S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation 298934 311844 305177 288912 295961 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III 294362 192172 24401 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) 24379 24380 ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II 25147 24299 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) 83512 171400 171142 84013 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI 307858 GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation 25014 308100 140547 364975 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis 25612 PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation 65183 113956 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II 313706 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism 282636 81677 83523 54260 171458 287533 365382 317576 85238 54259 316376 65038 308451 84018 499084 312952 309008 50557 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) 24962 24250 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis 24240 65156 313560 301622 619580 299976 191575 83782 85269 685679 58964 314004 361443 362720 298410 365320 29261 171566 288051 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis 64845 SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis 24311 24848 25120 317675 246281 ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis 89789 309262 29540 293688 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis 24763 353317 83512 65192 361637 171410 301120 25288 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II 309656 292016 313131 291534 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis 25290 29328 94199 81639 114097 287454 499689 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 291211 83791 89784 24450 81726 25014 29637 308100 25675 364764 310645 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation 192268 24398 L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation 29531 29383 360719 24813 NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation 24267 308868 29646 29539 29253 25750 310903 65183 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II 297393 302972 289608 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation 89833 299735 64300 29301 685999 NADH REPAIR%BIOCYC%PWY-6938 NADH repair 500983 295229 URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) 65135 81656 116593 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds 29322 25031 309855 24655 287745 24654 85243 366508 316457 140693 500709 114633 364298 497197 314641 50560 305482 114554 310463 497932 25738 116482 29337 59268 362490 363131 311355 81677 306808 497931 54260 116723 171458 192260 287533 89812 365382 361632 317576 289021 85238 116720 54259 65052 309419 65038 312634 308451 305419 84018 60664 499084 140607 688862 298947 50557 25513 29741 64161 313756 85240 81747 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation 29408 680409 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I 24439 294320 L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation 81670 307759 ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA 314800 296259 311569 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I 293589 308652 302642 360547 29473 L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis 24616 ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing 287425 311839 299566 287424 499174 60335 361812 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis 24240 65156 288051 GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation 497811 290029 83585 SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation 24787 24786 24248 25352 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis 282636 83523 290651 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) 64539 25488 26193 26194 26199 26201 26200 293448 301011 291103 690049 316632 293453 362344 301427 315167 362837 299643 296658 299310 252934 157074 681418 29445 689938 26192 293130 301458 314759 26195 294964 26198 297990 26204 361385 293991 94194 299954 363441 291660 691001 502592 289217 298596 363061 293652 690848 25282 81728 301123 497902 299739 289218 295923 293655 499529 362588 679739 300047 26202 26203 171335 303393 688386 286962 681024 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis 311847 288525 305291 298541 294400 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis 299976 191575 288259 311833 26956 81643 301005 362329 303179 315150 289276 117544 287420 314416 140946 24184 301115 29223 295088 83782 85269 685679 58964 362720 365320 171566 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) 499330 289095 298653 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt 24399 24379 81632 291133 24380 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) 290636 24377 UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) 498332 299195 366013 304542 29309 365592 25249 313706 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis 301005 362329 303179 299976 191575 295088 83782 85269 685679 58964 362720 365320 171566 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis 287379 293820 299857 58835 304429 288666 PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage 303179 79127 297389 83782 85269 685679 191575 58964 301115 171566 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) 396552 501907 65162 83783 25430 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation 25612 192268 24398 VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle 81716 24314 309004 399684 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I 24297 310848 24299 308445 29441 501907 83783 29296 246767 25426 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation 24165 290029 GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I 494500 24426 309465 171341 295037 289197 501110 24423 24421 64352 81869 297029 64570 81641 24422 24424 29487 25260 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 288259 64300 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis 25290 299732 29527 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I 298607 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II 310773 312828 360843 362713 29367 89841 CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) 298298 89789 64191 114100 170739 29580 81681 117278 29230 309262 29540 293688 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation 301622 83782 85269 685679 191575 58964 314004 298410 171566 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis 29328 81639 287454 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) 29416 287877 303272 361272 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) 500052 404783 367166 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis 308800 ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis 291969 297797 690441 116664 298103 140608 94271 685232 307923 117596 170667 171374 299971 297566 116550 94170 313510 299159 26197 65262 298451 245965 29757 171375 29754 192241 171082 303190 114630 300677 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation 287379 299857 64300 361472 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis 293820 58835 304429 288666 L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I 246307 246266 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I 306127 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis 117544 287420 288259 PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I 311864 499956 362638 304944 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis 291211 83791 89784 24450 81726 29637 25675 364764 310645 309262 29540 293688 89789 298298 64191 114100 170739 29580 81681 117278 29230 25014 308100 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III 24609 29215 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation 362638 289801 295620 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis 24450 25014 295458 117099 79238 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation 290277 78959 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis 116723 192260 89812 29322 25031 24655 287745 309419 24654 305419 140607 140693 114633 497197 64161 314641 313756 85240 81747 114554 310463 25738 29337 ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV 24248 29539 65183 314800 296259 311569 CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) 25086 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation 29711 25618 29592 64203 63864 29611 298942 25244 25014 308100 140547 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis 24792 83784 ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) 83512 361895 84575 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis 64828 25197 304023 305571 58924 288161 81919 25547 494342 313536 83505 303923 116740 63888 366064 171079 310508 64442 65196 363040 117523 25280 83626 24390 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I 116599 574523 79239 24451 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III 293620 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis 25197 304023 305571 25547 494342 313536 303923 116740 65196 363040 117523 83626 24390 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) 307848 310935 GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 291095 THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III 680668 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation 65135 81656 116593 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation 310378 CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation 291450 290551 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI 25368 PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis 29194 140544 84470 286936 362278 500368 293173 406165 310773 312828 360843 362713 29367 89841 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis 308800 L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) 64206 25721 311844 29416 59113 116682 171385 361272 685750 56823 681319 66029 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) 25147 24299 117182 25322 289456 29540 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) 24763 353317 83512 361637 171400 25288 361895 84575 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation 81805 HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis 24443 GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis 64828 25197 64442 65196 83505 25280 83626 171079 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide 58924 288161 296504 366064 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III 24192 296972 25086 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis 25331 171347 689330 PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation 84050 690610 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis 24240 65156 313560 619580 191575 83782 85269 685679 58964 314004 298410 171566 288051 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) 500709 306808 171458 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis 287379 299857 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis 192272 314304 681337 303671 246074 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis 171516 59103 192227 25527 29527 25526 58962 299194 24886 79242 29224 24693 311865 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation 287533 317576 85238 54259 65038 312634 84018 80849 309008 116699 50557 364298 305482 116482 362490 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis 191576 315851 84013 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) 287711 363069 RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis 25290 29328 366836 81639 287454 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) 310848 24299 308445 246767 25086 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis 59103 192227 25527 25526 58962 299194 24886 79242 24693 311865 366836 290623 291984 65210 286904 171522 266604 81639 114097 287454 499689 25290 29328 94199 299732 29527 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination 298595 29512 29511 54282 29520 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) 24616 PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II 293620 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis 81677 54260 171458 287533 365382 317576 85238 54259 65038 308451 84018 499084 50557 INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis 311355 306808 171458 50560 59268 688862 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism 29475 65162 25430 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway 58819 297437 50551 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis 25290 29527 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate 24159 KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis 690163 25014 295458 117099 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation 309147 289632 25375 298079 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation 25290 81639 287454 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine 81508 81522 365972 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation 24297 310848 24299 308445 29441 501907 29253 83783 29296 246767 25426 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA 171385 361272 685750 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions 29326 24404 29328 298376 116686 64317 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage 297508 289095 298653 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation 65029 81676 CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis 114101 313997 290843 362434 81925 29653 406165 305166 306582 316122 294324 296130 170919 296048 362702 311821 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt 296973 499084 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III 307855 85255 65183 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis 500983 296973 25634 24644 498731 316265 303565 24959 24333 25104 24551 81829 24191 292804 24362 25438 66020 24334 24189 24190 362282 114508 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I 29473 29539 29253 25750 65183 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) 64524 501157 362383 83688 VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II 679532 191576 84013 361895 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) 24763 353317 83512 65192 171400 361637 171410 84013 301120 25288 361895 84575 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 500709 171458 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle 362368 29739 291394 116684 25283 25458 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I 313560 619580 361443 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis 24385 24645 289632 25060 25059 25739 64035 24701 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation 29711 63938 81632 81708 29592 64203 29611 298942 25244 140547 301384 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) 362914 293526 360462 64370 295500 360811 24206 362228 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis 25290 29527 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis 306540 24401 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification 117260 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II 24385 24645 289632 25060 25059 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II 29253 TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II 690308 362855 84474 499866 312649 301374 292534 302247 289083 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage 79127 362638 291824 29261 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis 301622 83782 85269 299976 685679 191575 58964 361443 362720 365320 29261 171566 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis 361755 364064 287877 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification 494500 24426 24421 24422 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation 301005 362329 24165 312373 58813 313574 497811 290029 83585 L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis 24962 24250 25331 171347 29443 689330 L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle 298934 311844 305177 288912 25331 295961 171347 689330 84596 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation 282636 309008 83523 287533 365382 317576 85238 316376 65038 84018 312952 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation 25618 BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway 29373 50554 499508 29263 140590 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis 25290 94199 299732 291984 114097 499689 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis 360348 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis 24399 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II 25703 25056 497811 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis 29739 25283 25458 DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation 24267 29253 25750 65183 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis 366836 81639 287454 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I 306540 24401 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis 50555 83505 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I 24788 PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate 29634 500965 24534 PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III 302642 360547 29539 29253 25750 309147 25375 298079 65183 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis 29593 24265 24264 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) 64016 288364 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation 29711 367112 361215 29592 294972 64203 24513 29611 298942 25244 79238 361884 GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle 60666 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation 246307 290923 24401 246266 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation 501907 29539 29253 83783 310903 65183 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis 315150 289276 314416 24184 301115 29223 311833 26956 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis 302640 26759 170588 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II 24913 293711 288025 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 64206 59113 116682 56823 681319 66029 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis 246232 83472 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases 298579 361527 691905 287366 362039 29322 25031 24655 287745 24654 140693 114633 497197 310463 25738 29337 24913 293711 288025 691813 25096 25097 29526 690625 690388 296091 313756 85240 314075 691907 362792 289733 298581 192259 360426 29359 29692 24653 29354 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis 29580 29230 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis 24950 64677 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I 298298 89789 64191 114100 170739 29580 81681 117278 29230 309262 29540 293688 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis 29739 25283 25458 24401 COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis 287711 363069 294088 360511 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation 24191 24189 497756 24190 25659 498731 361730 PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis 298954 29562 24689 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage 79127 301622 362638 291824 191575 83782 85269 685679 58964 314004 298410 29261 171566 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis 29194 140544 286936 310773 29367 362866 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization 501907 83783 24311 24848 25120 317675 246281 29296 246767 25426 293504 24297 353255 310848 24299 308445 29441 25014 308100 140547 364975 65183 59113 116682 171385 685750 56823 289095 78959 681319 298653 66029 64206 29539 29253 25750 310903 361272 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) 50681 501072 65192 63864 252898 171410 25541 171142 301120 113965 79244 140547 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine 25750 24311 65183 78959 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging 316403 690654 293638 301544 301254 292759 116483 292028 290868 314442 292023 313047 266975 307492 306804 309596 313429 304919 306879 364070 289352 363172 685245 297969 294810 291556 297113 288917 308701 310672 293128 287191 287924 291624 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I 302972 289608 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis 24813 SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage 299976 191575 290029 24165 311833 26956 25368 301005 362329 303179 315150 289276 314416 24184 301115 29223 295088 83782 85269 685679 58964 292072 362720 24465 365320 171566 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) 58970 361213 296188 306351 360833 500651 366697 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP 290741 301622 299976 191575 83782 85269 685679 58964 361443 362720 365320 29261 171566 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis 313560 83782 619580 85269 685679 191575 58964 314004 298410 171566 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine 287379 245961 81508 299857 291450 290551 TCA CYCLE%BIOCYC%PWY66-398 TCA cycle 298596 363061 94173 24368 299201 170587 25179 157074 114597 361071 362404 79250 114096 360975 24551 81829 298942 289217 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis 360494 312706 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation 170465 65192 29740 171155 63864 171410 170670 25541 301120 113965 140547 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis 58970 361213 296188 306351 360833 500651 366697 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) 361895 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II 24172 24788 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis 25197 65196 58924 288161 83505 116740 83626 366064 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation 360816 TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling 29700 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis 84596 TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis 29498 29244 29270 L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) 59113 116682 171385 685750 56823 681319 66029 64206 25014 308100 140547 364975 361272 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation 26295 154968 CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis 317444 RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I 24188 297805 299511 266603 25703 25056 116676 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide 363040 295934 84597 81919 296504 494342 313536 117523 24390 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation 83782 85269 685679 191575 58964 314004 298410 171566 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation 65135 362638 81656 116593 289801 295620 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) 29475 65162 25430 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) 24763 353317 83512 361637 171400 25288 84575 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis 305571 286976 306860 494342 313536 24390 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) 29740 291075 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis 500983 296973 24385 65152 24644 25060 24651 498731 25059 60416 316265 25630 25741 24959 24333 24191 292804 25438 66020 24334 24189 24190 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) 24962 24250 HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis 25197 305571 58924 288161 286976 313536 303923 24528 24390 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation 301005 362329 58813 497811 290029 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I 361338 289219 304024 29421 MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle 308579 25413 117035 25756 25757 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis 89821 298182 290484 308800 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) 293453 289934 315173 498962 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation 29347 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) 290401 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis 310508 64442 65196 58924 288161 81919 63888 83626 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation 60576 24385 25060 25059 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis 65030 289440 25315 29277 366836 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) 24710 24711 266686 314264 293049 690953 362757 170635 89826 313689 64047 353252 25703 25056 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis 25146 360348 117182 171516 24950 64677 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis 301005 362329 303179 83782 85269 685679 191575 58964 295088 171566 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis 24710 266686 314264 690953 362757 170635 313689 64047 353252 24538 113902 25703 307660 25056 291955 114106 498940 25702 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis 25290 29328 366836 29527 171522 81639 287454 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis 497931 192260 89812 361632 289021 309855 116720 65052 309419 85243 305419 366508 60664 316457 298947 25513 29741 64161 314641 81747 114554 497932 116482 363131 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II 292804 24385 498272 114860 25060 363109 25059 289608 498486 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I 81632 291133 CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I 81718 24401 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis 192272 314304 681337 65192 171410 301120 84013 25288 26759 361895 171402 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation 81632 TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation 293949 25721 29408 361538 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation 286904 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) 83512 171400 84013 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis 81681 SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism 301543 301118 81536 114104 313339 192227 84431 170897 308589 65192 171410 301120 25288 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate 24165 289632 290029 PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation 362638 289801 315219 295620 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism 116723 29322 25031 24655 287745 24654 312634 140607 140693 114633 364298 497197 313756 85240 305482 310463 25738 29337 362490 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis 171516 24950 64677 291283 307092 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I 300886 287379 299699 299857 81522 64300 362657 361472 305248 680308 GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation 289481 79223 367146 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation 300741 L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation 25331 171347 29443 689330 ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III 24165 24465 290029 REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation 24787 29326 24404 24786 298376 24248 25352 113919 294744 259233 64317 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation 24165 312373 58813 313574 497811 290029 ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) 310848 24299 308445 296972 246767 25086 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis 287379 64040 64564 170898 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) 81677 306808 54260 171458 287533 365382 317576 85238 54259 65038 308451 84018 500709 LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis 25290 29328 81639 266604 287454 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation 50682 25330 362972 24254 361676 309207 24538 25702 363471 117554 291437 304289 24539 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) 311530 298071 312826 114711 CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis 303698 366196 29390 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation 24267 CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis 25257 81660 UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) 83472 GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis 83782 85269 299976 685679 191575 58964 362720 365320 171566 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis 502894 24638 24640 117276 54283 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis 291211 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) 299857 29261 ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis 83782 85269 299976 685679 191575 58964 362720 365320 171566 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 293504 353255 289095 298653 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I 313131 291534 DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis 29224 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I 314553 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) 83512 171400 84013 361895 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I 114860 TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) 25197 305571 363040 301155 286976 306860 494342 313536 117523 24390 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III 29539 65183 314800 296259 25086 311569 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II 29539 65183 314800 296259 311569 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation 29711 29611 24624 298942 301276 25244 293829 LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III 116569 316033 500961 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV 246247 310848 24299 308445 501907 574523 84493 246245 246767 54349 246248 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) 313843 298003 287835 24645 289632 114860 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II 297417 292804 360518 24385 498272 25060 363109 25059 498486 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis 81670 307759 INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis 315150 140946 81643 L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) 296925 29416 361272 291450 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis 266975 308993 291314 292759 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation 65192 85255 114209 65183 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis 291211 83791 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis 361300 WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis 304423 296098 499731 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I 29526 293711 288025 84050 296757 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation 25618 25014 308100 140547 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis 293504 64206 353255 59113 116682 56823 289095 681319 298653 66029 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation 65192 171410 301120 25288 114024 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) 25274 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis 305816 309207 24654 304289 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) 29171 84395 65054 29502 81826 288309 24778 293700 290029 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation 310848 24299 308445 361523 246767 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I 24645 289632 289827 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis 25290 299732 29527 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis 361755 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation 294103 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis 363145 292804 300741 300089 302915 501167 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) 298298 89789 64191 114100 170739 29580 81681 117278 29230 309262 29540 293688 UREA CYCLE%BIOCYC%PWY-4984 urea cycle 25698 59085 497840 25611 GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) 287379 245961 81508 299857 SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) 25274 81805 HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis 361338 289219 304024 25374 25748 25709 309070 29421 PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I 24624 301276 293829 L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation 29711 29611 298942 360816 25244 25044 GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage 24465 290029 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle 25698 59085 24599 24600 24598 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation 29443 81508 81522 24401 365972 29711 24962 24250 81805 29611 24624 298942 301276 25244 293829 25331 171347 689330 81718 TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis 25374 25748 25709 309070 MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway 89784 24450 81726 25014 29637 308100 25675 364764 310645 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II 25256 309732 ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) 114846 64045 DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis 313997 290843 362434 29653 406165 192270 314614 84497 64369 246115 252900 305166 363261 306582 309014 316122 295401 294324 300443 296130 170919 296048 362702 311821 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis 501601 D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 500709 171458 499084 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis 24311 25085 25699 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis 304423 499731 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I 25256 81718 60356 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I 292072 MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle 24551 81829 24401 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor 362738 25615 25729 290280 311412 24518 303614 114208 84471 171102 291464 24791 294515 305614 313121 25705 300947 116590 81809 50689 25717 29591 116554 81810 361831 641452 81920 24873 81649 85252 313588 296634 361415 170714 360643 360725 81647 290875 300054 361765 363088 313477 25406 311071 25281 84482 114495 59086 29610 25023 24681 24577 54245 24185 25388 24208 117273 303200 25389 680111 81758 29357 25631 25513 29741 25414 170538 25614 362817 314621 362675 24842 500695 84353 140926 170915 24890 79128 140670 161452 297893 287280 24468 362356 24516 56084 50554 300084 287069 94201 114483 114851 361389 83726 312916 297699 499508 292763 301535 54237 54244 685691 360820 314322 116651 24708 24356 58919 289752 302415 25639 362199 25318 308411 24790 295062 497672 308404 296558 305420 25735 500126 290744 316742 24517 24917 367100 81516 499497 64466 29508 25336 25337 191575 307799 314642 288671 304490 116551 315713 24666 117104 25521 29699 361109 25404 690516 367218 81762 313929 BDNF%IOB%BDNF BDNF 294515 116590 50689 25054 25738 116554 84027 50658 24703 25467 85385 314436 50646 679845 29376 24185 59109 CCR1%IOB%CCR1 CCR1 298400 57301 81736 309165 25542 116637 81780 287561 25124 301348 309242 83805 170538 25614 360820 116590 50689 81649 50646 LEPTIN%IOB%LEPTIN Leptin 50678 29340 25139 24329 117268 116590 24514 81504 50689 25125 29304 84584 83840 25622 25326 287659 296456 25608 81649 24790 24536 25513 29741 170538 25614 25467 29376 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin 25126 116590 24514 170851 50689 25125 85385 294515 361649 366455 361388 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor 24884 364420 307200 64030 500616 54241 25734 252971 24918 171081 361597 79113 81515 116590 116554 81649 54245 24185 81647 25513 29741 25023 25738 170915 84027 24703 85385 24516 309165 25124 83805 24514 81504 29304 83840 25622 25326 25126 287942 312477 116636 56718 54259 24336 311860 25150 25676 84427 81771 84357 500985 171136 24680 116680 363616 293621 305828 296072 305539 690987 294797 313845 297176 60450 60427 25094 84492 117538 CCR7%IOB%CCR7 CCR7 309165 56718 294515 287673 84482 24176 362506 298006 116590 29271 50689 25738 116554 84027 83840 81649 50646 24185 WNT%IOB%WNT Wnt 24884 313121 293992 24668 497961 298696 84426 116554 24672 25636 114554 312974 84402 310552 24881 114487 24185 24882 64566 25388 114850 317674 117273 79257 58868 64558 113927 282581 84382 364754 266608 309419 114107 170538 363062 679869 303181 50686 363875 25023 81679 24681 56011 84353 301334 29382 25671 84027 60328 83721 161452 303811 293897 314212 308796 295691 24516 25236 313589 24205 83502 170922 299858 312781 114483 293649 311658 362550 306782 58919 24680 FAS%IOB%FAS Fas 362788 301000 308937 25403 64314 114555 83584 361092 83507 56042 691947 362491 266610 81515 117279 25489 680915 83533 116590 83631 316810 50689 313128 116689 313050 207122 24185 360643 113927 170538 363875 140926 84027 58960 24224 24553 64204 81818 25402 25591 58918 306886 24471 25407 308061 287716 298652 296741 140657 58822 116549 81650 114214 64550 54318 300253 64045 63879 170851 246097 25385 362456 60661 24566 308870 29432 25150 56816 25676 25166 29355 79124 360748 64026 54287 288753 64044 24887 24888 89809 316164 64625 367786 501099 65189 311622 367901 24818 312510 81762 361655 311786 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin 24884 308015 294027 306871 117045 313633 24337 313017 114517 24185 25724 305506 24208 309368 117273 307582 140433 298941 25473 305078 117036 29357 192362 25631 29236 25513 300999 29741 29431 85243 170538 366508 25614 298947 64639 297383 362675 363875 29753 25576 56011 25578 60664 291926 114523 64315 25467 85385 29376 24553 83805 64204 81818 25402 24329 81504 25622 116636 56718 311860 25150 24680 NGF%IOB%NGF NGF 116590 170851 50689 81646 314850 84006 314436 360481 24790 HEDGEHOG%IOB%HEDGEHOG Hedgehog 89830 291936 29499 25273 25203 360715 309565 679693 25238 25255 299180 290284 301516 140589 304729 84399 293047 25636 25388 29753 84353 84380 361769 497991 246209 GM-CSF%IOB%GM-CSF GM-CSF 24884 25734 24918 171081 361597 81515 116590 50689 116689 116554 81649 24185 303200 25513 29741 25414 114495 64639 59086 50686 29610 25738 84027 50658 81646 24703 85385 314436 25124 58960 360820 114203 24514 81504 24699 25125 117269 25156 311030 83427 83840 498798 117287 309361 84351 64303 25493 64371 116630 361388 25155 25126 25416 294864 170851 287942 293721 29468 680611 24778 64159 54319 500985 24680 CCR9%IOB%CCR9 CCR9 83502 54319 307199 282832 311144 25713 81521 84482 315655 360750 54266 116590 50689 116554 84027 83840 81649 24185 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK 25126 170851 24918 58960 361597 29431 84427 25614 24600 116590 300955 290361 50689 89804 89806 367786 24703 85385 314436 81649 24185 CCR5%IOB%CCR5 CCR5 309165 116637 81780 287561 25124 24918 116590 29271 81504 50689 25125 116689 309361 84351 81649 25493 24185 25155 25513 117029 24177 29672 287562 29397 24770 24932 50646 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha 24653 85420 287398 362896 84598 29496 314384 25124 24918 301348 25125 29304 25156 83840 25493 54245 24185 300253 25126 287942 303200 116636 56718 170538 84482 500985 114495 25467 288774 498282 367264 29376 288264 TRAIL%IOB%TRAIL TRAIL 364420 81736 309165 64314 309295 246756 114212 64529 83805 117089 266610 500987 117279 78963 25402 313121 296953 25591 60430 83533 300711 116590 25341 306886 25309 50689 116502 83529 295238 246775 83477 65248 116549 81649 25493 24185 63879 25166 360748 500985 64026 288753 64044 24887 84353 64625 81646 311786 NOTCH%IOB%NOTCH Notch 116590 50689 29577 171046 54226 360801 114125 29146 25177 311567 289231 155437 311551 84010 84577 29147 170905 25631 315119 25496 29492 56761 406162 81526 363067 54281 311332 316626 500695 310405 292788 29192 170915 81751 25671 84027 313557 309626 294790 161452 362533 297893 24919 287280 300802 689844 362356 29419 362149 303101 50554 300084 81736 309165 24514 25125 M-CSF%IOB%M-CSF M-CSF 78965 307403 304063 317376 307248 366962 140694 65038 24918 266610 81818 306886 81504 25125 25622 24185 25126 54259 25513 170538 25614 500985 64044 85385 50646 25094 EGFR1%IOB%EGFR1 EGFR1 54245 24185 117273 303200 29357 25631 25513 29741 25414 170538 25614 362817 314621 24842 79128 140670 297893 24516 56084 499508 54237 360820 314322 24790 316742 25404 24518 116590 50689 116554 81649 84482 25023 24681 24577 25738 84027 50658 24703 85385 314436 50646 29376 81736 309165 25124 83805 24329 117268 24514 81504 25125 83840 25622 361388 25126 170851 287942 312477 116636 56718 311860 25150 25676 84427 81771 84357 500985 171136 24680 293621 313845 64030 54241 252971 24918 81515 29271 50686 363875 81679 56011 301334 29382 83502 58960 24224 24553 64204 81818 58918 306886 25407 79124 25489 116689 313050 207122 294027 306871 313633 24337 25724 29431 85243 366508 298947 64639 25578 60664 81646 314850 84006 25238 25255 117269 25156 311030 498798 64303 24600 300955 290361 288774 84598 29496 314384 65248 54226 311567 140694 65038 83614 24252 296654 85421 50557 29337 315305 24771 296603 83501 79249 116777 361370 65169 81732 289820 83617 303882 140908 64665 319110 303479 294981 306141 363599 360709 50685 295378 117542 24253 60383 308069 171492 84014 192277 503027 293619 361617 65046 83800 155696 25528 315707 360537 25308 311163 365657 312937 306506 308578 317335 500988 58948 309081 307562 29652 24799 306636 25313 366492 287986 304815 304786 60465 24333 60334 312279 316539 24338 287989 312812 313474 24186 24189 360842 60443 295053 116504 306204 83764 59265 309639 29579 315326 362938 192645 292699 300656 79209 315696 362156 117552 301333 259225 24392 304883 362046 296199 287710 498416 58844 83709 362342 296571 306400 315298 25176 117277 25380 56611 29424 192154 25462 64312 24954 360606 24511 64363 499747 79120 300242 25626 287702 294853 500965 299012 300438 288010 317598 116667 303604 308106 26198 25745 315840 291044 24211 29542 303259 313934 314961 116550 298744 302422 24629 64355 297911 81745 24161 289021 29525 25630 287925 25096 25097 117540 313729 29642 361677 498576 288908 360605 362860 363122 117541 310695 315970 78975 308444 25522 304282 29568 363855 501563 291356 81918 308959 303678 366275 24697 117255 25167 114767 360406 94202 192183 25739 361120 64633 116546 29622 83712 114488 81822 360857 64640 64205 83789 501560 81773 81778 502110 288663 25216 83841 362271 252855 302363 116743 81921 114613 29219 680309 114486 81803 57027 64678 64524 313494 301509 361517 305679 365548 191572 315686 140898 63836 291610 680511 680860 298694 304983 310838 362393 290467 316384 316369 304775 313994 292130 303517 315579 295625 296501 363425 58945 81634 298019 290834 312721 361598 114559 500989 291078 316101 685611 360871 360640 89829 312790 54133 308468 363466 689959 361724 500261 115769 207119 116673 291309 298875 315530 304546 64681 305178 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor 117254 362827 171068 25729 296078 361103 297994 288489 84509 29274 306764 171102 315179 361256 84574 114206 252924 50659 362862 25573 117064 680537 363247 117855 619385 64202 304157 289783 299313 117274 300772 25193 84389 293783 171103 84027 309165 83805 24329 25125 84584 83427 117287 24668 360801 24185 24208 25631 84382 25513 363067 84353 140926 170915 24890 297893 24468 24516 50554 83614 24252 296654 85421 50557 25402 25591 360820 24471 24708 58919 171150 362110 24790 83724 64550 192218 497672 286988 114562 303470 94194 64391 140610 24311 316742 29466 25690 303828 63839 116464 25166 293860 25019 689210 289508 64026 360552 85333 316123 64044 81674 361580 300193 140938 25098 60421 25617 299331 25205 25242 25404 302845 314856 367218 317259 288778 313929 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 140635 84477 81647 24918 24252 81515 500985 315305 171136 116590 50689 25125 81646 24516 24185 361388 CD40%IOB%CD40 CD40 170851 25513 25150 79113 81515 29337 116590 50689 25125 24577 313050 116554 50658 25326 309361 84351 81649 25493 24516 25155 24185 TNFSF3%IOB%TNFSF3 TNFSF3 362788 81736 309452 309165 25625 156767 25008 297604 361795 25493 24516 311786 ID%IOB%ID ID 25389 680111 304786 81758 25631 362871 25261 25587 25585 291023 362817 299766 679869 337868 83499 24708 29577 171046 314436 G-CSF%IOB%G-CSF G-CSF 84598 25734 25124 24918 89829 81515 116590 24514 81504 50689 25125 313050 25622 58822 81649 24185 25155 25126 84477 54259 81771 500985 362817 83571 83681 25610 298518 25319 246144 29526 305584 24786 24804 85385 84006 113975 EPO%IOB%EPO EPO 314384 24918 58960 294515 116590 114203 24514 50689 25125 25156 302415 25622 114486 24185 361388 25155 25126 170851 287942 56718 24336 84482 64639 24600 50686 24703 288077 29517 306969 24516 29376 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma 24653 292060 85420 116465 24508 362896 290749 689314 84598 366126 25124 24918 29337 24329 116590 24514 50689 25125 116554 81649 54245 24185 287942 24253 500985 24703 368057 TNFSF1%IOB%TNFSF1 TNFSF1 362788 81736 309452 309165 25625 156767 25008 366518 297604 309295 25493 24516 24185 TNFALPHA%IOB%TNFALPHA TNFalpha 362788 64314 266610 117279 313121 50659 25573 116590 50689 116554 641452 81920 81649 309452 25625 156767 361765 114495 29753 25576 25578 50658 305584 81646 81736 309165 353256 60371 25124 301252 116667 84020 303604 85245 83805 361055 307449 291885 24329 288532 309168 305606 81525 316241 58934 685607 498109 83427 83840 681193 25622 171121 29425 309361 117263 84351 25581 29677 25493 83806 287984 287670 25155 361388 307821 287772 365388 246273 312477 361711 680611 64302 499374 81774 684988 301515 304005 316051 313245 171379 361825 301020 685179 303518 25522 24835 311245 29568 56010 293960 305451 408217 83582 360491 353233 140934 287367 361925 314756 498206 315291 360600 308761 115771 289014 310877 25069 314384 309295 304893 246756 361167 24918 301246 303285 64640 363984 266764 289924 305240 114089 252961 84581 313867 303602 116633 314417 246240 116596 499069 25233 292747 312641 301225 29372 361810 24185 308267 303024 362607 25586 83581 362247 84577 113900 316033 29476 287707 305751 299827 170538 56011 60328 297893 287280 362356 24516 312916 360640 25402 54244 306886 24471 24708 140657 116549 362110 114562 140610 171492 293860 29355 64026 64044 315713 64625 299331 317335 25404 311786 GDNF%IOB%GDNF GDNF 170851 312477 25150 58960 24553 24716 25414 25085 307511 54237 25614 501560 360820 83840 24703 50646 25493 54245 24516 361388 TNFSF8%IOB%TNFSF8 TNFSF8 362788 116590 81736 309452 309165 680611 25069 305584 24185 CXCR4%IOB%CXCR4 CXCR4 294515 81515 116590 29271 50689 116689 313050 54245 25388 117273 303200 25513 29741 25414 170538 25614 303634 25149 64639 499537 25686 363875 59076 25464 56011 309684 363577 25738 155918 84027 65172 81646 84348 24772 116592 25361 314436 60628 50646 24468 291796 81736 309165 25124 58960 301348 83805 29337 315305 24329 24771 360820 296603 24514 24699 25125 117269 29304 25156 83840 25622 25326 309361 84351 25493 25126 170851 287942 312477 54259 25150 25676 500985 171136 300955 117029 288774 367264 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway 24516 64152 311658 314322 94165 116630 25704 116562 25712 25385 140666 84349 60462 171068 25445 171026 25639 24517 287287 25636 29527 361400 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling 24516 367846 81646 170915 81516 363067 85471 94201 117036 362817 681373 24577 24468 24413 24790 313929 361109 83712 680111 83724 300054 294515 499497 84482 25164 316742 25735 296500 317715 24497 114851 24208 54244 81647 337868 24185 24370 114208 24873 24890 114109 84577 297893 116651 313588 171046 24481 84352 360743 362827 60661 302415 303539 24617 29357 25631 50554 290284 24253 317376 313666 685491 367218 50662 29382 25389 156726 25325 361391 293624 64466 83614 314322 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events 29197 301289 301291 81736 25493 25124 24835 303413 367264 25125 689932 681145 89829 170819 24514 301365 155140 24494 360606 287562 24599 315609 246759 25513 309165 64546 287425 24498 24932 171551 24918 116562 25712 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression 300772 85252 363287 25573 297893 84509 83422 314856 294429 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events 24516 116667 25619 81687 296654 81736 25493 25513 309165 314322 25414 25155 25353 360640 170922 295378 116554 363875 116590 25537 50689 50646 117273 25406 309361 296456 81686 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events 81810 81516 81650 59328 59086 85435 79558 29263 25404 25366 140590 25237 25671 24668 25261 680117 290921 29200 25388 25717 29591 116590 50554 50689 25639 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase 24516 81646 300955 25622 313845 286908 293621 25453 498416 84427 25513 312477 81504 498898 54245 59312 24680 24716 361388 29376 85385 314850 360820 295347 25454 361364 25414 25676 25467 83805 25614 116554 363875 116590 50689 117273 25636 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events 170582 24553 81687 363265 290905 84032 25412 170583 59086 64537 29393 64367 140433 83841 25114 84489 361821 84352 25216 294337 85250 25246 116590 294279 25654 50689 85490 363457 300339 25335 25636 24446 29647 81780 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation 29340 192117 24605 83781 313874 360797 24592 25023 361714 24245 56646 313845 207119 25522 293621 170668 114633 192126 361568 360814 81504 29434 25597 114513 24525 24680 25676 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling 114592 292554 293733 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events 81649 288135 25651 366126 114090 25601 171075 25563 500616 24832 29221 399679 25126 500985 24790 303903 362896 24497 81504 24185 29376 85385 84352 25467 24253 25325 29393 89829 24514 25513 24918 252971 83840 29397 140924 84598 25326 24888 117062 171060 252963 25008 116689 54259 84349 297783 117518 361597 81639 25084 24356 56718 287287 303836 25046 290361 291100 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K 81736 24577 299331 29304 308909 24224 313050 292148 294515 301965 83626 353229 25622 84477 313845 399489 25522 25513 309165 81504 24185 85385 83840 140924 84598 25326 24888 25704 116562 363875 56718 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling 313050 25622 84477 313845 306400 293621 25718 24482 316213 24600 310738 81504 89804 24628 362051 25205 24499 89807 361388 83785 25686 85385 116465 314850 25313 81737 25730 24629 26955 24329 25467 25615 24703 59109 25054 29613 25643 24225 170851 58960 25124 24605 24514 25513 24498 24525 140924 84598 25326 25704 116562 25712 117273 25636 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network 85489 29382 25591 83571 155430 170915 25496 25242 64186 24919 24708 362533 29577 117034 25235 500569 367562 313929 25172 316626 25125 25295 155437 689844 60329 24514 399489 24208 54244 337868 24932 297893 171046 291787 29300 24246 54254 29560 303101 367218 360801 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions 25724 25118 311061 170921 25713 364786 499271 310683 24511 309684 685004 64350 308995 25021 685269 362800 360606 311144 114517 315346 81008 296456 315744 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events 307511 296137 314642 361765 84391 361308 24672 117281 116646 29431 56082 311529 308761 306464 303024 301701 54237 29648 306102 171576 293733 25594 25515 311502 317252 116670 261730 308937 81754 361195 298534 362044 311546 252921 64528 25203 25537 292263 64515 363174 117273 313304 171103 363028 361921 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events 362817 81920 363247 312641 24361 361435 289752 305600 300711 25019 497672 311670 691105 25729 64012 360748 64046 363836 25737 85482 24842 315969 499155 64557 685055 309643 499870 291787 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway 81663 50664 81664 25643 25686 117273 25740 60399 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma 29753 25578 81646 25576 81745 84027 24605 294515 313845 293621 25513 310738 81504 24185 24525 24918 361388 85385 83805 59109 313017 59317 56011 170538 60395 83810 64639 58919 25738 25050 24330 25400 56010 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 24516 294270 294269 59086 303496 29197 25710 300678 24508 25300 50669 116553 303828 25660 367264 25408 25125 56822 50658 301365 315609 54244 24932 83422 314322 25704 116562 25712 116554 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling 296137 361308 301701 64556 301555 295107 29670 362519 300266 500545 293507 315298 298850 64362 306562 362438 171529 305392 25498 81818 29542 114592 680089 292554 313445 293733 315740 29332 24669 361191 363193 288057 313348 261730 25676 363174 117273 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events 29431 300955 25513 114523 25414 310178 306722 83805 25311 25614 309081 60630 25150 24884 363875 60629 116590 170851 29525 58960 29456 50689 362049 361251 117273 25738 310192 25400 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway 25686 25740 60399 81663 50664 81664 25643 116590 50689 117273 25738 314649 303634 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events 497932 116590 170851 298947 29516 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network 24649 308267 170915 366126 307829 24165 363067 361370 85471 305081 29728 361745 60427 501403 24577 680006 24468 114483 26296 24790 54267 24424 64635 83800 295953 24224 361205 314615 310218 83584 171347 313121 25714 25163 161452 293621 304063 501204 114851 81641 362342 54244 29598 78971 337868 307403 64030 29316 116462 58940 299606 295052 116698 497961 361598 245959 299810 24674 84352 24252 24881 24253 58919 83571 83614 29577 303413 25172 24605 24525 24932 25573 25203 24356 29527 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling 29431 24605 300955 293621 84427 361568 25513 81504 54245 24525 85385 360820 295347 25676 287989 83805 313633 25614 24338 24825 85238 140694 363875 171337 116590 170851 360546 306636 50689 25186 116683 29491 84009 81762 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway 89809 116667 81649 367901 246097 54241 81745 64625 25402 54319 84351 246274 85243 114495 363855 64044 309295 306886 689314 60371 25272 308909 50658 117279 25513 78971 24185 25155 83805 25385 116554 309361 266610 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events 310344 83722 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway 116667 64625 24708 81736 24577 25493 64044 24835 306886 308909 24224 308589 246756 311786 311130 54287 360573 25522 25625 64513 24482 361167 25266 94193 502531 309165 78971 83533 24887 24185 94338 353233 84431 287398 171293 25309 314756 25313 24703 116554 170538 116590 170851 58960 50689 64639 266610 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling 313050 363836 59075 25085 363193 85240 81515 29245 25734 56816 25155 364403 83805 266606 307309 117287 25150 29545 24884 170538 24898 116549 79113 64639 29219 25639 50646 25096 25097 25750 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway 81649 309165 361765 84351 81736 25493 25155 83805 313050 25388 680611 305584 25513 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway 29355 24516 207122 83571 116743 690538 29636 309419 54319 501099 305679 24782 307799 114495 29437 60352 313494 29271 83476 315151 50557 314641 315655 81521 307483 363925 65172 83620 29524 303200 25522 81647 287398 24511 314322 116670 116554 25537 25096 117273 25097 81762 24784 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B 25404 25126 313050 78965 114246 24697 29173 315707 116591 312477 29153 81504 85431 24628 307403 24684 24185 54245 306141 24506 25608 24536 81511 24683 85385 301737 25313 116484 24954 83501 24629 500538 24329 25467 83805 25125 89829 24514 685269 25513 24918 81515 25414 25734 364403 25150 24884 79113 117273 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events 170582 25402 54319 170583 59086 83841 25114 84489 24592 293621 24887 170921 24511 25087 25661 116630 25676 367073 25615 307582 83805 313633 691719 313052 316758 116554 363425 170538 83427 116590 50689 117273 25636 29647 81686 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway 24525 24680 314322 24605 24703 25023 116590 116596 170851 114486 50689 314436 246781 293621 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network 24516 81649 25619 81646 170915 94201 29221 24224 497672 81647 24506 24680 24890 58919 116589 81809 292907 361679 83516 63995 25267 25389 29384 25544 24518 361391 116674 29317 94164 24708 117271 114494 499723 29577 192218 114856 171109 29467 689314 25112 50658 89829 301555 24592 155140 24599 24498 25085 314322 24888 25712 116554 171068 116590 50689 24517 81686 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling 497932 500985 287418 140908 287942 60589 313050 29202 296603 171287 316539 29210 312279 84358 94268 246217 366492 170901 54245 81515 25734 364403 83805 295378 25150 24884 79113 116683 117273 25738 298947 81762 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I 170915 361765 81516 363067 83712 54244 84577 297893 60661 290284 685491 360801 24919 81736 25493 24835 25172 25125 25625 306840 304539 309165 25159 364382 84582 84581 361724 299104 293615 85252 690516 363287 310769 25573 309757 84509 303241 297453 25664 294429 680172 117535 361532 252924 362981 681012 363481 299638 290669 362391 84578 310614 362834 25636 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events 117028 24176 25108 54241 84353 302983 83502 81757 50556 171041 25360 307505 79121 24180 311163 171455 25751 65168 314641 191575 60627 25139 252881 685004 360606 311144 114517 315346 81008 315744 25118 170921 24506 364786 310683 24511 25096 287443 25097 362719 64632 360600 296456 29528 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling 29753 25578 83571 25576 170915 84353 81757 84351 362817 25112 25272 50658 294515 113927 294790 84482 64086 116546 81758 24248 29517 24787 24566 360471 25634 54244 293960 171043 64547 24185 64823 65278 58822 64462 85252 309757 84509 25515 313017 25385 302415 56011 116554 25203 303836 309361 56010 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway 309242 24565 25686 81536 29415 81662 81666 286896 170897 25740 306792 60399 29733 81663 89788 50664 81664 308589 25643 314649 303634 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt 29753 25578 83571 25576 81745 84027 299331 25139 294515 84482 114851 360748 24185 24888 83805 24703 310131 313017 288064 302415 64226 56011 50686 58918 29414 296648 25233 64639 56718 25636 309361 56010 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction 304920 81679 60465 84353 58823 79249 83502 307505 79121 311163 314641 191575 296603 25513 24185 54245 25713 361598 295347 26955 83805 363875 171337 292994 58919 360891 117273 306332 25252 313024 304109 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family 24185 50938 116565 291936 360715 29216 313506 84399 25273 25238 29499 24695 84380 304729 89830 25388 81809 25513 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle 310344 58936 83722 25515 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway 24516 116667 81649 84353 309419 83502 29431 307505 29271 314641 65172 303200 81647 54245 361598 313024 58823 79249 114495 363855 25125 50658 297518 360854 309168 54227 288669 289820 81732 315298 299012 29432 66021 311793 360678 79129 117542 679934 364018 301511 294568 287398 286928 24918 302976 114553 310621 85240 25414 116554 363875 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones 365901 85257 84550 116556 499132 60449 314264 500418 114248 83579 171107 316218 301233 81760 89826 29481 64047 361752 690825 79222 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity 310838 114559 84014 314904 309362 311193 117020 363460 313934 363509 316639 317598 305938 367039 83709 313438 24205 191575 296603 315298 246217 360678 295378 25738 29491 63994 66013 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network 85489 170915 25242 24790 54251 81707 64525 367176 24644 54702 308457 308913 24778 312382 79116 94268 24874 299872 79431 294562 114490 54244 25715 24335 29452 499335 309434 25369 83785 309757 24617 314436 24356 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity 24516 81649 29355 170915 361745 24413 313929 299331 83724 84482 24208 54244 301020 58850 289783 303470 297893 363026 500084 191569 689210 25271 24252 83574 361801 83805 300193 50659 303396 303518 156435 83427 303480 361798 289508 65028 24330 84027 114495 192218 25159 84582 287398 309757 314856 252924 116554 171068 305584 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway 24516 81504 25267 54245 501099 85385 25404 84598 314322 287942 116549 314436 313845 362205 25738 29161 296456 25513 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events 25582 170582 25635 292788 60465 58982 289231 24924 300802 170583 25114 84489 24329 83805 25150 116673 24664 29647 29192 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta 24516 81649 81646 83586 315305 24782 315994 64633 27080 498183 24653 29467 289014 689314 24471 304786 25183 500526 116636 25626 117045 499497 25094 304962 314384 24599 81647 24890 24842 24253 29527 83516 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events 25578 79249 79121 313494 83709 60350 619374 81517 311144 25621 691644 315610 292406 25521 25361 304979 54245 25167 293508 290344 24511 360820 25661 25414 25353 83805 25614 309081 363875 50646 25636 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network 287102 114107 317674 313589 306782 302526 293897 312781 58868 24882 64558 24881 303181 293649 114487 64566 364754 282836 315196 266608 114850 282581 114557 64512 360622 140585 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network 679869 24516 64188 25619 299757 81646 81687 312916 170915 84353 308411 24323 114485 59086 85424 297994 79451 29437 689415 24577 25312 116510 24413 29237 24790 54267 83476 24179 24392 54237 50557 25163 24497 81647 64547 24890 24842 84352 58919 300339 29560 24330 25389 83571 25325 24518 361391 114856 287562 25159 24498 25085 311658 314322 116630 116562 25712 25445 24356 24517 287287 24602 361400 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events 24649 81504 24918 83841 25126 81515 83681 114103 171081 24514 25622 24497 25513 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling 24516 25591 114559 81646 84353 84027 363509 299331 689069 301509 307483 114562 171010 308875 362271 259225 362973 57341 304546 296313 288770 65137 114636 316369 311191 24185 360962 114004 64538 361303 25705 85252 116490 81634 360820 361598 116670 261730 310131 170922 363875 58919 292907 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events 81679 60465 84353 296654 307505 311163 24392 314641 363925 25622 24697 25513 301737 79257 29627 117550 83501 29167 171140 304289 79114 25248 293649 29423 114764 309207 116554 363875 117273 25738 81762 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor 24705 60351 58851 59086 24835 313929 24224 24873 83840 25664 25271 83574 361801 58852 78968 313210 25682 497991 308218 24831 81812 25747 79240 360801 685072 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network 246334 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network 24516 170915 24577 313929 83724 497672 362051 25737 24890 58850 24683 297893 50554 497991 24253 58919 360801 287164 252891 114503 171355 24232 289754 64520 117553 64441 29663 25490 29722 94271 64539 171119 302973 117274 299864 24561 25154 29134 361509 64196 85251 360815 24786 83628 498995 304157 25379 84584 25149 304054 117270 246047 24918 171293 365462 114766 363287 307947 309361 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling 81649 85424 29431 25126 24180 84482 300955 25622 114851 84427 24600 81504 89804 24185 54245 89807 85385 360820 25661 25676 25614 314436 81736 24835 315346 25513 309165 24918 24511 83840 85253 29251 89805 296269 305451 361944 58844 54250 367786 25150 116554 363875 116590 361597 50689 24356 25097 290361 81686 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells 24516 25710 300678 25300 50669 24835 29340 367264 24605 50658 25023 293621 315609 24525 24680 140924 311658 314322 25704 116562 24703 25712 25129 25385 500598 116554 25572 500590 116590 502962 170851 114486 25445 58960 502959 314436 50689 24223 246781 85420 24517 24930 24931 24330 288264 316052 361400 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase 78966 24516 361882 114559 314961 171070 29154 302983 305679 29431 29437 313494 300955 313845 306400 304546 84427 316369 81504 54245 81634 360820 295347 25676 83805 24703 25614 171337 170851 114486 58919 25738 50658 315346 361568 25513 287398 24511 25414 309081 367786 25150 116554 24884 363875 116590 25537 24356 361251 117273 296456 307459 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions 25724 307582 316758 305078 192362 309368 117036 298941 25473 140433 114517 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway 361765 116468 29577 310034 288414 498411 360847 303024 360254 301014 500987 140583 360588 309256 294800 312641 502320 24361 313387 361435 501552 303742 305600 308755 300711 363164 287524 497672 288003 304528 691105 293452 59102 64012 306734 64046 85482 315969 499155 685055 309643 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms 246334 24165 25496 84027 29577 27080 360254 25163 360606 300711 117058 292301 64046 24493 311567 24873 29326 25245 287701 312754 25431 297930 83521 24484 314856 116486 112400 303443 312451 500023 313017 252916 308444 65138 292949 83427 360243 294071 85490 363088 50662 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis 116667 296654 29437 24224 83584 65172 78971 25614 58918 78968 54226 362456 308870 64159 499156 293625 316164 25591 78963 25166 64314 64625 294853 25402 114555 288753 366624 64026 54308 306862 299625 50669 64044 63879 84359 24835 306886 114214 60374 60371 116685 64550 246756 311786 25625 94193 24887 81818 25309 314756 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity 114559 84014 314904 79249 311193 363509 317598 305938 367039 362893 287537 310635 296603 311647 312912 360509 309696 310909 313845 309642 315298 312812 246217 25156 360678 114513 309081 295378 363875 361251 310192 84009 63994 304109 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling 25619 81687 25651 24832 81736 313494 24835 25021 619374 691644 25464 24566 81722 54225 363930 300999 64032 315509 24498 680054 25692 299858 309684 85253 295347 25734 171337 117273 81762 81686 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway 81830 64310 303002 79121 191575 363875 116590 50689 25096 117273 25097 84009 304109 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells 24516 116667 500985 25622 84477 313845 293621 312477 81504 24185 81511 85385 301737 360820 170897 25676 29733 24703 25614 170851 58960 25738 367901 84351 81736 363855 114856 309295 24653 25023 29432 25156 25513 309165 287398 64369 498331 311658 58975 314322 117538 81515 317676 25316 25047 25155 155918 288077 29526 289211 54259 25150 171136 116554 363577 116590 50689 25097 309361 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway 54251 24514 24628 24185 309242 83785 25686 81662 81666 24629 25740 306792 81663 89788 83805 50664 81664 25643 363875 60628 29414 116590 50689 117273 303634 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling 25361 25614 25713 54266 24511 117273 360820 311144 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling 60450 140930 114858 311860 291713 499652 83823 117020 192204 360481 59293 113894 308875 25622 84477 313845 293621 316213 310738 81504 54245 361388 85385 314850 81737 295347 25730 25676 59109 25054 29613 140694 24225 171337 170851 58919 25738 304109 24605 25125 287942 25522 25513 24525 309081 363875 116590 84006 50689 83462 361251 84469 117273 315530 291553 24596 314612 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events 497932 367901 81745 85243 79121 116691 116693 116692 499356 29337 299331 50557 301348 24605 65038 79117 361659 313050 171097 294515 362046 29517 293621 25513 24525 81511 64310 295347 81515 25734 25155 364403 83805 54259 25150 24884 363577 363875 79113 117273 25738 298947 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events 308267 85243 25126 59325 24514 498596 292041 25433 24410 57027 59323 24337 64022 25513 29495 361431 81504 690919 24684 25489 432361 312574 311567 24918 24683 85385 297930 314856 112400 25150 116590 50689 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events 24649 25578 84351 25126 25124 83681 24605 25125 171081 24514 25622 84477 313845 287562 293621 25513 81504 293508 24525 292060 289747 24918 85385 81515 314322 116630 25155 24703 54259 116590 170851 58960 50689 25636 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta 29355 362242 29513 29332 303200 25435 58919 114495 60352 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction 24553 84353 58823 79249 83502 305679 307505 79121 311163 83709 314641 307483 252881 363925 300955 94268 25718 24482 366492 114636 81634 308417 25313 288010 29582 315840 65133 26955 25241 24329 300228 81803 361517 307644 360891 117273 24446 81762 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 81649 84353 305679 307505 25404 500985 303024 25751 299331 54251 300955 25622 303200 498416 24600 316369 81504 25489 24185 24680 361388 83785 360820 361598 83805 24703 25614 56084 29645 170538 301252 29169 170851 114486 310688 58960 114124 309499 117063 25738 83506 307618 81762 81745 114495 289014 689314 25023 29432 25513 64310 116689 25150 116590 361597 50689 50646 117273 25636 296456 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation 24649 81687 170915 94201 24577 299331 191575 301965 24778 65137 54244 85482 24842 116490 60661 303539 25631 50554 292907 24240 287379 170910 171102 287436 64371 116459 373541 63868 29653 500983 287986 64520 307151 192218 494345 25574 362631 689054 64033 500965 291105 266670 64556 313905 500448 117045 64831 308490 64678 361894 65152 24333 25587 54318 306012 292264 29592 83782 24609 25498 24887 361925 266759 288471 117062 25445 25203 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta 63995 81649 81757 29431 114495 114856 306886 689314 313050 116546 303200 29432 29433 311245 287398 25579 297682 303604 81515 25734 364403 83805 25150 24884 363875 79113 361679 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) 60450 60427 500985 50557 24224 294515 25622 313845 293621 498416 54244 312477 81504 24335 24185 64030 361388 85385 301737 24703 170851 58960 64639 81745 84027 25124 25125 287942 25094 24514 25156 25513 24918 252971 83840 292763 84492 289021 366962 81515 296072 305539 305269 114203 24336 50677 116689 116554 50689 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network 89830 50658 25296 54281 116554 29348 25236 29499 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events 499285 25361 293589 360457 83785 24511 360820 25661 116630 25414 25353 83805 685004 363875 57025 114111 679837 302642 170847 24599 60327 56083 56806 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining 360748 259171 290907 308576 294051 289757 500247 363251 259271 361767 309995 363247 25019 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) 24516 116667 116743 84353 29636 83502 29431 307799 307505 79121 29419 500985 24917 292756 303886 24205 65038 84357 301334 311494 287871 313474 292887 361396 300955 25622 84477 313845 293621 24697 316369 81504 24185 54245 361388 116490 85385 360820 295347 83805 24703 25614 64226 56084 29645 171337 170851 58960 25233 64639 117063 25738 24446 24330 24553 81745 64633 287942 116636 117045 25522 29432 25513 287398 25414 54259 116554 363875 116590 84006 50689 24356 117273 56718 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway 296654 85243 29431 313494 25124 24605 25125 314641 300955 25622 313845 293621 24697 25513 81504 316369 24525 361388 25686 85385 25313 25676 24329 83805 25614 116689 25643 116590 50689 25738 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events 29355 29636 25751 363925 25023 24681 89823 25439 25372 29322 291464 60323 84471 24600 25513 360678 24400 114636 24654 25387 24680 309242 25686 81662 29251 85240 81666 25740 81663 89788 50664 361517 81664 25643 170538 140694 25537 117273 303634 81762 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events 81687 83823 83841 25751 81517 315346 170700 29436 24680 24771 24772 497867 24511 81634 85253 29251 25661 79114 307582 54250 691719 25614 316758 170538 363875 60628 679837 117273 81780 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway 81649 311860 170915 24672 362817 140583 113927 294790 64086 25163 300711 360471 362342 54244 24185 64823 65278 58822 64462 24842 361831 29282 116698 298696 363140 685055 287585 301674 689820 140926 501206 304798 305837 681359 362273 310194 170538 289372 114212 314862 289508 689954 25405 362102 84027 24919 114494 192218 362631 25490 50658 364382 314856 116554 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes 24516 315911 140866 317382 114090 25402 85471 303496 94201 24835 54267 399489 24697 24497 311567 311658 25664 314322 116630 25704 116562 25712 25129 25385 84349 171136 60462 171068 25445 85420 24517 287287 50567 63835 24330 29527 304267 361400 291100 25148 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events 81679 84353 83502 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway 81649 24516 309242 25686 29431 29415 81662 81666 314322 25740 81663 25467 89788 50664 81664 25643 116554 363875 116590 50689 314436 117273 303634 307618 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling 81646 25194 360552 24775 29337 293621 29322 25513 24208 24400 24654 24185 25686 85240 314322 25740 83805 24703 50664 25614 81664 25643 363875 116590 170851 58960 50689 25738 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events 307511 25729 58936 24842 114212 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 24516 25619 81687 170915 24518 25333 114485 24451 29139 302680 114494 60584 688954 83580 81817 79255 24790 24392 25295 25163 287562 24600 25724 24498 311658 84352 307582 25445 58919 24517 300339 361400 81686 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway 29382 307511 171102 311860 259171 64625 310034 192218 309995 29486 290997 289468 500987 63996 116725 296099 361403 312641 308755 300711 497672 64012 64046 85482 116698 314856 56011 114212 291787 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha 78963 246097 64314 64625 25402 64026 81736 25300 363855 25493 64044 24835 306886 117279 24224 83584 246756 311786 25625 361167 309165 78971 25309 314756 140926 360640 25385 116554 58918 309361 266610 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling 94195 310553 300177 301059 680054 63868 84351 309295 24773 680127 116547 60350 114122 25181 363520 117273 362418 305353 309361 29260 364594 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events 64546 24498 25205 288905 288774 85471 171334 24918 59086 303496 84405 29197 365368 301289 680609 84598 25124 24835 367264 116562 25125 25712 24514 24494 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling 113894 83584 399489 57027 310738 78971 64547 24185 24842 85385 81737 25730 59109 58918 24225 64639 54226 25335 29192 29753 78963 292788 289231 25402 300802 288753 84351 63879 309295 60371 25272 50658 25522 363520 360678 25513 301059 293508 311245 25309 308690 85253 29409 83765 83576 170820 362491 117089 367767 450224 308362 501625 116554 54281 83537 363875 309259 64373 295342 84006 315691 171045 84469 117273 309361 24596 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway 114554 84353 84027 309419 317674 312754 79257 25404 312781 24205 303181 301555 50686 64086 308068 83721 266772 303811 501281 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway 24516 170582 81771 25619 304580 60465 81687 25317 81745 498576 24586 83502 25022 170583 25126 25114 500985 25124 311163 84489 292756 25295 25622 313845 25513 81504 24185 306141 361388 85385 314850 83501 314322 79114 25615 25353 83805 116590 50689 50646 25738 367218 25400 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events 680117 59328 25378 50554 29530 85435 79558 85272 25639 140590 25671 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity 296654 84353 501099 363249 501560 114483 63839 84574 298144 113938 192154 288778 361256 83724 305922 685082 363247 116464 312440 619385 25193 316742 260321 25163 361585 305999 25019 84382 497672 114206 117254 24208 361103 25677 360748 24185 363026 362827 156435 497991 58919 360552 83614 117553 64044 500569 64513 304157 300772 25573 295378 50646 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes 114636 296512 81679 85265 24185 24247 84353 83502 307505 311163 24329 83805 361517 25150 363875 25233 117273 25738 25513 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events 24516 81649 83614 24508 114495 24577 116510 25124 689314 25125 89829 24514 25094 84482 25622 84477 313845 25156 25513 81504 24185 362051 24498 25205 29469 24499 60430 362862 287398 300772 361388 24367 114767 117516 24153 25419 84598 314322 24888 25734 170538 363875 24253 24517 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway 60589 29202 171287 316539 29210 116683 366492 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway 307511 171102 25578 361765 24672 117281 114494 362817 116468 310034 288414 498411 303024 360254 301014 140583 294800 312641 287524 288003 304528 59102 85482 315969 25515 685055 288532 314856 499870 60660 363055 312538 360621 363076 316477 298534 83508 56011 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin 361765 84353 84027 58822 64462 317674 79257 312781 24205 303181 362356 113927 50686 287280 29134 83721 303811 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway 29753 25578 81745 287942 25622 313845 25522 293621 25718 24697 24482 498416 25513 81504 316369 24185 54245 29376 85385 83840 360820 25414 25467 24703 25614 85421 170538 83427 64639 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin 25361 25166 287398 29197 114495 363855 24835 116590 691998 25154 170851 362393 58960 50689 303200 24494 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods 85259 24400 83686 116556 499132 314264 83579 316218 301233 81760 89826 24717 29481 25539 64047 307401 289878 680149 79222 56814 363143 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network 499655 257649 170915 58921 362217 84495 309816 94201 24708 24827 114494 25231 362817 294254 24577 303828 24790 360254 54237 294790 25163 298850 25729 54244 114592 24890 25515 314322 50686 114212 170851 25203 363088 58919 171103 361400 81686 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events 497932 81745 64633 54258 500985 25238 29340 25388 25023 24681 29322 24400 24654 25387 24185 24680 309242 85240 81515 25734 89788 81664 140694 79113 25096 298947 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions 25619 24232 24832 116479 360647 83476 171569 24366 361969 691992 29243 25268 64350 308995 25021 25464 116591 25361 315509 25692 499271 24367 309684 25087 84349 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport 29753 25578 25576 24185 24506 84027 24669 24954 303443 81803 313017 25139 116717 56011 171105 24152 24803 85428 84006 25233 690987 500036 25522 56010 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway 24516 497932 311860 24577 501560 25126 500985 25751 313050 306400 316369 24628 361598 24629 60660 26955 170897 29733 24703 29645 170851 171337 58960 117063 313024 60465 58823 79249 85243 363855 25124 25125 25272 297518 360854 24514 54227 288669 54287 289820 360573 81732 338477 116501 25123 361710 59114 25513 360678 361617 291309 117542 25532 679934 246297 63836 301511 24918 287398 81515 25414 25734 364403 116554 363875 116590 79113 50689 117273 296456 24672 501099 117281 29431 50557 300955 25622 313845 293621 24697 498416 315707 312477 81504 54245 24680 361388 85385 298696 295347 25676 83805 313017 56011 170538 114486 314436 25738 56010 29753 25578 25576 24518 64633 24653 29340 24605 50658 296603 312812 24525 299858 314322 25150 24884 298947 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway 79558 25639 25237 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway 84353 83502 307505 316639 313494 116479 314641 296603 25513 24628 54245 65129 288124 192183 29616 308417 361598 295347 24629 26955 83805 25614 363875 171337 296456 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway 24516 116667 81649 499356 29337 50557 362046 313121 313845 293621 315707 312477 81504 117058 24185 85385 171140 24674 25676 24703 170851 314436 367901 81745 84351 81736 25493 309295 296603 25513 309165 311245 117186 292763 170929 171378 307366 314322 81515 24699 81525 313498 25155 681236 365367 171055 116689 308501 289211 54259 24675 116554 83477 363875 116590 116549 50689 24356 309361 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity 78966 306183 361882 304193 83571 308862 314904 117020 317598 287418 362893 287537 310635 296603 309696 309642 306400 299012 246217 25156 60323 360678 361617 295378 25486 140898 367072 246249 360500 362456 314903 117273 310192 290541 312108 307098 300115 361921 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin 289350 64830 25558 25012 25716 24803 116470 79557 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway 170915 361765 85471 29492 24577 56761 406162 29419 500985 84010 60328 362429 29146 307594 29650 313662 114125 313474 309459 294790 316573 29147 114587 117258 360926 311332 27256 114851 311567 116462 297893 362356 287280 140694 291787 58919 303101 360801 29382 292788 25496 289231 300802 24919 500569 689844 24333 81830 54281 679837 287287 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network 81517 171517 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 317382 85424 114494 24577 25126 50669 114483 24790 64033 24224 313050 25193 25622 84477 313845 25513 81504 24918 85385 140924 84598 25326 24888 25704 116562 25008 25385 287287 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events 24516 85243 79557 24605 25125 25272 50658 24514 25622 313845 293621 24337 296121 25744 25513 362814 29496 81504 29422 24185 305897 432361 24525 85385 314322 112400 83805 24703 24675 116554 363875 116590 170851 58960 50689 64639 56718 25636 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events 497932 81745 24672 117281 64633 500985 25388 25023 360509 24681 29322 24400 24654 25387 24185 366957 29385 24680 29448 309242 81830 85240 81515 25734 89788 361517 81664 140694 79113 361251 25097 298947 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks 25099 25098 25100 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events 25615 25216 24771 116673 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions 25619 363265 290905 81810 309816 298941 117036 29393 24832 116479 83476 24366 361969 685269 24628 680054 24771 83785 24367 24477 83727 50687 29364 24629 170897 25661 84352 25353 25216 29169 363457 296456 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway 29251 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events 24516 81649 362817 24577 25126 83681 24224 313050 25622 84477 313845 293621 81504 29376 85385 311030 303511 25676 498798 25467 84607 24703 170851 58960 25124 289014 29340 689314 24605 25125 50658 89829 25023 25513 24525 24918 252971 140924 84598 314322 25326 25704 25155 116562 25712 25150 116554 116590 50689 50646 117273 290361 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway 25236 171517 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway 58822 685055 317259 140583 29657 83508 170917 299691 60447 362093 287422 63840 252917 316351 79431 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events 81649 362896 313050 303200 81647 29448 116637 266708 25663 299626 309452 364069 291005 117029 294270 294269 303496 29197 25710 300678 114495 81736 25300 25124 367264 25125 308589 24514 301365 24494 24599 315609 309165 64546 24932 171334 24918 84405 252971 140924 314322 362491 25704 116562 25712 25385 24223 56718 24930 287287 24931 316052 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions 25619 25361 311061 25713 83727 83476 25661 25216 29169 29591 54266 362800 311144 296456 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis 81810 305679 313494 500985 299331 25622 78965 25718 24482 307403 24185 83785 360820 25661 84352 25467 83805 25614 25216 294337 85250 29169 294279 25654 85490 363457 81762 83571 363265 290905 502970 84032 361632 25412 25277 64161 81747 29393 64044 116479 361821 25513 83840 25414 25353 54250 170922 295378 363875 116590 50689 50646 117273 296456 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III 54244 24887 337868 170915 24842 293615 363287 498736 679840 309757 311569 63839 680876 81518 368057 296259 361532 302415 294515 84482 25019 114851 83516 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling 81649 24705 170915 313929 25056 54237 266713 171150 83724 84389 24681 304157 54244 84584 24185 24680 24873 297893 25271 83574 361801 116554 116590 84578 50689 25636 360801 685072 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 312916 25242 309434 24842 299331 64525 361258 367176 64345 363518 54702 83427 362891 308457 300084 308913 25163 24874 29560 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network 24516 83571 170915 289754 29663 24790 29499 94271 64539 171119 24773 24648 113984 681361 85251 305999 24952 25350 24786 497672 29227 25575 54225 24208 29228 304157 54244 292330 25492 84584 24236 304054 24506 117270 24890 25099 25098 25100 314322 171068 29169 24253 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway 308267 25272 50658 113927 25388 313121 25522 314212 293860 312974 317674 306782 497961 311658 25664 64566 116554 24884 363875 282836 282581 117273 83721 64512 303811 25400 81762 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling 81687 360552 689314 24605 81521 25433 313845 293621 29322 25718 24482 24600 25513 24400 81504 24654 24185 25149 24525 309242 24890 29149 24611 25686 85385 81662 85240 81666 25740 25414 89788 83805 50664 81664 25643 25537 117273 303634 81686 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription 679869 24516 29410 296510 81687 246768 170915 361765 84353 259243 302400 83502 679693 29717 24577 83476 24205 83724 301965 25163 161452 84382 24208 292301 84577 297893 312451 313017 362356 56011 287280 58919 25050 292907 56010 29382 29753 25578 25576 362533 27080 64033 25094 29134 114122 25587 288471 293733 85252 26198 363595 303477 299636 293897 171379 502097 302711 84420 294917 114505 25565 299766 29466 300250 29148 54284 364883 65027 362325 116499 503000 303811 313436 81686 365755 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway 81649 367901 81736 25126 500985 25124 29337 287942 24224 89829 296603 24514 25622 313845 293621 25513 81504 24335 24918 361388 29376 85385 84492 295347 81515 24888 24336 116689 54259 116554 25738 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway 116667 81649 308267 291005 311245 308463 313022 303604 304530 114495 116484 286993 308106 689314 25112 363875 311786 24245 313121 303200 300711 299626 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway 361925 288471 84027 373541 24672 312754 298696 79257 27080 192218 24577 315713 60661 313905 303539 294790 25163 313666 29432 292907 65137 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway 24628 83785 24565 25686 85240 24629 170897 25740 29733 50664 81664 25643 363875 116590 50689 117273 25738 29527 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network 81810 59086 360272 304917 24686 680246 54251 29692 313050 25717 29591 83785 81515 25734 112400 79114 364403 83805 54250 25150 316758 24884 29357 79113 54226 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins 24516 81649 24323 24782 81749 170926 64532 25289 29241 24326 366270 24681 24324 89823 54223 50672 114099 293621 29322 305509 81636 64508 24654 24185 54245 24680 309242 25686 81662 81666 25740 84352 81663 89788 83805 24703 50664 81664 25643 170538 170851 58960 300339 84032 24653 29340 25023 24514 24611 85240 314322 25414 84420 116554 363875 116590 50689 50646 85420 117273 24784 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network 94203 54251 81527 360457 246331 114110 83785 114111 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte 24516 29636 85243 307799 25272 50658 25388 300955 89823 25522 25513 81504 316369 24185 316258 310695 64563 287398 170672 25150 116554 363875 84006 64639 292994 25738 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events 24516 81687 64532 25289 29241 25433 54223 293621 29322 305509 81636 60323 64508 24400 24185 54245 309242 361388 66025 25686 116744 302378 81662 498609 360820 81666 24173 25740 24329 81663 89788 83805 50664 25614 81664 25643 85421 170538 25738 304109 84027 25402 85243 81736 25493 29340 116501 25513 309165 314322 81515 25414 84420 363875 50646 117273 25097 303634 81686 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions 25619 305078 192362 309368 298941 117036 25473 83785 24367 83727 81651 25494 25661 84352 307582 294337 316758 85250 29169 294279 25654 85490 363457 363265 290905 84032 25412 309816 29393 140433 361821 24366 361969 685004 60350 619374 360606 311144 81517 85251 114517 25621 315346 81008 315744 292406 25118 25361 304979 170921 364786 310683 24511 25353 60327 296456 56083 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling 25619 81687 59086 24366 361969 64556 25021 360606 315346 54245 299858 299606 24367 24511 309684 85253 24629 25661 25414 408210 24329 291132 83805 290257 25696 309081 117033 171052 24617 292413 363875 690158 29169 292409 362653 171045 24446 296456 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression 81646 170915 366126 294051 24577 24790 680111 24224 294515 25164 24337 497672 114851 292060 297893 24629 84352 24252 60661 29357 25631 50554 24388 117526 58919 65042 362102 24450 313666 29344 29508 25336 81780 25337 24854 83571 444984 24855 316519 293113 25319 294693 171114 299923 117180 115769 84402 64040 29467 360961 25112 363228 117279 56646 25587 114517 25724 24511 293897 64566 84578 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network 29496 690919 432361 24827 25313 24329 112400 29183 299331 59325 498596 25433 59323 24337 64022 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II 29753 501099 498736 680876 24413 25238 25172 299331 294679 306353 499497 24400 25159 84582 84581 24890 85252 363287 25573 84509 297453 294429 362981 56011 84578 303836 25050 360801 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling 308267 84353 81516 81810 24672 59086 307799 25404 315713 24668 25388 25717 29591 313121 313845 81504 311567 85385 79257 297930 140926 29357 25631 50554 25400 29753 81745 63879 303614 29610 171071 301373 308212 305614 83837 117104 499508 170714 300813 24673 297699 502531 313477 79128 64032 690516 83840 25639 291553 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions 25713 83502 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway 116667 24516 83527 54245 287398 81511 292763 366962 155918 287942 116554 25023 116596 313121 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes 116667 81649 29753 24649 25578 25576 170915 84027 25402 81518 24917 29340 81749 50658 24224 113927 25023 24681 25522 54244 24887 85245 296634 24680 290652 85252 64152 84509 311658 94165 24888 313017 140666 56011 116554 170538 116596 116549 171026 50689 64639 25639 85420 25050 25636 79240 361400 56010 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells 500985 301348 50557 313050 300955 25622 84477 313845 114246 293621 315707 81504 24185 24680 81511 85385 295347 116596 25738 81745 294270 294269 84351 25710 300678 25300 309295 29340 25660 25408 24605 56822 25023 361714 25156 315609 29434 83527 24525 24932 293860 311245 54355 304496 305450 54348 292763 361618 499537 307366 499931 366962 24699 155918 360640 116689 54259 25150 83477 363577 85420 309361 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals 94203 81527 246331 24185 81745 316258 24680 83785 25404 500985 25676 299331 54251 25023 116590 300955 25622 50689 25738 29560 25636 24600 314612 25513 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events 81504 24323 24326 85385 25313 313845 56718 293621 24329 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins 361765 84027 363067 25273 29499 303024 83712 304729 83781 89830 113927 25388 64086 24400 54244 24185 64823 65278 58822 64462 25099 300772 85252 25686 84577 297893 362918 301516 25740 361769 287643 84392 50664 305918 81664 140589 367242 25643 170538 170851 290284 25636 685491 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway 81745 29636 50556 307799 25404 500985 171455 60627 116636 116717 252881 294515 300955 85428 25622 313845 25522 29517 293621 24697 498416 25513 312477 81504 316369 24185 54245 25167 24506 85385 83840 24954 25676 25467 58844 114203 54259 686098 84006 25233 64632 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network 25267 24628 79429 24629 25266 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling 81504 85385 29431 500985 25414 65038 83805 25614 295378 296603 363875 24161 117273 94268 306400 366492 25513 304109 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling 24516 116663 116667 81646 29154 29636 81757 24672 501099 117281 24782 501560 25671 29304 499497 313845 293621 81647 81504 24185 24680 361388 25313 361598 24329 24703 83805 310131 313017 64226 56011 170538 170851 114486 58960 296648 310688 314436 64639 24330 313024 56010 29753 25578 25576 58823 81745 79249 315305 85243 64633 114856 25124 24605 25125 50658 297518 296603 360854 54227 314384 288669 289820 207119 117104 360573 81732 25522 312812 25513 291309 117542 679934 24525 29542 301511 287398 314322 24888 116554 363875 116590 65179 79120 50689 29568 25096 56718 290396 25097 24584 171492 29622 79426 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development 29753 83572 29489 292464 311860 501164 114113 266729 116565 84394 170845 64189 362558 24718 116671 301265 140908 29648 363193 361598 25696 363875 116549 29456 83462 117273 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL 25729 25118 24511 362817 114494 680876 58983 24179 282840 25414 25533 362930 83805 29463 363875 116590 295342 50689 117273 24330 114851 81762 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling 316369 287398 498331 81515 25734 364403 83805 313633 24338 54293 313050 25150 116554 24884 140694 363875 313121 79113 306636 685269 25186 304109 25513 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium 81649 81771 81504 25118 81646 360457 24185 54245 114110 170921 287398 24511 29393 85385 25661 84352 689314 116590 50689 114111 313845 311144 315346 25513 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events 24176 24553 25360 79121 24180 116693 116692 83709 619382 171097 305967 25388 25477 306436 300955 305367 685269 314543 94268 366492 25387 309242 25313 81662 360820 81666 24329 89788 83805 287443 24446 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network 81649 117028 296137 311860 170915 24165 362817 24577 114483 315713 24790 360254 54237 140583 294515 29147 292041 362675 500305 25466 289218 308016 114851 83631 79245 24883 64158 64547 83764 24177 25247 311567 116502 303412 29455 298652 361594 298696 364052 362485 24439 499870 315203 300257 59109 313017 24617 83427 289508 246097 155430 246334 64314 24708 114494 192218 689314 25172 58936 24648 309165 24887 293508 64369 309757 25515 84598 314856 25203 25084 291553 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events 81649 81745 85243 114495 689314 24605 303200 293621 246759 25513 24400 25387 24185 24525 25686 29397 25740 305236 83805 24703 50664 360918 310131 81664 84475 498335 64226 245920 25643 140694 116590 170851 296648 58960 50689 56718 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events 24649 81504 25578 293508 289747 24918 85385 297893 25126 24888 83681 25261 171081 54259 246144 24514 690345 298545 25622 84477 24253 25636 25513 56010 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling 81649 497932 81749 313050 25388 24681 25372 60323 24600 24400 24185 24680 309242 25313 81662 81666 24329 81663 89788 83805 81664 170538 140694 292661 24816 63889 81762 25544 25238 29340 689314 25023 25522 25464 59114 25361 81830 85240 81515 25734 25155 364403 83579 25150 171107 24884 363875 79113 85420 117273 25636 303634 56083 298947 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling 29753 24553 25578 25576 305078 83502 192362 309368 309816 298941 64026 117036 25473 140433 293621 114517 24566 24337 25513 25724 29496 81504 300999 24185 24493 24680 24511 85385 83840 25313 25271 24329 83574 307582 361801 313017 316758 56011 363875 24660 294027 56010 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway 81771 361765 362817 315713 303024 287871 292887 29517 293621 25729 24185 24680 25435 25467 24703 310131 313017 64226 56011 78968 170851 114486 296648 58960 312927 60445 83516 300253 56010 29565 29753 360827 25578 287436 298514 25576 24855 64031 81745 315189 315170 297960 24919 84351 303206 117044 362164 140942 84480 304714 117043 24605 116636 117045 24525 25309 83840 116590 50689 25096 56718 25097 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway 309452 360640 361765 81736 309361 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors 24516 170915 315713 24790 24224 83584 24324 399489 114851 54244 60430 24873 84577 24329 303539 24617 29508 25336 25337 25389 246097 24855 246334 64625 373541 114503 171355 24827 24708 299923 294254 291105 58936 85251 83628 24887 288471 171293 170929 314856 25353 25203 81686 25404 50557 24205 362675 24177 25737 116502 25245 24842 25098 29455 363026 24484 313017 362273 292949 289508 25405 116589 24446 293625 78963 24553 25166 60584 140942 114856 171109 89808 83803 25112 364420 295341 60421 140923 296953 685474 79122 282817 314465 114122 170824 287765 310159 361843 366492 245956 289717 298784 24404 299976 29424 362686 305025 364681 298182 81709 500348 363133 81685 297822 293897 60434 171379 502894 24888 294518 29619 309871 288479 303310 501502 287954 691278 500715 24811 303836 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events 81646 24611 302378 29340 84420 64532 25289 29241 314384 54223 305509 25636 81636 64508 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly 81679 24553 84353 311860 25402 83502 64633 307505 79121 311163 25751 191575 29650 311494 293621 25718 24697 25453 84471 54244 29448 24716 25313 361598 83501 25454 24329 81663 83805 116689 25054 56084 25150 363875 24225 58946 24483 314028 171045 306871 307585 25335 303634 65047 501506 304109 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling 85425 298687 114559 25502 314642 293056 84027 170845 29431 25493 83709 25112 298850 497672 306562 311191 85265 24185 360962 114592 24842 84509 363193 314856 261730 25676 311546 25636 171103 289997 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling 497932 24516 116667 81649 362788 681070 498749 171369 24235 85243 81736 24577 25493 689314 60371 25272 50658 311786 25513 309165 78971 24185 311245 287398 24918 25326 24888 360640 84349 171136 116554 287287 298947 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network 84584 25149 24232 58850 266773 361825 117553 171379 25490 313929 83724 117274 303518 361509 360815 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases 114592 292554 261730 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events 29753 25578 81646 25576 24855 84027 54319 301574 24577 293631 314621 25595 60328 81751 299331 680407 301535 499073 317589 287871 296732 114562 59329 292887 303605 310615 360635 501146 24890 24842 171293 313017 64226 56011 50554 56718 25636 60445 56010 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway 287989 313633 24338 306636 25186 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway 81649 81771 81646 291713 499652 501099 192204 114495 116671 289014 24605 140908 499497 314384 303200 293621 24525 81737 295347 314322 24703 170538 171337 116590 170851 83810 114486 314436 50689 29568 24330 171492 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway 116667 308267 84351 113894 81736 363855 25404 64044 25124 309295 24835 306886 60371 308909 246756 311786 313121 303200 293694 25522 25625 315907 57027 312937 361167 503027 170920 94193 282844 309165 156767 78971 353233 303604 116484 294917 83537 83427 84006 309361 266610 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks 81646 24413 24790 24592 64678 114587 25735 25634 29637 25756 24185 24651 24158 24177 24506 54315 24856 25363 25099 25757 25098 113965 25100 117099 24813 29251 24190 362282 25351 25559 24252 83535 25628 25685 24817 24385 24186 308579 24253 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events 24516 116667 81649 114559 84353 29636 83502 29431 307799 363509 307505 500985 29271 292756 24205 363925 65172 29524 303200 293621 81647 361598 83805 24703 79225 114486 303882 117515 114116 360891 25509 25252 304109 84027 114495 363855 29340 50658 297518 296603 360854 309168 54227 288669 289820 81732 25522 312812 29432 360678 25513 117542 301511 287398 83840 310621 25414 116554 24884 363875 116590 50689 25096 56718 290396 64632 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events 497932 81687 304580 29431 25126 29271 313050 25388 65172 84482 116546 25622 29322 315707 24400 24654 24185 54245 311567 24772 25686 360820 25740 83805 50664 310131 25614 81664 64226 56084 25643 140694 83427 171337 296648 64639 59076 360834 54289 246772 114590 81745 294270 294269 25710 300678 85243 25300 25124 25238 25125 24514 25522 25156 315609 25513 24932 288774 24918 85240 81515 24699 25414 25734 364403 116689 54259 25150 171107 24884 363875 60628 64373 79113 295342 50646 117273 56718 303634 298947 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases 81649 29753 361680 25578 81646 362733 25576 24855 501099 315994 25085 171046 289014 24471 689314 24703 313017 56011 171103 56010 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling 24516 29382 292788 84353 295445 361765 25496 364952 289231 84027 300802 362533 24577 84010 303024 24205 29650 113927 313121 54244 25489 287102 297893 79257 497961 363193 293897 314322 312781 58868 24881 24817 29466 116590 116549 25682 50689 58919 114557 83721 29192 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms 246097 311860 170915 361765 246334 114090 24165 299284 25277 313777 84351 303285 81785 81528 362280 27080 289586 313689 315713 303687 24790 29499 24314 25112 29146 296732 79122 25163 360606 308016 114851 25724 24887 83764 311567 24873 29326 29455 361594 25515 297930 314856 24484 170538 292949 116589 307585 309361 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway 116667 25166 170915 81516 24508 500985 25124 311865 305896 25125 287942 24514 309168 24245 25622 24494 25513 54244 24185 300772 252971 116465 295347 84598 171140 306722 362827 25712 170538 171337 116590 170851 50689 24253 24246 117063 56718 25400 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway 314961 24932 64310 116692 56042 83800 309451 246310 293344 308578 363875 116563 64154 361577 116561 360658 25097 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events 24516 308267 25166 84351 114495 113894 81736 309295 116725 313121 24494 25522 363520 60582 25466 361677 266806 117022 25513 679539 309165 364867 314870 300177 301059 24493 311245 303604 116554 84006 309361 25663 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network 24516 81649 81646 170915 366126 85471 25126 116671 24413 313929 299331 83724 260321 29517 24497 29173 114851 54244 24185 24177 301020 24842 24367 287701 24683 84577 297893 313017 117526 300339 24330 24664 79240 25576 25544 84027 303496 24508 81736 25124 116553 689314 25272 140908 25295 50658 25464 309165 292925 24887 361042 24498 304947 293508 116700 361810 24918 685179 363002 65035 361688 690244 25517 314322 314856 171379 287702 116630 116562 25712 116554 171068 116590 65179 50689 287287 25636 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 114559 116743 85243 64633 500985 24605 84357 81920 313474 313845 293621 296121 25513 81504 292925 306141 24525 312574 361831 85385 25313 641452 60668 24329 117277 171565 83805 24703 305454 25614 282834 56084 85238 171136 140694 29491 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network 307660 314818 25619 313978 170915 498940 24312 300947 313479 361745 362817 24577 24790 54237 680111 25193 81758 362675 399489 25163 300711 497672 114851 54244 25729 60430 315969 116698 297893 116651 362485 24252 360621 303539 24617 291787 317376 685491 171102 78963 83571 84495 24919 24708 64026 114494 27080 291105 300266 364382 288471 294568 309757 303310 316273 113902 291955 24912 296344 299313 362720 365320 29261 54238 360739 312603 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway 309165 361765 24680 311245 291912 84351 85252 81736 84509 307366 25493 309295 24835 362491 60371 81920 83477 25625 300711 312937 309361 266806 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling 25150 116683 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells 500985 301348 313050 313845 114246 293621 315707 81504 24185 24680 81511 85385 295347 116596 25738 81745 84351 25710 300678 25300 50669 309295 29340 25660 25408 24605 56822 25023 361714 25156 315609 29434 24525 311245 54355 304496 361618 307366 366962 24699 155918 360640 116689 25150 83477 24223 85420 24930 24931 309361 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase 24516 367846 311860 363067 59086 290232 500054 297758 24577 307798 287522 498411 290794 24790 290046 296384 290027 299331 83712 307861 305963 294800 363247 301965 308755 399489 361585 300711 25019 24883 64012 24185 64046 85482 24890 84577 297893 25313 24329 60661 25631 290284 58919 685491 29753 83571 24508 81736 64556 361403 113984 83840 314322 116562 25712 681012 116590 362391 50689 56718 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein 24516 81649 311860 170915 366126 24672 94201 85424 362817 361825 501403 114483 317256 114502 294276 499497 24710 294790 302553 84350 25193 24265 114512 399489 25163 315333 317715 114851 54244 25729 81647 337868 297893 24252 24703 117526 24253 58919 81809 685491 367218 29382 24553 83571 24708 114494 25574 689314 64033 291105 25295 50658 25094 25350 309757 314856 25664 171379 116630 84578 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling 116667 85245 296634 363249 25573 24917 362827 301373 29357 116590 25631 50554 50689 25281 24666 301056 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network 24516 81646 312916 170915 24323 25563 24790 313929 83724 24644 54702 301965 308913 24778 312382 25735 79431 25059 54244 117095 114490 298199 361338 24335 24185 313495 170913 300807 60430 25608 25026 24772 24268 83785 58813 24645 25630 25741 24189 117276 25685 24825 24385 24617 25631 50554 29560 25242 24451 299923 84480 500965 64678 24333 25587 24599 25159 25498 84582 309684 314322 54281 60628 24356 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway 83572 84027 266729 116565 362558 24718 363855 116671 500985 140908 287942 310635 309168 360606 24410 25513 316369 24185 24511 295347 24409 116457 25696 25150 116554 29456 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway 116667 287398 84351 85243 64044 309295 306886 364420 295238 246775 308909 117279 116554 246756 116590 311786 50689 309361 266610 25513 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling 24400 81649 50658 81648 116554 24611 689314 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP 24553 85243 25126 25124 24917 362896 25125 54287 313845 78965 24697 25513 502531 54244 81504 25118 24628 307403 25532 85245 24506 24918 300772 361388 83785 24511 85385 25313 685055 24954 84598 25326 24629 24329 83805 116666 117063 24446 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling 24373 308267 81516 84027 59328 85435 85272 363249 63879 140590 25671 24668 303614 171071 313121 83837 499508 24666 301056 296634 690516 266803 25296 363455 367100 25495 116590 50554 25373 29373 310681 25644 81507 117275 308739 50566 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events 24400 29636 309242 81662 29251 85240 81666 89788 363925 25537 117273 303634 81762 FSH%NETPATH%FSH FSH 58960 116700 25233 25447 25449 59077 59076 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog 360715 309565 679693 299180 290284 84353 25238 25255 301516 140589 304729 84399 293047 25388 84380 361769 497991 246209 25636 89830 291936 29753 25203 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor 297893 24471 24185 25614 24208 25513 81646 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor 290280 311412 84471 302415 291464 24791 24518 305614 497672 25705 300947 313929 59086 81809 25717 81810 29610 361831 641452 81920 25573 24873 85252 313588 24577 296634 361415 170714 50662 156726 360725 290875 361765 363088 313477 25406 311071 171102 362675 25281 24890 25388 297893 24185 25614 24208 25513 292763 367218 294515 314322 308411 24516 24517 24790 81745 500695 314621 24708 24842 81647 54245 287280 25414 362356 25404 300084 303200 114495 84027 499508 24356 25389 81758 79128 140670 287069 94201 114483 114851 25729 361389 83726 312916 301535 307505 297357 59329 84482 685691 29741 289752 25639 362199 25318 171071 295062 308404 296558 305420 25735 500126 24468 290744 24917 50554 367100 499497 116590 64466 50689 29508 25336 25337 191575 307799 314642 288671 304490 365894 116551 315713 24666 117104 25521 140926 29699 361109 690516 360820 362738 58919 25615 TCR%NETPATH%TCR TCR 58960 84353 25255 24185 25614 25513 81646 81647 54245 84027 29741 116590 50689 360820 24165 362111 29434 361714 311030 295378 295975 24253 117268 288305 363616 309361 498287 680697 294048 54241 116596 54244 287942 81649 63835 362966 140866 317335 307483 25751 360509 312477 25416 498003 29443 24330 24334 29214 29210 289352 50646 301737 306204 308666 366889 94165 316258 311860 499537 24377 292658 295338 29662 81511 500449 293953 54348 81504 83527 306400 56611 290527 361838 301252 361384 84351 54259 363577 25262 25326 83628 313050 155918 500965 24534 362456 171105 289227 81515 24571 300955 64556 24159 291044 24211 311658 24213 81736 25493 81525 291015 29431 313934 309642 498075 79115 84582 24161 24645 289021 64161 25630 25738 29337 309255 498232 315959 310695 24675 360891 170538 299121 85421 116554 689314 170851 81918 303678 310655 362524 116689 25622 117255 25167 24699 171125 29437 24703 84509 295347 25676 309165 83840 117099 83841 305450 85385 338477 361574 313845 83805 25124 311622 25155 84492 64678 292925 316531 305311 58819 361517 25156 296603 117538 25578 301348 365548 494338 64158 289125 315579 295625 286975 500985 171136 290834 362491 501872 114559 291078 83477 155183 360871 246142 290361 310688 300732 29402 497761 56084 308468 25710 315609 300678 310635 24932 54236 303747 25660 366962 293783 25408 56822 29548 363509 304546 54237 361251 84477 360950 299258 LEPTIN%NETPATH%LEPTIN Leptin 84027 287659 116719 25718 25608 65172 24600 50678 25738 313929 29337 116554 81504 24185 84351 25614 116590 24890 83840 25326 367218 85385 65248 78975 29340 117269 117268 83805 25124 25139 24329 116636 309361 25150 50686 117045 29304 25467 84598 24337 140908 366624 25493 25419 81666 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor 362817 171081 361597 293621 24680 25734 170915 24514 25023 252971 84427 81771 79113 84357 64030 116554 294797 24884 56718 25094 116680 305828 296072 305539 25622 24336 690987 297176 60450 60427 81521 24703 315655 24185 24918 60352 25676 25126 25513 309165 54319 83840 364420 307200 500616 24516 313845 83805 25124 363616 84492 81647 54241 54245 287942 81649 117538 84027 171136 311860 116590 54259 25326 116636 25150 29304 BCR%NETPATH%BCR BCR 362817 25738 25734 84353 25023 81771 170538 85421 116689 24185 25614 25676 309165 81646 83840 292763 171150 294515 305450 114203 314322 85385 307366 308411 407756 24516 314436 24517 313845 289211 314641 81745 25124 313874 305269 309361 301333 24708 84492 353256 499356 81647 288077 54245 117282 81678 25414 361400 287942 286974 81649 25156 298947 116723 25309 365948 84027 301348 85420 24887 361659 303836 312477 116637 25125 367901 317676 140607 690575 309419 89812 64026 499931 58918 83477 293618 289014 308501 313498 681236 171055 29741 81504 84351 116590 363577 25262 313050 81515 116636 25150 300955 50686 29304 291044 311658 TNFALPHA%NETPATH%TNFALPHA TNFalpha 24680 170915 641452 81920 25573 361765 24918 353256 116596 54244 81649 317335 24887 312477 64026 289014 252961 84581 313867 303602 116633 117514 314417 246240 140657 81504 114562 282844 679572 116549 499069 79129 301252 140610 292747 312641 301225 29372 361810 313264 293860 303024 362607 25586 83581 362247 113900 689577 316033 29476 84577 287707 305751 299827 60371 78971 63879 81736 84020 25493 85245 361055 307449 29431 291885 288532 309168 305606 116670 316241 25233 58934 685607 498109 681193 501601 94338 29355 29568 288753 29425 117263 25581 29677 83806 287984 287670 116554 307821 287772 365388 246273 361711 680611 64302 29753 499374 25622 81774 684988 64625 301515 304005 297893 313245 24471 24185 171379 361825 25614 301020 685179 81646 303518 24835 156767 50659 116484 56010 313666 24516 293960 313845 24517 305451 83805 408217 25124 64314 83582 360491 24708 353233 309295 287367 287280 361925 314756 362356 266610 498206 25404 117279 246244 315291 25578 114495 360600 308761 115771 310877 25069 304893 361167 301246 287069 303285 363984 266764 289924 305240 114089 303604 64640 311567 171492 308267 171121 84482 50658 314384 305584 311245 140934 299331 83427 361388 24888 25271 56011 362110 29496 60328 25576 25402 116590 50689 116551 24329 315713 25467 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin 114523 29431 64315 85243 366508 60664 29376 24680 170538 24884 56718 29753 25622 24185 25614 362675 24208 25513 314322 85385 24516 83805 81649 298947 25578 311860 29741 361388 56011 81504 25576 25402 64639 363875 308015 116590 294027 306871 50689 313633 313017 114517 25724 305506 117273 309368 307582 140433 298941 24329 25473 116636 305078 25150 117036 192362 29236 117045 29357 25631 25467 24553 24337 300999 64204 297383 81818 291926 WNT%NETPATH%WNT Wnt 24672 25671 161452 497961 81679 24680 313121 301334 113927 303811 25023 83502 293897 314212 308796 170538 295691 25236 299858 25388 116554 293649 24884 362550 293992 298696 24668 25636 679869 114554 312974 24681 84402 310552 29382 84382 24881 114487 24185 24882 64566 317674 79257 58868 64558 282581 266608 114107 363062 24516 114483 309419 56011 60328 363875 117273 311658 58919 IL6%NETPATH%IL6 IL6 302415 58960 497961 25738 313121 313929 25734 170915 170538 79113 116554 170851 25622 297893 24471 24185 24918 24208 25126 25513 83840 294515 314322 85385 24516 171369 83614 24498 24499 25124 25205 308106 24708 287398 367786 502531 29517 89829 54244 81649 25156 114495 84027 25125 367901 500985 50646 84482 29741 299331 361388 81504 362110 29496 64639 363875 116590 50689 84477 81515 116636 25150 117045 140926 84598 24337 81736 TSH%NETPATH%TSH TSH 25643 50664 25617 25718 25360 25608 24703 64202 29144 84351 81646 50689 24211 303634 362938 81662 81663 25686 303200 81664 114495 81666 EGFR1%NETPATH%EGFR1 EGFR1 114613 29219 680309 114486 288774 24600 81803 57027 362817 316742 64524 313494 293621 301509 24680 305679 191572 140898 24514 63836 291610 252971 680860 84427 298694 81771 304983 310838 84357 362393 64030 290467 316384 316369 56718 304775 313994 292130 303517 296501 363425 58945 81634 298019 306886 312721 361598 500989 24918 316101 685611 25126 312790 54133 363466 689959 361724 500261 115769 207119 25407 314436 116673 291309 298875 315530 64681 301333 305178 298947 58918 58960 25255 297893 25614 25513 81646 314322 24516 24790 81745 314621 24842 54245 25404 303200 84027 499508 79128 140670 303604 64640 311567 84482 50658 29741 314384 361388 56011 29496 64639 363875 116590 294027 306871 313633 25724 117273 29357 25631 24553 64204 81818 85243 366508 302415 60664 29376 24518 81679 301334 83502 24577 24681 29382 24253 83614 117268 308106 54241 89829 287942 362938 81649 317335 312477 361677 360640 24224 498798 315305 24252 84584 50646 680511 54226 306204 83501 116777 361370 65169 81732 311860 289820 83617 303882 64665 319110 303479 294981 306141 363599 360709 50685 117542 306400 60383 171565 29271 308069 316213 314850 84014 192277 503027 293619 361617 65046 313050 83800 155696 500965 25528 500943 315707 360537 25308 81515 311163 365657 300955 312937 308578 500988 291044 58948 24211 309081 307562 29652 81736 24799 306636 25313 366492 29431 287986 313934 304815 304786 60465 24333 60334 24161 312279 316539 289021 24338 287989 25630 24186 25738 24189 29337 360842 60443 295053 116504 310695 59265 309639 29579 170538 315326 192645 85421 292699 116554 300656 79209 170851 310131 81918 315696 303678 362156 117552 259225 116689 24392 304883 117255 362046 25167 296199 287710 498416 58844 24703 83709 362342 296571 315298 309165 25176 83840 296654 117277 83841 25380 29424 79124 192154 25462 64312 65038 24954 360606 24511 64363 64678 499747 79120 24525 300242 25626 361517 287702 25156 294853 296603 299012 300438 25578 288010 317598 365548 26198 25745 315840 25489 315579 29542 295625 303259 314961 116550 171136 298744 290834 302422 24629 64355 114559 297911 291078 64303 29525 287925 360871 25096 25097 290361 117540 313729 29642 498576 288908 360605 308468 362860 117541 315970 308444 84006 207122 304282 363855 501563 291356 50557 308959 24697 114767 360406 304546 94202 54237 192183 25739 361120 64633 116546 65248 29622 78975 83712 114488 117269 81822 360857 24329 64205 116636 83789 25150 501560 50686 81773 81778 502110 288663 84598 25216 24337 24771 140908 362271 252855 302363 81921 ID%NETPATH%ID ID 304786 25389 81758 24703 58960 362817 116590 50689 314436 24708 362871 63839 170851 25585 299766 25631 29577 83499 679869 680111 303614 171046 IL9%NETPATH%IL9 IL9 24500 362896 24918 25126 116590 50689 192218 IL3%NETPATH%IL3 IL3 84027 64547 25159 366508 65199 312477 24705 24672 24778 84607 171081 361597 293621 315305 24680 25023 84482 29741 170851 83427 361388 25636 24888 25271 116689 56011 24699 64639 25614 116590 54259 25513 81646 84477 85385 81515 50686 54245 89829 287942 81736 25578 IL5%NETPATH%IL5 IL5 84027 24887 25751 58960 25125 24653 500985 25290 293621 24497 114103 25734 364712 50646 84353 252971 81771 170538 29402 83427 81504 25622 24703 24918 25126 83841 294515 85385 24516 314436 313845 25124 81515 25155 50686 81647 288077 84598 287942 81649 81736 298947 25493 25578 IL4%NETPATH%IL4 IL4 24356 366508 29376 25125 500985 498798 24252 29337 84584 679950 170915 680511 25372 24514 64635 287287 252971 116553 252963 170538 366126 60628 140924 116554 689314 116689 25622 64639 24185 25614 84351 116590 25676 54259 50689 83840 85385 171369 314436 24253 309361 25155 81647 54244 84598 81649 81736 25493 IL-7%NETPATH%IL-7 IL-7 84027 58960 29376 25125 171136 498798 84482 140924 25647 294797 170851 64639 24185 24918 116590 25126 25513 50689 25326 294515 85385 25124 25150 50686 25467 NOTCH%NETPATH%NOTCH Notch 84027 25125 25671 161452 170915 24514 54226 114125 25177 289231 363067 29147 170905 315119 29492 406162 81526 54281 311332 316626 310405 292788 24185 81751 116590 309626 25513 309165 294790 50689 24919 300802 689844 362149 360801 303101 83805 500695 84577 287280 25631 29577 362356 81736 300084 171046 IL2%NETPATH%IL2 IL2 85243 366508 60664 58960 29376 362817 116554 170851 56718 116689 25622 24703 24185 24918 25126 25513 309165 81646 294515 311030 85385 24516 314436 313845 81647 54245 29517 89829 287942 81649 25156 298947 24356 500985 24224 498798 25729 50646 29741 140924 299331 81504 116590 50689 25326 84477 313050 311021 290364 304063 24654 24413 81515 116636 116562 25150 25704 25670 117045 500538 29304 25522 25467 367264 84598 301965 316521 81736 500526 288516 TSLP%NETPATH%TSLP TSLP 362896 24185 24918 25125 25126 116590 309165 50689 25124 50658 116554 117045 170851 367264 81649 81736 25493 309452 RANKL%NETPATH%RANKL RANKL 297566 301227 311786 362788 117516 113894 25614 313121 308267 366126 309361 305584 116554 311245 25094 81649 81736 309452 25341 IL1%NETPATH%IL1 IL1 312477 314870 361677 24493 360640 24494 24653 25663 60582 363520 362418 301059 300177 362081 305835 171492 305549 308267 24786 171121 116725 50658 679539 29741 117022 305584 116554 311245 140934 24185 84351 116590 25513 309165 50689 24516 309361 24708 81647 81649 81736 25493 303200 114495 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis 362843 29592 64203 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway 64524 292804 25059 362383 83688 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation 29347 FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis 29261 361472 24312 81522 680308 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism 25059 24189 25659 24190 114860 298003 24191 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway 287398 117045 81518 315994 81649 315305 311245 289014 60352 24471 689314 308463 29513 114495 314436 25435 314384 500526 25663 308106 313121 308267 299618 501099 499497 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway 315994 81649 289014 24471 116590 310688 50689 83785 60664 24703 170897 313834 292658 84574 24600 314612 29560 360820 64363 315189 361632 289021 25023 293783 24653 25522 65052 293621 85420 170538 29340 24681 81749 84006 366957 298947 25513 29741 25738 29337 24680 85243 363875 366508 170851 58960 308589 24605 85421 311193 114486 25420 300115 24356 58918 24185 25614 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway 24499 24498 83571 114103 309361 24497 114851 289014 25670 25084 287287 286997 25233 501560 314436 500526 299618 501099 116590 50689 24703 24600 64363 85243 24605 114486 24185 81771 58840 294515 84351 85385 56718 81745 25467 116562 25124 313845 25125 29385 304786 54258 84027 29414 308716 288774 29197 367264 365769 116558 362871 366126 24493 314322 116553 171334 25126 245983 171040 24918 304091 362896 117539 25325 499931 117269 246144 314711 25704 24577 25326 155140 29376 171060 252963 317203 25647 25205 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis 501601 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis 304024 290868 25374 29421 361338 289352 289219 685245 25709 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway 304081 360616 81636 24239 25686 29553 84429 24400 25549 25636 29717 81721 25103 171131 54239 25102 25590 25101 25432 24318 24668 293860 309557 59317 313052 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis 29230 364764 310645 291211 83791 29580 81681 81726 29637 25675 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway 29528 25624 298521 54257 29559 685180 366432 24415 78957 84012 24803 292483 29628 29627 24406 84487 24412 59312 24411 29482 24410 25550 24409 24408 29483 266767 24407 29629 25012 83730 64630 116500 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis 293820 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle 64033 25193 299334 25729 296883 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 24605 81649 114851 60352 689314 24185 25233 29513 81745 60664 29414 25729 24842 497931 246334 84353 362675 50557 24672 24673 361632 24525 289021 685055 25405 24708 116720 140941 65052 300711 293621 362817 680111 298947 25513 29741 85243 366508 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis 498805 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation 81632 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway 24448 25679 114120 81678 309242 25031 24655 84587 140693 81666 114633 25262 497197 81662 24400 25023 25522 85420 170538 29340 85240 24681 29322 81749 24654 84006 83579 690825 114119 58979 79218 25738 114117 29337 294962 24680 60449 81667 245986 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway 25636 29559 25031 81666 25023 25262 81662 293508 24418 24414 24412 266668 501563 24411 25521 24410 24409 24408 24407 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response 287398 81649 60352 689314 24653 29513 114495 314436 25435 500526 60661 29467 25124 116554 299618 303200 24577 116484 50658 24224 24516 499497 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway 114120 293508 501563 81636 25686 81664 29553 64199 84429 84420 24400 60448 24679 25636 29699 25323 25075 24473 50664 25643 83579 690825 114119 58979 79218 114117 294962 60449 81667 245986 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway 114120 309242 25031 24655 84587 140693 81666 114633 497197 81662 24400 25342 25023 25522 85420 170538 29340 85240 24681 29322 81749 24654 84006 83579 690825 114119 58979 79218 25738 114117 29337 294962 24680 60449 81667 245986 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway 114120 25324 24611 83579 690825 114119 81636 58979 79218 114117 294962 60449 24400 84420 81667 245986 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling 293508 25521 81636 25686 64199 84420 24400 24679 25636 29699 29717 50664 25643 83633 50599 25398 81657 257648 64532 25289 29241 305509 54223 690825 58979 79218 114117 294962 60449 81667 245986 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway 314432 295686 298317 312647 289623 363836 116725 287927 117553 292588 305268 294331 64631 295704 361831 81816 79435 81920 641452 296368 361013 360847 308384 308508 301000 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway 312451 316527 303470 83502 303811 498013 294732 29437 84426 362268 117026 81679 25406 305338 282822 161452 25496 81822 29492 56761 406162 288227 29192 81751 54226 292788 300802 29392 289231 192218 89821 140933 84494 299858 29216 89823 500047 26955 317674 29275 287876 84027 25365 79210 312781 24882 58868 293649 114487 84353 303181 64558 316526 64566 315196 364754 266608 114850 282581 293990 291678 59323 24881 64512 282582 116777 89787 83469 679869 303586 287357 289820 315294 116466 140584 83721 83616 192183 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation 266603 64040 65183 291450 24188 29539 29408 25375 298079 29253 25750 299699 116676 685750 361571 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 24842 246334 362675 314856 304798 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis 362843 29592 64203 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization 314800 296259 311569 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis 171053 294088 360639 360511 METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle 50655 64831 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation 25679 81678 81649 309361 60352 689314 25262 29513 116554 116590 50658 50689 24516 24703 64363 25023 293621 170538 25272 295378 116689 366957 81515 298947 296603 171492 24699 303604 29337 25156 25155 85243 361794 363875 499356 366508 367901 170851 81504 58960 681236 365367 24605 171055 308501 24674 24675 25493 84351 313845 314322 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation 24842 246334 362675 24672 24673 116636 24855 25520 65248 24185 25233 60445 78975 83803 64562 58845 83840 29414 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis 24539 85240 85311 29322 309207 24654 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism 300089 302915 300741 291095 501167 363145 MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing 302670 313056 361995 292729 362223 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation 54244 368158 79462 54702 308457 29560 308913 25242 24874 24185 25233 56718 116484 29414 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism 680668 305889 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor 362339 310616 316216 170844 361580 81674 316123 306516 303918 83503 498109 689030 294236 288651 361420 373541 309638 25521 24679 54244 29699 361365 500131 306542 499766 366856 299347 288533 170915 316711 81673 83828 307485 83830 681193 171152 295324 690966 140938 117526 680050 314638 362165 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway 114120 50664 25643 24613 24664 83579 690825 114119 81636 58979 79218 25686 114117 81664 294962 60449 24400 84420 81667 245986 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation 361523 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis 297417 360518 306164 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis 24221 25504 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion 24399 316304 UNTITLED%PANTHER PATHWAY%P00019 untitled 25679 81678 309242 25031 81666 25262 25233 81662 293508 25521 116590 81636 50689 64508 25202 24703 497757 84420 25523 24326 24679 25636 366270 29699 24324 24600 24323 59320 50672 66012 64363 24611 25023 24653 25522 64532 85420 25289 170538 29241 29340 305509 24681 54223 81749 84006 24680 170851 58960 24185 29414 85240 29322 24654 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis 24443 TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis 29261 24312 29244 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway 114120 309242 25031 24655 84587 140693 81666 114633 497197 81662 64199 24400 25187 29581 25023 29595 25522 85420 170538 29340 85240 24681 29322 81749 24654 84006 83579 690825 114119 58979 79218 25738 114117 29337 294962 24680 60449 81667 245986 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway 360854 54227 288669 311716 25150 301511 294732 311061 313494 499431 307459 294279 25654 499271 81824 309684 294027 366474 81822 298069 361251 314961 363265 83805 306628 290905 84032 293860 25272 171492 303604 287398 29513 308106 116554 303200 50658 50689 60664 24703 360820 64363 361632 289021 25412 685269 170922 84352 65052 311862 293621 309081 362800 305679 25404 287942 54245 170923 366957 305104 298947 313592 25513 304021 29741 85250 315707 85490 309368 85243 363457 363875 307582 366508 364786 170851 63836 58960 310683 361303 24605 81634 291245 117255 114486 25473 305078 117036 362973 316758 192362 25614 688429 362584 58840 309816 140433 85385 298941 315744 295347 498564 171337 306204 64187 313845 246310 303553 362271 64310 170568 287876 57341 114517 25118 170921 79121 25661 298101 60379 685004 64350 25021 295588 117273 362993 298859 360606 64373 311144 295342 315346 81008 25724 501132 361568 50646 308995 314981 25713 296456 25683 24511 25414 361821 294337 361517 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway 309361 307459 286997 25233 501560 25676 300955 25266 24628 25267 363735 295635 290771 79434 500943 315532 502916 24629 500287 363616 362893 366962 361944 85424 316369 50686 312108 304815 311529 307016 170909 292721 25272 246249 295378 299012 289342 366142 296603 302811 171492 295297 689210 295965 25156 246271 81817 299117 140934 84598 81504 84477 25597 361388 114858 207122 24514 314903 83840 497931 25679 81678 289014 25262 314436 314384 500526 308106 299618 116554 501099 116590 50689 24516 60664 24703 314612 64363 65052 293621 298947 25513 29741 25738 29337 24680 85243 366508 170851 58960 24605 311193 114486 300115 24356 688429 81771 58840 84351 85385 81745 25124 313845 25125 304786 84027 288774 367264 314322 25126 24918 362896 117269 24577 25326 317203 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway 294732 29437 81822 81721 25103 171131 54239 25102 25590 25101 85426 60422 50690 299509 65261 64574 497974 294010 310178 24261 295417 170945 79557 501699 25485 25484 25017 25132 315840 29275 266714 287876 498834 25365 171296 289785 314654 25753 315820 29422 54240 117057 192253 360634 65024 304551 498806 29605 311570 79433 24582 691644 24583 360543 29556 29557 252942 25745 308572 366069 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway 84598 367264 24514 25124 25326 25125 25126 24918 362896 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism 361253 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis 58835 304429 293820 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin 114523 311658 295382 25311 306534 60664 497931 361632 289021 366957 298947 25513 29741 60630 25738 114524 29337 307989 361400 85243 363875 305897 366508 361517 362049 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis 113918 29323 292902 25693 24898 282712 83511 664630 25549 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation 368066 396527 574523 396551 24299 84493 286989 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism 361253 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis 25331 171347 81522 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase 360854 54227 288669 301511 294732 29437 81824 81822 296078 288057 81762 29431 29433 297518 29432 498736 311450 29214 317189 64303 292756 81531 685936 291926 25537 246118 296554 366624 29271 29332 117558 307351 79423 291081 307483 65172 366957 363875 29275 287876 25365 498806 29605 311570 79433 24582 691644 295342 24583 360543 29556 29557 252942 25745 308572 366069 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade 170851 58960 501560 81771 314436 314384 83840 25467 303200 313845 116590 25676 50689 24703 314322 25151 117269 24483 25718 24482 24506 24954 60663 29376 317203 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway 84598 24514 25124 25712 116465 360697 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis 24311 24848 317675 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides 289801 499956 295620 83782 85269 685679 317237 304944 311864 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway 293508 24418 24414 501563 25521 25686 81664 24400 24679 25636 29699 59320 25643 25398 257648 24407 29629 25012 83730 64630 116500 29528 25624 298521 54257 29559 366432 65277 24923 84012 116638 24803 116470 50688 29628 60590 29627 81672 24406 24419 24417 24412 54234 24411 29482 24410 25550 24409 24408 29483 83579 690825 114119 58979 79218 114117 294962 60449 81667 245986 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway 287398 314756 311786 81736 309452 309361 364420 315305 78971 25233 116554 303200 116590 50658 50689 24224 24516 25023 85420 170538 25151 29340 25272 24681 81749 298947 24680 85243 366508 25493 58918 24185 84351 63879 116502 94193 309165 362100 83533 24887 54318 363855 25389 79255 315333 29414 305584 246756 24842 266610 311130 24835 170920 361795 360640 64547 246097 314322 25385 24888 54287 78963 25008 25402 114496 140926 116667 288753 25625 156767 246775 304962 293694 266704 116674 64026 64044 406169 81647 306886 60371 25309 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis 29592 64203 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway 287398 315994 81649 25096 289014 25097 60352 81757 116546 689314 289080 171455 29513 29622 501560 114495 304109 314436 308106 116554 303200 501099 116590 50658 29431 50689 29433 24516 29432 24703 64363 50686 65052 293621 25272 366957 298947 85243 363875 366508 170851 81504 58960 24605 114486 24356 24185 81771 85385 81745 25124 313845 25125 363855 84027 29414 24525 117273 64373 295342 116667 117269 81647 317203 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin 170851 58960 25679 81678 81666 25262 25238 314436 25372 24330 24179 24180 25387 25388 116590 50689 24703 64199 24400 85240 29322 24654 83579 690825 114119 58979 114117 294962 24680 60449 81667 245986 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation 316216 170844 361580 81674 316123 306516 303918 83503 498109 689030 294236 288651 361420 373541 309638 361365 306542 499766 366856 299347 288533 316711 81673 83828 307485 83830 171152 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway 311786 114851 24185 25233 81745 499417 690244 300126 299626 25112 297893 363067 25203 29414 291005 307511 25729 361724 24842 114212 54244 315713 246334 309757 25163 362675 313017 50557 54237 680054 314856 304798 685055 300711 362817 170915 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway 114120 309242 25031 24655 84587 140693 81666 114633 497197 81662 24400 116600 81802 25569 25023 25570 25653 25398 116700 25522 25297 257648 58942 85420 170538 29340 24681 81749 84006 25738 29337 24680 25012 83730 64630 116500 29528 25624 24803 50688 54234 85240 29322 24654 83579 690825 114119 58979 79218 114117 294962 60449 81667 245986 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis 79243 117182 25055 25322 286964 25147 266770 29540 81782 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway 312451 316527 83502 294732 29437 84426 161452 81822 307481 116782 360942 24697 307486 548105 191571 291646 680203 361943 291645 548106 307487 300128 307489 291654 291656 364844 394223 116779 116778 498843 393092 393091 295027 116742 93662 116781 393089 393088 393087 114028 311163 116741 116780 393086 291649 393085 83501 363948 317183 317204 301887 29181 84353 29163 84408 29162 25409 364841 307618 498850 311710 84407 291002 64865 306091 65048 83720 310174 117048 307614 361432 192248 114102 306081 498515 690865 301737 116808 252897 498849 680470 680361 364843 291635 502156 548104 360835 291637 83465 83466 498847 498846 553129 500047 317674 29275 287876 25365 79210 24882 58868 114487 303181 64558 316526 64566 315196 364754 266608 114850 282581 293990 291678 24881 64512 282582 116777 679869 303586 287357 289820 315294 116466 140584 UNTITLED%PANTHER PATHWAY%P06664 untitled 309165 114208 316742 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation 65029 29473 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle 170587 24368 360975 81530 114597 79250 685778 24551 117098 289217 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis 171374 116550 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation 24609 58961 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion 361465 24624 301276 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis 305348 PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism 58813 81632 362638 81656 65208 116593 81708 25418 25416 65135 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation 501157 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway 25636 24679 29699 114120 24611 24925 293508 501563 83579 690825 114119 81636 58979 79218 114117 294962 60449 24400 84420 81667 245986 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade 50557 314856 24855 304798 60445 84482 50686 294515 25151 81745 24483 25467 25718 24482 24506 24954 60663 29376 84027 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway 25636 24679 29699 114120 24611 293508 25461 501563 83579 690825 114119 81636 58979 79218 114117 294962 60449 24400 84420 81667 245986 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway 114120 24611 25645 83579 690825 114119 81636 58979 79218 114117 294962 60449 24400 84420 81667 245986 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism 83585 25095 58813 497811 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis 81522 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway 114120 309242 24611 81666 81662 24664 64680 58959 81648 83579 690825 114119 58979 79218 114117 294962 60449 24400 81667 245986 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway 171041 57027 81649 207122 60352 689314 286997 50688 29513 292788 58840 300802 29392 289231 192218 288227 116554 29192 81751 116590 54226 50658 50689 24239 116600 25023 25522 85420 170538 29340 25272 24681 81749 84006 54268 83589 83610 29716 114493 316226 24680 83611 29355 309159 171549 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis 24250 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo 114523 295382 60628 25311 58946 360272 311860 314903 83467 65047 24772 295342 366957 114524 363875 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis 191575 83782 85269 685679 315615 313560 497840 65156 24240 619580 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway 287398 81649 60352 689314 25233 29513 114495 308106 116554 303200 116590 25676 50658 50689 24703 313834 292658 314612 64363 363616 361632 289021 25023 25522 65052 293621 85420 170538 29340 25272 24681 81749 84006 366957 298947 171492 25738 303604 29337 24680 85243 363875 366508 170851 58960 84477 25597 24605 361388 85421 114858 114486 24185 85385 685611 25482 24329 29496 24337 25124 192126 313845 304893 25125 291610 306141 363855 24592 294981 365355 29414 29542 691997 288774 497931 367264 25126 24918 59323 362896 361568 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade 361969 25692 25619 85253 24617 171045 60325 287527 171052 300339 24366 81687 24367 PNAT%PANTHER PATHWAY%P05912 PNAT 29528 25624 24898 24803 293508 501563 304081 360616 81636 25686 81664 29553 64199 84429 84420 24400 25549 24679 25636 29699 25643 81802 25432 24318 24668 24669 293860 25195 309557 24316 59317 25740 313052 116724 114117 25012 294962 83730 60449 64630 81667 116500 245986 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway 54244 303024 361769 29499 361765 301516 89830 140589 25273 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway 85426 60422 50690 293508 501563 25521 25686 81664 64199 24400 24679 25636 29699 59320 50664 25643 50599 83579 690825 114119 365901 58979 29713 79218 25743 114117 116560 294962 363143 60449 81667 25111 245986 81645 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism 302972 289608 304860 297417 360518 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway 24517 81649 24518 500245 83711 680931 60352 29373 498299 689314 25667 313588 29513 25296 114208 315824 25644 85272 81507 29455 140590 59302 25671 313121 500311 116554 29357 25631 116590 50554 50658 59304 50689 29152 64549 24516 290921 25196 294503 29200 29530 64466 289316 25717 29591 81810 114490 303614 252834 245921 59328 367100 81516 85435 81809 293621 25453 252833 500305 79216 25272 79558 29381 29263 25366 25237 300054 25445 690516 365460 29454 83470 24605 54244 170915 361568 81647 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation 83580 289055 306761 116727 691992 25087 29243 24946 302470 171154 306608 25268 502858 81750 25259 25439 362248 260320 25584 25048 29251 24367 361969 25692 25619 85253 24366 685269 116669 29436 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway 24605 309242 81666 58918 24185 25233 81662 294515 83840 81745 25467 680149 25637 302415 313845 25578 25686 60664 81664 84027 29414 24400 497931 24600 25643 84482 83579 690825 24954 25513 365901 29741 294962 60449 85243 81667 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway 81636 25686 24400 25636 25432 24318 50686 24415 680149 25033 171044 54305 65032 64354 25689 29353 54241 54244 116561 83800 81668 25354 25555 117097 29290 25369 29316 29335 500131 25739 29256 64035 24701 24260 25370 170915 25229 29413 298400 53949 25623 690987 690825 170704 114119 114211 58979 192646 79218 64561 114117 678739 361377 85268 81667 314638 24174 245986 362165 24175 24448 362339 24173 310616 29412 114120 25601 81646 24176 140671 293508 24418 24414 24613 25521 64508 81664 84420 60448 24679 29699 25323 25075 24473 25643 25187 25324 29581 24611 29595 50599 24925 25461 64532 25645 25289 29241 305509 54223 60590 81672 24419 24417 295347 171337 84027 25195 24316 29713 25743 116560 25111 81645 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway 287398 81649 79114 313022 60352 25114 25022 84489 689314 316213 25233 29513 314850 114495 308106 116554 303200 116590 25676 50658 50689 24703 64363 363616 361632 289021 25023 25522 65052 293621 85420 170538 29340 25272 24681 81749 84006 116689 366957 298947 171492 25738 303604 29337 24680 85243 363875 366508 170851 58960 25597 24605 114858 24185 85385 313845 291610 306141 363855 294981 29414 29542 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis 25698 497840 59085 25611 24240 303563 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction 114120 685451 24717 81760 307401 680149 85257 85259 83686 307100 500418 140936 25343 29481 289878 24400 83579 690825 114119 58979 79218 114117 294962 363143 81667 245986 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis 29592 64203 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease 81649 25097 60352 24898 286997 314436 116554 116590 25578 50658 50689 29219 25729 291983 116728 25085 29676 362485 56010 313017 29753 85492 25576 65033 29647 56816 60466 29673 307309 29674 94198 117515 29668 29669 25272 29670 29671 29672 252939 81728 56011 293507 117549 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway 25679 81678 309242 25031 207122 85426 60422 81666 25262 81662 24412 24411 24410 24409 24408 64199 24400 25023 25522 24260 85420 25229 170538 29340 24681 81749 84006 83579 690825 114119 58979 79218 114117 294962 24680 60449 29355 81667 245986 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway 114120 25643 24613 83579 690825 114119 81636 58979 79218 29190 25686 114117 29237 81664 294962 60449 24400 84420 81667 245986 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication 89809 116468 288414 680511 64550 309762 117056 288003 59294 304528 289758 59102 360243 25737 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway 293829 24624 301276 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis 83782 85269 685679 315615 26956 171566 81643 301005 303179 191575 315150 289276 362720 365320 117544 299976 24184 301115 29223 295088 288259 58964 311833 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway 24384 289055 24705 25271 24873 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway 25679 25601 114120 81678 309242 25031 81666 25262 81662 24418 24414 24613 685451 24400 50664 25432 25023 24318 25398 25522 257648 85420 170538 29340 24681 81749 84006 24680 24415 60590 81672 24419 24417 54234 295347 680149 171337 25033 171044 54305 54241 116561 83800 361714 81668 301372 25354 170668 25555 81509 25245 29290 29434 25369 313874 29316 117273 313644 29335 60323 298859 29256 25195 24316 24260 25370 25229 85240 29322 53949 24654 690825 114119 58979 79218 114117 294962 60449 81667 25111 245986 81645 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis 89804 316527 89807 311332 24205 303811 306636 25186 25096 25097 362268 25233 25496 29492 406162 83805 25676 300955 25266 24628 25267 24629 363616 316369 84598 25439 84353 287398 315994 81649 79114 289014 24471 316213 314850 116554 116590 310688 29431 29433 50689 83785 24516 60664 29432 24703 170897 313834 292658 84574 24600 314612 29560 360820 64363 315189 361632 289021 25023 293783 24653 25522 65052 293621 85420 170538 29340 24681 287942 81749 54245 84006 298947 25513 29741 25738 29337 24680 85243 366508 170851 58960 308589 24605 85421 311193 114486 25420 300115 24356 58918 24185 25614 85385 25124 313845 25125 317674 84027 29414 58868 114487 314322 64566 315196 117273 290361 114850 84010 58844 64373 84427 312477 295342 25317 116667 24881 29146 64512 114125 282582 306760 114587 29210 79257 679869 691905 287989 79429 313633 315294 24338 116466 363595 299611 83721 691813 29147 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis 191575 83782 362720 29261 85269 365320 685679 301622 299976 315615 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking 25624 192177 25531 64830 24923 25558 25716 116470 60568 60565 191595 54309 25130 286931 59267 306285 25731 24805 25012 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 83502 501560 24330 25388 83805 246215 116490 25622 309168 79222 29304 24598 24854 24400 25298 25549 25706 25636 361882 50659 363854 25050 84382 114124 686059 29568 292887 367846 25668 84582 24790 24884 29527 25664 294235 64639 25320 25272 25433 81515 81504 24674 24514 25493 116636 83840 84353 499497 287398 117045 311658 81518 81646 81649 311245 24471 25262 114495 293508 314436 116554 501099 116590 81762 29431 50658 50689 24224 24516 24609 24703 292658 360820 64363 25023 24653 84482 85420 170538 29340 305509 81749 54245 25513 56011 25738 24680 85243 363875 170851 58960 85421 114486 24185 25614 81771 294515 85385 81745 25467 313845 25125 24887 304786 84027 25619 171045 360640 314322 117273 24888 25402 50646 296456 24511 81647 25414 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis 292804 25059 65152 24959 24333 24334 500983 24189 24651 296973 25630 24644 498731 25741 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway 362149 303101 311332 360801 362268 25496 29146 29492 114125 56761 114587 406162 29419 29147 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis 81632 24380 24379 60356 291133 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway 287398 299625 84359 298975 140657 58918 83584 300985 290027 60374 116685 25591 361046 297339 117279 296654 116554 50658 24516 266610 246097 25385 78963 25402 140926 25272 64026 64044 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway 360854 54227 288669 309452 24517 311716 309361 24518 301511 294732 29437 25233 81824 81822 81636 25686 25636 363616 25156 116669 24514 308875 171056 282832 360918 316019 292413 292409 288264 307820 245920 116637 81780 287561 24770 29397 311647 114098 287562 301086 24525 25542 363682 498806 29538 29605 298006 311570 60463 79433 117551 24582 57301 691644 84475 24583 29363 360543 89808 29556 301066 29557 85240 287673 252942 29322 308163 25745 24654 117029 308572 171054 366069 117027 114119 25400 58979 24246 79218 114117 60449 361400 305897 245986 25679 311658 114120 81678 309242 25031 24655 84587 140693 81666 114633 25262 497197 81662 293508 501563 296078 288057 116590 81762 29431 29433 50689 297518 24516 81664 29432 24703 311450 292756 50664 291926 64363 25643 29647 25023 117558 25522 64532 25289 29340 366957 298947 25712 25738 29337 85243 363875 366508 24605 60628 24185 84351 85385 81745 309165 116562 313845 25125 29385 29275 54258 287876 29414 25365 117273 295342 501132 361568 50646 308995 314981 25713 25683 24511 361821 294337 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway 83585 291355 290029 24465 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease 287398 192154 360854 360654 54227 29495 29430 308476 252902 29167 294732 116694 29437 679870 85428 294854 308463 29153 29154 29155 81824 29156 83685 207117 300078 81822 81917 116659 29564 303968 299145 29489 300047 308578 50658 81637 81655 24516 171495 84009 498736 29424 66020 29214 140734 408218 308666 306260 24225 246118 296554 24790 307351 291081 366957 500983 24407 363875 298521 54257 29559 24406 24412 24411 24410 308875 24409 24408 363855 29275 287876 25365 24842 54244 116561 246334 362675 314322 78963 25402 170915 501132 289820 64044 117526 58945 293539 65209 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation 246758 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism 170587 306198 685778 362282 25104 117098 24651 24159 24552 25630 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation 309361 25262 25233 116554 116590 50658 29431 50689 300955 29433 24516 60664 29432 24703 64363 366962 171378 81511 316369 25710 315609 65052 300678 293621 25300 85420 155918 301348 313050 25660 295378 25408 56822 298947 296603 25513 29741 24699 25738 25156 85243 363875 366508 170851 58960 24605 24674 114486 24675 25493 24185 84351 313845 29414 314322 116667 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway 300447 170851 58960 300177 301059 363984 81649 309361 680127 316241 311245 292892 25493 361677 317468 305355 314436 84351 313121 116554 303200 50658 50689 24516 252961 363520 305353 29260 364594 364867 310553 116596 299827 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism 293820 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway 691857 25671 50554 24400 59328 84353 24672 24673 140941 85240 29322 24654 114119 58979 79218 114117 294962 60449 361400 81667 305897 245986 25679 311658 114120 81678 309242 25031 81666 25262 81662 685451 500047 317674 79210 312781 24882 58868 293649 114487 303181 64558 316526 64566 315196 364754 266608 114850 282581 293990 291678 24881 64512 282582 116777 679869 79257 303586 287357 315294 116466 140584 83721 312451 316527 83502 303811 84426 161452 25387 25388 297893 307481 116782 360942 307486 548105 191571 291646 680203 361943 291645 548106 307487 300128 24674 307489 24675 291654 291656 364844 394223 116779 116778 498843 393092 393091 295027 116742 93662 116781 393089 393088 393087 116741 116780 393086 291649 393085 83501 363948 317183 54244 317204 301887 29181 29163 84408 29162 25409 364841 307618 498850 311710 84407 291002 64865 306091 65048 170915 83720 310174 117048 307614 361432 192248 114102 306081 498515 690865 116808 252897 498849 680470 680361 364843 291635 502156 548104 360835 291637 83465 83466 498847 498846 553129 25023 171378 25522 85420 170538 29340 24681 81749 84006 24680 361745 317575 171379 295568 140593 301020 361825 81650 307641 287102 302711 64823 65278 58822 64462 113927 500430 304569 84027 307505 297357 310707 307766 316477 500666 25539 685179 83833 363002 303518 296732 296084 361652 312754 309179 691318 363193 299147 114107 29748 29749 303024 171107 363481 365755 361765 497961 297867 84578 362533 299636 298019 25565 84424 295251 84577 294071 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway 24165 292072 497811 291355 290029 24465 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism 24538 25330 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway 29528 25624 24415 24923 24803 116470 50688 293508 54234 501563 25521 25686 81664 64199 24400 24679 25636 29699 59320 50664 25643 25398 257648 83579 690825 114119 365901 58979 79218 114117 25012 294962 83730 60449 64630 81667 116500 245986 UNTITLED%PANTHER PATHWAY%P05916 untitled 114120 50664 25643 29335 83579 690825 24221 114119 25504 81636 58979 79218 29190 25686 114117 81664 294962 60449 24400 84420 81667 245986 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins 25150 306790 65208 79209 246331 316009 117273 25416 25417 65135 29751 60323 361597 140908 25415 366957 29431 363875 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling 29717 50664 25643 25398 25248 257648 24418 24414 85240 29322 24654 690825 58979 79218 25686 114117 294962 64199 60449 24400 81667 245986 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I 316216 689030 499766 361420 690450 360893 25574 287710 304714 83582 140938 117526 680050 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides 362638 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway 25636 24679 29699 114120 24176 24611 293508 501563 83579 690825 114119 81636 58979 79218 114117 294962 60449 24400 84420 81667 245986 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release 25601 114120 81646 293508 24613 501563 81636 25686 81664 84420 24400 24679 25636 29699 50664 25643 24611 83579 690825 114119 58979 79218 29190 114117 29237 294962 60449 81667 245986 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis 25612 ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway 24173 29412 25031 114633 25262 81662 170538 29340 85240 24681 29322 24654 24680 24174 24175 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome 29270 24312 29224 24192 29498 171128 29244 64192 TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway 24715 24179 24310 ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate 361596 54702 50655 308457 25104 363061 308913 170943 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 361272 298942 79250 24479 81654 171087 170587 114096 114597 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders 25014 25244 296259 81632 29711 140547 301384 24624 298942 24158 29611 81708 85239 369018 314800 60581 293829 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway 29597 50646 24680 25738 25023 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway 24465 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway 24413 299331 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId 25634 24390 83782 289827 298003 246272 298410 24528 24778 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway 171369 84349 309361 140934 81649 311245 84351 362788 114856 309295 81736 25493 116667 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism 290651 363131 114558 80849 25031 81677 64161 116482 56718 316457 316376 85243 83523 171458 29390 307842 252899 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency 64524 24189 362706 29562 24362 83688 362383 24377 25741 292804 CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway 24715 24179 24310 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism 294793 690987 24645 24203 367562 289827 83472 24434 685076 362029 64035 292804 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) 25104 24192 685778 25014 289950 24651 311569 298942 24439 294320 307858 81654 29539 500965 299203 362282 60581 170570 24551 24552 680021 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II 25363 25757 25413 364975 25014 140547 24158 64304 170465 171155 170670 25287 25288 25618 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency 24250 689330 361286 24962 84350 680036 171347 287379 362657 81508 84596 290551 81640 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway 361523 29277 25375 29296 293985 24188 24424 286929 24299 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria 314196 301624 192268 361596 50655 25104 363061 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 24399 361272 298942 79250 24479 81654 171087 170587 114096 114597 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency 24434 50555 292804 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway 24680 25155 363875 313050 81504 81511 85385 116554 25738 314322 24703 314436 293621 24516 25513 116667 50663 363855 25150 170851 24674 309165 25023 81736 50689 25493 246781 29434 307820 50522 300678 25300 24675 25710 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway 29441 295923 170913 24565 497811 84014 171516 24314 362837 24600 78959 304078 289218 29224 312382 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 289827 286954 83472 24434 497039 685076 362029 64035 25059 24385 292804 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling 25612 29172 309312 29301 497840 24399 192268 25044 246307 298942 306586 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn 29253 25375 24401 81683 56823 25699 308800 24267 290484 29383 360719 24311 65029 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages 170851 25262 24680 24654 309165 25023 81736 50689 25493 29716 114493 116590 24239 24703 293621 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway 24506 25398 25351 300992 50688 25559 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor 81666 25262 24680 24654 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism 297417 363103 300757 289032 298071 304860 81759 498486 302972 363109 311530 312826 114711 498272 297393 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism 65052 363131 114558 24654 366508 50557 85238 116723 309855 64161 24329 59319 192260 316457 361632 24337 54259 25513 307842 116699 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 24189 24362 24333 25059 292804 500983 25634 498731 24959 313843 171087 64201 362282 81829 171053 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency 24189 24362 83688 362383 292804 24377 64524 362706 290636 24645 298954 501157 25741 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis 81640 689330 24609 171347 84596 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism 24715 24179 24310 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency 25104 363061 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 361272 298942 79250 81654 171087 170587 114096 24551 114597 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation 24439 294320 307858 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria 24189 24788 25659 291095 24192 501167 24362 246232 300089 498731 24638 300741 25741 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway 365320 299976 29261 313560 140944 63997 116642 79127 298410 191575 290741 362720 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 29277 116649 619380 29296 24925 29712 24239 286929 29715 689421 65195 59324 25471 300992 50688 24297 574523 286906 287164 360734 396552 116598 24314 24861 64367 680945 192235 117030 25617 25315 113992 24267 25086 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency 24333 685529 361042 292804 24240 303565 498731 296973 24190 313843 171087 66020 171147 114508 81829 171053 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis 25634 24390 83782 289827 298003 246272 298410 24528 24778 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism 65156 83585 362720 24240 299976 499956 29261 311422 295620 313560 362638 314004 26956 315219 246272 65135 81656 290741 116593 58964 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) 113965 63864 314800 25014 64304 170465 140547 25287 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway 574523 361523 83783 498198 396552 24890 84493 25256 286929 171522 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 499374 362631 81764 290868 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway 170913 24565 680876 24842 84014 316231 140668 114851 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency 498198 24188 286929 24299 266686 246298 114106 690953 170635 84497 313689 64047 361523 286906 116676 287164 252931 360734 171352 314264 116598 363471 24861 299511 64367 362757 680945 89826 192235 679520 117030 154985 25617 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I 24598 64313 497840 24399 306574 680409 25611 81660 24264 25257 364064 29221 24401 25698 361612 59085 114027 289352 297969 29408 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease 114209 65183 84356 363516 65192 85255 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency 24250 689330 361286 24962 84350 680036 171347 287379 362657 81508 84596 290551 81640 FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway 24715 24179 24310 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency 65156 83585 362720 24240 299976 499956 29261 311422 295620 313560 362638 314004 26956 315219 246272 65135 81656 290741 116593 58964 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis 308800 290484 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism 29531 301544 288917 24616 24401 313047 29383 360719 24813 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria 113965 364975 25014 299201 140547 361272 298942 64554 29416 291640 291450 303272 296925 DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency 65152 362706 24190 501157 114508 64390 298655 83688 689374 362383 292804 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome 24189 25634 500983 65152 498731 24959 313843 24333 25059 24651 292804 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary 24189 24788 25659 291095 24192 501167 24362 246232 300089 498731 24638 300741 25741 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway 286929 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway 24715 24179 24310 INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone 24400 114120 116700 25449 81646 24668 293508 680149 81636 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency 25085 24311 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism 293779 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 24189 25104 24362 24333 25059 294088 292804 29573 25634 500983 498731 24645 296973 24959 313843 171087 500965 64201 362282 25351 81829 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle 25240 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism 83523 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) 29653 303698 60666 114101 366196 306582 29390 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency 24189 24362 24333 25059 292804 500983 25634 498731 24959 313843 171087 64201 362282 81829 171053 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway 361523 396552 24904 286929 286989 171522 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms 60447 24603 287422 58822 299691 CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency 24598 64313 497840 24399 306574 680409 25611 81660 24264 25257 364064 29221 24401 25698 361612 59085 114027 289352 297969 29408 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway 24680 25155 499356 363875 313050 81504 85385 116554 25738 314322 24703 314436 293621 24516 81515 116667 50663 170851 24674 25023 50689 307820 24675 171055 304496 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB 24189 25104 24362 24333 25059 294088 292804 29573 25634 500983 498731 24645 296973 24959 313843 171087 500965 64201 362282 25351 81829 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins 25229 24400 25187 81666 24654 680149 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 289352 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway 24400 81666 24715 24180 24179 24310 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 499374 362631 81764 81765 296644 25347 680395 301544 81774 288917 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway 24715 24179 24310 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease 24189 24644 24333 25059 24651 292804 25634 500983 65152 296973 24959 313843 25351 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway 83783 171522 24912 25086 25260 24426 286929 116721 24299 170924 83808 25355 312382 24297 286906 170913 287164 24565 360734 396552 116598 24861 64367 680945 192235 117030 25617 113992 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation 29611 25244 29711 301276 25044 298942 24624 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 89833 24312 680308 300886 361472 303333 362657 315763 64300 25455 CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway 171522 29277 293985 25086 290623 286929 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 396552 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 292023 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism 24962 287379 25044 306586 81660 298942 24792 245961 25257 303306 309312 293820 29253 29539 25134 304429 297113 114123 299857 266975 366959 58835 FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway 170913 24565 680876 24842 84014 316231 140668 114851 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 29692 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria 29253 25375 24401 81683 56823 25699 308800 24267 290484 29383 360719 24311 65029 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain 26195 171374 25309 363061 171082 116550 301011 363441 85333 298596 26197 157074 65262 289217 29573 500983 245965 171375 25062 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism 81716 309004 24314 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway 29686 29571 286929 24297 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency 25055 192242 307092 252898 309527 25541 25429 301517 81924 25428 79244 25284 29725 79111 362782 246211 301264 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism 288240 116719 306262 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency 25721 29221 25698 59085 497840 24399 192268 306574 81670 25611 305540 292657 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway 24715 24179 24310 OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism 25634 24390 114860 24645 116569 316033 289827 367562 363494 24192 298003 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway 25375 25086 286929 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism 500709 306808 64473 290651 499084 80849 81677 83523 171458 116699 294292 50560 171088 BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism 113965 79238 25014 64304 690163 140547 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle 25104 363061 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 361272 298942 79250 81654 171087 170587 114096 24551 114597 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome 297417 25721 117544 24379 29739 685245 25283 25458 81632 116686 497840 24399 290868 291133 24240 498486 29408 192268 295088 81670 297393 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 24333 685529 361042 292804 24240 303565 498731 296973 24190 313843 171087 66020 171147 114508 81829 171053 MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway 310645 89784 25014 81681 29580 81726 25675 83791 29637 29230 BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I 500983 498731 25630 60416 292804 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency 64524 24189 362706 29562 24362 83688 362383 24377 25741 292804 PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis 192260 64369 681361 298579 29653 303698 287644 60666 81925 25097 366196 406165 293620 25514 29194 140544 361401 314553 29390 290567 140866 25062 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency 25104 363061 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 361272 298942 79250 81654 171087 170587 114096 24551 114597 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway 362119 294257 299314 24232 24237 54249 117517 298288 117512 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway 29277 498198 29296 286929 171522 25553 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism 363494 361213 85496 83626 366697 305684 313536 308589 313339 297805 300129 314438 50555 HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) 29270 24312 29224 24192 29498 171128 29244 64192 CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis 24333 685529 361042 292804 24240 303565 498731 296973 24190 313843 171087 66020 171147 114508 81829 171053 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency 24189 24362 24333 25059 292804 500983 25634 498731 24959 313843 171087 64201 362282 81829 171053 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides 298182 25352 24787 24786 24248 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway 286906 170913 287164 24565 360734 498198 396552 116598 24861 64367 680945 192235 117030 25617 113902 65036 286929 64550 498940 312382 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway 24400 81666 24715 24180 24179 24310 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 304917 29243 25048 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway 24715 24179 24310 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect 83688 362383 24159 298655 64831 689374 316265 361071 360975 50655 311254 363061 24191 25630 24368 25179 298596 157074 24333 289217 116686 29711 24399 24398 292804 24240 25027 65152 296973 24479 171087 66020 170587 114096 171147 24551 PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway 286929 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway 170913 24565 680876 24842 84014 316231 140668 286929 114851 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway 170851 24954 252971 24680 313845 25139 24514 81504 81771 85385 50689 24506 24918 116689 25235 25467 25126 116590 25738 24703 293621 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct 25390 54302 29639 24211 25386 312488 24779 24768 24212 65133 25122 24767 24715 24213 29132 25650 310218 24214 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle 500983 60666 25062 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia 29270 24312 29224 24192 29498 171128 29244 64192 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency 25104 363061 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 361272 298942 79250 81654 171087 170587 114096 24551 114597 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome 25104 24192 685778 25014 289950 24651 311569 298942 24439 294320 307858 81654 29539 500965 299203 362282 60581 170570 24551 24552 680021 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL 84477 313845 83571 24888 287942 56718 24514 81504 54245 83840 64639 294790 500985 24918 314856 24577 24842 25513 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism 65052 114633 309008 363131 65038 366508 499508 311647 29390 307842 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) 313121 29431 25591 362456 64044 25402 114214 24708 64026 287398 498331 29432 299625 84359 246097 64159 25385 362491 140657 116554 24516 116667 140926 83584 360748 60374 116685 266610 117279 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway 170913 24565 58978 680876 312382 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I 24792 25104 171087 301254 81670 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency 29270 24312 29224 24192 29498 171128 29244 64192 GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle 498731 501157 362383 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway 432361 24680 59323 29496 57027 29192 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway 24715 24179 24310 FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 304917 29243 25048 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway 29509 29277 293985 286954 29296 396527 25086 83500 290623 286929 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 286906 299732 287164 287454 360734 286904 396552 171516 116598 59103 24861 25526 64367 25290 680945 287425 192235 24886 117030 81639 25617 266604 24693 29527 29224 286989 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule 84551 29509 25550 113918 29503 83509 307811 50567 50719 25240 116726 29484 84484 24782 310218 170573 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway 170851 313845 24514 81504 85385 50689 24918 116689 116554 25738 24703 314322 314436 24335 293621 24336 24516 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway 25601 286929 286989 171522 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway 24310 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway 64524 29562 290636 24645 24190 501157 24362 362383 25741 292804 24377 HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development 114109 501099 54254 171160 GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism 81641 408206 362368 29739 64026 25283 24404 25458 116686 309465 116684 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease 314360 316033 353229 363494 499210 315222 361213 117185 360833 286896 83626 366697 65196 301543 303729 308589 301118 64369 300129 314438 50555 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency 81708 29539 24379 81632 65135 29473 81656 307212 116593 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell 81666 24680 24654 24260 25559 252857 24803 24400 25679 25531 60341 25051 25398 59320 25351 300992 50688 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin 24400 64354 81646 24668 293508 680149 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway 361523 25601 171352 29296 293985 24409 24408 286929 171522 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism 24250 689330 24962 308993 29443 295455 171347 290564 363285 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease 25623 25059 292804 24645 289827 83472 24434 497039 685076 362029 64035 24385 288333 501907 497756 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 63889 24400 293508 680149 81636 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway 24310 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism 690987 289632 293721 288333 292804 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria 29531 301544 288917 24616 24401 313047 29383 360719 24813 FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling 24185 24400 25262 81762 305509 302378 24654 501099 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria 297417 363103 300757 289032 298071 304860 81759 498486 302972 363109 311530 312826 114711 498272 297393 ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism 680668 305889 289175 361443 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH 25117 25116 24298 192242 24294 307092 353498 29680 25146 360348 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency 25413 288369 117035 83842 311849 305581 64460 84356 363516 25288 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease 314360 316033 353229 363494 499210 315222 361213 117185 360833 286896 83626 366697 65196 301543 303729 308589 301118 64369 300129 314438 50555 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency 24950 117182 192242 25322 25355 25147 292915 501907 266685 25146 24800 ARGININEMIA%PATHWHIZ%PW000183 Argininemia 25721 29221 25698 59085 497840 24399 192268 306574 81670 25611 305540 292657 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease 24240 25612 79251 685325 291556 116483 25698 24379 315150 59085 81632 246307 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages 50689 170851 25493 25262 24680 116590 24654 24703 293621 309165 25023 81736 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway 298079 296259 311569 29253 29539 25375 24401 81683 25086 56823 24248 25699 308800 24267 290484 29383 360719 24311 65029 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 170851 24680 25139 24514 24391 81504 81771 85385 50689 24506 24918 116689 25235 25467 116590 25126 25738 24703 293621 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism 24792 25104 171087 301254 81670 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency 25014 25244 296259 81632 29711 140547 301384 24624 298942 24158 29611 81708 85239 369018 314800 60581 293829 CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis 25104 363061 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 361272 298942 79250 81654 171087 170587 114096 24551 114597 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III 114860 24645 289827 287835 83472 246232 298003 24385 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway 24185 24680 25738 25156 24654 298947 497932 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging 24314 300807 60447 83516 24603 289095 309757 297508 298653 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease 29421 289219 25709 309070 304024 24451 291470 25374 314323 361338 24434 309391 116599 501907 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin 24400 81646 24668 65032 293508 680149 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway 24413 299331 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle 25721 29221 25698 59085 497840 24399 192268 306574 81670 25611 305540 292657 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 24189 25104 24362 24333 25059 294088 292804 29573 25634 500983 498731 24645 296973 24959 313843 171087 500965 64201 362282 25351 81829 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway 286906 287164 360734 29509 396552 116598 24861 64367 680945 192235 117030 25617 24693 29527 29277 293985 286954 29296 396527 83500 286929 286989 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis 500983 498731 24959 313843 25630 299052 24333 60416 24778 292804 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway 29296 286929 171522 83511 25553 24297 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 293508 690848 24679 294560 84396 25521 29699 24782 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 171522 29571 619380 29296 25398 286929 300992 50688 24297 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway 574523 25590 361523 25101 396552 84493 54349 24299 54239 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis 64040 64564 689954 170898 287379 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency 29653 60666 25375 406165 24192 24539 24538 246115 25062 64369 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy 25363 25757 25413 364975 25014 140547 24158 64304 170465 171155 170670 25287 25288 25618 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis 84477 313845 83571 24888 287942 56718 24514 81504 54245 83840 64639 294790 500985 24918 314856 24577 24842 25513 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism 297417 25721 117544 24379 29739 685245 25283 25458 81632 116686 497840 24399 290868 291133 24240 498486 29408 192268 295088 81670 297393 XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 25623 25059 292804 24645 289827 83472 24434 497039 685076 362029 64035 24385 288333 501907 497756 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway 24627 361274 117544 25028 81643 292072 362329 303179 117533 363875 289276 65194 25202 691960 297998 690050 314312 25368 83585 297389 362720 365320 287420 290029 613267 116484 66012 116721 140944 170924 63997 497811 54349 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I 25363 25757 25413 364975 25014 140547 24158 64304 170465 171155 170670 25287 25288 25618 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I 113965 364975 25014 299201 140547 361272 298942 64554 29416 291640 291450 303272 296925 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway 83782 191575 24184 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency 25117 25116 24298 192242 24294 307092 353498 29680 25146 360348 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway 24627 361274 117544 25028 81643 292072 362329 303179 117533 363875 289276 65194 25202 691960 297998 690050 314312 25368 83585 297389 362720 365320 287420 290029 613267 116484 66012 116721 140944 170924 63997 497811 54349 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism 287478 293638 192172 24401 500965 29739 24962 25283 81718 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway 24680 287398 81504 85385 288774 116554 25124 84598 25738 25313 362896 116549 24703 314322 314436 293621 501099 24516 25125 116667 25676 170851 313845 24329 25023 50689 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism 89833 24312 680308 300886 361472 303333 362657 315763 64300 25455 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation 24189 24788 25659 291095 24192 501167 24362 246232 300089 498731 24638 300741 25741 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) 24250 24962 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism 25586 54349 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism 114860 24645 289827 83472 296117 246232 298003 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway 24715 24179 24310 PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency 81641 408206 362368 29739 64026 25283 24404 25458 116686 309465 116684 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway 113902 29261 362638 116642 315219 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism 308800 85496 501601 24161 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 286954 396527 25398 83808 300992 50688 286906 287164 360734 396552 116598 24861 24409 64367 24408 680945 192235 117030 25617 286989 24213 24898 29132 83511 24664 25650 25553 24214 54239 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids 113965 63864 314800 25014 64304 170465 140547 25287 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) 25721 29221 25698 59085 497840 24399 192268 306574 81670 25611 305540 292657 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism 25363 25757 25413 364975 25014 140547 24158 64304 170465 171155 170670 25287 25288 25618 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis 406165 84470 310773 64369 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency 83783 64473 81805 292915 294103 314694 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I 25363 25757 25413 364975 25014 140547 24158 64304 170465 171155 170670 25287 25288 25618 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway 24715 24179 24310 CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway 25461 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway 29277 396552 286929 171522 24693 29527 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway 83782 191575 24184 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation 25552 25390 60576 29639 24211 25351 24212 24213 29132 24385 25650 24214 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism 25104 24192 685778 25014 289950 24651 311569 298942 24439 294320 307858 81654 29539 500965 299203 362282 60581 170570 24551 24552 680021 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II 24598 64313 497840 24399 306574 680409 25611 81660 24264 25257 364064 29221 24401 25698 361612 59085 114027 289352 297969 29408 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway 25750 29253 171352 29296 54349 171522 25553 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria 113965 364975 25014 299201 140547 361272 298942 64554 29416 291640 291450 303272 296925 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle 309111 307759 25351 25139 24399 81670 305540 170573 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway 365320 299976 29261 313560 140944 63997 116642 79127 298410 191575 290741 362720 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect 83688 362383 24377 64524 25351 192268 25741 292657 50655 25104 363061 25630 94173 25179 24368 24644 362404 298596 685778 299201 157074 289950 24333 289217 25059 24399 361272 24651 292804 298942 500983 79250 25027 290636 24959 24479 24190 81654 171087 500965 170587 114096 24551 114597 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway 24310 TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease 297417 363103 300757 289032 298071 304860 81759 498486 302972 363109 311530 312826 114711 498272 297393 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL 84477 313845 83571 24888 287942 56718 24514 81504 54245 83840 64639 294790 500985 24918 314856 24577 24842 25513 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect 83688 362383 24377 192268 50655 25104 25630 94173 117098 24368 24644 295356 362404 298596 29482 290685 157074 289950 24333 24399 25059 361272 60416 292804 298942 500983 79250 24479 81654 170587 171087 114096 24551 114597 299052 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia 24250 689330 361286 24962 84350 680036 171347 287379 362657 81508 84596 290551 81640 G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease 297417 363103 300757 289032 298071 304860 81759 498486 302972 363109 311530 312826 114711 498272 297393 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) 140910 114100 309262 89789 25427 64191 29540 117278 298298 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism 24598 64313 497840 24399 306574 680409 25611 81660 24264 25257 364064 29221 24401 25698 361612 59085 114027 289352 297969 29408 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway 84598 116590 56718 25125 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway 25601 113902 65036 498940 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism 65052 290651 114558 85238 295230 83523 25031 312952 171458 29390 307842 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway 170851 24185 25309 25096 309361 84014 363875 24888 78963 295378 117273 58918 64639 81757 50689 302415 29622 25631 50554 24703 314436 293621 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis 24400 24298 81666 24180 24294 29680 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency 24189 24362 83688 362383 292804 24377 64524 362706 290636 24645 298954 501157 25741 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis 25085 24311 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway 170913 24329 312382 NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria 287478 293638 192172 24401 500965 29739 24962 25283 81718 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway 685269 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway 24310 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling 24185 24400 25262 81762 305509 500317 24654 501099 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway 361523 29277 25375 498198 293985 24188 286929 24299 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) 25051 338443 29500 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling 170851 24185 58960 24954 313845 298947 25139 497932 81504 85385 24506 25467 116554 116590 24703 84482 29376 293621 81745 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency 25104 24192 685778 25014 289950 24651 311569 298942 24439 294320 307858 81654 29539 500965 299203 362282 60581 170570 24551 24552 680021 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 291624 81775 124323 296709 362041 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism 290651 85238 83523 312952 171458 311355 294292 50560 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid 24551 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked 25413 288369 117035 83842 311849 305581 64460 84356 363516 25288 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism 65052 363131 114558 85238 83523 307842 140693 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) 24962 287379 25044 306586 81660 298942 24792 245961 25257 303306 309312 293820 29253 29539 25134 304429 297113 114123 299857 266975 366959 58835 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease 24333 685529 361042 292804 24240 303565 498731 296973 24190 313843 171087 66020 171147 114508 81829 171053 TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway 685269 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency 81641 408206 362368 29739 64026 25283 24404 25458 116686 309465 116684 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway 64803 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) 25055 192242 307092 252898 309527 25541 25429 301517 81924 25428 79244 25284 29725 79111 362782 246211 301264 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System 24316 293508 81636 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway 361523 171352 498198 29296 293985 286929 25315 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway 25203 24224 362817 54237 25729 399489 299626 24708 58919 25737 24887 94201 78963 114851 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency 289827 286954 83472 24434 497039 685076 362029 64035 25059 24385 292804 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway 362119 294257 24232 24237 54249 117517 295703 24233 298566 29687 362634 312705 192262 24231 64668 64459 298288 117512 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway 25581 29677 117262 81827 29668 29669 29670 29671 29672 365388 29168 83499 314432 29675 29676 58854 29425 29666 85492 289990 29673 29674 94198 117263 50522 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura 29653 60666 25375 406165 24192 24539 24538 246115 25062 64369 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway 25262 24680 24654 81504 116554 116590 24703 314436 59323 293621 24516 116667 50663 363855 63836 25194 170851 81668 25096 81662 81686 64532 25400 116700 81707 25447 25329 83805 79255 25023 24330 117284 64465 25433 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism 29277 497811 293985 25086 286929 24299 116631 24297 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 171522 29571 619380 25398 286929 300992 50688 24409 24408 286989 24213 24898 29132 83511 24664 25650 25553 24214 54239 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial 113965 364975 25014 299201 140547 361272 298942 64554 29416 291640 291450 303272 296925 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency 25117 25116 24298 192242 24294 307092 353498 29680 25146 360348 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary 24189 24788 25659 291095 24192 24362 300089 307848 296571 300036 498731 310935 363145 24190 24638 300741 25741 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis 500983 25630 24333 299052 25059 60416 292804 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway 24680 25155 499356 363875 81504 85385 116554 25738 24703 314322 314436 293621 24516 81515 116667 170851 313845 25156 24674 25023 50689 367901 681236 361400 305897 311658 24675 171378 171055 304496 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling 24185 24400 25262 81762 305509 24654 116744 501099 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC 24189 25104 24362 24333 25059 294088 292804 29573 25634 500983 498731 24645 296973 24959 313843 171087 500965 64201 362282 25351 81829 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism 79238 25014 690163 117099 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism 24240 25612 79251 685325 291556 116483 25698 24379 315150 59085 81632 246307 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL 84477 313845 83571 24888 287942 56718 24514 81504 54245 83840 64639 294790 500985 24918 314856 24577 24842 25513 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway 498198 286929 303413 360243 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis 681361 29194 140544 310773 89841 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) 24598 64313 497840 24399 306574 680409 25611 81660 24264 25257 364064 29221 24401 25698 361612 59085 114027 289352 297969 29408 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism 500709 290651 363131 499084 114558 24655 295230 81677 64161 116482 59319 316376 83523 29390 307842 252899 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis 362100 24240 25402 114214 64026 360243 29395 680054 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis 24189 24362 24333 25059 292804 500983 25634 498731 24959 313843 171087 64201 362282 81829 171053 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway 685269 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA 25521 29699 24400 25636 59320 293508 680149 24679 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis 24189 25104 24362 24333 25059 294088 292804 29573 25634 500983 498731 24645 296973 24959 313843 171087 500965 64201 362282 25351 81829 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome 25055 192242 307092 252898 309527 25541 25429 301517 81924 25428 79244 25284 29725 79111 362782 246211 301264 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 292028 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway 362706 24645 29562 501157 24362 290685 299052 83688 60416 362383 292804 24377 TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I 29253 25375 24401 81683 56823 25699 308800 24267 290484 29383 360719 24311 65029 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency 25623 25059 292804 24645 289827 83472 24434 497039 685076 362029 64035 24385 288333 501907 497756 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome 24434 50555 292804 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway 362119 24232 24237 117517 24233 298566 29687 362634 312705 192262 24231 298288 117512 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease 24189 25104 24362 24333 25059 294088 292804 29573 25634 500983 498731 24645 296973 24959 313843 171087 500965 64201 362282 25351 81829 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis 500983 25634 498731 65152 24959 296973 25630 313843 24190 25351 24333 292804 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism 24189 24640 24788 24362 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway 24506 25398 25351 300992 50688 25559 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism 24434 50555 292804 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism 290029 310378 293504 353255 300691 499330 85496 54349 81506 367323 289095 297508 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism 29253 25375 24401 81683 56823 25699 308800 24267 290484 29383 360719 24311 65029 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria 29421 289219 25709 309070 304024 24451 291470 25374 314323 361338 24434 309391 116599 501907 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) 29421 289219 25709 309070 304024 24451 291470 25374 314323 361338 24434 309391 116599 501907 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway 24310 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism 24788 24640 292804 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway 286906 170913 287164 360734 498198 116598 24861 64367 680945 192235 117030 25617 24693 29527 140668 286929 303413 360243 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL 170913 84477 313845 83571 24888 287942 56718 24514 81504 54245 83840 64639 294790 500985 24918 314856 24577 24842 24904 25513 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease 297417 363103 300757 289032 298071 304860 81759 498486 302972 363109 311530 312826 114711 498272 297393 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II 24598 64313 497840 24399 306574 680409 25611 81660 24264 25257 364064 29221 24401 25698 361612 59085 114027 289352 297969 29408 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism 690654 246281 64206 59113 314442 24848 25120 116682 171385 29539 368066 24296 66029 56823 29416 24248 24311 LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation 363061 309361 311245 298596 84351 157074 309295 289217 309165 60416 81736 25493 170587 60350 60581 680127 24551 24552 29260 29743 301059 24159 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic 24962 287379 25044 306586 81660 298942 24792 245961 25257 303306 309312 293820 29253 29539 25134 304429 297113 114123 299857 266975 366959 58835 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) 25117 25116 24298 192242 24294 307092 353498 29680 25146 360348 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis 24400 114120 25449 25108 293508 680149 81636 COAGULATION%SMPDB%SMP0000586 Coagulation 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation 29539 298079 25086 24248 296259 311569 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism 289827 286954 83472 24434 497039 685076 362029 64035 25059 24385 292804 GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency 29653 60666 25375 406165 24192 24539 24538 246115 25062 64369 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 297113 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia 25634 24390 114860 24645 116569 316033 289827 367562 363494 24192 298003 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) 140910 114100 309262 89789 25427 64191 29540 117278 298298 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) 29531 301544 288917 24616 24401 313047 29383 360719 24813 VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway 170913 24565 58978 680876 312382 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency 29270 24312 29224 24192 29498 171128 29244 64192 HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) 25117 25116 24298 192242 24294 307092 353498 29680 25146 360348 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) 24842 24314 289095 309757 25668 297508 361843 298653 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway 24400 81666 24715 24180 24179 24310 GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer 83509 24159 192268 192208 305540 361596 292657 25721 25104 363061 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 24399 361272 298942 79250 25027 81654 171087 500965 170587 114096 24552 114597 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis 498731 501157 362383 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle 79430 25390 29639 24715 24211 24212 24213 29132 691209 25650 24214 25065 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway 89833 24312 680308 300886 361472 303333 362657 315763 64300 25455 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 25623 25059 292804 24645 289827 83472 24434 497039 685076 362029 64035 24385 288333 501907 497756 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I 25721 29221 25698 59085 497840 24399 192268 306574 81670 25611 305540 292657 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 24250 689330 361286 24962 84350 680036 171347 287379 362657 81508 84596 290551 81640 RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway 24216 24217 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 289352 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency 25085 24311 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency 289827 286954 83472 24434 497039 685076 362029 64035 25059 24385 292804 ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) 24598 64313 497840 24399 306574 680409 25611 81660 24264 25257 364064 29221 24401 25698 361612 59085 114027 289352 297969 29408 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway 25614 170851 25414 50646 116720 81666 24772 60628 25686 680149 54245 81736 50689 25493 24400 116590 25738 24703 293621 360820 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) 24598 64313 497840 24399 306574 680409 25611 81660 24264 25257 364064 29221 24401 25698 361612 59085 114027 289352 297969 29408 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) 25363 25757 25413 364975 25014 140547 24158 64304 170465 171155 170670 25287 25288 25618 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome 289827 286954 83472 24434 497039 685076 362029 64035 25059 24385 292804 SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway 24310 FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway 24715 24180 24179 24310 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 171522 29571 619380 29296 25398 300992 50688 25750 171352 24409 24408 54349 29253 24213 24898 29132 83511 24664 25650 25553 24214 54239 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) 297417 25721 117544 24379 29739 685245 25283 25458 81632 116686 497840 24399 290868 291133 24240 498486 29408 192268 295088 81670 297393 WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary 65152 498731 24191 24190 114508 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 286929 29715 689421 65195 59324 25471 300992 50688 24297 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II 25055 192242 307092 252898 309527 25541 25429 301517 81924 25428 79244 25284 29725 79111 362782 246211 301264 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway 24400 81666 24715 24180 24179 24310 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia 24792 25104 171087 301254 81670 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling 309361 81649 306886 252961 64314 84351 287398 303200 309295 314756 24835 246756 311786 293694 315305 81736 114495 25493 116554 24516 116667 363855 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation 114209 65183 84356 363516 65192 85255 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway 24185 24680 25738 24654 497932 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome 25623 25059 292804 24645 289827 83472 24434 497039 685076 362029 64035 24385 288333 501907 497756 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids 25757 113965 25413 117035 170465 171155 170670 140547 25287 25288 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 59268 94267 290651 80849 81677 83523 171458 311355 316376 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis 25104 24362 24333 292804 500983 25634 498731 24959 296973 360511 24645 313843 24190 171087 64201 362282 25351 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures 113965 364975 25014 299201 140547 361272 298942 64554 29416 291640 291450 303272 296925 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway 25590 25390 65180 29639 25601 25101 24316 29686 24211 24473 84493 29412 25121 24212 29571 619380 25398 24299 300992 50688 574523 361523 396552 24409 24408 54349 24213 24898 29132 83511 24664 25650 25553 24214 54239 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) 29421 289219 25709 309070 304024 24451 291470 25374 314323 361338 24434 309391 116599 501907 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 24333 685529 361042 292804 24240 303565 498731 296973 24190 313843 171087 66020 171147 114508 81829 171053 GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy 314360 316033 353229 363494 499210 315222 361213 117185 360833 286896 83626 366697 65196 301543 303729 308589 301118 64369 300129 314438 50555 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism 89833 29301 307212 24443 29253 29539 685999 25375 81676 291394 293871 89820 307492 299735 65029 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 306804 29304 81775 124323 296709 362041 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle 25721 64201 81829 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) 65156 83585 362720 24240 299976 499956 29261 311422 295620 313560 362638 314004 26956 315219 246272 65135 81656 290741 116593 58964 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway 245961 25134 689330 114123 299857 291450 171347 287379 85254 81508 81522 290551 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway 362119 24231 24232 64668 24237 64459 117517 24233 298288 117512 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis 60581 CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway 113902 29261 362638 116642 315219 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency 24598 64313 497840 24399 306574 680409 25611 81660 24264 25257 364064 29221 24401 25698 361612 59085 114027 289352 297969 29408 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 287191 296709 362041 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism 81708 29539 24379 81632 65135 29473 81656 307212 116593 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway 498198 286929 303413 360243 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria 25104 171087 64201 24551 685778 24552 289950 24159 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway 361523 170913 29277 498198 29296 286929 64803 24297 84024 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway 24506 25398 25351 300992 50688 25559 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency 297417 25721 117544 24379 29739 685245 25283 25458 81632 116686 497840 24399 290868 291133 24240 498486 29408 192268 295088 81670 297393 ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29412 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) 29470 29411 63864 170465 171155 170670 140547 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency 65156 83585 362720 24240 299976 499956 29261 311422 295620 313560 362638 314004 26956 315219 246272 65135 81656 290741 116593 58964 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells 155918 24497 116551 24680 24653 81649 25155 363875 287398 24835 25047 81504 81511 116553 116630 54259 116554 116590 25738 24605 24703 287287 293621 25316 81515 25513 24525 363855 25150 170851 24185 58960 84477 313845 303200 295378 114495 367901 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis 25117 25116 24298 192242 24294 307092 353498 29680 25146 360348 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency 24250 689330 361286 24962 84350 680036 171347 287379 362657 81508 84596 290551 81640 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway 65152 362706 24190 501157 114508 64390 298655 83688 689374 362383 292804 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria 314196 192268 361596 50655 25104 363061 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 24399 361272 298942 79250 24479 81654 171087 170587 114096 114597 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway 24689 24362 290685 83688 362383 60416 24377 292804 362706 290636 24645 501157 299052 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation 50689 116590 24680 24654 24600 84351 81646 309295 81736 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism 24250 689330 361286 24962 84350 680036 171347 287379 362657 81508 84596 290551 81640 PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway 24329 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form 288240 116719 306262 LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway 24216 24217 NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia 24240 25612 79251 685325 291556 116483 25698 24379 315150 59085 81632 246307 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) 25117 25116 24298 192242 24294 307092 353498 29680 25146 360348 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency 24962 287379 25044 306586 81660 298942 24792 245961 25257 303306 309312 293820 29253 29539 25134 304429 297113 114123 299857 266975 366959 58835 ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism 408206 24379 309732 60356 81718 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III 25055 192242 307092 252898 309527 25541 25429 301517 81924 25428 79244 25284 29725 79111 362782 246211 301264 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway 24627 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] 24598 64313 497840 24399 306574 680409 25611 81660 24264 25257 364064 29221 24401 25698 361612 59085 114027 289352 297969 29408 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway 24329 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway 24627 361274 117544 25028 81643 292072 362329 303179 117533 363875 289276 65194 25202 691960 297998 690050 314312 25368 83585 297389 362720 365320 287420 290029 613267 116484 66012 116721 140944 170924 63997 497811 54349 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency 64524 24189 362706 29562 24362 83688 362383 24377 25741 292804 QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway 64803 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation 24842 24708 58919 60421 363333 310738 287647 29618 25317 29619 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway 24506 25398 25351 300992 50688 25559 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium 24600 25202 25523 60395 84494 66026 298496 66012 689123 282822 59320 497757 170848 29682 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway 29277 29296 286929 171522 24297 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway 24400 81666 24715 24180 24179 24310 ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway 170913 24565 83783 24644 29503 140668 24904 170924 140544 29504 362866 79127 298410 191575 89841 312382 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway 170913 29296 286929 171522 83511 25553 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) 114860 24645 289827 287835 83472 246232 298003 24385 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway 29277 293985 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway 286906 170913 287164 360734 498198 116598 24861 64367 680945 192235 117030 25617 24693 29527 140668 286929 303413 360243 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway 24216 24217 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency 24434 50555 292804 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis 297417 25721 117544 24379 29739 685245 25283 25458 81632 116686 497840 24399 290868 291133 24240 498486 29408 192268 295088 81670 297393 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification 290029 25139 29171 65054 114846 140925 24778 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) 29531 301544 288917 24616 24401 313047 29383 360719 24813 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation 24448 24400 81666 25262 24654 25023 81736 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism 500709 290651 499084 81677 83523 311355 116699 294292 316376 50560 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 266975 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling 498609 24185 24400 25262 81762 305509 24654 501099 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway 84489 79114 60351 170582 25114 25022 29500 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease 303565 498731 296973 24190 313843 25630 66020 171147 24333 316265 60416 292804 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell 25665 25398 25351 24952 689421 299940 300992 362242 50688 25559 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria 24189 24788 25659 291095 24192 24362 300089 307848 296571 300036 498731 310935 363145 24190 24638 300741 25741 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids 25413 288369 117035 83842 311849 305581 64460 84356 363516 25288 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin 24400 292661 24585 288057 293508 680149 81636 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation 113965 364975 25014 299201 140547 361272 298942 64554 29416 291640 291450 303272 296925 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 313121 309361 81649 311245 84351 287398 309295 116554 60350 680127 29260 301059 116667 361677 317468 363520 309165 364594 81736 310553 308267 25493 300447 289337 305353 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) 24598 64313 497840 24399 306574 680409 25611 81660 24264 25257 364064 29221 24401 25698 361612 59085 114027 289352 297969 29408 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway 286906 170913 287164 24565 360734 498198 396552 116598 24861 64367 680945 192235 117030 25617 113902 65036 286929 64550 498940 312382 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency 65152 362706 24190 501157 114508 64390 298655 83688 689374 362383 292804 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis 29142 287711 363069 85496 294088 METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway 24189 24362 83688 362383 292804 24377 64524 362706 290636 24645 298954 501157 25741 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency 25363 25757 25413 364975 25014 140547 24158 64304 170465 171155 170670 25287 25288 25618 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia 24962 287379 25044 306586 81660 298942 24792 245961 25257 303306 309312 293820 29253 29539 25134 304429 297113 114123 299857 266975 366959 58835 MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway 24715 24179 24310 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) 25117 25116 24298 192242 24294 307092 353498 29680 25146 360348 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine 307799 29431 310533 25522 309361 84351 81646 81771 24400 116554 116590 314436 293621 24516 116667 363855 24185 58960 293508 680149 81736 64639 114495 25493 295347 81647 689314 308106 309452 81745 114559 114486 25369 59326 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor 81666 25262 24680 24654 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria 29253 25375 24401 81683 56823 25699 308800 24267 290484 29383 360719 24311 65029 FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary 89833 24312 680308 300886 361472 303333 362657 315763 64300 25455 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism 25014 25244 296259 81632 29711 140547 301384 24624 298942 24158 29611 81708 85239 369018 314800 60581 293829 TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria 29470 29411 63864 170465 171155 170670 140547 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 294810 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency 24333 685529 361042 292804 24240 303565 498731 296973 24190 313843 171087 66020 171147 114508 81829 171053 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect 83688 362383 24377 64524 25741 50655 363061 25630 94173 24368 24644 298596 299201 157074 289950 289217 24333 25059 24399 361272 24651 24398 292804 298942 500983 79250 25027 24959 24479 81654 171087 170587 114096 29483 24551 114597 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis 29270 24312 29224 24192 29498 171128 29244 64192 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism 114860 24645 289827 287835 83472 246232 298003 24385 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) 25104 363061 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 361272 298942 79250 81654 171087 170587 114096 24551 114597 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine 300079 57809 64302 500547 29258 81770 81772 65136 64298 28298 29236 64205 499457 65043 117053 140661 292023 29257 499937 81776 689481 679852 311120 362631 29285 81764 122772 500019 691975 26962 25347 680585 680395 502741 81774 81773 297755 29284 83427 290641 81766 140654 83789 81767 81768 29287 29288 294282 360572 140662 291434 366030 122799 64307 94266 64306 287417 27139 293418 29282 64640 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway 170913 24565 680876 24842 84014 316231 140668 286929 114851 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway 24310 CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29412 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway 24715 24179 24310 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism 367747 65038 311647 171458 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia 24962 287379 25044 306586 81660 298942 24792 245961 25257 303306 309312 293820 29253 29539 25134 304429 297113 114123 299857 266975 366959 58835 LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis 25249 498332 299195 304542 29309 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease 24189 24362 24333 25059 292804 500983 25634 498731 24959 313843 171087 64201 362282 81829 171053 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB 24189 24362 24333 25059 292804 500983 25634 498731 24959 313843 171087 64201 362282 81829 171053 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease 289827 286954 83472 24434 497039 685076 362029 64035 25059 24385 292804 AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) 25104 363061 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 361272 298942 79250 81654 171087 170587 114096 24551 114597 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia 89833 29301 307212 24443 29253 29539 685999 25375 81676 291394 293871 89820 307492 299735 65029 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway 24627 498198 29296 286929 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) 29253 25375 24401 81683 56823 25699 308800 24267 290484 29383 360719 24311 65029 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids 24158 113965 117035 170465 171155 170670 140547 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism 83783 64473 81805 292915 294103 314694 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism 286906 287164 360734 116598 24861 64367 680945 192235 192242 117030 307092 25617 353498 25116 24950 117182 25147 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway 361523 29277 25375 29296 293985 24188 24424 286929 24299 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate 361596 54702 50655 308457 25104 363061 308913 170943 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 361272 298942 79250 24479 81654 171087 170587 114096 114597 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway 83785 54251 NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway 286906 25601 287164 360734 396552 116598 24861 64367 680945 192235 117030 25617 286954 396527 286989 83808 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency 65152 362706 24190 501157 114508 64390 298655 83688 689374 362383 292804 KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 286929 300992 50688 24297 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis 681361 29194 314553 310773 89841 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 313047 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis 303565 498731 296973 24190 313843 25630 66020 171147 24333 316265 60416 292804 LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism 65052 500709 306808 290651 363131 499084 114558 80849 81677 309855 64161 59319 316457 316376 287745 83523 171458 29390 307842 252899 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis 310848 301280 286963 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway 361523 63864 29277 396527 24299 24513 171155 171142 170670 25618 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 116483 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance 25552 25390 29639 116569 24211 25351 24212 24213 29132 25650 24214 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway 24715 24179 24310 METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway 25665 689421 299940 362242 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 29243 25048 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway 361523 29277 498198 396552 24188 316231 286929 171522 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway 432361 24680 59323 24329 29496 57027 29192 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway 140908 29271 29431 81822 25096 25193 363925 84014 65172 64185 58919 294568 25737 363875 288057 295378 83840 114851 293344 304813 116667 25267 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism 114027 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency 24189 25104 24362 24333 25059 294088 292804 29573 25634 500983 498731 24645 296973 24959 313843 171087 500965 64201 362282 25351 81829 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation 24250 24962 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis 24189 24644 24333 25059 24651 292804 25634 500983 65152 296973 24959 313843 25351 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) 314360 316033 353229 363494 499210 315222 361213 117185 360833 286896 83626 366697 65196 301543 303729 308589 301118 64369 300129 314438 50555 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 24434 50555 292804 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway 313121 309361 311245 84351 309295 24835 29260 301059 116667 306886 360640 25663 25625 156767 246756 84584 363520 24493 309165 83506 81736 25493 60341 50522 266610 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism 81822 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency 24250 689330 361286 24962 84350 680036 171347 287379 362657 81508 84596 290551 81640 LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) 25363 25757 25413 364975 25014 140547 24158 64304 170465 171155 170670 25287 25288 25618 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 171522 29571 619380 293985 29296 25398 286929 300992 50688 361523 171352 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway 25461 294141 24216 24217 24797 25320 25706 24260 25555 310218 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect 362383 24377 64524 25351 25741 292657 360975 50655 311254 25104 25630 94173 25179 24368 24644 362404 685778 298596 299201 289950 289217 24333 24399 298942 292804 500983 79250 25027 24959 24479 290636 24190 170587 171087 114096 24551 114597 CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism 25623 25059 292804 24645 289827 83472 24434 497039 685076 362029 64035 24385 288333 501907 497756 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL 84477 313845 83571 24888 287942 56718 24514 81504 54245 83840 64639 294790 500985 24918 314856 24577 24842 25513 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism 84575 315851 171400 83512 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency 81641 408206 362368 29739 64026 25283 24404 25458 116686 309465 116684 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease 314360 316033 353229 363494 499210 315222 361213 117185 360833 286896 83626 366697 65196 301543 303729 308589 301118 64369 300129 314438 50555 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism 29421 289219 25709 309070 304024 24451 291470 25374 314323 361338 24434 309391 116599 501907 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism 24950 117182 192242 25322 25355 25147 292915 501907 266685 25146 24800 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism 689330 291450 29443 171347 81508 81522 290551 BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency 288240 116719 306262 FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway 24715 24179 24310 ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 499374 362631 81764 81765 296644 25347 680395 293638 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL 84477 313845 83571 24888 287942 56718 24514 81504 54245 83840 64639 294790 500985 24918 314856 24577 24842 25513 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency 24792 25104 171087 301254 81670 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway 24329 FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway 170913 301005 58978 396552 498198 293985 362329 113902 286929 286989 498940 312382 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism 498198 24188 286929 24299 266686 246298 114106 690953 170635 84497 313689 64047 361523 286906 116676 287164 252931 360734 171352 314264 116598 363471 24861 299511 64367 362757 680945 89826 192235 679520 117030 154985 25617 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 171522 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency 29253 25375 24401 81683 56823 25699 308800 24267 290484 29383 360719 24311 65029 CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway 361523 170913 29277 498198 29296 286929 64803 24297 84024 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis 266807 292279 24826 114613 54314 66021 85431 79129 79107 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation 24788 25659 24192 24362 307848 296571 300036 310935 498731 24190 24638 302915 300741 306164 25741 316003 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine 307799 29316 29431 310533 25522 309361 84351 81646 81771 24400 116554 116590 314436 293621 24516 116667 363855 24185 58960 293508 680149 81736 64639 114495 25493 295347 81647 689314 308106 309452 81745 114559 114486 81636 59326 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome 24189 24644 24333 25059 24651 292804 25634 500983 65152 296973 24959 313843 25351 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell 24797 25398 25351 300992 50688 25559 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling 60445 24185 24855 24954 116636 117045 298947 497932 56718 50719 83840 24506 25467 29376 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency 29270 24312 29224 24192 29498 171128 29244 64192 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency 79238 25014 690163 117099 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) 25055 192242 307092 252898 309527 25541 25429 301517 81924 25428 79244 25284 29725 79111 362782 246211 301264 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling 29560 361612 24494 293615 29260 287362 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC 24189 24362 24333 25059 292804 500983 25634 498731 24959 313843 171087 64201 362282 81829 171053 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway 396552 498198 286929 286989 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency 25104 24192 685778 25014 289950 24651 311569 298942 24439 294320 307858 81654 29539 500965 299203 362282 60581 170570 24551 24552 680021 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway 24400 81666 24715 24180 24179 24310 TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway 24310 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 29335 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin 24400 81646 24668 25324 293508 680149 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism 286906 287164 360734 498198 116598 24861 64367 680945 192235 117030 25617 24296 24267 25322 25355 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) 25363 25757 25413 364975 25014 140547 24158 64304 170465 171155 170670 25287 25288 25618 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway 24329 NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway 25262 24680 305509 81649 25636 24654 171492 81504 116554 29716 116590 114493 24239 24703 314436 293621 24516 300992 116667 50688 363855 63836 170851 25194 81668 25096 81662 81686 313845 25400 116700 81707 303200 25447 25329 83805 24329 79255 25023 24330 25433 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway 29261 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism 65052 500709 306808 64473 290651 363131 499084 114558 24655 80849 295230 81677 116482 59319 83523 171458 29390 307842 252899 171088 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) 25363 25757 25413 364975 25014 140547 24158 64304 170465 171155 170670 25287 25288 25618 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 313121 309361 81649 311245 84351 287398 309295 25747 54287 116554 60350 680127 29260 314322 314436 301059 24516 116667 303200 361677 317468 363520 309165 364594 81736 310553 114495 308267 25493 300447 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis 29653 303698 60666 114101 366196 306582 29390 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway 24680 363875 287398 313050 81504 81511 315609 85385 301348 116554 25738 24703 314322 314436 293621 24516 25513 116667 25150 170851 313845 25156 298947 24674 309165 25023 81736 50689 25493 246781 29434 50522 361400 300678 305897 25300 311658 24675 171378 25710 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway 117544 497811 362329 54349 363875 65194 691960 690050 25368 24465 116721 140944 170924 63997 295088 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway 24239 300992 50688 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway 29597 50646 24680 25738 25023 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type 24250 689330 361286 24962 84350 680036 171347 287379 362657 81508 84596 290551 81640 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) 65156 83585 362720 24240 299976 499956 29261 311422 295620 313560 362638 314004 26956 315219 246272 65135 81656 290741 116593 58964 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway 29539 25262 497811 29495 24680 24409 24408 24674 24598 293508 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect 83688 362383 24377 50655 363061 25104 25630 24368 24644 362404 295356 685778 298596 299201 290685 157074 289950 289217 24333 24399 361272 24398 60416 292804 298942 500983 24959 290636 24479 81654 170587 171087 114096 24551 114597 299052 24778 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia 25586 54349 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency 297417 25721 117544 24379 29739 685245 25283 25458 81632 116686 497840 24399 290868 291133 24240 498486 29408 192268 295088 81670 297393 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome 65052 363131 114558 24654 366508 50557 85238 116723 309855 64161 24329 59319 192260 316457 361632 24337 54259 25513 307842 116699 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency 25117 25116 24298 192242 24294 307092 353498 29680 25146 360348 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway 25590 25390 65180 29639 25601 24316 498198 29686 24211 24473 29412 25121 24212 171522 29571 29277 619380 29296 25398 286929 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome 25117 25116 24298 192242 24294 307092 353498 29680 25146 360348 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic 287478 293638 192172 24401 500965 29739 24962 25283 81718 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) 170698 60351 338443 29500 170924 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids 25413 29539 117035 311849 305581 64460 114209 84356 363516 25288 85255 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 304917 29243 25048 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 24189 24362 24333 25059 292804 500983 25634 498731 24959 313843 171087 64201 362282 81829 171053 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome 25634 24390 83782 289827 298003 246272 298410 24528 24778 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway 29261 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway 25590 25390 65180 29639 25601 24316 29686 24211 24473 29412 25121 24212 29571 619380 25398 300992 50688 24409 24408 24213 24898 29132 83511 24664 25650 25553 24214 54239 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB 24333 685529 361042 292804 24240 303565 498731 296973 24190 313843 171087 66020 171147 114508 81829 171053 GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway 361523 286906 287164 360734 396552 116598 24861 64367 680945 192235 117030 25617 29277 293985 286929 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 25104 24192 685778 25014 289950 24651 311569 298942 24439 294320 307858 81654 29539 500965 299203 362282 60581 170570 24551 24552 680021 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 63864 79238 24450 25014 54349 25244 690163 24513 81632 361884 29711 29592 140547 361215 301384 63938 24624 294972 298942 24158 29611 81708 29539 64304 170465 25618 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism 314360 316033 353229 363494 499210 315222 361213 117185 360833 286896 83626 366697 65196 301543 303729 308589 301118 64369 300129 314438 50555 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) 25117 25116 24298 192242 24294 307092 353498 29680 25146 360348 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency 24962 287379 25044 306586 81660 298942 24792 245961 25257 303306 309312 293820 29253 29539 25134 304429 297113 114123 299857 266975 366959 58835 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency 24962 287379 25044 306586 81660 298942 24792 245961 25257 303306 309312 293820 29253 29539 25134 304429 297113 114123 299857 266975 366959 58835 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis 24189 25634 500983 65152 498731 24959 313843 24333 25059 24651 292804 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production 282839 24400 293508 680149 24664 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 24434 50555 292804 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway 361523 29277 25375 498198 293985 24188 286929 24299 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway 24216 24217 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway 29495 24680 24409 24408 24674 24598 293508 50663 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway 25242 25690 299331 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway 170851 24680 24514 81504 25023 85385 50689 24918 116554 25313 25738 116549 314322 24703 314436 59323 293621 501099 24516 25125 116667 363855 25676 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling 24185 24400 81762 691774 305509 501099 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation 24189 24788 25659 291095 24192 24362 300089 307848 296571 300036 498731 310935 363145 24190 24638 300741 25741 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease 24434 50555 292804 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease 24189 25634 500983 65152 498731 24959 313843 24333 25059 24651 292804 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) 24598 64313 497840 24399 306574 680409 25611 81660 24264 25257 364064 29221 24401 25698 361612 59085 114027 289352 297969 29408 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis 25055 192242 307092 252898 309527 25541 25429 301517 81924 25428 79244 25284 29725 79111 362782 246211 301264 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency 81641 408206 362368 29739 64026 25283 24404 25458 116686 309465 116684 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway 29296 286929 171522 24297 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway 171352 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation 65152 498731 24191 24190 114508 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 307492 317646 25538 29304 81775 124323 296709 362041 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency 24189 24362 83688 362383 292804 24377 64524 362706 290636 24645 298954 501157 25741 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway 171522 83511 25553 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway 84551 79430 25390 54302 29639 25672 29509 25550 24211 113918 29503 24768 24212 83509 307811 50567 691209 50719 25122 25065 54300 24767 116726 29484 24213 29132 25650 170573 24214 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin 24400 25477 116700 81646 24668 25329 293508 680149 81636 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation 25552 25390 29639 116569 24211 25351 24212 24213 29132 25650 24214 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency 24189 25104 24362 24333 25059 294088 292804 29573 25634 500983 498731 24645 296973 24959 313843 171087 500965 64201 362282 25351 81829 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism 29653 60666 25375 406165 24192 24539 24538 246115 25062 64369 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation 500983 498731 25630 60416 292804 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway 64524 24189 362706 29562 24362 83688 362383 24377 25741 292804 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency 25623 25059 292804 24645 289827 83472 24434 497039 685076 362029 64035 24385 288333 501907 497756 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis 29653 60666 406165 313977 84497 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency 24250 24962 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway 24216 24217 VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway 24400 81666 24715 24180 24179 24310 CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia 81708 29539 24379 81632 65135 29473 81656 307212 116593 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 289827 286954 83472 24434 497039 685076 362029 64035 25059 24385 292804 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation 171385 685750 299201 361272 298942 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 499374 362631 81764 81765 314442 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism 500709 306808 290651 499084 80849 81677 316376 83523 171458 311355 116699 294292 50560 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway 81716 29251 24946 309004 302470 29393 24366 24367 25692 85253 361969 260320 289055 304929 25584 60327 306761 290757 304917 29243 25048 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II 113965 364975 25014 299201 140547 361272 298942 64554 29416 291640 291450 303272 296925 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action 24448 24400 81666 25262 24654 25023 81736 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria 25014 25244 296259 81632 29711 140547 301384 24624 298942 24158 29611 81708 85239 369018 314800 60581 293829 AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency 24950 117182 192242 25322 25355 25147 292915 501907 266685 25146 24800 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC 24333 685529 361042 292804 24240 303565 498731 296973 24190 313843 171087 66020 171147 114508 81829 171053 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule 79430 25390 24216 29639 24217 24211 25386 24212 65133 54300 24715 29715 116469 24213 29132 25650 24214 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria 25721 29221 25698 59085 497840 24399 192268 306574 81670 25611 305540 292657 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway 24310 PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway 81645 25390 29639 29693 114862 24211 25636 29713 24212 84020 29717 25470 59266 25472 25559 83535 25665 500450 50599 116649 619380 24925 29712 24239 29715 689421 65195 59324 25471 300992 50688 25252 117018 25560 171138 24213 299940 29132 362242 25650 24214 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells 24680 25155 499356 363875 24835 313050 25047 81504 81511 116553 116630 54259 116554 116590 25738 24605 24703 287287 293621 25316 81515 25513 24525 363855 25150 170851 24185 58960 84477 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation 309361 24680 24654 24600 84351 81646 309295 24693 81736 50689 116590 689314 408199 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway 574523 361523 83783 498198 396552 24890 84493 25256 286929 171522 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 24627 361274 117544 25028 81643 292072 362329 303179 117533 289276 25202 297998 314312 83585 297389 362720 365320 287420 290029 613267 116484 66012 497811 298954 315150 311422 24165 24465 63885 140946 309532 295088 81636 288259 58964 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway 25309 25591 362456 64044 25402 50669 315530 78963 24516 299012 25166 58918 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria 65152 498731 24191 24190 114508 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria 81641 408206 362368 29739 64026 25283 24404 25458 116686 309465 116684 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway 293985 25086 290623 362676 310848 24404 500801 114097 25527 65030 50549 361523 65210 299732 287454 286904 171516 59103 25526 25290 287425 24886 81639 266604 24693 29527 29224 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine 300079 57809 64302 500547 29258 81770 81772 501206 65136 690468 64298 28298 29236 680700 64205 499457 306511 65043 117053 140661 291556 499374 362631 81764 81765 296644 25347 680395 81774 81773 684988 297755 65139 29284 83427 290641 81766 140654 290825 83789 81767 81768 29287 29288 294282 64156 500817 360572 140662 291434 245981 367324 366030 122799 64307 94266 64306 287417 27139 293418 50718 29282 64640 367874 64638 25348 29426 29752 317646 25538 29304 81775 124323 296709 362041 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome 303565 498731 296973 24190 313843 25630 66020 171147 24333 316265 60416 292804 INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine 25461 24400 81646 24668 293508 680149 81636 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis 81782 140910 25055 114100 310645 309262 291211 308100 81681 81726 25675 83791 89784 29580 25427 29540 117278 29230 298298 293688 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling 24185 24400 25262 305509 24654 66025 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate 50655 25104 363061 94173 25179 24368 362404 298596 685778 299201 157074 289950 289217 361272 298942 79250 24479 81654 171087 170587 114096 114597 192268 361596 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) Irinotecan pathway%WikiPathways_20260211%WP124%Rattus norvegicus Irinotecan pathway 24565 312382 25303 171118 100125372 113902 29225 65036 Glucuronidation%WikiPathways_20260211%WP1276%Rattus norvegicus Glucuronidation 289827 679990 289632 25058 83472 24645 286954 289533 83808 286954 305264 63867 286989 Non homologous end joining%WikiPathways_20260211%WP1277%Rattus norvegicus Non homologous end joining 360748 25019 309995 64012 EBV LMP1 signaling%WikiPathways_20260211%WP1278%Rattus norvegicus EBV LMP1 signaling 309452 116554 309165 286908 246756 24481 84351 311245 309361 313121 81736 81780 360640 309361 116590 Estrogen signaling%WikiPathways_20260211%WP1279%Rattus norvegicus Estrogen signaling 84577 50658 308415 307485 310784 363067 116590 266713 58919 81673 292778 84578 291703 24890 170915 84351 498109 289561 25636 361365 682902 171150 24516 497672 24185 303918 373541 294236 361580 24400 306516 83805 293621 81674 288588 313845 114486 170851 81649 81736 314436 314612 297893 288533 117526 54244 171104 314322 83503 81504 170922 294693 294018 680149 117017 84580 288651 363633 84389 309361 Transcriptional activation by Nfe2l2 in response to phytochemicals%WikiPathways_20260211%WP1280%Rattus norvegicus Transcriptional activation by Nfe2l2 in response to phytochemicals 24680 116554 288480 24253 83619 24451 54267 313633 24314 29739 Hypothetical network for drug addiction%WikiPathways_20260211%WP1281%Rattus norvegicus Hypothetical network for drug addiction 25050 294504 24411 305509 25432 50592 307861 362317 24412 29241 29340 24418 24414 29437 50689 116590 306255 24410 24316 29627 170851 24409 24245 24408 25636 Methylation%WikiPathways_20260211%WP1282%Rattus norvegicus Methylation 25331 171347 24661 81676 368066 24267 Oxidative phosphorylation%WikiPathways_20260211%WP1283%Rattus norvegicus Oxidative phosphorylation 114630 681024 362588 29754 361385 362344 312258 26197 679739 689938 64539 293991 296658 293453 25488 297990 316632 362440 192241 171375 293130 26197 26204 499529 26200 681418 102553861 171528 171290 100361261 295923 26202 26199 291660 289218 293652 294964 140608 26193 94271 690441 26203 65262 293655 26201 26194 EPO receptor signaling%WikiPathways_20260211%WP1284%Rattus norvegicus EPO receptor signaling 24514 83805 298947 81504 24335 85385 116551 50689 170851 58960 24185 116590 252971 25126 24918 25125 24699 116680 24703 313845 29376 25676 Metapathway biotransformation%WikiPathways_20260211%WP1286%Rattus norvegicus Metapathway biotransformation 362035 171445 498489 116631 116632 116631 116632 310848 246248 295430 316325 290623 246767 363618 299566 500801 690050 293779 81676 29725 84493 295934 25279 84468 64305 362782 499689 29326 120093683 500892 24192 293451 100359484 25426 114846 308445 360268 24298 26760 308190 24902 24912 114700 312495 499422 78959 25256 362228 368066 81869 311257 314694 291770 498166 25428 681913 54246 294449 297029 499302 292155 81924 24296 116686 58953 364476 24294 64352 289533 29633 307092 310855 500257 25429 140568 25315 303669 83783 288108 361631 303218 292915 25458 65030 307859 24423 58981 246245 29738 361718 246247 154985 25086 691394 500359 684979 25146 307838 171341 286954 296972 64570 24426 24267 289197 192242 25427 304322 Amino acid conjugation of benzoic acid%WikiPathways_20260211%WP1287%Rattus norvegicus Amino acid conjugation of benzoic acid 293779 311569 Wnt signaling pathway and pluripotency%WikiPathways_20260211%WP1288%Rattus norvegicus Wnt signaling pathway and pluripotency 364754 24205 29382 303251 84353 303181 24516 84006 25619 116466 54244 24672 24673 363595 24680 161452 499593 25272 64512 500047 114487 303586 64566 117281 312451 25682 85420 311881 497961 303330 295341 25023 316526 83721 83572 140584 24842 58919 24882 60660 50658 294562 114850 81717 25522 312781 64558 303811 25445 29134 266608 117273 364952 308068 79257 414065 84027 84426 117104 117256 266715 311163 313121 140584 29340 363122 25406 282582 170538 362102 293649 64033 Type II interferon signaling IFNG %WikiPathways_20260211%WP1289%Rattus norvegicus Type II interferon signaling IFNG 25712 116465 360697 84598 24514 89829 252971 25622 305896 170538 24714 291100 366126 24481 24599 304266 295277 364723 24967 24811 192281 245920 85483 66021 24494 294091 54287 24508 246759 298693 292060 290749 Apoptosis%WikiPathways_20260211%WP1290%Rattus norvegicus Apoptosis 492821 58918 116502 24508 81736 246097 100360940 24185 64639 25493 306886 290749 81525 25008 364081 25402 50669 25625 25718 309165 309361 24887 156767 64625 500592 25272 687813 84351 296953 114214 292892 64314 362675 64026 24483 309295 311786 60434 25513 246756 64041 364420 24516 140923 84359 293624 291100 24842 287398 63879 25385 294071 266610 64547 116667 246334 Phase I biotransformations non P450%WikiPathways_20260211%WP1291%Rattus norvegicus Phase I biotransformations non P450 307660 290401 25055 312086 685645 296851 679817 84024 One carbon metabolism%WikiPathways_20260211%WP1292%Rattus norvegicus One carbon metabolism 25331 81508 24312 680308 361472 85309 81522 362657 89833 444985 312192 64392 290947 287379 288259 444984 29443 64365 Selenium metabolism selenoproteins%WikiPathways_20260211%WP1293%Rattus norvegicus Selenium metabolism selenoproteins 498398 81736 297437 103689947 140927 362624 362713 65241 83619 113922 29326 685059 24516 292759 308993 286900 365802 29475 29360 309165 25545 290549 50551 314322 25430 64317 25620 259233 291314 266975 500255 499113 315216 64640 100362027 367846 65162 24360 Nod like receptor NLR signaling pathway%WikiPathways_20260211%WP1294%Rattus norvegicus Nod like receptor NLR signaling pathway 309361 309295 309165 116554 313633 313121 84351 171369 Mismatch repair%WikiPathways_20260211%WP1295%Rattus norvegicus Mismatch repair 81513 59294 81709 89809 100360342 25737 287524 Homologous recombination%WikiPathways_20260211%WP1296%Rattus norvegicus Homologous recombination 293144 499870 360254 287524 85482 297561 361698 313063 102550523 59294 287524 289758 64012 Retinol metabolism%WikiPathways_20260211%WP1297%Rattus norvegicus Retinol metabolism 114106 362662 24188 24705 155192 314264 313689 312495 432367 266603 114628 24539 25086 89826 25073 292915 64047 361801 353252 246298 25271 100145871 29646 83783 154985 29184 499985 24172 83574 29563 293049 25703 24706 ErbB signaling pathway%WikiPathways_20260211%WP1299%Rattus norvegicus ErbB signaling pathway 314612 84027 690919 497931 29414 25738 64022 116554 112400 24329 24337 64639 29183 361388 314436 24827 313845 83805 81504 498596 59325 24918 114851 170851 24516 25433 25313 116636 54245 24680 83840 83571 25400 56718 293621 292699 292756 363855 116590 25614 311860 432361 Aflatoxin B1 metabolism%WikiPathways_20260211%WP1300%Rattus norvegicus Aflatoxin B1 metabolism 171445 26760 499422 24423 25315 Mitochondrial gene expression%WikiPathways_20260211%WP1301%Rattus norvegicus Mitochondrial gene expression 25521 83474 308140 289307 294007 85261 363735 299604 293701 312195 295263 83516 291567 679712 25050 24674 Estrogen metabolism%WikiPathways_20260211%WP1302%Rattus norvegicus Estrogen metabolism 24267 360268 83783 310326 24314 24296 24423 25426 Polyol pathway%WikiPathways_20260211%WP1303%Rattus norvegicus Polyol pathway 25659 24190 24192 24788 Toll like receptor signaling pathway%WikiPathways_20260211%WP1309%Rattus norvegicus Toll like receptor signaling pathway 448830 81736 25408 24516 305354 289337 25513 81736 81649 311245 25233 81780 361677 64546 298947 305353 25272 497931 309361 29414 308267 25493 84405 311245 24835 171369 24481 25353 25542 310553 245920 29260 317468 298205 363984 293624 287398 24494 684440 313121 114495 364867 292892 309361 24498 56822 50689 366508 29513 60350 24481 288264 116554 306886 29469 296953 116590 170851 266610 311245 690894 60664 116596 363875 310553 29741 363855 246759 364594 24185 303200 309165 116637 309295 309452 84351 314322 170911 305236 50658 Peptide GPCRs%WikiPathways_20260211%WP131%Rattus norvegicus Peptide GPCRs 24180 289615 24182 25245 81509 25264 24938 260319 60463 117027 117029 308163 287673 363682 100124593 60628 25449 25477 25360 50577 29234 29235 24326 50672 24889 25706 292409 690158 292413 84007 54258 29310 25635 25726 29358 66024 25340 366274 64636 24613 29335 25601 29256 81668 84022 24807 25007 24808 282829 25033 54305 171044 25555 25354 100909648 29462 25342 282839 29471 Selenium micronutrient network %WikiPathways_20260211%WP1310%Rattus norvegicus Selenium micronutrient network 292301 24404 25526 25290 26195 116686 64533 25527 24786 24886 362657 59113 83512 29360 259233 290549 497811 81522 84575 26198 24248 64317 Folic acid network%WikiPathways_20260211%WP1311%Rattus norvegicus Folic acid network 292301 25527 259233 24786 83512 24250 50551 24248 362657 59113 25526 290549 25545 64317 81522 25290 26195 685059 116686 497811 64533 24404 26198 S1P receptor signal transduction%WikiPathways_20260211%WP1312%Rattus norvegicus S1P receptor signal transduction 170897 308589 84431 83537 29733 306792 24654 85240 29322 50689 116590 54268 60352 25686 25643 24185 25233 29414 289021 Fatty acid omega oxidation%WikiPathways_20260211%WP133%Rattus norvegicus Fatty acid omega oxidation 25086 266682 310903 24172 24172 24306 100145871 29646 24188 171178 304500 29539 24296 IL 6 signaling pathway%WikiPathways_20260211%WP135%Rattus norvegicus IL 6 signaling pathway 299147 313121 497961 303330 25125 299331 367901 54244 24471 117281 25402 81736 361388 25126 64639 24253 84482 170538 293621 116671 25614 24499 84492 313929 114495 65038 140908 29477 29517 24673 24498 81504 170915 25622 170851 361597 84027 363122 50689 116590 24185 302415 83840 24337 84598 25513 81649 24703 691318 25734 24672 24514 117269 682033 84477 362102 79113 308106 294515 58918 309179 312754 117256 171369 297893 313845 502531 25205 24918 24516 140926 24817 25150 25738 363875 362110 367786 89829 85385 81515 360820 29741 58960 116554 287398 117104 50646 314322 24708 60660 116636 289014 117045 Nuclear receptors in lipid metabolism and toxicity%WikiPathways_20260211%WP139%Rattus norvegicus Nuclear receptors in lipid metabolism and toxicity 313210 25747 25303 25664 84385 83569 24705 81924 114628 85264 29277 154985 65035 24873 140668 361523 25428 24706 114700 24307 24891 25279 58852 170913 25086 84356 25682 25270 170913 Myometrial relaxation and contraction pathways%WikiPathways_20260211%WP140%Rattus norvegicus Myometrial relaxation and contraction pathways 685451 25522 64532 114207 25391 24679 24681 81636 29340 59077 60449 114117 24678 314322 59075 25342 117558 114120 84583 80850 54295 24516 64508 58979 293508 406169 29307 24241 305509 25388 24598 308118 81749 689560 289076 56011 24498 59076 114205 399684 295144 25576 171140 54296 688228 54289 25023 116744 56820 24246 85420 24600 25687 114846 81648 24680 81667 25342 360622 54290 81821 54294 29693 362477 81666 29753 25504 25725 29481 84420 282840 29337 24494 108352647 25026 360857 25679 85421 287876 100361457 245986 363866 294962 25521 59293 81822 289596 364738 170538 363735 25656 25262 24245 58959 25616 24627 304063 25389 54223 29480 114705 29715 64055 25387 24392 56010 25685 266709 24626 680149 114906 25577 298400 29275 24484 25738 366960 81647 302950 29437 24400 363925 54293 29322 25400 81736 497757 Statin pathway%WikiPathways_20260211%WP145%Rattus norvegicus Statin pathway 24530 25728 24539 25292 25073 310900 25675 296371 313210 25428 81782 Nucleotide metabolism%WikiPathways_20260211%WP146%Rattus norvegicus Nucleotide metabolism 24689 59294 362329 302642 83782 680308 29240 24465 85472 24312 84596 289276 Kit receptor signaling pathway%WikiPathways_20260211%WP147%Rattus norvegicus Kit receptor signaling pathway 84427 25513 29741 85385 171081 81504 307200 305828 500616 54241 54245 83805 114633 24514 363616 116680 305269 24680 25738 24918 25126 298947 114203 498416 24185 84492 81515 312477 116689 25622 81771 25094 116590 311860 79113 25734 25676 361597 287942 252971 296603 60450 64639 313845 170915 25150 25023 293621 24703 305539 296072 84357 171136 364420 367901 64030 170851 25125 29365 Interactions between CFTR and other ion channels%WikiPathways_20260211%WP1485%Rattus norvegicus Interactions between CFTR and other ion channels 24255 24767 59114 24768 Intracellular trafficking of CFTR%WikiPathways_20260211%WP1486%Rattus norvegicus Intracellular trafficking of CFTR 24255 54319 59114 29448 362650 81830 24255 59114 362650 81830 TNF alpha and mucus production in lung epythelium%WikiPathways_20260211%WP1487%Rattus norvegicus TNF alpha and mucus production in lung epythelium 362491 116590 170851 24827 81736 309165 117269 25625 24835 85385 246756 309361 24329 311786 84351 24703 81736 313845 24572 25493 29260 309295 81504 24498 CFTR activity in the plasma membrane%WikiPathways_20260211%WP1488%Rattus norvegicus CFTR activity in the plasma membrane 25636 497197 85240 24654 24681 24255 65144 29322 78975 64630 83427 24672 54319 116501 65144 59114 Translation factors%WikiPathways_20260211%WP149%Rattus norvegicus Translation factors 27137 307503 116636 171145 501582 287703 365684 317163 287436 288516 298573 303300 296302 288599 299027 117019 361845 305506 54287 64514 287986 308306 24799 170848 293725 691947 25435 84005 303831 117045 300035 300033 292148 192234 29702 287444 293427 302697 Adipogenesis%WikiPathways_20260211%WP155%Rattus norvegicus Adipogenesis 24482 25527 25682 289311 24391 25585 24918 25126 114587 24413 60584 24253 154985 312495 25271 24705 58852 24539 78968 246097 680111 85471 25159 25664 309957 498607 499497 81518 24152 24835 81683 59086 24617 25139 246074 85489 25608 246250 54249 246299 24708 81758 246253 298199 24179 114851 399489 311562 117062 25629 24498 25112 299626 25695 83470 29373 25667 25296 308690 84482 84410 171356 83516 313929 83724 25747 25125 252971 89829 313173 81680 25205 282635 289747 24860 282582 83721 24817 83574 295691 24506 297508 306759 246273 54254 81808 304157 24684 362972 362160 29560 58954 89803 54299 360801 85497 114090 116543 29452 25690 294362 295062 79216 361722 60374 311821 313564 313977 25330 362282 361042 29376 362261 Glycogen metabolism%WikiPathways_20260211%WP160%Rattus norvegicus Glycogen metabolism 24701 24673 361377 25623 309179 140671 64561 117256 25739 289827 690987 50686 363122 81675 117281 24244 24672 60660 362029 312754 50663 678739 117104 84027 29353 288333 24645 362102 Small ligand GPCRs%WikiPathways_20260211%WP161%Rattus norvegicus Small ligand GPCRs 114211 57302 25637 81752 84023 306792 29733 25248 58949 116744 292661 498475 24929 25652 Oxidative stress response%WikiPathways_20260211%WP173%Rattus norvegicus Oxidative stress response 171341 24787 81736 81524 25272 24451 81649 79129 50551 314322 24248 24296 24517 29487 25352 497811 64317 116686 79462 24314 24786 Focal adhesion%WikiPathways_20260211%WP188%Rattus norvegicus Focal adhesion 29220 25567 29169 116669 117036 25313 360457 24446 24482 25266 94203 294754 25021 24511 309684 311061 295347 171337 85385 114858 114636 25404 29161 25150 81504 83805 170922 363425 81634 29195 290905 85490 29393 84352 24477 192362 24718 25353 364403 24329 24337 79113 54251 25734 25718 24553 25267 24629 296472 305311 170908 303882 114509 114495 60352 116590 58960 303200 170851 25614 299012 360820 29153 81745 24185 25233 81762 25537 314641 117558 81822 287876 100361457 84027 25513 29741 50557 363875 366957 29431 29433 29432 79429 89811 114111 25414 54245 63881 64465 64639 50658 24516 58919 64033 25654 294279 306628 361821 25304 309368 307582 309816 140433 298941 305078 445442 292406 681309 116640 363458 304913 311862 24628 25589 366275 500340 303247 362800 257645 29302 83577 296456 308995 64350 499271 364786 685004 310683 315744 685269 114517 311144 360606 685269 313494 170911 366508 298947 497931 116554 307483 313845 81649 293621 305679 361517 309081 24703 114486 114486 29360 54268 314436 29414 116670 288057 292756 296078 311450 Glucocorticoid effect on target gene expression%WikiPathways_20260211%WP1963%Rattus norvegicus Glucocorticoid effect on target gene expression 260321 500598 26198 24653 24413 266759 361568 81736 25493 25380 83514 81736 VEGFR 3 signaling%WikiPathways_20260211%WP1964%Rattus norvegicus VEGFR 3 signaling 58918 50689 25738 24185 116590 114110 85385 308451 298947 114111 360457 81504 64639 24600 VEGF receptor signal transduction%WikiPathways_20260211%WP1965%Rattus norvegicus VEGF receptor signal transduction 60664 24680 81504 25738 310688 24185 114111 89811 85385 24703 360820 83805 289014 246146 85385 84006 116590 116590 64639 58918 24600 363875 94203 Genetic alterations of lung cancer%WikiPathways_20260211%WP1968%Rattus norvegicus Genetic alterations of lung cancer 170911 24337 24329 116590 170851 24703 305302 24185 311807 59086 50554 29357 81809 58919 24708 399489 311562 25312 314856 54244 24842 25729 114851 366508 Serotonin and anxiety%WikiPathways_20260211%WP2132%Rattus norvegicus Serotonin and anxiety 29412 24412 29595 54323 116647 364206 24674 24473 25187 25023 314322 81648 Brain derived neurotrophic factor%WikiPathways_20260211%WP2148%Rattus norvegicus Brain derived neurotrophic factor 24225 24225 25054 25692 24617 116590 24596 85253 170851 24703 24225 Nuclear receptors%WikiPathways_20260211%WP217%Rattus norvegicus Nuclear receptors 361801 293701 24706 24413 60349 50659 54278 684085 113984 24873 83826 24831 259241 81812 368158 83574 25682 81808 25664 362550 25271 25149 58851 58852 24705 24890 84385 245980 25747 25735 299210 65035 Osteoblast signaling%WikiPathways_20260211%WP227%Rattus norvegicus Osteoblast signaling 24694 117516 25295 25267 170583 29393 25548 25295 24629 Nuclear factor erythroid derived 2 like 2 signaling pathway%WikiPathways_20260211%WP2376%Rattus norvegicus Nuclear factor erythroid derived 2 like 2 signaling pathway 83472 24681 287876 100361457 114851 24189 289990 305540 299602 84027 29437 116484 64188 295037 81822 313121 24605 24786 57298 310392 25522 25581 29741 499688 24424 295362 116686 304127 29739 25073 50689 24787 116554 114846 363855 25513 289021 681050 497932 361632 114495 497672 29677 25256 24778 25023 83619 65052 50658 81827 24680 29292 25319 114509 113894 289197 29702 499689 171341 25352 309465 85420 287642 246760 170851 84006 170915 83688 84509 24534 361568 117254 192255 64352 116590 85430 79130 116720 25375 24516 497931 313834 25260 293621 54244 24451 64191 291084 170538 81649 140668 170924 116643 24423 365355 170911 171445 117262 24842 26760 24565 116667 296972 29224 102556347 24377 29340 85252 29275 25365 295549 24426 25458 291796 25150 366508 289623 60664 297029 78959 24314 29487 25315 24703 81633 25445 Spinal cord injury%WikiPathways_20260211%WP2433%Rattus norvegicus Spinal cord injury 24596 287437 498666 25613 29190 289392 29364 79426 116591 257651 25167 24494 24599 287287 29619 24598 116562 24498 29260 314322 59086 24330 25712 24547 83765 362119 81503 25293 29221 316539 245920 25405 81687 58982 65047 360272 83467 114523 308739 25663 24493 114105 24770 360426 29354 29692 25380 25651 308565 24387 24807 116651 24708 24680 399489 311562 116590 58919 25112 50689 25402 24842 314694 114122 290905 64133 58968 25393 140586 24408 81818 24674 29423 25639 29409 295342 25537 450224 113912 65146 85431 100314002 54237 25453 361324 24392 24225 Sulindac metabolic pathway%WikiPathways_20260211%WP2541%Rattus norvegicus Sulindac metabolic pathway 24296 361286 29447 Relationship between glutathione and NADPH%WikiPathways_20260211%WP2562%Rattus norvegicus Relationship between glutathione and NADPH 29739 24377 292804 25290 246097 50555 192227 289827 289632 310378 114214 29292 501157 116554 24887 114851 24651 25402 498881 24383 303448 100360180 117548 83472 288562 116686 81641 291984 25319 24426 24333 24189 362383 290636 114097 24842 24644 24314 64678 24959 24645 83688 24565 24385 64524 25458 116484 25741 84359 365057 296654 Tryptophan metabolism%WikiPathways_20260211%WP270%Rattus norvegicus Tryptophan metabolism 66029 65210 313375 246281 60421 25120 314856 24311 63864 140547 364975 360975 171385 56823 116682 64206 24848 314442 24248 29416 298298 65183 25429 688283 65029 368066 24296 24894 24895 25053 25086 25426 685222 54246 56266 113965 24188 304500 29539 64040 361585 Monoamine GPCRs%WikiPathways_20260211%WP276%Rattus norvegicus Monoamine GPCRs 24448 24175 25324 29238 25461 24260 29412 25195 79247 25432 25645 24173 81645 64354 25323 25229 65032 25111 53949 25083 29595 60448 24316 25689 24925 24174 25187 24473 29413 Matrix metalloproteinases%WikiPathways_20260211%WP278%Rattus norvegicus Matrix metalloproteinases 94339 81686 25481 291848 81687 303384 29543 498028 288626 25246 65205 366964 81707 293573 25358 83513 24835 680130 mir219 in oligodendrocyte differentiation and myelination%WikiPathways_20260211%WP2811%Rattus norvegicus mir219 in oligodendrocyte differentiation and myelination 361895 313554 25267 29458 64619 293165 79225 Pentose phosphate pathway%WikiPathways_20260211%WP282%Rattus norvegicus Pentose phosphate pathway 24377 290636 501157 83688 362383 64524 100360180 117548 p38 Mapk signaling pathway%WikiPathways_20260211%WP294%Rattus norvegicus p38 Mapk signaling pathway 289014 81504 311786 498183 24471 85385 114495 500690 363875 29591 81518 81647 365057 500526 313121 306886 314384 81649 314436 60661 293621 64465 24653 287398 81809 140926 116667 246756 Proteasome degradation%WikiPathways_20260211%WP302%Rattus norvegicus Proteasome degradation 498560 29669 29630 94198 29672 287772 81827 81816 24968 307821 58854 81920 303353 25596 29677 29675 24967 29545 287670 365388 64701 289924 29674 100360846 29425 296651 361831 289990 117262 83499 29614 85492 25581 287984 292766 81827 Prostaglandin synthesis and regulation%WikiPathways_20260211%WP303%Rattus norvegicus Prostaglandin synthesis and regulation 24326 29527 50672 25527 81778 24683 79242 85247 25291 24886 306283 292661 25673 25116 24653 24693 25526 25380 498475 29680 79124 25637 25117 84023 25652 79125 25575 81752 24929 24323 Glucocorticoid metabolism%WikiPathways_20260211%WP305%Rattus norvegicus Glucocorticoid metabolism 25117 191574 25116 29680 25146 24298 Striated muscle contraction%WikiPathways_20260211%WP316%Rattus norvegicus Striated muscle contraction 29248 29388 81633 287876 100361457 171409 29437 29389 295929 29556 290561 500450 296369 81818 117557 363925 311029 171009 252942 29275 24583 24852 84015 24838 24837 296313 292879 63836 25566 291245 IL 3 signaling pathway%WikiPathways_20260211%WP319%Rattus norvegicus IL 3 signaling pathway 24495 246144 171081 170911 366508 293621 84492 84598 24514 116689 25622 81515 25155 25734 25150 313050 24918 25126 25125 24705 25271 25513 29741 24185 361597 83427 25023 85385 25577 56011 84477 81504 313845 361388 63881 287942 54245 64639 24888 24887 64547 24672 25614 360820 83805 89829 140694 305679 24703 170851 363875 366957 116554 116590 50689 25159 25636 29431 24680 81736 24778 50686 84027 65199 114509 84482 24471 81649 81647 361696 295347 64041 289014 366126 64465 367786 156767 25261 25651 171075 50658 140583 60450 81686 81687 TCA cycle%WikiPathways_20260211%WP347%Rattus norvegicus TCA cycle 360975 298942 289217 296849 298596 25104 24551 289950 157074 81829 362404 114597 26955 361071 29554 89813 24368 94173 81530 G1 to S cell cycle control%WikiPathways_20260211%WP348%Rattus norvegicus G1 to S cell cycle control 24708 684111 399489 311562 304573 83571 114483 25737 114851 65131 54237 24842 246060 116651 25729 310616 25164 314856 171150 29157 59102 100360427 298400 362291 25203 58919 84389 100362927 29728 406169 313479 29685 288532 312538 313138 54238 299112 266713 291927 291885 313978 291105 361178 287524 680111 308937 362165 25112 85242 295596 295052 362304 362485 Synthesis and degradation of ketone bodies%WikiPathways_20260211%WP349%Rattus norvegicus Synthesis and degradation of ketone bodies 79238 24450 690163 117099 Regulation of actin cytoskeleton%WikiPathways_20260211%WP351%Rattus norvegicus Regulation of actin cytoskeleton 89812 116590 24260 309419 296654 304580 29431 64303 65052 60662 25266 363460 497931 85384 117542 361598 305679 25443 60323 114559 303634 79433 81645 25229 289021 25444 24329 360891 303342 306400 313024 311450 170851 65172 29348 81663 58823 63851 81822 29741 29432 25114 170633 53949 170630 64465 81814 116720 25313 25414 288057 365396 116499 25513 29433 309081 25111 366624 60350 24629 360854 170911 25614 66017 29368 117273 24782 84489 361632 170583 170582 29369 116723 24605 54250 60664 54319 81762 287876 100361457 60464 298947 363509 363875 114486 365355 361568 24205 293623 25267 84488 365865 294568 292756 114120 313845 54245 24506 25118 24703 315707 50689 303073 360820 24505 25022 366508 296078 83709 29271 24559 170700 25317 29251 25439 79114 170632 29349 54268 IL 1 signaling pathway%WikiPathways_20260211%WP355%Rattus norvegicus IL 1 signaling pathway 24494 60582 25466 25663 24493 117022 300177 314870 361677 305549 313121 315139 116554 360640 309361 140934 113894 25522 25528 25622 362418 29153 29156 116590 24185 311245 25493 81525 170851 50689 309165 81736 25738 300177 MAPK signaling pathway%WikiPathways_20260211%WP358%Rattus norvegicus MAPK signaling pathway 311245 499497 501560 304786 295347 54245 24493 29414 303823 170668 313121 50658 81504 500526 29332 314436 24329 24675 171378 292763 100361818 25388 29477 29434 60350 309295 24225 140926 25272 24559 311622 81649 84351 25387 25402 293860 289014 25625 360640 24471 311743 81663 59086 116667 171492 63995 114513 301363 24629 308106 25112 171103 25663 170538 65179 170851 363875 246781 117022 308267 29591 116590 29644 691905 114486 59109 81647 287398 314322 24681 85384 81809 60587 140724 116457 24494 311786 29513 286993 114495 361679 25233 498183 79114 25717 24674 25313 313022 116596 310738 287942 64666 50689 116554 24680 25730 25266 25054 25385 24629 24667 25022 64465 84489 362045 25114 24516 313845 24518 361568 293621 24842 365355 81736 114120 691810 24592 361714 24185 313874 170668 25676 81737 310533 293508 25636 498003 170920 309361 309452 293694 309165 363855 100360982 293847 497961 303330 311406 297682 246097 24653 361400 365057 309168 304530 361715 302983 306204 362332 24963 24605 24703 691907 311341 296091 140726 140725 306243 140729 140728 25398 257648 24239 29716 54234 114493 682930 25399 50688 116600 58942 29658 114862 29717 312668 116499 25317 54250 170633 116499 60662 170700 29348 29349 25444 25443 170632 170630 84488 63851 66017 29369 29368 60464 170582 29432 29431 Acetylcholine synthesis%WikiPathways_20260211%WP360%Rattus norvegicus Acetylcholine synthesis 140544 29554 25373 83817 25511 Wnt myofibroblastic activation of hepatic stellate cells%WikiPathways_20260211%WP3649%Rattus norvegicus Wnt myofibroblastic activation of hepatic stellate cells 25664 303181 Acetate mediated promotion of metabolic syndrome%WikiPathways_20260211%WP3650%Rattus norvegicus Acetate mediated promotion of metabolic syndrome 25320 24506 Beta oxidation meta pathway%WikiPathways_20260211%WP372%Rattus norvegicus Beta oxidation meta pathway 170670 364975 24539 113965 24849 140547 25363 25757 311569 50682 25288 311849 25014 171155 361676 25062 114024 298942 94340 64304 25413 25330 113976 117243 24158 Wnt signaling pathway%WikiPathways_20260211%WP375%Rattus norvegicus Wnt signaling pathway 364754 54237 64462 24246 306862 361765 303251 310704 64566 24882 307641 50689 24205 50554 503000 24703 83721 84027 81679 117526 293897 287280 116590 84353 64053 293992 29495 117273 25387 50658 81717 307511 116549 79128 289229 313121 171140 116457 24672 293649 25422 161452 84402 64512 245903 24680 497961 303330 363875 78973 25023 307740 64558 114487 266608 25388 24185 25400 362356 29134 362342 29382 60328 79257 83824 29456 312781 58919 84426 310552 114850 24681 83826 24245 361374 116554 360564 303181 84382 140586 83502 25252 306782 364952 65137 81650 500430 113927 24516 303811 Renin angiotensin system%WikiPathways_20260211%WP376%Rattus norvegicus Renin angiotensin system 314322 24310 309295 25679 24516 29432 25262 296370 24590 116590 81678 81504 116667 64017 85420 25272 311450 50658 84351 25614 292756 50689 290257 25153 81641 81647 24514 309165 25125 24654 54242 296078 116554 171105 363875 302668 292661 50646 117041 24179 24182 25627 24703 25636 29433 24180 29513 85385 116554 287398 24715 29431 363855 314436 170911 GPCRs class B secretin like%WikiPathways_20260211%WP378%Rattus norvegicus GPCRs class B secretin like 64124 361383 24953 25024 316137 116506 25321 170641 58959 81779 64680 24875 65096 171447 25051 60432 24167 25029 Proximal tubule transporters%WikiPathways_20260211%WP3881%Rattus norvegicus Proximal tubule transporters 24784 59114 116501 311651 54231 291819 29242 791259 288360 64076 29509 83500 25548 84395 29502 58980 84484 65202 64846 24211 25650 64190 664630 25550 291840 307811 29726 116726 83509 84551 170566 685232 312488 117596 299159 297566 298103 289407 297797 29757 116455 689779 117252 296981 170667 291969 297932 436582 Thick ascending limb transporters%WikiPathways_20260211%WP3882%Rattus norvegicus Thick ascending limb transporters 24784 117955 25065 24211 79430 308069 25240 79430 54231 29242 25650 64119 84020 29719 79425 24783 Angiotensin II signaling acute in thick ascending limbs%WikiPathways_20260211%WP3887%Rattus norvegicus Angiotensin II signaling acute in thick ascending limbs 25679 25262 81678 24680 29337 81666 24182 24180 81638 298646 25388 140694 25738 24600 50663 24244 85431 85431 24681 81743 24600 81745 25153 25636 50557 25233 24185 29414 Fructose metabolism in proximal tubules%WikiPathways_20260211%WP3894%Rattus norvegicus Fructose metabolism in proximal tubules 24189 292804 361730 24788 24362 25634 287716 25741 24192 25659 24190 24849 25058 60416 25058 303205 65197 366441 337920 Lipid droplet metabolism%WikiPathways_20260211%WP3901%Rattus norvegicus Lipid droplet metabolism 298199 680423 25288 361722 311617 114024 361676 84497 252900 81782 25055 296130 294324 406165 170919 311821 306582 313977 362261 25062 Hexoses metabolism in proximal tubules%WikiPathways_20260211%WP3916%Rattus norvegicus Hexoses metabolism in proximal tubules 25351 24849 25552 65197 24644 292804 298942 24642 246311 289950 311254 498881 24383 24651 171087 29554 24189 54705 64522 25058 24191 24190 100359982 116551 296849 81530 89813 25104 24159 25741 60416 361730 24788 25659 24192 25634 287716 24959 24333 25438 24334 362282 24401 25721 81829 24551 24534 24533 303205 366441 24362 ID signaling pathway%WikiPathways_20260211%WP397%Rattus norvegicus ID signaling pathway 25261 25587 25585 291023 24708 81758 680111 337868 114494 25729 314436 304786 83499 29577 293992 81819 299766 29148 78968 312897 29373 54251 25589 25671 50554 59328 25389 313050 25718 24482 301965 81736 309165 25644 84349 310738 25313 679869 Inflammatory response pathway%WikiPathways_20260211%WP40%Rattus norvegicus Inflammatory response pathway 56822 156767 25712 29169 116562 25084 25746 313050 298941 103690850 140924 287287 171369 29393 192362 84352 84349 25625 25408 25704 117036 140433 445442 24497 114103 GPCRs other%WikiPathways_20260211%WP409%Rattus norvegicus GPCRs other 24326 57305 679957 117257 54258 362547 60590 29238 310444 260326 170641 445269 314213 25369 362436 60448 170704 24414 64443 25439 25449 81645 494319 81668 25321 293370 29413 25432 29595 405331 25248 29733 25706 294807 192649 498233 767613 65032 679975 287511 24938 25273 56821 60463 114098 24260 293374 25652 171447 366274 405137 294123 294121 117029 287480 83465 54305 310780 295144 Beta oxidation of unsaturated fatty acids%WikiPathways_20260211%WP418%Rattus norvegicus Beta oxidation of unsaturated fatty acids 170670 24158 29740 171155 117543 GPCRs class C metabotropic glutamate pheromone%WikiPathways_20260211%WP42%Rattus norvegicus GPCRs class C metabotropic glutamate pheromone 83633 24419 60590 293546 81657 312790 24414 24417 24415 500349 287805 24418 81672 24247 24416 Insulin induced PI3K Akt and MAPK in hepatocytes%WikiPathways_20260211%WP4229%Rattus norvegicus Insulin induced PI3K Akt and MAPK in hepatocytes 498416 29376 64226 64639 24159 116590 313845 84482 690987 85385 117045 292887 83840 50689 25623 60445 304298 303158 65052 24185 26954 50686 81771 287871 116636 24640 24703 24855 56718 29304 81504 24505 Ethanol metabolism resulting in production of ROS by CYP2E1%WikiPathways_20260211%WP4268%Rattus norvegicus Ethanol metabolism resulting in production of ROS by CYP2E1 116554 25086 64188 170851 83619 25023 Insulin signaling%WikiPathways_20260211%WP439%Rattus norvegicus Insulin signaling 81804 366508 65052 116693 360406 363875 84027 24714 303259 81504 114858 24778 361715 84351 301363 81749 117550 361512 81675 25233 171492 25532 170538 24185 64185 26954 25558 60352 25513 365057 29376 116720 29741 25272 303604 292763 50689 501560 50557 314436 85385 54245 246273 303443 317203 24954 289754 84482 116636 306117 25023 363855 361696 313845 366957 314322 298947 83521 171498 114203 29513 690987 24855 293692 116667 170920 85496 114495 100362311 25139 116596 25741 60445 314384 81803 25718 25522 25012 287398 58844 85420 81771 117269 81649 83840 309168 78975 64630 24697 287871 116554 65038 171136 313121 114095 80849 29517 689314 50658 25622 25623 24516 252971 117045 314612 83764 292699 65261 361388 299145 50686 84006 65248 686098 85384 303823 500036 24703 64310 56718 24680 25330 54268 293694 81745 293621 63881 294515 498416 24330 308463 24803 361632 116590 64665 170851 313022 171497 308106 500690 84392 503027 58960 360640 IL 5 signaling pathway%WikiPathways_20260211%WP44%Rattus norvegicus IL 5 signaling pathway 81647 25126 24887 309684 84027 25021 287942 294515 25513 25734 114203 29741 314612 83571 50646 114103 25155 25290 81736 85385 25023 364712 84598 116590 81504 25493 24653 252971 24516 24918 29402 170538 314436 293621 24497 298947 50689 25125 81771 63881 24514 84353 24185 288077 24703 25622 50686 29624 367901 313644 81649 116689 50658 24649 83841 81515 363875 Hypertrophy model%WikiPathways_20260211%WP442%Rattus norvegicus Hypertrophy model 360950 116636 25663 58853 24493 25712 117045 25389 25705 24518 83476 27064 365977 25433 29596 29148 TNF alpha NF kB signaling pathway%WikiPathways_20260211%WP457%Rattus norvegicus TNF alpha NF kB signaling pathway 305240 305751 292747 81525 83840 140934 64314 363984 361029 307449 361055 309295 25404 29476 116667 29677 29155 116596 289831 24185 81650 29753 303024 58934 84027 24835 362356 361925 306886 309165 303602 287772 310877 156767 303285 24672 116549 311786 362607 304005 25493 25573 287367 312937 293960 25576 682457 311245 308267 246240 307821 25069 266610 361765 81736 25625 291885 287707 293860 84577 313245 252961 360640 353256 361810 161477 64640 100362027 306007 25402 56010 363599 499374 361167 309452 361825 83427 171492 305451 305606 305584 309361 25233 313128 498206 56011 140657 303518 315713 362491 84351 361711 24471 266764 361388 297893 365388 29542 312641 83614 84020 303604 25636 54244 25581 680493 83805 25522 299602 288532 29355 304294 641452 353233 81774 25614 25586 246756 83581 680611 50659 307641 287670 289924 681193 64026 304893 83582 60328 116633 85245 117042 685607 64322 313867 25622 362247 29425 Glutathione metabolism%WikiPathways_20260211%WP469%Rattus norvegicus Glutathione metabolism 81641 116568 64317 24377 116686 25458 116568 116684 29326 57298 499688 24424 295362 25260 29487 57298 29566 29739 GPCRs class A rhodopsin like%WikiPathways_20260211%WP473%Rattus norvegicus GPCRs class A rhodopsin like 287481 310869 301086 317219 25601 116677 170926 60448 294187 25248 64020 685243 767613 117264 29234 25354 299588 64636 288181 252939 25555 83683 29597 500317 288995 54305 25432 81645 25593 29256 114211 292409 29335 116498 25637 84023 306307 25652 298394 57302 25083 25324 293375 29290 25264 64042 192223 312787 298944 24717 25439 25369 690158 405362 25033 60669 24175 25370 100911796 365228 83567 289180 58949 50577 24180 25111 291361 81752 294204 25342 295734 117549 64021 24173 117097 25477 25265 25689 293370 24925 314386 64354 24929 29358 65140 299242 310444 365523 117027 24938 24473 405140 60451 302373 29238 78964 297952 292661 498289 297795 246075 81644 689936 287511 308163 25449 445269 100909648 29462 54258 171108 266769 289239 292413 24613 85268 309212 302378 29316 29636 294138 295822 266607 140473 25706 25340 25645 29412 292794 405280 29235 29595 24260 260319 24326 287516 60463 305711 83518 282839 25195 689917 691774 24816 29413 408199 29310 498475 114099 171104 308408 24174 366274 24182 84007 25635 65275 25229 24448 29471 363682 84022 293364 405331 64107 65032 25461 64803 25187 688737 25153 25726 24316 679957 24889 50672 81509 294197 287480 25245 302954 66024 171044 25323 405138 60628 498434 117029 80840 287673 363993 282832 294203 53949 Apoptosis modulation by HSP70%WikiPathways_20260211%WP487%Rattus norvegicus Apoptosis modulation by HSP70 24472 116667 25385 25625 25402 25309 64625 81736 266610 58918 25272 83533 306886 64314 64026 83584 246097 Osteoclast%WikiPathways_20260211%WP489%Rattus norvegicus Osteoclast 116469 117516 24481 24782 297566 304695 288264 29302 29175 25353 Nucleotide GPCRs%WikiPathways_20260211%WP502%Rattus norvegicus Nucleotide GPCRs 691774 25369 29290 117264 29597 25265 302378 29316 Fatty acid biosynthesis%WikiPathways_20260211%WP504%Rattus norvegicus Fatty acid biosynthesis 25288 298381 50671 684538 116719 60581 114024 140547 246074 24159 29470 94340 113965 361465 117243 311569 25104 117543 170465 Burn wound healing%WikiPathways_20260211%WP5057%Rattus norvegicus Burn wound healing 64152 27064 25527 29316 81687 25556 246310 25155 24804 24842 117257 171103 24494 25402 29393 290905 64032 311332 29437 24335 316033 25266 24516 24482 25325 Biosynthesis of aldosterone and cortisol%WikiPathways_20260211%WP508%Rattus norvegicus Biosynthesis of aldosterone and cortisol 29632 25146 24294 24298 Catecholamine synthesis%WikiPathways_20260211%WP513%Rattus norvegicus Catecholamine synthesis 25699 24616 25085 24311 24661 Notch signaling pathway%WikiPathways_20260211%WP517%Rattus norvegicus Notch signaling pathway 303101 81751 362268 303811 500847 114125 29147 297893 29146 304591 29419 170905 360801 303251 54244 498089 303539 365872 56761 29492 83721 311332 292732 60433 289231 406162 25496 29382 315119 79225 29577 293774 29192 81717 G13 signaling pathway%WikiPathways_20260211%WP520%Rattus norvegicus G13 signaling pathway 29355 366624 308516 60323 308666 100360623 361598 366508 362456 306417 65172 83708 363875 303882 29433 116723 25272 682507 29741 25594 308106 83620 81762 307483 64465 83840 25537 mRNA processing%WikiPathways_20260211%WP529%Rattus norvegicus mRNA processing 298095 100361269 291295 687711 689116 313131 291794 299620 362229 294232 116655 29428 287643 362361 192246 680891 319110 366276 499958 500538 288701 290666 100359574 292019 295607 362223 308650 313056 117280 362829 84474 361811 687575 117259 117282 308472 116650 291078 362160 689890 311166 361035 362264 59087 293671 252855 361995 362630 362178 314417 79256 298916 83498 499390 299284 116697 60421 304277 304431 361814 305479 293505 362630 84599 299256 366952 494445 259229 291877 295270 683927 292007 56763 362612 65169 365842 287530 313583 287269 499420 84473 307540 29667 171552 29497 311670 308335 362687 304859 361126 313620 291534 100362099 361859 302855 171365 63996 361574 298075 287727 171305 310820 287739 362251 292729 140931 317385 289693 Complement and coagulation cascades%WikiPathways_20260211%WP547%Rattus norvegicus Complement and coagulation cascades 289055 79126 302470 64459 25584 25692 25619 64036 24617 294257 24231 81750 29687 54243 29333 289395 117512 54249 24237 304929 304917 83580 25087 24903 294257 24231 116669 362634 295703 50692 298566 155012 287527 290757 29436 64023 84007 25268 24233 25439 54243 29333 24153 313421 79224 25407 29251 113936 25048 24366 85253 24946 306761 312705 29243 192262 24548 260320 ACE inhibitor pathway%WikiPathways_20260211%WP557%Rattus norvegicus ACE inhibitor pathway 24310 24600 25087 24903 24179 81638 24182 24715 25245 IL 2 signaling pathway%WikiPathways_20260211%WP569%Rattus norvegicus IL 2 signaling pathway 116562 25126 25326 54245 304063 81515 24185 301965 25622 83427 252971 24918 366508 117045 498798 313050 25704 24703 24251 56718 288516 84598 81504 170851 25155 500526 25513 89829 290364 116554 84477 25125 309361 50646 24514 500538 29741 24413 24654 309165 170911 103690850 140924 311030 81736 25522 311021 25150 50658 289014 116590 83840 298947 287942 313845 81649 50689 294515 116689 85385 29376 Hedgehog signaling pathway%WikiPathways_20260211%WP574%Rattus norvegicus Hedgehog signaling pathway 366452 29499 54237 89830 25273 140588 313757 361769 290284 363067 140589 54244 25255 304729 25203 24483 291936 Cardiovascular signaling%WikiPathways_20260211%WP590%Rattus norvegicus Cardiovascular signaling 24185 25313 24472 24337 29393 29360 290905 116669 114559 83685 24471 29332 64314 296603 116640 360457 116466 365355 25267 25402 114495 29271 83584 85490 94203 292406 116554 306628 25654 114487 294568 Cholesterol metabolism%WikiPathways_20260211%WP632%Rattus norvegicus Cholesterol metabolism 29637 81782 25073 29580 25675 25728 81727 64191 78968 292697 81681 83791 100360417 24539 25292 81726 89784 140910 ATM signaling pathway%WikiPathways_20260211%WP654%Rattus norvegicus ATM signaling pathway 24708 680110 24842 24887 298795 25309 58919 25203 114483 114212 25729 58918 497672 399489 311562 114851 25402 54237 492821 25112 116502 p53 pathway%WikiPathways_20260211%WP655%Rattus norvegicus p53 pathway 116589 298795 24855 54237 301013 64394 24842 114212 680110 362931 83628 50557 114851 24484 492821 64625 25112 292949 24617 25309 25203 25405 24887 58918 304798 294518 287585 25163 246097 362675 25402 140941 140941 114483 140583 289508 25729 p53 signal pathway%WikiPathways_20260211%WP656%Rattus norvegicus p53 signal pathway 25402 24887 314856 300126 58918 64625 24482 24484 680110 24842 54237 25591 317389 492821 291005 317673 292949 246097 140941 25729 Steroid biosynthesis%WikiPathways_20260211%WP66%Rattus norvegicus Steroid biosynthesis 24470 24470 117182 360348 29632 79243 289055 25322 25146 29632 24470 79244 29540 G protein signaling pathways%WikiPathways_20260211%WP73%Rattus norvegicus G protein signaling pathways 24679 140929 64508 64532 114120 64199 116633 171378 114124 25521 24896 170538 60449 81666 50664 24627 25023 361568 309242 25740 54223 309962 24605 685451 680149 81667 25725 24674 25686 293508 50599 29322 361458 303634 312720 81529 81742 81636 24611 313834 302950 305509 293024 308776 83425 117273 79254 25643 498549 85420 298024 290646 245986 29340 24681 24400 24680 84006 79218 114117 293621 25522 60323 360540 29241 84420 25636 24626 81744 246150 81663 25262 24782 Integrin mediated cell adhesion%WikiPathways_20260211%WP74%Rattus norvegicus Integrin mediated cell adhesion 311144 116694 170922 25614 29302 83577 313845 114636 295347 25021 54245 171495 64350 29360 81762 296456 360606 305679 63881 685269 83685 366957 360820 296078 170851 25414 25724 362800 81745 29155 83805 309081 295378 114486 363425 308995 499271 25118 25150 25272 29161 24717 293621 114509 25404 311061 85385 24511 29154 29414 58960 29741 685004 306260 310683 24703 296603 64465 29156 309684 29432 303200 116590 686098 171337 114495 29433 170921 25233 29153 363875 25537 304546 361517 114517 29431 24185 81504 257645 364786 315744 114559 117558 292756 54268 60352 313494 114858 IL 9 signaling pathway%WikiPathways_20260211%WP8%Rattus norvegicus IL 9 signaling pathway 25126 29376 89829 25125 170851 84598 103690850 140924 50689 24185 25513 192218 24500 25622 116558 24918 81504 116643 85385 25326 116590 Hepatocyte growth factor receptor signaling%WikiPathways_20260211%WP94%Rattus norvegicus Hepatocyte growth factor receptor signaling 63881 24703 171337 83805 25614 54245 50646 360820 361388 50557 24446 58960 25676 292763 24553 170851 25118 314436 295347 116590 29431 116554 170911 287942 25125 293621 313845 24516 81504 24511 309081 25622 50689 314322}