S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Enoph1 Adi1 Kyat1 Mri1 Apip L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III Mpst Got1 Cisd1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) Gad1 Gad2 ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II Cyp2a3 Cyp19a1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) Fads2 Elovl5 Hsd17b12 Ehhadh METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI Ldhd GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation Gcdh Echs1 Acat1 Acat2 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis Asns PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation Pecr Aldh3a2 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II Ubiad1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Synj2 Inppl1 Inpp5d Itpka Inpp5f Synj1 Inpp5a Itpkc Itpkb Ipmk Bpnt2 Impa2 Ocrl Pten Impa1 Inpp5k Inpp1 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) Cbs Cth SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis Dhodh Rrm2 Tyms Rrm2b Cad Nme3 Nme2 Nme4 Nme1 Cmpk2 Cmpk1 Dtymk Umps Nme7 Nme6 Ctps2 Ntpcr Ctps1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis Gphn SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis Aanat Tph2 Ddc Tph1 Asmt ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis Tm7sf2 Hsd17b7 Nsdhl Lbr &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis Acsl1 Acsm3 Acsbg1 Acsm4 Fads2 Slc27a2 Acsm5 Acsbg2 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II Rnmt Cmtr2 Cmtr1 Rngtt PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis Alox15 Ltc4s Gstm4 Gpx4 Alox12 Alox5 Dpep1 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Fdps Idi1 Hmgcs1 Pmvk Ggps1 Hmgcr Mvd Hmgcs2 Acat1 Acat2 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation Gls2 Gls L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation Hgd Tat Fah Hpd NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation Adh4 Maoa Maob Comt Tomt Aldh2 Adh6 Aldh3a2 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II Nagk Amdhd2 Gnpda2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation Hal Uroc1 Mthfd1 Ftcd NADH REPAIR%BIOCYC%PWY-6938 NADH repair Naxe URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) Dpys Dpyd Upb1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds Synj2 Pip5k1b Inppl1 Plcb4 Plcb3 Pikfyve Ip6k1 Pik3c3 Ip6k2 Plcb2 Plcb1 Ip6k3 Sacm1l Pi4k2a Ippk Plcg1 Plcg2 Mtmr14 Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pip4k2c Pik3r2 Pik3r3 Pik3r4 Pip4k2a Pi4kb Plch2 Plcd1 Plcd4 Plcd3 Itpk1 Cdipt Inpp5d Pik3cg Itpka Pik3cb Pik3cd Pip4p2 Synj1 Inpp5a Pip4p1 Itpkc Pi4k2b Itpkb Plcz1 Ipmk Pik3c2b Plce1 Pik3c2a Ocrl Pik3c2g Pten Fig4 Mtmr3 Inpp5k Ppip5k1 Pip5k1c L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation Prodh METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I Glo1 Hagh L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation Gpt2 Gpt ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss2 Acss3 Acss1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I Aoc3 Smox Sat2 Sat1 Paox L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis Pah ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing Aloxe3 Slc27a4 Cyp4f39 Alox12b Cers3 Tgm1 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis Umps Dhodh Cad GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation Pnp Gda Xdh SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation Cat Sod3 Sod2 Sod1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis Impa2 Isyna1 Impa1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) Ndufab1 Ndufc1 Ndufc2 Sdhd Sdhc Sdhb Sdha Ndufa12 Ndufa11 Cox6a1 Cox7b Uqcrfs1 Ndufs1 Ndufs3 Ndufs2 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs6 Mt-co3 Mt-co2 Ndufs8 Uqcrq Ndufa1 Ndufa3 Ndufa2 Ndufa5 Ndufa4 Ndufa7 Ndufa6 Ndufa8 Ndufb11 Ndufb10 Cox7a2 Cox5a Cox5b Mt-co1 Cyc1 Mt-nd5 Mt-nd4 Ndufb2 Mt-nd6 Mt-nd1 Uqcrc2 Ndufb3 Mt-nd3 Uqcrc1 Ndufb6 Mt-nd2 Mt-nd4l Ndufb5 Ndufb8 Ndufb7 Ndufb9 Cox8a Ndufv2 Ndufv1 Ndufv3 Uqcr11 Ndufa10l1 Mt-cyb DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Dhdds Nus1 Srd5a3 Dolk Dhrsx PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis Adsl Impdh2 Impdh1 Ak3 Gmps Rrm2 Ak2 Ak4 Rrm2b Adss2 Ak7 Nme3 Pfas Nme2 Ak8 Nme4 Atic Nme1 Ppat Guk1 Gart Paics Nme7 Nme6 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) Nmnat1 Nmrk1 Nmnat2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt Gad1 Gad2 Glud1 Aldh5a1 Abat PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6pd Pgls UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) Ubiad1 Coq5 Coq6 Coq7 Pdss2 Coq2 Coq3 Coq4 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis Impdh2 Nme7 Nme6 Impdh1 Gmps Rrm2 Rrm2b Nme3 Nme2 Nme4 Nme1 Guk1 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis Shmt2 Psat1 Shmt1 Phgdh Psph Vps29 PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage Nme7 Nme6 Dguok Dck Nme3 Nme2 Nme4 Nme1 Guk1 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) Sult1a1 Dio1 Dio2 Ugt1a9 Ugt2b34l1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation Gls2 Gls Asns VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle Nqo1 Ggcx Vkorc1l1 Vkorc1 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I Por Cyp4x1 Cyp2u1 Cyp2a3 Cyp2s1 Cyp1b1 Cyp1a2 Sult1a1 Ugt2b34l1 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation Pnp Ada GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I Nat8 Gstm2 Gsto2 Mgst3 Gstp1 Gstt2 Mgst2 Mgst1 Gstt1 Gsta6 Gsta3 Gsta1 Gsta2 Anpep Gstm7 Gstm5 Gstk1 Gstm1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Mthfd1 Gart ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis Lta4h Ptgs2 Alox5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I Agmat PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Chkb Selenoi Pcyt2 Cept1 Etnk2 Etnk1 CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Sqle Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Tm7sf2 Hsd17b7 Nsdhl Lbr PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation Nme7 Nme6 Nme3 Nme2 Nme4 Nme1 Cmpk2 Cmpk1 Dtymk PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis Alox15 Gpx4 Alox12 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) Dhtkd1 Aadat Pycr1 Pipox CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Hyal1 Hyal5 Hyal4 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis Tyr ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis Atp6v0b Atp5f1d Atp5f1c Atp5pb Atp6v1e1 Atpaf1 Atp6v0a1 Atp6v1c1 Atp5pf Atpaf2 Atp5po Atp6v0c Atp6v1a Mt-atp6 Atp5mc1 Atp6v1b2 Vps9d1 Atp6v0d1 Atp5mc3 Atp5mc2 Atp5mf Atp5me Atp6v0e1 Atp5mg Atp6v1g1 Atp5f1b Atp5f1a Atp6v1f Atp6v1d Atp6v1h FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation Mthfd1l Shmt2 Shmt1 Mthfd1 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis Psat1 Phgdh Psph Vps29 L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I Aspg Asrgl1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I Acod1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis Pfas Ppat Gart PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I Cda Uck1 Uck2 Uckl1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis Acat1 Acat2 Fdps Sqle Idi1 Ebp Dhcr24 Hmgcs1 Pmvk Sc5d Kcnh7 Ggps1 Dhcr7 Hmgcr Fdft1 Mvd Lss Hmgcs2 Tm7sf2 Hsd17b7 Nsdhl Lbr PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III Arg2 Odc1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation Cda Upp1 Upp2 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Hmgcs2 Acat1 Hmgcl Bdh2 Bdh1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation Akr1a1 Cryl1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Pip5k1b Pip4k2b Pip4k2c Pip4k2a Pi4kb Plch2 Plcd1 Plcd4 Plcd3 Cdipt Plcb4 Plcb3 Pi4k2b Plcz1 Plcb2 Plce1 Plcb1 Pi4k2a Plcg1 Plcg2 Pip5k1c ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV Aldh2 Acss2 Acss3 Cat Acss1 Aldh3a2 CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) Cyp2e1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation Hsd17b10 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Acadsb Echs1 Acat1 Acat2 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis Agxt2 Agxt ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) Fads2 Elovl7 Fads1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis St3gal5 St3gal2 B3galt1 B3gnt5 B3gnt2 Fut2 A4galt B4galt1 Fut1 B4galt2 B4galt3 B4galt4 B3galnt1 B4galt6 St6gal1 B4galnt1 B3galt5 B3galt4 St8sia2 St8sia3 Ugcg St8sia1 St3gal6 St3gal4 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I Hmox1 Hmox2 Blvra Ugt1a5 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B3gnt5 B3gnt2 B4galt1 B4galt2 B4galt3 B4galt4 B4galt6 St6gal1 St8sia2 St8sia3 Ugcg St3gal6 St3gal4 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fcsk Fpgt GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Gmds THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III Tpk1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation Dpys Dpyd Upb1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation Nnt CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation Aldh7a1 Chdh ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI Adk PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis Gnpat Pcyt1b Pcyt1a Far2 Far1 Chka Peds1 Agpat1 Pcyt2 Cept1 Etnk2 Etnk1 Chkb Selenoi L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis Tyr L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) Kmo Ido2 Acmsd Ido1 Dhtkd1 Kyat1 Tdo2 Aadat Haao Kynu Got2 Aldh8a1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) Cyp2a3 Cyp19a1 Hsd17b11 Hsd17b3 Hsd17b1 Hsd17b7 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) Acsl1 Acsm3 Acsm4 Fads2 Elovl5 Acsm5 Elovl7 Fads1 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation Suox HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis Hdc GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis St3gal5 St3gal2 B3galt4 Ugcg St8sia1 B4galt6 St6gal1 B4galnt1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3galt5 B3galt1 Fut2 Abo2 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III Cyp2e1 Akr1b10 Akr1b1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat2a Mat1a PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation Enpp2 Tmem86b SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis Dhodh Cad Nme3 Nme2 Nme4 Nme1 Cmpk2 Cmpk1 Umps Nme7 Nme6 Ctps2 Ctps1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Ipmk Ippk Itpk1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis Shmt2 Shmt1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis Fads6 Scd Acot2 Acot3 Acot4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis Tbxas1 Cbr1 Hpgds Hpgd Ptges Ptgds Ptgs2 Ptgis Ptges2 Akr1c3 Ptgs1 Ptgr2 Ptgr1 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation Mtmr14 Synj2 Inppl1 Inpp5d Inpp4a Inpp4b Inpp5f Pip4p2 Synj1 Pip4p1 Ocrl Sacm1l Pten Mtmr3 Inpp5k ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis Elovl4 Tecr Hsd17b12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) Ppcdc Coasy RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis Alox15 Ephx3 Gpx4 Alox12 Alox5 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) Cyp4x1 Cyp2e1 Cyp2u1 Cyp2a3 Cyp2s1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis Tbxas1 Hpgds Hpgd Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 Ephx3 Dpep2 Cyp4f18 Cyp2j4 Cyp4f4 Cyp2d4 Alox15b Lta4h Ptgs2 Gstm4 Gpx4 Alox12 Alox5 Dpep1 Alox15 Ltc4s PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination Padi3 Padi4 Padi1 Padi6 Padi2 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) Pah PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II Ptdss2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Synj2 Inpp5d Inppl1 Itpka Synj1 Inpp5a Itpkc Itpkb Ipmk Ocrl Pten Inpp5k INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis Ip6k1 Ip6k2 Ipmk Ip6k3 Ippk Ppip5k1 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism Dio3 Dio1 Dio2 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway Txnrd2 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis Ptgs2 Alox5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate Acly KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Oxct1 Acat1 Bdh2 Bdh1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation Aldh1b1 Aldh3b1 Aldh3a1 Pgm2 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation Alox15 Alox12 Alox5 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine Bhmt Bhmt2 Mtr SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation Por Cyp4x1 Maoa Cyp2u1 Cyp2a3 Cyp2s1 Cyp1b1 Cyp1a2 Sult1a1 Ugt2b34l1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Acmsd Dhtkd1 Aldh8a1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions Gpx3 Gsr Gpx7 Gpx4 Gpx2 Gpx1 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage Nmnat1 Nmnat2 Nampt HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation Aoc1 Hnmt CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis Agpat3 Lclat1 Agpat4 Cds2 Agpat2 Agpat1 Cds1 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Gpam Abhd5 Mboat2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Bpgm FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III Fa2h Hacl1 Aldh3a2 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis Bpgm Gpi Mdh1 Mdh2 Eno1 Gapdhs Aldob Aldoc Eno3 G6pc1 Eno2 Aldoa G6pc3 Pc Pgk1 Pgam2 Tpi1l2 Pgk2 Fbp1 Pck1 Fbp2 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I Maoa Maob Aldh2 Aoc3 Aldh3a2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Rpia Rpe Taldo1 Tkt VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II Elovl1 Tecr Hsd17b12 Elovl7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) Acsl1 Acsm3 Acsbg1 Acsm4 Fads2 Slc27a2 Elovl5 Acsm5 Hsd17b12 Acsbg2 Elovl7 Fads1 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Ipmk Itpk1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle Ggct Gclc Gss Cndp2 Gclm Oplah UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I Ctps2 Ntpcr Ctps1 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis Hk3 Pygb Pygl Pgm2 Pygm Gck Pgm1 Hk2 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation Aldh6a1 Bckdhb Bckdha Dbt Abat Bcat1 Dld Bcat2 Echs1 Hibch Hibadh ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) Ate1 Naa20 Naa25 Ntaq1 Metap1 Apeh Metap2 Ntan1 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis Ptgs2 Alox5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis Got1l1 Got1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II Hk3 Pgm2 Gck Pgm1 Hk2 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II Maoa TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II Rtraf Fam98b Tsen2 C9h2orf49 Tsen34 Rtcb Tsen15 Ddx1 Tsen54 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage Cda Tk2 Tyms Dck PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis Nme7 Nme6 Ntpcr Rrm2 Tyms Rrm2b Nme3 Nme2 Nme4 Nme1 Dtymk L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis Aldh18a1 Pycr2 Pycr1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gstp1 Gsta3 Gsta1 Gsta2 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation Impdh2 Impdh1 Pnp Gda Ada Nt5c1a Xdh Nt5e Nt5c3a L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis Cbs Cth Ahcy Mat2a Mat1a L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle Enoph1 Adi1 Kyat1 Mri1 Srm Mat2a Apip Mat1a D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation Synj2 Inppl1 Inpp5f Synj1 Inpp5a Bpnt2 Impa2 Ocrl Impa1 Inpp5k Inpp1 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation Acadsb BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Zfyve16 Bmpr2 Bmp2 Smad4 Acvr2a LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Ltc4s Dpep2 Lta4h Gstm4 Alox5 Dpep1 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis Hsd3b1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis Glud1 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II Rbp4 Rbp1 Xdh GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclc Gss Gclm DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation Maoa Maob Comt Aldh3a2 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis Alox15 Ephx3 Alox12 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I Got1l1 Got1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis St3gal5 Ugt8 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I Sord PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate Ldhb Ldhc PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III Maoa Maob Aldh2 Aldh1b1 Aldh3b1 Aldh3a1 Sat2 Sat1 Aldh3a2 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt1 Ckm Ckb QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) Qtrt2 Qtrt1 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation Mccc2 Hmgcll1 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Hmgcl Mccc1 Auh Ivd GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation Aspg Asrgl1 Aga Got1 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation Maoa Aldh2 Adh6 Sult1a1 Ugt2b34l1 Aldh3a2 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis Adsl Ak3 Ak2 Ak4 Adss2 Ak7 Ak8 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis Acot9 Acot7 Acot8 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II Plaat3 Plaat1 Plaat5 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Kmo Ido2 Ido1 Tdo2 Haao Kynu UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis Uxs1 Ugdh PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases Pla2g10 Plcb4 Plcb3 Plcb2 Plcb1 Plcg1 Plcg2 Plaat3 Plaat1 Plaat5 Plch2 Pla2g2e Plcd1 Pla2g2d Plcd4 Pla2g2f Plcd3 Pla2g2a Pla2g4e Pla2g4d Pld4 Pla2g4a Pld6 Pld1 Pld3 Plb1 Plcz1 Pld2 Pla2g12a Plce1 Pnpla8 Pla2g5 Pla2g3 Pla2g6 Pla2g1b Oc90 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis Sqle Fdft1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis Srd5a1 Srd5a2 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I Sqle Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Tm7sf2 Hsd17b7 Nsdhl Lbr OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis Gclc Gss Gclm Got1 COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis Pank3 Pank1 Ppcdc Coasy SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation Aldoa Tkfc Khk Tpi1l2 Aldob Aldoc PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis Prps1 Prps2 Prps1l1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage Cda Tk2 Tyms Dck Nme3 Nme2 Nme4 Nme1 Cmpk2 Cmpk1 Dtymk Nme7 Nme6 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis Chkb Pcyt1b Pcyt1a Chka Chpt1 Cept1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization Maoa Maob Aldh2 Adh6 Sult1a1 Qprt Ugt2b34l1 Nadsyn1 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp1a2 Aanat Tph2 Ddc Tph1 Asmt Cyp2a3 Gcdh Echs1 Tdo2 Acat1 Acat2 Haao Kynu Aldh3a2 Aldh8a1 Nmnat1 Kmo Akr1a1 Ido2 Nmnat2 Acmsd Ido1 Dhtkd1 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) Hsd17b4 Acaa1b Hsd17b10 Acsbg1 Hadh Slc27a2 Acsbg2 Ehhadh Echs1 Acox1 Acox2 Scp2 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine Akr1a1 Maob Ddc Aldh3a2 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging Lars2 Gars1 Qars1 Lars1 Farsa Farsb Cars1 Vars2 Wars2 Aars2 Rars1 Wars1 Aars1 Rars2 Kars1 Sars2 Sars1 Fars2 Eprs1 Nars1 Nars2 Tars3 Tars2 Iars1 Tars1 Hars1 Pars2 Dars2 Yars2 Yars1 Dars1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Amdhd2 Gnpda2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis Tat SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage Adsl Impdh2 Impdh1 Adk Ak3 Gmps Rrm2 Ak2 Ak4 Rrm2b Adss2 Ak7 Nme3 Nme2 Ak8 Nme4 Nme1 Guk1 Nme7 Hprt1 Nme6 Aprt Pnp Ada SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 Gdf1 Kdsr PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP Nme7 Nme6 Ntpcr Rrm2 Tyms Rrm2b Nme3 Nme2 Nme4 Dctd Nme1 Dtymk UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis Nme7 Nme6 Ctps2 Ctps1 Nme3 Nme2 Nme4 Nme1 Cmpk2 Cmpk1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine Shmt2 Aldh7a1 Chdh Shmt1 Bhmt Dmgdh TCA CYCLE%BIOCYC%PWY66-398 TCA cycle Sdhd Idh3b Sdhc Cs Sdhb Idh3g Sdha Suclg1 Suclg2 Ogdh Aco2 Mdh1 Mdh2 Dld Fh Idh3a Dlst N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis Emg1 Tsr3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation Hsd17b10 Acsbg1 Hadh Slc27a2 Acsbg2 Hadha Hadhb Echs1 Acaa2 Eci1 Scp2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 Gdf1 Kdsr ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) Elovl7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II Sord Adh1 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis St3gal5 B3galt5 B3galt1 B3gnt5 Ugcg Fut2 B4galt6 St6gal1 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation Sdsl TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling Pcbd1 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis Srm TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis Gch1 Spr Pts L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) Gcdh Echs1 Tdo2 Acat1 Haao Acat2 Kynu Aldh8a1 Kmo Ido2 Acmsd Ido1 Dhtkd1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation Oga Ogt CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis Hccs RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I Rbp4 Rbp1 Aldh1a2 Aldh1a1 Aldh1a3 Rdh16 Sdr16c5 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide St8sia2 B4galt1 Fut1 Abo2 B4galt2 B4galt3 Fut9 Chst1 St3gal4 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation Nme7 Nme6 Nme3 Nme2 Nme4 Nme1 Cmpk2 Cmpk1 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation Dpys Dpyd Cda Upp1 Upp2 Upb1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) Dio3 Dio1 Dio2 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) Acsl1 Acsm3 Acsm4 Fads2 Elovl5 Acsm5 Fads1 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B3gnt2 B4galt1 B4galt2 B4galt3 Gcnt3 Gcnt2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) Eci1 Eci2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis Pklr Pfkl Pkm Pfkm Pfkp Bpgm Hk3 Gpi Eno1 Gck Gapdhs Aldob Hk2 Aldoc Eno3 Eno2 Aldoa Pgk1 Pgam2 Tpi1l2 Pgk2 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) Cbs Cth HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B3galt5 B3gnt2 Lalba Fut2 B4galt1 B4galt2 B4galt4 Gcnt3 St6gal1 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation Impdh2 Impdh1 Pnp Xdh Nt5e HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Fech Cpox Urod Ppox MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle Cpt1a Cpt2 Cpt1b Cpt1c Slc25a20 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis Trpc1 Tyrp1 Tyr Dct FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) Oxsm Acsf3 Mcat Ndufab1 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis B3galt5 St3gal2 Ugcg Fut2 A4galt Fut1 B3galnt1 B4galt6 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation Treh Hk3 Gck Hk2 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis Cyp2c11 Ephx3 Ephx1 Ephx2 Ephx4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) Rdh10 Rpe65 Rbp2 Rbp3 Dhrs9 Lrat Rlbp1 Rbp4 Rbp1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis Hsd3b1 Srd5a1 Srd5a2 Hsd17b3 Cyp17a1 Akr1c3 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis Impdh2 Nme7 Nme6 Impdh1 Gmps Nme3 Nme2 Nme4 Nme1 Guk1 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis Rdh10 Rbp2 Dhrs9 Lrat Ces4a Ces5a Pnlip Lipc Ces2h Ces1d Bco1 Rbp4 Rbp1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis Alox15 Ephx3 Ptgs2 Gpx4 Cyp2d4 Alox12 Alox5 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis Pip5k1b Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pik3r2 Pik3r3 Pik3r4 Pi4kb Cdipt Pik3cg Pik3cb Pik3cd Pikfyve Pi4k2b Pik3c3 Pik3c2b Pik3c2a Pik3c2g Sacm1l Fig4 Pi4k2a Pip5k1c UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Gnpnat1 Uap1 Pgm3 Hk3 Gpi Gnpda2 Gck Hk2 Gale 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I Aldh5a1 Abat CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Cdo1 Got1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis Acsl1 Acsbg1 Acot2 Acot3 Slc27a2 Elovl6 Acot4 Acot7 Hsd17b12 Acsbg2 Elovl7 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation Abat TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation Hoga1 Prodh2 Got2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation Cyp4f4 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) Fads2 Elovl5 Hsd17b12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis Lss SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Acsl1 Acsbg1 Slc27a2 Acsbg2 Ptgr1 Acer1 Acer2 Asah2 Asah1 Sphk2 Sphk1 Sgpp2 Sgpp1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Pnp Ada Pgm2 PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation Cda Upp1 Upp2 Tymp D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Mtmr14 Pip4k2c Pip4k2a Plch2 Plcd1 Plcd4 Plcd3 Plcb4 Plcb3 Pip4p2 Pip4p1 Plcz1 Plcb2 Plce1 Plcb1 Mtmr3 Plcg1 Plcg2 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis Akr1c1 Srd5a1 Akr1c2 Srd5a2 Akr1c3 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I Mthfd1l Shmt2 Mthfd2l Shmt1 Aldh1l2 Mthfd2 Mthfs Mthfr Mthfd1 Mtr GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation Gk5 Gk Gk2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation Mpi L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation Ahcy Mat2a Mat1a ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III Hprt1 Pnp Ada REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation Gpx3 Gpx7 Cat Sod3 Sod2 Gpx6 Sod1 Gpx5 Gpx8 Gpx2 Gpx1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation Pnp Ada Nt5c1a Xdh Nt5e Nt5c3a ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) Cyp4x1 Cyp2e1 Cyp2u1 Cyp2a3 Cyp2s1 Akr1b10 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis Aldh9a1 Shmt1 Tmlhe Bbox1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Synj2 Inppl1 Itpk1 Inpp5d Itpka Synj1 Inpp5a Itpkc Itpkb Ipmk Ocrl Ippk Inpp5k LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis Alox15 Gpx4 Alox12 Alox15b Alox5 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation Lipg Dagla Lipe Lipf Lpl Pnpla3 Cel Daglb Pnliprp2 Pnpla2 Pnlip Lipc CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Nanp Nans Cmas Gne CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis Ptpmt1 Crls1 Pgs1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation Comt CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis Gamt Gatm UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) Ugdh GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis Nme7 Nme6 Rrm2 Rrm2b Nme3 Nme2 Nme4 Nme1 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis Pfkfb4 Pfkfb3 Tigar Pfkfb2 Pfkfb1 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis Ggps1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) Shmt2 Tyms ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis Nme7 Nme6 Rrm2 Rrm2b Nme3 Nme2 Nme4 Nme1 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Nmnat1 Nmnat2 Qprt Nadsyn1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I Rnmt Rngtt DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis Cbr1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I Ptdss1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) Fads2 Elovl5 Hsd17b12 Elovl7 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) St8sia2 B3gnt2 B4galt1 B4galt2 St6gal2 B4galt3 Gcnt3 St6gal1 Gcnt2 St3gal4 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III Cyp2e1 Aldh2 Acss2 Acss3 Acss1 Aldh3a2 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II Aldh2 Acss2 Acss3 Acss1 Aldh3a2 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation Bckdhb Bckdha Dbt Dld Mcee Pccb LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III Glb1 Lct Glb1l3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV Aox1 Cyp4x1 Fmo3 Cyp2u1 Fmo2 Cyp2a3 Cyp2s1 Fmo5 Fmo4 Ugt1a5 Ugt2b34l1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) Galt Galm Galk1 Pgm2 Pgm1 Gale UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Gnpnat1 Uap1 Pgm3 Hk3 Gpi Gfpt1 Gfpt2 Gck Hk2 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis Gpt2 Gpt INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis Adsl Atic Paics L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) Aldh7a1 Dhtkd1 Aass Aadat L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis Sars2 Sars1 Sephs1 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation Slc27a2 Hacl1 Phyh Aldh3a2 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis Fdps Ggps1 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis Tyw3 Tyw1 Lcmt2 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I Napepld Plaat1 Plaat5 Pla2g1b Enpp2 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation Acadsb Echs1 Acat1 Acat2 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis Nmnat1 Kmo Ido2 Nmnat2 Ido1 Tdo2 Qprt Haao Nadsyn1 Kynu LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation Acsl1 Acsbg1 Acsl3 Slc27a2 Acsbg2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) Tst 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis Dagla Ddhd1 Daglb Plcb1 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) N6amt1 Pnp Slc20a2 Slc20a1 Trmt112 Aqp9 Slc34a2 Aqp7 Slc2a1 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation Cyp4x1 Cyp2u1 Cyp2a3 Cyp2s1 Cyp2b2 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I Pgm2 Pgm1 Ugp2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis Lta4h Ptgs2 Alox5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis Aldh18a1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation Papss2 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis Gmppa Pmm2 Gmppb Pmm1 Gpi Mpi CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Sqle Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Tm7sf2 Hsd17b7 Nsdhl Lbr UREA CYCLE%BIOCYC%PWY-4984 urea cycle Asl Cps1 Ass1 Otc GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) Shmt2 Shmt1 Bhmt Dmgdh SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) Tst Suox HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis Fech Cpox Alad Urod Alas2 Ppox Hmbs Uros PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I Mcee Pccb L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation Bckdhb Bckdha Dbt Dld Sds Sdsl GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage Hprt1 Pnp CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle Asl Ass1 Nos3 Nos2 Nos1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation Cbs Cth Ahcy Bhmt Mcee Bhmt2 Pccb Mtr Bckdhb Cdo1 Bckdha Dbt Suox Dld Mat2a Mat1a Got1 TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis Alad Alas2 Hmbs Uros MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway Idi1 Hmgcs1 Pmvk Hmgcr Mvd Hmgcs2 Acat1 Acat2 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II Fmo1 Ado ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) Gsto1 Glrx DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis Agpat3 Lclat1 Agpat4 Plpp4 Agpat2 Mogat1 Plpp2 Plpp3 Plpp1 Dgat2 Plppr4 Agpat1 Dgat1 Plppr2 Plppr3 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Gpam Abhd5 Mboat2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Ipmk Itpk1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis Ddc Th Dbh 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis Tyw3 Tyw1 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I Csad Fmo1 Cdo1 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I Aprt MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle Mdh1 Mdh2 Got1 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor Atf2 Mapk8 Ccne1 Fkbp1a Mapk1 Irf2bp1 Ctnnb1 Map3k7 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Myc Cdc27 Akt1 Tp53 Skp1 Pdk1 Pard6a Dcp1a Rbx1 Prkcg Eid2 Prkcb Hgs Ube2d3 Prkcd Ube2d2 Ube2d1 Nup153 Btrc Cdc25a Atf3 Jund Sdc2 Pxn Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Ar Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Tp73 Jun Cops5 Vdr Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Ptk2 Stk11 Hspa8 Crebbp Smad2 Map4k1 Smad3 Snw1 Wwtr1 Sparc Smad4 Cdk6 Fnta Cdk4 Cdk2 Cul1 Cdc16 Cdk1 Junb Daxx Smad6 Smad7 Hnf4a Rhoa Tgif1 Ing2 Xpo1 Ctcf Hdac1 Foxo4 Tfdp2 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Zeb1 Rbl2 Zeb2 Rbl1 Anapc10 Foxh1 Smurf2 Smurf1 Skil Pik3r1 Crk Pik3r2 Lef1 Stk11ip Nfyb Nfya Ppm1a Nfyc Prkar1b Strap Hoxa7 Map2k6 Bcar1 Fzr1 Ncoa1 Ap2b1 Arrb2 Cd44 Runx2 Rb1 Mapk14 Tgfbr3 Prkar2a Map2k3 Mef2c Brca1 Zfyve9 Rock1 Tgfbr1 Cdkn1a E2f5 Tgfbr2 BDNF%IOB%BDNF BDNF Mapk8 Mapk1 Mapk3 Akt1 Mapk9 Shc4 Shc1 Irs1 Plcg1 Irs2 Ptk2b Elk1 Gsk3b Ntrk2 Ntrk1 Raf1 Foxo3 CCR1%IOB%CCR1 CCR1 Gna14 Ptk2 Rela Ccl7 Ccl5 Mapk14 Pxn Mapk1 Ccl4 Ccl3 Nfkb1 Stat1 Mapk3 Ptk2b Prkcd Ccr1 Zap70 Creb3 Src LEPTIN%IOB%LEPTIN Leptin Pde3a Itgav Socs7 Rps6kb1 Ptpn11 Slc2a4 Jak3 Jak2 Pik3r1 Rps6 Egfr Pik3r2 Khdrbs1 Sp1 Lep Prkce Stat3 Grb2 Lepr Ptk2 Mapk1 Mapk14 Mapk3 Irs1 Irs2 Prkcd THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin Shc1 Mapk1 Stat3 Map2k1 Stat5b Atxn2l Mpl Gab1 Mapk3 Jak2 Foxo3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor Lyn Yes1 Kitlg Stat5a Tec Fes Hras Pik3r1 Crk Pik3r2 Atf2 Mapk8 Mapk1 Mapk14 Akt1 Shc1 Plcg1 Gsk3b Prkcb Raf1 Src Rela Stat1 Rps6kb1 Ptpn11 Jak3 Jak2 Rps6 Grb2 Jun Stat5b Socs1 Mitf Socs5 Socs4 Socs6 Matk Crkl Ptpru Gys1 Csf2rb Cltc Sh3kbp1 Cblb Mad2l1 Fgr Hck Dok1 Wipf1 Rps6ka1 Tnfrsf10b Kit Prkca Spred1 Il7r Sos1 Spred2 Inpp5d Rasa1 Eif4ebp1 Cbl Mtor Epor Abl1 Fyn Grap CCR7%IOB%CCR7 CCR7 Mapk8 Rela Foxo1 Mapk14 Mapk1 Cfl1 Ccl19 Ccl21 Ccr7 Rps6kb1 Adrb2 Mapk3 Akt1 Plcg1 Ptk2b Gsk3b Mtor Foxo3 WNT%IOB%WNT Wnt Yes1 Ilk Mark2 Wnt5a Ctbp1 Cdh1 Ywhab Rac1 Lef1 Pi4k2a Ppp1ca Nfatc2 Sfrp2 Ppp2ca Sfrp1 Daam1 Rspo1 Prkaca Dkk1 Mesd Pax2 Gsk3a Frzb Arrb2 Mapk8 Dixdc1 Chd7 Axin1 Ror1 Ror2 Ctnnb1 Lrp1 Map3k7 Arhgef4 Lrp6 Csnk1a1 Nlk Lrp5 Wnt3a Dvl1 Gpc3 Akt1 Dvl3 Wnt7a Wnt2 Wnt1 Wnt4 Wnt3 Tcf7l2 Prkcg Fzd1 Fzd5 Gsk3b Prkcb Jup Fzd4 Fzd6 Prkcd Kremen1 Fzd9 Fzd8 Smad1 Apc Pin1 Tcf4 Pip5k1b Jun Ccnd1 Cdk6 Prkca Rhoa FAS%IOB%FAS Fas Lyn Satb1 Ripk1 Casp1 Bmx Map2k2 Wee1 Diablo Bcl2 Bax Fas Pkn2 Vim Faslg Pkn1 Dffa Rac1 Mapk1 Csnk1a1 Rock1 Mapk3 Cdc27 Akt1 Gsk3b Prkcd Traf3 Psme3 Nedd4 Faf1 Eif2ak2 Arhgdib Stk24 Csnk2a1 Parp1 Traf2 Plec Csnk2b Parg Prkn Rfc1 Mst1 Bcl2l1 Xiap Glrx Casp8ap2 Eif4b Gtf3c3 Map2k1 Lck Tcp1 Btk Anxa4 Fadd Top1 Met Csnk1e Cast Dedd Cd59b Eif3j Max Srf Aifm1 Uso1 Ptpn6 Stk4 Stk3 Ripk2 Prkdc Numa1 Hspb1 Cflar Eif2s1 Bid Ube4b Daxx Pak2 Casp8 Mbd4 Casp7 Rasa1 Tial1 Tia1 Casp9 Casp4 Casp3 Casp6 Fyn Fastk Casp2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Yes1 Vim Erbb2 Pik3r1 Clca1 Rpsa Ywhab Pik3r2 Ywhah Rac1 Ywhae Dsp Eif4e Lama5 Cd151 Itgb4 Lama2 Lama3 Mst1r Mylk3 Ywhaz Pik3r3 Col17a1 Itga6 Ntn1 Ephb2 Pak1 Lamb2 Lamb3 Pik3cg Sfn Lamb1 Pik3cb Pik3cd Rtkn Bad Eif6 Lamc1 Akt1 Shc1 Irs1 Irs2 Prkcd Src Ar Ptpn11 Plec Egfr Grb2 Tp73 Met Ptk2 Smad2 Smad3 Prkca Rhoa Eif4ebp1 Mtor Casp3 Abl1 Fyn NGF%IOB%NGF NGF Dnaja3 Prkci Frs2 Sp1 Mapk1 Elk1 Map2k1 Mapk3 Creb1 HEDGEHOG%IOB%HEDGEHOG Hedgehog Ccnb1 Hhip Stk36 Kif7 Med6 Smo Sufu Kif27 Ywhae Prkaca Arrb2 Ctnnb1 Med23 Dhh Ihh Gli1 Gli2 Shh Grk2 Ptch1 Dyrk1a Sap18 Boc Med12 Med1 GM-CSF%IOB%GM-CSF GM-CSF Lyn Yes1 Stat5a Map2k2 Fes Pik3r1 Pik3r2 Map2k6 Bcar1 Gsk3a Mapk8 Mapk1 Mapk14 Tgfbr3 Map2k3 Mapk3 Bad Akt1 Creb1 Mapk9 Shc1 Plcg1 Elk1 Gsk3b Raf1 Pxn Stat1 Ikbkb Pdia3 Slc2a1 Prdx3 Rps6kb1 Stam2 Syk Rack1 Jak2 Vav1 Tgfb1 Sptan1 Rps6ka2 Pfn1 Csf2 Ezr Ganab Stat3 Stam Grb2 Cct5 Ptprc Map2k1 Dpysl2 Stat5b Sh2b2 Nfkbia Gab1 Bcl3 Park7 Chuk Crkl Csf2rb Ptpn6 Hck Prkca Cbl CCR9%IOB%CCR9 CCR9 Madcam1 Mapk8 Msn Foxo1 Cd226 Itgb7 Mapk14 Mapk1 Ccl25 Itga4 Ccr9 Rps6kb1 Mapk3 Akt1 Cdh1 Ezr Gsk3b Rdx TIE1 TEK%IOB%TIE1 TEK TIE1 TEK Ptk2 Bmx Stat5a Pak1 Mapk14 Mapk1 Map2k2 Fes Nos3 Tie1 Dok2 Tek Nck1 Mapk3 Akt1 Shc1 Elk1 Map2k1 Stat5b Raf1 CCR5%IOB%CCR5 CCR5 Rela Ccl7 Ccl5 Stat5a Ccl4 Cfl1 Stat1 Ikbkb Syk Pik3r1 Stat3 Grb2 Nfkbia Chuk Mapk1 Mapk14 Ptpn6 Psma5 Mapk3 Afp Ccl11 Cd4 Akt1 Ccl12 Ccl2 Ccr5 Ptk2b IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha Foxo1 Stat5a Stat1 Rps6kb1 Vav1 Rps6 Crk Stat3 Eif4b Stat5b Map2k6 Nfkbia Crkl Map2k3 Akt1 Irs1 Stat6 Erbb3 Stat4 Irs2 Pla2g4a Ifnar1 Jak1 Eif4ebp1 Arhgap30 Cbl Prkcq Mtor Map2k4 Prkcd Rps6ka5 Zap70 Stat2 TRAIL%IOB%TRAIL TRAIL Dap3 Bex3 Ripk1 Rela Chek2 Casp1 Ikbkg Tnfrsf11b Prkaa1 Tradd Nfkb1 Diablo Bak1 Bcl10 Bax Mcl1 Csnk2a1 Cycs Parp1 Vdac1 Traf2 Tnfsf10 Apaf1 Irf5 Atm Xiap Nfkbia Fadd Mapk1 Mapk14 Ctnnb1 Aifm1 Map3k7 Mapk3 Prkdc Akt1 Creb1 Cflar Tnfrsf10b Bid Casp8 Casp7 Cbl Casp3 Ctsb H2ax Src Casp2 NOTCH%IOB%NOTCH Notch App Fhl1 Hivep3 Lef1 Hdac2 Mfng Numb Ccn3 Skp2 Hes6 Tle1 Maml3 Notch4 Psenen Notch1 Notch2 Notch3 Psen1 Pofut1 Psen2 Ncstn Mapk1 Aph1b Ncor2 Dll1 Dll3 Dll4 Itch Maml1 Ring1 Mapk3 Maml2 Furin Hes1 Jag2 Jag1 Skp1 Cirsr Yy1 Lfng Tcf3 Rbx1 Gsk3b Smad1 Rela Nfkb1 Jak2 Stat3 Smad3 Snw1 Smad4 Cul1 Hdac1 M-CSF%IOB%M-CSF M-CSF Ripk1 Stat5a Vim Ptpn11 Pik3r1 Stat3 Grb2 Stat5b Fadd Mitf Ptk2 Akt1 Shc1 Ets2 Casp8 Csf1r Ptk2b Inpp5d Inppl1 Grap2 Tfe3 Cbl Pstpip2 Dnm1 Prkcd Csf1 EGFR1%IOB%EGFR1 EGFR1 Mapk8 Mapk1 Mapk3 Myc Akt1 Tp53 Prkcg Prkcb Hgs Prkcd Jund Pxn Dab2 Sp1 Jun Cav1 Ptk2 Stk11 Smad2 Smad3 Cdk2 Cdk1 Rhoa Tgif1 Hdac1 Zfyve16 Foxo1 Fos Pik3r1 Crk Pik3r2 Bcar1 Ap2b1 Mapk14 Map2k3 Mapk9 Shc1 Plcg1 Irs2 Ptk2b Elk1 Gsk3b Raf1 Src Rela Nfkb1 Stat1 Rps6kb1 Ptpn11 Jak2 Egfr Khdrbs1 Stat3 Grb2 Map2k1 Stat5b Gab1 Socs1 Crkl Cltc Sh3kbp1 Cblb Dok1 Rps6ka1 Kit Prkca Sos1 Rasa1 Eif4ebp1 Cbl Mtor Abl1 Fyn Lyn Stat5a Hras Cfl1 Ctbp1 Cdh1 Ywhab Rac1 Gsk3a Arhgef4 Jup Nedd4 Plec Lck Anxa4 Met Cd59b Ptpn6 Casp9 Ripk1 Map2k2 Bcl2 Pkn2 Vim Erbb2 Dsp Itgb4 Ywhaz Pik3r3 Col17a1 Ephb2 Pak1 Pik3cg Pik3cb Pik3cd Bad Creb1 Prkci Frs2 Grk2 Dyrk1a Stam2 Vav1 Rps6ka2 Pfn1 Stam Nos3 Dok2 Nck1 Erbb3 Jak1 Rps6ka5 Stat2 Prkaa1 App Itch Inppl1 Dnm1 Atf1 Myl12b Il17rd Pard3 Mprip Prkd1 Eno1 Elk4 Eps8 Gja1 Rpl30 Tfg Ralb Otud6b Araf Plcg2 Arhgap5 Itsn2 Arap1 Zdhhc5 S100a10 Snca Pitpna Flot2 Flot1 Errfi1 Myo6 Scrib Prkcz Tfrc Pik3c2b Antxr1 Arf4 Braf Clta Cyld Ahnak Rplp0 Snx33 Tkt Baiap2l1 Rbck1 Htt Appl2 Caskin2 Stx4 Rps2 Pygb Gsn Pdzd11 Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Abi1 Ensa Frk Hipk2 Hipk3 Map3k14 Eef1a2 Socs3 Grb14 Grb10 Phpt1 Stip1 Map3k4 Pias3 Cdh3 Cdh2 Plekhn1 Tom1 Eps15 Map3k3 Map3k2 Magi1 Map3k1 Hat1 Pkp2 Hnrnpdl Ldlr Pkp3 Flnb Anxa2 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Abl2 Prp4k Slc38a2 Ptpre Tnk2 Ptpra Cdk5 Alb Pdlim1 Sh3bgrl Nck2 Slc12a7 Acp1 Mt-co2 Sh3gl3 Adam9 Epha1 Epha2 Epha4 Itgb1 Pkm Dsg2 Sh3gl2 Ctnnal1 Wbp2 Atp1a1 Ephb1 Cebpb Cebpa Ephb3 Ptpn1 Slitrk6 Csk Arhgap32 Arhgap35 Rbbp7 Tagln2 Pten Ralbp1 Bcar3 Slc25a5 Spart Nectin1 Rps10 Ppp2r3a Prkaa2 Scamp3 Tns4 Tns2 Tns1 Krt8 Cblc Krt7 Phlpp1 Actb Actr2 Actr3 Tln1 Rin1 Vasp Arhgef7 Arhgef5 Hnrnpr Sdc4 Insr Sdc3 Atp5f1c Usp6nl Pttg1ip Slc5a5 Snx5 Tollip Ptk6 Kirrel1 Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Dyrk1b Dcbld2 Ptprf Git1 Vav3 Cdv3 Laptm4a Plekha6 Anks1a Vav2 Mink1 Actn1 Actn4 Plscr1 Gprc5a Aldoa Map2k7 Map2k5 Limd1 Cstb Git2 Krt18 Krt17 Racgap1 Cttn Mpzl1 Axl Ctnnd1 Nedd9 Tjp2 Cavin1 Cavin2 Sdcbp Cc2d1a C8h11orf52 Prkx Ap2a1 Vcl Cysrt1 Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Efnb2 Cav2 Sirpa Ralgds Dlg3 Crim1 Ddx6 S100a11l1 Peak1 Afap1l2 Ddx3x Rbm3 Sfpq Pdpk1 Dapp1 Asap1 Iqgap1 Baiap2 Lsr Epn2 Epn1 Rps6ka3 Dyrk4 Epn3 Usp31 Dyrk3 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Trim29 Eif4g1 Dock1 Phldb2 Ptpn18 Rgs16 Ptpn12 Mta2 Snrpd2 Egf Spry2 Spry1 Reps2 Prag1 Spry4 Pebp1 Ptpn23 Hspe1 Zpr1 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor Ppp1ca Ccne1 Ncor2 Ctnnb1 Akt1 Cdc25a Tcf4 Prkd1 Pxn Brinp1 Nr2c2 Nr2c1 Nrip1 Parp1 Ahr Ar Hsp90aa1 Uxt Pias4 Ube2i Kat5 Kat7 Gtf2f2 Sp1 Gtf2f1 Pias1 Sf1 Ccnh Prdx1 Jun Tle5 Dapk3 Flna Ccnd1 Cdc37 Cav1 Pa2g4 Senp1 Esr1 Top1 Cdc25b Nono Bag1 Gtf2h1 Hspa8 Rbak Psmc3ip Ccnd3 Pelp1 Smad3 Cdk9 Xrcc6 Cdk7 Smad4 Hspa5 Xrcc5 Mdm2 Fhl2 Gsn Pou2f1 Hspb1 Prmt1 Calr Nr0b2 Spdef Daxx Etv5 Lpxn Svil Casp8 Ddc Il6st Casp7 Tgif1 Tmf1 Arnt Hsp90b1 Zmiz2 Hdac1 Zmiz1 Casp3 Rnf4 Foxa1 Magea13 Ncoa2 Pias3 Ncoa4 Nsd2 Casp1 Ncoa6 Nsd1 Pak6 Pnrc1 Cox5b Tgfb1i1 Slc25a4 Vip Rchy1 Ran Pik3r1 Ncoa1 Runx2 Rb1 Brca1 Cebpa Gsk3b Pten Src Rela Rack1 Egfr Stat3 Park7 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 Atf2 Lyn Stat5a Mapk1 Cblb Mapk3 Gab2 Creb1 Akt1 Cebpa Stat3 Jun Cbl Gab1 Atf1 CD40%IOB%CD40 CD40 Lyn Mapk8 Mapk14 Mapk1 Ikbkb Fgr Plcg2 Mapk3 Syk Myc Jak3 Akt1 Pik3r1 Mapk9 Stat3 Jun Map2k1 Lck Nfkbia Fyn Chuk TNFSF3%IOB%TNFSF3 TNFSF3 Nfkb2 Lta Rela Ltb Traf3 Ltbr Nfkb1 Jun Nfkbia Traf2 Tnfrsf1b Tnfrsf1a ID%IOB%ID ID Atf3 Rb1 Elk4 Smad3 Rbl2 Rbl1 Cdk2 Hes1 Myod1 Tcf3 Psmd4 Tcf7l2 Elk3 Elk1 Id2 Id1 Id4 Id3 Myf5 G-CSF%IOB%G-CSF G-CSF Lyn Stat5a Stat1 Ptpn11 Syk Gab2 Jak2 Stat3 Grb2 Stat5b Lck Il3ra Csf3r Pom121 Fth1 Pla2g1b Csnk1e Syp Sod1 Rel Mapk1 Mapk14 Cish Cdkn1b Mapk3 Hck Cdk2 Akt1 Rps6ka1 Prkci Shc1 Inpp5d Jak1 Cbl Socs3 EPO%IOB%EPO EPO Foxo1 Stat5a Map2k2 Ptpn11 Syk Jak2 Vav1 Stat3 Jun Map2k1 Stat5b Sh2b2 Gab1 Braf Gsk3a Crkl Mapk1 Hcls1 Nos3 Sgk1 Mapk3 Bad Akt1 Irs2 Mtor Raf1 Epor Rps6ka5 Foxo4 Foxo3 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma Stat5a Stat1 Plcg2 Jak2 Crk Egfr Stat3 Mapk8 Crkl Mapk1 Mapk14 Spi1 Ifngr1 Irf1 Irf2 Mapk3 Irf8 Mapk11 Akt1 Stat6 Cebpb Pla2g4a Jak1 Cbl Prkcq Raf1 TNFSF1%IOB%TNFSF1 TNFSF1 Rela Traf3 Ikbkg Nfkb1 Tnfrsf14 Tnfrsf1b Tnfrsf1a Akt1 Nfkb2 Lta Ltbr Jun Nfkbia TNFALPHA%IOB%TNFALPHA TNFalpha Fancd2 Psmd3 Psmd2 Stat5a Ikbkg Elp1 Psmd1 Spag9 Tradd Usp11 Glb1 Smarcc2 Prc1 Smarcc1 Rnf25 Map3k11 Mark2 Lrpprc Mtif2 Ywhab Hdac2 Ddx3x Mapk8 Mapk1 Map3k7 Mapk3 Akt1 Skp1 Ube2d3 Prkcd Ube2d2 Btrc Traf3 Faf1 Rpl30 Brinp1 Nr2c2 Csnk2a1 Traf2 Hsp90aa1 Ube2i Jun Prkcz Cops5 Flna Cdc37 Cav1 Fadd Crebbp Cdk9 Hspb1 Cul1 Cflar Bid Casp8 Casp7 Map3k14 Hdac1 Casp3 Casp2 Ripk1 Map3k3 Map3k2 Map3k1 Pkn1 Tnfrsf1b Tnfrsf1a Nfkb2 Ywhah Ywhae Map2k6 Ywhaz Rel Rb1 Mapk14 Nkiras1 Creb1 Mapk9 Rpl4 Nkiras2 Tbkbp1 Trib3 Map3k8 Rps11 Tnf Fbl Tbk1 Unc5cl Akt2 Dpf2 Kcnq1 Azi2 Polr1b Polr1c Src Polr1a Usp2 Rela Fbxw11 Polr1e Tank Gtf2i Hsp90ab1 Nfkb1 Actl6a Stat1 Smarce1 Ikbkb Polr2sl1 Tifa Inpp5e Rps6kb1 Rasa3 Ptpn11 Nfkbiz Syk Papola Rack1 Glg1 Bag4 Egfr Ripk3 Cradd G3bp2 Dcaf7 Cops3 Nfkbib Nfkbie Nlrp4 Kpna6 Mcc Kpna3 Nfkbia Kpna2 Bcl3 Gab1 Ccnt1 Tab2 Chuk Traf7 Mcm7 Traf4 Pfdn2 Traf6 Birc2 Tnfrsf8 Ikbke Ywhag Psmd12 Smarcb1 Psmd13 Alpl Rasal2 Dok1 Akap8 Psmb5 Ppp6c Rpl8l1 Fkbp5 Mcm5 Smarca4 Tnip2 Psmc2 Psmc1 Psmc3 Polr2h Pdcd2 Map2k5 Nsmaf Zfand5 Rps6ka5 Trpc4ap Psmd7 Psmd6 Mapkapk2 GDNF%IOB%GDNF GDNF Ptk2 Pxn Map2k2 Rps6ka3 Rps6kb1 Dok1 Ret Th Crk Cdk1 Cdc25c Ptk2b Jun Map2k1 Nfkbia Raf1 Gab1 Bcar1 Fyn Met TNFSF8%IOB%TNFSF8 TNFSF8 Nfkb2 Rela Traf3 Rel Mapk1 Tnfrsf8 Nfkb1 Bcl3 Akt1 CXCR4%IOB%CXCR4 CXCR4 Lyn Map2k2 Cfl1 Pik3r1 Crk Ywhab Pik3r2 Itk Rac1 Cxcr4 Itgb2 Icam1 Gnai1 Tff2 Lcp2 Cxcl12 Gna13 Grk6 Bcar1 Fyb1 Ackr3 Vcam1 Limk1 Arrb2 Usp14 Mapk1 Map2k3 Mapk3 Bad Creb1 Plcg1 Ptk2b Elk1 Gsk3b Prkcd Zap70 Atf1 Src Rela Pxn Nfkb1 Stat1 Ikbkb Rps6kb1 Plcg2 Ptpn11 Jak3 Jak2 Vav1 Rps6 Egfr Rps6ka2 Stat3 Sdc4 Ptprc Map2k1 Lck Stat5b Nfkbia Chuk Ptk2 Hspa8 Crkl Cblb Ptpn6 Nck1 Dok1 Vav2 Ccr5 Stat4 Rhoa Inpp5d Rasa1 Cbl Stat2 Fyn Foxo3 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Il4 Cabin1 Pou2f1 Ifng Cd40lg Akap5 Faslg Csf2 Junb Nfatc3 Nfatc2 Ptgs2 Fosl1 Jun Chp1 Rcan2 Fkbp1a Il2ra Prkaca Fos Batf3 Il2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Tfe3 Dcp1a Rbl1 Foxh1 Irf7 Gata3 Serpine1 Skil Med15 Atf3 Dlx1 Nr3c1 Myod1 Max Snip1 Cebpb Ar Ncoa2 Ncoa1 Il5 Sp1 Gsc Sap18 Cited1 Sp3 Runx3 Runx1 Runx2 Kat2a Cbfb Vdr Rbbp7 Esr1 Hspa8 Crebbp Smad2 Smad3 Mef2c Smad4 Zbtb17 Cdk4 Cdk2 Lamc1 Tcf3 Cdkn1a E2f5 Smad7 Jun Fos Atf2 Il10 Hnf4a Nkx2-5 Pias3 Tgif1 Hdac2 Pias4 Ifnb1 Ctbp1 Myc Hdac1 Foxg1 Akt1 Foxo4 Cdkn2b Foxo3 Foxo1 Creb1 Col1a2 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Il24 Il17f Il23a Il17a Nfkbia Rela Stat5a Il18r1 Il1b Stat3 Stat1 Pik3r1 Alox12b Il2 Ifng Socs3 Stat4 Il18 Il12b Il19 Cd3e Tnf Il6 Cd4 Ccl12 Cxcl9 Itga3 Il23r Nfkb1 Jak2 Cxcl3 Nos2 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Ube2i Mdm2 Ran Pias1 Pias2 Hdac1 Ranbp2 Xpo1 Hdac4 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Nfkbia Rela Pik3r1 Mapk8 Mapk1 Ilk Jun Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Fos Cd44 Vav3 Gsn Syk Mmp2 Ptk2b Mmp9 Map3k1 Plau Rock2 Chuk Map3k14 Nfkb1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Mapk1 Mapk3 Fkbp1a Smad4 Tgfb1 Tgfb3 Acvrl1 Id1 Arrb2 Smad7 Ppp1ca Csnk2b Cav1 Gdf2 Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Acvr2a Inhba Acvr2b Smad5 Tgfbr1 Tgfbr2 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Shank3 Shc1 Rasa1 Irs1 Src Pxn Irs2 Grb10 Pdlim7 Gdnf Ptpn11 Gfra1 Pik3r1 Nck1 Rap1a Gab1 Frs2 Ptk2 Dok1 Dok4 Dok6 Grb2 Mapk8 Prkca Mapk1 Sos1 Jun Crk Hras Mapk3 Rhoa Bcar1 Prkaca Rac1 Ret Creb1 Grb7 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Mapk1 Col11a1 Mapk3 Col11a2 Fgf19 Cask Prkaca Ccl5 Bsg Hpse Ppib Col2a1 Sdcbp Col3a1 Col1a1 Mmp9 Mmp7 Col4a3 Col5a2 Col6a2 Mmp1 Tgfb1 Col4a1 Hgf Col5a1 Col4a5 Fgf23 Fgfr3 Fgfr4 Lama5 Sdc1 Met Col1a2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Nras Prkcb Rasa1 Rras Prkce Rasgrp3 Rasgrp4 Rasgrp1 Rasgrp2 Rin1 Grb2 Prkca Sos1 Hras Rasa2 Rabgef1 Camk2b Nf1 Rasal1 Dab2ip Kras Prkcz Plce1 Lgals1 Lgals3 Rasgrf2 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Incenp Aurkc Aurkb IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Shc1 Irs1 Irs2 Cebpb Il5 Sp1 Grb2 Col1a1 Socs3 Jak2 Stat5a Pik3r1 Socs1 Spi1 Stat6 Alox15 Socs5 Ets1 Jak3 Aicda Jak1 Fcer2 Il13ra1 Il13ra2 Arg1 Bcl2l1 Mybl1 Dok2 Irf4 Oprm1 Tff3 Lta Inpp5d Il4 Ptpn6 Thy1 Cbl Cd40lg Ccl17 Mtor Selp Ccl11 Rps6kb1 Pigr Egr2 Parp14 Mapk14 Il10 Il4r Il2rg Stat5b Bcl6 Fes Hmga1 Retnlg Akt1 Col1a2 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Shc1 Rela Ptpn11 Pik3r1 Jak3 Jak1 Grb2 Sos1 Bcl2l1 Il2ra Rac1 Il2 Mtor Rps6kb1 Il2rg Smpd1 Eif3a Hsp90aa1 Myc Sgms1 Rps6 Akt1 Gab2 Tert Prkcz Lck Nfkb1 Foxo3 Bcl2 E2f1 Ugcg SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Afdn Angpt1 Shc1 Lmo4 Irs1 Ngf Frs3 Egfr Gnai1 Raf1 Gnai3 Il6st Sdc2 Ptpn11 Ntf4 Ntf3 Pdgfrb Gab1 Ifngr1 Frs2 Vegfa Pdgfb Il6r Arhgap35 Nos3 Egf Grb2 Igf1 Sos1 Ntrk2 Map2k2 Ntrk1 Hras Map2k1 Ntrk3 Tek Igf1r Il6 Kras Jak2 Nras Stat1 Pik3r1 Jak3 Jak1 Rhoa Il2ra Prkaca Il2 Ifng Il2rg Gab2 Lck Bdnf NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Stat3 Myod1 Ar Ncoa1 Runx2 Neurog3 Ncor2 Bglap Arnt Ptf1a Ghr Crebbp Camk2d Hif1a Hey2 Maml1 Maml2 Parp1 Hes1 Twist1 Ascl1 Tcf3 Rb1 Hes6 Tle1 Gaa Kdm1a Rbbp8 Yy1 Notch1 Gata6 Ctbp1 Gata4 Gata1 Cd4 Hdac1 Cdkn1b Jak2 E2f1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itgb7 Itga6 Itga9 Itgb1 Itga2b Itgam Itgb4 Itga4 Itga1 Itgb2 Itga2 Itgal Itga10 Itgav Itgad Itgb8 Itga3 Itga7 Itga8 Itgax Itgb6 Itga5 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Incenp Golga2 Nudc Bora Kif2a Kif20a Fbxo5 Spc24 Ercc6l Fzr1 Pak1 Ppp1r12a Ect2 Bub1 Tubg1 Rhoa Cdc14b Cdc20 Ppp2ca Ppp1cb Ccnb1 Plk1 Gorasp1 Clspn Fbxw11 Stag2 Cenpu Tpx2 Sgo1 Rab1a Rock2 Ppp2r1a Wee1 Prc1 Cdk1 Btrc Ninl Kiz Cdc25c Tpt1 Aurka Cdc25b Ndc80 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Rad50 Fancd2 Pcna Ewsr1 Topbp1 Xrcc6 Brca1 Ube2d3 Xrcc5 Atm Atr Ube2l3 Cdk2 Rbbp8 Ccne1 Cstf1 Bard1 Mre11 Fancl Prkdc Fancc Nbn Tp53 Fancf Fancg Rad51 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway S1pr5 Gnai1 Gnai3 Rhoa Gna12 Gnaz Gnao1 Gnai2 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Nras Shc1 Ngf Src Stat5a Pik3r1 Gab1 Camk4 Ywhah Ywhag Ywhae Grb2 Epb41l1 Pdpk1 Sos1 Camk2a Ywhab Ntrk1 Hras Trpc3 Trpv1 Sfn Egr1 Bad Ccnd1 Plcg1 Gsk3b Prkcd Ywhaz Akt1 Kras Foxo3 Creb1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Il18r1 Stat3 Pias2 Mapk8 Jun Il2ra Fos Il2 Crebbp Mapk9 Ifng Il13 Cd3g Cd247 Prf1 Cd3d Cd28 Tgfb1 RT1-Da Cd86 Cd80 Tbx21 RT1-Db1 Etv5 Stat4 Irf1 Il18 Cd3e Cd4 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Ncapd2 Septin1 Rasa1 Tacc1 Mylk Des Nsun2 Pebp1 Cul3 Klhl13 Incenp Vim Kif23 Aurkc Aurkb Kif20a Bub1 Rhoa Sgo1 Psma3 Aurka Cenpa Klhl9 Ndc80 Stmn1 Kif2c Ppp2r5d Smc4 Smc2 Ncapg Ncaph Ppp1cc Cbx5 Npm1 Cdca8 Racgap1 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Src Pitpna Pik3r1 Ntn1 Nck1 Dock1 Elmo1 Fyn Yes1 Ptk2 Trio Dcc Map1b Dapk1 Pak1 Unc5b Mapk1 Myo10 Camk2a Map2k2 Unc5a Unc5c Mapk3 Map2k1 Rhoa Bcar1 Rac1 Plcg1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Gnai1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Mapk1 Gna13 Mapk3 Rhoa S1pr4 Plcg1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Mapk1 Map2k1 Pde3b Pik3r6 Pik3cg C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Ppp3ca Kitlg Cbx4 Casp6 Anpep Gata3 Mad1l1 Ca1 Zfhx3 Cdk6 Lect2 Myf6 Tab2 Myod1 Hipk2 Ada Cebpb Sp1 Hras Ccnd1 Hspa8 Crebbp Hes1 Cdkn1a Gata1 Cd4 Cdkn1b Kras Nras Spi1 Ube2i Ets1 Adora2b Ccnb1 Ccna1 Slc25a3 Birc3 Prtn3 Map3k7 Ets2 Clta Tfec Pim1 Tom1 Iqgap1 Cdkn2a Rag2 Ptgs2 Ppidl1 Atp2b1 Snd1 Maf Pias3 Ptcra Kit Smarca2 Mcm4 Cd34 Lef1 Myc Mat2a Trim28 Nlk Cebpa Elane Csf1r Gstm2 Bcl2 Yeats4 Wnt1 Col1a2 H2az1 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Nras Shc1 Rasa1 Rras Src Pxn Pik3r1 Nck1 Rap1a Ephb1 Ephb2 Ephb3 Ptk2 Tf Efnb1 Efnb2 Efnb3 Grb2 Pak1 Rap1b Mapk1 Synj1 Dnm1 Crk Itsn1 Hras Mapk3 Map2k1 Rock1 Kalrn Efna5 Rac1 Kras Grb7 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Src Pik3r1 Mapk8 Pdpk1 Ikbkb Birc2 Ikbkg Map2k7 Map2k6 Birc3 Cltc Syk Cflar Mapk9 Faim2 Bid Pik3cb Map3k1 Casp8 Faslg Rfc1 Casp3 Chuk Ripk1 Btk Fas Mapk14 Fadd Ezr Mapk10 Mapk11 Smpd1 Akt1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Cycs Eif2a Map2k4 Sphk2 Nfkbia Bax Rela Raf1 Egf Mapk8 Igf1 Mapk1 Map2k2 Mapk3 Map2k1 Bad Birc3 Prkcd Bid Map3k1 Casp8 Ripk1 Rb1 Fadd Smpd3 Ctsd Smpd1 Aifm1 Eif2ak2 Tnf Pawr Myc Nsmaf Madd Asah1 Akt1 Tnfrsf1a Bag4 Prkcz Cradd Nfkb1 Bcl2 Pdgfa Traf2 Prkra ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Src Blk Csnk2a1 Pld1 Plcb2 Klk6 Pld2 Th Ube2l3 Tor1a Grk5 Sncaip Fyn Slc6a3 Lyn Yes1 Prkn Uchl1 Maob Fgr Hck Park7 Snca Fkbp1a Bad Syk Prkcd Ptk2b Ppp2r5d Lck ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Syk Src Nfkbia Rela Pik3r1 Mapk14 Btrc Arrb2 Bcl3 Rel Lck Ikbkb Nfkb1 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Map2k4 Itgb1 Pld1 Pld2 Mapk8 Ppp1r12a Jun Rock1 Srf Rhoa Ccn1 Slc9a1 Acta1 Fos Mapk12 Pard6a Map2k6 Diaph1 Slc9a3 Rdx Cfl1 Msn Pten Cit Map2k3 Rock2 Myl2 Limk1 Limk2 Pkn2 Atf2 Pkn1 Sh3gl2 Ezr Tln1 Pip5k1c Pip5k1b F2rl2 Vcl Scai Cdkn1b Prkcz SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Fcgr2a Shc1 Capn1 Spry2 Irs1 Fer Src Lep Egfr Nox4 Lat Lepr Pdgfrb Pdgfb Dok1 Egf Grb2 Crk Socs3 Jak2 Itga2b Blk Stat5a Stat3 Pik3r1 Fyn Lyn Yes1 Fgr Hck Rhoa Bcar1 Stat5b Cav1 Txn1 Ins2 Prl Ybx1 Prlr Cdh2 Akt1 Csn2 Lck Csf1 Csf1r Insr Trpv6 Ptpn1 Csk SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Rasa1 Itgb1 Src Bax Fn1 Kng2l1 Sdc2 Itga2 Cav2 Trappc4 Rack1 Epb41 Lama1 Ephb2 Lama3 Mapk8 Mapk1 Hras Mapk3 Rhoa Fgf19 Cask Prkaca Prkcd Sdcbp Mmp2 Csf2 Casp3 Tgfb1 Ezr Fgf23 Fgfr3 Fgfr4 Nf1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Nras Prkcb Raf1 Ptpn7 Braf Map3k8 Elk1 Prkca Mapk1 Hras Mapk3 Map2k1 Kras Fos ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Brca1 Atf3 Hrk Ccna2 Prkca Serpinb5 Kat5 Macroh2a1 Ddit3 Col24a1 Jdp2 Ruvbl2 Jund Cbfb Csrp2 Ccnd1 Gadd45a Sele Esr1 Dusp5 Tgfb2 Mapk9 Dusp1 Pdgfra Dusp10 Dusp8 Hbg1 Ppargc1a Cdk4 Hes1 Rb1 Socs3 Mapk11 Il6 Nf1 Nos2 Il23a Cul3 Th Mapk8 Mapk1 Jun Arg1 Mapk3 Bcl2l1 Fos Pou2f1 Mmp2 Ifng Plau Junb Atf2 Mapk14 Ins2 Bcl2 Creb1 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Src Blk Fyn Lyn Yes1 Fgr Hck Crk Rock1 Rhoa Efna5 Pik3r6 Pik3cg Vav3 Plcg1 Cbl Efna1 Efna2 Efna3 Arhgef15 Crkl Ngef Epha1 Epha2 Vav2 Epha3 Epha4 Epha6 Epha7 Cdk5 Epha8 Lck SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Max Sap18 Ncor2 Rbbp7 Crebbp Smad7 Yy1 Tnf Gata1 Nr2c1 Hdac3 Prmt5 Tnfrsf1a Hdac7 Nfkb1 Hdac8 Fkbp3 Pparg Chd3 Chd4 Sirt3 Sirt2 Sirt1 Smurf1 Nfkbia Rela Wdr77 Sirt6 Gata2 Sirt5 Sirt4 Stat3 Hdac11 Hdac10 Mta2 Ranbp2 Mbd3 Xpo1 Mbd2 Hdac4 Gatad2a Ube2i Mxd1 Gatad2b Ran Prkaca Btrc Hdac2 Hdac1 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Itga6 Itga9 Itgb1 Pld1 Itga4 Itga1 Pld2 Itga2 Ctnnb1 Klc1 Tshr Cdh1 Agtr1a Slc2a4 Itgav Adrb2 Scamp2 Rala Acap1 Exoc3 Ctnna1 Exoc5 Exoc6 Vamp3 Cltc Nme1 Exoc2 Dnm2 Avpr2 Spag9 Exoc7 Bin1 Ctnnd1 Mapk8ip3 Arf6 Pip5k1c Ins2 Itga10 Itga3 Itga7 Itga8 Itga5 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Sirt1 Xpo1 Ctnnb1 Ywhah Ran Ywhag Ywhae Mapk8 Ywhab Rala Sfn Ikbkb Ccnb1 Gadd45a Plk1 Crebbp Ywhaz Mapk9 Faslg Chuk Cdk2 Csnk1a1 Csnk1g3 Csnk1g1 Bcl2l11 Mapk10 Csnk1g2 Zfand5 Bcl6 Skp2 Fbxo32 Ralb Mst1 Sod2 Usp7 G6pc1 Cdkn1b Rbl2 Akt1 Cat Foxo4 Csnk1d Sgk1 Foxo3 Csnk1e Foxo1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Gna14 Abcc1 Gnaq Sphk2 Sphk1 S1pr1 S1pr3 Gnai1 S1pr2 Sgpp1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Gna13 S1pr4 Gna11 Sgpl1 Gna15 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Src Raf1 Rictor Akt3 Akt2 Casp9 Kpna1 Mapkap1 Gsk3a Mlst8 Ywhah Ywhag Ywhae Pdpk1 Slc2a4 Ywhab Bcl2l1 Sfn Prkaca Bad Gsk3b Ywhaz Mtor Chuk Cdkn1a Hsp90aa1 Cdkn1b Prkdc Akt1 Foxo4 Foxo3 Foxo1 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Afdn Itgb7 Src Pik3r1 Rap1a Tiam1 Enah Ctnnb1 Nckap1 Klhl20 Ap1m1 Cdh1 Wasf2 Rap1b Jup Cttn Crk Tjp1 Dlg1 Rhoa Abi1 Rac1 Ctnna1 Ccnd1 Nme1 Ctnnd1 Iqgap1 Arf6 Pip5k1c Vav2 Akt1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Gli2 Shh Grk2 Tgfb2 Lrpap1 Smo Ptch1 Boc Pthlh Cdon Pik3r1 Arrb2 Akt1 Stil Dhh Hhip Ihh Lrp2 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk4 Plk2 Plk3 Plk1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Nckap1 Wasf2 Crk Abi1 Map2k7 Map2k6 Mapk9 Ncf1 Ncf2 Brk1 Arhgdia Noxa1 Baiap2 Iqgap3 Arpc1b Actr2 Actr3 Arhgap5 Pak2 Wasf1 Arpc3 Noxo1 Arpc2 Cyba Abi2 Cybb Arpc5 Arpc4 Racgap1 Map3k11 Map2k4 Stat5a Plcb2 Stat3 Ctnnb1 Mapk8 Cdh1 Pak1 Jun Bcar1 Rac1 Ctnna1 Cfl1 Map3k1 Map2k3 Iqgap1 Limk1 Atf2 Mapk14 Pip5k1c Pip5k1b VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Gngt2 Gnat2 Rdh12 Slc24a2 Rgs9bp Pde6c Cnga3 Arr3 Cngb3 Grk1 Gucy2e Rpe65 Pde6h Gnb3 Guca1b Gnb5 Guca1a Rgs9 Lrat Gucy2f REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Arhgef7 Mcf2l Arhgef6 Spata13 Fgd1 Itsn1 Arhgef9 Git1 Dnmbp Mcf2 Arhgap17 Dock11 Vav3 Plcg1 Ralbp1 Bcar3 Nme1 Arhgef25 Farp2 Dock6 Arhgap1 Apc Itsn2 Arhgdia Ngef Vav2 Racgap1 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Sirt1 Serpine1 Vegfa Ets1 Elk1 Sp1 Arnt Crebbp Adora2a Flt1 Efna1 Epo Eif3e Twist1 Bhlhe40 Hif1an Egln2 Egln3 Epas1 Cited2 Pgk1 Slc2a1 Vhl Pou5f1 Slc11a2 Mmp14 Apex1 Abcg2 Eloc Fxn REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Trim24 Appbp2 Pde9a Map2k4 Kat7 Sirt1 Src Nr0b1 Spdef Rxrb Rxra Gata2 Smarce1 Ehmt2 Smarcc1 Nr3c1 Rxrg Rack1 Senp1 Tmprss2 Rchy1 Ar Ncoa2 Mdm2 Ncoa1 Mapk8 Kat5 Jun Rel Egr1 Map2k6 Gsk3b Pou2f1 Crebbp Mapk14 Pkn1 Smarca2 Hsp90aa1 Hdac1 Nr2c1 Cebpa Nr2c2 Hdac7 Hoxb13 Carm1 Foxo1 Dnaja1 Zmiz2 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Shc1 Pdgfra Csnk2a1 Pik3r1 Crkl Cav3 Shf Cav1 Elk1 Grb2 Jak1 Sos1 Jun Crk Itgav Srf Fos Plcg1 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Src Egfr Fgf23 Fgfr3 Fyn Fgfr4 Ncstn Aph1b Ncan Sdc3 Ptn Mc4r Cttn Psenen Pomc Psen1 Agrp Fgf19 Cask SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Cebpb Jun Ddit3 Atf1 Gdi1 Slc9a1 Eif4ebp1 Pla2g4a Mitf Rab5a Esr1 Elk4 Hspb1 Usf1 Mapkapk3 Krt8 Mef2c Eif4e Mapkapk5 Ppargc1a Rps6ka5 Hbp1 Mknk1 Atf6 Ptgs2 Atf2 Mapk14 Mapk11 Tp53 Creb1 Nos2 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Itgb1 Src Pxn Itga4 Fn1 Dock1 Ptk2 Crk Git1 Abi1 Bcar1 Spp1 Prkaca Rac1 Ywhaz Ptk2b Arf6 Prkar1b Mdk Jaml Tln1 Jam2 Cd81 Ptpra Prkacb Adam28 Myh2 Vcam1 Igsf8 Cd14 Thbs2 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Wnt3a Wnt7a Wnt2 Wnt3 Fzd1 Cthrc1 Fzd2 Kremen2 Fzd5 Fzd4 Ryk Fzd6 Kremen1 Fzd9 Rspo1 Fzd8 Dkk1 Ror2 Atp6ap2 Lrp6 Lrp5 Igfbp4 Wnt5a Wif1 Wnt1 Wnt7b AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Atf3 Nr3c1 Il5 Sp1 Egr1 Jund Cbfb Ccnd1 Esr1 Dusp1 Hif1a Mmp1 Il6 Cdkn1b Ccl12 Gata2 Th Ets1 Dmp1 Ctnnb1 Gja1 Edn1 Elf1 Penk Fosl1 Dmtf1 Jun Mt2 Nts Mafg Ccn1 Bag1 Tcf7l2 Acta1 Fos Cops5 Fabp4 Il2 Timp1 Il4 Agt Nppa Ifng Mmp9 Pten Plau Csf2 Junb Nfatc3 Cdkn2a Nfatc2 Tgfb1 Cdk1 Atf2 Il10 Bcl2l11 Maf Myc Tp53 Creb1 Col1a2 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Sdcbp Csf2rb Il5ra Cish Stat5a Pim1 Ptpn11 Pik3r1 Stat5b Lyn Il5 Grb2 Jak2 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Pxn Rictor Xpo1 Ctnnb1 Arhgef7 Arhgef6 Ppp1r12a Ilk Jun Ruvbl2 Rac1 Ccnd1 Diaph1 Gsk3b Ilkap Ruvbl1 Rhog Ppp1r14a Parp1 Ppp1r14c Iqgap1 Ppp1r14b Naca Elmo2 Nck2 Tns1 Git2 Parvg Tacc3 Aurka Snai1 Lims2 Zeb1 Actn1 Hsp90aa1 Parvb Zyx Cdc37 Akt1 Parva Ckap5 Myl9 Creb1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Gap43 Kif5b Cnr1 Fgfr1 Fer Gria2 Dagla Axin1 Ptpn11 Pik3r1 Ctnnb1 Gja1 Mapk8 Jup Cttn Rock1 Rhoa Rac1 Ctnna1 Plcg1 Gsn Ctnnd1 Myl2 Pip5k1c Cdh2 Lrp5 Daglb Camk2g Mapre1 Ptpn1 Dctn1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Rxrb Fam120b Rxra Rara Med1 Rarg Thrb Rxrg Thra Nr1h4 Nr1h3 Nr1h2 Ppard Ppara Ncoa1 Abca1 Srebf1 Nr4a1 Ncor2 Vdr Rps6kb1 Tgfb1 Tnf Bcl2 Pparg P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Tp63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Lmo4 Pcna Nr0b1 Brca1 Med1 Cebpb Ncoa2 Ncoa1 Col18a1 Mpg Nrip1 Sra1 Ube2m Apbb1 Ebag9 Safb Phb2 Ncor2 Ccnd1 Pdia2 Anp32a Esr1 Ap1b1 Pou4f1 Lcor Pou4f2 Nr0b2 Cd82 Smad4 Dscam Pgr Axin2 Tff1 Setsip Ncoa7 Atp5pf C3 Mta1 Hsf2 Xbp1 Sod1 Ctsd Esr2 Ndufv3 Abca3 Prdm15 Calcoco1 Uba3 Nedd8 Stat5a Hdac4 Jun Chuk Prl Myc Hdac1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Angpt1 Shc1 Rasa1 Pxn Fn1 Ptpn11 Nck1 Ptk2 Elk1 Nos3 Grb2 Crk Tek Cdkn1a Tnf Grb14 Fgf2 Nfkb1 Angpt2 Angpt4 F2 Elf2 Itga5 Tnip2 Plg Bmx Itgb1 Rela Stat5a Pld2 Pik3r1 Fyn Ets1 Mapk8 Elf1 Pak1 Mapk1 Agtr1a Mapk3 Dok2 Rac1 Mmp2 Rps6kb1 Mapk14 Stat5b Fes Akt1 Foxo1 Grb7 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Nras Prkcb Tnfrsf4 Prkce Ifnar1 Eomes Egr4 Prkcq Raf1 Tnfrsf9 Cd8b Cd8a Ifna1l1 B2m Ptpn7 Braf Elk1 Mapk8 Prkca Mapk1 Fosl1 Jun Map2k2 Hras Mapk3 Map2k1 Il2ra Egr1 Fos Il2 Mapk9 Ifng Cd3g Cd247 Faslg Prf1 Cd3d Junb Nfatc3 Nfatc2 Il2rg Stat4 Cd3e Tnf Kras SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Rasa1 Src Pxn Raf1 Nck1 Rap1a Ptk2 Braf Arhgap35 Grb2 Rap1b Sos1 Crk Map2k1 Ccnd1 Plcg1 Mapk9 Itga5 Rras Bmx Map2k4 Itgb1 Pik3r1 Arhgef11 Dock1 Asap1 Elmo1 Arhgef28 Fyn Arhgap26 Yes1 Ets1 Capn2 Ptpn21 Arhgef7 Mapk8 Pak1 Mapk1 Jun Itgav Rhoa Bcar1 Rac1 Acta1 Rock2 Mapk8ip3 Nck2 Tln1 Git2 Vcl Actn1 Grb7 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Lama5 Itga6 Lamb2 Lamb3 Lama2 Itgb4 Lamb1 Lamc1 Lama1 Lama3 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Rad50 Fancd2 Topbp1 Brca1 Atm Atr H2ax Ube2t Blm Chek1 Wdr48 Usp1 Fancb Palb2 Rfc5 Rfc3 Faap100 Rfc4 Fbxw11 Rfc2 Rmi1 Hus1 Rpa2 Rad17 Atrip Hes1 Brip1 Brca2 Rad1 Faap24 Btrc Fan1 Mre11 Fancl Fancc Nbn Fancf Fancg VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Adrm1 Il1a Axl Perp Top2a Atm Rack1 Ada Mdm2 Tp63 Runx1 Sfn Vdr Gsk3b Hes1 Hbp1 Cdkn2a Brca2 Col5a1 Dlx5 Dlx6 Bdkrb2 Ppp2r5a Igfbp3 Hells Notch1 Sec14l2 Itch Stxbp4 Mre11 Tcf7l1 Ccnb2 Gpx2 Itga3 Rrad Krt14 Wwp1 Rab38 Nrg1 Tbxt CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Casp6 App Arhgdib Slk Cfl2 Xiap Sptan1 Lmna Casp9 Apaf1 Gas2 Top1 Tfap2a Numa1 Ptk2 Lmnb1 Lmnb2 Pidd1 Srebf1 Casp7 Krt18 Casp4 Satb1 Casp2 Casp1 Diablo Dffa Dffb Birc2 Bid Casp8 Prf1 Parp1 Casp3 Ripk1 Tnf Madd Tnfrsf1a Cradd Traf2 Cycs Bax Vim Acta1 Gsn Birc3 Map3k1 Limk1 Bcl2 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Dock1 Elmo1 Tiam1 Trio Arhgef7 Arhgef6 Sos1 Spata13 Abi1 Kalrn Mcf2 Arhgef2 Rac1 Arhgap17 Dock2 Abr Vav3 Ralbp1 Eps8 Rap1gds1 Arhgef25 Prex1 Prex2 Dock6 Vav1 Arhgap1 Bcr Arhgap9 Arhgdia Ngef Vav2 Racgap1 Rasgrf2 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Plg Itgam Itgb2 Rap1a Rap1b Hck Rock1 Rhoa Thy1 Mmp2 Mmp9 Selp Plau Lrp1 Selplg Ccn2 Jam3 Plat Ager Icam1 Tln1 Mst1r Jam2 Apob Mst1 Myh2 Tnf Il6 Nfkb1 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Nme1 Pld1 Pld2 Arf6 Tiam1 Arf1 Rab11fip3 Rab11a Mapk1 Mapk3 Rhoa Kalrn Rac1 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Shc1 Rasa1 Sphk1 Fer S1pr1 Pxn Lat Raf1 Ptpn11 Ptk2 Dok1 Grb2 Sos1 Map2k2 Hras Map2k1 Ikbkb Ikbkg Pla2g4a Plcg1 Map2k7 Dusp1 Vav1 Btk Itk Fcer1a Plpp1 Pak2 Klrg1 Hcls1 Cblb Wipf1 Lat2 Lcp2 Nfkb1 Ptpn13 Pla2g1b Ms4a2 Fcgr2b Prkcb Map2k4 Rela Pld2 Pik3r1 Fyn Lyn Mapk8 Mapk1 Jun Mapk3 Fos Inpp5d Syk Cbl Map3k1 Chuk Nfatc2 Akt1 Gab2 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Gna14 Cxcr4 Gnaq Src S1pr3 Gnai1 Gnai3 Akt3 Gna12 Pdgfrb Gnaz Gnao1 Vegfa Gnai2 Pdgfb Mapk1 Gna13 Mapk3 Rhoa Rac1 Flt1 Akt1 Gna11 Jak2 Gna15 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Itgb7 Ptk2 Madcam1 Itgb1 Vcam1 Pxn Itga4 Rhoa NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Shc1 Rasa1 Ngf Frs3 Ptpn11 Ntf4 Ntf3 Rap1a Gab1 Frs2 Tiam1 Grb2 Rap1b Sos1 Ntrk2 Dnm1 Crk Ntrk1 Hras Map2k1 Ntrk3 Ccnd1 Plcg1 Crkl Kras Prkcz Nras Matk Sqstm1 Faim Prkci Maged1 Dnaja3 Ngfr Shc3 Stat3 Shc2 Pik3r1 Gipc1 Rgs19 Dock1 Dynlt1 Elmo1 Nedd4l Abl1 Arhgap32 Rit1 Rit2 Ehd4 Mcf2l Mapk1 Mapk3 Rhoa Rac1 Rhog Gab2 Bdnf CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Nras Src Blk Lat Pik3r1 Rap1a Fyn Lyn Yes1 Cyth2 Fgr Zap70 Hck Cyth3 Pdpk1 Cyth1 Dapp1 Hras Inppl1 Rhoa Plekha1 Plcg2 Blnk Pik3r6 Pik3cg Rac1 Adap1 Arf5 Plcg1 Inpp5d Syk Pik3cb Pten Btk Arf6 Arf1 Itk Hsp90aa1 Kras Lck Sgk1 Foxo3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Shc1 Stat5a Tab2 Pik3r1 Fyn Mdm2 Grb2 Mapk1 Mapk3 Wwox Erbb2 Erbb4 Nedd4 Lrig1 Adam17 Ereg Pik3cb Hbegf Nrg2 Btc Cbfa2t3 Nrg4 Nrg3 Dlg4 Grin2b Stat5b Itch Prl Prlr Wwp1 Jak2 Nrg1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Nras Shc1 Stat5a Raf1 Stat3 Ptpn11 Stat1 Pik3r1 Lyn Grb2 Mapk1 Sos1 Map2k2 Hras Mapk3 Map2k1 Ikbkb Prkaca Fos Inpp5d Syk Csf2rb Ywhaz Cish Pim1 Csf2 Osm Stat5b Irf8 Prkacb Ccl12 Gab2 Kras Jak2 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Mapk13 Map2k6 Eef2k Snta1 Stmn1 Map2k3 Pkn1 Mapk12 Ccnd1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Afdn Egfr Nck1 Enah Ctnnb1 Nckap1 Egf Cdh1 Igf1 Rock1 Rhoa Git1 Abi1 Exoc3 Igf1r Ctnna1 Diaph1 Ctnnd1 Myl2 Efna1 Arf6 Hgf Pip5k1c Epha2 Vcl Lima1 Met Vasp Aqp5 Actn1 Kifc3 Mgat3 Zyx Aqp3 Lpp Nectin2 Myo6 Stx4 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Camkk2 Akap1 Sh2d2a Hsp90ab1 Hgs Src Pxn Ptpn2 Vtn Grb10 Raf1 Ptpn11 Nck1 Gab1 Vegfa Ptk2 Braf Nos3 Grb2 Prkca Pdpk1 Map2k2 Map2k1 Rock1 Plcg1 Map2k6 Prkcd Mapk11 Arf1 Pak2 Prkcb Pik3r1 Fyn Ctnnb1 Mapk1 Itgav Mapk3 Rhoa Prkaca Ctnna1 Ptpn6 Nedd4 Fbxw11 Dnm2 Cbl Ptk2b Map2k3 Flt1 Iqgap1 Mapk14 Nck2 Cav1 Fes Vcl Hsp90aa1 Akt1 Myof Cdh5 Ptprj VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Riox2 Eno1 Bmi1 Ndufaf2 Bcat1 Ddx18 Shmt1 Max Hspd1 Prdx3 Cad Nme2 Mtdh Actl6a Cdc25a Serpini1 Odc1 Kat5 Taf9 Eif4g1 Gpam Rpl11 Id2 Ruvbl2 Eif2s1 Kat2a Supt7l Pfkm Lin28b Myct1 Ccnd2 Tfrc Crebbp Pdcd10 Smad3 Hspa4 Ireb2 Eif4e Smad4 Eif4a1 Ubtf Cdk4 E2f3 Mta1 Npm1 Bax Fosl1 Ccnb1 Nme1 Mmp9 Ruvbl1 Pim1 Slc2a1 Snai1 Hmga1 Hsp90aa1 Myc Tert Nbn Tp53 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Map2k4 Src Blk Fyn Lyn Yes1 Fgr Pak1 Hck Rala Rac1 Map2k6 Dusp1 Dusp10 Dusp8 Map2k3 Dusp16 Ripk1 Traf6 Pak3 Mapk14 Map3k3 Map3k12 Mapk11 Ralb Pak2 Lck SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Shc1 Kitlg Fer Grb10 Raf1 Ptpn11 Gab1 Dok1 Grb2 Pdpk1 Sos1 Map2k2 Hras Map2k1 Bad Mitf Gsk3b Crebbp Vav1 Crkl Stap1 Ptpro Spred1 Spred2 Epor Grap2 Pik3c2b Sh2b2 Map4k1 Tec Jak2 Matk Stat5a Stat3 Stat1 Pik3r1 Socs1 Lyn Mapk8 Mapk3 Ptpn6 Cbl Pten Rps6kb1 Epo Kit Akt1 Foxo3 Bcl2 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Shh Mapk9 Mapk8 Ptch1 Bmp4 Fgf7 Gpc3 Furin ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Adam8 Sat1 Itga9 Kcnj15 Itgb1 Vegfd Src Vegfc Pxn Paox Tgm2 Csf2 Fn1 Vegfa Vcam1 Bcar1 Adam2 Spp1 Adam12 Rac1 F13a1 Nos2 Adam15 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Xrcc6 Pnkp Polm Xrcc5 Nhej1 Dntt Dclre1c Aptx Lig4 Aplf Xrcc4 Poll Prkdc SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Shc1 Hgs Src Pxn Ptpn2 Raf1 Akt2 Ptpn11 Nck1 Rap1a Gab1 Mlst8 Ptk2 Grb2 Rap1b Pdpk1 Sos1 Crk Map2k2 Hras Map2k1 Egr1 Eif4ebp1 Bad Plcg1 Rab5a Eif4e Hgf Crkl Met Pak2 Prkcz Map2k4 Prkci Pik3r1 Rptor Ets1 Ctnnb1 Kpnb1 Numb Sh3kbp1 Mapk8 Cdh1 Eps15 Pak1 Mapk1 Rin2 Arhgef4 Jun Pak4 Mapk3 Inppl1 Akt1s1 Rhoa Muc20 Bcar1 Ranbp10 Rac1 Ctnna1 Pard6a Inpp5d Cbl Map3k1 Mtor Apc Arf6 Nck2 Sh3gl2 F2rl2 Snai1 Akt1 Gab2 Ptpn1 Ptprj EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Nras Shc1 Rasa1 Src Egfr Gnai1 Gnai3 Stat3 Ptpn11 Stat1 Pik3r1 Nck1 Gab1 Ptk2 Egf Grb2 Pak1 Mapk1 Sos1 Hras Mapk3 Plcg1 Gsn Ptpn6 Pik3cb Nck2 Tln1 Pip5k1c Kras Ptpn1 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Gna14 Prkcb Gnaq Gnai1 Plcb2 Gnai3 Pik3r1 Gna12 Gnaz Gnao1 Gnai2 Nos3 Prkca Dnm1 Gna13 Rock1 Rhoa Plcb3 F2r Arhgef1 Plcb1 Trpc6 Grk3 Prkcd Snx2 Snx1 Dnm2 Arrb1 Prkcg Gnb1 Rock2 Myl2 Pkn1 Arhgdia F2rl2 Vasp Zyx Gna11 F2 Gna15 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Cxcr4 Plg Fgfr1 Itgb1 Fn1 Gipc1 Lama1 Lama3 Ptk2 Prkca Rhoa Ccl5 Rac1 Prkcd Sdcbp Dnm2 Mmp9 Cxcl12 Sdc4 Fgf6 Nudt16l1 Tfpi Mdk Actn1 Fgf2 Adam12 F2 Itga5 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Atm Atr Hipk2 Rchy1 Ccna2 Kat5 Rpl11 Gsk3b Prkcd Crebbp Mapk9 Cdk2 Yy1 Nedd8 Prmt5 Abl1 Mdm2 Mapk8 Chek1 Ppp2ca Cdkn2a Csnk1a1 Smyd2 Csnk1g3 Mapk14 Csnk1g1 Cse1l Kat8 Csnk1g2 Fbxo11 Kmt5a Skp2 Dyrk2 Ptpa Rpl23 Ube2d1 Rassf1 Usp7 Ccng1 Trim28 Chek2 Setd7 Akt1 Rpl5l1 Csnk1d Ttc5 Pin1 Tp53 Csnk1e Mdm4 E4f1 Ppm1d Daxx CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Rnf128 Ctla4 Dgka Slc3a2 Egr3 Gata3 Foxp3 Egr4 Prkcq Il5 Fosl1 Jun Il2ra Egr1 Irf4 Fos Batf3 Il2 Il4 Pou2f1 Ifng Cd40lg Faslg Csf2 Casp3 Cdk4 Junb Nfatc3 Nfatc2 Egr2 Ptgs2 Tbx21 Maf Tnf Itch Cblb E2f1 Ptpn1 Pparg E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Ctnnb1 Cdh1 Jup S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Gna14 Gnaq Irs1 Gnai1 S1pr2 Gnai3 Gna12 Mapk14 Gnaz Gnao1 Gnai2 Elk1 Mapk8 Pak1 Mapk1 Jun Gna13 Mapk3 Rhoa Gna11 Fos Rac1 Cdh5 Gna15 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Src Gnrh1 Gnai1 Shbg Raf1 Plcb2 Pelp1 Gnai3 Pik3r1 Gnaz Gnao1 Gnai2 Ar Ptk2 Mapk1 Map2k2 Hras Mapk3 Map2k1 Plcg2 Plcb3 Rac1 Fos Plcb1 Plcg1 Gnb1 Akt1 Creb1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Ccne1 Chek2 Plk3 Tp53 Cdc25c VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Itgb4 Hmox1 Txlng Usf2 Lif Dcn Thbd Lama3 Mgp Atf4 Gja1 Nos3 Sp1 Ccna2 Fosl1 Dmtf1 Jun Jund Ccnd1 Bglap Mmp2 Mmp9 Plau Junb Nfatc3 Mmp1 Cdkn2a Nfatc2 Il6 Ccl12 Col1a2 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Rad50 Fancd2 Brca1 Atm Dclre1c Abl1 Xrcc4 Terf2 Mdm2 Tp53bp1 ABRAXAS1 Smc3 Cdc25a Ube2n Uimc1 H2ax Kat5 Smc1a Ywhab Blm Bid Rad17 Cdc25c Rbbp8 Ctbp1 Trim28 Chek2 Mre11 Nbn HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Cycs Casp6 Nfkbia Rela Casp9 Apaf1 Casp7 Mapk8 Casp2 Map2k7 Birc3 Cflar Bid Cd247 Casp8 Faslg Casp3 Chuk Ripk1 Map3k14 Fas Fadd Tnf Tnfrsf1a Bag4 Cradd Nfkb1 Bcl2 Traf2 Daxx ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling S100a9 Tirap Tlr4 S100a8 Tlr3 Tlr2 Chuk Hspd1 Cd14 Irak2 Irak1 Bgn Rhoa Sftpa1 Ikbkb Myd88 Vcan Ikbkg Irak4 Tlr6 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Il17a Ifng Gata3 Il12rb2 Stat5a Ebi3 Il27 Il1b Il6st Il12a Stat3 Tgfb1 Stat2 Stat1 Tbx21 Stat4 Il18 Il12b Jak1 Tnf Il6 Jak2 Il2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Shc1 Ngf Casp6 App Xiap Ntf4 Casp9 Apaf1 Ntf3 Ncstn Aph1b Ywhae Psenen Ntrk1 Psen1 Irak1 Diablo Ikbkb Myd88 Birc2 Bad Ikbkg Mapk9 Mmp7 Casp3 Traf6 Zfp110 Rhoc Arhgdia Rhob Lingo1 Mapk10 Mmp3 Omg Mag Prkacb Mageh1 Smpd2 Bex3 Bex1 Nsmce3 Rtn4 Ripk2 Ndn Prdm4 Furin Prkcz Sort1 Cycs Plg Sqstm1 Prkci Maged1 Ngfr Pik3r1 Mapk8 Rhoa Rac1 Birc3 Adam17 Chuk Bcl2l11 Akt1 Tp53 E2f1 Bdnf CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Gsk3b Wnt3a Dvl3 Pi4k2a Apc Axin1 Cul3 Fzd5 Csnk1g1 Gsk3a Pip5k1b Cav1 Ppp2r5a Ctnnb1 Lrp6 Nkd2 Ranbp3 Dvl1 Klhl12 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Shc1 Il17rd Spry2 Ncam1 Fgfr1 Src Ssh1 Fgfr2 Rps6ka1 Sdc2 Ptpn11 Stat1 Pik3r1 Gab1 Frs2 Grb2 Cdh1 Mapk1 Pdpk1 Sos1 Camk2a Jun Cttn Pak4 Mapk3 Fgf19 Runx2 Spp1 Fos Bglap Plcg1 Cbl Ptk2b Mmp9 Plau Ctnnd1 Fgf23 Fgfr3 Stat5b Fgfr4 Cdh2 Akt1 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Bmpr2 Smad1 Acvr1 Smad4 Tlx2 Smad9 Amhr2 Amh Bmp7 Fkbp1a Smad5 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Xrcc6 Brca1 Pelp1 Cdk6 Xrcc5 Med1 Tmprss2 Ar Ncoa2 Nrip1 Ccnd1 Casp8 Kdm1a Pawr Uba3 Hip1 Lats2 Fhl2 Kdm4c Zfp318 Prdx1 Ube2i Fkbp4 Rps6ka3 Ctnnb1 Mak Pias1 Pa2g4 Ube3a Svil Tmf1 Ctdsp1 Nkx3-1 Zmiz1 Srf Snurf Ncoa4 Ncoa6 Ccnd3 Kdm3a Vav3 Tgfb1i1 Gsn Tcf4 Ptk2b Cdkn2a Pias3 Tgif1 Pias4 Akt1 Prkdc Carm1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Casr Fmn1 Ajuba Src Egfr Ctnnd1 Akt2 Pik3r1 Fyn Ctnnb1 Vasp Cdh1 Jup Zyx Akt1 Rhoa Ctnna1 Rac1 Plcg1 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Lmo4 Map2k4 Il6st Stat3 Ptpn11 Stat1 Pik3r1 Gab1 Cebpb Il6r Pias1 Jak1 Grb2 Hck Sos1 Jun Bcl2l1 Rac1 Fos Mitf Timp1 Map2k6 Prkcd Crp Vav1 Hsp90b1 Lbp Mcl1 Ptpre Junb Fgg Tnfsf11 A2m Mapk14 Socs3 Mapk11 Pias3 Irf1 Il6 Myc Akt1 Gab2 Jak2 Foxo1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Epha2 Epha3 Epha4 Epha6 Epha7 Epha8 Efna5 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Fancd2 Topbp1 Atr Mdm2 Cdc25a Ccna2 Ywhab Chek1 Ppp2ca Rfc5 Plk1 Rfc3 Clspn Rfc4 Fbxw11 Ywhaz Rfc2 Hus1 Rpa2 Rad17 Atrip Ppp2r1a Cdk2 Brca2 Rad1 Mcm7 Btrc Smarcal1 Ppp2r2b Timeless Cdc25c Cep164 Cdc6 Tipin Mcm2 Nbn Rad51 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Gsk3b Wnt3a Dvl3 Apc Axin1 Fzd5 Axin2 Csnk1a1 Btrc Gsk3a Ctnnb1 Cul1 Skp1 Lrp6 Csnk1d Csnk1e Dvl1 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Shc1 Irs1 Pxn Irs2 Grb10 Raf1 Ptpn11 Pik3r1 Rack1 Ptk2 Ywhae Grb2 Igf1 Pdpk1 Sos1 Crk Hras Bcar1 Igf1r Bad Prkcd Ywhaz Rps6kb1 Crkl Nck2 Prkd1 Akt1 Prkcz Ptpn1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Map2k6 Map2k4 Map2k3 Il1b Pgr Il18 Tnf Vcam1 Mapk1 Map2k2 Antxr1 Casp1 Mapk3 Map2k1 Map2k7 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Sag Rdh12 Rgs9bp Gnb1 Grk1 Gucy2e Rpe65 Guca1b Gnb5 Guca1a Rgs9 Lrat Gucy2f Gngt1 Slc24a1 Cngb1 Pde6a Pde6b Gnat1 Cnga1 Rho FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Onecut1 Foxm1 Cks1b Tgfa Lama4 Xrcc1 Cenpf Aurkb Gsk3a Sp1 Ccna2 Map2k1 Fos Ccnb1 Ccnd1 Plk1 Esr1 Mmp2 Crebbp Cdk4 Nfatc3 Cdk2 Cdkn2a Brca2 Cdk1 Rb1 Etv5 Skp2 Cenpa Cdc25b Ccne1 Myc Chek2 Ccnb2 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Gna14 Prkcb Prkce Pld1 Cxcr1 Plcb2 Gnai2 Lyn Fgr Hck Prkca Pdpk1 Dnm1 Plcb3 Pik3r6 Pik3cg Plcb1 Rab5a Grk2 Cbl Arrb1 Prkcg Gnb1 Arrb2 Akt1 Gna15 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Fcgr2a Itgam Kng2l1 Spon2 Itgb2 Proc Gp1ba Itgal Fgb Fga F10 F11r Icam2 Ccn1 Thy1 Cd40lg Plau Fgg Jam3 Plat Icam1 C3 Vcam1 Itgad Itgax INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Gsk3b Ywhaz Prkci Akt2 Asip Trip10 Ywhah Ppp1r3a Ywhag Vamp2 Ywhae Ins2 Gys1 Stxbp4 Lnpep Slc2a4 Rhoq Ywhab Akt1 Ppp1cc Sfn Prkcz Insr Stx4 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Afdn Sphk1 S1pr1 Ptpn2 Raf1 Pdgfrb Pdgfb Nckap1 Arhgap35 Rap1b Wasf2 Cttn Map2k2 Sla Arap1 Map2k1 Rab4a Abi1 Usp6nl Tagln Myocd Actn4 Map2k7 Nherf2 Nherf1 Sipa1 Pik3cb Brk1 Arhgdia Mapk10 Baiap2 Arpc1b Actr2 Actr3 Eif2ak2 Arpc3 Arpc2 Arpc5 Jak2 Arpc4 Map2k4 Blk Stat5a Stat3 Stat1 Pik3r1 Lyn Fgr Mapk8 Hck Pak1 Mapk1 Itgav Mapk3 Rhoa Srf Bcar1 Ppp2ca Rac1 Pten Ppp2r1a Pin1 Ptpn1 Csk Shc1 Rasa1 Src Grb10 Ptpn11 Nck1 Rap1a Gab1 Dok1 Braf Ywhah Elk1 Ywhag Grb2 Ywhae Prkca Sos1 Crk Ywhab Hras Sfn Jund Pla2g4a Plcg1 Eps8 Rab5a Prkcd Ywhaz Mapk9 Lrp1 Vav2 Kras Nras Prkce Abl1 Fyn Yes1 Rps6ka3 Jun Pik3r6 Pik3cg Fos Dnm2 Cbl Iqgap1 Nck2 Ppp2r2b Stat5b Myc Lck Ptprj ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Fkbp1a Acvrl1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Afdn Src Pik3r1 Pdgfrb Rap1a F11r Pdgfb Ptk2 Ctnnb1 Cdh1 Rap1b Crk Itgav Rac1 Ctnna1 Nectin1 Farp2 Nectin3 Ptprm Cldn1 Iqgap1 Tln1 Pip5k1c Vav2 Nectin2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Ppp3ca Shc1 Rasa1 Raf1 Dok1 Elk1 Grb2 Pdpk1 Sos1 Hras Map2k1 Ikbkb Ikbkg Cd72 Cd22 Malt1 Cd79b Traf6 Btk Bcl2a1 Bcl10 Ptprc Nfkbib Ppp3cc Ppp3cb Sh3bp5 Vav2 Map4k1 Nfkb1 Fcgr2b Nfkbia Rela Csnk2a1 Pik3r1 Lyn Ets1 Mapk8 Mapk1 Jun Dapp1 Mapk3 Plcg2 Blnk Rac1 Fos Inpp5d Syk Ptpn6 Map3k7 Map3k1 Pten Chuk Mapk14 Akt1 Camk2g Csk REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Arhgdib Arhgef11 Arhgef28 Trio Arhgap35 Mcf2l Ect2 Arap1 Rhoa Mcf2 Arhgef2 Arhgef1 Abr Vav3 Arhgef25 Vav1 Bcr Arhgap9 Arhgef15 Arhgdia Ngef Srgap1 Vav2 Arhgef5 Arhgef3 Ophn1 Arhgap5 Arhgdig Arhgef12 Arhgef18 Cdkn1b Farp1 Net1 Arhgap4 Arhgap8 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Syt1 Rab3gap2 Stx1a Vamp2 Stxbp1 Unc13b Chrna1 Snap25 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Gata3 Eno1 Ncstn Aph1b Dnm1 Psenen Ncor2 Ccnd1 Maml1 Maml2 Cdkn1a Kdm1a Rbbp8 Rab11a Yy1 Notch1 Furin Adam12 Mark2 Adam10 Neurl1 Notch4 Notch2 Notch3 Dll1 Dll3 Dll4 Mfap5 Jag2 Jag1 Mfap2 Dlk1 Mib1 Cntn1 Numb Cntn6 Dner Eps15 Lnx1 Il4 Cbl Btrc Ptcra Skp2 Cul1 Ctbp1 Skp1 Itch Myc Hdac1 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Gpc2 Mdk IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Shc1 Foxp3 Stat5a Cdk6 Ptpn11 Pik3r1 Jak3 Sp1 Jak1 Grb2 Ccna2 Elf1 Sos1 Bcl2l1 Il2ra Ccnd3 Il2 Lta Il4 Ccnd2 Faslg Prf1 Il2rg Stat5b Myc Gab2 Lck Bcl2 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Nras Shc1 Src Raf1 Stat3 Ptpn11 Pik3r1 Grb2 Mapk8 Mapk1 Sos1 Erbb3 Jun Map2k2 Nfatc4 Hras Mapk3 Nf2 Map2k1 Chrne Usp8 Prkaca Rnf41 Rac1 Bad Fos Erbb2 Mapk9 Mtor Pik3cb Nrg2 Mapk10 Ppp3cb Akt1 Kras Jak2 Nrg1 Chrna1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Gna14 Prkcb Plcb2 Pld2 Elmo1 Gnai2 Lyn Fgr Hck Prkca Pdpk1 Dnm1 Plcb3 Ppp2ca Pik3r6 Cxcr2 Pik3cg Rab7a Dock2 Plcb1 Rac2 Rab5a Cbl Arrb1 Prkcg Gnb1 Ppp2r1a Arrb2 Rab11a Vasp Akt1 Gna15 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc1 Sdc3 Sdc4 Sdc2 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions Sphk1 Itga2b Lama4 Vtn Fn1 Fgb Pdgfrb Fga Vegfa F11r Pdgfb Lamb1 Itgav Ccn1 Spp1 Thy1 L1cam Cd47 Col1a1 Ibsp Col4a3 Plau Fbn1 Sdc4 Fgg Col4a1 Lamc1 Col4a5 Sdc1 Tgfbr2 Col1a2 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Shc1 Rasa1 Irs1 Irs2 Raf1 Ptpn11 Grb2 Sos1 Map2k2 Hras Map2k1 Mapk9 Cdk2 Socs3 Mapk11 Kras Nras Prkcb Prkce Stat5a Stat3 Stat1 Pik3r1 Socs1 Fyn Jak3 Jak1 Mapk8 Mapk1 Jun Mapk3 Rhoa Il2ra Dok2 Fos Il2 Syk Ifng Ptk2b Cish Socs2 Stam2 Ikzf3 Stam Mapk14 Il2rg Stat5b Myc Gab2 Lck Bcl2 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc2 Gpc3 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Atr Npas2 Bhlhe40 Nr1d1 Nono Cry1 Cry2 Timeless Clock Bmal1 Per2 Per1 Wdr5 Chek1 Csnk1e IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Map2k6 Cd3g Cd247 Il12rb2 Cd3d Il12a RT1-Da Tbx21 RT1-Db1 Stat4 Il18 Il12b Cd3e Cd4 Ripk2 Nfkb1 Jak2 Nos2 Sphk2 Rela Eomes Stat5a Il18r1 Il1b Cd8b Stat3 Cd8a Stat1 Socs1 B2m Stat6 Il2ra Fos Rab7a Il2 Il4 Ifng Mtor Faslg Map2k3 Atf2 Mapk14 Il2rg Nfkb2 Ccr5 Gadd45g Gzma Gadd45b Hlx Lck Ccl4 Il1r1 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Itgb7 Madcam1 Vtn Plau Fbn1 Itga4 Fn1 Sdc1 Vcam1 Itgav Itgb8 Ccn1 Tgfbr1 Itgb6 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Pik3c2a Irs1 Src Pxn Vtn Fn1 Ptpn11 Vegfa F11r Ptk2 Igf1 Col11a1 Rock1 Col11a2 Igf1r Col2a1 Col3a1 Col1a1 Casp8 Col4a3 Col5a2 Col6a2 Col4a1 Col5a1 Col4a5 Sdc1 Cdkn1b Fgf2 Pik3r1 Mapk1 Ilk Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Vav3 Cbl Ptk2b Rps6kb1 Tln1 Vcl Hsp90aa1 Akt1 Csf1 Csf1r Angptl3 Tgfbr2 Mfge8 Col1a2 Pi4kb SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Tubb2a Sirt3 Mef2d Crebbp Sirt2 Acss1 Sirt1 Acss2 Bax Xrcc6 Ppargc1a Myod1 Fhl2 Cdkn1a Hdac4 Foxo4 Foxo3 Tp53 Foxo1 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Mnat1 Ccnh Rxrb Rxra Cdk7 Rara Rbp1 Rarg Rxrg Ncoa2 Ncoa1 Mapk8 Prkca Mapk1 Nrip1 Mapk3 Prkaca Ncor2 Vdr Crebbp Prkcg Cdk1 Mapk14 Hdac1 Hdac3 Akt1 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Arnt Hif1a Rbx1 Hif3a Cdkn2a Os9 Hif1an Rack1 Naa10 Egln2 Cul2 Egln3 Vhl Hsp90aa1 Eloc Tp53 Cops5 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Vtn Brca1 Pisd Cebpb Sftpd Ar Nfib Nfia Nfic Scgb1a1 Sp1 Nr2f2 Gcg Col18a1 C4bpb Jun Serpina1 Nrip1 Nkx3-1 Sftpa1 Fos Foxa1 Esr1 Shh Ap1b1 Foxa2 Pou2f1 Foxa3 Crebbp Dscam Tff1 Atp5pf Apob Xbp1 Sod1 Ndufv3 Ins2 Prdm15 Cdkn1b NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Dvl3 Cthrc1 Fzd2 Fzd5 Fzd6 Tab2 Yes1 Ror2 Mapk8 Camk2a Daam1 Flna Rock1 Rhoa Chd7 Rac1 Mapk9 Map3k7 Nfatc2 Csnk1a1 Arrb2 Mapk10 Nlk Prkcz Wnt5a Dvl1 Pparg PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Gna14 Nras Shc1 Gnaq Src Gnai1 Plcb2 Pelp1 Gnai3 Pik3r1 Gnaz Gnao1 Gnai2 Nos3 Grb2 Igf1 Sos1 Hras Gna13 Rhoa Bcar1 Gnal Plcb3 Strn Igf1r Plcb1 Esr1 Mmp2 Msn Mmp9 Hbegf Gnb1 Rock2 Mapk11 Esr2 Akt1 Kras Gna11 Gna15 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Ar Camk4 Ncoa2 Ywhah Ywhag Ywhae Ywhab Id2 Sfn Ruvbl2 Cacna1g Vcan Myog Ccnd1 Neurog1 Mitf Mdfic Igf2bp1 Ccnd2 Cby1 Ywhaz Fgf4 Zcchc12 Tbl1xr1 Kcnip4 Tnik Adcy7 Mt-co2 Axin2 Hbp1 Tle4 Med12 Tle2 Krt1 Tle1 Tle5 Dkk4 Chd8 Smarca4 Tcf7 Tbl1x Sp5 Cdx4 Cdx1 Ctnnbip1 Klf4 Pitx2 Myf5 Dvl3 Incenp Xpo1 Dkk1 Ctnnb1 Cdh1 Jun Ccn1 Tcf7l2 Tcf4 Mmp2 Mmp9 Apc Cdkn2a Btrc Hdac2 Cul1 Ctbp1 Skp1 Lef1 Myc Hdac1 Tcf7l1 Tert Tbxt EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Shc1 Irs2 Stat5a Ptpn11 Stat1 Pik3r1 Rap1a Gab1 Lyn Grb2 Mapk8 Sos1 Hras Bcl2l1 Plcg2 Plcg1 Inpp5d Ptpn6 Cbl Epo Btk Mapk14 Crkl Socs3 Stat5b Vav2 Epor Tec Nfkb1 Bcl2 Jak2 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Map2k6 Map3k7 Map3k1 Map2k3 Atm Traf6 Tab2 Mapk14 Map3k3 Mapk11 Txn1 Camk2b Gadd45g Gadd45b Taok1 Taok3 Map3k6 Rac1 Map3k4 Traf2 Gadd45a Map3k10 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Gsk3b Ruvbl1 Axin1 Zbtb17 Hbp1 Cdkn2a Max Ppp2r5a Skp2 Actl6a Pak2 Myc Taf9 Kat5 Pin1 Ruvbl2 Ppp2ca Kat2a Supt7l S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Abcc1 Sphk1 S1pr1 Gnai1 Plcb2 Gnai3 Ptgs2 Gnaz Pdgfrb Gnao1 Gnai2 Vegfa Pdgfb Mapk1 Mapk3 Rhoa Rac1 Plcg1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Prnp Pla2g2a Slit2 Fgfr1 Serpinc1 Src Cripto Blk App Lama1 Vegfa Fyn Lyn Yes1 Fgr Hck Smad2 Flt1 Tgfb1 Tgfb3 Fgf2 Lck Tgfbr1 Tgfbr2 Nrg1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Gna14 Gnaq Src Gnai1 Raf1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Prkca Crk Map2k2 Hras Map2k1 Gnal Pla2g4a Prkcd Col3a1 Adcy7 Mmp1 Jak2 Prkcb Prkce Ednrb Ednra Adcy3 Prkcq Plcb2 Adcy4 Adcy1 Adcy2 Adcy8 Adcy5 Adcy6 Edn2 Edn3 Prkch Cysltr2 Cysltr1 Edn1 Mapk8 Mapk1 Jun Mapk3 Rhoa Bcar1 Plcb3 Slc9a1 Rac1 Fos Plcb1 Trpc6 Slc9a3 Ptk2b Prkcg Mapk14 Akt1 Gna11 Col1a2 Gna15 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Nrp1 Vegfd Nrp2 Vegfc Flt4 Pgf Flt1 Vegfa NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Map2k4 Prkci Pik3r1 Nck1 Fyn Grb2 Mapk8 Nphs2 Jun Nphs1 Tjp1 Cd2ap Kirrel1 Rac1 Bad Pard6a Plcg1 Trpc6 Mapk9 Pik3cb Nck2 Arrb2 Mapk10 F2rl2 Akt1 Prkcz LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Gna14 Gnaq Src Egfr Pxn Gnai1 Gnai3 Gna12 Gnaz Gab1 Gnao1 Gnai2 Tiam1 Ptk2 Crk Hras Plcg1 Nherf2 Gsk3b Prkcd Pik3cb Adcy7 Casp3 Nfkb1 Prkce Nfkbia Rela Adcy3 Adcy4 Adcy1 Adcy2 Pld2 Adcy8 Pik3r1 Adcy5 Adcy6 Lyn Jun Gna13 Rhoa Lpar4 Bcar1 Plcb3 Lpar3 Rac1 Lpar2 Fos Lpar1 Arhgef1 Adra1b Mmp2 Ptk2b Mmp9 Hbegf Gnb1 Prkd1 Akt1 Gna11 Gna15 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Lama4 Vtn Fn1 Fgb Fga Lama1 Lama3 Vegfa Col18a1 Col11a1 Col11a2 Col2a1 Col3a1 Col1a1 Col4a3 Col5a2 Col6a2 Col4a1 Lamc1 Col5a1 Mdk Col4a5 Jam2 Cd81 Lama5 Vcam1 Igsf8 Cd14 Thbs2 Itga10 Itga3 Itga7 Itga8 F13a1 Itga5 Itga6 Itga9 Itgb1 Tgm2 Itga4 Itga1 Itga2 Lamb2 Lamb3 Lama2 Lamb1 Itgav Spp1 Nid1 Cspg4 Plau Fbn1 Fgg Col1a2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Plg Itgb1 Src Itgam Egfr Vtn Serpine1 Fn1 Itgb2 Fgb Dock1 Pdgfrb Fga Crk Itgav Bcar1 Rac1 Ctsg Fpr1 Klk4 Mmp9 Fpr3 Fpr2 Plau Lrp1 Gpld1 Mmp12 Mmp13 Fgg Tgfb1 Ctrc Hgf Vldlr Mmp3 Elane Itga3 Itga5 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Ndrg2 Tjp2 Rbl1 Brca1 Max Pdgfrb Sp1 Ddit3 Id2 Ccl5 Ccnd1 Gadd45a Cflar Smad2 Smad3 Smad4 Zbtb17 Cdkn1a Cdkn1b Hdac3 Wnt5a Lgals1 Itga6 Itgb1 Itgb4 Dntt Spi1 Dkk1 Erbb2 Tmeff2 Gfi1 Aldh9a1 Clu Irf8 Fth1 Tmem126a Sfrp1 Ptpa Tbp Csde1 Tsc2 Myc Hmgcs2 Hdac1 Nfyb Nfya Nfyc Cebpa Zfp36l1 Cdkn2b Dnmt3a Foxo3 Gtf2h2 Bcl2 Slc11a1 Creb1 Sfxn3 Col1a2 Ndrg1 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Erbb2 Erbb4 Areg Tgfa Egfr Ereg Hbegf Nrg2 Btc Nrg4 Nrg3 Egf Hsp90aa1 Erbb3 Nrg1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Tubb2a Ankra2 Rfxank Gata2 Hdac11 Nr3c1 Hdac10 Ranbp2 Xpo1 Hdac4 Ube2i Camk4 Ran Ywhae Ywhab Srf Ncor2 Esr1 Grk2 Mef2c Gnb1 Bcl6 Hsp90aa1 Gata1 Hdac3 Hdac7 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Shc1 Eif2a Smurf1 Strap Dynlrb1 Axin1 Dab2 Dact2 Tgfbrap1 Xiap Zfyve16 Ppp2cb Tab2 Tgfbr3 Sptbn1 Nedd4l Ppp2r2a Rnf111 Ppp1r15a Zfyve9 Ctnnb1 Smurf2 Bambi Ywhae Grb2 Pdpk1 Sos1 Camk2a Fkbp1a Ppp2ca Pard6a Map3k7 Smad2 Smad3 Smad4 Rps6kb1 Ccn2 Tgfb1 Tgfb3 Arrb2 Smad7 Ppp1ca Cav1 Itch Wwp1 Tgfbr1 Tgfbr2 Daxx ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Itgb7 Cdh1 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Prkcb Map2k4 Map3k7 Map3k1 Lat Crkl Map3k8 Grap2 Dbnl Mapk8 Map4k1 Jun Crk Lcp2 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Prkcb Mef2d Prkce Bax Csnk2a1 Prkcq Xpo1 Prkch Camk4 Map3k8 Ywhah Kpnb1 Ran Ywhag Ywhae Nr4a1 Mapk8 Fkbp8 Prkca Kpna2 Ywhab Chp1 Rcan2 Mapk3 Bcl2l1 Fkbp1a Sfn Prkaca Bad Gsk3b Cabin1 Prkcd Crebbp Ywhaz Mapk9 Akap5 Prkcg Map3k1 Pim1 Casp3 Nfatc3 Nfatc2 Csnk1a1 Mapk14 Prkcz Bcl2 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Shc1 Lat Ptpn11 Nck1 Rap1a Map3k8 Grb2 Dbnl Prkca Pdpk1 Sos1 Sla2 Orai1 Hras Stim1 Flna Stk39 Rassf5 Ikbkb Fyb1 Sh3bp2 Ikbkg Plcg1 Vav1 Cd3g Cd247 Malt1 Cd3d Cd28 Traf6 RT1-Da Cd86 Bcl10 Cd80 Ptprc RT1-Db1 Itk Grap2 Cd3e Map4k1 Cd4 Kras Lcp2 Nras Prkcb Prkce Rasgrp1 Prkcq Rasgrp2 Fyn Zap70 Inpp5d Ptpn6 Cbl Pten Chuk Map3k14 Akt1 Gab2 Lck Trpv6 Csk VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Prkcb Rasa1 Cbl Hif1a Flt1 Shc2 Ptpn11 Pik3r1 Nck1 Vegfa Cav1 Nrp1 Nos3 Nrp2 Prkca Mapk1 Pgf Hsp90aa1 Pdpk1 Mapk3 Akt1 Cd2ap Prkaca Plcg1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Shc1 Edn1 Egf Grb2 Mtor Egfr Ednra Sos1 Hras HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Gnai1 Gnai3 Gnaz Gnao1 Xpo1 Gnai2 Pias1 Sap18 Map2k1 Prkaca Rab23 Gli1 Rbbp7 Gli2 Mtss1 Gsk3b Shh Ift88 Foxa2 Prkcd Kif3a Fbxw11 Crebbp Stk36 Smo Sufu Ptch1 Spop Gnb1 Csnk1a1 Csnk1g3 Btrc Csnk1g1 Arrb2 Csnk1g2 Hdac2 Hdac1 Akt1 Csnk1d Csnk1e Lgals3 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Shc1 Rasa1 Irs1 Prkci Grb10 Akt2 Ptpn11 Pik3r1 Nck1 Dok1 Trip10 Grb2 Pdpk1 Sos1 Rhoq Crk Hras Exoc3 Eif4ebp1 Exoc5 Pard6a Exoc6 Inpp5d Exoc2 Cbl Exoc7 Rps6kb1 Nck2 Cav1 Ptpra F2rl2 Ins2 Sh2b2 Akt1 Grb14 Prkcz Sgk1 Insr Foxo3 Ptpn1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfb Pdgfra Pdgfc Pdgfrb Pdgfa EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Shc1 Cbl Src Acp1 Efna1 Pik3r1 Tiam1 Ptk2 Epha2 Vav2 Arhgap35 Grb2 Pak1 Inppl1 Rhoa Bcar1 Rac1 Vav3 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Sh2d2a Src Egfr Raf1 Rictor Mapkap1 Gab1 Ppp2r2a Mlst8 Braf Ywhah Nckap1 Elk1 Ywhag Ywhae Egf Grb2 Prkca Wasf2 Pdpk1 Sos1 Map2k2 Ywhab Hras Map2k1 Abi1 Atf1 Usp6nl Sfn Egr1 Bad Eps8 Rab5a Prkcd Ywhaz Mapk9 Dusp1 Pik3cb Mef2c Arf4 Rps6ka5 Ppp5c Zfp36 Map3k2 Brk1 Myl11 Map2k5 Dusp6 Baiap2 Ralgds Vav2 Arpc1b Actr2 Actr3 Arpc3 Arpc2 Kras Prkcz Arpc5 Arpc4 Nras Map2k4 Pebp1 Pld1 Rin1 Stat3 Pld2 Stat1 Pik3r1 Rps6ka3 Capn2 Mapk8 Mapk1 Jun Mapk3 Bcl2l1 Rala Srf Ppp2ca Slc9a1 Rac1 Fos Map3k1 Mtor Ppp2r1a Iqgap1 Atf2 F2rl2 Smad1 Rps6 Akt1 Creb1 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Csnk2a1 Nudc Dynlt1 Abl1 Map1b Ywhae Rhoa Rac1 Lrpap1 Iqgap1 Vldlr Pafah1b3 Pafah1b2 Lrp8 Pafah1b1 Dab1 Dync1h1 Ppp2r5d Pla2g7 Cdk5 Katna1 Cdk5r2 Cdk5r1 Ndel1 Reln Dcx SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Agt Rabggtb Atf5 Itgb1 Src Itga1 Cdk2 Rhoc Cdkn1a Ccne1 Ccna2 Mapk1 Mapk3 Rock1 Rhoa Bcar1 Egr1 Ptp4a3 Rac1 Ptp4a1 Rabggta EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Map2k4 Rgs3 Map3k7 Src Itga2b Blk Pik3r1 Nck2 Ephb1 Ephb2 Fyn Lyn Tiam1 Yes1 Efnb1 Efnb2 Fgr Mapk8 Hck Dnm1 Lck Ptpn13 Rac1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Shc1 Map2k4 Itgb1 Vegfd Col1a1 Vegfc Rps6ka1 Itga4 Fn1 Itga1 Itga2 Pik3r1 Mapk14 Mapk11 Grb2 Flt4 Mapk1 Sos1 Crk Mapk3 Akt1 Creb1 Col1a2 Itga5 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Gna14 Gnaq Gulp1 Src Fbxo8 Itga2b Pxn Acap2 Egfr Lhcgr Arap2 Nck1 Cyth2 Tshr Egf Cyth3 Agtr1a Adrb2 Git1 Acap1 Adap1 Arrb1 Efna1 Arf6 Hgf Arrb2 Epha2 Met Gna11 Gna15 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Serpine1 Cdk6 Rack1 Ada Rchy1 Sp1 Ccna2 Tp63 Kat5 Serpina1 Casp2 Ntrk1 Sfn Hey2 Plk3 Cdk2 Fas Rb1 Cdkn1a Mapk11 Prkacb Plpp1 Gata1 Sirt1 Bax Rela Pfdn5 Tuba1a Ccne2 Pea15 Il1rap Clca2 Jag2 Ndufs2 Nedd4l Hagh Abl1 Gramd4 Aen Mdm2 Dcp1b Rnf43 Jak1 Dedd Flot2 Afp Hsf1 Wt1 Bub1 Bak1 Chek1 Ube4b Tp73 Nsg1 Gdf15 Ccnb1 Wwox Plk1 Bin1 Brca2 Cdk1 Mapk14 Il4r Bcl2l11 Itch Myc Pin1 Foxo3 Rad51 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Nras Src Gnai1 Raf1 Rictor Gnai3 Pik3r1 Gnaz Mapkap1 Gnao1 Mlst8 Gnai2 Mapk1 Pdpk1 Dnm1 Map2k2 Hras Mapk3 Map2k1 Cxcl11 Cxcl10 Cxcr3 Map2k6 Pf4 Cxcl13 Arrb1 Mtor Pik3cb Gnb1 Ccl11 Map2k3 Mapk14 Mapk11 Cxcl9 Akt1 Kras IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Inpp5d Shc1 Csf2rb Ywhaz Cnksr1 Il3ra Cish Srp9 Stat5a Pim1 Ptpn11 Pik3r1 Id1 Osm Cebpb Stat5b Prkacb Ywhag Grb2 Hdac1 Bcl2l1 Gab2 Prkaca Jak2 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Gna14 Gnaq Src Egfr Gna12 Gnai2 Nos3 Egf Prkca Dnm1 Rock1 Sele Nherf1 Prkcd Grk2 Icam1 Mapk11 Rab11a Vcam1 Prkcz Prkcb Prkce Blk Tgm2 Arr3 Prkcq Plcb2 Fyn Gnb5 Prkch Lyn Yes1 Fgr Hck Gna13 Rhoa Prkaca Pik3r6 Rac1 Pik3cg Arhgef1 Syk Grk3 Prkcg Ptgdr Gnb1 Ptgir Tbxa2r Mapk14 Arrb2 Akt1 Lck Gna11 Gna15 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Shc1 Itga6 Il1a Itgb1 Egfr Lama4 Rxrb Itgb4 Rxra Rxrg Pik3r1 Lama1 Lama3 Ywhah Ywhag Lamb2 Ywhae Lamb3 Casp7 Egf Grb2 Cdh1 Lama2 Prkca Lamb1 Erbb3 Ywhab Hras Sfn Rac1 Erbb2 Ywhaz Rps6kb1 Col17a1 Pmp22 Lamc1 Mst1r Lama5 Met Mst1 Akt1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Irs1 Raf1 Rictor Mapkap1 Mlst8 Braf Ywhah Ywhag Srebf1 Ywhae Prkca Pdpk1 Map2k2 Ywhab Hras Map2k1 Sfn Ikbkb Eif4ebp1 Ywhaz Eif4e Eif4a1 Ppargc1a Cdk2 Yy1 Kras Cycs Nras Rps6ka1 Pld1 Pld2 Rptor Mapk1 Mapk3 Akt1s1 Fbxw11 Mtor Rps6kb1 Prr5 Rraga Btrc Ddit4 Rragb Rragc Rragd Tsc1 Eef2k Eif4b Ulk1 Ccne1 Ulk2 Tsc2 Rb1cc1 Rrn3 Poldip3 Pdcd4 Akt1 Bnip3 Atg13 Sgk1 Eef2 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Nfkb2 Chuk Map3k14 Nfkb1 Btrc DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Casp6 Tgfa Egfr Serpine1 Atf3 Sp1 Tp63 Col18a1 Taf9 Kat2a Vdr Pou4f1 Crebbp Pou4f2 Bid Cd82 E2f3 Plk3 Bcl2a1 Fas Rb1 Cdkn1a Ctsd Bax Mdm2 Afp Bak1 Tp73 Spp1 Gdf15 Ccnb1 Foxa1 Mmp2 Pten Apc Cse1l Ddit4 Bdkrb2 Cav1 Igfbp3 Ccng1 Drosha Tp53 Ccnk Carm1 Pcbp4 Tap1 Hic1 Ppp1r13b Pcna Msh2 Perp Tyrp1 Tnfrsf10b Sh2d1a Sesn1 Steap3 Tada2b Fdxr Ddx5 Btg2 Apaf1 Lif Rrm2b Tp53bp2 Prmt1 Rchy1 Bcl2l14 Gpx1 Bcl2l2 Bnip3l Pidd1 Rnf144b Triap1 Irf5 Serpinb5 Aifm2 Dgcr8 Htt Scn3b Casp1 Zfp385a Sfn Pms2 Cx3cl1 Vcan Pycard Mlh1 Gadd45a Tp53inp1 Tigar Dusp5 Cebpz Nlrc4 Dusp1 Prdm1 Prkab1 Ppm1j Hgf Epha2 Smarca4 Met Edn2 Dkk1 Jun Bcl2l1 Mcl1 Bcl6 Hdac2 Tsc2 Nfyb Nfya Nfyc Bcl2 E2f1 Ndrg1 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Prkce Adcy3 Rps6ka5 Adcy4 Adcy7 Adcy1 Adcy2 Adcy8 Adcy5 Adcy6 Gnal Lpar4 Prkaca Creb1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Src Adam10 Hgs Egfr Gdnf Gfra1 Gna12 Abl1 Fyn Tiam1 Ctnnb1 Egf Cdh1 Jup Ntrk2 Rin2 Hras Gna13 Igf1r Rac1 Ctnna1 Rab7a Rab5a Ptpn6 Nme1 Crebbp Snx1 Dnm2 Mmp7 Slit1 Cbll1 Dsp Casp3 Ctnnd1 Iqgap1 Cables1 Igf2 Arf6 Robo1 Zbtb33 Mmp3 Met Cdh2 Ret Ptpn1 Bdnf AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Rasa1 Tacc1 Nfkbia Brca1 Aurkb Mdm2 Ran Arhgef7 Fzr1 Pak1 Git1 Prkaca Gadd45a Gsk3b Ajuba Tpx2 Aurkaip1 Oaz1 Cpeb1 Dlgap5 Tacc3 Tdrd7 Aurka Cenpa Cdc25b Ppp2r5d Akt1 Ndel1 Ckap5 Tp53 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Map2k4 Nfkbia Rela Stat5a Pik3r1 Jak3 Mapk8 Jun Bcl2l1 Pik3r6 Birc2 Pik3cg Il4 Birc3 Mapk9 Cd40lg Pik3cb Map3k1 Map3k14 Traf6 Mapk14 Mapk10 Mapk11 Fcamr Traf3 Cd40 C4bpa Myc Tdp2 Cblb Akt1 Nfkb1 Traf2 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network Nr0b1 Nr0b2 Smarce1 C3 Ncoa2 Smarca4 Ncoa1 Esr2 Smarcb1 Uba3 Zfp709 Nedd8 Ube2m SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurka Aurkc Aurkb LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Cab39 Strada Etv4 Mark2 Stk11 Psen2 Sik1 Brsk2 Brsk1 Mlst8 Rptor Ywhah Ywhag Ywhae Ywhab Akt1s1 Sfn Prkaca Esr1 Gsk3b Ywhaz Mtor Smad4 Ezr Tsc1 Ctsd Tsc2 Hsp90aa1 Myc Cdc37 Stk11ip Stk26 Mark4 Crtc2 Tp53 Map2 Stradb Creb1 Smarcd3 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb3 Efnb1 Efnb2 Ephb1 Ephb2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Nras Rps6ka1 Raf1 Ntf3 Rap1a Braf Rit1 Rit2 Elk1 Ehd4 Rap1b Mapk1 Hras Mapk3 Map2k1 Srf Trpv1 Egr1 Fos Map2k6 Prkcd Mef2c Map2k3 Rps6ka5 Map3k2 Mapk14 Map2k5 Cdk5 Cdk5r1 Kras Creb1 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Sqstm1 Rela Prkci Nrk Map4k5 Map4k3 Stat1 Tnfrsf1b Tab2 Rack1 Cyld Map4k2 Rffl Ikbkb Birc2 Ikbkg Map2k7 Birc3 Map3k7 Adam17 Map3k1 Casp8 Tnik Map2k3 Chuk Ripk1 Map3k3 Fadd Cav1 Smpd2 Txn1 Smpd1 Tnf Nsmaf Madd Tnfrsf1a Bag4 Prkcz Nfkb1 Traf2 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Nr3c1 Pklr Cebpb Tat Dlk1 Aldob Nkx2-1 Acadvl Hmgcs1 Sp1 Ttr Afp Igfbp1 Slc2a2 Ucp2 Pck1 Acadm Gck Cpt1a Bdh1 Abcc8 Kcnj11 Foxa1 Alb Foxa2 Hnf1a Tfrc Foxa3 Cpt1b Cpt1c Hadh Hnf4a Ins2 Nf1 G6pc1 Cebpa Akt1 Creb1 F2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Src Raf1 Tiam1 Braf Enah Hras Dlg1 Map2k7 Eps8 Gsk3b Map2k6 Mapk9 Arhgdia Baiap2 Iqgap3 Vav2 Arpc1b Actr2 Actr3 Pak2 Arpc3 Arpc2 Prkcz Arpc5 Arpc4 Map3k11 Map2k4 Prkce Pld1 Pik3r1 Yes1 Ctnnb1 Arhgef7 Mapk8 Cdh1 Pak1 Mapk1 Arhgef6 Jun Pak4 Mapk3 Bcar1 Rac1 Ctnna1 Pard6a Cfl1 Cbl Cdc42bpa Map3k1 Mtor Apc Septin2 Exoc7 Pax6 Map2k3 Myl2 Rps6kb1 Hes5 Iqgap1 Tnk2 Limk1 Limk2 Atf2 Mapk14 F2rl2 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Hgs Src Pxn Gnai1 Rictor Gnai3 Ptpn11 Rack1 Gnaz Mapkap1 Gnao1 Mlst8 Gnai2 Ptk2 Rap1b Pdpk1 Dnm1 Crk Bad Grk2 Vav1 Cd3g Pik3cb Cd247 Cd3d RT1-Da Stat2 Rhoc Ptprc Rhob RT1-Db1 Cd3e Cd4 Prkcz Jak2 Cxcr4 Ssh1 Blk Stat5a Arr3 Plcb2 Stat3 Stat1 Pik3r1 Fyn Lyn Yes1 Fgr Hck Pak1 Gna13 Rhoa Bcar1 Plcb3 Pik3r6 Rac1 Pik3cg Plcb1 Inpp5d Ptpn6 Cfl1 Ptk2b Mmp9 Mtor Gnb1 Cxcl12 Limk1 Rgs1 Ubqln1 Vps4a Vps4b Grk6 Arrb2 Stat5b Ralb Itch Akt1 Lck Foxo1 Csk P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Hspb1 Ywhaz Mapkapk3 Raf1 Th Tcf3 Mapk14 Etv1 Mapk11 Lsp1 Ywhah Cdc25b Ywhag Ywhae Tsc2 Ywhab Srf Sfn Creb1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Adam10 Fzd1 Csnk2a1 Axin1 Kremen2 Dll1 Ppard Dkk1 Ncstn Aph1b Ctnnb1 Mapk1 Jun Psenen Mapk3 Psen1 Fos Ccnd1 Gsk3b Hnf1a Nedd4 Fbxw11 Crebbp Map3k7 Apc Csnk1a1 Btrc Tle1 Tle5 Dkk2 Notch1 Ctbp1 Ppp2r5d Myc Hdac1 Nlk Lrp6 Wif1 Dvl1 Wnt1 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Perp Bax Itgb4 Fdxr Clca2 Ada Jag1 Abl1 Aen Mdm2 Sp1 Flot2 Tp63 Serpinb5 Ikbkb Gdf15 Vdr Gadd45a Plk1 Shh Prkcd Chuk Cables1 Hbp1 Cdkn2a Egr2 Fas Btrc Cdkn1a Dhrs3 Igfbp3 Traf4 Ogg1 Spata18 Itch Tfap2c Nqo1 Noc2l Gpx2 Evpl Itga3 Ssrp1 Dicer1 Wwp1 Mfge8 Smarcd3 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Ptpn2 Il1b Stat3 Ptpn11 Stat1 Pik3r1 Socs1 Rap1a Ifngr1 Cebpb Pias1 Jak1 Dapk1 Rap1b Mapk1 Camk2a Mapk3 Casp1 Map2k1 Prkcd Crebbp Cbl Camk2d Ifng Mtor Map3k1 Crkl Smad7 Irf1 Pias4 Camk2b Akt1 Ptges2 Camk2g Jak2 Irf9 Map3k11 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Uso1 Kdelr1 Gga3 Ap2a1 Arfip2 Clta Gosr2 Cltb Arfgap1 Pld2 Asap1 Arf1 Cyth2 Cd4 Rac1 Ap2m1 Gbf1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Il1a Sqstm1 Rela Prkci Ube2v1 Il1b Ticam2 Irak3 Erc1 Tab2 Pik3r1 Il1rap Tollip Il1r2 Il1rn Mapk8 Ube2n Jun Irak1 Casp1 Ikbkb Myd88 Ikbkg Irak4 Map2k6 Map3k7 Chuk Traf6 Map3k3 Prkcz Nfkb1 Il1r1 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Gata3 Smarcc1 Nr3c1 Nr1i3 Tsg101 Kmt5b Ncoa2 Ywhah Fkbp5 Ncoa1 Sumo2 Il5 Nr4a1 Pou1f1 Smarcd1 Cga Pck2 Pomc Krt17 Pbx1 Smarcc2 Sfn Egr1 Bglap Gsk3b Sele Crebbp Mapk9 Il13 Ppp5c Mmp1 Cdkn1a Tbx21 Icam1 Mapk10 Mapk11 Irf1 Smarca4 Prkacb Il6 Cdk5 Cdk5r1 Nfkb1 Bax Rela Stat5a Stat1 Spi1 Fkbp4 Mdm2 Mapk8 Mapk1 Afp Jun Mapk3 Prkaca Fos Il2 Il4 Pou2f1 Ifng Csf2 Fgg Mapk14 Stat5b Hdac2 Tbp Prl Hsp90aa1 Hdac1 Akt1 Csn2 Sgk1 Krt14 Tp53 Creb1 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Nras Shc1 Spry2 Src Hgs Egfr Ube2d3 Raf1 Pik3r1 Tsg101 Ptk2 Arhgef7 Egf Sh3kbp1 Grb2 Eps15 Synj1 Sos1 Dnm1 Itsn1 Hras Stambp Usp8 Amph Chmp3 Epn1 Ube2d2 Rab5a Zfyve28 Lrig1 Cbl Pik3cb Sh3gl2 Ube2d1 Cblb Kras E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Tfe3 Hic1 Rbl1 Topbp1 Serpine1 Brca1 Xrcc1 Atm Apaf1 Cdc25a Sp1 Casp7 Ccna2 Kat2a Uxt Tfdp2 Crebbp Ces1d Cdkn2c Tyms Mybl2 Sult2a1 Ranbp1 E2f3 Ces2h Cdk2 Hbp1 Mcm3 Ces4a Dhfr Rb1 Cdkn1a Orc1 E2f5 Ces5a Rrm2 E2f6 Rbbp8 E2f7 Yy1 Wasf1 Cdkn1b Prmt5 Cbx5 Sirt1 Ccne2 Tp73 Ccnd3 Plau Mcl1 Cdkn2a Cdk1 Cdc6 Smarca2 Ccne1 Myc Hdac1 Trim28 Rbl2 Cebpa E2f1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Nfkbia Rela Ube2d3 Chuk Malt1 Atm Traf6 Bcl10 Erc1 Cyld Btrc Xpo1 Ran Tnf Prkca Ripk2 Tnfrsf1a Ikbkb Nfkb1 Birc2 Ikbkg EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Efna5 Fyn TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Shc1 Lat Rap1a Map3k8 Grb2 Prkca Pdpk1 Sos1 Orai1 Hras Stim1 Rassf5 Ikbkb Ikbkg Plcg1 Vav1 Cd3g Cd247 Prf1 Malt1 Cd3d Cd28 Traf6 Cd86 Bcl10 Cd80 Ptprc Grap2 Cd3e Kras Lcp2 Nras Prkcb Prkce Rasgrp1 Prkcq Rasgrp2 Cd8b Cd8a B2m Fyn Zap70 Ptpn6 Cbl Chuk Map3k14 Akt1 Lck Trpv6 Csk REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Rad50 Egfr Xrcc6 Xrcc5 Atm Max Terf2 Ywhae Nr2f2 Sp1 Egf Sap18 Sp3 Ccnd1 Rbbp7 Esr1 Smad3 Irf1 Terf1 Smg6 Tinf2 Parp2 Pot1 Acd Cdkn1b Znfx1 Terf2ip Hnrnpc Pinx1 Nfkb1 Abl1 Mxd1 Ube3a Mapk1 Jun Wt1 Mapk3 Blm Fos Il2 Ifng Hus1 Mtor Rps6kb1 Tgfb1 Rad1 Hdac2 Hsp90aa1 Myc Mre11 Hdac1 Akt1 Tert Nbn E2f1 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Cbx4 Raf1 Cdk6 Myod1 Cebpb Sftpd Ccna2 Gsc Runx2 Ccnd1 Mitf Bglap Ccnd2 Tgfb2 Crebbp Mapk9 Mef2c Ubtf Cdk4 E2f3 Cdk2 Rb1 Cdkn1a Mapk11 Smarca4 Met Smarcb1 Cdkn1b Hdac3 Suv39h1 Brd2 Pax3 Pparg Aatf Rbp2 Atf7 Ckm Sirt1 Dnmt1 Taf1 Spi1 Abl1 Mdm2 Elf1 Jun Ppp2ca Ccnd3 Csf2 Cdkn2a Atf2 Mapk14 Skp2 Tbp Ccne1 Ctbp1 Hdac1 Cebpa E2f1 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Smad2 Smad3 Ppm1a Map3k1 Smad4 Nup153 Ctdspl Tgfbrap1 Ube2i Kpnb1 Pias4 Mapk1 Kpna2 Ctdsp1 Mapk3 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Lep Serpine1 Eno1 Hmox1 Vegfa Tf Ncoa2 Ncoa1 Sp1 Id2 Arnt Tfrc Crebbp Hif1a Smad3 Smad4 Hdac7 Furin Npm1 Nos2 Cxcr4 Gata2 Plin2 Adm Itgb2 Cp Pfkfb3 Nt5e Pgm1 Fech Pkm Aldoa Ets1 Abcb1a Pfkl Rora Edn1 Hk2 Bhlhe41 Igfbp1 Ca9 Jun Gck Fos Cops5 Tff3 Cxcl12 Mcl1 Epo Bhlhe40 Hnf4a Egln3 Cited2 Pgk1 Slc2a1 Abcg2 Akt1 Bnip3 Tert Creb1 Ndrg1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Itgb1 Pik3r1 Rap1a Fyn Map1b Mapk8 Grin2a Mapk8ip1 Arhgef2 Map2k7 Gsk3b Cbl Lrpap1 Vldlr Crkl Nck2 Grin2b Lrp8 Pafah1b1 Dab1 Cdk5 Akt1 Cdk5r1 Itga3 Reln Map3k11 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Map2k4 Cflar Tnfrsf10b Map3k1 Pik3cb Casp8 Chuk Ripk1 Pik3r1 Fadd Smpd1 Mapk8 Mapk1 Dap3 Mapk3 Tnfsf10 Ikbkb Ikbkg Traf2 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Mapk9 Mapk8 Gnb1 Gnal Crh Mapk14 Mapk11 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Shc1 Eif2a Itgb1 Src Ptpn2 Egfr Stat5a Itga1 Stat3 Stat1 Atr Pik3r1 Pdgfrb Stat6 Gab1 Vegfa Pdgfb Kpnb1 Jak3 Pias1 Jak1 Egf Grb2 Kpna2 Sos1 Rab4a Lman1 Crebbp Pik3cb Hgf Stat5b Met Ins2 Eif2ak2 Csf1r Csf1 Insr Ptpn1 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Smurf1 Ppm1a Ctdspl Xiap Bmp7 Zfyve16 Tab2 Ppp1r15a Smurf2 Bambi Mapk1 Ctdsp1 Grem1 Ahsg Sostdc1 Rgma Gsk3b Hjv Chrd Map3k7 Fst Nog Bmpr1a Bmp6 Smad4 Bmp2 Smad6 Chrdl1 Smad7 Ppp1ca Bmpr2 Smad1 Smad9 Bmp4 Smad5 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events Gna14 Gnaq Gnb1 Rock2 Plcb2 Myl2 F2rl2 Gna13 Rock1 Rhoa Gna11 F2 Gna15 FSH%NETPATH%FSH FSH Map2k2 Grk4 Fshb Fshr Akt2 Grk6 Cga HEDGEHOG%NETPATH%HEDGEHOG Hedgehog Prkaca Ctnnb1 Gli1 Kif7 Med6 Gli2 Grk2 Ywhae Ptch1 Sap18 Dyrk1a Sufu Boc Arrb2 Kif27 Med23 Med12 Med1 Ccnb1 Dhh Hhip Ihh Stk36 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor Ar Hdac1 Akt1 Hspb1 Pik3r1 Ptk2 Creb1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor Arrb2 Ar Hdac1 Akt1 Pik3r1 Ptk2 Atf2 Ccne1 Fkbp1a Mapk1 Irf2bp1 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Ube2i Myc Tp53 Skp1 Pdk1 Pard6a Ctnna2 Ctnna1 Dcp1a Rbx1 Eid2 Ube2d3 Ube2d2 Ube2d1 Nup153 Sik1 Btrc Cdc25a Atf3 Jund Pxn Sdc2 Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Tp73 Jun Cops5 Vdr Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Stk11 Hspa8 Map4k1 Ppp1r15a Snw1 Wwtr1 Sparc Cdk6 Smad4 Fnta Cdk4 Cul1 Cdc16 Junb Smad6 Daxx Hnf4a Ing2 Xpo1 Pdpk1 Ctcf Foxo4 Tfdp2 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Zeb1 Gsk3b Rbl2 Zeb2 Anapc10 Smurf1 Crk Pik3r2 Stk11ip Nfyb Nfya Ppm1a Nfyc Prkar1b Hoxa7 Map2k6 Bcar1 Fzr1 Ncoa1 Ap2b1 Runx3 Runx1 Cd44 Runx2 Rb1 Tgfbr3 Prkar2a Trim33 Map2k3 Mef2c Brca1 Zfyve9 Cdkn1a Tgfbr2 TCR%NETPATH%TCR TCR Map2k2 Ctnnb1 Dyrk1a Creb1 Akt1 Pik3r1 Ptk2 Atf2 Mapk1 Mapk3 Pxn Gsk3b Crk Pik3r2 Pard3 Prkd1 Prkd2 Eno2 Crkl Cd2ap Acta1 Plcg1 Cblb Plcg2 Ly9 Wipf1 Prkcd Itsn2 Rasgrp1 Rasgrp2 Vasp Arhgef7 Arhgef6 Rasa1 Txk Arhgef2 Unc119 Cabin1 Rps6kb1 Pttg1ip Pik3ap1 Bcl10 Grap Lnpep Lyn Egr1 Nfkbib Fyb1 Tfrc Pik3c2b Cgn Homer3 Nfkbia Crebbp Kirrel1 Slamf6 Cyfip1 Grb2 Ada Ikbkb Itk Gdi2 Enah Tsg101 Dyrk1b Cltc Cd28 Nfkb1 Jak3 Vav3 Rap1a Diaph1 Syk Skap2 Skap1 Gab2 Vav1 Vav2 Bdh1 Ldhb Tuba4a Zdhhc17 Golga5 Ctla4 Cd3g Actr10 Cd3e Cd3d Dusp3 Pak1 Nfam1 Caskin2 Cct8 Dpysl2 Git2 Ahcy Grap2 Mpzl1 Map2k1 Hnrnph3 Nedd9 Stat1 Dbnl Sh2d3c Mapk8 Tuba1a Sla Map3k8 R3hcc1l Sit1 Dgka Sdcbp Cd86 G6pd Cd84 Sh2d2a Cd82 Snrnp70 Cd80 Lax1 Hsp90ab1 Rela Mtmr10 Dok1 Dok2 Hgs Stk39 Flnb Anxa2 Raf1 Inpp5d Shc1 Stk4 Acly Ripk2 Elmo1 Prp4k Bmf Ptprc Tubb5 Ppp3cb Eprs1 Ptpra Pstpip1 Acbd6 Fer Ogn Cdk1 Lat Itpr1 Zap70 Wdr1 Arhgdib Ddx3x Hdac7 Acp1 Pgm1 Nck1 Nfatc2 Stam2 Anxa11 Msl2 Adam9 Dnm2 Epha3 Pkm Lck Lcp2 Sos1 Ywhaz Lpxn Eif3m Atp1a1 Src Atp1a3 Ptpn6 Trim25 Ptpn3 Cbl Cebpb Dock2 Cd2 Muc1 Cd4 Trat1 Cd5 Cd7 Ptpn11 Ptpn12 Mapk14 Arhgap35 Dnajb1 Ptk2b Sh3bp2 Tec Khdrbs1 Ptpn22 Chuk Ran Mapk11 LEPTIN%NETPATH%LEPTIN Leptin Rps6ka2 Acacb Igf1r Stat1 Rps6kb1 Mapk8 Src Gsk3b Nfkbia Grb2 Ikbkb Ncoa1 Shc1 Runx2 Khdrbs1 Jak3 Chuk Crp Erbb2 Irs1 Pde3a Eif4ebp1 Esr1 Socs7 Prkaa1 Prkaa2 Gnaq Akt1 Slc2a4 Fyn Jak1 Ptk2 Nos3 Rps6 Plcg1 Cfl2 Mapk1 Plcg2 Egfr Eif4e Gsk3a Cdk5 Lep Limk1 Prkce KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor Socs1 Mitf Socs5 Socs4 Matk Stat1 Socs6 Ptpru Mapk8 Gys1 Csf2rb Jak2 Sh3kbp1 Mad2l1 Fgr Gsk3b Hck Prkcb Rps6ka1 Kit Tnfrsf10b Crk Prkca Il7r Spred1 Ezr Spred2 Grb7 Rela Mtor Epor Mapk12 Yes1 Kitlg Rdx Msn Stat5a Raf1 Stat5b Inpp5d Fes Cdk2 Hras Akt1 Crkl Pik3r1 Atf2 Cblb Mapk1 Wipf1 Rasa1 Rps6kb1 Sos1 Grap Src Ptpn11 Mapk14 Cltc Tec Jak3 Jun Eif4ebp1 Fyn Rps6 BCR%NETPATH%BCR BCR Pdpk1 Nedd9 Foxo3 Stat1 Fos Gsk3b Hck Prkcb Rps6ka1 Crk Pik3r2 Rela Dok1 Bcar1 Ctnnb1 Shc1 Cdk2 Rb1 Tcl1a Cd72 Stap1 Elk1 Sla2 Chst15 Bank1 Nfatc3 Cd22 Creb1 Malt1 Prkd1 Cycs Akt1 Plekha1 Hcls1 Crkl Prkcq Gtf2i Ptk2 Atf2 Lat2 Plcg1 Rasgrp3 Itpr1 Zap70 Blnk Mapk1 Btk Pip4k2b Pip4k2c Prkcd Pip4k2a Cd79b Ptpn18 Nck1 Ccl4 Nfatc2 Pik3cg Casp7 Mapkapk2 Rasa1 Casp9 Sh2b2 Ifitm1 Fcgr2b Cdk7 Lck Rps6kb1 Bcl6 Btla Sos1 Bax Bcl10 Stat3 Pip5k1c Hnrnpk Lyn Pip5k1b Itpr2 Ptpn6 Grb2 Ikbkb Itk Mapk14 Sh3bp2 Tec Chuk Jun Vav1 Eif4ebp1 Map4k1 Fyn Rps6 Gsk3a Junb TNFALPHA%NETPATH%TNFALPHA TNFalpha G3bp2 Dcaf7 Cops3 Nfkbie Nlrp4 Kpna6 Mcc Kpna3 Stat1 Kpna2 Cdk9 Mapk8 Zbtb17 Ccnt1 Cyba Map3k8 Diablo Bcl3 Rel Tab2 Traf7 Traf4 Mcm7 Pfdn2 Akt2 Traf6 Faf1 Birc3 Birc2 Ikbkg Hsp90ab1 Csnk2a1 Tnfrsf8 Ikbke Dok1 Ywhah Ywhag Mark2 Psmd12 Tnfrsf1b Hdac2 Smarcb1 Ywhab Psmd13 Alpl Ywhae Rasal2 Akap8 Psmb5 Rpl8l1 Ppp6c Gab1 Bcl2l1 Rack1 Creb1 Fkbp5 Rps6ka5 Hdac1 Smarca4 Akt1 Fadd Hspb1 Mcm5 Smpd3 Ptk2 Tnip2 Psmc2 Psmc1 Psmc3 Mapk1 Polr2h Pdcd2 Ddx3x Nsmaf Map2k5 Itch Zfand5 Mapk3 Cflar Ube2i Bid Trpc4ap Psmd7 Skp1 Psmd6 Pdk1 Fancd2 Psmd3 Psmd2 Casp3 Romo1 Elp1 Sos1 Psmd1 Ube2d3 Ywhaz Casp2 Ube2d2 Trim32 Spag9 Usp11 Src Glb1 Btrc Smarcc2 Prc1 Smarcc1 Rnf25 Pkn1 Lrpprc Map3k11 Mtif2 Trap1 Ptpn11 Mapk14 Jun Irs1 Cav1 Egfr Cul1 Junb Foxo1 Prkca Map2k6 Stat5a Rb1 Gtf2i Casp7 Mapkapk2 Bax Rpl4 Txn1 Mapk9 Nkiras1 Brinp1 Nr2c2 Nkiras2 Nfkbia Erbb3 Crebbp Tbkbp1 Trib3 Rps11 Tnf Grb2 Hsp90aa1 Fbl Ppp1r12a Rpl30 Unc5cl Tbk1 Dpf2 Tax1bp1 Kcnq1 Polr1b Nfkb1 Polr1c Txnip Polr1a Usp2 Xiap Polr1e Fbxw11 Tank Map3k3 Actl6a Map3k2 Rxra Smarce1 Polr2sl1 Tifa Flna Cdc37 Rffl Inpp5e Rasa3 Nfkbiz Papola Pak1 Glg1 Bag4 Ripk3 Cradd ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Fos Prkca Pik3r2 Mtor Ywhah Yes1 Ywhab Shc1 Ywhae Gab1 Ar Akt1 Pik3r1 Ptk2 Mapk1 Prkcd Mapk3 Pik3cg Casp3 Ywhaz Src Clca1 Irs2 Rpsa Rhoa Grb2 Rac1 Plec Ptpn11 Dsp Lama5 Mapk14 Cd151 Itgb4 Lama2 Lama3 Mst1r Mylk3 Met Pik3r3 Tp73 Col17a1 Jun Itga6 Ntn1 Erbb2 Ephb2 Irs1 Lamb2 Lamb3 Eif4ebp1 Sfn Lamb1 Pik3cb Pik3cd Rtkn Bad Fyn Smad2 Smad3 Eif6 Lamc1 Vim Egfr Eif4e Pak1 WNT%NETPATH%WNT Wnt Ppp2ca Sfrp1 Daam1 Dkk1 Mesd Pax2 Prkcg Frzb Dixdc1 Chd7 Mapk8 Axin1 Ror1 Lef1 Lrp1 Arhgef4 Csnk1a1 Nlk Prkcb Lrp5 Gpc3 Dvl3 Wnt2 Prkca Wnt1 Tcf7l2 Wnt3 Fzd1 Jup Fzd5 Fzd4 Fzd6 Kremen1 Yes1 Fzd9 Mark2 Smad1 Prkaca Pin1 Tcf4 Ywhab Arrb2 Akt1 Prkcd Nfatc2 Pip5k1b Rhoa Rac1 Jun Ccnd1 Cdk6 Map3k7 Ctbp1 Wnt5a Cdh1 Pi4k2a Ppp1ca Sfrp2 IL6%NETPATH%IL6 IL6 Map2k1 Foxo4 Foxo3 Stat1 Foxo1 Cdk9 Mapk8 Fos Fgr Gsk3b Hck Nlk Map2k2 Pik3r2 Map2k6 Ncoa1 Socs3 Stat5a Map3k4 Stat5b Pias3 Cd40 Shc1 Sgk1 Rb1 Il6st Il6 Il6r Bmx Eif2a Gab1 Map2k4 Ar Hdac1 Akt1 Hspb1 Pik3r1 Plcg1 Mapk1 Btk Prkcd Mapk3 Rps6kb1 Stat3 Lyn Cbl Erbb3 Crebbp Grb2 Hsp90aa1 Rac1 Ptpn11 Mapk14 Ptk2b Nfkb1 Jun Erbb2 Gab2 Vav1 Eif4ebp1 Bad Fyn Jak1 Map3k7 Eif4e Daxx TSH%NETPATH%TSH TSH Igf1r Raf1 Map2k3 Gna12 Gna11 Atp1a1 Creb1 Gnao1 Gna13 Tshr Hspa5 Gnaq Canx Gnai2 Gnai1 Calr Scrib Gnai3 Ikbkb Map2k6 Lep Mapk3 EGFR1%NETPATH%EGFR1 EGFR1 Map2k2 Ywhab Dyrk1a Gab1 Creb1 Rps6ka5 Hdac1 Pik3r1 Ptk2 Mapk1 Itch Myc Tp53 Jund Irs2 Dab2 Rhoa Rac1 Plec Dsp Itgb4 Sp1 Met Pik3r3 Col17a1 Jun Ephb2 Cav1 Pik3cb Stk11 Pik3cd Bad Smad2 Smad3 Vim Ctbp1 Cdh1 Pdpk1 Foxo4 Prkcg Zfyve16 Foxo1 Fos Arhgef4 Gsk3b Crk Pik3r2 Jup Ap2b1 Socs3 Map3k4 Pias3 Map2k3 Pard3 Prkd1 Crkl Plcg1 Scrib Cblb App Plcg2 Spart Atf1 Myl12b Prkcd Il17rd Itsn2 Mprip Nedd4 Eno1 Vasp Nectin1 Arhgef7 Rps10 Elk4 Gja1 Tfg Tns4 Scamp3 Tns2 Rps6kb1 Tns1 Pttg1ip Ralb Krt8 Otud6b Cblc Araf Lyn Krt7 Frs2 Frs3 Phlpp1 Tfrc Actb Pik3c2b Actr2 Actr3 Arhgap5 Prkci Arap1 Kirrel1 Zdhhc5 Tln1 Rin1 Pfn1 S100a10 Snca Arhgef5 Hnrnpr Sdc4 Sdc3 Dyrk1b Insr Cltc Pitpna Stam Nfkb1 Flot1 Atp5f1c Errfi1 Usp6nl Myo6 Slc5a5 Snx5 Tollip Smu1 Vav1 Etl4 Vav2 Sdc1 Antxr1 Hip1 Arf4 Braf Adam17 Ptprr Clta Dcbld2 Ptprf Git1 Laptm4a Pak1 Cdv3 Plekha6 Caskin2 Cyld Anks1a Ahnak Git2 Mink1 Rplp0 Actn1 Mpzl1 Snx33 Map2k1 Actn4 Tkt Nedd9 Baiap2l1 Plscr1 Gprc5a Rbck1 Mapk8 Htt Aldoa Map2k7 Appl2 Stx4 Rps2 Limd1 Sdcbp Cstb Inppl1 Krt18 Pygb Gsn Pdzd11 Krt17 Ap2s1 Mcf2 Racgap1 Rela Eps15l1 Esyt1 Dok1 Eppk1 Dok2 Cttn Axl Ctnnd1 Flnb Ensa Stat2 Raf1 Pkn2 Frk Hipk2 Tjp2 Map3k14 Hipk3 Eef1a2 Prp4k Grb14 Rictor Grb10 Phpt1 Stip1 Cdh3 Ptpra Cdh2 Plekhn1 Cavin1 Cavin2 Tom1 Cdk1 Cc2d1a C8h11orf52 Cfl1 Prkx Magi1 Hat1 Ddx3x Ap2a1 Pkp2 Acp1 Hnrnpdl Anxa4 Nck1 Ldlr Pkp3 Anxa1 Vcl Cysrt1 Adam9 Stambp Pld1 Map4k5 Pkm Lpp Lck Rab5a Pld2 Ppp1r14b Ywhaz Itga3 Pdgfrb Elmo2 Atp1a1 Abl2 Slc38a2 Dynll1 Ptpn6 Tom1l2 Efnb2 Ptpre Cav2 Cebpb Tnk2 Ripk1 Sirpa Ralgds Dlg3 Alb Bcl2 Crim1 Ddx6 Ptpn12 Pdlim1 Mapk14 S100a11l1 Arhgap35 Sh3bgrl Afap1l2 Ptk2b Rbm3 Tgif1 Sfpq Khdrbs1 Nck2 Dapp1 Iqgap1 Asap1 Slc12a7 Erbb2 Mt-co2 Baiap2 Sh3gl3 Eif4ebp1 Lsr Epha1 Prkaa1 Epha2 Prkaa2 Epn2 Epn1 Dyrk4 Epha4 Fyn Jak1 Rps6ka3 Itgb1 Nos3 Epn3 Dyrk3 Egfr Usp31 Elf3 Gsk3a Klf11 Cdk5 Aplp2 Myh9 Dsg2 Ctnnal1 Rps6ka2 Cd59b Tnip1 Wbp2 Socs1 Mvp Trim29 Eif4g1 Dock1 Ephb1 Cebpa Ephb3 Phldb2 Ptpn1 Jak2 Slitrk6 Sh3kbp1 Rgs16 Csk Kras Mta2 Arhgap32 Rps6ka1 Snrpd2 Kit Egf Tagln2 Prkca Spry2 Rbbp7 Spry1 Pten Reps2 Grb7 Ralbp1 Mtor Bcar3 Spry4 Pebp1 Ptpn23 Slc25a5 Hspe1 Arhgap42 Stat5a Zpr1 Stat5b Cdk2 Hras Elk1 Ptpn18 Pik3cg Casp9 Mapk9 Erbb3 Rpl30 Map3k3 ID%NETPATH%ID ID Psmd4 Elk4 Raf1 Fhl2 Map2k1 Elk3 Cdk2 Rb1 Rbl1 Id3 Hes1 Smurf2 Elk1 Tcf3 Myf5 Rbl2 Map2k2 Atf3 Smad3 Tcf7l2 Mapk1 Mapk3 IL9%NETPATH%IL9 IL9 Stat5a Stat5b Mapk1 Kat5 Stat6 Il9r Mapk3 IL3%NETPATH%IL3 IL3 Ppp2ca Map2k1 Foxo1 Csf2rb Ywhaz Lyn Gsk3b Ptpn6 Prkcb Crk Prkca Pik3r2 Dok1 Prkaca Socs3 Inpp5d Ywhab Fes Shc1 Nfkb1 Hras Ptprc Gab1 Bcl2l1 Gab2 Rack1 Socs2 Creb1 Bcl2l11 Kcnip3 Pik3cd Rxra Rara Slc2a1 Bad Crkl Pik3r1 Gata2 Ptk2 Mapk1 Atf1 Gsk3a IL5%NETPATH%IL5 IL5 Pik3cg Socs1 Dnm2 Unc119 Foxo3 Stat1 Bax Sos1 Stat3 Ywhaz Lyn Gsk3b Hck Sdcbp Map2k2 Rps6ka1 Cbl Nfkbia Grb2 Ptpn11 Mapk14 Ctnnb1 Ptk2b Stat5a Stat5b Raf1 Shc1 Nfkb1 Hras Jun Elk1 Syk Rack1 Hcls1 Crkl Alox5 Jak1 Atf2 Pla2g4a Il5 Sox4 Il5ra Gsk3a Prkcd IL4%NETPATH%IL4 IL4 Snd1 Il2rg Socs1 Rasa1 Cebpa Rps6kb1 Mapk8 Stat3 Jak2 Ptpn6 Cbl Cebpb Nfkbia Crebbp Irs2 Ikbkb Ptpn11 Mapk14 Inpp5d Shc1 Stam Nfkb1 Cd40 Chuk Mapk11 Elk1 Syk Pik3cd Akt1 Bad Jak1 Ptk2 Atf2 Mapk1 Plcg2 Spi1 Il13 Ets1 Il4 Prkcd Grk3 Cxcr4 Mapk3 Il13ra1 IL-7%NETPATH%IL-7 IL-7 Il2rg Il7 Map2k1 Foxo3 Stat1 Foxo1 Stat3 Gsk3b Map2k2 Il7r Irs2 Stat5a Stat5b Shc1 Stam Jak3 Irs1 Akt1 Bad Fyn Pik3r1 Cblb Mapk1 Gsk3a Mapk3 NOTCH%NETPATH%NOTCH Notch Ncstn Skp1 Aph1b Ncor2 Fhl1 Dll3 Dll4 Maml1 Rbx1 Ring1 Maml2 Stat3 Lef1 Furin Jak2 Ccn3 Skp2 Src Jag2 Gsk3b Hes6 Maml3 Cirsr Notch4 Yy1 Psenen Notch2 Lfng Psen2 Rela Smad1 Hdac2 Nfkb1 Hes1 Tcf3 Akt1 Snw1 Pik3r1 Smad3 App Mapk1 Cul1 Mapk3 IL2%NETPATH%IL2 IL2 Map2k1 Foxo3 Mapk8 Map2k2 Crk Pik3r2 Rela Mtor Socs3 Stat5a Raf1 Stat5b Shc1 Cdk2 Sgk1 Elk1 Creb1 Akt1 Crkl Pik3r1 Atf2 Ccne1 Mapk1 Ets1 Mapk3 Pik3cg Stam2 Il2rg Lck Sos1 Lyn Ptpn6 Cbl Il15 Irs2 Stat4 Il2ra Grb2 Ybx1 Hsp90aa1 Bcl2 Ets2 Ptpn11 Plcb1 Tert Mapk14 Nr3c1 Itm2b Eif3b Ptk2b Il2 Prkcz Nfkb1 Stam Nmi Jak3 Vil1 Pik3r3 Mknk1 Jun Irs1 Gab2 Vav1 Eif4ebp1 Pik3cb Pik3cd Fyn Jak1 Rps6 Eif4e TSLP%NETPATH%TSLP TSLP Stat5a Stat5b Map2k1 Nfkb1 Stat1 Nfkb2 Mapk8 Stat3 Stat6 Mapk9 Akt1 Nfkbia Mapk1 Stat4 Eif4e Rela Mapk14 Mapk3 RANKL%NETPATH%RANKL RANKL Mitf Nfkb1 Chuk Nfkb2 Traf3 Mapk8 Tnfsf11 Atp6v1e1 Sqstm1 Tnfrsf11b Trem2 Rel Traf2 Tab2 Traf6 Ptk2 Map3k7 Spi1 Mapk14 IL1%NETPATH%IL1 IL1 Elp1 Mapk8 Rel Tab2 Mapk9 Traf6 Pik3r2 Nfkbia Rela Ikbkb Map2k6 Dok1 Mapk14 Nfkb1 Rb1 Chuk Jun Map3k14 Map2k3 Ppp6c Tollip Peli1 Map3k2 Ube2v1 Ube2n Akt1 Irak4 Irak3 Pik3r1 Irak2 Atf2 Pla2g4a Irak1 Myd88 Sod1 Mapk1 Il1a Fbxw5 Il1b Peli2 Il1r2 Il1r1 Mapk3 Il1rn ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Ilvbl Bcat1 Bcat2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Taldo1 Tkt Hk2 Rpia Gpi ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Dhfr Mthfd1l Tyms Mtr Mthfd2 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Hk2 Gale Galt Aldob Aldoc Aldoa Khk P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Srf Mef2d Elk1 Map3k7 Map2k6 Map3k4 Hspb1 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Eef2k Eif4e Map2k4 Rps6ka5 Mef2c Mknk2 Mknk1 Tab2 Map3k10 Il1r1 Mapk11 Atf1 Traf6 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Prkcz Pik3cb Pik3cd Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Hras Hspb1 Mapkapk3 Mapk14 Mapkapk2 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Rac2 Akt1 Rac1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Pik3cb Nos3 Il10 Il11 Ikbkb Spi1 Stat6 Il15 Irs1 Cxcr1 Cxcr2 Stat4 Il13 Il18 Il2ra Irs2 Sla2 Mapk6 Elk3 Elk4 Pdpk1 Myc Akt3 Akt2 Jak3 Foxo3 Il13ra1 Il13ra2 Il20ra Fos Il23a Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Il5ra Sos1 Il6st Shc1 Il10rb Il3ra Il10ra Mtor Il2 Il4 Il6 Il5 Il7 Il9 Il6r Il21 Il12rb2 Il11ra1 Srf Il4r Mapk15 Elk1 Spic Il1a Stat5a Stat5b Stat3 Stat2 Stat1 Chuk Cdkn1a Mapkapk2 Cdkn1b Mknk2 Mknk1 Mapk1 Braf Mapk3 Akt1 Araf Nras Raf1 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Eprs1 Cpox Urod Ppox Alad Qars1 Hmbs Fech NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Cacna1g Cacna1c Epb41l2 Chrnb4 Clic6 Ppp1r1b Kcnk3 Chrnb3 Chrnb2 Epb41l1 Slc18a2 Adcy2 Drd2 Ppp1ca Drd4 Prkaca Kcnk9 Chrna3 Epb41 Chrna6 Chrna5 Gnb1 Chrna4 Flna Gnai1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Pmvk Ggps1 Hmgcr Mvd Fdft1 Lss Sqle Fdps Hmgcs1 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway Slc17a8 Slc17a6 Vamp8 Vamp1 Vamp3 Gria4 Vamp2 Gria3 Snap29 Gria2 Snap25 Grik5 Snap23 Stx19 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Stx11 Grin2b Grin2a Shank1 Shank3 Grm2 Slc1a1 Slc1a3 Slc1a2 Slc1a7 Grin1 Slc1a6 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Ccnd2 Ccnd3 Ccne1 Rpa3 Cinp P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Pik3cb Pik3cd Pik3c2b Pik3c2a Mapk12 Mapk13 Mapk14 Cdkn1a Hras Mapk11 Ccne1 Ccng1 Ctnnb1 Pdpk1 Kras Pik3c3 Tp53 Akt3 Tp73 Akt2 Rb1 Ppp2cb Akt1 Ppp2ca Pten Pik3c2g Rbl1 Siah1 Cdk2 Pik3r5 Atm Tp63 Atr Nras Pik3r1 Pik3r2 Pik3r3 Pik3cg THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Prkcz Plcz1 Plce1 Gnb4 Gnb3 Gnb5 Itpr3 Gng12 Itpr2 Itpr1 Plcg1 Prkcq Plcg2 Gnb1 Prkcg Prkch Prkci Prkcb Plcb4 Gna11 Plcb3 Prkcd Gng10 Gna14 Prkce Plcd1 Prkca Plcd4 Plcb2 Plcb1 Hrh1 Gng3 Gng5 Plcl1 Gnaq Gng7 Gng8 Gngt2 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Prkaca Itpr1 Prkar1b Prkx Prkacb Grik5 Grina Grm1 Grm5 Prkcb Plcb4 Grik1 Gna11 Grin2d Grin2c Grin2b Grin2a Gnaq Grin1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Elk1 Map2k6 Mapk12 Stat1 Mapk13 Mapk14 Eef2k Map2k4 Txn1 Mapk9 Mef2c Jun Mknk2 Mapk8 Mknk1 Max Ddit3 Map2k3 Bcl2 Mapk11 Pla2g4a Myc 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gnb4 Gnb3 Gnb5 Gng12 Prkx Prkacb Gnao1 Adcy7 Prkar2a Kcnk3 Prkar2b Htr1d Htr1f Gnai2 Htr1b Adcy2 Htr1a Gng11 Gnai3 Prkaca Kcnk9 Gnb1 Gnai1 Gng10 Gng3 Gng5 Gng7 Gng8 Gngt2 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Prkcz Plcz1 Plce1 Gnb4 Gnb3 Gnb5 Gng12 Oxtr Plcg1 Prkcq Plcg2 Gnb1 Prkcg Prkch Prkci Prkcb Plcb4 Gna11 Plcb3 Prkcd Gng10 Gna14 Prkce Plcd1 Prkca Plcd4 Plcb2 Plcb1 Gng3 Gng5 Plcl1 Gnaq Gng7 Gng8 Gngt2 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Gnb4 Htr4 Gnb3 Gnal Gnb5 Gng12 Gnb1 Gng10 Adcy7 Gng3 Gng5 Gng7 Gng8 Gngt2 Adcy2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Gnb4 Gnb3 Prkar1b Prkacb Cacna1g Gnao1 Adcy7 Prkar2a Prkar2b Adcy2 Gng11 Gnai3 Prkaca Cacna1a Cacna1b Gabbr1 Gabbr2 Adcy4 Gnb1 Adcy1 Adcy8 Adcy5 Gnai1 Adcy6 Kcnj3 Gng3 Gng5 Gng7 Gng8 Gngt2 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Ube2g2 Ube2g1 Ube2l6 Ube2a Atg7 Sae1 Ube2l3 Ube2t Ube2s Ube2v2 Ube2k Uba6 Ube2d2b Ube2n Ube2c Ube2b Uba1 Ube2d3 Uba2 Ube2e3 Uba3 Ube2d2 Ube2d1 Ube2e2 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway App Erbb4 Nectin1 Apbb3 Trpc6 Afdn Trpc5 Cdh3 Trpc7 Wnt5a Kat5 Trpc1 Cdh1 Trpc4 Wnt5b Wnt9a Kat7 Wnt9b Wnt10a Bace2 Wnt10b Bace1 Ctnnb1 Acta1 Actb Actr2 Notch4 Ern1 Psenen Notch1 Notch2 Notch3 Psen1 Wnt8b Wnt8a Psen2 Gsk3b Fstl1 Wnt16 Wnt11 Lef1 Ncstn Aph1b Lrp1 Lrp6 Lrp2 Lrp3 Lrp4 Lrp5 Wnt6 Rbpjl Wnt7b Wnt3a Dvl1 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Actg1 Wnt4 Cd44 Actg2 Wnt3 Tcf7l2 Fzd1 Actc1 Actbl2 Fzd2 Fzd5 Trim3 Jup Fzd4 Fzd6 Fzd9 Fzd8 Wnt2b 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh1b1 Maoa Aldh1a2 Aldh1a1 Maob Aldh3a2 Aldh1a3 Aldh2 Aldh3a1 Aldh16a1 Aldh8a1 Aldh7a1 Aldh9a1 Aldh1l2 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Mdm2 Tp73 Mdm4 Tp63 Tp53 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Ilvbl Bcat1 Bcat2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss2 Acss3 Acss1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Pank3 Pank4 Pank1 Dcakd METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Ireb2 Aco1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Pik3cb Pik3cd Map2k2 Map2k1 Hras Ikbkb Fos Sos1 Itpr3 Mapk12 Itpr2 Itpr1 Mapk13 Chuk Mapk14 Mapk9 Jun Mapk8 Mapk11 Mapk1 Mapk3 Rac2 Rac1 Araf Plcg2 Nfkbil1 Cd22 Vav3 Nras Syk Prkcb Vav1 Vav2 Map3k3 Prkcd Map3k2 Blnk Btk Raf1 Cd79b Ptpn6 Lyn Ptprc Ppp3ca Ppp3cb Nfkbia Grb2 Mapk10 Pik3cg P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Tsc1 Akt3 Tp73 Igbp1 Akt2 Ppp2cb Prkaa1 Ppp2ca Prkab2 Akt1 Prkaa2 Rps6kb1 Prkab1 Prkag1 Tp63 Eif4ebp1 Tsc2 Tp53 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Plcb3 Plcb2 Plcb1 Dagla Lpl Pla1a MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Gmppb Gmppa Pmm2 Gmds Pmm1 Mpi MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrnp40 Zrsr2 Prpf3 Snrpb2 Snrpa HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Akt3 Akt2 Akt1 Txn1 Mtor Rorc Arnt Txn2 Crebbp Egln2 Egln3 Vhl Hif1a THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Taf6 Gtf2e1 Taf2 Prkar1b Prkar2a Crebbp Prkar2b Gtf2a1l Polr2c Taf1c Taf9 Creb3l3 Creb3l4 Polr2h Polr2e Creb3l1 Polr2f Ttf2 Creb3l2 Ttf1 Taf9b Taf11 Gtf2h1 Gtf2f2 Gtf2h4 Psmc3ip Gtf2f1 Brf2 Tbp Brf1 Tbpl2 Tbpl1 Creb5 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Polr2sl1 Taf8 Taf7 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Gnai3 Gnb4 Oprd1 Gnb3 Pomc Gnb5 Gng12 Gnb1 Gnai1 Gng10 Gnao1 Adcy7 Gng3 Gng5 Gng7 Gnai2 Gng8 Gngt2 Adcy2 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b2 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt1 Gfpt2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Avp Oxt GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn Glud1 UNTITLED%PANTHER PATHWAY%P00019 untitled Prkcz Nos3 Map2k2 Map2k1 Akt3 Akt2 Plcb4 Gna11 Plcb3 Gna14 Plcb2 Plcb1 Gnaq Itpr3 Itpr2 Itpr1 Prkar1b Prkacb Ednrb Ednra Adcy3 Edn1 Edn2 Edn3 Adcy10 Gucy1b1 Prkg2 Gucy1a1 Gucy1a2 Adcy7 Mapk1 Prkar2a Pla2g4a Prkar2b Adcy2 Mapk3 Akt1 Prkaca Gnal Araf Prkcq Adcy4 Adcy1 Prkcg Adcy8 Prkch Adcy5 Prkci Adcy6 Prkcb Prkcd Prkce Prkca Raf1 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Dhfr Tyms Gch1 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Prkcz Plcz1 Plce1 Gnb4 Gnb3 Gnb5 Gng12 Htr2a Htr2c Htr2b Gng11 Plcg1 Prkcq Plcg2 Gnb1 Prkcg Prkch Prkci Prkcb Plcb4 Gna11 Plcb3 Prkcd Gng10 Gna14 Prkce Plcd1 Prkca Plcd4 Plcb2 Plcb1 Gng3 Gng5 Plcl1 Gnaq Gng7 Gng8 Gngt2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Elmo1 Itga2 Pik3cb Pik3cd Itga10 Col4a3 Arpc3 Col4a1 Pik3c2b Cav1 Pik3c2a Arpc2 Ptk2 Col4a2 Map2k2 Col8a1 Col4a5 Map2k1 Arpc5 Hras Parvb Parva Rap2b Col16a1 Arf1 Col12a1 Itgax Ilk Itgav Rnd2 Rhoc Rnd3 Rhoa Rnd1 Rhob Mapk6 Itgam Asap1 Arhgap10 Actb Itgal Rap1a Col3a1 Rap1b Itgad Itgb8 Itgb6 Itgb7 Itga2b Itgb1 Actn2 Itgb4 Rras Itgb2 Actn1 Actn4 Crk Sos1 Arf6 Arhgap26 Shc1 Col15a1 Col11a1 Col11a2 Src Dock1 Bcar1 Dnajc27 Lamb2 Lamb3 Ptpn12 Fyn Csk Lamb1 Col2a1 Col27a1 Actg1 Col6a2 Ptk2b Lims2 Lamc3 Lamc1 Actbl2 Flna Map3k3 Map3k2 Mapk10 Map3k4 Mapk13 Map2k4 Mapk9 Mapk8 Map2k3 Braf Col14a1 Itgbl1 Crkl Pik3c3 Mapk3 Arfgap1 Col1a2 Col5a2 Rac2 Col5a3 Col5a1 Rac1 Dmbt1 Col9a2 Araf Col9a1 Arpc1b Lama5 Arpc1a Lama1 Lama2 Nras Lama3 Lama4 Flnb Tln1 Vcl Vasp Col17a1 Col13a1 Raf1 Fn1 Itga7 Pik3r1 Itga8 Pik3r2 Arl1 Pik3r3 Itga5 Itga6 Itga9 Pxn Itga3 Itga4 Elmo2 Itga1 Pik3cg PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Pik3cb Pik3cd Map2k2 Map2k1 Hras Ikbkb Stat6 Stat4 Mapk6 Elk4 Arhgap10 Pdpk1 Myc Akt2 Jak3 Fos Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Arhgap26 Shc1 Mapk15 Stat5a Ehf Stat5b Srgap1 Stat3 Srgap3 Stat2 Rab11b Stat1 Arhgap5 Chuk Arhgap4 Erf Erg Arhgap9 Shc3 Rasa2 Rasa1 Pdgfrb Pdgfra Pdgfa Pdgfrl Pdgfb Grap Fli1 Rps6kc1 Fev Gabpa Nck2 Jak2 Jak1 Nck1 Arhgap15 Arhgap12 Gab1 Gab2 Etv3 Spdef Elf1 Elf2 Gsk3a Elf3 Elf4 Elf5 Ophn1 Usf2 Vav3 Grap2 Elp1 Vav1 Rerg Vav2 Nin Pkn2 Map3k2 Ninl Arhgap42 Grb2 Mapk10 Rps6kb1 Pik3r5 Srf Elk1 Map3k4 Itpr3 Itpr2 Itpr1 Mapkapk2 Rps6ka5 Jun Mknk2 Mapk8 Mknk1 Mapk1 Braf Ets1 Pik3c3 Mapk3 Plcg1 Araf Plcg2 Nras Arhgap1 Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 Arhgap8 Shc2 Pik3cg NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Myh9 Myh4 Myh6 Myh7 Myo1c Myo1b Myo1e Myo1d Myo5c Myo5b Myo1a Myh11 Myo1g Myo1f Myh10 Plekhh3 Myh7b Myo6 Myo18b Myo5a Myo9a Slc5a7 Chrnd Chrne Chrng Chrna2 Chrna1 Myo10 Chrna9 Acta1 Myo15a Actb Myo16 Myo19 Actg1 Actg2 Actc1 Actbl2 Chrnb4 Chrnb3 Chrnb2 Chrna3 Chrna6 Chrna5 Chrna4 Slc44a3 Actr1a Myo3b Chrnb1 Myo7a Slc18a3 Myo7b Slc6a8 Chrna10 Myh2 Myh3 Myh8 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Stat6 Jak3 Stat5a Stat5b Stat4 Stat3 Stat1 Jak2 Jak1 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Phgdh Psph Psat1 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Pik3cb Pik3cd Pik3c2b Pik3c2a Ntn1 Rac2 Ntn3 Nfatc4 Rac1 Nfatc3 Nfatc2 Plcg1 Ablim1 Dcc Plcg2 Ntng1 Pik3r5 Unc5b Unc5d Unc5c Vasp Pik3r1 Pik3r2 Pik3r3 Pik3cg ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Slc6a20a Slc6a16 Slc18a1 Slc6a2 Slc6a3 Slc6a19 Slc6a18 Slc18a2 Slc6a15 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Ugt2b7 Fmo3 Cyp2a3 Ugt1a2 Ugt1a3 Inmt Ugt1a5 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mtr Mat2a Mat1a CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Myh9 Myh4 Myh6 Myh7 Arpc3 Arpc2 Myh11 Arpc5 Myh10 Myh7b Rhoc Acta1 Actb Diaph2 Diaph1 Tubb2b Actg1 Tubb2a Cfl1 Cfl2 Actg2 Mylk2 Pfn1 Mylk3 Pfn3 Actc1 Pfn2 Actbl2 Stmn1 Pak1 Pak6 Stmn4 Pak3 Pak2 Pak5 Pak4 Tubb5 Tubb6 Tubb3 Mylk Limk1 Arpc4 Rock2 Tubb4b Rock1 Rac2 Rac1 Arpc1b Arpc1a Myo3b Myh2 Myh3 Myh8 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Elk1 Rps6kb1 Map2k2 Map2k1 Rps6ka5 Rasa1 Irs1 Map2k3 Mapk1 Irs2 Ins2 Insr Igf2r Igf2 Igf1 Insrr Mapk3 Igf1r Fos Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Raf1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Ifngr2 Ifng Ifngr1 Stat1 Jak2 Jak1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Ddc Tph1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Upp1 Upp2 Uprt Nme3 Nme2 Nme4 Uck1 Uck2 Uckl1 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Vamp8 Vamp1 Vamp3 Gria4 Vamp2 Gria3 Snap29 Gria2 Snap25 Grik5 Snap23 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Gng10 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb4 Gnb3 Gnb5 Prkar1b Prkx Prkacb Grm1 Grm5 Adcy10 Prkar2a Prkar2b Gnai2 Gnai3 Prkaca Cacna1a Cacna1b Gnb1 Gnai1 Cacna1e Grm4 Grm7 Grm6 Grm8 Vti1a Grin2a Slc17a7 Stx1b Cacnb1 Stx1a Slc1a1 Slc1a3 Slc1a2 Slc1a7 Grin1 Slc1a6 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Tnfrsf1b Madd Pik3cb Tnfrsf1a Pik3cd Tradd Casp9 Nfkb2 Nfkb1 Traf2 Cycs Bcl2l1 Xiap Endog Tnfsf10 Rela Map3k1 Ikbkb Apaf1 Tnfrsf10b Lta Fadd Atf7 Ltb Atf6 Atf4 Jdp2 Atf3 Aifm1 Map2k7 Gzmf Map4k3 Atf6b Cradd Bak1 Tp53 Eif2s1 Akt3 Casp8 Akt2 Casp7 Prkra Casp3 Bik Ripk1 Map4k2 Fos Diablo Bax Rel Fas Faslg Daxx Map3k14 Atf1 Chuk Map2k4 Mapk9 Jun Mapk8 Map2k3 Bcl2 Mapk1 Igf2r Mapk3 Akt1 Prkcq Prkcg Prkch Prkcb Prkcd Prkce Prkca Atf2 Eif2ak2 Nfkbia Birc3 Birc2 Mapk10 Tnf Bcl2l11 Pik3cg LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Pik3cb Pik3cd Map2k2 Map2k1 Hras Map3k1 Rhoc Rhoa Map2k7 Rhob Pdpk1 Kras Akt3 Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Tiam1 Ralgdsl1 Sos1 Rala Ralb Shc1 Exoc2 Pld1 Pld2 Ralgds Srf Elk1 Map2k6 Map3k4 Stat3 Mapk12 Mapkapk3 Stat1 Mapk13 Pak1 Mapk14 Mapkapk2 Pak3 Pak2 Map2k4 Mapk9 Jun Mapk8 Map2k3 Mapk11 Mapk1 Braf Ets1 Pik3c3 Mapk3 Rac2 Akt1 Rac1 Araf Gsk3a Nras Raf1 Atf2 Grb2 Mapk10 Pik3cg ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Elk1 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Map2k2 Itpr1 Map2k1 Mapk1 Mapk3 Gng11 Gnb1 Plcb3 Gng10 Prkca Raf1 Plcb2 Grk3 Plcb1 Grk2 Agtr1a Gng3 Arrb2 Arrb1 Egr1 Gnaq Agt Gng7 Gng8 Gngt2 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Taf6 Gtf2e1 Taf2 Gtf2a1l Polr2c Taf1c Taf9 Polr2h Polr2f Ttf1 Taf9b Taf11 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Brf2 Brf1 Tbpl1 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 Taf7 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Chek2 Gadd45b Gadd45a Hdac1 Sfn Cdkn2a Traf2 Mta2 Ccnb1 Gtse1 Cdk1 Sirt1 Cdkn1a Cdc25c Ccne1 Crebbp Pdpk1 Tp53 Akt3 Tp73 Mdm2 Akt2 Mdm4 Akt1 Pten Cdk2 Atm Tp63 Atr Gadd45g Sumo2 Sumo3 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Prkcz Vamp8 Vamp1 Vamp3 Vamp2 Snap29 Snap25 Snap23 Plcb4 Gna11 Plcb3 Gng10 Gna14 Plcd1 Plcd4 Plcb2 Plcb1 Gng3 Gng5 Plcl1 Gnaq Gng7 Gng8 Gngt2 Plcz1 Plce1 Gnb4 Gnb3 Gnb5 Gng12 Trh Trhr Stx3 Cga Cacnb3 Cacnb4 Cacnb2 Tshb Cacna1a Cacna1b Plcg1 Prkcq Plcg2 Gnb1 Prkcg Prkch Prkci Prkcb Cacna1e Prkcd Prkce Prkca Cacnb1 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b7 Hsd17b6 Hsd17b3 Soat2 Soat1 Hsd17b1 Hsd17b2 Lipa Cyp19a1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Wnt10a Wnt10b Acta1 Actb Actr2 Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Wnt6 Wnt7b Wnt3a Wnt7a Wnt2 Tcf7l1 Wnt1 Actg1 Wnt4 Actg2 Wnt3 Tcf7l2 Fzd1 Actc1 Actbl2 Fzd2 Fzd5 Fzd4 Fzd6 Fzd9 Fzd8 Wnt2b Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Cdh6 Pcdhgb7 Cdh5 Pcdh10 Pcdhgb2 Cdh2 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdhgc3 Pcdhb17 Pcdhb19 Cdh24 Cdh23 Cdh20 Celsr3 Celsr1 Pcdhb10 Celsr2 Pcdh20 Fer Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac2 Cdhr2 Pcdha13 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Cdh18 Cdh17 Pcdh11x Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Ptpn1 Ctnnb1 Pcdh8 Pcdh7 Pcdh9 Pcdhga5 Pcdhga7 Pcdhga8 Pcdhga1 Ctnnd2 Pcdhga2 Ctnnd1 Pcdhga3 UNTITLED%PANTHER PATHWAY%P06664 untitled Tgif1 Skil Rela PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc3 Aoc1 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle Mdh1 Ogdh Aco2 Sdhc Pdk2 Cs Fh Pdha2 Suclg1 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5f1b Atp5f1c ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation Odc1 Azin1 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Nt5e Dpysl5 Aldh6a1 Dpys Dpyd Dpysl2 Cda Dpysl3 Abat Upb1 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Gnb4 Prkaca Gnb3 Gnal Gnb5 Adrb1 Gng12 Gnb1 Prkx Prkacb Gng10 Adcy7 Prkar2a Gng3 Prkar2b Gng5 Gng7 Gng8 Gngt2 Adcy2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Tsc1 Mdm2 Igf1r Mdm4 Foxo3 Pten Gsk3a Foxo1 Gsk3b Irs1 Irs2 Ins2 Insr Igf2r Igf2 Igf1 Pdpk1 Tsc2 Insrr HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Gnb4 Prkaca Gnb3 Gnal Gnb5 Gng12 Hrh2 Gnb1 Prkx Prkacb Gng10 Adcy7 Prkar2a Gng3 Prkar2b Gng5 Gng7 Gng8 Gngt2 Adcy2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Gnb4 Gnb3 Gnal Gnb5 Gng12 Adrb3 Gnb1 Gng10 Adcy7 Gng3 Gng5 Gng7 Gng8 Gngt2 Adcy2 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Nt5e Ampd3 Gda Xdh METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Gnb4 Gnb3 Pomc Gnal Gnb5 Gng12 Gnb1 Crh Crhr2 Crhr1 Gna11 Gng10 Gna14 Gng3 Gng5 Gnaq Gng7 Gng8 Gngt2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Prkcz Mapk15 App Mapk12 Mapk13 Mapk14 Mapk9 Cacna1f Cacna1d Kat5 Mapk8 Klc1 Cacnb2 Adam17 Mapk4 Cacna1c Klc4 Klc3 Mapk11 Klc2 Apba1 Mapk1 Apba2 Bace2 Apba3 Mapk6 Pkn1 Bace1 Mapk3 Psenen Psen1 Prkcq Psen2 Prkcg Prkch Prkci Ncstn Prkcb Aph1b Prkcd Pkn2 Prkce Prkca Cacnb1 Mapk10 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo Slit3 Robo1 Ntn1 Rac2 Cxcr4 Ntn3 Abl1 Rac1 Srgap1 Dcc Ntng1 Rhoc Cxcl12 Slit1 Slit2 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis Dscaml1 Dhodh Cad Ctps2 Ctps1 Cps1 Nme3 Nme1 Nme2 Nme4 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Prkcz Pik3cb Pik3cd Pik3c2b Pik3c2a Erbb4 Map2k2 Map2k1 Hras Stat6 Stat4 Map2k7 Akt3 Akt2 Pik3r5 Rras Sos1 Shc1 Map2k6 Stat5a Map3k4 Stat5b Stat3 Mapk12 Stat2 Stat1 Mapk13 Mapk14 Shc3 Map2k4 Rasa2 Mapk9 Rasa1 Mapk8 Map2k3 Grap Mapk11 Prkd3 Mapk1 Prkd1 Braf Prkd2 Pik3c3 Mapk3 Gab1 Rac2 Gab2 Akt1 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Erbb2 Prkch Erbb3 Prkci Mras Nras Rasal2 Prkcb Egfr Phldb2 Map3k3 Prkcd Nf1 Map3k2 Rras2 Prkce Dab2ip Prkca Pebp4 Raf1 Spry2 Spry1 Spry4 Pebp1 Shc2 Mapk10 Pik3cg PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Plg Mmp9 Plau Serpine1 Serpinf2 Serpinb2 Fgb Fga Mmp13 Mmp1 Fgg Mmp3 Plat PNAT%PANTHER PATHWAY%P05912 PNAT Vamp8 Gnb4 Vamp1 Gnb3 Vamp3 Epb41l3 Vamp2 Drd1 Drd5 Snap29 Ppp1cc Gnaz Prkx Snap25 Prkacb Snap23 Stx3 Epb41l2 Clic6 Adcy7 Ppp1r1b Prkar2a Kcnk3 Prkar2b Epb41l1 Gnai2 Slc18a2 Adcy2 Drd2 Gng11 Ppp1ca Gnai3 Drd4 Prkaca Kcnk9 Epb41 Gnb1 Flna Gnai1 Slc6a3 Gng3 Gng8 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Fbxw11 Btrc Gli1 Crebbp Shh Smo Ptch1 Sufu Stk36 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Gnb4 Gnb3 Gnb5 Prkar1b Prkx Prkacb Adcy10 Kcnj9 Kcnj6 Kcnj5 Slc5a7 Chrm2 Gnao1 Chrm4 Gnat2 Prkar2a Gnat1 Prkar2b Gnai2 Gng11 Gnai3 Prkaca Gnb1 Gnai1 Kcnj3 Gng10 Gng3 Slc18a3 Gng5 Slc6a8 Gng7 Gng8 Gngt2 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Gfpt1 Gfpt2 Amdhd2 Gnpda2 Npl TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Hras Crebbp Bmp10 Bmp8a Bmp15 Dcp1b Lefty2 Acvr1 Foxh1 Smurf2 Smurf1 Jund Acvr1c Snip1 Skil Lefty1 Rras Tgfb2 Tgfb3 Gdnf Cited1 Acvrl1 Cited2 Acvr1b Amhr2 Fosl1 Mstn Gdf2 Bmpr1a Gdf3 Gdf6 Bmp7 Bmp6 Bmp5 Gdf7 Bmp4 Bmpr2 Smad1 Bmp3 Smad2 Gdf9 Nodal Map3k7 Bmp2 Smad3 Smad4 Bmp1 Mapk12 Smad9 Acvr2a Mapk13 Tll2 Mapk14 Gdf15 Inhba Inhbb Acvr2b Junb Inhbc Mapk9 Tgfbr1 Jun Smad5 Mapk8 Tgfbr2 Smad6 Inhbe Smad7 Gdf11 Mapk11 Gdf10 Mapk1 Mapk3 Nras Atf2 Mapk10 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation Plg Plau F2r Kng2l1 Klkb1 Gp5 Proc Gp9 Gp1bb F13b Gp1ba Procr F10 Vwf F12 Proz F2 Itga2b Tfpi Serpina10 F3 Thbd F7 F8 F9 Pros1 Fgb Fga Fgg Plat PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Pik3cb Gnb4 Casp9 Gnb3 Nos3 Gnb5 Rps6kb1 Foxo1 Irs1 Gnat2 Insr Gnai2 Pdpk1 Akt3 Akt2 Gnai3 Akt1 Foxo3 Gnb1 Pik3r5 Gsk3b Gnai1 Nras Ptger1 Sos1 Gna11 Foxo4 Gngt1 Ywhaz Gna14 Pik3r1 Pik3r2 Pik3r3 Gnaq Gngt2 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Drd1 Drd5 Kcnj9 Kcnj6 Kcnj5 Chrm2 Chrm4 Rap1a Rap1b Gsk3b Adcy2 Drd2 Drd4 Prkaca Gsk3a Gnb1 Gnai1 Gngt1 Adora2b Adora2a Adra2c Adra2b Htr6 Htr7 Oprl1 Grm2 Phka1 Phka2 Adrb2 Adra1b Adra1a Adra1d Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Oprm1 Htr5a Phkb Chrm1 Chrm3 Chrm5 Hrh4 Hrh3 Adora1 Gnrhr Gys1 Gys2 Clta Cltb Cltc Mtnr1a Creb1 Creb3 Phkg1 Phkg2 Crebbp Mtnr1b Pygb Pygl Pygm Gpr50 Oprk1 Creb3l3 Creb3l4 Creb3l1 Creb3l2 Gng10 Hrh1 Creb5 Gng3 Gng5 Gng7 Gng8 Gngt2 Oprd1 Adrb1 Gng12 Hrh2 Adrb3 Prkar1b Prkacb Grm1 Grm5 Adcy3 Adcy7 Prkar2a Htr2a Prkar2b Htr2c Htr1d Htr2b Htr1f Gnai2 Htr1b Htr1a Gnai3 Htr4 Gnal Adcy4 Adcy1 Adcy8 Adcy5 Adcy6 Kcnj3 Grm4 Grm7 Grm6 Grm8 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Prkcz Pik3cb Pik3cd Pik3c2b Pik3c2a Map2k2 Map2k1 Hras Map2k7 Map3k6 Akt3 Frs2 Akt2 Frs3 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Sos1 Shc1 Map2k6 Map3k4 Mapk12 Mapk13 Mapk14 Shc3 Map2k4 Rasa2 Mapk9 Rasa1 Mapk8 Map2k3 Grap Mapk11 Mapk1 Pik3c3 Mapk3 Rac2 Akt1 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Map3k3 Prkcd Map3k2 Prkce Prkca Raf1 Spry2 Ptpn6 Spry1 Spry4 Pebp1 Mapk10 Pik3cg ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Cad Asl Nags Ass1 Cps1 Otc HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Gnb4 Gnb5 Gng12 Gnat1 Gnb1 Cnga3 Pdc Cnga1 Grk1 Rho Calml3 Rgs9 Gngt1 Cngb1 Gng10 Pde6a Pde6b Cngb3 Rcvrn Gng13 Gng3 Gng5 Gng7 Gng8 Gngt2 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Ywhag Ywhae Mapk15 Elk1 Th Ywhab Sfn Psmb10 Sncaip Psmb7 Mapk12 Prkn Psmb1 Gpr37l1 Mapk14 Septin5 Psmb3 Stx7 Septin2 Septin1 Gpr37 Mapk9 Stx12 Ndufv2 Mapk8 Psma7 Snca Ccne1 Mapk1 Mapk3 Ywhaz Pld2 Slc6a3 Psma4 Psma3 Psma6 Psma5 Ccne2 Psma2 Psma1 Mapk10 Cask Ywhah MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Prkcz Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Chrm1 Itpr1 Chrm3 Grin2d Grin2c Slc5a7 Grin2b Pkn1 Gng11 Prkcq Gnb1 Prkcg Prkch Prkci Prkcb Plcb4 Gna11 Prkcd Pkn2 Gng10 Gna14 Prkce Prkca Grin2a Gng3 Slc18a3 Gng5 Gnaq Gng7 Gng8 Grin1 Gngt2 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Gnai3 Gnb4 Oprd1 Gnb3 Gnb5 Gng12 Gnb1 Gnai1 Gng10 Pdyn Penk Adcy7 Gng3 Gng5 Gng7 Gnai2 Gng8 Gngt2 Adcy2 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Top2a Top1 Dna2 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rfc2 H3f3a Rpa2 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Mcee Pccb DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Dscaml1 Adsl Rrm2 Impdh2 Rrm2b Ak3 Gmps Nme3 Ak2 Nme1 Nme2 Ak4 Nme4 Adss2 Atic Nme7 Ppat Nme6 Guk1 Gart VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway Rxra Vdr Rara Gc F13b HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Sstr5 Prkcz Sstr4 Sstr3 Sstr2 Sstr1 Oprm1 Drd1 Chrm1 Drd5 Chrm3 Chrm5 Adora1 Gnrhr Clta Cltb Cltc Chrm2 Chrm4 Rhoa Oprk1 Rap1a Rap1b Plcb4 Gna11 Plcb3 Gng10 Gna14 Plcb2 Gng13 Plcb1 Dnajc27 Gng3 Gng5 Gnaq Gng7 Gng8 Gngt2 Gnb4 Oprd1 Gnb3 Itpr3 Gng12 Itpr2 Itpr1 Grm1 Grm5 Gnao1 Drd2 Drd4 Cacna1a Cacna1b Prkcq Gnb1 Prkcg Prkch Prkci Prkcb Cacna1e Grm4 Prkcd Gngt1 Grm7 Adora2b Grm6 Prkce Adora2a Grm8 Prkca Rap1gap Rasgrp3 Grm2 Oprl1 Rasgrp4 Rasgrp1 Rasgrp2 Arhgef1 Bdkrb2 Bdkrb1 Gpr45 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Grb14 Prkcz Fgf1 Pik3cb Dok1 Pik3cd Dok2 Casp9 Dok3 Nos3 Axin1 Pik3c2b Grb7 Pik3c2a Pdgfc Ptk2 Tcf7 Map2k2 Efnb1 Tgfb1i1 Efnb2 Map2k1 Jag2 Hras Jag1 Map3k1 Pla2g4d Angpt1 Apc2 Wnt5a Epha3 Ephb1 Dll1 Ephb2 Ephb3 Wnt5b Dll3 Rhoc Dll4 Dlk1 Rhoa Apc Wnt10a Tek Rhob Wnt10b Akt3 Notch4 Akt2 Notch1 Notch2 Fos Gsk3b Crk Sos1 Shc1 Pld1 Pld2 Src Rbpjl Wnt7b Dvl1 Dvl3 Wnt7a Wnt2 Wnt1 Tcf7l2 Fzd1 Stat3 Stat1 Fzd2 Fzd5 Rasa1 Pdgfrb Wnt2b Pdgfra Pdgfa Pdgfb Grap F2r Nck2 Jak1 Nck1 Ctnnb1 Frs2 Frs3 Fgfr1 Hspb1 Mapkapk3 Pak1 Mapk14 Mapkapk2 Pak3 Pak2 Map2k4 Jun Mapk8 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Crkl Pik3c3 Mapk3 Cryab Akt1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Dscaml1 Rrm2 Tyms Rrm2b Dtymk Nme3 Nme1 Nme2 Nme4 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Syt12 Syt7 Syt6 Vamp1 Unc13c Rab3a Stxbp1 Unc13b Syt15 Stx2 Unc13d Snap25 Stx1b Stx1a Syt5 Syt3 Syt2 Syt1 Syt11 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Pik3cb Plau Ptk2 Bcl2l1 Map2k2 Map2k1 Irs1 Cdh1 Itgav Rhoa Elk4 Pdpk1 Foxo3 Casp3 Fos Itgb1 Bax Rps6ka3 Nr2c2 Gsk3b Clu Ier3 Rps6ka1 Rps6 Map3k14 Sp1 Crk Sp3 Sos1 Elavl1 Shc1 Akt1s1 Yes1 Snai1 Tcf4 Src Hbegf Nos1 Bcar1 Hdac7 Akap1 Cckbr Arrb2 Pparg Egr1 Gucy2e Arhgef28 Cd38 Ptgs2 Camk4 Map2k5 Ptpn11 Ptk2b Tpcn1 Bad Cck Gast Stat3 Map3k11 Jak2 Slc18a2 Prkaca Gnb1 Lyn Ppp3ca Nfkbia Grb2 Mapk10 Eif4ebp1 Rps6kb1 Creb1 Ctnnb1 Nfatc2 Odc1 Traf6 Srf Mef2d Elk1 Ywhab Map2k6 Hspb1 Foxo1 Itpr1 Pak1 Mapk14 Prkacb Eif4e Map2k4 Mapk9 Mef2c Jun Mapk8 Bcl2 Mapk1 Rock1 Pla2g4a Prkd1 Braf Prkd2 Mapk3 Akt1 Rac1 Plcg1 Araf Prkcq Adcy1 Prkch Prkcb Prkcd Prkce Prkca Raf1 Pik3r1 Atf2 Pxn Mmp3 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Pklr Eno1 Bpgm Eno2 Pfkl Pkm Pgam2 Pgk1 Gpi Tpi1l2 Pfkm Hk2 Aldoa NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Notch4 Notch1 Notch2 Notch3 Jag2 Jag1 Ncor2 Cirsr Maml1 Numb Dll3 Dll4 Dlk1 Rbpjl GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Csad Gad1 Aldh5a1 Gad2 Abat FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Casp9 Map2k4 Apaf1 Mapk9 Jun Fadd Mapk8 Faf1 Parp3 Parp2 Parp1 Cflar Lmnb1 Lmnb2 Casp8 Gsn Casp7 Casp6 Capg Casp3 Lmna Scin Dffb Fas Faslg Daxx Mapk10 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Prkcz Pik3cb Pik3cd Arpc3 Nfkb2 Arpc2 Arpc5 Rela Ikbkb Col12a1 Cxcr1 Cxcr2 Rhoc Rhoa Acta1 Actb Pdpk1 Itgal Akt3 Akt2 Itgb7 Jund Itgb1 Rras Sos1 Shc1 Il2 Actg1 Col6a2 Ptk2b Actg2 Stat3 Actc1 Actbl2 Chuk Junb Grap Jak2 Adcy2 Vwf Prkaca Cxcr3 Cxcr5 Cxcl10 Fpr1 Fpr3 Ccr10 Ccr1 Gnai1 Xcr1 Ccrl2 Ltb4r2 Vav1 Rhog Ccr9 Ccr8 Ccr7 Ccr6 Ccr5 Myo3b Ccr4 Ccr3 Ccr2 Cx3cr1 Ifnar1 Camk2d Ccl11 Myh2 Ccl12 Myh3 Ccl7 Myh8 Camk2a Myh9 Ccl5 Myh4 Ccl4 Myh6 Ccl3 Myh7 Ccl2 Pf4 Prex1 Cx3cl1 Nfat5 Ccl22 Ccl20 Ccl21 Myh11 Myh10 Myh7b Kras Nfatc4 Nfatc3 Nfatc2 Plcb4 Gna11 Plcb3 Gng10 Gna14 Plcd1 Plcd4 Plcb2 Plcb1 Gng3 Gng5 Plcl1 Gnaq Gng7 Cask Gng8 Plcz1 Plce1 Gnb3 Mylk2 Itpr3 Mylk3 Gng12 Itpr2 Itpr1 Prkx Pak1 Prkacb Pak6 Pak3 Pak2 Pak5 Pak4 Jun Mylk Arpc4 Gnao1 Mapk1 Rock1 Col14a1 Gnai2 Mapk3 Gnai3 Cxcr4 Ifng Rac2 Akt1 Rac1 Plcg1 Araf Arpc1b Plcg2 Arpc1a Adcy5 Nras Adcy6 Prkcb Prkce Raf1 Pik3cg XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Pnp Gda Prtfdc1 Hprt1 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Grik5 Arpc5 Hip1 Apaf1 Grik2 Bdnf Grik1 Ift57 Grik4 Dync1h1 Grik3 Dnal4 Cltb Grin2d Dctn1 Grin2c Rhoj Rhoq Grin2b Dync1i2 Dync1i1 Ap2a2 Ap2a1 Map2k7 Crebbp Hap1 Hip1r Kalrn Acta1 Htt Actb Gapdhs Tp53 Actr2 Dync1li2 Dync1li1 Tp73 Casp8 Dync2h1 Dnai2 Dynll1 Casp3 Dynll2 Capn9 Cyc1 Fos Capn5 Capn7 Capn6 Capn1 Capn3 Tp63 Capn2 Dlg4 Sp1 Dnah5 Dnah8 Cyfip1 Capns1 Capns2 Capn11 Tbp Capn12 Tubb2b Actg1 Tubb2a Actg2 Actc1 Actbl2 Map2k4 Mapk9 Jun Tubb5 Tubb6 Tubb3 Map3k10 Tubb4b Rac2 Rac1 Arpc1b Arpc1a Rhog Grin2a Grin1 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Acly Pc Pklr Me1 Clybl Pck1 Cs Pkm Pdha2 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Pik3cb Pik3cd Map2k2 Map2k1 Hras Map3k1 Ikbkb Akt3 Akt2 Fos Sos1 Zap70 Cd28 Cd86 Cd80 Lck Lcp2 Cd3g Cd247 Cd3e Cd3d Ppp3cc Lat Itpr1 Chuk Pak1 Pak3 Pak2 Mapk9 Jun Mapk8 Mapk1 Nck2 Braf Nck1 Pik3c3 Mapk3 Akt1 Rac1 Plcg1 Araf Prkcq Vav3 Nras Grap2 Vav1 Vav2 Raf1 Pik3r1 Pik3r2 Pik3r3 Ptprc Ppp3ca Ppp3cb Nfkbia Pik3cg TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Elk1 Map3k7 Map3k8 Ikbke Map2k2 Tbk1 Chuk Ticam2 Mapk14 Map2k1 Irak4 Ecsit Nfkbie Ikbkb Tollip Irak1 Mapk9 Tlr10 Jun Myd88 Mapk8 Tank Irf3 Tlr7 Map2k3 Tlr6 Tirap Tlr4 Tlr3 Tlr2 Mapk3 Nfkbia Traf6 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Psat1 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Axin1 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Wnt10a Wnt10b Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Lrp6 Lrp5 Wnt6 Wnt7b Wnt3a Arrb2 Dvl1 Arrb1 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Hdac1 Wnt3 Tcf7l2 Fzd1 Fzd2 Fzd5 Fzd4 Fzd6 Fzd9 Fzd8 Wnt2b Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Cdh6 Pcdhgb7 Cdh5 Pcdh10 Pcdhgb2 Cdh2 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdhgc3 Pcdhb17 Ppp3ca Pcdhb19 Ppp3cb Cdh24 Cdh23 Cdh20 Celsr3 Celsr1 Pcdhb10 Celsr2 Pcdh20 Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac2 Cdhr2 Pcdha13 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Cdh18 Cdh17 Pcdh11x Cdh16 Cdh15 Cdh13 Crebbp Cdh12 Cdh11 Cdh10 Pcdh8 Pcdh7 Pcdh9 Pcdhga5 Pcdhga7 Pcdhga8 Pcdhga1 Pcdhga2 Pcdhga3 Ppp3cc Arr3 Smarce1 Srcap Tbl1x Nlk Kremen2 Kremen1 Siah2 Ino80 Csnk2a2 Ep400 Hells Hltf Csnk1a1 Prkcq Ppp2r5d Smarcal1 Prkcg Ppp2r5c Prkch Ppp2r5b Prkci Ppp2r5a Ankrd6 Prkcb Ppp2r5e Chd1l Arid1a Prkcd Pygo2 Pygo1 Prkce Tle4 Prkca Tle3 Tle2 Tle1 Ctnna2 Ctnna1 Csnk1g3 Hdac3 Csnk1g2 Hdac2 Tbl1xr1 Smarcb1 Hdac8 Prkcz Csnk2b Smarca2 Sag Smarca1 Smarca4 Csnk1d Csnk1e Smarca5 Ctnnal1 Ppp3r2 Ppp3r1 Dact1 Smarcd1 Smarcd3 Smarcd2 Smarcc2 Fbxw11 Smarcc1 Btrc Gsk3b Smad1 Smad4 Smad5 Gnb1 Ctnnb1 Ppp2cb Ppp2ca Nfatc4 Nfatc3 Nfatc2 Siah1 Plcb4 Gna11 Plcb3 Gng10 Gna14 Gng13 Plcb2 Plcb1 Gng3 Gng5 Gnaq Gng7 Gng8 Gnb4 Gnb3 Itpr3 Gng12 Itpr2 Itpr1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Aprt Ada Pnp Prtfdc1 Xdh Hprt1 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipc Lipe METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Vamp8 Gnb4 Vamp1 Gnb3 Vamp3 Gnb5 Vamp2 Snap29 Prkar1b Prkx Snap25 Prkacb Snap23 Adcy10 Gnao1 Gnat2 Prkar2a Prkar2b Gnai2 Gng11 Gnai3 Prkaca Cacna1a Cacna1b Gnb1 Gnai1 Cacna1e Gng10 Stx1b Cacnb1 Grm2 Gng3 Stx1a Gng5 Gng7 Gng8 Gngt2 UNTITLED%PANTHER PATHWAY%P05916 untitled Gnai3 Gnb4 Gnb3 Gnb5 Gng12 Gnb1 Avp Oxt Gnai1 Gng10 Pdyn Gnao1 Adcy7 Gng3 Gng5 Gng7 Gnai2 Gng8 Oprk1 Gngt2 Adcy2 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Dpysl5 Rac2 Dpys Rac1 Pak1 Nrp1 Dpysl4 Plxnb1 Rhoa Sema3a Sema4d Cdk5 Fes Fyn Dpysl2 Arhgef1 Crmp1 Frk ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Gng11 Gnai3 Gnb4 Gnb3 Cacna1a Cacna1b Gnb1 Gnai1 Grm1 Grm5 Plcb3 Cacna1g Plcb2 Gnao1 Plcb1 Gng3 Gng5 Gng7 Cnr1 Gng8 Gngt2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Taf1a Polr1b Taf1c Taf1b Cavin1 Ubtf Ttf1 Psmc3ip Tbp Tbpl2 Tbpl1 Taf8 Rrn3 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Cda BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Gnb4 Prkaca Gnb3 Gnal Gnb5 Gng12 Gnb1 Prkx Prkacb Gng10 Adcy7 Prkar2a Gng3 Prkar2b Gng5 Adrb2 Gng7 Gng8 Gngt2 Adcy2 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Gnb4 Oprd1 Gnb3 Gnb5 Oprm1 Gng12 Prkx Prkacb Pdyn Creb1 Penk Gnao1 Adcy7 Prkar2a Prkar2b Gnai2 Adcy2 Gnai3 Prkaca Gnal Gnb1 Gnai1 Gng10 Gng3 Gng5 Gng7 Gng8 Gngt2 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Plce1 Itpr1 Prkcg Plcb4 Gna11 Plcb3 Prkcd Prkce Prkca Adra2c Adra2b Plcb2 Plcb1 Adra1b Adra1a LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Ace Ren Agt ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Idh3g Egln3 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc25a10 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway Nr3c1 Hsp90aa1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt Slc2a1 Nme2 Lalba CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Ikbkb Cd40 Mapk14 Traf3 Traf6 Elp1 Ikbkg Nfkbia Map3k1 Cd40lg Dusp1 Nfkb1 Chuk INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Pik3r4 Plcb4 Itpka Miox Ptpmt1 Inpp4a Pikfyve Ipmk Impa1 Mtor Isyna1 Vac14 Becn1 Sacm1l Inpp1 Pik3cb TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Prps1 Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Ace Ren Agt STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Amy1 Ugp2 Ugdh Pgm1 Gpi Gusb Pgm2l1 Gys1 Gaa Agl Pygl LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Aldh1a1 Gstm2 Cyp2c11 Aldh3a1 Cyp2a3 Cyp2b2 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Glud1 L2hgdh D2hgdh GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Gusb Ugt8 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Ptpn7 Cd3g Cd247 Elk1 Map2k7 Cd3d Calm2 Mapk3 Ubc Fyn Rac1 Ppp3ca Nfkbia Jun Map3k1 Ppp3cb Syk Nfkb1 Fos Rela Nfat5 Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Prkcb Plcg1 Prkca Mapk8 Shc1 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Abcc1 Ndufs3 Ndufs2 Ndufs7 Akr1a1 Xdh Cbr3 Akr1c3 Cbr1 Nqo1 Nos3 Abcb1a Abcg2 Ralbp1 Por CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Amt Cps1 Dld Gls2 Glud1 Hal Sds Aqp8 Asns Asrgl1 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Cacna1c Mapk3 Nfkbia Nfkb1 Rela Map2k1 Itpr1 Cacna1f Plcb1 Prkcb Cacna1d Mapk1 Raf1 Prkca Hras CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Abcc8 Cacna1a Ins2 Slc2a2 Cacna2d2 Cacnb1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Itpr1 Plcb1 Prkca PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Pik3r4 Inpp5d Erbb2 Synj1 Inpp4b Pik3c2a Pten Pik3c3 Egfr Fig4 Cdipt Ambra1 Plcb1 Pik3cd Pip4k2a Pikfyve Pik3r1 Vac14 Becn1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Mat2a Amd1 Srm Odc1 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Ace Ren Agt MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Glo1 Ldhd Hagh FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Gmppa Pmm1 Mpi Sord Uxs1 Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Cmpk1 Tyms Rrm2b Slc28a3 Rrm2 Slc29a1 Ctps1 Slc28a1 Dck Nme1 Dctd PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Nqo1 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Pdia2 Snta1 Sdf2l1 Kcnj5 Ugt1a6a Kcnj4 Kcnh2 Hyou1 Pdia6 Chrm2 Pdia4 Kcnk1 Kcnq1 Dnajb11 Slc8a1 Cyp1a2 Adrb1 Ugt1a9 Erp29 Atp1b1 Ugt1a5 Cacnb1 Atp1b3 Ugt1a1 Comt Atp1b2 Hspa5 Kcna5 Ephx1 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Cyp2e1 Kcnj11 Abcc9 Cacna2d2 Cyp2c11 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt Slc2a1 Nme2 Lalba PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Hsd17b10 Acat1 Hadh Echs1 Acadl Acss3 Acads Acaa2 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Sult1a1 Fmo1 Cyp2d4 Cyp3a73 Fmo3 Esr1 Ugt1a9 Ugt1a5 Cyp2b2 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Qars1 Rpl18a Rps18l1 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Abcc1 Abcc3 Cdkn1a Tp53 Abcc10 Abcb1a Ralbp1 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Cyp3a73 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Rdh16 Dhrs9 Bco1 Cyp3a9 Rpe65 Cyp3a18 Cyp26a1 Dgat1 Retsat Lrat Pdia2 Sdf2l1 Hyou1 Aldh1a1 Pdia6 Pdia4 Dnajb11 Cyp2a3 Erp29 Ugt1a1 Hspa5 Cyp2b2 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Abcd1 Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Ace Ren Agt DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Tyr Dct PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism Pah Tat Yars1 Farsa Hgd Hpd Got1 Farsb Fah NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Aldob Pfkm Rpia Gpi Fbp2 Taldo1 Rbks Rpe Tktl1 H6pd Prpsap1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Pfkm G6pc1 Gpi Eno1 Pgam2 Aldoa Hk2 Galm Tpi1l2 Pklr FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Gmppa Pmm1 Mpi Sord Uxs1 Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Ace Ren Agt INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Gng12 Gnb1 Ppp1ca Adcy2 Creb1 Gngt1 Fshr Prkacb Cga AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Ddc Th GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism Impa1 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Ptpmt1 Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Cyp2d4 Ugt1a9 Slc22a1 Cyp2b2 Ugt2b7 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Npr1 Cry1 Clock Csnk1e Per1 CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Elk1 Calm2 Mapk3 Rac1 Ppp3ca Jun Map3k1 Ppp3cb Syk Fos Nfat5 Map2k1 Lck Grb2 Cd79b Raf1 Lyn Orai1 Blnk Hras Prkcb Plcg1 Prkca Mapk8 Shc1 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Gnaq Gnb1 Plcb1 Chrm1 Htr2c Gngt1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Eprs1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Farsa Farsb Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Ace Ren Agt GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Pfkm G6pc1 Bpgm Gpi Eno1 Pgam2 Slc2a2 Aldoa Hk2 Galm Pklr Pgk1 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Cyp2e1 Sult1a1 Cyp2d4 Abcb1a Abcg2 Sult2a1 Abcc4 Abcc1 Abcc5 Gstp1 Ugt2b35 Gstt1 Pdia2 Sdf2l1 Ugt1a6a Hyou1 Pdia6 Pdia4 Dnajb11 Cyp1a2 Ugt1a9 Cyp2a3 Erp29 Ugt1a1 Hspa5 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Dbt Dld Bckdhb Sds Bckdha Pccb METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Slc46a1 Mthfd1l Mtfmt Ggh Dhfr Mthfd1 Mthfd2 Mthfs Ftcd Mthfr CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cyp2d4 Cbr1 Alox12 Prxl2b Cyp2u1 Cyp2c11 Alox5 Lta4h Ugt1a9 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Aars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Abcc1 Abcc3 Cdkn1a Tp53 Abcc10 Abcb1a Ralbp1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Alox15b Ltc4s Tbxas1 Pla2g2a Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Mt-co1 Cycs Ndufa1 Mt-atp6 Uqcrc1 Atp5f1d Sdhd Atp5f1c Atp5pb Sdhc Sdhb Atp5mc2 Sdha Atp5f1b Atp5f1a Gpd2 Slc25a4 Slc37a4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Ggcx Vkorc1 Nqo1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn10a Cyp1a2 Scn1b 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Btd Hlcs Acacb CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Ace Ren Agt OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism Ugp2 G6pc1 B4galt1 Pgm1 Gale Glb1 Lct Gla Galt Gaa Akr1b1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Cyp2e1 Aldh3a1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Ip6k1 Inpp5j Itpka Inpp4a Ipmk Impa1 Isyna1 Inpp4b Itpk1 Ippk Bpnt1 Nudt3 BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism Hmgcl Oxct1 Acat1 Hadh Echs1 Acads CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Pmvk Acat1 Hmgcr Fdps Mvd Idi1 Hmgcs1 Fdft1 Lss Sqle BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Gpi Pkm Pfkp Tpi1l2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Prps1 Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Pld2 Plpp1 Pisd Pcyt1a Pla2g15 Lypla1 Chat Dgka Chka Agpat1 Gpd2 Cdipt Ptpmt1 Pgs1 Gpam Gpd1 Cds1 Crls1 Pla2g2d Ptdss1 Ptdss2 Phospho1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway Cfp C8a Cfb C3 Cfd C5 C6 C7 C9 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Slc6a4 Cyp2d4 Cyp3a73 Cyp2c11 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Gla Sptlc1 Acer2 Cerk Sptlc2 Degs2 Enpp1 Samd8 B4galt2 Sphk2 Ugcg Ugt8 Sdr16c5 HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Sod3 Sod2 Sod1 Tyrp1 Cat NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Abcc1 Bche Ces2h Ces1d Top1 Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Ugt1a9 Erp29 Ugt1a1 Abcb1a Hspa5 Abcg2 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway Fgb Fga Col1a1 F10 Serpinc1 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Ace Ren Agt WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Gapdhs Bpgm Sdhd Sdhc Sdhb Sdha Cs Mdh1 Idh3g Mpc1 Fh Idh1 Idh3a Tktl1 H6pd Aco1 Pfkm Rpia Gpi Taldo1 Pdhx Aldoc Bckdhb Gls Acly Ogdh Pgk2 Slc16a1 Ireb2 Gsr Eno1 Pkm Glud1 Slc2a13 Cad PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Abcc1 Abcc3 Cdkn1a Tp53 Abcc10 Abcb1a Ralbp1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Mapk3 Socs1 Irs1 Insr Map2k1 Ptpn6 Ghr Grb2 Plcg1 Mapk1 Stat5a Stat5b Raf1 Ins2 Rps6ka1 Prkca Slc2a4 Sos1 Hras Jak2 Shc1 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Scnn1a Ren Scnn1b Scnn1g Ca1 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc14a2 Atp1b1 Atp1b3 Aqp3 Atp1b2 Aqp2 Atp6v1b1 Slc4a1 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd1 Gpd2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3r4 Pik3cd Ptpmt1 Prex1 Vac14 Inpp5f Plce1 Inppl1 Pik3c3 Zfyve16 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Jun Map3k1 Faf1 Arhgdib Map3k7 Pak1 Ripk2 Prkdc Parp1 Cflar Pak2 Lmnb1 Ptpn13 Lmnb2 Casp8 Rb1 Casp7 Casp3 Casp6 Sptan1 Lmna Map2k4 Fas Fadd Faslg Daxx Dffa Dffb Mapk8 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Abcc1 Slco1b2 Abcb1a Abcg2 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Agxt Pc Mpc1 Gpt Aars2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Rpia Tpi1l2 Rpe G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Prkca Erbb4 Erbb3 Psen1 Nrg2 Adam17 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Ace Ren Agt FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway Fgb Fga Col1a1 F10 Serpinc1 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Slc22a6 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Ugt2b1 Ugt1a2 Pdia2 Sdf2l1 Slc22a8 Hyou1 Alox12 Pdia6 Prxl2b Pdia4 Cyp2u1 Cyp2c11 Dnajb11 Alox5 Lta4h Ugt1a9 Alox15 Erp29 Cyp4f18 Cyp4f17 Ugt1a1 Ptgds Hspa5 Cyp2j4 Cyp2b2 Ugt2b7 Cyp4f4 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Slc22a6 Slc1a1 Ca1 Slc3a1 Slc38a4 Slc3a2 Slc7a6 Slc7a7 Slc7a5 Slc7a8 Slc7a9 Slc6a20a Slc4a4 Slc9a1 Aqp1 Slc22a2 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Elk1 Mapk3 Jun Fos Map2k1 Ptpn6 Epo Grb2 Plcg1 Epor Stat5a Raf1 Sos1 Hras Jak2 Mapk8 Shc1 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Cyp2d4 Oprm1 Ugt2b7 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Aldob Prps1 Rpia Pgm1 Gpi G6pd Pfkl Tkt Fbp1 Rpe Pgls HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Srf Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Gad1 Aldh6a1 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd Aldh2 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Chrm3 Abcc8 Cacna2d2 Adcy10 Vamp2 Rab3a Rapgef4 Gnaq Glp1r Gnb1 Camkk1 Itpr3 Plcb1 Cacna1a Prkca Slc2a2 Cacnb1 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Gnb1 Ppp1ca Htr6 Creb1 Gngt1 Prkacb METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Grin1 Cyp3a9 Cyp2d4 Oprm1 Grin2a Cyp2b2 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Ahcy Cbs Mettl6 Mat2a Scly Cth Slc39a8 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Gnb1 Adcy2 Ptgdr Gngt1 Prkacb DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gpi Gbe1 Gys1 Ganab Pgm2 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Pah Tat Yars1 Farsa Hgd Hpd Got1 Farsb Fah FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Rock1 Gnb1 Lpar4 Itpr1 Plcb1 Srf Akt1 Adcy1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Tpk1 Ntpcr Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Pex13 Abcd1 Crot Acsl1 Pex11g Slc25a20 Abcd2 Cpt2 Pex14 Crat CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Sts Sult2b1 Srd5a1 Hsd17b3 Ugt2b17 Hsd17b1 Ugt2b34l1 Cyp19a1 Akr1d1 Cyp17a1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Ass1 Gad1 Abat Asl Adsl Nars1 Aspa Ddo Asns Dars1 Cad Asrgl1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Rela Map2k1 Itpr1 Prkcb Plcb1 Mapk1 Raf1 Prkca Mapk3 Hras Nfkbia Nfkb1 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Cyp2e1 Acss1 Aldh2 Ddc Acss2 Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct Aldh1b1 Cat GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Gh1 Mapk3 Irs1 Map2k1 Ptpn6 Ghr Grb2 Plcg1 Mapk1 Stat5a Stat5b Raf1 Ins2 Rps6ka1 Prkca Slc2a4 Hras Jak2 Shc1 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Agxt Pc Mpc1 Gpt Aars2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Ugp2 Ugdh Galk1 Pgm1 Uxs1 Gale Gck Galt PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Pik3cg Pik3r6 Plcb1 Vav1 Plcg1 Prkca Akt1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Npr1 Clock Nmnat1 Nampt Ppargc1a Rora Sirt1 Nqo1 Nmnat2 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Gnb1 Ppp1ca Htr7 Creb1 Gngt1 Prkacb PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway Nr3c1 Hsp90aa1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway Slc22a6 Ugt2b1 Ptgs1 Ptgs2 Ugt1a2 Pdia2 Sdf2l1 Slc22a8 Hyou1 Pdia6 Pdia4 Dnajb11 Cyp2c11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Ugt2b7 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Gpi Eno1 Pgam2 Aldoart2 Pkm Galm Pfkp Tpi1l2 Slc2a1 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d4 Cyp1a2 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Prkar1b Prkar2a Prkar2b Atp1b4 Uqcr11 Mcu Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Prkacb Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Slc9a1 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Cyp1a2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Fmo3 Chrna4 Ugt1a9 Cyp2a3 Ugt1a5 Chrnb2 Cyp2b2 Chrna3 Aox1 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Tmlhe Setd7 Bbox1 Aldh9a1 Shmt1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Plpp1 Lipc Lpl Plpp2 Aldh3a1 Gpam Agpat1 Gpd1 Akr1b1 Gpd2 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Txn1 Pde10a Adsl Rac1 Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Abcc4 Atad1 Atic Abcc5 Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Adk Tpmt Slc29a2 Slc28a3 Slc29a1 Aox1 Hprt1 Prps1l1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Ak2 Nme2 Nme1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Txn1 Pde10a Adsl Rac1 Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Abcc4 Atad1 Atic Abcc5 Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Adk Tpmt Slc29a2 Slc28a3 Slc29a1 Aox1 Hprt1 Prps1l1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Gclc Got1 Cth Gclm Mpst Ctns Cdo1 Cars1 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Elk1 Mapk3 Jun Map3k1 Fos Map2k1 Grb2 Raf1 Hras Map2k4 Stat6 Egfr Rasa1 Csnk2a1 Jak1 Egf Prkcb Stat3 Plcg1 Stat2 Srf Stat1 Prkca Sos1 Mapk8 Shc1 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Slc46a1 Mthfd1l Mtfmt Ggh Dhfr Mthfd1 Mthfd2 Mthfs Ftcd Mthfr FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Gmppa Pmm1 Mpi Sord Uxs1 Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cbs Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Alpl Aox1 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Ugp2 Ugdh Pgm1 Uxs1 Gale Galk2 Galt EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Ace Ren Agt PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Ces1d Tymp Tyms Cda Slc28a1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Enpp1 Acp1 Tyr ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Ugt2b35 Atp1a2 Ugt2b1 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Ugt1a2 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Dnajb11 Ugt1a9 Erp29 Atp1b1 Cacnb1 Grin2a Atp1b3 Ugt1a1 Kcnd2 Atp1b2 Hspa5 Scn1b Chrnb2 Ugt2b7 Pomc MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Hsd17b10 Acat1 Hadh Echs1 Acadl Acss3 Acads Acaa2 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Plpp1 Agpat1 Gnpat Cept1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Sult1a1 Sult2b1 Chst11 Suox Bpnt1 Papss2 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Ace Ren Agt CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Cyp2d4 Cyp2c11 Ugt1a9 Ptgs1 Ptgs2 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Ak2 Nme2 Nme1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Slc5a1 Atp1a2 Atp1a1 Slc2a2 Atp1b1 Atp1a4 Atp1a3 Gck Atp1b3 Fxyd2 Atp1b2 Treh PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Maob Maoa Slc6a4 Cyp3a9 Cyp2d4 Aox1 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Gpt2 Slc25a22 Gpt Slc38a4 Slc1a4 Slc2a2 Slc2a4 Glud1 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Cmpk1 Tyms Rrm2b Slc28a3 Rrm2 Slc29a1 Ctps1 Slc28a1 Dck Nme1 Dctd WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Aldob Sdhd Sdhc Sdhb Pklr Sdha Cs Mdh1 Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Slc2a2 Idh1 Idh3a Dlst Pdhb Pgk1 Idh3b Aco2 Aco1 Dlat Dld Rpia Gpi G6pd Pfkl Taldo1 Slc1a5 Tkt Hk2 Slc16a1 Eno1 Pgam2 Gls2 Pkm Glud1 Pgls ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Tktl2 Pdha2 Slc16a4 Slc1a2 Sdhb Sdha Cs Mdh1 Dhtkd1 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Aldoart2 Idh3a Pdhb Pgk1 Idh3b Aco2 Aco1 Dlat Dld Rpia Gpi G6pd Taldo1 Hk2 Eno1 Gls2 Pkm Glud1 Pfkp HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Sc5d Msmo1 Hsd17b7 Cyp51 Nsdhl Dhcr24 Dhcr7 Lbr Ebp ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Jak1 Stat3 Mapk1 Mtor IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway Bche Ces2h Ces1d Oprm1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Plcb4 Ptpmt1 Ipmk Impa1 Cct3 Isyna1 Synj1 Vac14 Bpnt2 Becn1 Pik3c3 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Bcl2l1 Elk1 Cycs Mapk3 Rac1 Vav3 Rala Casp9 Pld1 Rhoa Chuk Ralgds Smad3 Map2k1 Smad4 Apaf1 Foxo4 Raf1 Hras Ralbp1 Akt1 Bad PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Gnaq Gnb1 Cyp21a1 Cyp11a1 Cyp11b2 Agtr1a SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Ddc Th ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Abcb1a Abcg2 Egfr NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Gclc Got1 Cth Gclm Mpst Ctns Cdo1 Cars1 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway Ace LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Rock1 Gnb1 Itpr1 Plcb1 Srf Lpar5 Akt1 Adcy1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Aldh1a1 Cyp3a73 Cyp2c11 Aldh3a1 Cyp2a3 Cyp2b2 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) Glp1r Slc10a2 Gpbar1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Pik3cg Pik3r6 Irs1 Insr Map2k1 Grb2 Mapk1 Raf1 Ins2 Slc2a4 Sos1 Hras Irs2 Map2k2 Pdpk1 Foxo1 Mapk8 Akt1 Shc1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Lars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Ip6k1 Ipmk Impa1 Isyna1 Synj1 Bpnt2 Ppip5k1 Nudt3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid Mdh1 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Pex13 Abcd1 Crot Acsl1 Pex11g Slc25a20 Abcd2 Cpt2 Pex14 Crat ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Plcd4 Pik3r4 Impa1 Synj1 Vac14 Becn1 Pik3c3 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2ry12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Drd1 Adcy2 Prkacb LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Cyp3a9 Cyp3a73 Ephx1 Cyp2b2 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Ccnb1 Pcna Ccne1 Ccnd1 Gadd45b Cdk4 Cdk2 Bcl2 Cdk1 E2f1 Bax Apaf1 Cdkn1a Rb1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C3 Cfd C5 C1qb C6 C1qa C7 Serping1 C9 C1s C1r C8a Masp2 Cfb C2 C4a C1qc Mbl2 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psma2 Psmc3 Psma1 Ubd Psmd13 Psmb5 Psmb4 Psmb7 Ubc Psmb6 Psmb1 Psmb3 Psmd4 Psmb2 Uba1 Psma7 Psma4 Psmc6 Psmc5 Psma3 Psma6 Psma5 Psmc2 Psmc1 Psmc4 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Plpp1 Lipc Lpl Plpp2 Aldh3a1 Gpam Agpat1 Gpd1 Akr1b1 Gpd2 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Elk1 Map2k7 Calm2 Jun Map3k1 Gna11 Pld1 Src Fshb Lhb Map2k1 Gnrh1 Gnrhr Grb2 Mapk1 Hbegf Camk2a Raf1 Adcy5 Cdc42 Egr1 Hras Mmp14 Lrrc7 Mmp2 Actn4 Atf4 Erbb4 Cga Itpr1 Plcb1 Prkcb Prkca Mapk8 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism Xdh Cyp2e1 Cyp2c11 Cyp1a2 Cyp2a3 Nat1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Ugt2b7 Pomc HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Gmppb Aldob Pmm1 Phpt1 Mpi Fcsk Sord Fpgt Gfus Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Gpi Eno1 Aldoart2 Pkm Hk2 Pfkp BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Elk1 Vav1 Mapk3 Rac1 Ppp3ca Jun Map3k1 Ppp3cb Syk Fos Map2k1 Grb2 Cd79b Raf1 Lyn Orai1 Blnk Hras Nfatc4 Nfatc3 Nfatc2 Ppp3cc Btk Prkcb Plcg1 Prkca Sos1 Mapk8 Shc1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Rock1 Gnb1 Itpr1 Plcb1 Srf Lpar1 Akt1 Adcy1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Hmgcl Oxct1 Acat1 Bdh1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Ass1 Gad1 Abat Asl Adsl Nars1 Aspa Ddo Asns Dars1 Cad Asrgl1 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Cyp3a73 Top2a PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pisd Pcyt1a Chka Cept1 Pcyt2 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Pik3r4 Cct3 Itpk1 Plcd1 Itpka Ambra1 Miox Ptpmt1 Impa1 Isyna1 Vac14 Becn1 Sacm1l Inpp1 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Endog Dffa Top2a Casp7 Casp3 Cad Hmgb2 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Gnb1 Prkar1b Prkar2a Prkar2b Gngt1 Adcy10 Prkacb Prkaca GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Kars1 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Prps1 Rpia Pgm1 Gpi Tktl2 G6pd Taldo1 Aldoart2 Fbp1 Rbks Pfkp Rpe TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Gusb Ugt8 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C3 C5 C1qb C6 C1qa C7 C9 C1s C1r C8a C2 C4a C1qc GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis Aldob Pfkm G6pc1 Bpgm Gpi Eno1 Pgam2 Slc2a2 Pkm Galm Tpi1l2 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Pfkfb2 Sord Fbp1 Aldoa CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Abcc8 Cacna1a Ins2 Slc2a2 Cacna2d2 Cacnb1 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Gusb Ugt8 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism Bst1 Nudt12 Nnmt Nnt Nampt Nmrk1 Qprt Enpp1 Nadsyn1 Nmnat2 Pnp Aox1 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Pfkfb2 Gpi Sord ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Ptgs1 Ptgs2 Top2a Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Abcc3 Erp29 Ugt1a1 Abcb1a Hspa5 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Abcb1a Slc22a1 Bad SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Wars1 Tdo2 Kynu Cyp1a1 Acmsd Ido1 Aldh2 Ddc Haao Aadat Aanat Tph1 Asmt Kmo Inmt Wars2 Cat LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation Ikbkb Slc25a1 Myd88 Traf6 Cd14 Tirap Sdhd Ikbkg Tlr4 Sdhc Nfkbia Acly Sdhb Sdha Mdh1 Cs Nfkb1 Rela Chuk Acaca Me1 Pfkp HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis Gng12 Gnb1 Adcy2 Avpr2 Gngt1 Fshr Prkacb COAGULATION%SMPDB%SMP0000586 Coagulation Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Acss2 Cyp2e1 Acss1 Aldh1b1 Aldh2 Cat MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Plpp1 Lipc Lpl Plpp2 Aldh3a1 Gpam Agpat1 Gpd1 Akr1b1 Gpd2 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Gars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Ugp2 G6pc1 B4galt1 Pgm1 Gale Glb1 Lct Gla Galt Gaa Akr1b1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Sc5d Msmo1 Hsd17b7 Cyp51 Nsdhl Dhcr24 Dhcr7 Lbr Ebp TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Pah Tat Yars1 Farsa Hgd Hpd Got1 Farsb Fah VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Abcc1 Slco1b2 Abcb1a Abcg2 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Nmnat1 Nampt Tp53 Sirt1 Nqo1 Nmnat2 Aifm2 Cd38 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Sdhd Slc7a7 Sdhc Sdhb Sdha Cs Slc38a5 Dhtkd1 Idh3g Pc Suclg1 Me1 Mpc1 Suclg2 Fh Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Got2 Slc1a5 Slc1a4 Acly Slc16a1 Gls2 Glud1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Rpia Tpi1l2 Rpe KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Ren Clcnkb Atp1a2 Slc12a6 Atp1a1 Atp1b1 Atp1a4 Atp1a3 Slc12a1 Atp1b3 Fxyd2 Atp1b2 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Slc46a1 Mthfd1l Mtfmt Ggh Dhfr Mthfd1 Mthfd2 Mthfs Ftcd Mthfr GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway Atp4a Atp4b DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Eprs1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Ddc Th SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Mapk3 Crk Nfkbia Gngt1 Cxcl12 Nfkb1 Pxn Gnaq Pik3c2g Gnb1 Ptk2 Map2k1 Bcar1 Cxcr4 Plcg1 Mapk1 Gnai1 Ptk2b Raf1 Hras ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Ace Ren Agt Agtr1a DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Drd1 Grin1 Maob Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Cyp3a9 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Aox1 Maoa Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Aldob Pfkm Fbp2 Aldoc Tpi1l2 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Cyp1a2 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Agxt Pc Mpc1 Gpt Aars2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Traf2 Map2k4 Ikbkb Map2k7 Mapk14 Ikbkg Nfkbia Jun Map3k1 Nfkb1 Chuk Atf1 Casp2 Ripk1 Tank Tnf Map2k6 Map4k2 Map2k3 Mapk8 Tradd Cradd TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Abcd1 Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Pik3r6 Plcb1 Plcg1 Prkca Akt1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Cpt1a Acsl1 Hadh Slc25a20 Hadha Hadhb Echs1 Acadl Cpt2 Acaa2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Nudt4 Itpka Ip6k2 Inpp4a Ipmk Impa1 Isyna1 Inpp1 Ppip5k1 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Aldob G6pc1 Bpgm Gpi Pank3 Fbp1 Pgm1 Pc Mpc1 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Fmo3 Chrna3 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Aox1 Ugt1a9 Cyp2a3 Atp1b1 Ugt1a5 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Cyp2b2 Pomc HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Uroc1 Hdc Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Ftcd Hal Cndp1 Aldh2 Maoa Aoc1 Aldh3a1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Iars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Got2 Mdh2 Slc25a11 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Bhmt Mat2a Aldh7a1 Shmt1 Chdh Gnmt Slc44a1 Dmgdh Mtr Shmt2 Sardh PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C8a Masp2 C2 C4a Mbl2 C3 C5 C6 C7 C9 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Acaca CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Ces1d Tymp Tyms Cda Slc28a1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Gad1 Aldh6a1 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd Aldh2 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Cyp3a73 Top2a TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Pc Me1 Mpc1 Slc25a11 Acly Pdhb Mdh1 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway P2ry12 Cyp3a73 Cyp2c11 Cyp1a2 Abcb1a Cyp2b2 Pon1 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Abcc8 Cacna1a Ins2 Slc2a2 Cacna2d2 Cacnb1 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Adra1a Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Hsd17b10 Mecr Ppt1 Hadha Hadhb Echs1 Acaa2 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Gab2 Map2k7 Mapk14 Fyn Rac1 Vav3 Syk Map2k1 Grb2 Mapk1 Raf1 Lyn Pik3r1 Lat Hras Tnf Map2k6 Map2k2 Map2k3 Akt1 Map2k4 Inpp5d Btk Il13 Pla2g4a Fcer1a Il4 Plcg1 Il5 Kras Prkca Pdk1 Ms4a2 Sos1 Nras Csf2 Lcp2 Mapk8 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Aldob Pfkm Rpia Gpi Fbp2 Taldo1 Rbks Rpe Tktl1 H6pd Prpsap1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Glud1 L2hgdh PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Rpia Gpi G6pd Tktl2 Taldo1 Fbp1 Rbks Pgm1 Aldoart2 Pfkp Rpe Prps2 Pgls SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Plcb1 Ikbkb Mapk1 Prkca Mapk3 Ikbkg Creb1 Nos3 Nfkb1 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Btd Hlcs Acacb LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway Atp4a Atp4b NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Ass1 Gad1 Abat Asl Adsl Nars1 Aspa Ddo Asns Dars1 Cad Asrgl1 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Gad1 Ggt6 Cdo1 Csad Ado SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway Pde4d HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Txn1 Pde10a Adsl Rac1 Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Abcc4 Atad1 Atic Abcc5 Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Adk Tpmt Slc29a2 Slc28a3 Slc29a1 Aox1 Hprt1 Prps1l1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Prps1 Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2ry12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Chaf1a Btg2 Hoxb9 Btg1 Prmt1 Ccnd1 Ngf Fgf1 Tp53 Rb1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Abcc8 Cacna1a Ins2 Slc2a2 Cacna2d2 Cacnb1 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Gucy1a2 Trpv4 Prkg2 Gucy1a1 Trpc7 Trpc4 Adcy10 Kcnq4 Trpc3 Gucy1b1 Kcnq3 Kcnq2 Nos3 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp2d4 Cyp2c11 Cyp1a2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Abcc1 Cmpk1 Pcyt1a Dck Pcyt2 Nme1 Slc22a3 Chpt1 Sult1a1 Abcc3 Abcb1a Slc22a1 Abcg2 Pgk1 Slc22a2 Abcc4 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d4 Abcb1a GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Ugp2 Ugdh Galk1 Pgm1 Uxs1 Gale Gck Galt ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c11 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Ptgs1 Ptgs2 Top2a Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Abcc3 Erp29 Ugt1a1 Abcb1a Hspa5 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway Atp4a Atp4b SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Gusb Ugt8 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification As3mt Gsto1 Aqp9 Aqp7 Slc2a4 Slc2a1 Pnp TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Pah Tat Yars1 Farsa Hgd Hpd Got1 Farsb Fah HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Ip6k1 Itpka Impa1 Isyna1 Inpp4b Itpk1 Inpp1 Ppip5k1 Nudt3 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Sars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Rock1 Gnb1 Itpr1 Plcb1 Srf Lpar2 Akt1 Adcy1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway Nr1h4 Slc10a2 Fgf19 Fgfr3 Fgfr4 Fgfr1 Fgfr2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Aldob Gapdhs Bpgm Gpi G6pc3 Eno1 Pkm Galm Pfkp Tpi1l2 Pgk2 Slc2a13 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Snta1 Sntb1 Abcc8 Cacna1a Slc2a2 Cacna2d2 Cacnb1 Gcg Scn5a FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Gmppb Aldob Pmm1 Phpt1 Mpi Fcsk Sord Fpgt Gfus Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Pex13 Abcd1 Crot Acsl1 Pex11g Slc25a20 Abcd2 Cpt2 Pex14 Crat INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Mylk Gnb1 Adcy2 Gngt1 Ptgir Prkacb Myl3 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Ikbkb Mapk14 Myd88 Traf6 Cd14 Tirap Ikbkg Tlr4 Nfkbia Map3k1 Nfkb1 Rela Chuk Map3k7 Ecsit Tollip Map2k4 Irak1 Tlr7 Tab2 Tlr6 Tlr5 Tlr3 Tlr2 Mapk8 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Abcc1 Bche Ces2h Ces1d Top1 Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Ugt1a9 Erp29 Ugt1a1 Abcb1a Hspa5 Abcg2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Aldob Pfkm Rpia Gpi Fbp2 Taldo1 Rbks Rpe Tktl1 H6pd Prpsap1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Pank1 Enpp1 Vnn1 Ppcdc Coasy METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Ace Ren Agt 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Elk1 Ikbkb Map2k7 Nfkbia Jun Map3k1 Nfkb1 Chuk Pak1 Mapk1 Hras Map2k6 Map2k2 Pdpk1 Akt1 Creb1 Gngt1 Atf2 Arhgef7 Prkacb Adora2a Braf Map3k4 Gnb1 Nfkb2 Prkcz Rap1a Pard6a Rapgef3 Rapgef2 Rps6ka1 Mapk11 Mapk8 Bad ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor Gnaq Itpr1 Plcb1 Prkca HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Slc46a1 Mthfd1l Mtfmt Ggh Dhfr Mthfd1 Mthfd2 Mthfs Ftcd Mthfr SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Hsd17b10 Mecr Ppt1 Hadha Hadhb Echs1 Acaa2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Tars1 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Sdhd Sdhc Sdhb Pklr Sdha Cs Mdh1 Dhtkd1 Suclg1 Mpc1 Fh Idh1 Idh3a Dlst Pdhb Pgk1 Idh3b Aco2 Aco1 Dlat Dld Rpia Gpi G6pd Pfkl Taldo1 Tkt Hk2 Gls Slc16a1 Eno1 Pgam2 Pkm Glud1 Slc1a3 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Ugp2 Ugdh Galk1 Pgm1 Uxs1 Gale Gck Galt PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rps24 Rpl14 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Aars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rpl7 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rps6 Rplp2 Rpl24 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rps15 Rpl23 Rpl8 Rpl13a Rpl9 Rpl18a Rpl38l1 Rps18l1 Rps20 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Abcc1 Abcc3 Cdkn1a Tp53 Abcc10 Abcb1a Ralbp1 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Adra1a Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Ace Ren Agt BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Ipmk Prex1 Inppl1 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq5 Coq6 Coq7 Coq2 Coq3 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Uroc1 Hdc Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Ftcd Hal Cndp1 Aldh2 Maoa Aoc1 Aldh3a1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Pde4d Cyp3a73 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Hadh Slc25a20 Acadm Hadha Hadhb Echs1 Acaa2 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Sult1a1 Sult2b1 Chst11 Suox Bpnt1 Papss2 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Cyp11b3 Hsd11b1 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Dnajb11 Srd5a1 Hsd17b3 Erp29 Cyp19a1 Akr1c1 Ugt1a1 Akr1d1 Hspa5 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Aldh1a1 Gstm2 Cyp2c11 Aldh3a1 Cyp2a3 Cyp2b2 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Idh3g Egln3 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc25a10 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Flt1 Vegfa NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway Ugt2b35 Ugt2b1 Oprm1 Ugt1a2 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Ugt2b7 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Aldob Pfkm Rpia Gpi Fbp2 Taldo1 Rbks Rpe Tktl1 H6pd Prpsap1 KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Cyp1a2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Pisd Chka Cept1 Pcyt2 Ptdss1 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Yars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Aldob Gapdhs Bpgm Gpi G6pc3 Eno1 Pkm Galm Pfkp Tpi1l2 Pgk2 Slc2a13 LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Pik3r4 Plcd3 Itpk1 Ippk Pik3c3 Fig4 Itpka Ambra1 Miox Ptpmt1 Inpp4a Pikfyve Ipmk Impa1 Isyna1 Vac14 Becn1 Inpp1 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2u1 Cyp2d5 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Hsd17b10 Ugt1a2 Acadsb Ivd Cyp2c11 Hadha Cyp2a3 Hadhb Ehhadh Cyp2b2 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Dars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Slc5a1 Atp1a2 Atp1a1 Slc2a2 Atp1b1 Atp1a4 Atp1a3 Lct Atp1b3 Fxyd2 Atp1b2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Ace Ren Agt METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Snta1 Sntb1 Scn5a LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Aldh1a1 Cyp2d4 Cyp3a73 Cyp2c11 Ugt1a9 Abcc10 Cyp2b2 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Prkca Erbb4 Erbb3 Psen1 Nrg2 Adam17 Egfr RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Mylk Pcna Rps6kb1 Ccnd1 Rac1 Cap1 Vav3 Ccnd3 Map3k1 Wasf1 Cfl1 Pld1 Ppp1r12b Actb Cdk5 Pak1 Myl2 Limk1 Arfip2 Pdgfra Cdkn1a Ralbp1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cbs Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Pfkm G6pc1 Bpgm Gpi Eno1 Pgam2 Slc2a2 Aldoa Hk2 Galm Pklr Pgk1 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Gusb Ugt8 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Irak1 Ikbkb Fadd Myd88 Traf6 Ubc Ikbkg Tlr4 Nfkbia Map3k1 Nfkb1 Rela Chuk Map3k7 Camkk1 Tnfrsf1b Il1a Ripk1 Tnfrsf1a Il1r1 Tnf Map3k14 Tradd METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism Actb GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Cyp3a9 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Cyp2b2 Pomc BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect Aldob Sdhc Sdhb Cs Mdh1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Slc2a2 Idh1 Idh3a Dlst Pdhb Pgk1 Idh3b Aco2 Aco1 Dld Rpia Gpi G6pd Pfkl Slc1a5 Tkt Pdhx Ogdh Slc16a1 Eno1 Pgam2 Pkm Glud1 Pgls CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Sts Sult2b1 Srd5a1 Hsd17b3 Ugt2b17 Hsd17b1 Ugt2b34l1 Cyp19a1 Akr1d1 Cyp17a1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Bhmt Ahcy Mat2a Aldh7a1 Chdh Mtr BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Btd Hlcs Acacb FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Ace Ren Agt ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Cars1 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Agxt Pc Mpc1 Gpt Aars2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Ces2h Cyp3a73 Ces1d Ugt1a9 Slco1b2 Impdh1 Abcb1a Abcg2 Impdh2 Ugt2b7 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Cyp3a73 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Rdh16 Dhrs9 Bco1 Cyp3a9 Rpe65 Cyp3a18 Cyp26a1 Dgat1 Retsat Lrat Pdia2 Sdf2l1 Hyou1 Aldh1a1 Pdia6 Pdia4 Dnajb11 Cyp2a3 Erp29 Ugt1a1 Hspa5 Cyp2b2 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway P2ry12 Cyp3a73 Cyp2c11 Cyp1a2 Abcb1a Cyp2b2 Pon1 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Tpo Tg Cyba Cybb Nox4 Nox3 Duox2 Slc5a5 Duox1 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Aldob Phpt1 Mpi Fcsk Sord Fpgt Gfus Khk Pfkl Pfkfb1 Pmm2 Fbp1 Tgds Amigo3 Tpi1l2 Akr1b1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Elk1 Ikbkb Map2k7 Nfkbia Jun Map3k1 Nfkb1 Chuk Pak1 Mapk1 Adcy2 Hras Map2k6 Map2k2 Pdpk1 Akt1 Adora2b Creb1 Gngt1 Atf2 Arhgef7 Prkacb Braf Map3k4 Gnb1 Nfkb2 Prkcz Rap1a Pard6a Rapgef3 Rapgef2 Rps6ka1 Mapk11 Mapk8 Bad FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Pfkm G6pc1 Bpgm Gpi Eno1 Pgam2 Slc2a2 Aldoa Hk2 Galm Pklr Pgk1 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Sst Abcc8 Cacna1a Slc2a2 Cacna2d2 Cacnb1 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Pik3cg Pik3r6 Rps6kb1 Slc7a5 Tsc2 Eif4ebp1 Tsc1 Eif4e Irs1 Insr Ins2 Mtor Irs2 Akt1 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Hmgcl Oxct1 Acat1 Bdh1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling Hif1a Il1b Sirt3 Nlrp3 P4ha3 Tlr4 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Cyp3a73 Ugt1a9 Ugt2b7 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Oprk1 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Gnb1 Ppp1ca Htr4 Creb1 Gngt1 Prkacb ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Cyp1a1 Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Erp29 Hsd17b1 Ugt1a1 Comt Hspa5 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway Elk1 Map2k7 Mapk14 Cacna2d2 Jun Map3k1 Gna11 Pld1 Src Fshb Lhb Map2k1 Cacna1f Gnrh1 Cacna1d Gnrhr Grb2 Mapk1 Hbegf Camk2a Raf1 Egr1 Hras Mmp14 Mmp2 Map2k3 Actn4 Atf4 Adcy1 Cacna1c Cga Egfr Itpr1 Plcb1 Prkcb Map3k2 Prkca Sos1 Cacnb1 Mapk8 Prkaca TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway Tyms INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Pik3r4 Cct3 Itpk1 Ippk Bpnt1 Pik3c3 Plcd1 Inpp5j Itpka Ambra1 Miox Ptpmt1 Inpp4a Ipmk Impa1 Isyna1 Vac14 Becn1 Sacm1l VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Elk1 Ikbkb Mapk14 Myd88 Traf6 Cd14 Tirap Ikbkg Tlr4 Nfkbia Jun Map3k1 Nfkb1 Fos Rela Chuk Map3k7 Map2k6 Map2k3 Ecsit Tollip Map2k4 Irak1 Tlr7 Tab2 Tlr3 Tlr2 Eif2ak2 Ppara Mapk8 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Ptpmt1 Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Ptpn7 Cd3g Cd247 Pik3cg Elk1 Vav1 Cd3d Mapk3 Ubc Fyn Rac1 Ppp3ca Nfkbia Jun Map3k1 Ppp3cb Nfkb1 Fos Rela Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Map2k4 Nfatc4 Nfatc3 Nfatc2 Ppp3cc Prkcb Plcg1 Prkca Zap70 Sos1 Cd3e Mapk8 Shc1 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Abcc5 Ppat Xdh Adk Tpmt Slc29a2 Slc28a3 Slc29a1 Rac1 Impdh1 Aox1 Hprt1 Gmps Abcc4 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacna1c Cacna2d2 Cacnb1 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Grin1 Itpr1 Xdh Nos1 Prkca Grin2a Ppp3ca Dlg4 Prkacb Aldh2 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Tktl2 Slc16a4 Sdhd Sdhc Sdhb Sdha Cs Mdh1 Dhtkd1 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Aldoart2 Idh3a Dlst Pdhb Pgk1 Aco1 Dlat Dld Rpia Gpi G6pd Taldo1 Gls Eno1 Pgam2 Pkm Glud1 Pfkp Slc2a1 Pgls TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Alpl Aox1 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Pik3r4 Inpp5d Erbb2 Synj1 Inpp4b Pik3c2a Pten Pik3c3 Egfr Fig4 Cdipt Ambra1 Plcb1 Pik3cd Pip4k2a Pikfyve Pik3r1 Vac14 Becn1 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cyp3a73 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Cyp2c11 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Gclc Got1 Cth Gclm Mpst Ctns Cdo1 Cars1 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Nr1h4 Slc10a2 Gpbar1 Slco1a4 Abcc4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Pex13 Abcd1 Acsl1 Slc25a20 Phyh Abcd2 Cpt2 Pex14 Crat Aldh2 Hacl1 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway Fgb Fga Col1a1 F10 Serpinc1 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt Slc2a1 Nme2 Lalba ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway Tyms DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Cyp2c11 Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Cyp2b2 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Pfkm G6pc1 Gpi Eno1 Pgam2 Aldoa Hk2 Galm Tpi1l2 Pklr CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Gnb1 Gngt1 Mc2r Prkacb Pomc GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Gusb Ugt8 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Aldh1a1 Cyp3a73 Cyp2c11 Aldh3a1 Cyp2a3 Cyp2b2 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway Atp4a Atp4b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin1 Calm2 Nos1 Prkca Grin2a Ppp3ca Dlg4 Prkacb AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Hsp90aa1 Arnt Ahr EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Elk1 Map2k7 Mapk3 Erbb4 Jun Map3k1 Fos Rasa1 Csnk2a1 Map2k1 Egf Prkcb Stat3 Grb2 Plcg1 Stat5a Srf Raf1 Prkca Hras Jak2 Mapk8 Shc1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Lpar6 Rock1 Gnb1 Srf Akt1 Adcy1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Gmppb Aldob Pmm1 Phpt1 Mpi Fcsk Sord Fpgt Gfus Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Gusb Ugt8 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Pfkm G6pc1 Gpi Eno1 Pgam2 Aldoa Hk2 Galm Tpi1l2 Pklr PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp2d4 Cyp1a2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a9 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Aldob Pfkm Fbp2 Aldoc Tpi1l2 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Hars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Gnb1 Lhcgr Ppp1ca Lhb Adcy2 Creb1 Gngt1 Prkacb Cga LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Slc5a1 Atp1a2 Atp1a1 Slc2a2 Atp1b1 Atp1a4 Atp1a3 Lct Atp1b3 Fxyd2 Atp1b2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Plpp1 Lipc Lpl Plpp2 Aldh3a1 Gpam Agpat1 Gpd1 Akr1b1 Gpd2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Gpi Pkm Pfkp Tpi1l2 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Prps1 Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Lpin1 Dgat1 Gpam Agpat1 Gpd1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cbs Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway Atp4a Atp4b VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Gad1 Aldh6a1 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd Aldh2 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Dld Aldh8a1 Acmsd Dlst Dhtkd1 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Wars1 Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Ip6k1 Itpka Inpp4a Ipmk Impa1 Isyna1 Inpp4b Itpk1 Ippk Inpp1 Ppip5k1 Nudt3 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway Fgb Fga Col1a1 F10 Serpinc1 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Sts Sult2b1 Srd5a1 Hsd17b3 Ugt2b17 Hsd17b1 Ugt2b34l1 Cyp19a1 Akr1d1 Cyp17a1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Atp4a Ren Atp4b Trpv5 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc12a3 Clcnkb Slc8a1 Atp1b1 Atp1b3 Aqp3 Atp1b2 Aqp2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Gab2 Map2k7 Fyn Rac1 Syk Map2k1 Lck Grb2 Mapk1 Raf1 Lyn Pik3r1 Lat Blnk Hras Tnf Map2k2 Akt1 Inpp5d Il13 Fcer1a Il4 Plcg1 Kras Prkca Ms4a2 Nras Csf2 Mapk8 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Ikbkb Sucnr1 Mapk3 Ptgs1 Ikbkg Creb1 Nfkb1 Chuk Plcb1 Mapk1 Prkca Mapk11 Nos3 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Sult1a1 Fmo1 Cyp2d4 Cyp3a73 Fmo3 Esr1 Ugt1a9 Ugt1a5 Cyp2b2 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Arhgdib Apaf1 Cycs Parp1 Arhgap5 Casp1 Prf1 Arhgap32 Casp8 Jun Casp9 Casp3 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Aldob Pfkm Fbp2 Aldoc Tpi1l2 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Nars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Aldob Gapdhs Bpgm Gpi G6pc3 Eno1 Pkm Galm Pfkp Tpi1l2 Pgk2 Slc2a13 INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Gnb1 Ppp1ca Adcy2 Hrh2 Creb1 Gngt1 Prkacb DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Gnb1 Itpr1 Plcb1 Lpar3 Akt1 Adcy1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Dlat Dld Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Gls2 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260211%WP2132%RATTUS NORVEGICUS Serotonin and anxiety Grin2d Ppp3ca Nlgn1 Adra1a Arc Prkcb Plek Htr2a Crh Htr2c Fos Htr1a ID SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP397%RATTUS NORVEGICUS ID signaling pathway Lck Smad5 Igf1r Srebf1 Myf5 Atf3 Myog Ccna2 Flt1 Ccne1 Myod1 Elk1 Elk4 Id2 Cd40lg Id1 Kdr Id4 Id3 Hes1 Nfkb1 Tcf7l2 Rb1 Egf Psmd4 Igf1 Ngf Bmp6 Rela Pax2 Smad1 Rbl2 Bmp2 Rbl1 Smad4 Pax8 Tert HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260211%WP1296%RATTUS NORVEGICUS Homologous recombination Pold2 Rad51 Rad50 Pold1 Brca2 Rad52 Pold4 Pold3 Fsbp Nbn NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP517%RATTUS NORVEGICUS Notch signaling pathway Aph1a Ncstn Ncor2 Dtx2 Dtx3 Dtx4 Dll3 Dll4 Rbpjl Maml1 Ctbp1 Ctbp2 Dtx3l Hdac1 Mfng Dvl1 Dvl2 Numb Dvl3 Hes5 Jag2 Jag1 Kat2a Rfng Crebbp Notch4 Numbl Notch1 Notch2 Lfng Hes1 Notch3 Psen1 Psen2 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260211%WP1301%RATTUS NORVEGICUS Mitochondrial gene expression Tfb1m Tfb2m Camk4 Prkar1b Ppp3ca Mterf1 Ppargc1a Nrf1 Ppargc1b Gabpa Myef2 Esrra Gabpb2 Tfam Pprc1 Polrmt AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260211%WP1287%RATTUS NORVEGICUS Amino acid conjugation of benzoic acid Acss2 Glyat IRINOTECAN PATHWAY%WIKIPATHWAYS_20260211%WP124%RATTUS NORVEGICUS Irinotecan pathway Bche Abcc1 Abcc2 Ces1f Ces1e Ces1d Ces2c Abcg2 VEGFR 3 SIGNALING%WIKIPATHWAYS_20260211%WP1964%RATTUS NORVEGICUS VEGFR 3 signaling Casp9 Bad Nos3 Shc1 Itpkc Flt4 Mapk1 Plcg1 Mapk3 Akt1 Pik3cg Grb2 Vegfd Vegfc ATM SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP654%RATTUS NORVEGICUS ATM signaling pathway Cdk6 Brca1 Pmaip1 Bax Ccne1 E2f1 Cdk1 Bak1 Cdkn1a Tp53 Rprm Casp9 Rb1 Sfnl1 Ccnb1 Casp3 Ccnd1 Cycs Chek2 Gadd45a Necab3 ESTROGEN SIGNALING%WIKIPATHWAYS_20260211%WP1279%RATTUS NORVEGICUS Estrogen signaling Taf9 Polr2g Polr2h Polr2f Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2h4 Gtf2h3 Gngt1 Jun Mapk14 Ercc2 Ercc3 Gper1 Esr1 Cdk7 Map2k1 Gnb1 Taf7 Taf6 Chuk Taf5 Hras Hdac1 Crebbp Mapk1 Akt1 Grb2 Ccnd1 Fos Brca1 Elk1 Mapk9 Ikbkb Ilk Braf Mnat1 Hdac3 Nfkb1 Hdac2 Hdac5 Taf13 Taf12 Gtf2f2 Tbp Ccnh Prkaca Gtf2b Gtf2e1 Sos1 Shc2 Polr2c Src Polr2a Polr2b WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260211%WP1288%RATTUS NORVEGICUS Wnt signaling pathway and pluripotency Jun Ctnnb1 Pafah1b1 Ctbp1 Map3k7 Ctbp2 Ppp2r3a Rhoa Sox2 Ppp2r2c Dvl1 Ppp2r2b Dvl2 Wnt5a Wnt5b Dvl3 Wnt9b Ppp2cb Ppp2ca Ppard Prkcq Gsk3b Crebbp Prkci Ptpa Prkcd Prkce Axin1 Axin2 Prkca Wnt16 Fbxw2 Lef1 Wnt11 Tcf7 Lrp6 Nlk Nkd2 Lrp5 Wnt6 Wnt3a Tmem97 Wnt7a Wnt2 Tcf7l1 Prkcz Wnt4 Cd44 Wnt3 Pou5f1 Fosl1 Fzd3 Ccnd2 Fzd2 Fzd4 Fzd9 Fzd8 Nanog Ppp2r2a Wnt2b Ppp2r1a Apc Plau Ctnnd1 Ppm1j Mapk10 Prkcb Ccnd1 Tp53 Mapk9 RELATIONSHIP BETWEEN GLUTATHIONE AND NADPH%WIKIPATHWAYS_20260211%WP2562%RATTUS NORVEGICUS Relationship between glutathione and NADPH Dffb Abcc1 Txn1 Gpi Mapk8 Alox5 Eno1 Map3k5 Ftl1 Casp3 Nnt Fth1 Pgam2 Pgm2 Ugdh Pgm1 Ptgr1 G6pd Kif1b Bax Gapdh Pgd Tfr2 Gstp1 Cdkn1a Tp53 Tkt Gapdhl6 Pklr Rpe Taldo1 Dpep2 Aldoa Rpia Pfkl Pgk1 Ugp2 Gclm Ugt8 Ltc4s Nqo1 Gsn Tfrc Gss Gsr Anpep Gck Fas Pgls Dffa TNF ALPHA AND MUCUS PRODUCTION IN LUNG EPYTHELIUM%WIKIPATHWAYS_20260211%WP1487%RATTUS NORVEGICUS TNF alpha and mucus production in lung epythelium Tgfa Ikbkg Tnf Nfkbia Egfr Il6 Tnfrsf1a Muc2 Ripk2 Tradd Ikbkb Rps6ka2 Traf2 Shc1 Raf1 Tlr4 Nfkb1 Mapk1 Map2k1 Grb2 Chuk Rela Sos1 WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP375%RATTUS NORVEGICUS Wnt signaling pathway Jun Raf1 Csnk2a2 Csnk2a1 Mark2 Cdh1 Sox9 Tax1bp3 Rac1 Skp1 Sfrp2 Csnk2b Ctnnb1 Sfrp1 Ctbp1 Dkk1 Map3k7 Ctbp2 Prkcg Magi3 Rhoa Ror2 Crybb2 Csnk1d Dvl1 Btrc Dvl2 Wnt5a Sall1 Cdc25c Dvl3 Senp2 Ruvbl1 Ppp2ca Vangl2 Csnk1a1 Dab2 Gsk3b Camk2g Camk2d Tfap2a Camk2b Camk2a Axin1 Arrb2 Axin2 Arrb1 Prkca Brd7 Jup Map1b Lef1 Ctnnbip1 Ankrd6 Bcl9 Lrp6 Dlg1 Nlk Dlg2 Mapk8ip1 Lrp5 Dlg4 Cul1 Wnt3a Tcf4 Tmem97 Nr5a1 Wnt7a Hipk2 Wnt2 Wnt4 Wnt3 Fzd2 Fzd4 Fzd9 Fzd8 Apc Mapk1 Mapk3 Akt1 Mapk8 Prkcb Ccnd1 Cdk1 Mapk9 Tbp Pax2 Smad4 STATIN PATHWAY%WIKIPATHWAYS_20260211%WP145%RATTUS NORVEGICUS Statin pathway Mttp Soat1 Hmgcr Lpl Apoe Cyp7a1 Lcat Abca1 Scarb1 Apoc1 INTERACTIONS BETWEEN CFTR AND OTHER ION CHANNELS%WIKIPATHWAYS_20260211%WP1485%RATTUS NORVEGICUS Interactions between CFTR and other ion channels Cftr Nherf1 Scnn1b Scnn1g COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP547%RATTUS NORVEGICUS Complement and coagulation cascades Cr2 Serping1 Cr1l Kng2l1 C3ar1 Serpinf2 Plau Mbl1 Fgb Vwf Masp1 Masp2 Tfpi C8b F2 F3 C4a F7 F8 F9 Serpine1 Plaur Cfb C1qb Cfd C1qa Cd59b Cfh Cfi F2r Plg Klkb1 Kng2 C2 Proc C6 C9 Serpind1 F13b Cd46 F10 C1s C1r F12 Plat Thbd Pros1 Serpinc1 A2m Cpb2 Cd55 C1qc TRANSLATION FACTORS%WIKIPATHWAYS_20260211%WP149%RATTUS NORVEGICUS Translation factors Eif3j Pycr3 Eif2s3 Eif2ak1 Eef1g Eif4ebp2 Eif2ak2 Eif3f Eif4ebp1 Eif4g1 Eif2ak3 Eif4g3 Eif3b Eif3a Eif1a Eif5b Eif5a Eif2b3 Eif2b2 Eif2b5 Eif2b4 Kcnq2 Eif2s2 Eef2k Eif2b1 Eif4h Paip1 Eif4e Eif1 Eif1ax Eif6 Eif4a2 Eif4a1 Etf1 Gspt2 Cluh Eef1a2 Eef1d ACETATE MEDIATED PROMOTION OF METABOLIC SYNDROME%WIKIPATHWAYS_20260211%WP3650%RATTUS NORVEGICUS Acetate mediated promotion of metabolic syndrome Ins2 Gast OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260211%WP1283%RATTUS NORVEGICUS Oxidative phosphorylation Mt-nd6 Atp5mc1 Mt-nd1 Ndufb6 Mt-nd3 Mt-nd4l Ndufb5 Mt-nd2 Ndufb8 Ndufb7 Atp5mc3 Atp5mf Atp5me Ndufv1 Ndufv3 Atp5f1a Ndufa10l1 Ndufab1 Ndufc1 Ndufc2 Ndufa2 Ndufa5 Gzmb Ndufa4 Atp5pb Gzmc Ndufa9 Ndufa8 Atp5pf Ndufb10 Atp5po Ndufs3 Ndufs2 Ndufs5 Ndufs4 Ndufs6 Mt-co3 Ndufs8 Mt-nd5 Adck2 Mt-nd4 Ndufb2 Mt-atp6 G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP520%RATTUS NORVEGICUS G13 signaling pathway Arhgef1 Arhgdib Map3k4 Mapk10 Rps6kb1 Iqgap1 Rac1 Pak3 Pik3cd Iqgap2 Cdc42 Ppp1cb Diaph1 Tnk2 Cfl2 Rhpn2 Wasl Sh3rf1 Cit Limk1 Cyfip1 Rock2 Rock1 Mybph Pkn1 Pik3r2 Pip4k2a VEGF RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260211%WP1965%RATTUS NORVEGICUS VEGF receptor signal transduction Prkci Sh2d2a Casp9 Mapkapk2 Bad Nos3 Pxn Shc1 Pgf Raf1 Hspbp1 Prkca Pik3r3 Mapk1 Vegfb Plcg1 Akt1 Grb2 Rac1 Vegfc Src PROXIMAL TUBULE TRANSPORTERS%WIKIPATHWAYS_20260211%WP3881%RATTUS NORVEGICUS Proximal tubule transporters Slc1a1 Atp6v0c Car7 Slc4a4 Slc38a7 Slc34a1 Slc6a19 Slc7a6 Nherf1 Slc7a7 Car2 Atp1b1 Slc9a3 Slc9a8 Slc13a3 Slc7a8 Atp6v1a Slc13a1 Slc34a2 Slc13a2 Slc7a9 Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Slc16a10 Atp6v1g1 Ca4 Slc22a8 Atp6v1d Ca14 Atp6v1h Slc20a2 Slc22a6 Car15 Slc26a1 Atp1a1 Fxyd4 Slc22a5 Tctn2 Atp6v0a2 Atp6v0a4 Atp6v1e1 Atp6v1g3 Atp6v0e2 Atp6v0a1 Nherf2 IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP319%RATTUS NORVEGICUS IL 3 signaling pathway Lck Mapk14 Raf1 Map2k1 Rac1 Hras Atf2 Mapk7 Socs3 Spi1 Ywhaq Birc5 Matk Ppp2ca Crkl Tnfrsf1b Bcl2l11 Gsk3b Csf2rb Kcnip3 Ywhab Rac2 Rara Slc2a1 Jak2 Prkca Jak1 Foxo1 Rap1a Fcer2 Syk Mmp2 Gab1 Bcl2l1 Rack1 Gab2 Mmp9 Dnm1 Hck Rxra Gsk3a Pik3r1 Crk Gata2 Vcl Chek1 Ptpn6 Il3ra Selp Il3 Pak1 Rps6kb2 Hspb1 Ptpn11 Bad Fyn Shc1 Lyn Pik3ca Bmx Mapk1 Ptk2 Stat5a Mapk3 Stat5b Akt1 Tec Fes Rapgef1 Grb2 Mapk8 Stat3 Pik3cd Prkcb Cdc42 Bax Pik3r2 Mapk9 Id1 Mapkapk2 Pxn Nfkb1 Prkaca Sos1 Src SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2541%RATTUS NORVEGICUS Sulindac metabolic pathway Msra Cyp1a1 Msrb2 MISMATCH REPAIR%WIKIPATHWAYS_20260211%WP1295%RATTUS NORVEGICUS Mismatch repair Pold1 Lig1 Pcna Msh2 Rfc1 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260211%WP217%RATTUS NORVEGICUS Nuclear receptors Esr1 Nr3c1 Nr2c2 Nr2e1 Hnf4a Nr1i3 Nr1i2 Esrrb Rarb Nr2f6 Ppard Thrb Nr1d2 Thra Nr2f2 Vdr Nr2f1 Rara Nr1h3 Rorc Nr1h2 Ppara Pparg Esr2 Rxrb Ror1 Rxrg Nr5a2 Nr4a2 Esrra Nr5a1 Rxra NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260211%WP1277%RATTUS NORVEGICUS Non homologous end joining Xrcc6 Rad50 Prkdc Xrcc4 MONOAMINE GPCRS%WIKIPATHWAYS_20260211%WP276%RATTUS NORVEGICUS Monoamine GPCRs Hrh1 Chrm3 Htr6 Chrm2 Htr7 Chrm5 Chrm4 Hrh2 Drd1 Adrb1 Drd3 Drd4 Drd5 Adra1b Adrb3 Adra1d Htr1d Htr1f Htr5b Htr5a Adra1a Htr2a Htr2c Htr1a Adra2a Adra2c Adra2b Htr4 Chrm1 HYPERTROPHY MODEL%WIKIPATHWAYS_20260211%WP442%RATTUS NORVEGICUS Hypertrophy model Myog Atf3 Eif4ebp1 Jund Wdr1 Ankrd1 Hbegf Zeb1 Il1a Dusp14l1 Eif4e Ifng Ifrd1 Il1r1 Ccn1 Nr4a3 THICK ASCENDING LIMB TRANSPORTERS%WIKIPATHWAYS_20260211%WP3882%RATTUS NORVEGICUS Thick ascending limb transporters Slc4a7 Slc12a1 Slc9a2 Aqp1 Kcnk12 Kcnq1 Slc12a7 Kcnj16 Clcnkb Car2 Clcnka Atp1b1 Slc9a3 Atp1a1 Ca4 HYPOTHETICAL NETWORK FOR DRUG ADDICTION%WIKIPATHWAYS_20260211%WP1281%RATTUS NORVEGICUS Hypothetical network for drug addiction Drd1 Drd4 Mapk1 Mapk3 Map2k1 Grin2d Grin2a Grm1 Camk2b Grm5 Prkce Adcy1 Grin1 Adcy8 Acta1 Nisch Krit1 Camk4 Terf2ip Gria2 Gria1 Ppa1 Prkaca Grin2c Grin2b METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260211%WP1286%RATTUS NORVEGICUS Metapathway biotransformation Hs3st6 Cyp2s1 Cyp17a1 Cyp4f39 Baat Naa20 Akr1d1 Kcnab2 Kcnab3 Sult1e1 Cyp2r1 Fmo1 Fmo3 Fmo2 Fmo5 Hs6st3 Fmo4 Hs6st1 Akr1b10 Cyp26c1 Cyp21a1 Gal3st4 Gal3st3 Glyat Cyp7a1 Cyp1a1 Chst10 Akr7a3 Chst11 Chst12 Akr7a2 Cyp2u1 Chst13 Cyp4f18 Chst14 Cyp4f17 Gstk1 Comt Cyp1b1 Ndst1 Cyp4x1 Ndst3 Sult4a1 Cyp26a1 Cyp11b2 Sult1b1 Hs3st3b1 Gstm7 Gstm5 Gstm4 Gstm1 Cyp27b1 Cyp2f2 Gstcd Cyp8b1 Cyp51 Hs2st1 Sult1a1 Tpmt Hnmt Naa50 Cyp46a1 Nat8 Nat1 Cyp2e1 Nat2 Ephx1 Ephx2 Akr1a1 Nat9 Sult2b1 Inmt Sult6b2 Gstp1 Naa40 Ugt2b1 Gsto1 Mgst3 Nat10 Mgst1 Akr1b1 Cyp7b1 Gpx2 Hs3st3a1 Chst1 Sult2a1 Chst3 Sult2a6 Chst4 Chst6 Cyp24a1 Chst9 Gss Naa30 Gsr Akr1c1 Zfp628 Gstz1 Hs3st2 Hs3st5 METHYLATION%WIKIPATHWAYS_20260211%WP1282%RATTUS NORVEGICUS Methylation Comt Inmt Pnmt Mat2a Mat1a Hnmt IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP135%RATTUS NORVEGICUS IL 6 signaling pathway Il6 Eif4ebp1 Rps6ka2 Jun Mapk14 Raf1 Map2k1 Rac1 Hras Erbb2 Map3k7 Ppp2r3b Eif4e Ppp2r3a Hsp90aa1 Hdac1 Foxo4 Mapt Ppp2r2c Foxo3 Ppp2r2b Cd40 Socs3 Cdk5r1 Fgr Btk Ppp2cb Sgk1 Ppp2ca Il6st Ppp2r5c Cebpb Gsk3b Map2k6 Crebbp Ppp2r5b Ptpa Ppp2r5a Prkcd Ncoa1 Il6r Inppl1 Ptk2b Jak2 Eif2a Jak1 Map2k4 Foxo1 Cdk9 Map2k2 Ppp2r5e Cdk5 Hnf1a Gab1 Nlk Daxx Gab2 Tmem97 Hck Pik3r1 Hspb1 Casp9 Ptpn11 Bad Fyn Ppp2r2a Shc1 Lyn Ppp2r1a Bmx Mapk1 Ptk2 Plcg1 Stat5a Mapk3 Stat5b Map3k4 Akt1 Tec Rps6kb1 Fes Grb2 Mapk8 Stat3 Casp3 Fos Pik3r2 Mapkapk2 Pxn Nfkb1 Rb1 Sos1 HEXOSES METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260211%WP3916%RATTUS NORVEGICUS Hexoses metabolism in proximal tubules Pdhx Psme3 Slc5a10 Sord Eno3 Eno2 Khk Pc Mpc1 Mpc2 Pdk4 Slc2a2 Pdk3 Pgam1 Slc2a5 Pdk2 Pdk1 Tpi1 Pdhb Tkfc Ldha Ldhb Fbp1 Dld Aldob Aldoc Acly Pdha1 Slc5a1 Pck1 Gpi Slc5a2 Pfkp Slc5a9 Eno1 Got1 Mdh1 Mdh2 Got2 G6pc1 Pgam2 Hk1 Pdp1 Pdp2 Gapdh Pklr Akr1b1 Aldoa Pfkl Pgk1 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260211%WP502%RATTUS NORVEGICUS Nucleotide GPCRs Adora2b Adora2a P2ry6 Lpar6 Adora1 P2ry2 P2ry1 Lpar4 SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260211%WP1293%RATTUS NORVEGICUS Selenium metabolism selenoproteins Sephs1 Nfe2l2 Trnau1ap Jun Fos Selenbp1 Msrb1 Txnrd2 Rpl30 Eefsec Crem Sp3 Nfkb1 Selenof Sars2 Gpx2 Selenoi Sars1 Selenok Fabp1 Selenoo Selenop Gpx3 Rela Gpx6 Selenos Dio1 Selenot Dio2 Dio3 Selenov Selenow TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260211%WP1280%RATTUS NORVEGICUS Transcriptional activation by Nfe2l2 in response to phytochemicals Nfe2l2 Aimp2 Gclm Maf Hmox1 Nqo1 Mapk8 Ephb2 Cebpb Prkca POLYOL PATHWAY%WIKIPATHWAYS_20260211%WP1303%RATTUS NORVEGICUS Polyol pathway Sord Khk Akr1b1 Aldob RETINOL METABOLISM%WIKIPATHWAYS_20260211%WP1297%RATTUS NORVEGICUS Retinol metabolism Lpl Dhrs3 Aldh1a1 Cd36l1 Rdh12 Cyp26a1 Aldh1a3 Rdh10 Adh5 Adh4 Adh1 Bco1 Npc1l1 Rpe65 Rbp7 Abcg8 Abcg5 Rbp4 Retsat Sult1a1 Crabp2 Cd36 Lrat Rlbp1 Cyp2e1 Sult2b1 Rarb Rara Rxrb Rxrg Rxra Scarb1 BETA OXIDATION OF UNSATURATED FATTY ACIDS%WIKIPATHWAYS_20260211%WP418%RATTUS NORVEGICUS Beta oxidation of unsaturated fatty acids Decr1 Hadha Hadhb Eci1 Acadm TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP457%RATTUS NORVEGICUS TNF alpha NF kB signaling pathway Map3k14 Ikbkg Tnf Nfkbia Tnfrsf1a Ripk2 Tradd Traf2 Csnk2a2 Csnk2a1 Mark2 Csnk2b Hdac1 Btrc Tnfrsf1b Crebbp Ywhab Gab1 Rack1 Cul1 Hspb1 Ptpn11 Ptk2 Akt1 Casp3 Nr2c2 Rpl30 Ikbkb Hdac2 Prkaca Src Chuk Nkiras1 Nkiras2 Tbkbp1 Map3k8 Rps11 Kcnq1 Ppp2ca Rpl6 Rps13 Pias3 Gsk3b Fbl Ube2i Akt2 Dpf2 Polr1b Rnf216 Polr1a Polr1g Fbxw11 Polr1e Casp8ap2 Txlna Tank Gtf2i Map3k3 Actl6a Map3k2 Map3k1 Smarce1 Tifa Ube2d2 Polr2sl1 Flna Prkcz Cdc34 Nfkbiz Glg1 Bag4 Ripk3 G3bp2 Dcaf7 Cops3 Nfkbib Cav1 Capn3 Kpna6 Ripk1 Mcc Kpna3 Kpna2 Dap Bcl3 Rel Tab2 Rps6kb1 Ccar2 Traf4 Mcm7 Pfdn2 Traf6 Faf1 Tnfrsf8 Ywhah Ikbke Ywhag Psmd12 Ywhae Smarcb1 Psmd13 Nfkb2 Alpl Rasal2 Akap8 Psmb5 Rpl8l1 Pkn1 Cyld Fkbp5 Mcm5 Fadd Tnip2 Tnip1 Psmc2 Nfkb1 Psmc3 Pdcd2 Nsmaf Zfand5 Commd1 Trpc4ap Psmd7 Casp7 Rela Psmd6 Fancd2 Psmd3 Elp1 Casp2 Ktn1 Pebp1 Lrpprc Mtif2 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP1284%RATTUS NORVEGICUS EPO receptor signaling Socs1 Ptprc Epo Rasa1 Irs2 Ptpru Pdk1 Shc1 Raf1 Jak2 Mapk1 Stat5a Mapk3 Map2k2 Map2k1 Stat5b Akt1 Pik3cg Grb2 Stat3 Sos1 Src INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP40%RATTUS NORVEGICUS Inflammatory response pathway Cd40 Lck Col1a2 Tnfrsf1b Tnfrsf1a Cd86 Col1a1 Cd40lg Il4r Cd80 Il2ra Il2rb Il2 Il4 Lama5 Vtn Il2rg Il5 Il5ra Lamc1 Lamb1 Thbs1 Ifng MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260211%WP140%RATTUS NORVEGICUS Myometrial relaxation and contraction pathways Atf3 Il6 Prkd1 Ets2 Rgs4 Rgs5 Prkcg Rgs2 Gja1 Rgs3 Atf2 Rgs1 Crcp Slc8a1 Rgs9 Rgs6 Ywhaq Rgs7 Plcg2 Actb Myl4 Mylk2 Camk2g Prkch Camk2d Myl2 Rxfp2 Ywhab Camk2b Rxfp1 Camk2a Atf5 Arrb2 Maff Arrb1 Pkib Calca Grk5 Grk4 Atf6b Gnaq Prkar1b Pkia Grk6 Pkig Actg1 Oxtr Gabpa Gucy1a1 Dgkz Gnb2 Gnb4 Gnb3 Rln1 Gng12 Itpr3 Gng13 Itpr1 Ryr2 Plcb3 Atp2a3 Atp2a2 Oxt Adm Adcy3 Adcy4 Nos1 Nos3 Adcy2 Guca2b Adcy7 Guca2a Plcg1 Crhr1 Adcy5 Lpar1 Creb3 Adcy9 Cald1 Pde4b Prkacb Prkar1a Rgs20 Rgs17 Igfbp3 Gng3 Rgs19 Gng2 Igfbp4 Vkorc1l1 Rgs14 Gng7 Igfbp1 Rgs16 Pde4d Gng8 Actc1 Prkar2b Rgs10 Ackr5 Corin Ramp3 Il1b Gngt1 Jun Gnb1 Prkcq Prkcd Prkce Adcy1 Prkca Acta1 Prkcz Prkcb Ywhah Crh Ywhag Fos Ywhae Gsto1 Nfkb1 EBV LMP1 SIGNALING%WIKIPATHWAYS_20260211%WP1278%RATTUS NORVEGICUS EBV LMP1 signaling Map3k14 Nfkb2 Tradd Ikbkb Pdlim7 Nfkb1 Mapk1 Ifnb1 Ccl5 Mapk8 Chuk Rela Traf6 Map3k7 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260211%WP270%RATTUS NORVEGICUS Tryptophan metabolism Aadat Cyp2d2 Ogdh Aanat Afmid Cyp1b1 Gcdh Aoc1 Dhcr24 Aldh1a1 Haao Asmt Echs1 Kynu Cat Mdm2 Cyp2a2 Cyp2a1 Ube3a Acmsd Ido1 Cyp2f2 Hadh Cyp1a1 Cyp2e1 Inmt Cyp7b1 Ddc Tph1 Aldh3a2 Aldh2 Aldh9a1 Acad10 Cyp2j3 Hsd17b10 Cyp2b15 Wars1 Cyp2j4 Prmt1 Tdo2 Cyp4f1 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP504%RATTUS NORVEGICUS Fatty acid biosynthesis Decr1 Acss2 Acaca Echs1 Acly Hadh Mecr Echdc3 Echdc1 Echdc2 Acaa2 Acsl1 Scd Fasn Acsl5 Acsl6 Pc Acsl3 Acacb GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260211%WP378%RATTUS NORVEGICUS GPCRs class B secretin like Calcr Adgre5 Ghrhr Gipr Gcgr Adgre1 Adgrl2 Adgrl3 Sctr Adgrl4 Adcyap1r1 Adgrl1 Glp2r Vipr1 Calcrl Glp1r Crhr2 Crhr1 BRAIN DERIVED NEUROTROPHIC FACTOR%WIKIPATHWAYS_20260211%WP2148%RATTUS NORVEGICUS Brain derived neurotrophic factor Mapk1 Ngfr Map2k1 Ntrk2 Bdnf Plat Plg Raf1 Serpine1 TOLL LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP1309%RATTUS NORVEGICUS Toll like receptor signaling pathway Ikbkg Tnf Nfkbia Il6 Cd86 Cd80 Jun Mapk14 Tlr4 Map2k1 Rac1 Chuk Map3k7 Cd40 Map3k8 Map2k6 Akt2 Map2k4 Il12b Il12a Ticam2 Akt3 Lbp Ly96 Tlr1 Ifna4 Irf3 Ifna1 Pik3r5 Pik3r1 Irf7 Tlr8 Irf5 Tlr7 Tlr6 Tlr5 Tlr3 Tlr2 Cxcl11 Cxcl10 Map2k7 Ifnar1 Cxcl9 Ripk1 Ccl4 Ccl3 Pik3ca Spp1 Mapk1 Mapk13 Tollip Mapk3 Map2k3 Akt1 Tab2 Cd14 Mapk10 Pik3cg Mapk8 Pik3cd Traf6 Ikbke Fos Nfkb2 Pik3r2 Mapk9 Ikbkb Fadd Il1b Nfkb1 Pik3r3 Ifnb1 Ccl5 Rela TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260211%WP1289%RATTUS NORVEGICUS Type II interferon signaling IFNG Socs1 Eif2ak2 Cxcl10 Ptpn11 Cxcl9 Ifngr2 Oas1a Ifngr1 Psmb9 Gbp1 Nos2 Tap1 Ifng Ciita Irf4 Reg1a Cybb Irf1 Irf2 Socs3 Irf8 Spi1 Isg15 Hist1h2ao Irf9 Ifit2 Prkcd Il1b Jak2 Ifnb1 Jak1 CFTR ACTIVITY IN THE PLASMA MEMBRANE%WIKIPATHWAYS_20260211%WP1488%RATTUS NORVEGICUS CFTR activity in the plasma membrane Ppp2ca Plcb3 Plcz1 Cftr Plcb2 Plcb1 Nherf1 Prkaa2 Snap23 Pdzk1 Ezr Prkaca Rack1 Prkcg Nherf2 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260211%WP473%RATTUS NORVEGICUS GPCRs class A rhodopsin like Gpr174 Galr2 Gpr171 Galr3 Galr1 Cmklr1 Lhcgr Sstr5 Sstr4 Sstr3 Sstr2 Olr226 Sstr1 Avpr1b Mc5r Oprm1 Gpr75 Tbxa2r C5ar2 Or7c70 Ffar3 Fpr1 Aplnr Bdkrb2 Nmbr Fpr3 Ffar1 Bdkrb1 Fpr2 Ffar2 Ccr10 Ptgfr Or2b2 Or2j3 Hrh3 Agtr1a Or5v1b Gpr85 Or7a36 Opn4 Xcr1 Lpar5 Opn3 Olr1073 Gpr19 Sucnr1 Gpr18 Grpr Or6b1 Gpr15 Or2c1 Gpr17 Or13c7d Or5i1 Gpr12 Adora3 Or2t1 Oxtr Cckar Opn1sw Npbwr1 Nmur2 Prlhr Npy5r Ntsr2 Ntsr1 Brs3 Gpr25 Ptger4 Mc2r Gpr27 Ptger2 Gpr22 Ptger3 Gpr21 Fshr Ptger1 Ccr9 Mchr1 Ccr7 C3ar1 Ccr6 Ccr5 Ccr3 Ccr2 Mtnr1a Cckbr Agtr2 Npy4r Gpr37 Ptgir Gpr39 Or11a4 Rgr Or14j1 Or3a1e Mc4r Or10j27 Adora2b Ptafr Adora2a Npffr1 P2ry6 Or2f2 Lpar6 Npffr2 Adora1 Ptgdr2 P2ry2 Or2f1 P2ry1 Rho F2r Lpar4 Hcrtr1 Or5ap2b Or2w1 Gpr37l1 Cysltr2 Cysltr1 Npy2r Ackr4 Cnr1 Gpr4 Cnr2 Gpr3 Ackr2 Gpr6 P2ry10 Mc3r Or2ag1 P2ry13 P2ry12 P2ry14 Adra2a Mas1 Adra2c F2rl1 Adra2b Or10a4 Htr4 Gpr50 Chrm1 Oprk1 Hrh1 Or10a5 Chrm3 F2rl2 Htr6 F2rl3 Chrm2 Htr7 Chrm5 Chrm4 Hrh2 Drd1 Adrb1 Drd3 Drd4 Drd5 Adra1b Adrb3 Adra1d Gper1 Htr1d Htr1f Htr5a Adra1a Htr2a Htr2c Htr1a Hcar1 Ghsr Ednrb Gpr161 Ednra Cxcr1 Npy1r Rrh Ptgdr Or3a1 Oprd1 Or2h2 Gpr65 Or2h1 Gpr68 Cxcr4 Gpr63 Oprl1 Gpr173 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260211%WP139%RATTUS NORVEGICUS Nuclear receptors in lipid metabolism and toxicity Abcb1a Abcd2 Abcc2 Abcd3 Cyp7a1 Cyp2c11 Abcb4 Cyp4b1 Cyp2b2 Abcg1 Cyp26a1 Abcc3 Abcb11 Cyp27b1 Cyp8b1 Abcg5 Cyp2e1 Nr1i3 Nr1i2 Rarb Ppard Vdr Rara Nr1h3 Ppara Pparg Cyp24a1 Abca1 SPINAL CORD INJURY%WIKIPATHWAYS_20260211%WP2433%RATTUS NORVEGICUS Spinal cord injury Il6 Btg2 Fkbp1a Tlr4 Il2 Ptprz1 Il4 Slit1 Slit2 Aqp4 Slit3 Sox9 Pdyn Rhoc Rgma Vcan Sema6a Lilrb2 Il1a Tnfsf13b Ifng Zfp36 Gap43 Gja1 Arg1 Il1r1 Prpg2 Omg Plxna2 Epha4 Mag Rtn4r Tacr1 Anxa1 Pla2g2a Ccng1 Ntn1 Klk8 Rtn4 Gfap Bcan Tnfsf13 C5 Grin1 Prkca Tgfb1 Gdnf Ccl2 Ngfr Pla2g5 Mbp Bdnf Cd47 Cxcl1 Cxcl2 Pla2g6 Fcgr2a Egr1 Mmp9 Ptpra Chst11 Ncan Col4a1 Acan Xylt1 Nox4 Vim E2f5 Selp Cxcl10 Nos1 Mapk1 Mapk3 Ppp3ca Nos2 Casp3 Ccnd1 Fos Gadd45a Necab3 E2f1 Rock2 Cdk1 Tp53 Il1b Rb1 KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP147%RATTUS NORVEGICUS Kit receptor signaling pathway Socs1 Rasa1 Ptpru Raf1 Map2k1 Hras Fgr Btk Matk Crkl Csf2rb Jak2 Prkca Hck Pik3r1 Crk Stap1 Mitf Grb10 Ptpn6 Socs5 Socs4 Socs6 Cltc Sh3kbp1 Cblb Vav2 Ptpn11 Bad Dok1 Fyn Rps6ka1 Shc1 Lyn Kit Tnfrsf10b Mapk1 Spred1 Plcg1 Mpdz Stat5a Spred2 Stat5b Akt1 Grb7 Tec Abl1 Pik3cg Fes Grap Grb2 Plce1 Stat3 Sh2b2 Prkcb Pik3r2 Sos1 Src HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP94%RATTUS NORVEGICUS Hepatocyte growth factor receptor signaling Crk Rasa1 Pak1 Ptpn11 Jun Raf1 Pik3ca Mapk1 Ptk2 Mapk3 Map2k1 Rapgef1 Grb2 Mapk8 Stat3 Dock1 Hras Itga1 Rap1b Hgf Pten Map4k1 Fos Itgb1 Met Elk1 Crkl Pxn Ptk2b Rap1a Map2k2 Gab1 Sos1 Src PROTEASOME DEGRADATION%WIKIPATHWAYS_20260211%WP302%RATTUS NORVEGICUS Proteasome degradation Psmb9 Psmd12 Psmc6 Psmc5 Psmd13 Psma5 Rpn2 Psma2 Psmc4 Rpn1 Psmb5 Psme2 Psme1 Psmd11 Ube2b Uchl3 Psmb8 Psmb6l1 Psmc2 Psmb4 Psmc3 Psmb7 Psmd8 Uchl1 Psmb1 Psmd2 Psmd4 Psmd5 Psmd7 Psmb2 Ube2d3 Psmd6 Ube2d1 Psma7 Psmd3 TCA CYCLE%WIKIPATHWAYS_20260211%WP347%RATTUS NORVEGICUS TCA cycle Suclg2 Pdk4 Ogdh Pdk3 Pdk2 Pdhb Dld Pdha1 Fh Mdh1 Mdh2 Sdhc Sdhb Sdha Idh3b Afdn Pc Suclg1 NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP1294%RATTUS NORVEGICUS Nod like receptor NLR signaling pathway Cd40 Ikbkg Mapk8 Chuk Ephb2 Rela Ikbkb Map3k7 OSTEOCLAST%WIKIPATHWAYS_20260211%WP489%RATTUS NORVEGICUS Osteoclast Ifnb1 Trpv5 Itgb3 Zcchc2 Ctsk Tnfsf11 Slc9a1 Atp6v1e1 Ifnar1 Spp1 HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP574%RATTUS NORVEGICUS Hedgehog signaling pathway Cdk1 Hhip Igf2 Crebbp Gli1 Gli3 Gli2 Ski Ptch2 Smo Ptch1 Sufu Sap18 Dyrk1a Ccnb1 P53 PATHWAY%WIKIPATHWAYS_20260211%WP655%RATTUS NORVEGICUS p53 pathway Chek1 Casp9 Sesn1 Zmat3 Serpinb5 Cdkn2a Bid Shisa5 Sfnl1 Tp73 Ccnb1 Adgrb1 Casp3 Cd82 Igfbp3 Cycs Tsc2 Pten Chek2 Perp Gadd45a Serpine1 Mdm4 Ppm1d Cdk6 Rchy1 Pmaip1 Bax Ccne1 Cdk1 Ccng1 Cdkn1a Tp53 Rprm Fas G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260211%WP348%RATTUS NORVEGICUS G1 to S cell cycle control Mdm2 Cdk7 Ccna1 Ccne2 Cdkn2b Tfdp1 Cdkn2c Cldn5 Myt1 Mcm4 Mcm6 Mcm2 Pole2 Pola2 Ccng2 Creb3l4 Creb3l1 Orc5 Rpa3l1 Orc4 Orc6 Atf6b Orc1 Orc3 Rpa2 Wee1 E2f2 E2f3 E2f4 Cdkn1b E2f6 Pole Cdkn1c E2f5 Creb3 Mcm7 Ccnb1 Pcna Ccnd1 Gadd45a Necab3 Cdk6 Ccne1 E2f1 Cdk1 Cdkn1a Tp53 Mcm5 Mnat1 Rb1 Ccnh Rbl1 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP66%RATTUS NORVEGICUS Steroid biosynthesis Hsd3b5 F13b Hsd3b2 Hsd17b3 Cyp17a1 Hsd3b1 Hsd17b4 Hsd17b1 Hsd17b2 Hsd17b7 ANGIOTENSIN II SIGNALING ACUTE IN THICK ASCENDING LIMBS%WIKIPATHWAYS_20260211%WP3887%RATTUS NORVEGICUS Angiotensin II signaling acute in thick ascending limbs Itpr3 Itpr1 Calm2 Pdpk1 Pde2a Agtr1b Itpr2 Nos3 Agtrap Plcg1 Akt1 Agtr2 Prkcg Pten Agtr1a Plcg2 Akt2 Arrb2 Prkca Gnaq Prkaca Akt3 Dnm1 Mas1 Nox4 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260211%WP351%RATTUS NORVEGICUS Regulation of actin cytoskeleton Egfr Slc9a1 Raf1 Rac1 Actb Actg1 Pik3r1 Gng12 Crk Vcl Pak1 Ins1 Fgf2 Pik3ca Fgf1 Mapk1 Fgf4 Ptk2 Fgf3 Mapk3 Mapk4 Fgf6 Fgf5 Pik3cg Fgf8 Fgf7 Fgf9 Cfl1 F2 Nras Pip4k2b Pfn1 Arhgef7 Arhgef6 Myh10 Nckap1 Pdgfrb Pdgfra Pdgfa Rras2 Pik3c2b Pik3c2a Ssh3 F2r Fgfr3 Pik3c2g Ssh2 Fgfr4 Ssh1 Fgfr1 Fgfr2 Braf Mylk Cyfip2 Arpc5 Fgf16 Fgf14 Fgf18 Fgf19 Fgf12 Fgf13 Pik3c3 Fgf10 Fgf11 Enah Sos1 Baiap2 Git1 Fgf20 Fgf23 Chrm1 Rras Rassf7 Chrm3 Sos2 Gna12 Chrm2 Gna13 Fgd1 Chrm5 Bcar1 Chrm4 Pak6 Csk Pak2 Pak5 Pak4 Tmsb4x Arhgap35 Wasf2 Wasf1 Mos Pip5k1b Pip5k1a Map2k1 Rhoa Ins2 Pik3r5 Apc Arhgef1 Cd14 Iqgap1 Pak3 Pik3cd Dock1 Itga1 Cdc42 Cfl2 Limk1 Rock1 Pik3r2 Pip4k2a Ezr Pxn Pik3r3 Egf Gsn PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260211%WP303%RATTUS NORVEGICUS Prostaglandin synthesis and regulation Ptger4 Ptger2 Ptger3 Ptger1 Anxa8 Anxa6 Pla2g4a Prl Ptgds Cyp11a1 S100a6 Ptgir Scgb1a1 Hsd11b1 Hsd11b2 Tbxas1 Edn1 Hpgd Ptgfr Ptgis Anxa5 Anxa4 Anxa3 S100a10 Ptgs1 Anxa1 Ptgs2 Ednrb Ednra Ptgdr BURN WOUND HEALING%WIKIPATHWAYS_20260211%WP5057%RATTUS NORVEGICUS Burn wound healing Epo Col1a1 Jun Ankrd1 Dll4 Casp3 Ptgis Adora2b Pdgfa Il10 Arfgap1 Ccn2 Tp53 Gpr176 Chp1 Syp Il1rl1 Glb1 Il1b Cdc25b Acta1 Syk Igf1 Mmp9 Col4a1 GPCRS OTHER%WIKIPATHWAYS_20260211%WP409%RATTUS NORVEGICUS GPCRs other Or10a5 Chrm3 Chrm2 Htr7 Sstr2 Drd3 Drd4 Smo Adra1d Htr1f C5ar2 Ptgfr Ghrhr Adgrl2 Adgrl3 Gpr176 Grm1 Rxfp1 Gpr18 Prokr2 Grpr Gpr162 Adgrg1 Gnrhr Grm8 Gpr17 Gpr61 Or1n1 Alg6 Gpr135 Taar3 Rxfp3 Taar2 Taar5 Gpr183 Or2a5 Hrh4 Gpr88 Ntsr1 S1pr1 Celsr2 Uts2r Ltb4r2 Lgr6 Or10a2 Fshr Ccr5 Ccr2 Cckbr Htr2a Or3a1e Adora2a Or2f1 F2r Cnr1 Ednra Cxcr1 P2ry13 MRNA PROCESSING%WIKIPATHWAYS_20260211%WP529%RATTUS NORVEGICUS mRNA processing Srsf1 Ptbp2 Srsf9 Srsf7 Srsf6 Srsf5 Srsf4 Srsf3 Srsf2 Srek1 Srsf10 Srrm1 Rbm17 Linc00176 U2af1 Nxf1 Sf3a1 Sf3a2 Sf3a3 U2af2 Ncbp2 Ncbp1 Cd2bp2 Rbmx Snrpd1 Tra2b Celf4 Celf2 Pabpn1 Celf1 Snrpd3 Sf3b2 Sf3b3 Sf3b4 Rbm39 Sfswap Sf3b5 Srp54 Hnrnph2 Ppm1g Hnrnph1 Dicer1 Ddx20 Rngtt Smc1a Prmt1 Prpf4 Phf5a Prpf6 Prpf3 Prpf40a Scamp3 Hnrnpa2b1 Supt5h Cdc40 Rnmt Snrnp70 Clp1 Snrpb2 Xrn2 Spop Prpf8 Prpf18 Snrnp40 Dhx8 Hnrnpr Dhx9 Hnrnpu Papola Snrpb Snrpa1 Snrpa Clk2 Clk3 Clk4 Mettl3 Prp4k Ptbp1 Fus Sugp1 Sugp2 Srpk1 Cpsf4 Lsm7 Cpsf1 Hnrnpd Cpsf2 Cpsf3 Ddx1 Snrpepl2 Hnrnpk Hnrnpm Hnrnpab Cstf1 Ybx1 Clasrp Nudt21 Tmed10 Sfpq Prmt2 Cstf2 Dhx16 Cstf3 Dhx15 BETA OXIDATION META PATHWAY%WIKIPATHWAYS_20260211%WP372%RATTUS NORVEGICUS Beta oxidation meta pathway Acss2 Lpl Gcdh Tpi1 Echs1 Dld Hadh Acsl1 Hadha Acsl5 Hadhb Acsl6 Acsl3 Acadm Pnpla2 Acadvl Acat1 Crat Cpt2 Acads Cpt1a Lipe Gpd2 Lipf Acsl4 MIR219 IN OLIGODENDROCYTE DIFFERENTIATION AND MYELINATION%WIKIPATHWAYS_20260211%WP2811%RATTUS NORVEGICUS mir219 in oligodendrocyte differentiation and myelination Pdgfra Hes5 Zbtb18 Foxj3 Elovl7 Neurod1 Sox6 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260211%WP360%RATTUS NORVEGICUS Acetylcholine synthesis Pemt Pdha1 Ache Pcyt1a Ahsg SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260211%WP349%RATTUS NORVEGICUS Synthesis and degradation of ketone bodies Hmgcl Bdh1 Oxct1 Hmgcs2 IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP569%RATTUS NORVEGICUS IL 2 signaling pathway Lck Socs1 Irs2 Il2ra Eif3b Mapk14 Raf1 Il2 Il2rg Map2k1 Chuk Ets2 Eif4e Foxo3 Socs3 Crkl Ptk2b Jak2 Jak1 Syk Rack1 Gab2 Pik3r1 Prkcz Crk Ptpn6 Jak3 Stam2 Cd53 Itm2b Stam Mtor Ptpn11 Nmi Fyn Mknk1 Shc1 Lyn Pik3ca Mapk1 Stat5a Mapk3 Stat5b Akt1 Rps6kb1 Pik3cg Grb2 Mapk8 Stat3 Pik3cd Nr3c1 Plcb1 Pik3r2 Mapk9 Mapkapk2 Nfkb1 Ybx1 Rela Sos1 Tert LIPID DROPLET METABOLISM%WIKIPATHWAYS_20260211%WP3901%RATTUS NORVEGICUS Lipid droplet metabolism Soat1 Lpin3 Pnpla2 Aup1 Gpat2 Lipa Lpin1 Plin2 Bscl2 Dgat2 Agpat5 Gpd2 Dgat1 Agpat3 Fitm2 Acsl1 Agpat4 Agpat1 Agpat2 Acsl3 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260211%WP133%RATTUS NORVEGICUS Fatty acid omega oxidation Aldh2 Acad10 Aldh1a1 Cyp1a1 Cyp4a2 Cyp3a2 Adh5 Adh4 Adh7 Adh1 Cyp2e1 Adh6 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260211%WP469%RATTUS NORVEGICUS Glutathione metabolism Ggt5 Gstm5l G6pd Gstm6 Gstm3 Gstm2 Gstt2 Gstt1 Ggt1 Oplah Gpx2 Gclm Gpx3 Gss Gsr Anpep GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260211%WP42%RATTUS NORVEGICUS GPCRs class C metabotropic glutamate pheromone Gprc5b Gprc5a Casr Grm1 Gprc5d Grm5 Gprc5c Grm3 Grm2 Grm4 Grm7 Gabbr1 Grm6 Grm8 Gabbr2 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260211%WP557%RATTUS NORVEGICUS ACE inhibitor pathway Ace Agtr2 Ren Bdkrb2 Agt Agtr1b Kng2 Nos3 Kng2l1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260211%WP173%RATTUS NORVEGICUS Oxidative stress response Hmox1 Gstt2 Txnrd2 Mapk14 Cat Mgst1 Nfkb1 Mapk10 Nqo1 Gpx3 Nfix Cyp1a1 Sod3 Gsr Sod2 Sod1 Txn2 Cyba Fos Junb Xdh AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260211%WP1300%RATTUS NORVEGICUS Aflatoxin B1 metabolism Gstm1 Ephx1 Akr7a3 Akr7a2 GLUCOCORTICOID METABOLISM%WIKIPATHWAYS_20260211%WP305%RATTUS NORVEGICUS Glucocorticoid metabolism Akr1c14 Cyp17a1 Cyp21a1 Cyp11a1 Hsd11b1 Hsd11b2 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260211%WP1312%RATTUS NORVEGICUS S1P receptor signal transduction S1pr1 Smpd2 Mapk12 Asah1 Pik3c2b Sphk2 Plcb3 Sphk1 Gnai1 Plcb2 S1pr3 Plcb1 Gnai3 Akt2 Mapk1 Mapk3 Mapk4 Akt1 Akt3 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260211%WP146%RATTUS NORVEGICUS Nucleotide metabolism Polg Adss2 Sat1 Srm Dhfr Pold1 Prps2 Polb Impdh1 Nme2 Mthfd2 Hprt1 IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP44%RATTUS NORVEGICUS IL 5 signaling pathway Socs1 Nfkbia Jun Mapk14 Raf1 Il5 Rap1gap Pla2g4a Il5ra Itgam Rac1 Pim1 Sox4 Sdcbp Hras Ctnnb1 Alox5ap Hcls1 Itgb2 Unc119 Atf2 Foxo3 Btk Crkl Gsk3b Prkcd Ptk2b Jak2 Jak1 Syk Cdkn1b Hck Gsk3a Pik3r1 Ptpn6 Ptpn11 Rps6ka1 Shc1 Lyn Mapk1 Stat5a Mapk3 Stat5b Akt1 Pik3cg Rapgef1 Grb2 Stat3 Alox5 Sh2b2 Prkcb Bax Elk1 Pik3r2 Mapk9 Nfkb1 Shc2 P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP294%RATTUS NORVEGICUS p38 Mapk signaling pathway Tradd Hspb1 Traf2 Mapk14 Ripk1 Mknk1 Shc1 Pla2g4a Rac1 Grb2 Hras Map3k5 Cdc42 Map3k7 Max Map3k9 Atf2 Mef2d Tgfb2 Mapkapk5 Rps6ka5 Tgfbr1 Elk1 Map2k6 Mapkapk2 Map2k4 Daxx Map3k1 INSULIN INDUCED PI3K AKT AND MAPK IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP4229%RATTUS NORVEGICUS Insulin induced PI3K Akt and MAPK in hepatocytes Grb10 Irs2 Eif4ebp1 Mtor Bad Ins1 Shc1 Rps6ka1 Raf1 Mapk1 Acly Mapk3 Akt1 Rps6kb1 Grb2 Eif4e Tsc2 Rptor Pfkfb2 Gys1 Gys2 Rheb Foxk1 Akt1s1 Rps6 Tsc1 Mlst8 Foxo1 Pik3c3 Sos1 Gsk3a ADIPOGENESIS%WIKIPATHWAYS_20260211%WP155%RATTUS NORVEGICUS Adipogenesis Socs1 Tnf Srebf1 Irs2 Il6 Ncor2 Celf1 Dvl1 Socs3 Il6st Cebpb Ncoa1 Rara Foxo1 Lipe Hnf1a Ppargc1a Rxra Gata2 Lpl Lpin3 Stat5a Lpin1 Stat5b Plin2 Bscl2 Pck1 Stat3 Agpat2 Serpine1 Nr3c1 Gadd45a Necab3 Cfd E2f1 Cdkn1a Nr2f1 Nr1h3 Ppara Pparg Rxrg Agt Scd Ptgis Mef2d Wnt5b Ins2 Ppard Nampt Nrip1 Tgfb1 Trib3 Ahr Lifr Prlr Foxc2 Twist1 Ebf1 Mif Retn Lmna Mbnl1 Frzb Cntfr Gata3 Gata4 Gh1 Hif1a Gtf3a Ndn Cisd1 Pck2 Egr2 Lif Bmp4 Bmp3 Wwtr1 Cyp26a1 Bmp1 Hmga1 Plin1 Adipoq Epas1 Slc2a4 Sfrp4 Klf15 Ncor1 Ucp1 Gadd45b Pnpla3 Cebpd Ncoa2 Zmpste24 Asip Osm Dlk1 Mixl1 Mef2a Mef2b Klf6 Mef2c Klf5 Lep Spock1 Gdf10 Id3 Rb1 Igf1 Rbl2 Bmp2 Rbl1 Fas PEPTIDE GPCRS%WIKIPATHWAYS_20260211%WP131%RATTUS NORVEGICUS Peptide GPCRs Galr2 Galr3 Galr1 Lhcgr Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Avpr1b Mc5r Oprm1 Fpr1 Bdkrb2 Nmbr Fpr3 Bdkrb1 Fpr2 Ccr10 Agtr1a Tacr1 Grpr Gnrhr Cckar Oxtr Npy5r Ntsr2 Ntsr1 Brs3 Mc2r Fshr Ccr7 C3ar1 Ccr6 Ccr5 Ccr3 Ccr2 Cckbr Agtr2 Npy4r Mc4r Cxcr6 Tacr3 Tacr2 Tshr Tac4 Npy2r Ghsr Ednrb Ednra Cxcr1 Npy1r Mc3r Oprd1 Cxcr4 Oprl1 Oprk1 GENETIC ALTERATIONS OF LUNG CANCER%WIKIPATHWAYS_20260211%WP1968%RATTUS NORVEGICUS Genetic alterations of lung cancer Tgfb2 Ccne1 E2f1 Egfr Cdkn1a Crebbp Tp53 Bmyc Dmp1 Rasl11b Smad2 Mdm2 Raf1 Pik3ca Tgfb1 Mapk1 Rb1 Map2k1 Akt1 Pik3cd Erbb2 Ccnd1 Smad4 Necab3 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260211%WP227%RATTUS NORVEGICUS Osteoblast signaling Pdgfrb Pdgfra Slc34a1 Tnfsf11 Col1a1 Bglap Fgf23 Pth WNT MYOFIBROBLASTIC ACTIVATION OF HEPATIC STELLATE CELLS%WIKIPATHWAYS_20260211%WP3649%RATTUS NORVEGICUS Wnt myofibroblastic activation of hepatic stellate cells Pparg Wnt3a PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260211%WP282%RATTUS NORVEGICUS Pentose phosphate pathway G6pd Kif1b Pgd Tkt Rpe Taldo1 Pgls Rpia FRUCTOSE METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260211%WP3894%RATTUS NORVEGICUS Fructose metabolism in proximal tubules Slc2a5 Tpi1 Tkfc Fbp1 Aldoa Akr1b1 Aldob Pfkl Naglt1 Gpi Pfkp Slc5a9 Psme3 Slc5a10 Sord G6pc1 Hk1 Khk FOLIC ACID NETWORK%WIKIPATHWAYS_20260211%WP1311%RATTUS NORVEGICUS Folic acid network Msrb1 Txnrd2 Cat Fads2 Mt-co1 Gpx1 Selenok Mtr Kmo Tbxt Ptgds Gpx3 Alox5 Cbs Gpx6 Pnpo Mt-co2 Gsr Mthfr Sod1 Selenow Ptgis Xdh STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260211%WP316%RATTUS NORVEGICUS Striated muscle contraction Tmod1 Vim Acta2 Tpm4 Tpm3 Tpm2 Neb Tnni3 Tnni2 Tnni1 Myh3 Actn2 Actn3 Mybpc3 Myh8 Actn4 Myl9 Myh6 Actc1 Myl2 Acta1 Actg1 Tnnt3 Tnnt2 Tnnt1 Tnnc2 Tnnc1 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260211%WP278%RATTUS NORVEGICUS Matrix metalloproteinases Tnf Mmp11 Cep295nl Mmp23 Mmp24 Mmp14 Mmp2 Mmp15 Mmp16 Mmp28 Mmp17 Timp3 Mmp9 Timp2 Timp4 Bsg Tcf20 Mmp21 GLYCOGEN METABOLISM%WIKIPATHWAYS_20260211%WP160%RATTUS NORVEGICUS Glycogen metabolism Calm2 Ppp2r2a Ppp2r1a Ppp2r3a Ppp2r2c Gbe1 Ppp2r2b Pgm1 Phkb Phka1 Phka2 Gyg1 Ppp2cb Ppp2ca Pygb Gys1 Phkg1 Gys2 Phkg2 Agl Gsk3b Ppp2r5b Pygm Ppp2r5a Ptpa Ugp2 Gsk3a MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP358%RATTUS NORVEGICUS MAPK signaling pathway Map3k14 Ikbkg Rasa1 Egfr Tnfrsf1a Traf2 Raf1 Rac1 Prkcg Mapt Atf2 Crkl Map2k6 Cacng8 Cacna1g Cacna1h Cacna1e Arrb2 Cacng7 Arrb1 Cacna1f Cacna1c Map2k4 Cacna1d Cacna1a Rap1a Cacna1b Cacng1 Cacng4 Map3k6 Daxx Cacng5 Mapk8ip1 Cacng3 Cacna1s Map3k20 Lamtor3 Rasgrp3 Rasgrp4 Rasgrp1 Flnc Rasgrp2 Gng12 Crk Flnb Stmn1 Stk4 Map4k4 Map4k3 Tgfb3 Nf1 Ppp3cc Pak1 Ppp3cb Hspb1 Map4k2 Rasgrf2 Faslg Mknk1 Ppp5c Fgf2 Pla2g4b Fgf1 Pla2g4e Mapk1 Fgf4 Pla2g4d Fgf3 Nfatc1 Mapk3 Nfatc3 Fgf6 Akt1 Rps6ka3 Fgf5 Rps6ka4 Fgf8 Grb2 Cacna2d1 Fgf7 Cacna2d3 Fgf9 Cacna2d4 Prkacb Dusp16 Nras Ptpn7 Ptpn5 Casp3 Dusp3 Ntf4 Dusp2 Gadd45a Hspa1l Dusp4 Pdgfrb Ntf3 Dusp10 Pdgfa Dusp9 Rras2 Dusp8 Cacnb4 Cacnb1 Cacnb2 Fgfr3 Taok2 Tp53 Taok1 Taok3 Mapk9 Fgfr4 Ntrk1 Ikbkb Rapgef2 Fgfr1 Mapk8ip3 Fgfr2 Braf Il1r2 Il1b Map3k11 Map3k13 Fgf16 Fgf14 Fgf18 Fgf19 Fgf12 Fgf13 Prkaca Fgf10 Fgf11 Sos1 Fgf20 Rras Sos2 Gna12 Pak2 Jun Mapk14 Mos Map2k1 Jund Pla2g4a Chuk Hras Il1a Map3k7 Il1r1 Tgfb2 Mapkapk5 Tgfbr1 Map3k8 Akt2 Prkcd Cdc25b Prkca Tgfb1 Ntrk2 Bdnf Nlk Akt3 Map3k2 Map3k1 Tmem97 Flna Map2k7 Mapk13 Map3k4 Tab2 Cd14 Mapk10 Ppp3ca Mapk8 Traf6 Map3k5 Cdc42 Map4k1 Fos Mef2c Nfkb2 Elk1 Elk4 Mapkapk2 Nfkb1 Egf Ngf Rela Fas CATECHOLAMINE SYNTHESIS%WIKIPATHWAYS_20260211%WP513%RATTUS NORVEGICUS Catecholamine synthesis Th Pah Ddc Dbh Pnmt RENIN ANGIOTENSIN SYSTEM%WIKIPATHWAYS_20260211%WP376%RATTUS NORVEGICUS Renin angiotensin system Ikbkg Pak6 Pak2 Pak5 Pak4 Jun Raf1 Rac1 Atf2 Agtr1a Prkcq Ptk2b Jak2 Map2k4 Map3k1 Itpr3 Itpr1 Pak1 Map2k7 Itpr2 Shc1 Pik3ca Mapk1 Mapk13 Ptk2 Mapk3 Mapk10 Agtr2 Grb2 Mapk8 Pak3 Stat3 Ptgir Fos Elk1 Plcb1 Mapk9 Ikbkb Ctsg Cpa3 Mme Ace Ace2 Ren Prkaca Rela Enpep Agt Ctsa Nln Cma1 Lnpep Anpep Mas1 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260211%WP1291%RATTUS NORVEGICUS Phase I biotransformations non P450 Ces2j Lipa Esd Pon3 Ces5a Pon1 Pon2 INSULIN SIGNALING%WIKIPATHWAYS_20260211%WP439%RATTUS NORVEGICUS Insulin signaling Map3k14 Socs1 Igf1r Irs2 Rps6ka2 Raf1 Rac1 Tsc2 Foxo3 Gyg1 Sgk1 Map2k6 Prkch Rac2 Inppl1 Slc2a1 Map2k4 Foxo1 Map2k2 Lipe Map3k6 Gab1 Gsk3a Pik3r1 Crk Map4k4 Map4k3 Pdpk1 Rps6kb2 Map4k2 Mtor Ptpn11 Shc1 Mapk1 Mapk3 Mapk4 Akt1 Rps6ka3 Pik3cg Rps6ka4 Grb2 Rapgef1 Pik3c2a Pik3c2g Mapk9 Ikbkb Map3k11 Map3k13 Pik3c3 Sos1 Shc2 Sos2 Cyth3 Mapk12 Grb14 Stxbp1 Stxbp2 Stxbp3 Stxbp4 Prkaa1 Eif4ebp1 Kif5b Cblc Shc3 Jun Insr Mapk14 Flot2 Flot1 Map4k5 Rab4a Xbp1 Kif3a Map2k1 Tbc1d4 Ehd1 Ehd2 Snap25 Arf1 Rhoj Hras Ptprf Cap1 Map3k7 Rrad Eif4e Inpp4a Ppp1r3a Map3k9 Vamp2 Rps6ka6 Mink1 Sgk3 Rps6ka5 Sgk2 Myo1c Map3k8 Rptor Enpp1 Ptpn1 Gys1 Stx4 Prkcq Gys2 Arhgap33 Rheb Gsk3b Map3k10 Prkci Mapk11 Akt2 Prkcd Tsc1 Prkca Trib3 Map3k3 Map3k2 Egr1 Map3k1 Prkcz Grb10 Cblb Map2k7 Rps6ka1 Slc2a4 Mapk13 Map3k4 Mapk10 Rps6kb1 Mapk8 Pik3cd Sh2b2 Map3k5 Prkcb Pten Map4k1 Reg1a Fos Elk1 Pik3r2 Prkaa2 Snap23 Pfkl SMALL LIGAND GPCRS%WIKIPATHWAYS_20260211%WP161%RATTUS NORVEGICUS Small ligand GPCRs Ptafr S1pr1 Ptger4 Ptger2 S1pr3 Ptger3 Ptger1 Cnr1 Cnr2 Mtnr1a Lpar1 Ptgdr Ptgir Ptgfr BIOSYNTHESIS OF ALDOSTERONE AND CORTISOL%WIKIPATHWAYS_20260211%WP508%RATTUS NORVEGICUS Biosynthesis of aldosterone and cortisol Hsd3b2 Cyp17a1 Cyp21a1 Cyp11b2 NUCLEAR FACTOR ERYTHROID DERIVED 2 LIKE 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP2376%RATTUS NORVEGICUS Nuclear factor erythroid derived 2 like 2 signaling pathway Acta2 Fmo1 Raf1 Akr1b10 Prkcg Mapk7 Actb Crebbp Map2k6 Slc2a1 Actg1 Scarb1 Pik3r1 Abcc1 Ldhb Fyn Pik3ca Mapk1 Mapk3 Nras Gstm5l Brca1 Gstm6 Gstm3 Rras2 Gstm2 Pik3c2b Gstt2 Pik3c2a Gstt1 Cdkn1a Tp53 Pik3c2g Actc1 Mapk9 Pik3c3 Sod3 Sod2 Sod1 Rras Nfe2l2 Hmox1 Eif2ak3 Abcc3 Jun Mapk14 Map2k1 Hras Map3k7 Prkcq Gsk3b Prkci Prkd3 Ube2k Prkcd Herpud1 Prkce Sqstm1 Prdx1 Abcc4 Prkca Acta1 Vcp Pmf1 Mafg Ubb Slc1a4 Mafk Actg2 Bach1 Dhcr7 Slc35b1 Akr7a3 Map3k1 Dnajc5 Aldh3a1 Xpo1 Akr7a2 Gsto2 Mgst2 Prkcz Cbr1 Pik3r5 Cdc34 Pik3r6 Dnajb4 Nqo2 Gstk1 Usp14 Fosl1 Ran Map2k7 Gstm5 Gstm4 Gstm1 Txn1 Mapk8 Pik3cd Prkcb Ftl1 Fth1 Ugdh Psmc6 Ephx1 Psmc5 G6pd Akr1a1 Psmc4 Gstp1 Pik3r2 Gsto1 Mgst3 Taldo1 Mgst1 Psmc2 Aldoa Pik3r3 Psmc3 Gclm Nqo1 Gss Gsr INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260211%WP74%RATTUS NORVEGICUS Integrin mediated cell adhesion Itgb3 Mapk12 Bcar1 Pak6 Pak2 Pak4 Shc3 Raf1 Map2k1 Itgam Rac1 Hras Itgb2 Mapk7 Mylk2 Map2k6 Akt2 Rac2 Rap1a Map2k2 Akt3 Crk Vcl Itgax Itgav Itgae Pdpk1 Itgal Pak1 Vav3 Cav1 Itgad Capn3 Itgb8 Vav2 Itgb6 Fyn Itga2b Shc1 Itgb4 Itgb5 Mapk1 Tln1 Ptk2 Vasp Mapk4 Itga8 Map2k3 Akt1 Itga6 Mapk10 Itga9 Itga3 Rapgef1 Grb2 Itga4 Pak3 Itga2 Dock1 Itga10 Itga1 Cdc42 Capn9 Rap1b Git2 Cav3 Arhgef7 Capn5 Cav2 Itgb1 Capn7 Capn6 Capn1 Capn2 Zyx Capns1 Rock2 Rock1 Rho Pik3r2 Ilk Pxn Braf Selenop Sos1 Src ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260211%WP4268%RATTUS NORVEGICUS Ethanol metabolism resulting in production of ROS by CYP2E1 Nfe2l2 Mafg Map2k1 Mapk8 Prkcb Cyp2e1 ONE CARBON METABOLISM%WIKIPATHWAYS_20260211%WP1292%RATTUS NORVEGICUS One carbon metabolism Mthfd1l Ahcy Folh1 Mtrr Dnmt3b Ftcd Dhfr Ahcyl2 Bhmt Tcn2 Dnmt3a Mthfd2 Aldh1l1 Shmt1 Gart Mtr Mat1a Mthfr APOPTOSIS%WIKIPATHWAYS_20260211%WP1290%RATTUS NORVEGICUS Apoptosis Dffb Ikbkg Igf1r Nfkbia Tnfrsf1a Igf2 Tradd Jun Traf2 Chuk Bid Tp73 Birc5 Tnfrsf1b Bcl2l11 Map2k4 Map3k1 Irf3 Pik3r1 Irf7 Irf5 Nfkbib Casp9 Bad Ripk1 Faslg Tnfrsf10b Akt1 Mapk10 Casp3 Irf4 Irf1 Irf2 Pmaip1 Bax Bak1 Tp53 Ikbkb Fadd Nfkb1 Prf1 Hells Traf1 Bcl2l2 Xiap Bnip3l Casp7 Rela Lta Irf6 Diablol1 Tnfrsf25 Casp2 Tp63 Fas Dffa FOCAL ADHESION%WIKIPATHWAYS_20260211%WP188%RATTUS NORVEGICUS Focal adhesion Tnr Col5a1 Arhgap5 Igf1r Itgb3 Reln Lama2 Egfr Lama3 Lama4 Col1a2 Thbs2 Thbs4 Col1a1 Blk Srms Txk Pdgfc Raf1 Chad Pdgfb Tesk2 Lama5 Col4a2 Vtn Tnk1 Ptk6 Col4a6 Ibsp Pelo Rac1 Lamc1 Actn1 Lamb1 Thbs1 Col11a1 Col11a2 Lamb3 Erbb2 Col6a2 Lamc3 Styk1 Pip5k1c Mapk7 Fgr Actb Mylk2 Map2k6 Rac2 Rap1a Map2k2 Actg1 Hck Pik3r1 Crk Vcl Pdpk1 Pak1 Bad Fyn Shc1 Pik3ca Mapk1 Ptk2 Mapk4 Akt1 Vwf Pik3cg Grb2 Rapgef1 Vegfd Vegfc Ccnd1 Pdgfrb Pdgfra Pdgfa Mapk9 Ilk Braf Mylk Selenop Sos1 Src Mapk12 Bcar1 Pak6 Pak2 Pak5 Pak4 Shc3 Jun Mapk14 Map2k1 Itgam Hras Itgb2 Gsk3b Akt2 Akt3 Col4a1 Pik3r5 Itgax Ccnd2 Itgav Itgae Itgal Cav1 Itgad Itgb8 Itgb6 Itga2b Itgb5 Spp1 Tln1 Vasp Itga8 Map2k3 Itga6 Itga9 Itga3 Mapk8 Itga4 Pak3 Pik3cd Itga10 Dock1 Cdc42 Rap1b Hgf Cav3 Diaph1 Tnk2 Pten Cav2 Itgb1 Met Capn1 Zyx Flt1 Rock2 Rock1 Elk1 Pik3r2 Kdr Pxn Pgf Vegfb Egf Igf1 Tnc Comp Ppp1r12a Tnn APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260211%WP487%RATTUS NORVEGICUS Apoptosis modulation by HSP70 Hspa1b Tnfrsf1a Casp9 Fadd Ripk1 Faslg Nfkb1 Mapk10 Casp7 Bid Casp3 Map3k1 Casp2 Cycs Fas Casp6 Aifm1 G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260211%WP73%RATTUS NORVEGICUS G protein signaling pathways Gna12 Gna13 Gnai1 Slc9a1 Gnai3 Gngt1 Gnb1 Hras Prkcg Rhoa Pde7b Pde7a Akap7 Akap3 Akap4 Akap1 Gnaz Prkcq Akap10 Akap11 Prkci Prkd3 Akap12 Akap9 Prkcd Akap13 Prkce Adcy1 Pde8a Pde8b Adcy8 Kcnj3 Prkca Pakap Gna14 Gnao1 Gnal Prkar1b Gng5 Gnaq Pde4c Gnas Pde1c Pde1a Gng11 Gnb2 Gnb3 Prkcz Gng12 Gng13 Itpr1 Plcb3 Ppp3cc Adcy3 Adcy4 Adcy2 Adcy7 Arhgef1 Adcy5 Adcy9 Ppp3ca Pde4b Prkacb Nras Prkcb Prkar1a Gng3 Akap8 Pde4d Gng8 Prkar2b Prkaca Rras ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP1302%RATTUS NORVEGICUS Estrogen metabolism Gstm1 Comt Cyp1b1 Nqo1 Sult1a1 Cyp1a1 Sult1e1 Arsl INTRACELLULAR TRAFFICKING OF CFTR%WIKIPATHWAYS_20260211%WP1486%RATTUS NORVEGICUS Intracellular trafficking of CFTR Cftr Nherf1 Fblim1 Ezr Rab7a Rab11a GLUCOCORTICOID EFFECT ON TARGET GENE EXPRESSION%WIKIPATHWAYS_20260211%WP1963%RATTUS NORVEGICUS Glucocorticoid effect on target gene expression Fkbp4 Pla2g4a Nfkbia Anxa1 Mt-co2 Tsc22d3 Nr3c1 Hspa4 Rras Nfkb1 ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP1299%RATTUS NORVEGICUS ErbB signaling pathway Crk Ereg Tgfa Nrg2 Nrg1 Areg Egfr Btc Nrg4 Nrg3 Eif4ebp1 Map2k7 Mtor Pak4 Cblc Jun Bad Mapk1 Ptk2 Plcg1 Stat5a Map2k1 Rps6kb1 Abl1 Grb2 Mapk8 Hbegf Hras Erbb2 Elk1 Cdkn1a Gsk3b Camk2a Prkca Egf Gab1 Akt3 Sos1 Shc2 Cdkn1b Src Pik3r5 GLUCURONIDATION%WIKIPATHWAYS_20260211%WP1276%RATTUS NORVEGICUS Glucuronidation Pgm1 Ugp2 Ugt2b7 Ugt2b1 Pgm5 Ugt2b35 Ugt2b34 Ugt2a1 Hk1 Pgm2 Ugdh CARDIOVASCULAR SIGNALING%WIKIPATHWAYS_20260211%WP590%RATTUS NORVEGICUS Cardiovascular signaling Col5a1 Stmn1 Thbs2 Col1a1 Hspb1 Vav2 Wnt2b Wasf1 Col4a2 Akt1 Vwf Mapk8 Vegfd Col11a1 Cfl1 Erbb2 Casp3 Arhgef7 Casp6 Capn6 Hspa1b Pdgfra Rras2 Map2k6 Pgf Egf Selenop Casp2 Tnc Col4a1 Wnt2 SELENIUM MICRONUTRIENT NETWORK %WIKIPATHWAYS_20260211%WP1310%RATTUS NORVEGICUS Selenium micronutrient network Cat Fads1 Fads2 Mt-co1 Gpx1 Selenok Mtr Kmo Selenop Tbxt Ptgds Gpx3 Alox5 Gpx6 Pnpo Mt-co2 Gsr Mthfr Sod1 Tbxas1 Ptgis Xdh IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP8%RATTUS NORVEGICUS IL 9 signaling pathway Socs3 Irs2 Jak3 Ptpn11 Shc1 Kat5 Il9 Vcp Mapk1 Jak1 Il9r Stat5a Mapk3 Il2rg Map2k1 Stat5b Akt1 Grb2 Stat3 Pik3r1 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP632%RATTUS NORVEGICUS Cholesterol metabolism Soat1 Hmgcr Lpl Srebf1 Apoe Fdps Idi1 Mvk Rusc1 Apoc2 Fdft1 Lss Dhcr7 Hmgcs1 Mvd Msmo1 Scarb1 Apoc1 IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP355%RATTUS NORVEGICUS IL 1 signaling pathway Map3k14 Nfkbia Nfkbib Ptpn11 Mapk1 Tollip Plcg1 Mapk3 Map2k1 Akt1 Mapk8 Chuk Traf6 Il1a Il1rap Map3k7 Peli1 Irak4 Il1r1 Irak3 Irak2 Capn1 Sirpa Tab1 Il1rn Capns1 Sqstm1 Il1r2 Il1b Nfkb1 Rela Elp1 Prkcz P53 SIGNAL PATHWAY%WIKIPATHWAYS_20260211%WP656%RATTUS NORVEGICUS p53 signal pathway Pmaip1 Ccnb3 Bax Gadd45g Ccne1 Gtse1 Cdk1 Bbc3 Parp1 Tp53 Rprm Casp9 Mdm2 Igf1 Bid Casp3 Igfbp3 Perp Fas}