNB2 AKAP4 GNA12 GNAQ AKAP3 PRKD3 AKAP1 GNB1 GNAI3 GNB3 GNB5 GNAI2 CALM1 AKAP8 GNA15 GNA14 GNGT1 PRKACA-1 PDE4B PRKCI PDE8B PDE8A PLCB3 GNAO1 PDE4C PDE1C SLC9A1 PDE1B RHOA PDE1A AKAP9-1 GNAI1 KCNJ3 GNG10 ADCY4 ADCY3 GNA11 ADCY2 ADCY1 KRAS PDE7B ADCY8 PDE7A ADCY7 ADCY6 ADCY5 PPP3CA PRKACB-1 PPP3CC GNG5 HRAS GNG4 AKAP5 GNG8 ARHGEF1 GNAL PRKCG GNA13 PRKCH AKAP10 ATM SIGNALING%WIKIPATHWAYS_20260211%WP2516%HOMO SAPIENS ATM signaling TLK1 NBN CDC25A SMC1A CASP2 IKBKG CDC25C MAPK9 BID MDM2-2 CCNB1 RAD50 MDC1 CRADD RAD51 CREB1 CDKN1A ABL1 CDK1 TP73 RAD9A GADD45A TP53BP1 CDK2 JUN ATF2 CCNE1 ATM MRE11 TP53 BRCA1 CHEK2 CHEK1 RIPK1 PIDD1 MDM4 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260211%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 CYCS-1 CASP7 CASP2 NFKB1 MAPK10 BID CASP9 HSPA1A;HSPA1B CASP3 FAS FADD APAF1 FASLG CASP8 MAP3K1 TNFRSF1A CASP6 RIPK1 AIFM1 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP4784%HOMO SAPIENS Proteoglycan biosynthesis CHST3 SLC26A2 CHST14 XYLT2 B4GALT7 XYLT1 SLC35B3 SLC35B2 EXT1 CANT1 BPNT2-1 EXTL3 CSGALNACT1 B3GAT3 PAPSS2 B3GALT6 EXT2 CHSY1-1 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260211%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members BTRC SKP1 TNK2 APC RBX1 CUL1 PARP10 CTNNB1 PARP1 AXIN1 DVL1 TNK1 DVL2 DVL3 PLK1 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260211%WP2328%HOMO SAPIENS Allograft rejection TGFB1 CASP7 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E BHMT2 PDGFRA PECR AGTR1 FAS CXCL9 LRRK2 C8A CXCR5 COL5A1 HARS1 TNF CASP8 PRKCZ CXCL13 CTLA4 HLA-DOA HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 HLA-DOB C8B HLA-DPB1-1 HLA-DPA1 HLA-DQB2;HLA-DQB1 HLA-DMB VIM CCL19 HLA-DRA CCL21 FASLG CSNK2A2 C5 CD86 C6 IL21 C1QB C7 IL22 CD40 C9 CD80 C2 CD55 HLA-DMA IL12B IL12A LOC110384692;C4A;C4B_2;C4B GABPA C3-1 STAT1 CXCL11 CD40LG CASP9 IFNG IL10 VEGFA CD28 CASP3 CXCL12 IL13 FOXP3 IL2 IL1B IL4 IL5 C1QC IL17A CXCL8 PRF1 IL2RA GZMH;GZMB-1 GDNF ABCB1 IL1A PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260211%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome FSHB LHB CGA MDM2-2 PCSK1 NUP133 POMC GNRH1 NUP85 DLX5 TPR CCND2 CDC6 PRKCZ NUP107 RNF8 TACR3 CDKN2A NUP98 RAE1 EIF4E BDNF GHRH GHRL MSX1 GABRR3 UBE3A GABRR1 HERC2 UBE2N CDKN2B CDKN2C NGF NUP188 POM121;POM121C NDN GLE1 GABRR2 NDC1 NUP214 NUP210 NUP93 NUP50 CYFIP1 FEZ1 MAGEL2 FEZ2 FMR1 NUP54 MDM4 OCA2 NUP205 SLC45A2 SEH1L SNRPN NUP58-2 AAAS GABRG3;GABRG2 NUP160 BBS4 NHLH2 AHCTF1 NUP42 RANBP2 NUP62 E2F1 NUP155 NUP153 ATP10A NUP35 MKRN3 NUP37 KISS1 NUP43 INS;INS-IGF2 SNURF TUBGCP2 TUBGCP5 NIPA1 GABRB3 TUBGCP6 TUBGCP3 TUBGCP4 NIPA2 GABRD CDK4 GABRA5 SEC13 NUP88 GABRG1 RB1 TYR CDK6 TP53 CCND1 OXT-1 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP453%HOMO SAPIENS Inflammatory response pathway CD40 CD80 THBS3 IL2RG FN1 LAMB2 COL1A1 LAMB1 CD40LG IFNG IL4R COL1A2 CD28 LAMC1 IL2 IL4 IL5 IL5RA TNFRSF1A LAMC2 LCK IL2RA IL2RB LAMA5 TNFRSF1B ZAP70 COL3A1 THBS1 VTN CD86 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260211%WP4521%HOMO SAPIENS Glycosylation and related congenital defects TUSC3 MAGT1 MGAT2 DPM1 DPAGT1 ALG6 PMM2 SRD5A3 DOLK MPI ALG1 GMPPB B4GALT1 DPM2 ALG8 MPDU1 ALG9 ALG2 ALG14 ALG3 MOGS ALG12 ALG11 DPM3 CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260211%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis NFATC2 PLCG1 LCK CABIN1 CD4 PPP3CA HDAC1 ATP2A1 PPP3CB CD8A PPP3CC CD8B;CD8B2 ITPRIP ZAP70 HDAC2 CALM1 MEF2D CAPN2 EP300 NR4A1 RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260211%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway PTK2 NFKBIA NRAS CASP7 STAT3 FN1 MSH2 MAPK9 MAPK8 GRB2 SOS1 GRB14-1 CTNNB1 PXN RASA1 STAT5A STAT5B MMP2 MAPK12 MAPK13 NFKB1 MAPK11 BIRC5 GRB7 RAC1 ANGPT4 ANGPT2 IKBKG EGFR STMN1 ANGPT1 PAK1 NOS1 PIK3R1 CASP9 RS1 TNIP3-2 TEK CHUK ANGPTL1 TIE1 RAD51 TNIP1 TNIP2 MYC MAPK1 AKT1 PIK3CA MAPK3 YAP1-1 CRK FOXO1-1 DOK2 MAPK14 BAX ITGB1 KRAS NOS2 IKBKB BAD HRAS NCK1 TP53 SRC ERBB2 EIF4EBP1 RELA PTPN11 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260211%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia LYL1 SKP2 CSF1R PIM1 KIT PIM2 PDGFRB PDGFRA GAB2 ABCG2 FLT1 ABCB1 NOP2 ABL1 FOXO3 SPRED2 MYC BCR GADD45A CDKN1B CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260211%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways PHGDH STAT3 BHLHE41 PGM2 RAPGEF5 VHL KDR PDGFRB PDGFRA SHMT1 ZEB1 PDGFB SDS HIF1A PFKL PFKM ENO2 GPI ENO3 CDH13 ACLY PKLR KCNJ2 ALDOB ACACA FASN BAP1 PTEN CREBBP PGK1 ALDOC ENO1 HK1 MDH1 EP300 CEP290 EGFR FLT1 GAPDH-1 RPTOR VEGFA DEPTOR SLC2A1 MLST8 MAP2K5 SSPN PLOD2 KSR1 ARNT ALDOA KDM5C ME1 EFCAB3 HK3 AKT1 PBRM1 TOX2 ENPP3 PGM1 SDSL PGBD5 LDHD ACACB HK2 PKM RHEB SETD2 AKT1S1 MTOR SQSTM1 CAMK1 PSPH GRB10 LDHB LDHA;LDHC LDHA TPI1 PSAT1 SHMT2 PFKP TSC2 TSC1}